Comprehensive Clinical Oncology

Research Output 1992 2019

2019
6 Citations (Scopus)

Dedifferentiation process driven by TGF-beta signaling enhances stem cell properties in human colorectal cancer

Nakano, M., Kikushige, Y., Miyawaki, K., Kunisaki, Y., Mizuno, S., Takenaka, K., Tamura, S., Okumura, Y., Ito, M., ariyama, H., Kusaba, H., Nakamura, M., Maeda, T., Baba, E. & Akashi, K., Feb 7 2019, In : Oncogene. 38, 6, p. 780-793 14 p.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Transforming Growth Factor beta
Colorectal Neoplasms
Stem Cells
Organoids

Efficacy and safety of ramucirumab plus modified FOLFIRI for metastatic colorectal cancer

Yoshihiro, T., Kusaba, H., Makiyama, A., Kobayashi, K., Uenomachi, M., Ito, M., Doi, Y., Mitsugi, K., Aikawa, T., Takayoshi, K., Esaki, T., Shimokawa, H., Tsuchihashi, K., ariyama, H., Akashi, K. & Baba, E., May 15 2019, In : International Journal of Clinical Oncology. 24, 5, p. 508-515 8 p.

Research output: Contribution to journalArticle

Colorectal Neoplasms
Safety
irinotecan
Confidence Intervals
ramucirumab

Genetic Profiling of Non-Small Cell Lung Cancer at Development of Resistance to First- or Second-Generation EGFR-TKIs by CAPP-Seq Analysis of Circulating Tumor DNA

Otsubo, K., Sakai, K., Takeshita, M., Harada, D., Azuma, K., Ota, K., Akamatsu, H., Goto, K., Horiike, A., Kurata, T., Nakagaki, N., Nosaki, K., Iwama, E., Nakanishi, Y., Nishio, K. & Okamoto, I., Jan 1 2019, In : Oncologist.

Research output: Contribution to journalArticle

High-Throughput Nucleotide Sequencing
Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
DNA

Hypoalbuminemia for the prediction of venous thromboembolism and treatment of direct oral anticoagulants in metastatic gastric cancer patients

Takayoshi, K., Kusaba, H., Aikawa, T., Koreishi, S., Sagara, K., Nakano, M., Komoda, M., Kono, M., Fukata, M., Arita, T., Esaki, T., Akashi, K. & Baba, E., Jan 1 2019, In : Gastric Cancer.

Research output: Contribution to journalArticle

Hypoalbuminemia
Venous Thromboembolism
Anticoagulants
Stomach Neoplasms
Therapeutics

Identification of genomic alterations acquired during treatment with EGFR-TKIs in non-small cell lung cancer

Kubo, N., Harada, T., Shiraishi, Y., Nosaki, K., Nakagaki, N., Takeshita, M., Ouchi, H., Iwama, E., Tanaka, K., Okamoto, I., Sasaki, H. & Nakanishi, Y., Feb 1 2019, In : Anticancer research. 39, 2, p. 671-677 7 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
Therapeutics
Exome
5 Citations (Scopus)

Pan-Asian adapted ESMO Clinical Practice Guidelines for the management of patients with metastatic gastric cancer: A JSMO-ESMO initiative endorsed by CSCO, KSMO, MOS, SSO and TOS

Muro, K., Van Cutsem, E., Narita, Y., Pentheroudakis, G., Baba, E., Li, J., Ryu, M. H., Wan Zamaniah, W. I., Yong, W. P., Yeh, K. H., Kato, K., Lu, Z., Cho, B. C., Nor, I. M., Ng, M., Chen, L. T., Nakajima, T. E., Shitara, K., Kawakami, H., Tsushima, T. & 8 othersYoshino, T., Lordick, F., Martinelli, E., Smyth, E. C., Arnold, D., Minami, H., Tabernero, J. & Douillard, J. Y., Jan 1 2019, In : Annals of Oncology. 30, 1, p. 19-33 15 p.

Research output: Contribution to journalArticle

Open Access
Medical Oncology
Practice Management
Singapore
Practice Guidelines
Stomach Neoplasms
3 Citations (Scopus)

Pan-Asian adapted ESMO Clinical Practice Guidelines for the management of patients with metastatic oesophageal cancer: A JSMO-ESMO initiative endorsed by CSCO, KSMO, MOS, SSO and TOS

Muro, K., Lordick, F., Tsushima, T., Pentheroudakis, G., Baba, E., Lu, Z., Cho, B. C., Nor, I. M., Ng, M., Chen, L. T., Kato, K., Li, J., Ryu, M. H., Wan Zamaniah, W. I., Yong, W. P., Yeh, K. H., Nakajima, T. E., Shitara, K., Kawakami, H., Narita, Y. & 8 othersYoshino, T., Van Cutsem, E., Martinelli, E., Smyth, E. C., Arnold, D., Minami, H., Tabernero, J. & Douillard, J. Y., Jan 1 2019, In : Annals of Oncology. 30, 1, p. 34-43 10 p.

Research output: Contribution to journalArticle

Open Access
Medical Oncology
Practice Management
Singapore
Esophageal Neoplasms
Practice Guidelines

Safety and efficacy of PD-1 inhibitors in non–small cell lung cancer patients positive for antinuclear antibodies

Yoneshima, Y., Tanaka, K., Shiraishi, Y., Hata, K., Watanabe, H., Harada, T., Otsubo, K., Iwama, E., Inoue, H., Masuda, S., Nakanishi, Y. & Okamoto, I., Apr 1 2019, In : Lung Cancer. 130, p. 5-9 5 p.

Research output: Contribution to journalArticle

Antinuclear Antibodies
Non-Small Cell Lung Carcinoma
Safety
Autoimmune Diseases
Disease-Free Survival
2018
4 Citations (Scopus)

Activation of central/effector memory T cells and T-helper 1 polarization in malignant melanoma patients treated with anti-programmed death-1 antibody

Yamaguchi, K., Mishima, K., Ohmura, H., Hanamura, F., Ito, M., Nakano, M., Tsuchihashi, K., Ota, S. I., Wada, N., Hiroshi, U., ariyama, H., Kusaba, H., Niiro, H., Akashi, K. & Baba, E., Oct 1 2018, In : Cancer Science. 109, 10, p. 3032-3042 11 p.

Research output: Contribution to journalArticle

Th1 Cells
Melanoma
T-Lymphocytes
Antibodies
Phenotype
1 Citation (Scopus)

Alkaline Phosphatase-Catalyzed Amplification of a Fluorescence Signal for Flow Cytometry

Nobori, T., Tosaka, K., Kawamura, A., Joichi, T., Kamino, K., Kishimura, A., Baba, E., Mori, T. & Katayama, Y., Jan 16 2018, In : Analytical Chemistry. 90, 2, p. 1059-1062 4 p.

Research output: Contribution to journalArticle

Flow cytometry
Amplification
Alkaline Phosphatase
Fluorescence
Fluorophores

A phase 2 study of fosaprepitant combined with high-dose dexamethasone for Japanese cancer patients receiving highly emetogenic chemotherapy

Kumagai, H., Kusaba, H., Yamanaka, T., Nio, K., Inadomi, K., Takayoshi, K., Ito, M., Tamura, S., Makiyama, A., Makiyama, C., Hirano, G., Shibata, Y., Shirakawa, T., Mitsugi, K., ariyama, H., Esaki, T., Akashi, K. & Baba, E., Jun 1 2018, In : Medicine (United States). 97, 25, e11042.

Research output: Contribution to journalArticle

fosaprepitant
Dexamethasone
Antiemetics
Drug Therapy
Neoplasms

Association of nephrotoxicity during platinum-etoposide doublet therapy with UGT1A1 polymorphisms in small cell lung cancer patients

Anai, S., Iwama, E., Yoneshima, Y., Otsubo, K., Tanaka, K., Nakanishi, Y. & Okamoto, I., Dec 1 2018, In : Lung Cancer. 126, p. 156-161 6 p.

Research output: Contribution to journalArticle

Small Cell Lung Carcinoma
Etoposide
Platinum
Alleles
irinotecan
1 Citation (Scopus)

Combined therapy with epidermal growth factor receptor tyrosine kinase inhibitors for non–small cell lung cancer

Iwama, E., Nakanishi, Y. & Okamoto, I., Mar 4 2018, In : Expert Review of Anticancer Therapy. 18, 3, p. 267-276 10 p.

Research output: Contribution to journalReview article

Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
Mutation
Therapeutics

Detection of identical T cell clones in peritumoral pleural effusion and pneumonitis lesions in a cancer patient during immune-checkpoint blockade

Tanaka, K., Yanagihara, T., Ikematsu, Y., Inoue, H., ota, K., Kashiwagi, E., Suzuki, K., Hamada, N., takeuchi, A., Tatsugami, K., Eto, M., Ijichi, K., Oda, Y., Otsubo, K., Yoneshima, Y., Iwama, E., Nakanishi, Y. & Okamoto, I., Jul 17 2018, In : Oncotarget. 9, 55, p. 30587-30593 7 p.

Research output: Contribution to journalArticle

Bronchoalveolar Lavage Fluid
Pleural Effusion
Pneumonia
Clone Cells
T-Cell Antigen Receptor
1 Citation (Scopus)

E-cadherin regulates proliferation of colorectal cancer stem cells through NANOG

Tamura, S., Isobe, T., ariyama, H., Nakano, M., Kikushige, Y., Takaishi, S., Kusaba, H., Takenaka, K., Ueki, T., Nakamura, M., Akashi, K. & Baba, E., Aug 1 2018, In : Oncology reports. 40, 2, p. 693-703 11 p.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Cadherins
Colorectal Neoplasms
Cyclin D1
Embryonic Stem Cells
1 Citation (Scopus)

Epidermal growth factor receptor promotes glioma progression by regulating xCT and GluN2B-containing N-methyl-d-aspartate–sensitive glutamate receptor signaling

Suina, K., Tsuchihashi, K., Yamasaki, J., Kamenori, S., Shintani, S., Hirata, Y., Okazaki, S., Sampetrean, O., Baba, E., Akashi, K., Mitsuishi, Y., Takahashi, F., Takahashi, K., Saya, H. & Nagano, O., Dec 1 2018, In : Cancer Science. 109, 12, p. 3874-3882 9 p.

Research output: Contribution to journalArticle

Glutamate Receptors
Epidermal Growth Factor Receptor
Glioma
Glutamic Acid
Epidermal Growth Factor

Epithelial-mesenchymal transition is activated in CD44-positive malignant ascites tumor cells of gastrointestinal cancer

Nakano, M., Ito, M., Tanaka, R., ariyama, H., Mitsugi, K., Makiyama, A., Uchino, K., Esaki, T., Tsuruta, N., Hanamura, F., Yamaguchi, K., Okumura, Y., Sagara, K., Takayoshi, K., Nio, K., Tsuchihashi, K., Tamura, S., Shimokawa, H., Arita, S., Miyawaki, K. & 3 othersKusaba, H., Akashi, K. & Baba, E., Nov 1 2018, In : Cancer Science. 109, 11, p. 3461-3470 10 p.

Research output: Contribution to journalArticle

Gastrointestinal Neoplasms
Epithelial-Mesenchymal Transition
Ascites
Neoplasms
Transforming Growth Factor beta

Exploration of resistance mechanisms for epidermal growth factor receptor-tyrosine kinase inhibitors based on plasma analysis by digital polymerase chain reaction and next-generation sequencing

Iwama, E., Sakai, K., Azuma, K., Harada, D., Nosaki, K., Hotta, K., Nishio, M., Kurata, T., Fukuhara, T., Akamatsu, H., Goto, K., Shimose, T., Kishimoto, J., Nakanishi, Y., Nishio, K. & Okamoto, I., Dec 1 2018, In : Cancer Science. 109, 12, p. 3921-3933 13 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Protein-Tyrosine Kinases
Polymerase Chain Reaction
Mutation
Neoplasms

Expression of brain-derived neurotrophic factor and its receptor TrkB is associated with poor prognosis and a malignant phenotype in small cell lung cancer

Kimura, S., Harada, T., Ijichi, K., Tanaka, K., Liu, R., Shibahara, D., Kawano, Y., Otsubo, K., Yoneshima, Y., Iwama, E., Nakanishi, Y. & Okamoto, I., Jun 1 2018, In : Lung Cancer. 120, p. 98-107 10 p.

Research output: Contribution to journalArticle

trkB Receptor
Brain-Derived Neurotrophic Factor
Small Cell Lung Carcinoma
Phenotype
Non-Small Cell Lung Carcinoma
1 Citation (Scopus)

First-line chemotherapy with S-1 alone or S-1 plus cisplatin for elderly patients with advanced gastric cancer: a multicenter propensity score matched study

Makiyama, A., Kunieda, K., Noguchi, M., Kajiwara, T., Tamura, T., Takeda, K., Sugiyama, J., Minashi, K., Moriwaki, T., Sugimoto, N., Nagase, M., Negoro, Y., Tsuda, T., Shimodaira, H., Okano, N., Tsuji, A., Sakai, D., Yanagihara, K., Ueda, S., Tamura, S. & 15 othersOtsu, S., Honda, T., Matsushita, Y., Okuno, T., Kashiwada, T., Nozaki, A., Ebi, M., Okuda, H., Shimokawa, M., Hironaka, S., Hyodo, I., Baba, E., Boku, N., Muro, K. & Esaki, T., Sep 1 2018, In : Gastric Cancer. 21, 5, p. 792-801 10 p.

Research output: Contribution to journalArticle

Propensity Score
Cisplatin
Stomach Neoplasms
Drug Therapy
Geriatric Assessment
3 Citations (Scopus)

Intrinsic and Extrinsic Regulation of PD-L2 Expression in Oncogene-Driven Non–Small Cell Lung Cancer

Shibahara, D., Tanaka, K., Iwama, E., Kubo, N., ota, K., Azuma, K., Harada, T., Fujita, J., Nakanishi, Y. & Okamoto, I., Jul 1 2018, In : Journal of Thoracic Oncology. 13, 7, p. 926-937 12 p.

Research output: Contribution to journalArticle

Oncogenes
Non-Small Cell Lung Carcinoma
Cell Death
Ligands
STAT3 Transcription Factor
3 Citations (Scopus)

Irinotecan monotherapy as third-line or later treatment in advanced gastric cancer

Makiyama, A., Arimizu, K., Hirano, G., Makiyama, C., Matsushita, Y., Shirakawa, T., Ohmura, H., Komoda, M., Uchino, K., Inadomi, K., Arita, S., ariyama, H., Kusaba, H., Shinohara, Y., Kuwayama, M., Kajitani, T., Oda, H., Esaki, T., Akashi, K. & Baba, E., May 1 2018, In : Gastric Cancer. 21, 3, p. 464-472 9 p.

Research output: Contribution to journalArticle

irinotecan
Stomach Neoplasms
Salvage Therapy
Therapeutics
Survival

Metastatic esophageal carcinosarcoma comprising neuroendocrine carcinoma, squamous cell carcinoma, and sarcoma A case report

Tsuchihashi, K., Arita, S., Fujiwara, M., Iwasaki, K., Hirano, A., Yoshihiro, T., Nio, K., Koga, Y., Esaki, M., ariyama, H., Kusaba, H., Moriyama, T., Ouchida, K., Nagai, E., Nakamura, M., Oda, Y., Akashi, K. & Baba, E., Oct 1 2018, In : Medicine (United States). 97, 41, e12796.

Research output: Contribution to journalArticle

Carcinosarcoma
Neuroendocrine Carcinoma
Sarcoma
Squamous Cell Carcinoma
Etoposide

PD-1+ TIM-3+ T cells in malignant ascites predict prognosis of gastrointestinal cancer

Nakano, M., Ito, M., Tanaka, R., Yamaguchi, K., ariyama, H., Mitsugi, K., Yoshihiro, T., Ohmura, H., Tsuruta, N., Hanamura, F., Sagara, K., Okumura, Y., Nio, K., Tsuchihashi, K., Arita, S., Kusaba, H., Akashi, K. & Baba, E., Sep 1 2018, In : Cancer Science. 109, 9, p. 2986-2992 7 p.

Research output: Contribution to journalArticle

Tumor-Infiltrating Lymphocytes
Gastrointestinal Neoplasms
Ascites
Cell Death
T-Lymphocytes
10 Citations (Scopus)

PD-L1 expression in lung adenocarcinoma harboring EGFR mutations or ALK rearrangements

Yoneshima, Y., Ijichi, K., Anai, S., ota, K., Otsubo, K., Iwama, E., Tanaka, K., Oda, Y., Nakanishi, Y. & Okamoto, I., Apr 1 2018, In : Lung Cancer. 118, p. 36-40 5 p.

Research output: Contribution to journalArticle

Mutation
Neoplasms
Adenocarcinoma of lung
Protein-Tyrosine Kinases
Oncogenes
1 Citation (Scopus)
Therapeutic Uses
Platinum
Non-Small Cell Lung Carcinoma
Perfusion
Tomography
19 Citations (Scopus)

Propensity Score Analysis of Regorafenib Versus Trifluridine/Tipiracil in Patients with Metastatic Colorectal Cancer Refractory to Standard Chemotherapy (REGOTAS): A Japanese Society for Cancer of the Colon and Rectum Multicenter Observational Study

Moriwaki, T., Fukuoka, S., Taniguchi, H., Takashima, A., Kumekawa, Y., Kajiwara, T., Yamazaki, K., Esaki, T., Makiyama, C., Denda, T., Satake, H., Suto, T., Sugimoto, N., Enomoto, M., Ishikawa, T., Kashiwada, T., Sugiyama, M., Komatsu, Y., Okuyama, H., Baba, E. & 6 othersSakai, D., Watanabe, T., Tamura, T., Yamashita, K., Gosho, M. & Shimada, Y., Jan 1 2018, In : Oncologist. 23, 1, p. 7-15 9 p.

Research output: Contribution to journalArticle

Trifluridine
Propensity Score
Rectal Neoplasms
Colonic Neoplasms
Multicenter Studies
1 Citation (Scopus)

Role of Predictive Value of the Modified Glasgow Prognostic Score for Later-line Chemotherapy in Patients With Metastatic Colorectal Cancer

Tsuchihashi, K., Ito, M., Moriwaki, T., Fukuoka, S., Taniguchi, H., Takashima, A., Kumekawa, Y., Kajiwara, T., Yamazaki, K., Esaki, T., Makiyama, A., Denda, T., Satake, H., Suto, T., Sugimoto, N., Katsumata, K., Ishikawa, T., Kashiwada, T., Oki, E., Komatsu, Y. & 8 othersOkuyama, H., Sakai, D., Ueno, H., Tamura, T., Yamashita, K., Kishimoto, J., Shimada, Y. & Baba, E., Dec 1 2018, In : Clinical Colorectal Cancer. 17, 4, p. e687-e697

Research output: Contribution to journalArticle

Colorectal Neoplasms
Drug Therapy
Confidence Intervals
Disease-Free Survival
Survival

Stereotactic body radiotherapy to treat small lung lesions clinically diagnosed as primary lung cancer by radiological examination: A prospective observational study

Inoue, T., Katoh, N., Ito, Y. M., Kimura, T., Nagata, Y., Kuriyama, K., Onishi, H., Yoshitake, T., Shioyama, Y., Iizuka, Y., Inaba, K., Konishi, K., Kokubo, M., Karasawa, K., Kozuka, T., Tanaka, K., Sakakibara-Konishi, J., Kinoshita, I. & Shirato, H., Aug 1 2018, In : Lung Cancer. 122, p. 107-112 6 p.

Research output: Contribution to journalArticle

Radiosurgery
Observational Studies
Lung Neoplasms
Prospective Studies
Lung

Study protocol of a phase II clinical trial (KSCC1501A) examining oxaliplatin + S-1 for treatment of HER2-negative advanced/recurrent gastric cancer previously untreated with chemotherapy

Saeki, H., Emi, Y., Oki, E., Tokunaga, S., Kakeji, Y., Akagi, Y., Baba, H., Baba, E. & Maehara, Y., Jan 8 2018, In : BMC Cancer. 18, 1, 57.

Research output: Contribution to journalArticle

oxaliplatin
Phase II Clinical Trials
Stomach Neoplasms
Drug Therapy
Japan

Successful chemotherapeutic treatment for metastatic littoral cell angioma: A case report

Takayoshi, K., Doi, G., Tsuruta, N., Yoshihiro, T., Nio, K., Tsuchihashi, K., ariyama, H., Odawara, J., Shimoda, S., Kouhashi, K., Oda, Y., itoh, S., Harimoto, N., Maehara, Y., Kusaba, H., Akashi, K. & Baba, E., Apr 1 2018, In : Medicine (United States). 97, 15, e0378.

Research output: Contribution to journalArticle

Hepatomegaly
Cytotoxins
Deoxyglucose
Liver
Tomography
1 Citation (Scopus)

The risk factors for oxaliplatin-induced peripheral sensory neuropathy and thrombocytopenia in advanced gastric cancer

Yamaguchi, K., Kusaba, H., Makiyama, A., Mitsugi, K., Uchino, K., Tamura, S., Shibata, Y., Esaki, T., Ito, M., Takayoshi, K., Tsuchihashi, K., Arita, S., ariyama, H., Akashi, K. & Baba, E., Oct 1 2018, In : Cancer chemotherapy and pharmacology. 82, 4, p. 625-633 9 p.

Research output: Contribution to journalArticle

oxaliplatin
Peripheral Nervous System Diseases
Thrombocytopenia
Stomach Neoplasms
Medical problems
2017
11 Citations (Scopus)

Alectinib for Patients with ALK Rearrangement–Positive Non–Small Cell Lung Cancer and a Poor Performance Status (Lung Oncology Group in Kyushu 1401)

Iwama, E., Goto, Y., Murakami, H., Harada, T., Tsumura, S., Sakashita, H., Mori, Y., Nakagaki, N., Fujita, Y., Seike, M., Bessho, A., Ono, M., Okazaki, A., Akamatsu, H., Morinaga, R., Ushijima, S., Shimose, T., Tokunaga, S., Hamada, A., Yamamoto, N. & 3 othersNakanishi, Y., Sugio, K. & Okamoto, I., Jul 1 2017, In : Journal of Thoracic Oncology. 12, 7, p. 1161-1166 6 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Lung
Confidence Intervals
Patient Safety
CH5424802
2 Citations (Scopus)

Anti-epidermal growth factor receptor antibody readministration in chemorefractory metastatic colorectal cancer

Kajitani, T., Makiyama, A., Arita, S., Shimokawa, H., Oda, H., Shirakawa, T., Baba, E. & Esaki, T., Nov 1 2017, In : Anticancer Research. 37, 11, p. 6459-6468 10 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Colorectal Neoplasms
Antibodies
Anti-Idiotypic Antibodies
irinotecan
6 Citations (Scopus)

A phase II study of 5-fluorouracil/L-leucovorin/oxaliplatin (mFOLFOX6) in Japanese patients with metastatic or unresectable small bowel adenocarcinoma

Horimatsu, T., Nakayama, N., Moriwaki, T., Hirashima, Y., Fujita, M., Asayama, M., Moriyama, I., Nakashima, K., Baba, E., Kitamura, H., Tamura, T., Hosokawa, A., Yoshimura, K. & Muto, M., Oct 1 2017, In : International Journal of Clinical Oncology. 22, 5, p. 905-912 8 p.

Research output: Contribution to journalArticle

oxaliplatin
Leucovorin
Fluorouracil
Adenocarcinoma
Disease-Free Survival
3 Citations (Scopus)

CD44 variant–dependent regulation of redox balance in EGFR mutation–positive non–small cell lung cancer: A target for treatment

Kawano, Y., Iwama, E., Tsuchihashi, K., Shibahara, D., Harada, T., Tanaka, K., Nagano, O., Saya, H., Nakanishi, Y. & Okamoto, I., Nov 1 2017, In : Lung Cancer. 113, p. 72-78 7 p.

Research output: Contribution to journalArticle

erbB-1 Genes
Non-Small Cell Lung Carcinoma
Oxidation-Reduction
Reactive Oxygen Species
Cisplatin
1 Citation (Scopus)

Chronic myelomonocytic leukemia blast crisis in a patient with advanced non-small cell lung cancer treated with EGFR tyrosine kinase inhibitors

Ogata, H., Okamoto, I., Yoshimoto, G., Obara, T., Ijichi, K., Iwama, E., Harada, T., Akashi, K. & Nakanishi, Y., Mar 1 2017, In : Respiratory Investigation. 55, 2, p. 181-183 3 p.

Research output: Contribution to journalArticle

Leukemia, Myelomonocytic, Chronic
erbB-1 Genes
Blast Crisis
Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
1 Citation (Scopus)

Early tumor shrinkage indicates a favorable response to bevacizumab-based first-line chemotherapy for metastatic colorectal cancer

Ito, M., Kusaba, H., Mukaide, S., Kishimoto, J., Shimokawa, H., Tamura, S., Makiyama, A., Hirano, G., Oda, H., Shirakawa, T., Komoda, M., Uchino, K., Tanaka, R., Mitsugi, K., Esaki, T., Arita, S., ariyama, H., Akashi, K. & Baba, E., Jan 1 2017, In : Anti-cancer drugs. 28, 10, p. 1166-1173 8 p.

Research output: Contribution to journalArticle

Colorectal Neoplasms
Drug Therapy
Survival
Neoplasms
Growth Factor Receptors

Interleukin-22 attenuates double-stranded RNA-induced upregulation of PD-L1 in airway epithelial cells via a STAT3-dependent mechanism

Seki, N., Kan-o, K., Matsumoto, K., Fukuyama, S., Hamano, S., Tonai, K., ota, K., Inoue, H. & Nakanishi, Y., Dec 9 2017, In : Biochemical and Biophysical Research Communications. 494, 1-2, p. 242-248 7 p.

Research output: Contribution to journalArticle

Double-Stranded RNA
Up-Regulation
Epithelial Cells
Poly C
Viruses
1 Citation (Scopus)

Lingual alveolar soft part sarcoma responsive to pazopanib: A case report

Yoshihiro, T., Tsuchihashi, K., Nio, K., Arita, S., Nakano, T., Yasumatsu, R., Jiroumaru, R., ariyama, H., Kusaba, H., Oda, Y., Akashi, K. & Baba, E., Nov 1 2017, In : Medicine (United States). 96, 44, e8470.

Research output: Contribution to journalArticle

Alveolar Soft Part Sarcoma
Tongue
Articulation Disorders
Lung
Ifosfamide

Metastatic esophageal cancer presenting as shock by injury of vagus nerve mimicking baroreceptor reflex: A case report

Tsuchihashi, K., Yoshihiro, T., Aikawa, T., Nio, K., Takayoshi, K., Yokoyama, T., Fukata, M., Arita, S., ariyama, H., Shimizu, Y., Yoshida, Y., torisu, T., Esaki, M., Odashiro, K., Kusaba, H., Akashi, K. & Baba, E., Dec 1 2017, In : Medicine (United States). 96, 49, e8987.

Research output: Contribution to journalArticle

Vagus Nerve Injuries
Baroreflex
Esophageal Neoplasms
Vagus Nerve
Shock
15 Citations (Scopus)

Monitoring of somatic mutations in circulating cell-free DNA by digital PCR and next-generation sequencing during afatinib treatment in patients with lung adenocarcinoma positive for EGFR activating mutations

Iwama, E., Sakai, K., Azuma, K., Harada, T., Harada, D., Nosaki, K., Hotta, K., Ohyanagi, F., Kurata, T., Fukuhara, T., Akamatsu, H., Goto, K., Shimose, T., Kishimoto, J., Nakanishi, Y., Nishio, K. & Okamoto, I., Jan 1 2017, In : Annals of Oncology. 28, 1, p. 136-141 6 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Polymerase Chain Reaction
Mutation
DNA
Alleles
12 Citations (Scopus)

Most T790M mutations are present on the same EGFR allele as activating mutations in patients with non–small cell lung cancer

Hidaka, N., Iwama, E., Kubo, N., Harada, T., Miyawaki, K., Tanaka, K., Okamoto, I., Baba, E., Akashi, K., Sasaki, H. & Nakanishi, Y., Jun 1 2017, In : Lung Cancer. 108, p. 75-82 8 p.

Research output: Contribution to journalArticle

erbB-1 Genes
Non-Small Cell Lung Carcinoma
Alleles
Mutation
Protein-Tyrosine Kinases

Regorafenib-induced retinal and gastrointestinal hemorrhage in a metastatic colorectal cancer patient with liver dysfunction

Tsuchihashi, K., Shimokawa, H., Takayoshi, K., Nio, K., Aikawa, T., Matsushita, Y., Wada, I., Arita, S., ariyama, H., Kusaba, H., Sonoda, K., Akashi, K. & Baba, E., Oct 1 2017, In : Medicine (United States). 96, 42, e8285.

Research output: Contribution to journalArticle

Retinal Hemorrhage
Gastrointestinal Hemorrhage
Liver Diseases
Colorectal Neoplasms
Hemorrhage
5 Citations (Scopus)

Suggestion of added value by bevacizumab to chemotherapy in patients with unresectable or recurrent small bowel cancer

Takayoshi, K., Kusaba, H., Uenomachi, M., Mitsugi, K., Makiyama, C., Makiyama, A., Uchino, K., Shirakawa, T., Shibata, Y., Shinohara, Y., Inadomi, K., Tsuchihashi, K., Arita, S., ariyama, H., Esaki, T., Akashi, K. & Baba, E., Aug 1 2017, In : Cancer Chemotherapy and Pharmacology. 80, 2, p. 333-342 10 p.

Research output: Contribution to journalArticle

Intestinal Neoplasms
Chemotherapy
Drug Therapy
Adenocarcinoma
oxaliplatin

Systemic chemotherapy with pronounced efficacy and neutropenia in a granulocyte-colony stimulating factor-producingadvanced gastric neuroendocrine carcinoma

Tsuruta, N., Takayoshi, K., Arita, S., Aikawa, T., ariyama, H., Kusaba, H., Ouchida, K., Nagai, E., Kouhashi, K., Hirahashi, M., Inadomi, K., Tanaka, M., Sagara, K., Okumura, Y., Nio, K., Nakano, M., Nakamura, M., Oda, Y., Akashi, K. & Baba, E., Jan 1 2017, In : Oncology Letters. 14, 2, p. 1500-1504 5 p.

Research output: Contribution to journalArticle

Neuroendocrine Carcinoma
Granulocyte Colony-Stimulating Factor
Neutropenia
Stomach
Drug Therapy
1 Citation (Scopus)
2016
11 Citations (Scopus)

Bi-cytopenia possibly induced by anti-PD-1 antibody for primary malignant melanoma of the esophagus A case report

Inadomi, K., Kumagai, H., Arita, S., Tsuruta, N., Takayoshi, K., Mishima, K., Ota, S. I., Tanaka, M., Okumura, Y., Sagara, K., Nio, K., Nakano, M., Hiroshi, U., Yamamoto, H., ariyama, H., Kusaba, H., Niiro, H., Oda, Y., Akashi, K. & Baba, E., Jul 26 2016, In : Medicine (United States). 95, 29, e4283.

Research output: Contribution to journalArticle

Esophagus
Melanoma
Antibodies
Neoplasm Metastasis
Liver
5 Citations (Scopus)

Characteristics of smoking patients with lung cancer with emphysematous bullae

Iwama, E., Okamoto, I., Yabuuchi, H., Takayama, K., Harada, T., Matsuo, Y., Tokunaga, S., Baba, E. & Nakanishi, Y., Jan 1 2016, In : Journal of Thoracic Oncology. 11, 9, p. 1586-1590 5 p.

Research output: Contribution to journalArticle

Blister
Lung Neoplasms
Smoking
Emphysema
Epidermal Growth Factor
2 Citations (Scopus)

Clinicopathological evaluation of pre-operative chemoradiotherapy with S-1 as a treatment for locally advanced oral squamous cell carcinoma

Kawano, S., Zheng, Y., Oobu, K., Matsubara, R., Goto, Y., Chikui, T., Yoshitake, T., Kiyoshima, T., Jinno, T., Maruse, Y., Mitate, E., kitamura, R., Tanaka, H., Toyoshima, T., Sugiura, T. & Nakamura, S., May 1 2016, In : Oncology Letters. 11, 5, p. 3369-3376 8 p.

Research output: Contribution to journalArticle

Chemoradiotherapy
Squamous Cell Carcinoma
Therapeutics
Radiotherapy
Survival Rate