Biology, Faculty of Science

Research Output 1981 2019

2019

Corrigendum to “Differential genomic destabilisation in human cells with pathogenic MSH2 mutations introduced by genome editing” [Exp. Cell Res. 377 (2019) 24–35](S0014482719300825)(10.1016/j.yexcr.2019.02.020)

Hayashida, G., Shioi, S., Hidaka, K., Fujikane, R., Hidaka, M., Tsurimoto, T., Tsuzuki, T., Oda, S. & Nakatsu, Y., Oct 1 2019, In : Experimental Cell Research. 383, 1, 111432.

Research output: Contribution to journalComment/debate

Flap Endonucleases
Escherichia coli
Methylnitrosourea
Mutation
Genomic Instability

Differential genomic destabilisation in human cells with pathogenic MSH2 mutations introduced by genome editing

Hayashida, G., Shioi, S., Hidaka, K., Fujikane, R., Hidaka, M., Tsurimoto, T., Tsuzuki, T., Oda, S. & Nakatsu, Y., Apr 15 2019, In : Experimental Cell Research. 377, 1-2, p. 24-35 12 p.

Research output: Contribution to journalArticle

Open Access
Microsatellite Instability
DNA Mismatch Repair
Mutation
Microsatellite Repeats
Hereditary Nonpolyposis Colorectal Neoplasms

Heterochromatin suppresses gross chromosomal rearrangements at centromeres by repressing Tfs1/TFIIS-dependent transcription

Okita, A. K., Zafar, F., Su, J., Weerasekara, D., Kajitani, T., Takahashi, T. S., Kimura, H., Murakami, Y., Masukata, H. & Nakagawa, T., 2019, In : Communications biology. 2, p. 17

Research output: Contribution to journalArticle

Heterochromatin
Centromere
RNA Polymerase II
Methylation
Mutation
1 Citation (Scopus)

Heterochromatin suppresses gross chromosomal rearrangements at centromeres by repressing Tfs1/TFIIS-dependent transcription

Okita, A. K., Zafar, F., Su, J., Weerasekara, D., Kajitani, T., Takahashi, T., Kimura, H., Murakami, Y., Masukata, H. & Nakagawa, T., Dec 1 2019, In : Communications Biology. 2, 1, 17.

Research output: Contribution to journalArticle

Open Access
Methylation
Heterochromatin
RNA Polymerase II
Centromere
centromeres

Specific basic patch-dependent multimerization of Saccharomyces cerevisiae ORC on single-stranded DNA promotes ATP hydrolysis

Kawakami, H., Muraoka, R., Ohashi, E., Kawabata, K., Kanamoto, S., Chichibu, T., Tsurimoto, T. & Katayama, T., Sep 1 2019, In : Genes to Cells. 24, 9, p. 608-618 11 p.

Research output: Contribution to journalArticle

Origin Recognition Complex
Single-Stranded DNA
Saccharomyces cerevisiae
Hydrolysis
Adenosine Triphosphate
2018

An albino mutant of the Japanese rat snake (Elaphe climacophora) carries a nonsense mutation in the tyrosinase gene

Iwanishi, S., Zaitsu, S., Shibata, H. & Nitasaka, E., Jan 1 2018, In : Genes and Genetic Systems. 93, 4, p. 163-167 5 p.

Research output: Contribution to journalArticle

Monophenol Monooxygenase
Snakes
Nonsense Codon
Pets
Genes
4 Citations (Scopus)

Anterograde and retrograde signaling by an Aplysia neurotrophin forms a transsynaptic functional unit

Jin, I., Udo, H., Kassabov, S., Kosmidis, S., Zhu, H., Kandel, E. R. & Hawkins, R. D., Nov 13 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 46, p. E10951-E10960

Research output: Contribution to journalArticle

Aplysia
Nerve Growth Factors
Synapses
Autocrine Communication
Neurons
1 Citation (Scopus)

Anthocyanin mutants of japanese and common morning glories exhibit normal proanthocyanidin accumulation in seed coats

Park, K. I., Nitasaka, E. & Hoshino, A., Jan 1 2018, In : Plant Biotechnology. 35, 3, p. 259-266 8 p.

Research output: Contribution to journalArticle

Ipomoea nil
Anthocyanins
proanthocyanidins
anthocyanins
Seeds
3 Citations (Scopus)

Autocrine signaling by an Aplysia neurotrophin forms a presynaptic positive feedback loop

Jin, I., Udo, H., Nicholls, R., Zhu, H., Kandel, E. R. & Hawkins, R. D., Nov 20 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 47, p. E11168-E11177

Research output: Contribution to journalArticle

Autocrine Communication
Aplysia
Nerve Growth Factors
Synapses
Neuronal Plasticity
3 Citations (Scopus)

Direct binding of Cdt2 to PCNA is important for targeting the CRL4Cdt2 E3 ligase activity to Cdt1

Hayashi, A., Giakoumakis, N. N., Heidebrecht, T., Ishii, T., Panagopoulos, A., Caillat, C., Takahara, M., Hibbert, R. G., Suenaga, N., Stadnik-Spiewak, M., Takahashi, T., Shiomi, Y., Taraviras, S., Von Castelmur, E., Lygerou, Z., Perrakis, A. & Nishitani, H., Jan 1 2018, In : Life Science Alliance. 1, 6, Y.

Research output: Contribution to journalArticle

proliferating cell nuclear antigen
Ubiquitin-Protein Ligases
Proliferating Cell Nuclear Antigen
antigen
ligases
2 Citations (Scopus)

Early-life Photoperiod Influences Depression-like Behavior, Prepulse Inhibition of the Acoustic Startle Response, and Hippocampal Astrogenesis in Mice

Takai, Y., Kawai, M., Ogo, T., Ichinose, T., Furuya, S., Takaki, N., Tone, Y., Udo, H., Furuse, M. & Yasuo, S., Mar 15 2018, In : Neuroscience. 374, p. 133-143 11 p.

Research output: Contribution to journalArticle

Startle Reflex
Photoperiod
Acoustics
Depression
Dentate Gyrus

Erratum: Regulation of mitotic recombination between DNA repeats in centromeres (Nucleic acids research (2017) 45 19 (11222-11235))

Zafar, F., Okita, A. K., Onaka, A. T., Su, J., Katahira, Y., Nakayama, J. I., Takahashi, T. S., Masukata, H. & Nakagawa, T., Feb 16 2018, In : Nucleic acids research. 46, 3, 1 p.

Research output: Contribution to journalComment/debate

Open Access
Centromere
Nucleic Acids
Genetic Recombination
DNA
Research
17 Citations (Scopus)

Herpes Simplex Virus 1 VP22 Inhibits AIM2-Dependent Inflammasome Activation to Enable Efficient Viral Replication

Maruzuru, Y., Ichinohe, T., Sato, R., Miyake, K., Okano, T., Suzuki, T., Koshiba, T., Koyanagi, N., Tsuda, S., Watanabe, M., Arii, J., Kato, A. & Kawaguchi, Y., Feb 14 2018, In : Cell Host and Microbe. 23, 2, p. 254-265.e7

Research output: Contribution to journalArticle

Inflammasomes
Human Herpesvirus 1
Interleukin-18
Interleukin-1
Cytokines
5 Citations (Scopus)

Insecticidal activity of the metalloprotease AprA occurs through suppression of host cellular and humoral immunity

Lee, S. A., Jang, S. H., Kim, B. H., Shibata, T., Yoo, J., Jung, Y., Kawabata, S-I. & Lee, B. L., Apr 1 2018, In : Developmental and Comparative Immunology. 81, p. 116-126 11 p.

Research output: Contribution to journalArticle

Metalloproteases
Humoral Immunity
Cellular Immunity
Insects
Innate Immunity
1 Citation (Scopus)
Enzyme Precursors
Serine Proteases
Lipopolysaccharides
Chemical activation
Molecules
1 Citation (Scopus)

Mice lacking hippocampal left-right asymmetry show non-spatial learning deficits

Shimbo, A., Kosaki, Y., Ito, I. & Watanabe, S., Jan 15 2018, In : Behavioural Brain Research. 336, p. 156-165 10 p.

Research output: Contribution to journalArticle

Knockout Mice
Learning
Pyramidal Cells
Task Performance and Analysis
Short-Term Memory

Novel Distinctive Roles of Docking Proteins in Short-term Synaptic Plasticity of Frog Neuromuscular Transmission Revealed by Botulinum Neurotoxins

Imafuku, Y., Enomoto, K. I., Kataoka, H., Ito, I. & Maeno, T., Jan 15 2018, In : Neuroscience. 369, p. 374-385 12 p.

Research output: Contribution to journalArticle

Neuronal Plasticity
Neurotoxins
Anura
Synaptosomal-Associated Protein 25
Proteins
4 Citations (Scopus)

Nucleosomes around a mismatched base pair are excluded via an Msh2-dependent reaction with the aid of SNF2 family ATPase Smarcad1

Terui, R., Nagao, K., Kawasoe, Y., Taki, K., Higashi, T. L., Tanaka, S., Nakagawa, T., Obuse, C., Masukata, H. & Takahashi, T. S., Jun 13 2018, In : Genes & development.

Research output: Contribution to journalArticle

DNA Mismatch Repair
Nucleosomes
Base Pairing
Adenosine Triphosphatases
Chromatin Assembly Factor-1
2 Citations (Scopus)

Pluripotency and a secretion mechanism of Drosophila transglutaminase

Shibata, T. & Kawabata, S-I., Mar 1 2018, In : Journal of biochemistry. 163, 3, p. 165-176 12 p.

Research output: Contribution to journalReview article

Transglutaminases
Drosophila
Glutamine
Exosomes
Acylation
5 Citations (Scopus)

Shelterin promotes tethering of late replication origins to telomeres for replication-timing control

Ogawa, S., Kido, S., Handa, T., Ogawa, H., Asakawa, H., Takahashi, T., Nakagawa, T., Hiraoka, Y. & Masukata, H., Aug 1 2018, In : EMBO Journal. 37, 15, e98997.

Research output: Contribution to journalArticle

Replication Origin
Telomere
Schizosaccharomyces
S Phase
Telomere-Binding Proteins
3 Citations (Scopus)

Two conserved amino acids within the NSs of severe fever with thrombocytopenia syndrome phlebovirus are essential for anti-interferon activity

Moriyama, M., Igarashi, M., Koshiba, T., Irie, T., Takada, A. & Ichinohe, T., Oct 1 2018, In : Journal of virology. 92, 19, e00706.

Research output: Contribution to journalArticle

Phlebovirus
thrombocytopenia
IKappaB kinase
interferons
Thrombocytopenia
2017
7 Citations (Scopus)

Drosophila TG-A transglutaminase is secreted via an unconventional Golgi-independent mechanism involving exosomes and two types of fatty acylations

Shibata, T., Hadano, J., Kawasaki, D., Dong, X., Kawabata, S-I. & Sllner, T., Jan 1 2017, In : Journal of Biological Chemistry. 292, 25, p. 10723-10734 12 p.

Research output: Contribution to journalArticle

Exosomes
Acylation
Transglutaminases
Drosophila
Lipoylation
3 Citations (Scopus)

Facultative parthenogenesis validated by DNA analyses in the green anaconda (Eunectes murinus)

Shibata, H., Sakata, S., Hirano, Y., Nitasaka, E. & Sakabe, A., Dec 2017, In : PloS one. 12, 12, e0189654.

Research output: Contribution to journalArticle

Parthenogenesis
Boidae
parthenogenesis
Clutches
Microsatellite Repeats
3 Citations (Scopus)

Functions of multiple clamp and clamp-loader complexes in eukaryotic DNA replication

Ohashi, E. & Tsurimoto, T., Jan 1 2017, Advances in Experimental Medicine and Biology. Springer New York LLC, p. 135-162 28 p. (Advances in Experimental Medicine and Biology; vol. 1042).

Research output: Chapter in Book/Report/Conference proceedingChapter

Replication Protein C
Loaders
Clamping devices
Proliferating Cell Nuclear Antigen
DNA Replication
2 Citations (Scopus)

Genetic engineering approach to develop next-generation reagents for endotoxin quantification

Mizumura, H., Ogura, N., Aketagawa, J., Aizawa, M., Kobayashi, Y., Kawabata, S. I. & Oda, T., Jan 1 2017, In : Innate Immunity. 23, 2, p. 136-146 11 p.

Research output: Contribution to journalArticle

Genetic Engineering
Endotoxins
Horseshoe Crabs
Insects
Peptide Hydrolases
6 Citations (Scopus)

Human CTF18-RFC clamp-loader complexed with non-synthesising DNA polymerase ϵ efficiently loads the PCNA sliding clamp

Fujisawa, R., Ohashi, E., Hirota, K. & Tsurimoto, T., Jan 1 2017, In : Nucleic acids research. 45, 8, p. 4550-4563 14 p.

Research output: Contribution to journalArticle

Proliferating Cell Nuclear Antigen
DNA-Directed DNA Polymerase
DNA
Proteins
1 Citation (Scopus)

PirB regulates asymmetries in hippocampal circuitry

Ukai, H., Kawahara, A., Hirayama, K., Case, M. J., Aino, S., Miyabe, M., Wakita, K., Oogi, R., Kasayuki, M., Kawashima, S., Sugimoto, S., Chikamatsu, K., Nitta, N., Koga, T., Shigemoto, R., Takai, T. & Ito, I., Jun 1 2017, In : PloS one. 12, 6, e0179377.

Research output: Contribution to journalArticle

Major Histocompatibility Complex
immunoglobulins
Immunoglobulins
major histocompatibility complex
receptors

PirB regulates asymmetries in hippocampal circuitry

Ukai, H., Kawahara, A., Hirayama, K., Case, M. J., Aino, S., Miyabe, M., Wakita, K., Oogi, R., Kasayuki, M., Kawashima, S., Sugimoto, S., Chikamatsu, K., Nitta, N., Koga, T., Shigemoto, R., Takai, T. & Ito, I., Jun 8 2017, In : PLoS One. 12, 6, p. e0179377

Research output: Contribution to journalArticle

Major Histocompatibility Complex
immunoglobulins
Immunoglobulins
major histocompatibility complex
receptors
5 Citations (Scopus)

Regulation of mitotic recombination between DNA repeats in centromeres

Zafar, F., Okita, A. K., Onaka, A. T., Su, J., Katahira, Y., Nakayama, J. I., Takahashi, T., Masukata, H. & Nakagawa, T., Jan 1 2017, In : Nucleic acids research. 45, 19, p. 11222-11235 14 p.

Research output: Contribution to journalArticle

Centromere
Genetic Recombination
DNA
Homologous Recombination
Chromosome Segregation
6 Citations (Scopus)

RLR-mediated antiviral innate immunity requires oxidative phosphorylation activity

Koshiba, T., Jul 14 2017, In : Scientific Reports. 7, 5379, 5379.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Sensing and Processing of DNA Interstrand Crosslinks by the Mismatch Repair Pathway

Kato, N., Kawasoe, Y., Williams, H., Coates, E., Roy, U., Shi, Y., Beese, L. S., Schärer, O. D., Yan, H., Gottesman, M. E., Takahashi, T. S. & Gautier, J., Oct 31 2017, In : Cell Reports. 21, 5, p. 1375-1385 11 p.

Research output: Contribution to journalArticle

DNA Mismatch Repair
DNA Replication
Repair
DNA
Processing
2 Citations (Scopus)
Takifugu
Saxitoxin
Tetraodontiformes
Tetrodotoxin
Denaturation
3 Citations (Scopus)

The asymmetry defect of hippocampal circuitry impairs working memory in β2-microglobulin deficient mice

Goto, K. & Ito, I., Mar 1 2017, In : Neurobiology of Learning and Memory. 139, p. 50-55 6 p.

Research output: Contribution to journalArticle

Short-Term Memory
Brain
N-Methyl-D-Aspartate Receptors
Major Histocompatibility Complex
Hippocampus
6 Citations (Scopus)

The dominant role of proofreading exonuclease activity of replicative polymerase ε in cellular tolerance to cytarabine (Ara-C)

Tsuda, M., Terada, K., Ooka, M., Kobayashi, K., Sasanuma, H., Fujisawa, R., Tsurimoto, T., Yamamoto, J., Iwai, S., Kadoda, K., Akagawa, R., Huang, S. Y. N., Pommier, Y., Sale, J. E., Takeda, S. & Hirota, K., Jan 1 2017, In : Oncotarget. 8, 20, p. 33457-33474 18 p.

Research output: Contribution to journalArticle

Exonucleases
Cytarabine
Trifluridine
Fluorouracil
DNA-Directed DNA Polymerase
3 Citations (Scopus)
Transglutaminases
Polyamines
Masks
Transcription Factors
DNA
2016
10 Citations (Scopus)

Claspin recruits Cdc7 kinase for initiation of DNA replication in human cells

Yang, C. C., Suzuki, M., Yamakawa, S., Uno, S., Ishii, A., Yamazaki, S., Fukatsu, R., Fujisawa, R., Sakimura, K., Tsurimoto, T. & Masai, H., Jul 12 2016, In : Nature communications. 7, 12135.

Research output: Contribution to journalArticle

phosphorylation
Phosphorylation
knockout mice
DNA Replication
Phosphotransferases
8 Citations (Scopus)

Conserved interaction of Ctf18-RFC with DNA polymerase ε is critical for maintenance of genome stability in Saccharomyces cerevisiae

Okimoto, H., Tanaka, S., Araki, H., Ohashi, E. & Tsurimoto, T., May 1 2016, In : Genes to Cells. 21, 5, p. 482-491 10 p.

Research output: Contribution to journalArticle

Saccharomycetales
Genomic Instability
Proliferating Cell Nuclear Antigen
DNA-Directed DNA Polymerase
Saccharomyces cerevisiae
40 Citations (Scopus)

Genome sequence and analysis of the Japanese morning glory Ipomoea nil

Hoshino, A., Jayakumar, V., Nitasaka, E., Toyoda, A., Noguchi, H., Itoh, T., Shin, T., Minakuchi, Y., Koda, Y., Nagano, A. J., Yasugi, M., Honjo, M. N., Kudoh, H., Seki, M., Kamiya, A., Shiraki, T., Carninci, P., Asamizu, E., Nishide, H., Tanaka, S. & 14 others, Park, K. I., Morita, Y., Yokoyama, K., Uchiyama, I., Tanaka, Y., Tabata, S., Shinozaki, K., Hayashizaki, Y., Kohara, Y., Suzuki, Y., Sugano, S., Fujiyama, A., Iida, S. & Sakakibara, Y., Nov 8 2016, In : Nature communications. 7, 13295.

Research output: Contribution to journalArticle

Ipomoea nil
morning
genome
Sequence Analysis
Convolvulaceae

Interaction between Viral Proteins and Mitochondria

Yoshizumi, T., Yasukawa, K. & Koshiba, T., Aug 1 2016, In : Fukuoka igaku zasshi = Hukuoka acta medica. 107, 8, p. 148-154 7 p.

Research output: Contribution to journalReview article

Viral Proteins
Mitochondria
Antiviral Agents
Signal Transduction
RNA Viruses
20 Citations (Scopus)

In vivo evidence for translesion synthesis by the replicative DNA polymerase δ

Hirota, K., Tsuda, M., Mohiuddin, Tsurimoto, T., Cohen, I. S., Livneh, Z., Kobayashi, K., Narita, T., Nishihara, K., Murai, J., Iwai, S., Guilbaud, G., Sale, J. E. & Takeda, S., Sep 6 2016, In : Nucleic acids research. 44, 15, p. 7242-7250 9 p.

Research output: Contribution to journalArticle

DNA-Directed DNA Polymerase
Holoenzymes
Mutagenesis
Base Pairing
Molecular Biology
14 Citations (Scopus)

MutSα maintains the mismatch repair capability by inhibiting PCNA unloading

Kawasoe, Y., Tsurimoto, T., Nakagawa, T., Masukata, H. & Takahashi, T., Jul 12 2016, In : eLife. 5, 2016JULY, e15155.

Research output: Contribution to journalArticle

DNA Mismatch Repair
Proliferating Cell Nuclear Antigen
Unloading
Repair
DNA
19 Citations (Scopus)

PCNA Retention on DNA into G2/M Phase Causes Genome Instability in Cells Lacking Elg1

Johnson, C., Gali, V. K., Takahashi, T. & Kubota, T., Jul 19 2016, In : Cell Reports. 16, 3, p. 684-695 12 p.

Research output: Contribution to journalArticle

Genomic Instability
G2 Phase
Proliferating Cell Nuclear Antigen
Cell Division
Genes
7 Citations (Scopus)

Rad51 and Rad54 promote noncrossover recombination between centromere repeats on the same chromatid to prevent isochromosome formation

Onaka, A. T., Toyofuku, N., Inoue, T., Okita, A. K., Sagawa, M., Su, J., Shitanda, T., Matsuyama, R., Zafar, F., Takahashi, T. S., Masukata, H. & Nakagawa, T., Jan 1 2016, In : Nucleic acids research. 44, 22, p. 10744-10757 14 p.

Research output: Contribution to journalArticle

Isochromosomes
Chromatids
Centromere
Genetic Recombination
Homologous Recombination
1 Citation (Scopus)
Origin Recognition Complex
Saccharomyces cerevisiae
Yeasts
Genetic Phenomena
Saccharomycetales
4 Citations (Scopus)

RNA interference directed against the Transglutaminase gene triggers dysbiosis of gut microbiota in Drosophila

Sekihara, S., Shibata, T., Hyakkendani, M. & Kawabata, S-I., Nov 25 2016, In : Journal of Biological Chemistry. 291, 48, p. 25077-25087 11 p.

Research output: Contribution to journalArticle

Dysbiosis
Transglutaminases
Acetobacter
RNA Interference
Diptera
31 Citations (Scopus)

The RNA- and TRIM25-binding domains of influenza virus NS1 protein are essential for suppression of NLRP3 inflammasomemediated interleukin-1β secretion

Moriyama, M., Chen, I. Y., Kawaguchi, A., Koshiba, T., Nagata, K., Takeyama, H., Hasegawa, H. & Ichinohe, T., Apr 1 2016, In : Journal of virology. 90, 8, p. 4105-4114 10 p.

Research output: Contribution to journalArticle

interleukin-1
Orthomyxoviridae
Interleukin-1
secretion
RNA
5 Citations (Scopus)

Transglutaminase in Invertebrates

Shibata, T. & Kawabata, S-I., Jan 1 2016, Transglutaminases: Multiple Functional Modifiers and Targets for New Drug Discovery. Springer Japan, p. 117-127 11 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Transglutaminases
Invertebrates
Horseshoe Crabs
Antigen-antibody reactions
Genetic Techniques
2015
2 Citations (Scopus)
Vaccinia
Vaccinium
Cloning
Genetic Recombination
Organism Cloning
14 Citations (Scopus)

Crosslinking of a Peritrophic Matrix Protein Protects Gut Epithelia from Bacterial Exotoxins

Shibata, T., Maki, K., Hadano, J., Fujikawa, T., Kitazaki, K., Koshiba, T. & Kawabata, S. I., Jan 1 2015, In : PLoS pathogens. 11, 10, e1005244.

Research output: Contribution to journalArticle

Exotoxins
Transglutaminases
Epithelium
Diptera
Proteins
3 Citations (Scopus)

Factor B is the second lipopolysaccharide-binding protease zymogen in the horseshoe crab coagulation cascade

Kobayashi, Y., Takahashi, T., Shibata, T., Ikeda, S., Koshiba, T., Mizumura, H., Oda, T. & Kawabata, S-I., Jul 31 2015, In : Journal of Biological Chemistry. 290, 31, p. 19379-19386 8 p.

Research output: Contribution to journalArticle

Horseshoe Crabs
Enzyme Precursors
Complement Factor B
Coagulation
Lipopolysaccharides