Center for Cellular and Molecular Medicine

Research Output

2020

Pathophysiology of chronic lymphocytic leukemia and human B1 cell development

Kikushige, Y., May 1 2020, In : International journal of hematology. 111, 5, p. 634-641 8 p.

Research output: Contribution to journalReview article

2019

Anti-GPRC5D/CD3 bispecific T-cell-redirecting antibody for the treatment of multiple myeloma

Kodama, T., Kochi, Y., Nakai, W., Mizuno, H., Baba, T., Habu, K., Sawada, N., Tsunoda, H., Shima, T., Miyawaki, K., Kikushige, Y., Mori, Y., Miyamoto, T., Maeda, T. & Akashi, K., Jan 1 2019, In : Molecular Cancer Therapeutics. 18, 9, p. 1555-1564 10 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Cell-based screen identifies a new potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth

Oshima, T., Niwa, Y., Kuwata, K., Srivastava, A., Hyoda, T., Tsuchiya, Y., Kumagai, M., Tsuyuguchi, M., Tamaru, T., Sugiyama, A., Ono, N., Zolboot, N., Aikawa, Y., Oishi, S., Nonami, A., Arai, F., Hagihara, S., Yamaguchi, J., Tama, F., Kunisaki, Y. & 6 others, Yagita, K., Ikeda, M., Kinoshita, T., Kay, S. A., Itami, K. & Hirota, T., Jan 23 2019, In : Science Advances. 5, 1, eaau9060.

Research output: Contribution to journalArticle

Open Access
17 Citations (Scopus)

Dedifferentiation process driven by TGF-beta signaling enhances stem cell properties in human colorectal cancer

Nakano, M., Kikushige, Y., Miyawaki, K., Kunisaki, Y., Mizuno, S., Takenaka, K., Tamura, S., Okumura, Y., Ito, M., Ariyama, H., Kusaba, H., Nakamura, M., Maeda, T., Baba, E. & Akashi, K., Feb 7 2019, In : Oncogene. 38, 6, p. 780-793 14 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

DrugThatGene: Integrative analysis to streamline the identification of druggable genes, pathways and protein complexes from CRISPR screens

Canver, M. C., Bauer, D. E., Maeda, T. & Pinello, L., Jan 1 2019, In : Bioinformatics. 35, 11, p. 1981-1984 4 p., bty913.

Research output: Contribution to journalArticle

Molecular pathogenesis of disease progression in MLL-rearranged AML

Kotani, S., Yoda, A., Kon, A., Kataoka, K., Ochi, Y., Shiozawa, Y., Hirsch, C., Takeda, J., Ueno, H., Yoshizato, T., Yoshida, K., Nakagawa, M. M., Nannya, Y., Kakiuchi, N., Yamauchi, T., Aoki, K., Shiraishi, Y., Miyano, S., Maeda, T., Maciejewski, J. P. & 3 others, Takaori-Kondo, A., Ogawa, S. & Makishima, H., Mar 1 2019, In : Leukemia. 33, 3, p. 612-624 13 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Pericytes in bone marrow

Kunisaki, Y., Jan 1 2019, Advances in Experimental Medicine and Biology. Springer New York LLC, p. 101-114 14 p. (Advances in Experimental Medicine and Biology; vol. 1122).

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Previous exposure to bortezomib is linked to a lower risk of engraftment syndrome after autologous hematopoietic stem cell transplantation

Mori, Y., Yoshimoto, G., Yuda, J. I., Hayashi, M., Odawara, J., Kuriyama, T., Sugio, T., Miyawaki, K., Kamezaki, K., Kato, K., Takenaka, K., Iwasaki, H., Maeda, T., Miyamoto, T. & Akashi, K., Jan 2 2019, In : Leukemia and Lymphoma. 60, 1, p. 271-273 3 p.

Research output: Contribution to journalLetter

1 Citation (Scopus)

Rational targeting of a NuRD subcomplex guided by comprehensive in situ mutagenesis

Sher, F., Hossain, M., Seruggia, D., Schoonenberg, V. A. C., Yao, Q., Cifani, P., Dassama, L. M. K., Cole, M. A., Ren, C., Vinjamur, D. S., Macias-Trevino, C., Luk, K., McGuckin, C., Schupp, P. G., Canver, M. C., Kurita, R., Nakamura, Y., Fujiwara, Y., Wolfe, S. A., Pinello, L. & 4 others, Maeda, T., Kentsis, A., Orkin, S. H. & Bauer, D. E., Jul 1 2019, In : Nature genetics. 51, 7, p. 1149-1159 11 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Regnase-1-mediated post-transcriptional regulation is essential for hematopoietic stem and progenitor cell homeostasis

Kidoya, H., Muramatsu, F., Shimamura, T., Jia, W., Satoh, T., Hayashi, Y., Naito, H., Kunisaki, Y., Arai, F., Seki, M., Suzuki, Y., Osawa, T., Akira, S. & Takakura, N., Dec 1 2019, In : Nature communications. 10, 1, 1072.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Successful rescue transplantation with desensitization procedure after primary graft failure due to donor-specific antibody

Minami, M., Matsushima, T., Mori, Y., Ishihara, D., Jinnnouchi, F., Takenaka, K., Henzan, T., Yoshimoto, G., Numata, A., Kato, K., Maeda, T., Miyamoto, T. & Akashi, K., Aug 1 2019, In : Bone Marrow Transplantation. 54, 8, p. 1374-1376 3 p.

Research output: Contribution to journalLetter

2018

CRISPRO: Identification of functional protein coding sequences based on genome editing dense mutagenesis Jin-Soo Kim

Schoonenberg, V. A. C., Cole, M. A., Yao, Q., MacIas-Treviño, C., Sher, F., Schupp, P. G., Canver, M. C., Maeda, T., Pinello, L. & Bauer, D. E., Oct 19 2018, In : Genome biology. 19, 1, 169.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Expression of PD-1 and PD-L1 on cytotoxic T lymphocytes and immune deficiency in a patient with adult T cell leukemia/lymphoma

Yanagihara, T., Ikematsu, Y., Kato, K., Yonekawa, A., Ideishi, S., Tochigi, T., Sugio, T., Miyawaki, K., Tanaka, K., Harada, E., Hamada, N. & Nakanishi, Y., Feb 1 2018, In : Annals of Hematology. 97, 2, p. 359-360 2 p.

Research output: Contribution to journalLetter

1 Citation (Scopus)

Gastrointestinal Graft-versus-Host Disease Is a Risk Factor for Postengraftment Bloodstream Infection in Allogeneic Hematopoietic Stem Cell Transplant Recipients

Mori, Y., Yoshimoto, G., Nishida, R., Sugio, T., Miyawaki, K., Shima, T., Nagasaki, Y., Miyake, N., Harada, Y., Kunisaki, Y., Kamezaki, K., Numata, A., Kato, K., Shiratsuchi, M., Maeda, T., Takenaka, K., Iwasaki, H., Shimono, N., Akashi, K. & Miyamoto, T., Nov 2018, In : Biology of Blood and Marrow Transplantation. 24, 11, p. 2302-2309 8 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS

Yamauchi, T., Masuda, T., Canver, M. C., Seiler, M., Semba, Y., Shboul, M., Al-Raqad, M., Maeda, M., Schoonenberg, V. A. C., Cole, M. A., Macias-Trevino, C., Ishikawa, Y., Yao, Q., Nakano, M., Arai, F., Orkin, S. H., Reversade, B., Buonamici, S., Pinello, L., Akashi, K. & 2 others, Bauer, D. E. & Maeda, T., Mar 12 2018, In : Cancer Cell. 33, 3, p. 386-400.e5

Research output: Contribution to journalArticle

23 Citations (Scopus)

Hepatitis C virus infection is an independent prognostic factor in follicular lymphoma

Shimono, J., Miyoshi, H., Kato, T., Sugio, T., Miyawaki, K., Kamimura, T., Miyagishima, T., Eto, T., Imaizumi, Y., Kato, K., Nagafuji, K., Akashi, K., Seto, M., Teshima, T. & Ohshima, K., Jan 1 2018, In : Oncotarget. 9, 2, p. 1717-1725 9 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2 Citations (Scopus)

Microenvironmental immune cell signatures dictate clinical outcomes for PTCL-NOS

Sugio, T., Miyawaki, K., Kato, K., Sasaki, K., Yamada, K., Iqbal, J., Miyamoto, T., Ohshima, K., Maeda, T., Miyoshi, H. & Akashi, K., Sep 11 2018, In : Blood Advances. 2, 17, p. 2242-2252 11 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Successful treatment of Ph ALL with hematopoietic stem cell transplantation from the same HLA-haploidentical related donor of previous liver transplantation

Sasaki, K., Mori, Y., Yoshimoto, G., Sakoda, T., Kato, K., Inadomi, K., Kamezaki, K., Takenaka, K., Iwasaki, H., Maeda, T., Miyamoto, T. & Akashi, K., Aug 3 2018, In : Leukemia and Lymphoma. 59, 8, p. 2005-2007 3 p.

Research output: Contribution to journalEditorial

1 Citation (Scopus)
2017

Comparison between antiemetic effects of palonosetron and granisetron on chemotherapy-induced nausea and vomiting in Japanese patients treated with R-CHOP

Uchida, M., Mori, Y., Nakamura, T., Kato, K., Kamezaki, K., Takenaka, K., Shiratsuchi, M., Kadoyama, K., Miyamoto, T. & Akashi, K., Jan 1 2017, In : Biological and Pharmaceutical Bulletin. 40, 9, p. 1499-1505 7 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Composite lymphoma of peripheral T-cell lymphoma and Hodgkin lymphoma, mixed cellularity type; pathological and molecular analysis

Ichikawa, A., Miyoshi, H., Yamauchi, T., Arakawa, F., Kawano, R., Muta, H., Sugita, Y., Akashi, K. & Ohshima, K., Apr 1 2017, In : Pathology International. 67, 4, p. 194-201 8 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Donor Lymphocyte Infusion for Relapsed Hematological Malignancies after Unrelated Allogeneic Bone Marrow Transplantation Facilitated by the Japan Marrow Donor Program

Medical Committee of Japan Marrow Donor Program, Japanese Data Center for Hematopoietic Cell Transplantation, Jun 2017, In : Biology of Blood and Marrow Transplantation. 23, 6, p. 938-944 7 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)
8 Citations (Scopus)

Erythropoietin signaling regulates heme biosynthesis

Chung, J., Wittig, J. G., Ghamari, A., Maeda, M., Dailey, T. A., Bergonia, H., Kafina, M. D., Coughlin, E. E., Minogue, C. E., Hebert, A. S., Li, L., Kaplan, J., Lodish, H. F., Bauer, D. E., Orkin, S. H., Cantor, A. B., Maeda, T., Phillips, J. D., Coon, J. J., Pagliarini, D. J. & 2 others, Dailey, H. A. & Paw, B. H., May 29 2017, In : eLife. 6, e24767.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Identification of unipotent megakaryocyte progenitors in human hematopoiesis

Miyawaki, K., Iwasaki, H., Jiromaru, T., Kusumoto, H., Yurino, A., Sugio, T., Uehara, Y., Odawara, J., Daitoku, S., Kunisaki, Y., Mori, Y., Arinobu, Y., Tsuzuki, H., Kikushige, Y., Iino, T., Kato, K., Takenaka, K., Miyamoto, T., Maeda, T. & Akashi, K., Jun 22 2017, In : Blood. 129, 25, p. 3332-3343 12 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Mobilization of human immature hematopoietic progenitors through combinatory use of bortezomib and immunomodulatory drugs

Tochigi, T., Aoki, T., Kikushige, Y., Kamimura, T., Ito, Y., Shima, T., Yamauchi, T., Mori, Y., Yoshimoto, G., Kamezaki, K., Kato, K., Takenaka, K., Iwasaki, H., Akashi, K. & Miyamoto, T., Apr 1 2017, In : International journal of hematology. 105, 4, p. 423-432 10 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Most T790M mutations are present on the same EGFR allele as activating mutations in patients with non–small cell lung cancer

Hidaka, N., Iwama, E., Kubo, N., Harada, T., Miyawaki, K., Tanaka, K., Okamoto, I., Baba, E., Akashi, K., Sasaki, H. & Nakanishi, Y., Jun 1 2017, In : Lung Cancer. 108, p. 75-82 8 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Recurrent subcutaneous sweet’s disease in a myelofibrosis patient treated with ruxolitinib before allogeneic stem cell transplantation

Sakoda, T., Kanamitsu, Y., Mori, Y., Sasaki, K., Yonemitsu, E., Nagae, K., Yoshimoto, G., Kamezaki, K., Kato, K., Takenaka, K., Miyamoto, T., Furue, M., Iwasaki, H. & Akashi, K., Jan 1 2017, In : Internal Medicine. 56, 18, p. 2481-2485 5 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

The simultaneous inhibition of the mTOR and MAPK pathways with Gnetin-C induces apoptosis in acute myeloid leukemia

Espinoza, J. L., Elbadry, M. I., Taniwaki, M., Harada, K., Trung, L. Q., Nakagawa, N., Takami, A., Ishiyama, K., Yamauchi, T., Takenaka, K. & Nakao, S., Aug 1 2017, In : Cancer Letters. 400, p. 127-136 10 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
2016

Allogeneic unrelated bone marrow transplantation from older donors results in worse prognosis in recipients with aplastic anemia

Japan Society for Hematopoietic Cell Transplantation, Apr 30 2016, In : Haematologica. 101, 5, p. 644-652 9 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Ascites retention during mogamulizumab treatment in a patient with adult T-cell leukemia/lymphoma

Shima, T., Kamezaki, K., Higashioka, K., Takashima, S., Yoshimoto, G., Kato, K., Muta, T., Takenaka, K., Iwasaki, H., Miyamoto, T. & Akashi, K., Jan 1 2016, In : Internal Medicine. 55, 13, p. 1793-1796 4 p.

Research output: Contribution to journalArticle

Calreticulin mutation does not contribute to disease progression in essential thrombocythemia by inhibiting phagocytosis

Daitoku, S., Takenaka, K., Yamauchi, T., Yurino, A., Jinnouchi, F., Nunomura, T., Eto, T., Kamimura, T., Higuchi, M., Harada, N., Saito, N., Miyamoto, T., Iwasaki, H. & Akashi, K., Sep 1 2016, In : Experimental Hematology. 44, 9, p. 817-825.e3

Research output: Contribution to journalArticle

7 Citations (Scopus)

Cord blood transplantation following reduced-intensity conditioning for adult-onset inherited hemophagocytic lymphohistiocytosis

Kuriyama, T., Kato, K., Sakamoto, K., Hayashi, M., Takashima, S., Mori, Y., Takenaka, K., Iwasaki, H., Teshima, T., Harada, N., Nagafuji, K., Miyamoto, T. & Akashi, K., Mar 15 2016, In : Internal Medicine. 55, 6, p. 667-671 5 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Enhanced Reconstitution of Human Erythropoiesis and Thrombopoiesis in an Immunodeficient Mouse Model with KitWv Mutations

Yurino, A., Takenaka, K., Yamauchi, T., Nunomura, T., Uehara, Y., Jinnouchi, F., Miyawaki, K., Kikushige, Y., Kato, K., Miyamoto, T., Iwasaki, H., Kunisaki, Y. & Akashi, K., Sep 13 2016, In : Stem Cell Reports. 7, 3, p. 425-438 14 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Mogamulizumab Treatment Prior to Allogeneic Hematopoietic Stem Cell Transplantation Induces Severe Acute Graft-versus-Host Disease

Sugio, T., Kato, K., Aoki, T., Ohta, T., Saito, N., Yoshida, S., Kawano, I., Henzan, H., Kadowaki, M., Takase, K., Muta, T., Miyawaki, K., Yamauchi, T., Shima, T., Takashima, S., Mori, Y., Yoshimoto, G., Kamezaki, K., Takenaka, K., Iwasaki, H. & 6 others, Ogawa, R., Ohno, Y., Eto, T., Kamimura, T., Miyamoto, T. & Akashi, K., Sep 1 2016, In : Biology of Blood and Marrow Transplantation. 22, 9, p. 1608-1614 7 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Myeloproliferative neoplasms: updates on molecular pathophysiology, diagnosis and treatment strategies

Takenaka, K., Jan 1 2016, In : [Rinsho ketsueki] The Japanese journal of clinical hematology. 57, 10, p. 1944-1955 12 p.

Research output: Contribution to journalArticle

Splenic irradiation provides transient palliation for symptomatic splenomegaly associated with primary myelofibrosis: a report on 14 patients

Kitanaka, A., Takenaka, K., Shide, K., Miyamoto, T., Kondo, T., Ozawa, K., Kurokawa, M., Akashi, K. & Shimoda, K., Apr 1 2016, In : International journal of hematology. 103, 4, p. 423-428 6 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2015

A multinational, open-label, phase 2 study of ruxolitinib in Asian patients with myelofibrosis: Japanese subset analysis

Oritani, K., Okamoto, S., Tauchi, T., Saito, S., Ohishi, K., Handa, H., Takenaka, K., Gopalakrishna, P., Amagasaki, T., Ito, K. & Akashi, K., Mar 6 2015, In : International journal of hematology. 101, 3, p. 295-304 10 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

A TIM-3/Gal-9 Autocrine Stimulatory Loop Drives Self-Renewal of Human Myeloid Leukemia Stem Cells and Leukemic Progression

Kikushige, Y., Miyamoto, T., Yuda, J., Jabbarzadeh-Tabrizi, S., Shima, T., Takayanagi, S. I., Niiro, H., Yurino, A., Miyawaki, K., Takenaka, K., Iwasaki, H. & Akashi, K., Sep 3 2015, In : Cell stem cell. 17, 3, p. 341-352 12 p., 1815.

Research output: Contribution to journalArticle

59 Citations (Scopus)

CD41 marks the initial myelo-erythroid lineage specification in adult mouse hematopoiesis: Redefinition of murine common myeloid progenitor

Miyawaki, K., Arinobu, Y., Iwasaki, H., Kohno, K., Tsuzuki, H., Iino, T., Shima, T., Kikushige, Y., Takenaka, K., Miyamoto, T. & Akashi, K., Mar 1 2015, In : STEM CELLS. 33, 3, p. 976-987 12 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Cytomegalovirus Reactivation after Allogeneic Hematopoietic Stem Cell Transplantation is Associated with a Reduced Risk of Relapse in Patients with Acute Myeloid Leukemia Who Survived to Day 100 after Transplantation: The Japan Society for Hematopoietic Cell Transplantation Transplantation-related Complication Working Group

Takenaka, K., Nishida, T., Asano-Mori, Y., Oshima, K., Ohashi, K., Mori, T., Kanamori, H., Miyamura, K., Kato, C., Kobayashi, N., Uchida, N., Nakamae, H., Ichinohe, T., Morishima, Y., Suzuki, R., Yamaguchi, T. & Fukuda, T., Nov 2015, In : Biology of Blood and Marrow Transplantation. 21, 11, p. 2008-2016 9 p.

Research output: Contribution to journalArticle

61 Citations (Scopus)
1 Citation (Scopus)

Efficacy and safety of ruxolitinib in Asian patients with myelofibrosis

Jung, C. W., Shih, L. Y., Xiao, Z., Jie, J., Hou, H. A., Du, X., Wang, M. C., Park, S., Eom, K. S., Oritani, K., Okamoto, S., Tauchi, T., Kim, J. S., Zhou, D., Saito, S., Li, J., Handa, H., Jianyong, L., Ohishi, K., Hou, M. & 8 others, Depei, W., Takenaka, K., Liu, T., Hu, Y., Amagasaki, T., Ito, K., Gopalakrishna, P. & Akashi, K., Jul 1 2015, In : Leukemia and Lymphoma. 56, 7, p. 2067-2074 8 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

M2 macrophages enhance pathological neovascularization in the mouse model of oxygen-induced retinopathy

Zhou, Y., Yoshida, S., Nakao, S., Yoshimura, T., Kobayashi, Y., Nakama, T., Kubo, Y., Miyawaki, K., Yamaguchi, M., Ishikawa, K., Oshima, Y., Akashi, K. & Ishibashi, T., Jan 1 2015, In : Investigative Ophthalmology and Visual Science. 56, 8, p. 4767-4777 11 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Preserved in vivo reconstitution ability of PBSCs cryopreserved for a decade at -80 °c

Shima, T., Iwasaki, H., Yamauchi, T., Kadowaki, M., Kiyosuke, M., Mochimaru, T., Takenaka, K., Miyamoto, T., Akashi, K. & Teshima, T., Sep 4 2015, In : Bone Marrow Transplantation. 50, 9, p. 1195-1200 6 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Successful Secondary Umbilical Cord Blood Transplantation for Graft Failure in Acute Myelogenous Leukemia, Treated with Modified One-Day Conditioning Regimen, and Graft-Versus-Host Disease Prophylaxis Consisting of Mycophenolate and Tacrolimus

Kawano, N., Kuriyama, T., Yoshida, S., Shimizu, I., Kobayashi, H., Takenaka, K., Uchida, N., Takami, A., Yamashita, K., Ueda, A. & Kikuchi, I., Jan 1 2015, In : Journal of clinical and experimental hematopathology : JCEH. 55, 2, p. 89-96 8 p.

Research output: Contribution to journalArticle

Successful treatment of adult Langerhans cell histiocytosis with intensified chemotherapy

Minami, M., Shima, T., Kato, K., Yamamoto, H., Tsuchihashi, K., Oku, S., Shimokawa, T., Tochigi, T., Yoshimoto, G., Kamezaki, K., Takenaka, K., Iwasaki, H., Oda, Y., Miyamoto, T. & Akashi, K., Aug 11 2015, In : International journal of hematology. 102, 2, p. 244-248 5 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2014

[Clinical aspects of primary myelofibrosis in Japan].

Shimoda, K., Takenaka, K., Kitanaka, A. & Akashi, K., 2014, In : [Rinshō ketsueki] The Japanese journal of clinical hematology. 55, 3, p. 289-294 6 p.

Research output: Contribution to journalReview article

[New approaches to target leukemia stem cells]

Takenaka, K. & Akashi, K., Jun 1 2014, In : Nihon rinsho. Japanese journal of clinical medicine. 72, 6, p. 1018-1025 8 p.

Research output: Contribution to journalArticle