Department of Advanced Medical Initiatives

Research output

Research output per year 1984 2009 2010 2011 2012 2013 2014 2015 2016 2017 2022

• 715 Article
• 80 Conference contribution
• 53 Review article
• 12 Conference article
• 39 More
  • 12 Letter
  • 7 Comment/debate
  • 6 Chapter
  • 6 Editorial
  • 5 Paper
  • 3 Short survey

Research output per year

Research output per year

Search results

• 2022

  Clinical Challenges in Diagnosis, Tumor Localization and Treatment of Tumor-Induced Osteomalacia: Outcome of a Retrospective Surveillance

  Hidaka, N., Koga, M., Kimura, S., Hoshino, Y., Kato, H., Kinoshita, Y., Makita, N., Nangaku, M., Horiguchi, K., Furukawa, Y., Ohnaka, K., Inagaki, K., Nakagawa, A., Suzuki, A., Takeuchi, Y., Fukumoto, S., Nakatani, F. & Ito, N., 2022, (Accepted/In press) In: Journal of Bone and Mineral Research.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Patient 100%
  • Osteomalacia 63%
  • Neoplasm 54%
  • Bone 27%
  • Positron Emission Tomography-Computed Tomography 27%
  4 Citations (Scopus)

• Contribution of pre-existing neoantigen-specific T cells to a durable complete response after tumor-pulsed dendritic cell vaccine plus nivolumab therapy in a patient with metastatic salivary duct carcinoma

  Ichimiya, S., Fujimura, A., Masuda, M., Masuda, S., Yasumatsu, R., Umebayashi, M., Tanaka, H., Koya, N., Nakagawa, S., Yew, P. Y., Yoshimura, S., Onishi, H., Nakamura, M., Nakamura, Y. & Morisaki, T., 2022, In: Immunological Investigations. 51, 5, p. 1498-1514 17 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Neoantigen 100%
  • Dendritic Cell Vaccine 57%
  • Cells 28%
  • Immunity 28%
  • Cell Lysate 28%
  2 Citations (Scopus)

• ERAP2 is a novel target involved in autophagy and activation of pancreatic stellate cells via UPR signaling pathway

  Guan, W., Nakata, K., Sagara, A., Iwamoto, C., Endo, S., Matsuda, R., Matsumoto, S., Ikenaga, N., Shindo, K., Moriyama, T., Onishi, H., Ohuchida, K., Oda, Y. & Nakamura, M., Jan 2022, In: Pancreatology. 22, 1, p. 9-19 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Pancreatic Stellate Cell 100%
  • Autophagy 80%
  • Endoplasmic reticulum 60%
  • Aminopeptidase 60%
  • Pancreas Adenocarcinoma 50%
  2 Citations (Scopus)

• Impact of Antithrombin Activity Levels Following Recombinant Antithrombin Gamma Therapy in Patients with Sepsis-Induced Disseminated Intravascular Coagulation

  Akahoshi, T., Kaku, N., Shono, Y., Yamamoto, Y., Takahashi, K., Iyonaga, T., Momii, K., Nishihara, M., Maki, J., Tokuda, K. & Yamaura, K., 2022, In: Clinical and Applied Thrombosis/Hemostasis. 28

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Disseminated Intravascular Clotting 100%
  • Patient 50%
  • Recombinant Antithrombin III 50%
  • Dose 33%
  • Inpatient 33%
  1 Citation (Scopus)

• Maxillofacial injury caused by bamboo skewer penetrating the cranial cavity

  Kondo, T., Kaku, N., Hanaki, Y., Tsuchihashi, N. & Akahoshi, T., Jan 1 2022, In: Pediatrics International. 64, 1, p. e15018

  Research output: Contribution to journal › Article › peer-review

• Potential therapeutic targets discovery by transcriptome analysis of an in vitro human gastric signet ring carcinoma model

  Yamaguchi, K., Yoshihiro, T., Ariyama, H., Ito, M., Nakano, M., Semba, Y., Nogami, J., Tsuchihashi, K., Yamauchi, T., Ueno, S., Isobe, T., Shindo, K., Moriyama, T., Ohuchida, K., Nakamura, M., Nagao, Y., Ikeda, T., Hashizume, M., Konomi, H., Torisu, T., & 8 othersKitazono, T., Kanayama, T., Tomita, H., Oda, Y., Kusaba, H., Maeda, T., Akashi, K. & Baba, E., Jun 4 2022, (E-pub ahead of print) In: Gastric Cancer.

  Research output: Contribution to journal › Article › peer-review

  • Signet Ring Cell Carcinoma 100%
  • Uvomorulin 77%
  • Organoid 55%
  • Cells 44%
  • Combination Therapy 33%
  2 Citations (Scopus)

• Prediction of intracranial lesions in patients with consciousness disturbance by ultrasonography in the intensive care unit

  Shono, Y., Mezuki, S., Akahoshi, T., Nishihara, M., Kaku, N., Maki, J., Tokuda, K. & Kitazono, T., Sept 2022, In: Journal of International Medical Research. 50, 9

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Patient 100%
  • Lesion 100%
  • Echography 80%
  • Intensive Care Unit 80%
  • Inpatient 60%

• PTPN3 Could Be a Therapeutic Target of Pancreatic Cancer

  Ohnishi, H., Iwamoto, N., Sakanashi, K., Koga, S., Oyama, Y., Yanai, K., Nakamura, K., Nagai, S., Fujimura, A., Nakayama, K., Ozono, K. & Yamasaki, A., Jun 2022, In: Anticancer research. 42, 6, p. 2869-2874 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Non Receptor Protein Tyrosine Phosphatase 3 100%
  • Protein Tyrosine Phosphatase 100%
  • Pancreas Cancer 50%
  • Combination Therapy 37%
  • Western Blot 37%

• Radiation Emergency Medical Preparedness in Japan: A Survey of Nuclear Emergency Core Hospitals

  Nagata, T., Arishima, T., Yamaguchi, Y., Hirohashi, N., Usa, T., Hasegawa, A., Hanada, H., Yamamoto, N., Okamoto, T., Akahoshi, T., Hamada, M., Abe, T., Kikukawa, M., Nakao, H., Yamamura, H., Sakamoto, T., Akashi, M. & Hagihara, A., 2022, (Accepted/In press) In: Disaster Medicine and Public Health Preparedness.

  Research output: Contribution to journal › Article › peer-review

  • Radiation 100%
  • Hospitals 75%
  • Disasters 75%
  • Emergency 75%
  • Hospital 75%
  1 Citation (Scopus)

• Tropomyosin-related Kinase B Is Potentially a Biomarker of Prognosis and Therapeutic Target for Malignant Thymic Epithelial Tumors

  Ozono, K., Onishi, H., Iwamoto, N., Nakamura, K., Miyoshi, K., Nakamura, M. & Oda, Y., Aug 2022, In: Anticancer research. 42, 8, p. 3779-3787 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Phosphotransferase 100%
  • Epithelium Tumor 100%
  • Receptor 87%
  • Brain Derived Neurotrophic Factor 50%
  • Prognosis 37%
• 2021

  Development of 20 cm sample bore size dynamic nuclear polarization (DNP)-MRI at 16 mT and redox metabolic imaging of acute hepatitis rat model

  Eto, H., Naganuma, T., Nakao, M., Murata, M., Elhelaly, A. E., Noda, Y., Kato, H., Matsuo, M., Akahoshi, T., Hashizume, M. & Hyodo, F., Jun 2021, In: Free Radical Biology and Medicine. 169, p. 149-157 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Magnetic Resonance Imaging 100%
  • Dynamic Nuclear Polarization 100%
  • Redox Metabolism 44%
  • Dynamics 33%
  • Sample 22%

• Efficacy of thromboelastography in the management of anticoagulation for veno-venous extracorporeal membrane oxygenation in a coronavirus disease 2019 patient

  Nakashima, R., Nishihara, M., Iyonaga, T., Iwasaka, S., Yamamoto, Y., Shono, Y., Maki, J., Tokuda, K., Akahoshi, T., Higo, T., Kitazono, T. & Tsutsui, H., Apr 2 2021, In: Medicine (United States). 100, 23, e26313.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Extracorporeal Membrane Oxygenation 100%
  • Heparin 85%
  • Patient 71%
  • COVID-19 71%
  • Marker 42%
  2 Citations (Scopus)

• Establishment and characterization of a primary cell culture derived from external auditory canal squamous cell carcinoma

  Sekino, Y., Imaizumi, A., Komune, N., Ono, M., Sato, K., Masuda, S., Fujimura, A., Koike, K., Hongo, T., Uchi, R., Onishi, H. & Nakagawa, T., Aug 2021, In: FEBS Open Bio. 11, 8, p. 2211-2224 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cells 100%
  • Squamous Cell Carcinoma 100%
  • Cell Culture 100%
  • External Auditory Canal 100%
  • Feeder Cell 100%
  3 Citations (Scopus)

• GLI2 but not GLI1/GLI3 plays a central role in the induction of malignant phenotype of gallbladder cancer

  Ichimiya, S., Onishi, H., Nagao, S., Koga, S., Sakihama, K., Nakayama, K., Fujimura, A., Oyama, Y., Imaizumi, A., Oda, Y. & Nakamura, M., Mar 2021, In: Oncology reports. 45, 3, p. 997-1010 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • GLI2 100%
  • Gallbladder 100%
  • Gallbladder Cancer 100%
  • GLI1 66%
  • GLI3 66%
  1 Citation (Scopus)

• Histidine-Rich Glycoprotein Alleviates Liver Ischemia/Reperfusion Injury in Mice With Nonalcoholic Steatohepatitis

  Guo, J., Akahoshi, T., Mizuta, Y., Murata, M., Narahara, S., Kawano, T., Nagao, Y., Zhang, S., Tomikawa, M., Kawanaka, H. & Hashizume, M., Jun 2021, In: Liver Transplantation. 27, 6, p. 840-853 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Glycoprotein 100%
  • Histidine 100%
  • Reperfusion Injury 53%
  • Nonalcoholic Fatty Liver 46%
  • Diet 38%
  6 Citations (Scopus)

• PTPN3 is a potential target for a new cancer immunotherapy that has a dual effect of T cell activation and direct cancer inhibition in lung neuroendocrine tumor

  Koga, S., Onishi, H., Masuda, S., Fujimura, A., Ichimiya, S., Nakayama, K., Imaizumi, A., Nishiyama, K., Kojima, M., Miyoshi, K., Nakamura, K., Umebayashi, M., Morisaki, T. & Nakamura, M., Sept 2021, In: Translational Oncology. 14, 9, 101152.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Protein Tyrosine Phosphatase 100%
  • Lung 50%
  • Lymphocyte 31%
  • Cancer Cell 25%
  • Small Cell Lung Cancer 25%
  8 Citations (Scopus)

• Reflectance spectra analysis for mucous assessment

  Chiba, T., Murata, M., Kawano, T., Hashizume, M. & Akahoshi, T., 2021, In: World Journal of Gastrointestinal Oncology. 13, 8, p. 822-834 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Diagnosis 100%
  • Tissues 66%
  • Analysis 66%
  • Development 33%
  • Malignant Neoplasm 33%

• The effect of real-time monitoring of physical activity intensity in diabetic patients

  Tanaka, R., Fujita, K., Maeno, S., Yakushiji, K., Tanaka, S., Ohnaka, K., Ashida, K., Sakamoto, S. & Nomura, M., 2021, (Accepted/In press) In: Japan Journal of Nursing Science.

  Research output: Contribution to journal › Article › peer-review

  • Control 100%
  • Hemoglobin A1c 75%
  • Diabetes Mellitus 75%
  • Patient 75%
  • Time 50%

• Trkb/bdnf signaling could be a new therapeutic target for pancreatic cancer

  OYAMA, YASUHIRO., NAGAO, SHINJIRO., NA, LIN., YANAI, KOSUKE., UMEBAYASHI, MASAYO., NAKAMURA, KATSUYA., Nagai, S., FUJIMURA, AKIKO., YAMASAKI, AKIO., NAKAYAMA, KAZUNORI., MORISAKI, TAKASHI. & ONISHI, HIDEYA., Aug 2021, In: Anticancer research. 41, 8, p. 4047-4052 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Phosphotransferase 100%
  • Tropomyosin 100%
  • Kinase 100%
  • Brain Derived Neurotrophic Factor 80%
  • Brain-Derived Neurotrophic Factor 80%
  6 Citations (Scopus)
• 2020

  Alteration in faecal bile acids, gut microbial composition and diversity after laparoscopic sleeve gastrectomy

  Ikeda, T., Aida, M., Yoshida, Y., Matsumoto, S., Tanaka, M., Nakayama, J., Nagao, Y., Nakata, R., Oki, E., Akahoshi, T., Okano, S., Nomura, M., Hashizume, M. & Maehara, Y., Nov 1 2020, In: British Journal of Surgery. 107, 12, p. 1673-1685 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Laparoscopic Sleeve Gastrectomy 100%
  • Bile Acid 71%
  • Bile 71%
  • Feces 57%
  • Cells 42%
  15 Citations (Scopus)

• Clinical improvement in a patient with severe coronavirus disease 2019 after administration of hydroxychloroquine and continuous hemodiafiltlation with nafamostat mesylate

  Iwasaka, S., Shono, Y., Tokuda, K., Nakashima, K., Yamamoto, Y., Maki, J., Nagasaki, Y., Shimono, N., Akahoshi, T. & Taguchi, T., Dec 2020, In: Journal of Infection and Chemotherapy. 26, 12, p. 1319-1323 5 p.

  Research output: Contribution to journal › Article › peer-review

  • COVID-19 100%
  • Clinical Study 33%
  • Nafamstat Mesilate 33%
  • Patient 25%
  • Therapeutic Procedure 25%
  7 Citations (Scopus)

• Development of a novel molecular probe for the detection of liver mitochondrial redox metabolism

  Hosain, M. Z., Hyodo, F., Mori, T., Takahashi, K., Nagao, Y., Eto, H., Murata, M., Akahoshi, T., Matsuo, M. & Katayama, Y., Dec 1 2020, In: Scientific reports. 10, 1, 16489.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Probe 100%
  • Molecular Probe 25%
  • Mitochondrion 25%
  • Oxidative Stress 16%
  • Development 16%

• Exosomes from adipose tissue-derived mesenchymal stem cells ameliorate histone-induced acute lung injury by activating the PI3K/Akt pathway in endothelial cells

  Mizuta, Y., Akahoshi, T., Guo, J., Zhang, S., Narahara, S., Kawano, T., Murata, M., Tokuda, K., Eto, M., Hashizume, M. & Yamaura, K., Dec 2020, In: Stem Cell Research and Therapy. 11, 1, 508.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Stem Cell 100%
  • Adipose-Derived Mesenchymal Stem Cell 85%
  • Histone 71%
  • Exosome 28%
  • Phosphorylation 21%
  27 Citations (Scopus)

• FAM115C could be a novel tumor suppressor associated with prolonged survival in pancreatic cancer patients

  Saeki, K., Onishi, H., Koga, S., Ichimiya, S., Nakayama, K., Oyama, Y., Kawamoto, M., Sakihama, K., Yamamoto, T., Matsuda, R., Miyasaka, Y., Nakamura, M. & Oda, Y., 2020, In: Journal of Cancer. 11, 8, p. 2289-2302 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Pancreas Adenocarcinoma 100%
  • Tumor Suppressor Protein 44%
  • Hypoxia 33%
  • Cells 22%
  • Gene 22%
  5 Citations (Scopus)

• Intranodal Administration of Neoantigen Peptide-loaded Dendritic Cell Vaccine Elicits Epitope-specific T Cell Responses and Clinical Effects in a Patient with Chemorefractory Ovarian Cancer with Malignant Ascites

  Morisaki, T., Hikichi, T., Onishi, H., Morisaki, T., Kubo, M., Hirano, T., Yoshimura, S., Kiyotani, K. & Nakamura, Y., 2020, In: Immunological Investigations. p. 1-18 18 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Neoantigen 100%
  • Immunotherapy 25%
  • Lymphocyte 25%
  • T Cell Receptor 12%
  • Mutant 12%
  18 Citations (Scopus)

• NFκB and TGFβ contribute to the expression of PTPN3 in activated human lymphocytes

  Nakayama, K., Onishi, H., Fujimura, A., Imaizumi, A., Kawamoto, M., Oyama, Y., Ichimiya, S., Koga, S., Fujimoto, Y., Nakashima, K. & Nakamura, M., Dec 2020, In: Cellular Immunology. 358, 104237.

  Research output: Contribution to journal › Article › peer-review

  • Lymphocyte 100%
  • Non Receptor Protein Tyrosine Phosphatase 3 57%
  • Immunity 14%
  • Immunotherapy 14%
  • Biological Activity 7%
  2 Citations (Scopus)

• Patched 1-interacting peptide represses fibrosis in pancreatic cancer to augment the effectiveness of immunotherapy

  Oyama, Y., Onishi, H., Koga, S., Murahashi, M., Ichimiya, S., Nakayama, K., Fujimura, A., Kawamoto, M., Imaizumi, A., Umebayashi, M., Ohuchida, K., Morisaki, T. & Nakamura, M., May 1 2020, In: Journal of Immunotherapy. 43, 4, p. 121-133 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Peptide 100%
  • Pancreas Adenocarcinoma 75%
  • Malignant Neoplasm 62%
  • Fibrosis 62%
  • Immunocompetent Cell 50%
  14 Citations (Scopus)

• Prognostic factors for the short-term mortality of patients with rheumatoid arthritis admitted to intensive care units

  Fujiwara, T., Tokuda, K., Momii, K., Shiomoto, K., Tsushima, H., Akasaki, Y., Ikemura, S., Fukushi, J. I., Maki, J., Kaku, N., Akahoshi, T., Taguchi, T. & Nakashima, Y., Dec 2020, In: BMC Rheumatology. 4, 1, 64.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Patient 100%
  • Intensive Care Unit 83%
  • Rheumatoid Arthritis 50%
  • Inflammatory Arthritis 50%
  • Mortality 41%
  3 Citations (Scopus)

• Self-Propelled Colonoscopy Robot Using Flexible Paddles

  Osawa, K., Nakadate, R., Arata, J., Nagao, Y., Akahoshi, T., Eto, M. & Hashizume, M., Oct 2020, In: IEEE Robotics and Automation Letters. 5, 4, p. 6710-6716 7 p., 9170783.

  Research output: Contribution to journal › Article › peer-review

  • Robotics 100%
  • Robot 83%
  • Force 50%
  • Self Concept 50%
  • Colon 50%
  7 Citations (Scopus)

• Sodium thiosulfate prevents doxorubicin-induced DNA damage and apoptosis in cardiomyocytes in mice

  Mizuta, Y., Tokuda, K., Guo, J., Zhang, S., Narahara, S., Kawano, T., Murata, M., Yamaura, K., Hoka, S., Hashizume, M. & Akahoshi, T., Jul 13 2020, (E-pub ahead of print) In: Life Sciences. 257, p. 118074

  Research output: Contribution to journal › Article › peer-review

  • Doxorubicin 100%
  • Sodium Thiosulfate 61%
  • Apoptosis 19%
  • DNA 14%
  • Antioxidant 14%
  16 Citations (Scopus)

• Surgical Navigation Improves Renal Parenchyma Volume Preservation in Robot-Assisted Partial Nephrectomy: A Propensity Score Matched Comparative Analysis

  Kobayashi, S., Cho, B., Mutaguchi, J., Inokuchi, J., Tatsugami, K., Hashizume, M. & Eto, M., Jul 1 2020, In: The Journal of urology. 204, 1, p. 149-156 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Parenchyma 100%
  • Partial Nephrectomy 80%
  • Patient 40%
  • Analysis 40%
  • Neoplasm 20%
  6 Citations (Scopus)

• The farnesyltransferase inhibitor tipifarnib protects against autoimmune hepatitis induced by Concanavalin A

  Guo, J., Shirozu, K., Akahoshi, T., Mizuta, Y., Murata, M. & Yamaura, K., Jun 2020, In: International Immunopharmacology. 83, 106462.

  Research output: Contribution to journal › Article › peer-review

  • Concanavalin A 100%
  • Tipifarnib 100%
  • Autoimmune Hepatitis 36%
  • T Cell 36%
  • CD4 36%
  1 Citation (Scopus)
• 2019

  A case of acute exacerbation of chronic adrenal insufficiency due to ipilimumab treatment for advanced melanoma

  Sakaguchi, C., Yano, S., Ashida, K., Wada, N., Ohe, K., Nagata, H., Matsuda, Y., Sakamoto, S., Sakamoto, R., Ohnaka, K., Uchi, H., Furue, M., Nomura, M. & Ogawa, Y., 2019, In: American Journal of Case Reports. 20, p. 106-110 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Therapeutic Procedure 100%
  • Ipilimumab 88%
  • Adrenal Insufficiency 55%
  • Case Report 44%
  • Nivolumab 44%
  6 Citations (Scopus)

• Colorectal endoscopic submucosal dissection using novel articulating devices: a comparative study in a live porcine model

  Okamoto, Y., Nakadate, R., Nakamura, S., Arata, J., Oguri, S., Moriyama, T., Esaki, M., Iwasa, T., Ohuchida, K., Akahoshi, T., Ikeda, T., Kitazono, T. & Hashizume, M., Feb 15 2019, In: Surgical endoscopy. 33, 2, p. 651-657 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Endoscopic Submucosal Dissection 100%
  • Perforation 60%
  • Adverse Event 40%
  • Specimen 20%
  • Colon 20%
  6 Citations (Scopus)

• Endoscopic surgery in Japan: The 13th national survey (2014-2015) by the Japan Society for Endoscopic Surgery

  Shiroshita, H., Inomata, M., Bandoh, T., Uchida, H., Akira, S., Hashizume, M., Yamaguchi, S., Eguchi, S., Wada, N., Takiguchi, S., Ieiri, S., Endo, S., Iwazaki, M., Tamaki, Y., Tabata, M., Kanayama, H., Mimata, H., Hasegawa, T., Onishi, K., Yanaga, K., & 6 othersMorikawa, T., Terachi, T., Matsumoto, S., Yamashita, Y., Kitano, S. & Watanabe, M., Jan 1 2019, In: Asian journal of endoscopic surgery. 12, 1, p. 7-18 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Endoscopic Surgery 100%
  • Development 18%
  • Patient 9%
  • Cardiovascular System 9%
  • Surgery 9%
  24 Citations (Scopus)

• Genome-wide association study revealed novel loci which aggravate asymptomatic hyperuricaemia into gout

  Kawamura, Y., Nakaoka, H., Nakayama, A., Okada, Y., Yamamoto, K., Higashino, T., Sakiyama, M., Shimizu, T., Ooyama, H., Ooyama, K., Nagase, M., Hidaka, Y., Shirahama, Y., Hosomichi, K., Nishida, Y., Shimoshikiryo, I., Hishida, A., Katsuura-Kamano, S., Shimizu, S., Kawaguchi, M., & 29 othersUemura, H., Ibusuki, R., Hara, M., Naito, M., Takao, M., Nakajima, M., Iwasawa, S., Nakashima, H., Ohnaka, K., Nakamura, T., Stiburkova, B., Merriman, T. R., Nakatochi, M., Ichihara, S., Yokota, M., Takada, T., Saitoh, T., Kamatani, Y., Takahashi, A., Arisawa, K., Takezaki, T., Tanaka, K., Wakai, K., Kubo, M., Hosoya, T., Ichida, K., Inoue, I., Shinomiya, N. & Matsuo, H., Oct 1 2019, In: Annals of the Rheumatic Diseases. 78, 10, p. 1430-1437 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Gout 100%
  • Hyperuricemia 52%
  • Genome Wide Association Study 47%
  • Genome-Wide Association Study 47%
  • Development 17%
  55 Citations (Scopus)

• Japanese periodical nationwide epidemiologic survey of aberrant portal hemodynamics

  Ohfuji, S., Furuichi, Y., Akahoshi, T., Kage, M., Obara, K., Hashizume, M., Matsuura, T., Fukushima, W. & Nakamura, Y., Aug 1 2019, In: Hepatology Research. 49, 8, p. 890-901 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Obstruction 100%
  • Portal Hypertension 100%
  • Syndrome 85%
  • Patient 57%
  • Cohort Effect 28%
  3 Citations (Scopus)

• Liprin-α4 as a new therapeutic target for SCLC as an upstream mediator of HIF1α

  Onishi, H., Yamasaki, A., Nakamura, K., Ichimiya, S., Yanai, K., Umebayashi, M., Nagai, S. & Morisaki, T., Mar 1 2019, In: Anticancer research. 39, 3, p. 1179-1184 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Small Cell Lung Cancer 100%
  • Hypoxia 100%
  • Cells 60%
  • Chemosensitivity 60%
  • Combination Therapy 40%
  8 Citations (Scopus)

• Pancreatic Juice Exosomal MicroRNAs as Biomarkers for Detection of Pancreatic Ductal Adenocarcinoma

  Nakamura, S., Sadakari, Y., Takao, O., Okayama, T., Nakashima, Y., Gotoh, Y., Saeki, K., Mori, Y., Nakata, K., Miyasaka, Y., Onishi, H., Oda, Y., Goggins, M. & Nakamura, M., Jul 15 2019, In: Annals of Surgical Oncology. 26, 7, p. 2104-2111 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Pancreas Adenocarcinoma 100%
  • Pancreatic Juice 90%
  • Patient 80%
  • Chronic Pancreatitis 60%
  • microRNA 155 60%
  48 Citations (Scopus)

• PTPN3 expressed in activated T lymphocytes is a candidate for a non-antibody-type immune checkpoint inhibitor

  Fujimura, A., Nakayama, K., Imaizumi, A., Kawamoto, M., Oyama, Y., Ichimiya, S., Umebayashi, M., Koya, N., Morisaki, T., Nakagawa, T. & Onishi, H., Oct 1 2019, In: Cancer Immunology, Immunotherapy. 68, 10, p. 1649-1660 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Lymphocyte 100%
  • Immunity 40%
  • Neoplasm 20%
  • T Cell 20%
  • Antibody 20%
  7 Citations (Scopus)

• The evolution of surgical treatment for gastrointestinal cancers

  Maehara, Y., Soejima, Y., Yoshizumi, T., Kawahara, N., Oki, E., Saeki, H., Akahoshi, T., Ikegami, T., Yamashita, Y. I., Furuyama, T., Sugimachi, K., Harada, N., Tagawa, T., Harimoto, N., Itoh, S., Sonoda, H., Andou, K., Nakashima, Y., Nagao, Y., Yamashita, N., & 17 othersKasagi, Y., Yukaya, T., Kurihara, T., Tsutsumi, R., Takamori, S., Sasaki, S., Ikeda, T., Yonemitsu, Y., Fukuhara, T., Kitao, H., Iimori, M., Kataoka, Y., Wakasa, T., Suzuki, M., Teraishi, K., Yoshida, Y. & Mori, M., Nov 1 2019, In: International Journal of Clinical Oncology. 24, 11, p. 1333-1349 17 p.

  Research output: Contribution to journal › Article › peer-review

  • Malignant Neoplasm 100%
  • Tissues 100%
  • Gastrointestinal Cancer 75%
  • Development 50%
  • Chromosomal Instability 50%
  5 Citations (Scopus)
• 2018

  A new robotic-assisted flexible endoscope with single-hand control: endoscopic submucosal dissection in the ex vivo porcine stomach

  iwasa, T., Nakadate, R., Onogi, S., Okamoto, Y., Arata, J., Oguri, S., Ogino, H., Ihara, E., Ohuchida, K., Akahoshi, T., Ikeda, T., Ogawa, Y. & Hashizume, M., Jul 1 2018, In: Surgical endoscopy. 32, 7, p. 3386-3392 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Endoscope 100%
  • Endoscopic Submucosal Dissection 35%
  • Surgery 20%
  • Movement (Physiology) 15%
  • Ex Vivo 10%
  27 Citations (Scopus)

• A novel histological examination with dynamic three-dimensional reconstruction from multiple immunohistochemically stained sections of a PD-L1-positive colon cancer

  Korehisa, S., Ikeda, T., Okano, S., Saeki, H., Oki, E., Oda, Y., Hashizume, M. & Maehara, Y., Mar 2018, In: Histopathology. 72, 4, p. 697-703 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Programmed Cell Death 100%
  • Ligand 100%
  • Cells 60%
  • Colon Cancer 60%
  • Microsatellite Instability 40%
  11 Citations (Scopus)

• Antithrombin III for portal vein thrombosis in patients with liver disease: A randomized, double-blind, controlled trial

  The NPB-06 study group, Feb 2018, In: Hepatology Research. 48, 3, p. E107-E116

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Patient 100%
  • Antithrombin III 72%
  • Portal Vein Thrombosis 45%
  • Liver Disease 27%
  • Coagulation 27%
  29 Citations (Scopus)

• Catumaxomab with activated T-cells efficiently lyses chemoresistant EpCAM-positive triple-negative breast cancer cell lines

  Kubo, M., Umebayashi, M., Kurata, K., Mori, H., Kai, M., Onishi, H., Katano, M., Nakamura, M. & Morisaki, T., Jul 2018, In: Anticancer research. 38, 7, p. 4273-4279 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Epithelial Cell Adhesion Molecule 100%
  • T Cell 71%
  • Triple Negative Breast Cancer 71%
  • Cancer Cell 57%
  • Catumaxomab 57%
  16 Citations (Scopus)

• Combined gemcitabine and metronidazole is a promising therapeutic strategy for cancer stem-like cholangiocarcinoma

  Kawamoto, M., Umebayashi, M., Tanaka, H., Koya, N., Nakagawa, S., Kawabe, K., Onishi, H., Nakamura, M. & Morisaki, T., May 2018, In: Anticancer research. 38, 5, p. 2739-2748 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Metronidazole 100%
  • Gemcitabine 66%
  • Cholangiocarcinoma 55%
  • Bile Duct Carcinoma 55%
  • Malignant Neoplasm 44%
  12 Citations (Scopus)

• Customization of laparoscopic gastric devascularization and splenectomy for gastric varices based on CT vascular anatomy

  Kawanaka, H., Akahoshi, T., Nagao, Y., Kinjo, N., Yoshida, D., Matsumoto, Y., Harimoto, N., Itoh, S., Yoshizumi, T. & Maehara, Y., Jan 1 2018, In: Surgical endoscopy. 32, 1, p. 114-126 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Splenectomy 100%
  • Devascularization 100%
  • Patient 75%
  • Stomach Varices 75%
  • Vein 50%
  4 Citations (Scopus)

• Dispatcher-assisted bystander cardiopulmonary resuscitation and survival in out-of-hospital cardiac arrest

  Hagihara, A., Onozuka, D., Shibuta, H., Hasegawa, M. & Nagata, T., Apr 19 2018, (E-pub ahead of print) In: International Journal of Cardiology.

  Research output: Contribution to journal › Article › peer-review

  • Resuscitation 100%
  • Survival 77%
  • Out of Hospital Cardiac Arrest 66%
  • Patient 44%
  • Odds Ratio 44%
  13 Citations (Scopus)

• Effect of early treatment on physical function in daily management of rheumatoid arthritis: A 5-year longitudinal study of rheumatoid arthritis patients in the national database of rheumatic diseases in Japan

  Hirata, A., Suenaga, Y., Miyamura, T., Matsui, T., Tohma, S., Suematsu, E., Ohnaka, K. & Takayanagi, R., 2018, In: International Journal of Rheumatic Diseases. 21, 4, p. 828-835 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Patient 100%
  • Rheumatoid Arthritis 58%
  • Biological Product 50%
  • Health Assessment Questionnaire 41%
  • Methotrexate 33%
  4 Citations (Scopus)

• Feasibility of an AI-Based Measure of the Hand Motions of Expert and Novice Surgeons

  Uemura, M., Tomikawa, M., Miao, T., Souzaki, R., Ieiri, S., Akahoshi, T., Lefor, A. K. & Hashizume, M., 2018, In: Computational and Mathematical Methods in Medicine. 2018, 9873273.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Surgeon 100%
  • Skill 50%
  • Decision Making 25%
  • Intelligence 25%
  • Assessment 12%
  23 Citations (Scopus)