Department of Advanced Medical Initiatives

Research Output 1980 2019

2019

A case of acute exacerbation of chronic adrenal insufficiency due to ipilimumab treatment for advanced melanoma

Sakaguchi, C., Yano, S., Ashida, K., Wada, N., Ohe, K., Nagata, H., matsuda, Y., Sakamoto, S., Sakamoto, R., Keizo, O., Hiroshi, U., Furue, M., Nomura, M. & Ogawa, Y., Jan 1 2019, In : American Journal of Case Reports. 20, p. 106-110 5 p.

Research output: Contribution to journalArticle

Adrenal Insufficiency
Melanoma
Therapeutics
Programmed Cell Death 1 Receptor
ipilimumab
Open Access
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Diabetic Retinopathy
Hypercholesterolemia
LDL Cholesterol
Therapeutics

Architecture of the Japan Ischemic Heart Disease Multimodal Prospective Data Acquisition for Precision Treatment (J-IMPACT) System

Matoba, T., Kohro, T., Fujita, H., Nakayama, M., Kiyosue, A., Miyamoto, Y., Nishimura, K., Hashimoto, H., Antoku, Y., Nakashima, N., Ohe, K., Ogawa, H., Tsutsui, H. & Nagai, R., Mar 20 2019, In : International heart journal. 60, 2, p. 264-270 7 p.

Research output: Contribution to journalArticle

Open Access
Percutaneous Coronary Intervention
Myocardial Ischemia
Japan
Coronary Angiography
Information Systems

Assessment of Coronary Flow Velocity Reserve in the Left Main Trunk Using Phase-contrast MR Imaging at 3T: Comparison with 15 O-labeled Water Positron Emission Tomography

Kikuchi, Y., Naya, M., Oyama-Manabe, N., Manabe, O., Sugimori, H., Kudo, K., Kato, F., Aikawa, T., Tsutsui, H., Tamaki, N. & Shirato, H., Apr 10 2019, In : Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine. 18, 2, p. 134-141 8 p.

Research output: Contribution to journalArticle

Open Access
Positron-Emission Tomography
Coronary Artery Disease
Water
Arteries
Contrast Media
Purkinje Fibers
Catheter Ablation
Ventricular Tachycardia
Verapamil
Electrodes

Colorectal endoscopic submucosal dissection using novel articulating devices: a comparative study in a live porcine model

Okamoto, Y., Nakadate, R., Nakamura, S., Arata, J., Oguri, S., Tomohiko, M., Esaki, M., iwasa, T., Ouchida, K., Akahoshi, T., Ikeda, T., Kitazono, T. & Hashizume, M., Feb 15 2019, In : Surgical endoscopy. 33, 2, p. 651-657 7 p.

Research output: Contribution to journalArticle

Swine
Equipment and Supplies
Endoscopic Mucosal Resection
Anal Canal
Colon
Open Access
Aortic Valve
Surgical Instruments
Pressure
Stroke
Stroke Volume
Mandibular Advancement
Obstructive Sleep Apnea
Blood Pressure
Equipment and Supplies
Sleep

Diabetes mellitus attenuates the pressure response against hypotensive stress by impairing the sympathetic regulation of the baroreflex afferent arc

Kamada, K., Saku, K., Tohyama, T., Kawada, T., Mannoji, H., Abe, K., Nishikawa, T., Sunagawa, G., Kishi, T., Sunagawa, K. & Tsutsui, H., Jan 1 2019, In : American Journal of Physiology - Heart and Circulatory Physiology. 316, 1, p. H35-H44

Research output: Contribution to journalArticle

Baroreflex
Diabetes Mellitus
Arterial Pressure
Pressure
Type 2 Diabetes Mellitus
Heart-Assist Devices
Suction
Transplants
Vasodilator Agents
Nitrates
Heart Failure
Databases
Hospitalization
1 Citation (Scopus)

Effects of coronary revascularization on global coronary flow reserve in stable coronary artery disease

Aikawa, T., Naya, M., Obara, M., Manabe, O., Magota, K., Koyanagawa, K., Asakawa, N., Ito, Y. M., Shiga, T., Katoh, C., Anzai, T., Tsutsui, H., Murthy, V. L. & Tamaki, N., Jan 1 2019, In : Cardiovascular research. 115, 1, p. 119-129 11 p.

Research output: Contribution to journalArticle

Coronary Artery Bypass
Percutaneous Coronary Intervention
Coronary Artery Disease
Positron-Emission Tomography
Multicenter Studies

Elevated non-invasive liver fibrosis markers and risk of liver carcinoma in adult patients after repair of tetralogy of Fallot

Yamamura, K., Sakamoto, I., Morihana, E., Hirata, Y., Nagata, H., Yamasaki, Y., Okumura, Y., Kouhashi, K., Koto, K., Tsutsui, H. & Ohga, S., Jul 15 2019, In : International Journal of Cardiology. 287, p. 121-126 6 p.

Research output: Contribution to journalArticle

Tetralogy of Fallot
Liver Cirrhosis
Carcinoma
Liver
Hyaluronic Acid

Estimation of the baroreflex total loop gain by the power spectral analysis of continuous arterial pressure recordings

Mannoji, H., Saku, K., Nishikawa, T., Tohyama, T., Kamada, K., Abe, K., Sunagawa, G., Kishi, T., Sunagawa, K. & Tsutsui, H., Apr 1 2019, In : American journal of physiology. Heart and circulatory physiology. 316, 4, p. H828-H839

Research output: Contribution to journalArticle

Baroreflex
Arterial Pressure
Denervation
Pressure
Carotid Sinus

Folding procedure to diminish type 3 endoleakage after open stent graft surgery with TEVAR extension

Onzuka, T., Furukawa, K., Tayama, E., Morita, S. & Shiose, A., Jan 1 2019, In : General thoracic and cardiovascular surgery.

Research output: Contribution to journalComment/debate

Thoracic Surgery
Stents
Transplants
Polyethylene Terephthalates
Thorax

Heart Failure Practice in Japan: Successful at Present, but Challenging in the Future

Tsutsui, H., Mar 1 2019, In : Journal of Cardiac Failure. 25, 3, p. 145-146 2 p.

Research output: Contribution to journalEditorial

Japan
Heart Failure

Hypoxia-inducible factor-1 α deletion in myeloid lineage attenuates hypoxia-induced pulmonary hypertension

Kojima, H., Tokunou, T., Takahara, Y., Sunagawa, K., Hirooka, Y., Ichiki, T. & Tsutsui, H., Apr 1 2019, In : Physiological Reports. 7, 7, e14025.

Research output: Contribution to journalArticle

Open Access
Hypoxia-Inducible Factor 1
Pulmonary Hypertension
Knockout Mice
Lung
Macrophages

Inhibition of TLR9-NF-κB-mediated sterile inflammation improves pressure overload-induced right ventricular dysfunction in rats

Yoshida, K., Abe, K., Ishikawa, M., Saku, K., Shinoda-Sakamoto, M., Ishikawa, T., Watanabe, T., Oka, M., Sunagawa, K. & Tsutsui, H., Mar 1 2019, In : Cardiovascular research. 115, 3, p. 658-668 11 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 9
Right Ventricular Dysfunction
Pulmonary Artery
Inflammation
Pressure

Ivabradine for the treatment of cardiovascular diseases

Ide, T., Ohtani, K., Higo, T., Tanaka, M., Kawasaki, Y. & Tsutsui, H., Feb 1 2019, In : Circulation Journal. 83, 2, p. 252-260 9 p.

Research output: Contribution to journalReview article

ivabradine
Cardiovascular Diseases
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels
Sinoatrial Node
Heart Failure

Liprin-α4 as a new therapeutic target for SCLC as an upstream mediator of HIF1α

Ohnishi, H., Yamasaki, A., Nakamura, K., Ichimiya, S., Yanai, K., Umebayashi, M., Nagai, S. & Morisaki, T., Mar 1 2019, In : Anticancer research. 39, 3, p. 1179-1184 6 p.

Research output: Contribution to journalArticle

Small Cell Lung Carcinoma
Cell Hypoxia
Cisplatin
CD45 Antigens
Hypoxia-Inducible Factor 1
4 Citations (Scopus)

Mechano-chronotropic Unloading During the Acute Phase of Myocardial Infarction Markedly Reduces Infarct Size via the Suppression of Myocardial Oxygen Consumption

Sunagawa, G., Saku, K., Arimura, T., Nishikawa, T., Mannoji, H., Kamada, K., Abe, K., Kishi, T., Tsutsui, H. & Sunagawa, K., Apr 15 2019, In : Journal of Cardiovascular Translational Research. 12, 2, p. 124-134 11 p.

Research output: Contribution to journalArticle

ivabradine
Oxygen Consumption
Myocardial Infarction
Ischemia
Reperfusion

Pancreatic Juice Exosomal MicroRNAs as Biomarkers for Detection of Pancreatic Ductal Adenocarcinoma

Nakamura, S., Sadakari, Y., Takao, O., Okayama, T., Nakashima, Y., Gotoh, Y., Saeki, K., Mori, Y., Nakata, K., Miyasaka, Y., Ohnishi, H., Oda, Y., Goggins, M. & Nakamura, M., Jan 1 2019, In : Annals of Surgical Oncology.

Research output: Contribution to journalArticle

Pancreatic Juice
MicroRNAs
Adenocarcinoma
Biomarkers
Exosomes

Pectoral Muscle Atrophy After Axillary Artery Cannulation for Aortic Arch Surgery

Imasaka, K. I., Tomita, Y., Nishijima, T., Tayama, E., Morita, S., Toriya, R. & Shiose, A., Jan 1 2019, In : Seminars in Thoracic and Cardiovascular Surgery.

Research output: Contribution to journalArticle

Axillary Artery
Pectoralis Muscles
Muscular Atrophy
Thoracic Aorta
Catheterization
Myocarditis
Thrombosis
Pediatrics
Equipment and Supplies
Extracorporeal Membrane Oxygenation

Peroxisome proliferator-activated receptor-gamma targeting nanomedicine promotes cardiac healing after acute myocardial infarction by skewing monocyte/macrophage polarization in preclinical animal models

Tokutome, M., Matoba, T., Nakano, Y., Okahara, A., Fujiwara, M., Koga, J. I., Nakano, K., Tsutsui, H. & Egashira, K., Feb 1 2019, In : Cardiovascular research. 115, 2, p. 419-431 13 p.

Research output: Contribution to journalArticle

pioglitazone
Nanomedicine
PPAR gamma
Monocytes
Animal Models

Possible associations between palliative care conferences and positive outcomes when performing palliative care for patients with end-stage heart failure: a nationwide cross-sectional questionnaire survey

Kurozumi, Y., Oishi, S., Sugano, Y., Sakashita, A., Kotooka, N., Suzuki, M., Higo, T., Yumino, D., Takada, Y., Maeda, S., Yamabe, S., Washida, K., Takahashi, T., Ohtani, T., Sakata, Y. & Sato, Y., Mar 15 2019, In : Heart and Vessels. 34, 3, p. 452-461 10 p.

Research output: Contribution to journalArticle

Palliative Care
Heart Failure
Cross-Sectional Studies
Nutritionists
Surveys and Questionnaires

Predictive value of the induction test with atrial burst pacing with regard to long-term recurrence after ablation in persistent atrial fibrillation

Kawai, S., Mukai, Y., Inoue, S., Yakabe, D., Nagaoka, K., Sakamoto, K., Takase, S., Chishaki, A. & Tsutsui, H., Jan 1 2019, (Accepted/In press) In : journal of arrhythmia.

Research output: Contribution to journalArticle

Predictive Value of Tests
Atrial Fibrillation
Tachycardia
Recurrence
Catheter Ablation

Prescription rates of guideline-directed medications are associated with in-hospital mortality among Japanese patients with acute myocardial infarction: A report from JROAD-DPC study

Nakao, K., Yasuda, S., Nishimura, K., Noguchi, T., Nakai, M., Miyamoto, Y., Sumita, Y., Shishido, T., Anzai, T., Ito, H., Tsutsui, H., Saito, Y., Komuro, I. & Ogawa, H., Jan 1 2019, In : Journal of the American Heart Association. 8, 7, e009692.

Research output: Contribution to journalArticle

Open Access
Hospital Mortality
Prescriptions
Myocardial Infarction
Guidelines
Peptidyl-Dipeptidase A

Surgical treatment: Laparoscopic splenectomy

Hashizume, M. & Akahoshi, T., Jan 1 2019, Clinical Investigation of Portal Hypertension. Springer Singapore, p. 447-459 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Esophageal and Gastric Varices
Portal Hypertension
Splenectomy
Liver Cirrhosis
Laparoscopy

Thoracic endografting increases cardiac afterload and leads to left ventricular hypertrophy in dogs

Yamashita, Y., Oishi, Y., Motomatsu, Y., Hirayama, K., Harada, T., Ushijima, T., fujita, S., Kimura, S., Sonoda, H., Tatewaki, H., Tanoue, Y., Sunagawa, G., Nishikawa, T., Saku, K. & Shiose, A., Apr 1 2019, In : European Journal of Cardio-thoracic Surgery. 55, 4, p. 618-625 8 p.

Research output: Contribution to journalArticle

Left Ventricular Hypertrophy
Electric Impedance
Thorax
Dogs
Cardiac Myocytes
Right Ventricular Dysfunction
Pulmonary Hypertension
Electrocardiography

Unexpected, but reasonable association between anderson-fabry disease and coronary vasospasm

Matoba, T., Nakano, Y. & Tsutsui, H., Feb 1 2019, In : Circulation Journal. 83, 2, p. 283-284 2 p.

Research output: Contribution to journalArticle

Coronary Vasospasm
Fabry Disease
2018

Acute Swine Model for Assessing Biocompatibility of Biomedical Interface Materials

Takaseya, T., Fumoto, H., Zhu, J., Shiose, A., Kobayashi, M., Fujiki, M., Arakawa, Y., Dessoffy, R., Kramer, L. D. & Fukamachi, K., Feb 1 2018, In : Tissue Engineering - Part C: Methods. 24, 2, p. 69-73 5 p.

Research output: Contribution to journalArticle

Biocompatibility
Blood
Swine
Blood Cell Count
Biocompatible Materials
2 Citations (Scopus)

A new robotic-assisted flexible endoscope with single-hand control: endoscopic submucosal dissection in the ex vivo porcine stomach

iwasa, T., Nakadate, R., Onogi, S., Okamoto, Y., Arata, J., Oguri, S., Ogino, H., Ihara, E., Ouchida, K., Akahoshi, T., Ikeda, T., Ogawa, Y. & Hashizume, M., Jul 1 2018, In : Surgical Endoscopy. 32, 7, p. 3386-3392 7 p.

Research output: Contribution to journalArticle

Endoscopes
Robotics
Stomach
Swine
Hand
2 Citations (Scopus)

Angiotensin receptor neprilysin inhibitor in Japanese patients with heart failure and reduced ejection fraction: Baseline characteristics and treatment of PARALLEL-HF trial

Tsutsui, H., Momomura, S. I., Saito, Y., Ito, H., Yamamoto, K., Ohishi, T., Okino, N., Kitamura, T. & Guo, W., Jan 1 2018, In : Circulation Journal. 82, 10, p. 2575-2583 9 p.

Research output: Contribution to journalArticle

Neprilysin
Angiotensin Receptors
Heart Failure
Therapeutics
Registries
1 Citation (Scopus)

A novel histological examination with dynamic three-dimensional reconstruction from multiple immunohistochemically stained sections of a PD-L1-positive colon cancer

Korehisa, S., Ikeda, T., Okano, S., Saeki, H., Oki, E., Oda, Y., Hashizume, M. & Maehara, Y., Mar 1 2018, In : Histopathology. 72, 4, p. 697-703 7 p.

Research output: Contribution to journalArticle

Colonic Neoplasms
Cell Death
Ligands
Microsatellite Instability
Neoplasms

Anticoagulation therapy after left ventricular assist device implantation

Tanoue, Y., Fujino, T. & Shiose, A., Jan 1 2018, In : Circulation Journal. 82, 5, p. 1245-1246 2 p.

Research output: Contribution to journalEditorial

Heart-Assist Devices
Therapeutics
4 Citations (Scopus)

Antithrombin III for portal vein thrombosis in patients with liver disease: A randomized, double-blind, controlled trial

The NPB-06 study group, Feb 1 2018, In : Hepatology Research. 48, 3, p. E107-E116

Research output: Contribution to journalArticle

Antithrombin III
Portal Vein
Liver Diseases
Thrombosis
Placebos

Association of peripartum troponin i levels with left ventricular relaxation in women with hypertensive disorders of pregnancy

Umazume, T., Yamada, S., Yamada, T., Ishikawa, S., Furuta, I., Iwano, H., Murai, D., Hayashi, T., Okada, K., Morikawa, M., Tsutsui, H. & Minakami, H., Jan 1 2018, In : Open Heart. 5, 2, e000829.

Research output: Contribution to journalArticle

Peripartum Period
Troponin
Postpartum Period
Pregnancy
Troponin I
20 Citations (Scopus)

Astrocyte reactivity and astrogliosis after spinal cord injury

Okada, S., Hara, M., Kobayakawa, K., Matsumoto, Y. & Nakashima, Y., Jan 1 2018, In : Neuroscience Research. 126, p. 39-43 5 p.

Research output: Contribution to journalReview article

Spinal Cord Injuries
Astrocytes
Cicatrix
Neuroglia
Central Nervous System

Axillo-iliac artery bypass for recurrent aortic coarctation to reduce cardiac afterload

Yamashita, Y., Tatewaki, H., Matsumoto, T. & Shiose, A., Oct 1 2018, In : Interactive cardiovascular and thoracic surgery. 27, 4, p. 626-628 3 p.

Research output: Contribution to journalArticle

Aortic Coarctation
Defibrillators
Iliac Artery
Blood Pressure
Long QT Syndrome
1 Citation (Scopus)
Balloon Angioplasty
Pulmonary Hypertension
Hemodynamics
Lung
Angioplasty

Brain-derived neurotrophic factor improves limited exercise capacity in mice with heart failure

Matsumoto, J., Takada, S., Kinugawa, S., Furihata, T., Nambu, H., Kakutani, N., Tsuda, M., Fukushima, A., Yokota, T., Tanaka, S., Takahashi, H., Watanabe, M., Hatakeyama, S., Matsumoto, M., Nakayama, K., Otsuka, Y., Sabe, H., Tsutsui, H. & Anzai, T., Jan 1 2018, In : Circulation. 138, 18, p. 2064-2066 3 p.

Research output: Contribution to journalLetter

Brain-Derived Neurotrophic Factor
Heart Failure

Catumaxomab with activated T-cells efficiently lyses chemoresistant EpCAM-positive triple-negative breast cancer cell lines

Kubo, M., Umebayashi, M., Kurata, K., Mori, H., Kai, M., Ohnishi, H., Katano, M., Nakamura, M. & Morisaki, T., Jul 1 2018, In : Anticancer Research. 38, 7, p. 4273-4279 7 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
T-Lymphocytes
Cell Line
Breast Neoplasms
Bispecific Antibodies
5 Citations (Scopus)

Clinical results, adverse events, and change in end-organ function in elderly patients with heartmateii left ventricular assist device: Japanese multicenter study

behalf of the Japanese HeartMateII Investigators, Jan 1 2018, In : Circulation Journal. 82, 2, p. 409-418 10 p.

Research output: Contribution to journalArticle

Heart-Assist Devices
Multicenter Studies
Stroke
Incidence
Serum Albumin
1 Citation (Scopus)

Combined gemcitabine and metronidazole is a promising therapeutic strategy for cancer stem-like cholangiocarcinoma

Kawamoto, M., Umebayashi, M., Tanaka, H., Koya, N., Nakagawa, S., Kawabe, K., Ohnishi, H., Nakamura, M. & Morisaki, T., May 1 2018, In : Anticancer research. 38, 5, p. 2739-2748 10 p.

Research output: Contribution to journalArticle

gemcitabine
Cholangiocarcinoma
Metronidazole
Aldehyde Dehydrogenase
Neoplasms

Constrictive Pericarditis and Worsening Mitral Annular Disjunction After Long-Term Chylopericardium

Uchikawa, T., Ohtani, K., Muramatsu, K., Sonoda, H., Shiose, A. & Tsutsui, H., Aug 1 2018, In : Circulation. Heart failure. 11, 8, p. e004698

Research output: Contribution to journalArticle

Chyle
Constrictive Pericarditis
Pericardial Effusion
Mitral Valve Insufficiency
Inflammation

Customization of laparoscopic gastric devascularization and splenectomy for gastric varices based on CT vascular anatomy

Kawanaka, H., Akahoshi, T., Nagao, Y., Kinjo, N., Yoshida, D., Matsumoto, Y., Harimoto, N., itoh, S., Yoshizumi, T. & Maehara, Y., Jan 1 2018, In : Surgical endoscopy. 32, 1, p. 114-126 13 p.

Research output: Contribution to journalArticle

Esophageal and Gastric Varices
Splenectomy
Blood Vessels
Anatomy
Stomach
3 Citations (Scopus)

Design of a nationwide survey on palliative care for end-stage heart failure in Japan

Kurozumi, Y., Oishi, S., Sugano, Y., Sakashita, A., Kotooka, N., Suzuki, M., Higo, T., Yumino, D., Takada, Y., Maeda, S., Yamabe, S., Washida, K., Takahashi, T., Ohtani, T., Sakata, Y. & Sato, Y., Feb 1 2018, In : Journal of Cardiology. 71, 2, p. 202-211 10 p.

Research output: Contribution to journalArticle

Palliative Care
Japan
Heart Failure
Surveys and Questionnaires
Advance Care Planning