Department of Advanced Medical Initiatives

Research Output 1980 2019

2019

2,5-Dimethylcelecoxib prevents isoprenaline-induced cardiomyocyte hypertrophy and cardiac fibroblast activation by inhibiting Akt-mediated GSK-3 phosphorylation

Morishige, S., Takahashi-Yanaga, F., Ishikane, S., arioka, M., Igawa, K., Kuroo, A., Tomooka, K., Shiose, A. & Sasaguri, T., Oct 1 2019, In : Biochemical Pharmacology. 168, p. 82-90 9 p.

Research output: Contribution to journalArticle

Glycogen Synthase Kinase 3
Phosphorylation
Cardiomegaly
Fibroblasts
Isoproterenol

A case of acute exacerbation of chronic adrenal insufficiency due to ipilimumab treatment for advanced melanoma

Sakaguchi, C., Yano, S., Ashida, K., Wada, N., Ohe, K., Nagata, H., matsuda, Y., Sakamoto, S., Sakamoto, R., Keizo, O., Hiroshi, U., Furue, M., Nomura, M. & Ogawa, Y., Jan 1 2019, In : American Journal of Case Reports. 20, p. 106-110 5 p.

Research output: Contribution to journalArticle

Adrenal Insufficiency
Melanoma
Therapeutics
Programmed Cell Death 1 Receptor
ipilimumab
1 Citation (Scopus)
Open Access
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Diabetic Retinopathy
Hypercholesterolemia
LDL Cholesterol
Therapeutics

Architecture of the Japan ischemic heart disease multimodal prospective data acquisition for precision treatment (J-IMPACT) system

Matoba, T., Kohro, T., Fujita, H., Nakayama, M., Kiyosue, A., Miyamoto, Y., Nishimura, K., Hashimoto, H., Antoku, Y., Nakashima, N., Ohe, K., Ogawa, H., Tsutsui, H. & Nagai, R., Jan 1 2019, In : International heart journal. 60, 2, p. 264-270 7 p.

Research output: Contribution to journalArticle

Open Access
Percutaneous Coronary Intervention
Myocardial Ischemia
Japan
Coronary Angiography
Information Systems

Assessment of coronary flow velocity reserve in the left main trunk using phase-contrast MR imaging at 3T: Comparison with 15O-labeled water positron emission tomography

Kikuchi, Y., Naya, M., Manabe, N. O., Manabe, O., Sugimori, H., Kudo, K., Kato, F., Aikawa, T., Tsutsui, H., Tamaki, N. & Shirato, H., Jan 1 2019, In : Magnetic Resonance in Medical Sciences. 18, 2, p. 134-141 8 p.

Research output: Contribution to journalArticle

Open Access
Positron-Emission Tomography
Coronary Artery Disease
Water
Arteries
Contrast Media

Baseline demographics and clinical characteristics in the all nippon af in the elderly (ANAFIE) registry

Koretsune, Y., Yamashita, T., Akao, M., Atarashi, H., Ikeda, T., Okumura, K., Shimizu, W., Tsutsui, H., Toyoda, K., Hirayama, A., Yasaka, M., Yamaguchi, T., Teramukai, S., Kimura, T., Kaburagi, J., Takita, A. & Inoue, H., Jan 1 2019, In : Circulation Journal. 83, 7, p. 1538-1545 8 p.

Research output: Contribution to journalArticle

Open Access
Registries
Demography
Anticoagulants
Atrial Fibrillation
Prospective Studies

Cardioprotective effect of renin–angiotensin inhibitors and β-blockers in trastuzumab-related cardiotoxicity

Ohtani, K., Ide, T., Ken-Ichi, H., Sakamoto, I., Yamashita, N., Kubo, M. & Tsutsui, H., Jan 1 2019, (Accepted/In press) In : Clinical Research in Cardiology.

Research output: Contribution to journalArticle

Anthracyclines
Left Ventricular Dysfunction
Breast Neoplasms
Heart Failure
Cardiotoxicity
Purkinje Fibers
Catheter Ablation
Ventricular Tachycardia
Verapamil
Electrodes

Colorectal endoscopic submucosal dissection using novel articulating devices: a comparative study in a live porcine model

Okamoto, Y., Nakadate, R., Nakamura, S., Arata, J., Oguri, S., Tomohiko, M., Esaki, M., iwasa, T., Ouchida, K., Akahoshi, T., Ikeda, T., Kitazono, T. & Hashizume, M., Feb 15 2019, In : Surgical endoscopy. 33, 2, p. 651-657 7 p.

Research output: Contribution to journalArticle

Swine
Equipment and Supplies
Endoscopic Mucosal Resection
Anal Canal
Colon
Open Access
Aortic Valve
Surgical Instruments
Pressure
Stroke
Stroke Volume

Congenitally Corrected Transposition of the Great Arteries( TGA) in Adult

Tatewaki, H., Sakamoto, I., Hirayama, K. & Shiose, A., Apr 1 2019, In : Kyobu geka. The Japanese journal of thoracic surgery. 72, 4, p. 269-274 6 p.

Research output: Contribution to journalArticle

Heart Ventricles
Tricuspid Valve
Ventricular Heart Septal Defects
Reoperation
Pulmonary Artery
Mandibular Advancement
Obstructive Sleep Apnea
Blood Pressure
Equipment and Supplies
Sleep

Diabetes mellitus attenuates the pressure response against hypotensive stress by impairing the sympathetic regulation of the baroreflex afferent arc

Kamada, K., Saku, K., Tohyama, T., Kawada, T., Mannoji, H., Abe, K., Nishikawa, T., Sunagawa, G., Kishi, T., Sunagawa, K. & Tsutsui, H., Jan 1 2019, In : American Journal of Physiology - Heart and Circulatory Physiology. 316, 1, p. H35-H44

Research output: Contribution to journalArticle

Baroreflex
Diabetes Mellitus
Arterial Pressure
Pressure
Type 2 Diabetes Mellitus
Heart-Assist Devices
Suction
Transplants
2 Citations (Scopus)

Early therapeutic effects of adaptive servo-ventilation on cardiac sympathetic nervous function in patients with heart failure evaluated using a combination of 11C-HED PET and 123I-MIBG SPECT

Tokuda, Y., Sakakibara, M., Yoshinaga, K., Yamada, S., Kamiya, K., Asakawa, N., Yoshitani, T., Noguchi, K., Manabe, O., Tamaki, N. & Tsutsui, H., Aug 15 2019, In : Journal of Nuclear Cardiology. 26, 4, p. 1079-1089 11 p.

Research output: Contribution to journalArticle

Therapeutic Uses
Single-Photon Emission-Computed Tomography
Ventilation
Heart Failure
Brain Natriuretic Peptide
Vasodilator Agents
Nitrates
Heart Failure
Databases
Hospitalization
1 Citation (Scopus)

Effects of coronary revascularization on global coronary flow reserve in stable coronary artery disease

Aikawa, T., Naya, M., Obara, M., Manabe, O., Magota, K., Koyanagawa, K., Asakawa, N., Ito, Y. M., Shiga, T., Katoh, C., Anzai, T., Tsutsui, H., Murthy, V. L. & Tamaki, N., Jan 1 2019, In : Cardiovascular research. 115, 1, p. 119-129 11 p.

Research output: Contribution to journalArticle

Coronary Artery Bypass
Percutaneous Coronary Intervention
Coronary Artery Disease
Positron-Emission Tomography
Multicenter Studies

Elevated non-invasive liver fibrosis markers and risk of liver carcinoma in adult patients after repair of tetralogy of Fallot

Yamamura, K., Sakamoto, I., Morihana, E., Hirata, Y., Nagata, H., Yamasaki, Y., Okumura, Y., Kouhashi, K., Koto, K., Tsutsui, H. & Ohga, S., Jul 15 2019, In : International Journal of Cardiology. 287, p. 121-126 6 p.

Research output: Contribution to journalArticle

Tetralogy of Fallot
Liver Cirrhosis
Carcinoma
Liver
Hyaluronic Acid
1 Citation (Scopus)

Estimation of the baroreflex total loop gain by the power spectral analysis of continuous arterial pressure recordings

Mannoji, H., Saku, K., Nishikawa, T., Tohyama, T., Kamada, K., Abe, K., Sunagawa, G., Kishi, T., Sunagawa, K. & Tsutsui, H., Apr 1 2019, In : American Journal of Physiology - Heart and Circulatory Physiology. 316, 4, p. H828-H839

Research output: Contribution to journalArticle

Baroreflex
Arterial Pressure
Denervation
Pressure
Carotid Sinus
Open Access
Heart-Assist Devices
Thrombosis
Transplants
Architectural Accessibility
Heart Failure

Folding procedure to diminish type 3 endoleakage after open stent graft surgery with TEVAR extension

Onzuka, T., Furukawa, K., Tayama, E., Morita, S. & Shiose, A., Jan 1 2019, In : General thoracic and cardiovascular surgery.

Research output: Contribution to journalComment/debate

Thoracic Surgery
Stents
Transplants
Polyethylene Terephthalates
Thorax

Heart Failure Practice in Japan: Successful at Present, but Challenging in the Future

Tsutsui, H., Mar 1 2019, In : Journal of Cardiac Failure. 25, 3, p. 145-146 2 p.

Research output: Contribution to journalEditorial

Japan
Heart Failure
4 Citations (Scopus)

Heart failure with reduced ejection fraction: comparison of patient characteristics and clinical outcomes within Asia and between Asia, Europe and the Americas

Dewan, P., Jhund, P. S., Shen, L., Petrie, M. C., Abraham, W. T., Atif Ali, M., Chen, C. H., Desai, A. S., Dickstein, K., Huang, J., Kiatchoosakun, S., Kim, K. S., Køber, L., Lai, W. T., Liao, Y., Mogensen, U. M., Oh, B. H., Packer, M., Rouleau, J. L., Shi, V. & 7 others, Sibulo, A. S., Solomon, S. D., Sritara, P., Swedberg, K., Tsutsui, H., Zile, M. R. & McMurray, J. J. V., May 1 2019, In : European Journal of Heart Failure. 21, 5, p. 577-587 11 p.

Research output: Contribution to journalArticle

Open Access
Heart Failure
North America
Philippines
China
Taiwan

Hospitalization costs for patients with acute congestive heart failure in Japan

Kanaoka, K., Okayama, S., Nakai, M., Sumita, Y., Nishimura, K., Kawakami, R., Okura, H., Miyamoto, Y., Yasuda, S., Tsutsui, H., Komuro, I., Ogawa, H. & Saito, Y., Jan 1 2019, In : Circulation Journal. 83, 5, p. 1025-1031 7 p.

Research output: Contribution to journalArticle

Open Access
Japan
Hospitalization
Heart Failure
Costs and Cost Analysis
Acute Disease

Hypoxia-inducible factor-1 α deletion in myeloid lineage attenuates hypoxia-induced pulmonary hypertension

Kojima, H., Tokunou, T., Takahara, Y., Sunagawa, K., Hirooka, Y., Ichiki, T. & Tsutsui, H., Apr 1 2019, In : Physiological Reports. 7, 7, e14025.

Research output: Contribution to journalArticle

Open Access
Hypoxia-Inducible Factor 1
Pulmonary Hypertension
Knockout Mice
Lung
Macrophages
1 Citation (Scopus)

Implication of preoperative existence of atrial fibrillation on hemocompatibility-related adverse events during left ventricular assist device support

Imamura, T., Kinugawa, K., Ono, M., Kinoshita, O., Fukushima, N., Shiose, A., Matsui, Y., Yamazaki, K., Saiki, Y., Usui, A., Niinami, H., Matsumiya, G., Arai, H. & Sawa, Y., Jan 1 2019, In : Circulation Journal. 83, 6, p. 1286-1292 7 p.

Research output: Contribution to journalArticle

Open Access
Heart-Assist Devices
Atrial Fibrillation
Propensity Score
Registries
Thrombosis

Inconsistency in the standard of care-toward evidence-based management of exertional heat stroke

Hosokawa, Y., Nagata, T. & Hasegawa, M., Jan 1 2019, In : Frontiers in Physiology. 10, FEB, 108.

Research output: Contribution to journalReview article

Open Access
Heat Stroke
Standard of Care
Extreme Heat
Tokyo
Hot Temperature

Inhibition of TLR9-NF-κB-mediated sterile inflammation improves pressure overload-induced right ventricular dysfunction in rats

Yoshida, K., Abe, K., Ishikawa, M., Saku, K., Shinoda-Sakamoto, M., Ishikawa, T., Watanabe, T., Oka, M., Sunagawa, K. & Tsutsui, H., Mar 1 2019, In : Cardiovascular research. 115, 3, p. 658-668 11 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 9
Right Ventricular Dysfunction
Pulmonary Artery
Inflammation
Pressure

Involvement of different receptor subtypes in prostaglandin E2-induced contraction and relaxation in the lower esophageal sphincter and esophageal body

Bai, X., Ihara, E., Otsuka, Y., Tsuruta, S., Hirano, K., Tanaka, Y., Ogino, H., Hirano, M., Chinen, T., Akiho, H., Nakamura, K., Oda, Y. & Ogawa, Y., Aug 15 2019, In : European Journal of Pharmacology. 857, 172405.

Research output: Contribution to journalArticle

Lower Esophageal Sphincter
Dinoprostone
Smooth Muscle
Gastroesophageal Reflux
Muscle Contraction
1 Citation (Scopus)

Ivabradine for the treatment of cardiovascular diseases

Ide, T., Ohtani, K., Higo, T., Tanaka, M., Kawasaki, Y. & Tsutsui, H., Feb 1 2019, In : Circulation Journal. 83, 2, p. 252-260 9 p.

Research output: Contribution to journalReview article

ivabradine
Cardiovascular Diseases
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels
Sinoatrial Node
Heart Failure

Japanese periodical nationwide epidemiologic survey of aberrant portal hemodynamics

Ohfuji, S., Furuichi, Y., Akahoshi, T., Kage, M., Obara, K., Hashizume, M., Matsuura, T., Fukushima, W. & Nakamura, Y., Aug 1 2019, In : Hepatology Research. 49, 8, p. 890-901 12 p.

Research output: Contribution to journalArticle

Open Access
Hemodynamics
Japan
Pediatrics
Epidemiologic Methods
Surveys and Questionnaires

Jarvik 2000 axial flow ventricular assist device in right single ventricle after Fontan operation

Tanoue, Y., Fujino, T., Tatewaki, H. & Shiose, A., Jan 1 2019, (Accepted/In press) In : Journal of Artificial Organs.

Research output: Contribution to journalArticle

Fontan Procedure
Heart-Assist Devices
Axial flow
Heart Ventricles
Dextrocardia
1 Citation (Scopus)

JCS 2018 guideline on diagnosis and treatment of acute coronary syndrome

on behalf of the Japanese Circulation Society Joint Working Group, Jan 1 2019, In : Circulation Journal. 83, 5, p. 1085-1196 112 p.

Research output: Contribution to journalArticle

Open Access
Acute Coronary Syndrome
Guidelines
1 Citation (Scopus)

Left atrial involvement of cardiac sarcoidosis manifesting as left atrial re-entrant tachycardia

Enzan, N., Ohtani, K., Nagaoka, K., Sakamoto, I. & Tsutsui, H., Aug 1 2019, In : European heart journal cardiovascular Imaging. 20, 8, 1 p., jez051.

Research output: Contribution to journalComment/debate

Sarcoidosis
Tachycardia

Liprin-α4 as a new therapeutic target for SCLC as an upstream mediator of HIF1α

Ohnishi, H., Yamasaki, A., Nakamura, K., Ichimiya, S., Yanai, K., Umebayashi, M., Nagai, S. & Morisaki, T., Mar 1 2019, In : Anticancer research. 39, 3, p. 1179-1184 6 p.

Research output: Contribution to journalArticle

Small Cell Lung Carcinoma
Cell Hypoxia
Cisplatin
CD45 Antigens
Hypoxia-Inducible Factor 1
3 Citations (Scopus)

Mechano-chronotropic Unloading During the Acute Phase of Myocardial Infarction Markedly Reduces Infarct Size via the Suppression of Myocardial Oxygen Consumption

Sunagawa, G., Saku, K., Arimura, T., Nishikawa, T., Mannoji, H., Kamada, K., Abe, K., Kishi, T., Tsutsui, H. & Sunagawa, K., Apr 15 2019, In : Journal of Cardiovascular Translational Research. 12, 2, p. 124-134 11 p.

Research output: Contribution to journalArticle

ivabradine
Oxygen Consumption
Myocardial Infarction
Ischemia
Reperfusion

Nanoparticle incorporating Toll-like receptor 4 inhibitor attenuates myocardial ischaemia-reperfusion injury by inhibiting monocyte-mediated inflammation in mice

Fujiwara, M., Matoba, T., Koga, J-I., Okahara, A., Funamoto, D., Nakano, K., Tsutsui, H. & Egashira, K., Jun 1 2019, In : Cardiovascular research. 115, 7, p. 1244-1255 12 p.

Research output: Contribution to journalArticle

Myocardial Reperfusion Injury
Toll-Like Receptor 4
Reperfusion Injury
Nanoparticles
Myocardial Ischemia

Nanoparticle incorporating Toll-like receptor 4 inhibitor attenuates myocardial ischaemia-reperfusion injury by inhibiting monocyte-mediated inflammation in mice

Fujiwara, M., Matoba, T., Koga, J. I., Okahara, A., Funamoto, D., Nakano, K., Tsutsui, H. & Egashira, K., Jun 1 2019, In : Cardiovascular research. 115, 7, p. 1244-1255 12 p.

Research output: Contribution to journalArticle

Open Access
Myocardial Reperfusion Injury
Toll-Like Receptor 4
Reperfusion Injury
Nanoparticles
Myocardial Ischemia

Nationwide survey of multidisciplinary care and cardiac rehabilitation for patients with heart failure in Japan ― An analysis of the AMED-CHF study ―

Kamiya, K., Yamamoto, T., Tsuchihashi-Makaya, M., Ikegame, T., Takahashi, T., Sato, Y., Kotooka, N., Saito, Y., Tsutsui, H., Miyata, H. & Isobe, M., Jan 1 2019, In : Circulation Journal. 83, 7, p. 1546-1552 7 p.

Research output: Contribution to journalArticle

Open Access
Japan
Heart Failure
Outpatients
Inpatients
Cardiac Rehabilitation

Non-Pulmonary Vein Triggers of Atrial Fibrillation Are Likely to Arise from Low-Voltage Areas in the Left Atrium

Kawai, S., Mukai, Y., Inoue, S., Yakabe, D., Nagaoka, K., Sakamoto, K., Takase, S., Chishaki, A. & Tsutsui, H., Dec 1 2019, In : Scientific reports. 9, 1, 12271.

Research output: Contribution to journalArticle

Open Access
Heart Atria
Atrial Fibrillation
Veins
Catheter Ablation
Open Access
Brain Natriuretic Peptide
Dementia
Population
Serum
Alzheimer Disease

Number of Cardiologists per Cardiovascular Beds and In-Hospital Mortality for Acute Heart Failure: A Nationwide Study in Japan

Kanaoka, K., Okayama, S., Nakai, M., Sumita, Y., Onoue, K., Soeda, T., Nishimura, K., Kawakami, R., Okura, H., Miyamoto, Y., Yasuda, S., Tsutsui, H., Komuro, I., Ogawa, H. & Saito, Y., Sep 17 2019, In : Journal of the American Heart Association. 8, 18, p. e012282

Research output: Contribution to journalArticle

Open Access
Hospital Mortality
Japan
Heart Failure
Emergencies
Odds Ratio

Pancreatic Juice Exosomal MicroRNAs as Biomarkers for Detection of Pancreatic Ductal Adenocarcinoma

Nakamura, S., Sadakari, Y., Takao, O., Okayama, T., Nakashima, Y., Gotoh, Y., Saeki, K., Mori, Y., Nakata, K., Miyasaka, Y., Ohnishi, H., Oda, Y., Goggins, M. & Nakamura, M., Jul 15 2019, In : Annals of Surgical Oncology. 26, 7, p. 2104-2111 8 p.

Research output: Contribution to journalArticle

Pancreatic Juice
MicroRNAs
Adenocarcinoma
Biomarkers
Exosomes

Pectoral Muscle Atrophy After Axillary Artery Cannulation for Aortic Arch Surgery

Imasaka, K. I., Tomita, Y., Nishijima, T., Tayama, E., Morita, S., Toriya, R. & Shiose, A., Sep 1 2019, In : Seminars in Thoracic and Cardiovascular Surgery. 31, 3, p. 414-421 8 p.

Research output: Contribution to journalArticle

Axillary Artery
Pectoralis Muscles
Muscular Atrophy
Thoracic Aorta
Catheterization
Myocarditis
Thrombosis
Pediatrics
Equipment and Supplies
Extracorporeal Membrane Oxygenation
3 Citations (Scopus)

Peroxisome proliferator-activated receptor-gamma targeting nanomedicine promotes cardiac healing after acute myocardial infarction by skewing monocyte/macrophage polarization in preclinical animal models

Tokutome, M., Matoba, T., Nakano, Y., Okahara, A., Fujiwara, M., Koga, J. I., Nakano, K., Tsutsui, H. & Egashira, K., Feb 1 2019, In : Cardiovascular research. 115, 2, p. 419-431 13 p.

Research output: Contribution to journalArticle

pioglitazone
Nanomedicine
PPAR gamma
Monocytes
Animal Models

Possible associations between palliative care conferences and positive outcomes when performing palliative care for patients with end-stage heart failure: a nationwide cross-sectional questionnaire survey

Kurozumi, Y., Oishi, S., Sugano, Y., Sakashita, A., Kotooka, N., Suzuki, M., Higo, T., Yumino, D., Takada, Y., Maeda, S., Yamabe, S., Washida, K., Takahashi, T., Ohtani, T., Sakata, Y. & Sato, Y., Mar 15 2019, In : Heart and Vessels. 34, 3, p. 452-461 10 p.

Research output: Contribution to journalArticle

Palliative Care
Heart Failure
Cross-Sectional Studies
Nutritionists
Surveys and Questionnaires

Predictive value of the induction test with atrial burst pacing with regard to long-term recurrence after ablation in persistent atrial fibrillation

Kawai, S., Mukai, Y., Inoue, S., Yakabe, D., Nagaoka, K., Sakamoto, K., Takase, S., Chishaki, A. & Tsutsui, H., Jan 1 2019, (Accepted/In press) In : journal of arrhythmia.

Research output: Contribution to journalArticle

Predictive Value of Tests
Atrial Fibrillation
Tachycardia
Recurrence
Catheter Ablation

Prescription rates of guideline-directed medications are associated with in-hospital mortality among Japanese patients with acute myocardial infarction: A report from JROAD-DPC study

Nakao, K., Yasuda, S., Nishimura, K., Noguchi, T., Nakai, M., Miyamoto, Y., Sumita, Y., Shishido, T., Anzai, T., Ito, H., Tsutsui, H., Saito, Y., Komuro, I. & Ogawa, H., Jan 1 2019, In : Journal of the American Heart Association. 8, 7, e009692.

Research output: Contribution to journalArticle

Open Access
Hospital Mortality
Prescriptions
Myocardial Infarction
Guidelines
Peptidyl-Dipeptidase A