Advanced Biological Information Reserch Division

Research Output 2001 2019

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2019

Loss of TET proteins in regulatory T cells promotes abnormal proliferation, Foxp3 destabilization and IL-17 expression

Nakatsukasa, H., Oda, M., Yin, J., Chikuma, S., Ito, M., Koga-Iizuka, M., Someya, K., Kitagawa, Y., Ohkura, N., Sakaguchi, S., Koya, I., Sanosaka, T., Kohyama, J., Tsukada, Y., Yamanaka, S., Takamura-Enya, T., Lu, Q. & Yoshimura, A., Jan 1 2019, In : International Immunology. 31, 5, p. 335-347 13 p.

Research output: Contribution to journalArticle

Interleukin-17
Protein Transport
Regulatory T-Lymphocytes
Immunoglobulin G
5-Methylcytosine
2017
10 Citations (Scopus)

Improvement of Foxp3 stability through CNS2 demethylation by TET enzyme induction and activation

Someya, K., Nakatsukasa, H., Ito, M., Kondo, T., Tateda, K. I., Akanuma, T., Koya, I., Sanosaka, T., Kohyama, J., Tsukada, Y., Takamura-Enya, T. & Yoshimura, A., Aug 1 2017, In : International Immunology. 29, 8, p. 365-375 11 p., dxx049.

Research output: Contribution to journalArticle

Enzyme Induction
Enzyme Activation
Catalytic Domain
5-Methylcytosine
Oxygen
2015
32 Citations (Scopus)

Histone chaperone CAF-1 mediates repressive histone modifications to protect preimplantation mouse embryos from endogenous retrotransposons

Hatanaka, Y., Inoue, K., Oikawa, M., Kamimura, S., Ogonuki, N., Kodama, E. N., Ohkawa, Y., Tsukada, Y. & Ogura, A., Nov 24 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 47, p. 14641-14646 6 p.

Research output: Contribution to journalArticle

Chromatin Assembly Factor-1
Histone Code
Histone Chaperones
Retroelements
Blastocyst
18 Citations (Scopus)

Maternal TET3 is dispensable for embryonic development but is required for neonatal growth

Tsukada, Y., Akiyama, T. & Nakayama, K., Oct 28 2015, In : Scientific reports. 5, 15876.

Research output: Contribution to journalArticle

5-Methylcytosine
Zygote
Embryonic Development
Mothers
DNA Methylation
2013
48 Citations (Scopus)

Identification of the KDM2/7 histone lysine demethylase subfamily inhibitor and its antiproliferative activity

Suzuki, T., Ozasa, H., Itoh, Y., Zhan, P., Sawada, H., Mino, K., Walport, L., Ohkubo, R., Kawamura, A., Yonezawa, M., Tsukada, Y., Tumber, A., Nakagawa, H., Hasegawa, M., Sasaki, R., Mizukami, T., Schofield, C. J. & Miyata, N., Sep 26 2013, In : Journal of Medicinal Chemistry. 56, 18, p. 7222-7231 10 p.

Research output: Contribution to journalArticle

Histone Demethylases
Enzyme Assays
Antineoplastic Agents
Histones
Lysine
37 Citations (Scopus)

The discovery of histone demethylases

Shi, Y. G. & Tsukada, Y., Sep 2013, In : Cold Spring Harbor perspectives in biology. 5, 9

Research output: Contribution to journalArticle

Histone Demethylases
Methylation
Histones
Lysergic Acid Diethylamide
Epigenomics
2010
6 Citations (Scopus)

In vitro histone demethylase assay

Tsukada, Y. & Nakayama, K., Oct 1 2010, In : Cold Spring Harbor Protocols. 5, 10

Research output: Contribution to journalArticle

Histone Demethylases
Assays
84 Citations (Scopus)

KDM7 is a dual demethylase for histone H3 Lys 9 and Lys 27 and functions in brain development

Tsukada, Y., Ishitani, T. & Nakayama, K., Mar 1 2010, In : Genes and Development. 24, 5, p. 432-437 6 p.

Research output: Contribution to journalArticle

Follistatin
Histones
Brain
Zebrafish
Methylation
2009
88 Citations (Scopus)

CHD8 suppresses p53-mediated apoptosis through histone H1 recruitment during early embryogenesis

Nishiyama, M., Oshikawa, K., Tsukada, Y., Nakagawa, T., Iemura, S. I., Natsume, T., Fan, Y., Kikuchi, A., Skoultchi, A. I. & Nakayama, K., Jan 19 2009, In : Nature Cell Biology. 11, 2, p. 172-182 11 p.

Research output: Contribution to journalArticle

Histones
Embryonic Development
Apoptosis
Transcriptional Activation
DNA Helicases
2001
79 Citations (Scopus)

High Intensity ERK Signal Mediates Hepatocyte Growth Factor-induced Proliferation Inhibition of the Human Hepatocellular Carcinoma Cell Line HepG2

Tsukada, Y., Miyazawa, K. & Kitamura, N., Nov 2 2001, In : Journal of Biological Chemistry. 276, 44, p. 40968-40976 9 p.

Research output: Contribution to journalArticle

Hepatocyte Growth Factor
Hepatocellular Carcinoma
Hep G2 Cells
Cells
Cell Line