Center for Cellular and Molecular Medicine

Research Output

[Effect of bortezomib-based induction therapy on the peripheral blood stem cell harvest in multiple myeloma].

Muta, T., Miyamoto, T., Fujisaki, T., Ohno, Y., Kamimura, T., Henzan, T., Kato, K., Takenaka, K., Iwasaki, H., Eto, T., Takamatsu, Y., Teshima, T., Akashi, K. & Fukuoka Blood, B., Jan 1 2013, In : [Rinshō ketsueki] The Japanese journal of clinical hematology. 54, 1, p. 109-116 8 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

[Leukemia stem cells: current understanding and future directions].

Takenaka, K. & Akashi, K., Apr 2012, In : Nihon rinsho. Japanese journal of clinical medicine. 70 Suppl 2, p. 139-145 7 p.

Research output: Contribution to journalArticle

[New approaches to target leukemia stem cells]

Takenaka, K. & Akashi, K., Jun 1 2014, In : Nihon rinsho. Japanese journal of clinical medicine. 72, 6, p. 1018-1025 8 p.

Research output: Contribution to journalArticle

A case of secondary pulmonary alveolar proteinosis associated with myelodysplastic syndrome, complicated with disseminated M. abscessus infection

Asai, Y., Ouchi, H., Ohosima, T., Nakano, R., Yamano, Y., Inoshima, I., Yamauchi, T., Fukuyama, S., Inoue, H. & Nakanishi, Y., Dec 2009, In : Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society. 47, 12, p. 1120-1125 6 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Acquired initiating mutations in early hematopoietic cells of CLL patients

Damm, F., Mylonas, E., Cosson, A., Yoshida, K., Della Valle, V., Mouly, E., Diop, M., Scourzic, L., Shiraishi, Y., Chiba, K., Tanaka, H., Miyano, S., Kikushige, Y., Davi, F., Lambert, J., Gautheret, D., Merle-Béral, H., Sutton, L., Dessen, P., Solary, E. & 7 others, Akashi, K., Vainchenker, W., Mercher, T., Droin, N., Ogawa, S., Nguyen-Khac, F. & Bernard, O. A., Sep 2014, In : Cancer Discovery. 4, 9, p. 1088-1101 14 p.

Research output: Contribution to journalArticle

133 Citations (Scopus)

Acute lymphoblastic leukemia presenting with calcineurin-inhibitor induced pain syndrome after a second allogeneic bone marrow transplantation

Takashima, S., Numata, A., Miyamoto, T., Shirakawa, T., Kinoshita, R., Kato, K., Takenaka, K., Harada, N., Nagafuji, K., Taniguchi, S. & Harada, M., Oct 2006, In : [Rinshō ketsueki] The Japanese journal of clinical hematology. 47, 10, p. 1372-1376 5 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Additional acquisition of t(1;21)(p32;q22) in a patient relapsing with acute myelogenous leukemia with NUP98-HOXA9

Aoki, T., Miyamoto, T., Yoshida, S., Yamamoto, A., Yamauchi, T., Yoshimoto, G., Mori, Y., Kamezaki, K., Iwasaki, H., Takenaka, K., Harada, N., Nagafuji, K., Teshima, T. & Akashi, K., Dec 1 2009, In : International journal of hematology. 88, 5, p. 571-574 4 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Allogeneic unrelated bone marrow transplantation from older donors results in worse prognosis in recipients with aplastic anemia

Japan Society for Hematopoietic Cell Transplantation, Apr 30 2016, In : Haematologica. 101, 5, p. 644-652 9 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

A multinational, open-label, phase 2 study of ruxolitinib in Asian patients with myelofibrosis: Japanese subset analysis

Oritani, K., Okamoto, S., Tauchi, T., Saito, S., Ohishi, K., Handa, H., Takenaka, K., Gopalakrishna, P., Amagasaki, T., Ito, K. & Akashi, K., Mar 6 2015, In : International journal of hematology. 101, 3, p. 295-304 10 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Analysis of GNA13 Protein in Follicular Lymphoma and its Association with Poor Prognosis

Shimono, J., Miyoshi, H., Yoshida, N., Kato, T., Sato, K., Sugio, T., Miyawaki, K., Kurita, D., Sasaki, Y., Kawamoto, K., Imaizumi, Y., Kato, K., Nagafuji, K., Akashi, K., Seto, M., Teshima, T. & Ohshima, K., Nov 1 2018, In : American Journal of Surgical Pathology. 42, 11, p. 1466-1471 6 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

A novel filtration method for cord blood processing using a polyester fabric filter

Shima, T., Forraz, N., Sato, N., Yamauchi, T., Iwasaki, H., Takenaka, K., Akashi, K., Mcguckin, C. & Teshima, T., Aug 2013, In : International Journal of Laboratory Hematology. 35, 4, p. 436-446 11 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Antiemetic effectiveness and safety of aprepitant in patients with hematologic malignancy receiving multiday chemotherapy

Uchida, M., Ikesue, H., Kato, K., Ichinose, K., Hiraiwa, H., Sakurai, A., Takenaka, K., Iwasaki, H., Miyamoto, T., Teshima, T., Egashira, N., Akashi, K. & Oishi, R., Feb 15 2013, In : American Journal of Health-System Pharmacy. 70, 4, p. 343-349 7 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Antiemetic efficacy and safety of granisetron or palonosetron alone and in combination with a corticosteroid for ABVD therapy-induced nausea and vomiting

Uchida, M., Nakamura, T., Hata, K., Watanabe, H., Mori, Y., Kato, K., Kamezaki, K., Takenaka, K., Shiratsuchi, M., Hosohata, K., Miyamoto, T. & Akashi, K., Jan 9 2018, In : Journal of Pharmaceutical Health Care and Sciences. 4, 1, 1.

Research output: Contribution to journalArticle

Open Access

Anti-GPRC5D/CD3 bispecific T-cell-redirecting antibody for the treatment of multiple myeloma

Kodama, T., Kochi, Y., Nakai, W., Mizuno, H., Baba, T., Habu, K., Sawada, N., Tsunoda, H., Shima, T., Miyawaki, K., Kikushige, Y., Mori, Y., Miyamoto, T., Maeda, T. & Akashi, K., 2019, In : Molecular cancer therapeutics. 18, 9, p. 1555-1564 10 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Ascites retention during mogamulizumab treatment in a patient with adult T-cell leukemia/lymphoma

Shima, T., Kamezaki, K., Higashioka, K., Takashima, S., Yoshimoto, G., Kato, K., Muta, T., Takenaka, K., Iwasaki, H., Miyamoto, T. & Akashi, K., Jan 1 2016, In : Internal Medicine. 55, 13, p. 1793-1796 4 p.

Research output: Contribution to journalArticle

A TIM-3/Gal-9 Autocrine Stimulatory Loop Drives Self-Renewal of Human Myeloid Leukemia Stem Cells and Leukemic Progression

Kikushige, Y., Miyamoto, T., Yuda, J., Jabbarzadeh-Tabrizi, S., Shima, T., Takayanagi, S. I., Niiro, H., Yurino, A., Miyawaki, K., Takenaka, K., Iwasaki, H. & Akashi, K., Sep 3 2015, In : Cell stem cell. 17, 3, p. 341-352 12 p., 1815.

Research output: Contribution to journalArticle

65 Citations (Scopus)

Calreticulin mutation does not contribute to disease progression in essential thrombocythemia by inhibiting phagocytosis

Daitoku, S., Takenaka, K., Yamauchi, T., Yurino, A., Jinnouchi, F., Nunomura, T., Eto, T., Kamimura, T., Higuchi, M., Harada, N., Saito, N., Miyamoto, T., Iwasaki, H. & Akashi, K., Sep 1 2016, In : Experimental Hematology. 44, 9, p. 817-825.e3

Research output: Contribution to journalArticle

8 Citations (Scopus)

CCR6+ group 3 innate lymphoid cells accumulate in inflamed joints in rheumatoid arthritis and produce Th17 cytokines

Takaki-Kuwahara, A., Arinobu, Y., Miyawaki, K., Yamada, H., Tsuzuki, H., Irino, K., Ayano, M., Kimoto, Y., Mitoma, H., Akahoshi, M., Tsukamoto, H., Horiuchi, T., Niiro, H. & Akashi, K., Aug 30 2019, In : Arthritis Research and Therapy. 21, 1, 198.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

CD41 marks the initial myelo-erythroid lineage specification in adult mouse hematopoiesis: Redefinition of murine common myeloid progenitor

Miyawaki, K., Arinobu, Y., Iwasaki, H., Kohno, K., Tsuzuki, H., Iino, T., Shima, T., Kikushige, Y., Takenaka, K., Miyamoto, T. & Akashi, K., Mar 1 2015, In : STEM CELLS. 33, 3, p. 976-987 12 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Cell-based screen identifies a new potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth

Oshima, T., Niwa, Y., Kuwata, K., Srivastava, A., Hyoda, T., Tsuchiya, Y., Kumagai, M., Tsuyuguchi, M., Tamaru, T., Sugiyama, A., Ono, N., Zolboot, N., Aikawa, Y., Oishi, S., Nonami, A., Arai, F., Hagihara, S., Yamaguchi, J., Tama, F., Kunisaki, Y. & 6 others, Yagita, K., Ikeda, M., Kinoshita, T., Kay, S. A., Itami, K. & Hirota, T., Jan 23 2019, In : Science Advances. 5, 1, eaau9060.

Research output: Contribution to journalArticle

Open Access
17 Citations (Scopus)

Chemotherapy-induced bone marrow nerve injury impairs hematopoietic regeneration

Lucas, D., Scheiermann, C., Chow, A., Kunisaki, Y., Bruns, I., Barrick, C., Tessarollo, L. & Frenette, P. S., Jun 1 2013, In : Nature medicine. 19, 6, p. 695-703 9 p.

Research output: Contribution to journalArticle

127 Citations (Scopus)

CIN85 is required for Cbl-mediated regulation of antigen receptor signaling in human B cells

Niiro, H., Jabbarzadeh-Tabrizi, S., Kikushige, Y., Shima, T., Noda, K., Ota, S. I., Tsuzuki, H., Inoue, Y., Arinobu, Y., Iwasaki, H., Shimoda, S., Baba, E., Tsukamoto, H., Horiuchi, T., Taniyama, T. & Akashi, K., Mar 8 2012, In : Blood. 119, 10, p. 2263-2273 11 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Clinical features and treatment outcomes of isolated secondary central nervous system lymphomas in Miyazaki Prefecture

Kawano, N., Ochiai, H., Yoshida, S., Yamashita, K., Shide, K., Shimoda, H., Hidaka, T., Kubuki, Y., Katayose, K., Toyama, T., Kawano, H., Matsuoka, H., Ishizaki, J., Maeda, K., Satou, S., Yano, T., Yamaguchi, K., Takenaka, K., Shimao, Y., Oshima, K. & 2 others, Ueda, A. & Shimoda, K., Aug 1 2012, In : International Journal of Clinical Oncology. 17, 4, p. 336-340 5 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Clinical profiles of 7 patients with chronic myelogenous leukemia or Philadelphia chromosome-positive acute lymphoblastic leukemia treated with dasatinib

Hoshino, T., Tahara, K., Miyawaki, K., Hatsumi, N., Takada, S., Miyawaki, S. & Sakura, T., Jan 1 2010, In : [Rinshō ketsueki] The Japanese journal of clinical hematology. 51, 3, p. 181-188 8 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Clinicopathological features of HCV-positive splenic diffuse large B cell lymphoma

Shimono, J., Miyoshi, H., Arakawa, F., Yamada, K., Sugio, T., Miyawaki, K., Eto, T., Miyagishima, T., Kato, K., Nagafuji, K., Akashi, K., Teshima, T. & Ohshima, K., May 1 2019, In : Annals of Hematology. 98, 5, p. 1197-1207 11 p.

Research output: Contribution to journalArticle

Collection of mobilized peripheral blood stem cells from a donor with severe iron deficient anemia

Kamezaki, K., Miyamoto, T., Henzan, T., Numata, A., Iwasaki, H., Nagafuji, K., Harada, M., Teshima, T. & Akashi, K., Nov 1 2007, In : Journal of Clinical Apheresis. 22, 5, p. 292-294 3 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Combination of bortezomib, thalidomide, and dexamethasone (VTD) as a consolidation therapy after autologous stem cell transplantation for symptomatic multiple myeloma in Japanese patients

Takashima, S., Miyamoto, T., Kadowaki, M., Ito, Y., Aoki, T., Takase, K., Shima, T., Yoshimoto, G., Kato, K., Muta, T., Shiratsuchi, M., Takenaka, K., Iwasaki, H., Teshima, T., Kamimura, T. & Akashi, K., Aug 2014, In : International journal of hematology. 100, 2, p. 159-164 6 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Combination of high-dose melphalan and bortezomib as conditioning regimen for autologous peripheral blood stem cell transplantation in multiple myeloma

Miyamoto, T., Yoshimoto, G., Kamimura, T., Muta, T., Takashima, S., Ito, Y., Shiratsuchi, M., Choi, I., Kato, K., Takenaka, K., Iwasaki, H., Takamatsu, Y., Teshima, T. & Akashi, K., Sep 2013, In : International journal of hematology. 98, 3, p. 337-345 9 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Comparison between antiemetic effects of palonosetron and granisetron on chemotherapy-induced nausea and vomiting in Japanese patients treated with R-CHOP

Uchida, M., Mori, Y., Nakamura, T., Kato, K., Kamezaki, K., Takenaka, K., Shiratsuchi, M., Kadoyama, K., Miyamoto, T. & Akashi, K., 2017, In : Biological and Pharmaceutical Bulletin. 40, 9, p. 1499-1505 7 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Composite lymphoma of peripheral T-cell lymphoma and Hodgkin lymphoma, mixed cellularity type; pathological and molecular analysis

Ichikawa, A., Miyoshi, H., Yamauchi, T., Arakawa, F., Kawano, R., Muta, H., Sugita, Y., Akashi, K. & Ohshima, K., Apr 1 2017, In : Pathology International. 67, 4, p. 194-201 8 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Contribution of Bone Marrow-Derived Hematopoietic Stem/Progenitor Cells to the Generation of Donor-Marker+ Cardiomyocytes In Vivo

Fukata, M., Ishikawa, F., Najima, Y., Yamauchi, T., Saito, Y., Takenaka, K., Miyawaki, K., Shimazu, H., Shimoda, K., Kanemaru, T., Nakamura, K. I., Odashiro, K., Nagafuji, K., Harada, M. & Akashi, K., May 7 2013, In : PloS one. 8, 5, e62506.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Cord blood transplantation following reduced-intensity conditioning for adult-onset inherited hemophagocytic lymphohistiocytosis

Kuriyama, T., Kato, K., Sakamoto, K., Hayashi, M., Takashima, S., Mori, Y., Takenaka, K., Iwasaki, H., Teshima, T., Harada, N., Nagafuji, K., Miyamoto, T. & Akashi, K., Mar 15 2016, In : Internal Medicine. 55, 6, p. 667-671 5 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

CRISPRO: Identification of functional protein coding sequences based on genome editing dense mutagenesis Jin-Soo Kim

Schoonenberg, V. A. C., Cole, M. A., Yao, Q., MacIas-Treviño, C., Sher, F., Schupp, P. G., Canver, M. C., Maeda, T., Pinello, L. & Bauer, D. E., Oct 19 2018, In : Genome biology. 19, 1, 169.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Cytomegalovirus Reactivation after Allogeneic Hematopoietic Stem Cell Transplantation is Associated with a Reduced Risk of Relapse in Patients with Acute Myeloid Leukemia Who Survived to Day 100 after Transplantation: The Japan Society for Hematopoietic Cell Transplantation Transplantation-related Complication Working Group

Takenaka, K., Nishida, T., Asano-Mori, Y., Oshima, K., Ohashi, K., Mori, T., Kanamori, H., Miyamura, K., Kato, C., Kobayashi, N., Uchida, N., Nakamae, H., Ichinohe, T., Morishima, Y., Suzuki, R., Yamaguchi, T. & Fukuda, T., Nov 2015, In : Biology of Blood and Marrow Transplantation. 21, 11, p. 2008-2016 9 p.

Research output: Contribution to journalArticle

65 Citations (Scopus)
1 Citation (Scopus)

Decrease in venous irritation by adjusting the concentration of injected bendamustine

Watanabe, H., Ikesue, H., Tsujikawa, T., Nagata, K., Uchida, M., Suetsugu, K., Egashira, N., Muta, T., Kato, K., Takenaka, K., Ohga, S., Matsushima, T., Shiratsuchi, M., Miyamoto, T., Teshima, T., Akashi, K. & Oishi, R., Apr 2013, In : Biological and Pharmaceutical Bulletin. 36, 4, p. 574-578 5 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Dedifferentiation process driven by TGF-beta signaling enhances stem cell properties in human colorectal cancer

Nakano, M., Kikushige, Y., Miyawaki, K., Kunisaki, Y., Mizuno, S., Takenaka, K., Tamura, S., Okumura, Y., Ito, M., Ariyama, H., Kusaba, H., Nakamura, M., Maeda, T., Baba, E. & Akashi, K., Feb 7 2019, In : Oncogene. 38, 6, p. 780-793 14 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Deletion of DOCK2, a regulator of the actin cytoskeleton in lymphocytes, suppresses cardiac allograft rejection

Jiang, H., Pan, F., Erickson, L. M., Jang, M. S., Sanui, T., Kunisaki, Y., Sasazuki, T., Kobayashi, M. & Fukui, Y., Oct 17 2005, In : Journal of Experimental Medicine. 202, 8, p. 1121-1130 10 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)
4 Citations (Scopus)

Development of ET, primary myelofibrosis and PV in mice expressing JAK2 V617F

Shide, K., Shimoda, H. K., Kumano, T., Karube, K., Kameda, T., Takenaka, K., Oku, S., Abe, H., Katayose, K. S., Kubuki, Y., Kusumoto, K., Hasuike, S., Tahara, Y., Nagata, K., Matsuda, T., Ohshima, K., Harada, M. & Shimoda, K., Jan 1 2008, In : Leukemia. 22, 1, p. 87-95 9 p.

Research output: Contribution to journalArticle

121 Citations (Scopus)

Diagnostic value of serum procalcitonin and C-reactive protein for infections after allogeneic hematopoietic stem cell transplantation versus nontransplant setting

Mori, Y., Miyawaki, K., Kato, K., Takenaka, K., Iwasaki, H., Harada, N., Miyamoto, T., Akashi, K. & Teshima, T., Oct 11 2011, In : Internal Medicine. 50, 19, p. 2149-2155 7 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Differential requirements for DOCK2 and phosphoinositide-3-kinase γ during T and B lymphocyte homing

Nombela-Arrieta, C., Lacalle, R. A., Montoya, M. C., Kunisaki, Y., Megías, D., Marqués, M., Carrera, A. C., Mañes, S., Fukui, Y., Martínez-A, C. & Stein, J. V., Sep 1 2004, In : Immunity. 21, 3, p. 429-441 13 p.

Research output: Contribution to journalArticle

188 Citations (Scopus)

Different Risk Factors Related to Adenovirus- or BK Virus-Associated Hemorrhagic Cystitis following Allogeneic Stem Cell Transplantation

Mori, Y., Miyamoto, T., Kato, K., Kamezaki, K., Kuriyama, T., Oku, S., Takenaka, K., Iwasaki, H., Harada, N., Shiratsuchi, M., Abe, Y., Nagafuji, K., Teshima, T. & Akashi, K., Mar 1 2012, In : Biology of Blood and Marrow Transplantation. 18, 3, p. 458-465 8 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

Diffuse panbronchiolitis after humanized anti-CCR4 monoclonal antibody therapy for relapsed adult T-cell leukemia/lymphoma

Kato, K., Miyamoto, T., Numata, A., Nakaike, T., Oka, H., Yurino, A., Kuriyama, T., Mori, Y., Yamasaki, S., Muta, T., Takenaka, K., Iwasaki, H., Teshima, T. & Akashi, K., Mar 1 2013, In : International journal of hematology. 97, 3, p. 430-432 3 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Direct evidence for cooperating genetic events in the leukemic transformation of normal human hematopoietic cells

Warner, J. K., Wang, J. C. Y., Takenaka, K., Doulatov, S., McKenzie, J. L., Harrington, L. & Dick, J. E., Oct 2005, In : Leukemia. 19, 10, p. 1794-1805 12 p.

Research output: Contribution to journalArticle

81 Citations (Scopus)

Disseminated tuberculosis following second unrelated cord blood transplantation for acute myelogenous leukemia

Shima, T., Yoshimoto, G., Miyamoto, T., Yoshida, S., Kamezaki, K., Takenaka, K., Iwasaki, H., Harada, N., Nagafuji, K., Teshima, T., Shimono, N. & Akashi, K., Feb 1 2009, In : Transplant Infectious Disease. 11, 1, p. 75-77 3 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Distinctive expression of myelomonocytic markers and down-regulation of CD34 in acute myelogenous leukaemia with FLT3 tandem duplication and nucleophosmin mutation

Mori, Y., Yoshimoto, G., Kumano, T., Miyamoto, T., Iino, T., Takenaka, K., Iwasaki, H., Harada, N., Kinukawa, N., Nagafuji, K., Teshima, T., Shimoda, K., Akashi, K. & Harada, M., Jul 1 2007, In : European Journal of Haematology. 79, 1, p. 17-24 8 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

DOCK2 is a Rac activator that regulates motility and polarity during neutrophil chemotaxis

Kunisaki, Y., Nishikimi, A., Tanaka, Y., Takii, R., Noda, M., Inayoshi, A., Watanabe, K. I., Sanematsu, F., Sasazuki, T., Sasaki, T. & Fukui, Y., Aug 28 2006, In : Journal of Cell Biology. 174, 5, p. 647-652 6 p.

Research output: Contribution to journalArticle

145 Citations (Scopus)