Research Output 1984 2020

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2020

Vascularized cancer on a chip: The effect of perfusion on growth and drug delivery of tumor spheroid

Nashimoto, Y., Okada, R., Hanada, S., Arima, Y., Nishiyama, K., Miura, T. & Yokokawa, R., Jan 2020, In : Biomaterials. 229, 119547.

Research output: Contribution to journalArticle

Drug delivery
Tumors
Perfusion
Growth
Pharmaceutical Preparations
2019

Claudins and JAM-A coordinately regulate tight junction formation and epithelial polarity

Otani, T., Nguyen, T. P., Tokuda, S., Sugihara, K., Sugawara, T., Furuse, K., Miura, T., Ebnet, K. & Furuse, M., Oct 7 2019, In : The Journal of cell biology. 218, 10, p. 3372-3396 25 p.

Research output: Contribution to journalArticle

Open Access
Claudins
Tight Junctions
Tight Junction Proteins
Permeability
Membranes
2 Citations (Scopus)

Fhod1, an actin-organizing formin family protein, is dispensable for cardiac development and function in mice

Sanematsu, F., Kanai, A., Ushijima, T., Shiraishi, A., Abe, T., Kage, Y., Sumimoto, H. & Takeya, R., Feb 1 2019, In : Cytoskeleton. 76, 2, p. 219-229 11 p.

Research output: Contribution to journalArticle

Actins
Proteins
Staining and Labeling
Lac Operon
Aptitude
1 Citation (Scopus)

JunB plays a crucial role in development of regulatory T cells by promoting IL-2 signaling

Katagiri, T., Yamazaki, S., Fukui, Y., Aoki, K., Yagita, H., Nishina, T., Mikami, T., Katagiri, S., Shiraishi, A., Kimura, S., Tateda, K., Sumimoto, H., Endo, S., Kameda, H. & Nakano, H., Sep 1 2019, In : Mucosal Immunology. 12, 5, p. 1104-1117 14 p.

Research output: Contribution to journalArticle

Open Access
Regulatory T-Lymphocytes
Interleukin-2
T-Lymphocytes
Dextran Sulfate
Colitis

Mark1 regulates distal airspace expansion through type I pneumocyte flattening in lung development

Fumoto, K., Takigawa-Imamura, H., Sumiyama, K., Yoshimura, S. H., Maehara, N. & Kikuchi, A., Dec 13 2019, In : Journal of cell science. 132, 24

Research output: Contribution to journalArticle

Open Access
Alveolar Epithelial Cells
Organoids
Microtubules
Phosphotransferases
Fibroblasts
2018
5 Citations (Scopus)

Combining Turing and 3D vertex models reproduces autonomous multicellular morphogenesis with undulation, tubulation, and branching

Okuda, S., Miura, T., Inoue, Y., Adachi, T. & Eiraku, M., Dec 1 2018, In : Scientific reports. 8, 1, 2386.

Research output: Contribution to journalArticle

morphogenesis
inhibitor
apoptosis
vesicle
hysteresis
2 Citations (Scopus)

Differential cell surface recruitment of the superoxide-producing NADPH oxidases Nox1, Nox2 and Nox5: The role of the small GTPase Sar1

Kiyohara, T., Miyano, K., Kamakura, S., Hayase, J., Chishiki, K., Kohda, A. & Sumimoto, H., Jun 2018, In : Genes to Cells. 23, 6, p. 480-493 14 p.

Research output: Contribution to journalArticle

Monomeric GTP-Binding Proteins
NADPH Oxidase
Qa-SNARE Proteins
Superoxides
Endoplasmic Reticulum
4 Citations (Scopus)

Elasticity-based boosting of neuroepithelial nucleokinesis via indirect energy transfer from mother to daughter

Shinoda, T., Nagasaka, A., Inoue, Y., Higuchi, R., Minami, Y., Kato, K., Suzuki, M., Kondo, T., Kawaue, T., Saito, K., Ueno, N., Fukazawa, Y., Nagayama, M., Miura, T., Adachi, T. & Miyata, T., Apr 20 2018, In : PLoS Biology. 16, 4, e2004426.

Research output: Contribution to journalArticle

Energy Transfer
Elasticity
Carisoprodol
energy transfer
elasticity (mechanics)

Engineering a Perfusable Vascular Network in a Microfluidic Device for a Morphological Analysis

Nashimoto, Y., Teraoka, Y., Arima, Y., Hanada, S., Nakamasu, A., Kotera, H., Nishiyama, K., Miura, T. & Yokokawa, R., Jan 1 2018, In : IEEJ Transactions on Sensors and Micromachines. 138, 7, p. 275-280 6 p.

Research output: Contribution to journalArticle

Microfluidics
Tissue culture
Nutrients
Tissue
Oxygen
4 Citations (Scopus)

Interaction between cardiac myosin-binding protein C and formin Fhod3

Matsuyama, S., Kage, Y., Fujimoto, N., Ushijima, T., Tsuruda, T., Kitamura, K., Shiose, A., Asada, Y., Sumimoto, H. & Takeya, R., May 8 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 19, p. E4386-E4395

Research output: Contribution to journalArticle

Cardiac Myosins
Sarcomeres
Familial Hypertrophic Cardiomyopathy
Phenotype
Hypertrophic Cardiomyopathy
13 Citations (Scopus)

MUTE Directly Orchestrates Cell-State Switch and the Single Symmetric Division to Create Stomata

Han, S. K., Qi, X., Sugihara, K., Dang, J. H., Endo, T. A., Miller, K. L., Kim, E. D., Miura, T. & Torii, K. U., May 7 2018, In : Developmental Cell. 45, 3, p. 303-315.e5

Research output: Contribution to journalArticle

cdc Genes
Cells
Switches
Gene expression
Gene Expression
2 Citations (Scopus)

Perfusable vascular network with a tissue model in a microfluidic device

Nashimoto, Y., Teraoka, Y., Banan Sadeghian, R., Nakamasu, A., Arima, Y., Hanada, S., Kotera, H., Nishiyama, K., Miura, T. & Yokokawa, R., Apr 4 2018, In : Journal of Visualized Experiments. 2018, 134, e57242.

Research output: Contribution to journalArticle

Lab-On-A-Chip Devices
Microfluidics
Blood Vessels
Tissue
Angiogenesis Inducing Agents
8 Citations (Scopus)

The actin-organizing formin protein Fhod3 is required for postnatal development and functional maintenance of the adult heart in mice

Ushijima, T., Fujimoto, N., Matsuyama, S., Kan-O, M., Kiyonari, H., Shioi, G., Kage, Y., Yamasaki, S., Takeya, R. & Sumimoto, H., Jan 1 2018, In : Journal of Biological Chemistry. 293, 1, p. 148-162 15 p.

Research output: Contribution to journalArticle

Sarcomeres
Actins
Maintenance
Cardiomegaly
Proteins
2017
8 Citations (Scopus)

Exogenous cellulase switches cell interdigitation to cell elongation in an RIC1-dependent manner in Arabidopsis thaliana cotyledon pavement cells

Higaki, T., Takigawa-Imamura, H., Akita, K., Kutsuna, N., Kobayashi, R., Hasezawa, S. & Miura, T., Jan 1 2017, In : Plant and Cell Physiology. 58, 1, p. 106-119 14 p.

Research output: Contribution to journalArticle

Cellulase
Cotyledon
Arabidopsis
endo-1,4-beta-glucanase
cotyledons
29 Citations (Scopus)

Integrating perfusable vascular networks with a three-dimensional tissue in a microfluidic device

Nashimoto, Y., Hayashi, T., Kunita, I., Nakamasu, A., Torisawa, Y. S., Nakayama, M., Takigawa-Imamura, H., Kotera, H., Nishiyama, K., Miura, T. & Yokokawa, R., Jun 2017, In : Integrative Biology (United Kingdom). 9, 6, p. 506-518 13 p.

Research output: Contribution to journalArticle

Lab-On-A-Chip Devices
Microfluidics
Blood Vessels
Tissue
Microchannels
8 Citations (Scopus)

Late postnatal shifts of parvalbumin and nitric oxide synthase expression within the GABAergic and glutamatergic phenotypes of inferior colliculus neurons

Fujimoto, H., Konno, K., Watanabe, M. & Jinno, S., Mar 1 2017, In : Journal of Comparative Neurology. 525, 4, p. 868-884 17 p.

Research output: Contribution to journalArticle

Inferior Colliculi
Parvalbumins
Glutamate Decarboxylase
Nitric Oxide Synthase
Phenotype

Mathematical modeling for meshwork formation of endothelial cells in fibrin gels

Sasaki, D., Nakajima, H., Yamaguchi, Y., Yokokawa, R., Ei, S. I. & Miura, T., Sep 21 2017, In : Journal of Theoretical Biology. 429, p. 95-104 10 p.

Research output: Contribution to journalArticle

Endothelial Cells
fibrin
Endothelial cells
Fibrin
Mathematical Modeling
8 Citations (Scopus)

Modulation of apical constriction by Wnt signaling is required for lung epithelial shape transition

Fumoto, K., Takigawa-Imamura, H., Sumiyama, K., Kaneiwa, T. & Kikuchi, A., Jan 1 2017, In : Development (Cambridge). 144, 1, p. 151-162 12 p.

Research output: Contribution to journalArticle

Air Sacs
Constriction
Lung
Cell Shape
Epithelium
13 Citations (Scopus)

Reelin transiently promotes N-cadherin-dependent neuronal adhesion during mouse cortical development

Matsunaga, Y., Noda, M., Murakawa, H., Hayashi, K., Nagasaka, A., Inoue, S., Miyata, T., Miura, T., Kubo, K. I. & Nakajima, K., Feb 21 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 8, p. 2048-2053 6 p.

Research output: Contribution to journalArticle

Cadherins
Neurons
Ependymoglial Cells
Adhesiveness
Neocortex
2 Citations (Scopus)
Cell Polarity
Tight Junctions
Epithelial Cells
Spindle Apparatus
Proteins
Gi-Go GTP-Binding Protein alpha Subunits
Pertussis Toxin
Adenosine Diphosphate
Stabilization
G-Protein-Coupled Receptors
11 Citations (Scopus)

The AP-1 transcription factor JunB is required for Th17 cell differentiation

Yamazaki, S., Tanaka, Y., Araki, H., Kohda, A., Sanematsu, F., Arasaki, T., Duan, X., Miura, F., Katagiri, T., Shindo, R., Nakano, H., Ito, T., Fukui, Y., Endo, S. & Sumimoto, H., Dec 1 2017, In : Scientific reports. 7, 1, 17402.

Research output: Contribution to journalArticle

Th17 Cells
Transcription Factor AP-1
Cell Differentiation
Helper-Inducer T-Lymphocytes
Autoimmune Experimental Encephalomyelitis
8 Citations (Scopus)

TRPC3-Nox2 complex mediates doxorubicin-induced myocardial atrophy

Shimauchi, T., Numaga-Tomita, T., Ito, T., Nishimura, A., Matsukane, R., Oda, S., Hoka, S., Ide, T., Koitabashi, N., Uchida, K., Sumimoto, H., Mori, Y. & Nishida, M., Aug 3 2017, In : JCI Insight. 2, 15

Research output: Contribution to journalArticle

Open Access
NADPH Oxidase
Doxorubicin
Atrophy
Cardiac Myocytes
Compliance
2016
3 Citations (Scopus)

A new mathematical model for pattern formation by cranial sutures

Yoshimura, K., Kobayashi, R., Ohmura, T., Kajimoto, Y. & Miura, T., Nov 7 2016, In : Journal of Theoretical Biology. 408, p. 66-74 9 p.

Research output: Contribution to journalArticle

Cranial Sutures
sutures
Pattern Formation
Bone
Skull
10 Citations (Scopus)

A Theoretical Model of Jigsaw-Puzzle Pattern Formation by Plant Leaf Epidermal Cells

Higaki, T., Kutsuna, N., Akita, K., Takigawa-Imamura, H., Yoshimura, K. & Miura, T., Apr 2016, In : PLoS Computational Biology. 12, 4, e1004833.

Research output: Contribution to journalArticle

Plant Leaves
Cell Wall
Pattern Formation
Theoretical Model
Theoretical Models
1 Citation (Scopus)

C-rel regulates inscuteable gene expression during mouse embryonic stem cell differentiation

Ishibashi, R., Kozuki, S., Kamakura, S., Sumimoto, H. & Toyoshima, F., Feb 12 2016, In : Journal of Biological Chemistry. 291, 7, p. 3333-3345 13 p.

Research output: Contribution to journalArticle

Stem cells
Gene expression
Cell Differentiation
Gene Expression
Proto-Oncogene Proteins c-rel
13 Citations (Scopus)

Notch-mediated lateral inhibition regulates proneural wave propagation when combined with EGF-mediated reaction diffusion

Sato, M., Yasugi, T., Minami, Y., Miura, T. & Nagayama, M., Aug 30 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 35, p. E5153-E5162

Research output: Contribution to journalArticle

Epidermal Growth Factor
Salts
Computer Simulation
Drosophila
97 Citations (Scopus)

Protein-retention expansion microscopy of cells and tissues labeled using standard fluorescent proteins and antibodies

Tillberg, P. W., Chen, F., Piatkevich, K. D., Zhao, Y., Yu, C. C., English, B. P., Gao, L., Martorell, A., Suk, H. J., Yoshida, F., Degennaro, E. M., Roossien, D. H., Gong, G., Seneviratne, U., Tannenbaum, S. R., Desimone, R., Cai, D. & Boyden, E. S., Sep 1 2016, In : Nature Biotechnology. 34, 9, p. 987-992 6 p.

Research output: Contribution to journalArticle

Antibodies
Microscopy
Microscopic examination
Tissue
Proteins
12 Citations (Scopus)

Quantitative evaluation of the natural progression of keratoconus using three-dimensional optical coherence tomography

Fujimoto, H., Maeda, N., Shintani, A., Nakagawa, T., Fuchihata, M., Higashiura, R. & Nishida, K., Jul 2016, In : Investigative Ophthalmology and Visual Science. 57, 9, p. OCT169-OCT175

Research output: Contribution to journalArticle

Keratoconus
Optical Coherence Tomography
Edema
Tomography
Nonlinear Dynamics
3 Citations (Scopus)

Rat Articular Cartilages Change Their Tissue and Protein Compositions During Perinatal Period

Kobayashi-Miura, M., Miura, T., Osago, H., Yamaguchi, Y., Aoyama, T., Tanabe, T., Matsumoto, K. I. & Fujita, Y., Feb 1 2016, In : Journal of Veterinary Medicine Series C: Anatomia Histologia Embryologia. 45, 1, p. 9-18 10 p.

Research output: Contribution to journalArticle

perinatal period
protein composition
Articular Cartilage
cartilage
rats
12 Citations (Scopus)

Regional Differences in Tear Film Stability and Meibomian Glands in Patients with Aqueous-Deficient Dry Eye

Koh, S., Ikeda, C., Fujimoto, H., Oie, Y., Soma, T., Maeda, N. & Nishida, K., Jul 1 2016, In : Eye and Contact Lens. 42, 4, p. 250-255 6 p.

Research output: Contribution to journalArticle

Meibomian Glands
Tears
Eyelids
Nose
5 Citations (Scopus)
Ankyrin Repeat
Terminal Repeat Sequences
Nuclear Proteins
Transcriptional Activation
Chemical activation
3 Citations (Scopus)

Transgenic expression of the formin protein fhod3 selectively in the embryonic heart: Role of actin-binding activity of fhod3 and its sarcomeric localization during myofibrillogenesis

Fujimoto, N., Kan-O, M., Ushijima, T., Kage, Y., Tominaga, R., Sumimoto, H. & Takeya, R., Feb 1 2016, In : PloS one. 11, 2, e0148472.

Research output: Contribution to journalArticle

Muscle Development
muscle development
actin
Actins
heart
19 Citations (Scopus)

TRPC3-GEF-H1 axis mediates pressure overload-induced cardiac fibrosis

Numaga-Tomita, T., Kitajima, N., Kuroda, T., Nishimura, A., Miyano, K., Yasuda, S., Kuwahara, K., Sato, Y., Ide, T., Birnbaumer, L., Sumimoto, H., Mori, Y. & Nishida, M., Dec 19 2016, In : Scientific reports. 6, 39383.

Research output: Contribution to journalArticle

Cardiac Myocytes
Fibrosis
Microtubules
Pressure
Fibroblasts
33 Citations (Scopus)

TRPC3 positively regulates reactive oxygen species driving maladaptive cardiac remodeling

Kitajima, N., Numaga-Tomita, T., Watanabe, M., Kuroda, T., Nishimura, A., Miyano, K., Yasuda, S., Kuwahara, K., Sato, Y., Ide, T., Birnbaumer, L., Sumimoto, H., Mori, Y. & Nishida, M., Nov 11 2016, In : Scientific reports. 6, 37001.

Research output: Contribution to journalArticle

NADPH Oxidase
Reactive Oxygen Species
Physiological Adaptation
Proteasome Endopeptidase Complex
Cardiac Myocytes
2015

Air Pressure-Induced Iridocornea Contact in a Patient With Primary Angle Closure Observed With a Dynamic Scheimpflug Analyzer

Kawashima, R., Matsushita, K., Fujimoto, H., Maeda, N. & Nishida, K., Jun 19 2015, In : Journal of Glaucoma. 24, 5, p. e137-e138

Research output: Contribution to journalArticle

Air Pressure
Corneal Endothelium
Iris
Intraocular Pressure
Mechanical Stress
9 Citations (Scopus)

A wireless neural recording system with a precision motorized microdrive for freely behaving animals

Hasegawa, T., Fujimoto, H., Tashiro, K., Nonomura, M., Tsuchiya, A. & Watanabe, D., 2015, In : Scientific reports. 5, 7853.

Research output: Contribution to journalArticle

Brain
Electrodes
Neurons
Animal Behavior
Social Behavior
8 Citations (Scopus)
Lipocalins
Gene encoding
Glucocorticoids
Lipopolysaccharides
Glycoproteins
10 Citations (Scopus)

Models of lung branching morphogenesis

Miura, T., Mar 1 2015, In : Journal of biochemistry. 157, 3, p. 121-127 7 p.

Research output: Contribution to journalArticle

Morphogenesis
Mathematical models
Lung
Theoretical Models
Developmental Biology
20 Citations (Scopus)

Relationship between corneal guttae and quality of vision in patients with mild fuchs' endothelial corneal dystrophy

Watanabe, S., Oie, Y., Fujimoto, H., Soma, T., Koh, S., Tsujikawa, M., Maeda, N. & Nishida, K., Oct 1 2015, In : Ophthalmology. 122, 10, p. 2103-2109 7 p.

Research output: Contribution to journalArticle

Fuchs' Endothelial Dystrophy
Contrast Sensitivity
Visual Acuity
Cataract
Corneal Edema
4 Citations (Scopus)
Scaffolds
proteins
Crystal structure
Proteins
crystal structure
4 Citations (Scopus)
Acetyltransferases
Tubulin
Stabilization
Substrates
Coenzyme A
4 Citations (Scopus)

Time-dependent localization of high- and low-sulfated keratan sulfates in the song nuclei of developing zebra finches

Fujimoto, H., Ohgomori, T., Abe, K., Uchimura, K., Kadomatsu, K. & Jinno, S., Nov 2015, In : European Journal of Neuroscience. 42, 9, p. 2716-2725 10 p.

Research output: Contribution to journalArticle

Keratan Sulfate
Finches
Equidae
Music
Proteoglycans
12 Citations (Scopus)

Tooth germ invagination from cell-cell interaction: Working hypothesis on mechanical instability

Takigawa-Imamura, H., Morita, R., Iwaki, T., Tsuji, T. & Yoshikawa, K., Oct 7 2015, In : Journal of Theoretical Biology. 382, p. 284-291 8 p.

Research output: Contribution to journalArticle

Tooth Germ
Germ Cells
Cell Communication
teeth
Cell
2014
23 Citations (Scopus)

Arachidonic acid induces direct interaction of the p67phox-Rac complex with the phagocyte oxidase Nox2, leading to superoxide production

Matono, R., Miyano, K., Kiyohara, T. & Sumimoto, H., Jan 1 2014, In : Journal of Biological Chemistry. 289, 36, p. 24874-24884 11 p.

Research output: Contribution to journalArticle

Phagocytes
Arachidonic Acid
Superoxides
Oxidoreductases
Guanosine Triphosphate
15 Citations (Scopus)

Corneal biomechanical properties in 3 corneal transplantation techniques with a dynamic Scheimpflug analyzer

Maeda, N., Ueki, R., Fuchihata, M., Fujimoto, H., Koh, S. & Nishida, K., Jan 1 2014, In : Japanese Journal of Ophthalmology. 58, 6, p. 483-489 7 p.

Research output: Contribution to journalArticle

Corneal Transplantation
Descemet Stripping Endothelial Keratoplasty
Penetrating Keratoplasty
Cornea
Intraocular Pressure
9 Citations (Scopus)

DNA element downstream of the κB site in the Lcn2 promoter is required for transcriptional activation by IκBζ and NF-κB p50

Kohda, A., Yamazaki, S. & Sumimoto, H., Aug 2014, In : Genes to Cells. 19, 8, p. 620-628 9 p.

Research output: Contribution to journalArticle

Transcriptional Activation
Binding Sites
DNA
Nuclear Proteins
Genes
26 Citations (Scopus)

DOCK2 and DOCK5 act additively in neutrophils to regulate chemotaxis, superoxide production, and extracellular trap formation

Watanabe, M., Terasawa, M., Miyano, K., Yanagihara, T., Uruno, T., Sanematsu, F., Nishikimi, A., Côté, J. F., Sumimoto, H. & Fukui, Y., Dec 1 2014, In : Journal of Immunology. 193, 11, p. 5660-5667 8 p.

Research output: Contribution to journalArticle

Chemotaxis
Superoxides
Neutrophils
Reactive Oxygen Species
Guanine Nucleotide Exchange Factors
7 Citations (Scopus)

N-linked glycosylation of the superoxide-producing NADPH oxidase Nox1

Miyano, K. & Sumimoto, H., Jan 17 2014, In : Biochemical and Biophysical Research Communications. 443, 3, p. 1060-1065 6 p.

Research output: Contribution to journalArticle

Glycosylation
NADPH Oxidase
Superoxides
Polysaccharides
Substitution reactions
18 Citations (Scopus)

Quantitative regional differences in corneal endothelial abnormalities in the central and peripheral zones in Fuchs' endothelial corneal dystrophy

Fujimoto, H., Maeda, N., Soma, T., Oie, Y., Koh, S., Tsujikawa, M. & Nishida, K., Jul 24 2014, In : Investigative Ophthalmology and Visual Science. 55, 8, p. 5090-5098 9 p.

Research output: Contribution to journalArticle

Fuchs' Endothelial Dystrophy
Corneal Endothelium
Cornea
Endothelium