Department of Advanced Medical Initiatives

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2017

Brain-derived neurotrophic factor/tropomyosin-related kinase B signaling pathway contributes to the aggressive behavior of lung squamous cell carcinoma

Ozono, K., Ohishi, Y., Onishi, H., Nakamura, K., Motoshita, J., Kato, M., Nakanishi, R., Nakamura, M. & Oda, Y., Nov 1 2017, In : Laboratory Investigation. 97, 11, p. 1332-1342 11 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Cancer-associated peritoneal mesothelial cells lead the formation of pancreatic cancer peritoneal dissemination

Abe, T., Ohuchida, K., Koikawa, K., Endo, S., Okumura, T., Sada, M., Horioka, K., Zheng, B., Moriyama, T., Nakata, K., Miyasaka, Y., Manabe, T., Ohtsuka, T., Nagai, E., Mizumoto, K., Hashizume, M. & Nakamura, M., Feb 2017, In : International journal of oncology. 50, 2, p. 457-467 11 p.

Research output: Contribution to journalArticle

Carotid body denervation markedly improves survival in rats with hypertensive heart failure

Fujii, K., Saku, K., Kishi, T., Oga, Y., Tohyama, T., Nishikawa, T., Sakamoto, T., Ikeda, M., Ide, T., Tsutsui, H. & Sunagawa, K., Jan 1 2017, In : American Journal of Hypertension. 30, 8, p. 791-798 8 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

CD24 modulates chemosensitivity of MCF-7 breast cancer cells

Onishi, H., Suyama, K., Yamasaki, A., Oyama, Y., Fujimura, A., Kawamoto, M. & Imaizumi, A., Jan 1 2017, In : Anticancer research. 37, 2, p. 561-566 6 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Central chemoreflex activation induces sympatho-excitation without altering static or dynamic baroreflex function in normal rats

Saku, K., Tohyama, T., Shinoda, M., Kishi, T., Hosokawa, K., Nishikawa, T., Oga, Y., Sakamoto, T., Tsutsui, H., Miyamoto, T. & Sunagawa, K., Sep 12 2017, In : Physiological Reports. 5, 17, e13406.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Characteristic systolic waveform of left ventricular longitudinal strain rate in patients with hypertrophic cardiomyopathy

Okada, K., Kaga, S., Mikami, T., Masauzi, N., Abe, A., Nakabachi, M., Yokoyama, S., Nishino, H., Ichikawa, A., Nishida, M., Murai, D., Hayashi, T., Shimizu, C., Iwano, H., Yamada, S. & Tsutsui, H., May 1 2017, In : Heart and Vessels. 32, 5, p. 591-599 9 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Chd2 regulates chromatin for proper gene expression toward differentiation in mouse embryonic stem cells

Semba, Y., Harada, A., Maehara, K., Oki, S., Meno, C., Ueda, J., Yamagata, K., Suzuki, A., Onimaru, M., Nogami, J., Okada, S., Akashi, K. & Ohkawa, Y., Sep 1 2017, In : Nucleic acids research. 45, 15, p. 8758-8772 15 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Clinical characteristics of type A acute aortic dissection with CNS symptom

Shono, Y., Akahoshi, T., Mezuki, S., Momii, K., Kaku, N., Maki, J., Tokuda, K., Ago, T., Kitazono, T. & Maehara, Y., Dec 2017, In : American Journal of Emergency Medicine. 35, 12, p. 1836-1838 3 p.

Research output: Contribution to journalArticle

Clinical features and surgical management of rare cases of thoracic intraspinal cysts: Report of 3 cases

Saiwai, H., Okada, S., Miyazaki, K., Nakano, R., Iwamoto, Y. & Tsuchiya, K., May 1 2017, In : Journal of Orthopaedic Science. 22, 3, p. 578-582 5 p.

Research output: Contribution to journalArticle

Comparison of weighed food record procedures for the reference methods in two validation studies of food frequency questionnaires

Ishii, Y., Ishihara, J., Takachi, R., Shinozawac, Y., Imaeda, N., Goto, C., Wakai, K., Takahashi, T., Iso, H., Nakamura, K., Tanaka, J., Shimazu, T., Yamaji, T., Sasazuki, S., Sawada, N., Iwasaki, M., Mikami, H., Kuriki, K., Naito, M., Okamoto, N. & 13 others, Kondo, F., Hosono, S., Miyagawa, N., Ozaki, E., Katsuura-Kamano, S., Ohnaka, K., Nanri, H., Tsunematsu-Nakahata, N., Kayama, T., Kurihara, A., Kojima, S., Tanaka, H. & Tsugane, S., Jan 1 2017, In : Journal of epidemiology. 27, 7, p. 331-337 7 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Delayed contrast-enhanced computed tomography in patients with known or suspected cardiac sarcoidosis: A feasibility study

Aikawa, T., Oyama-Manabe, N., Naya, M., Ohira, H., Sugimoto, A., Tsujino, I., Obara, M., Manabe, O., Kudo, K., Tsutsui, H. & Tamaki, N., Oct 1 2017, In : European Radiology. 27, 10, p. 4054-4063 10 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Development of holistic cancer treatment centering cancer patients-from the standpoint of hypoxia and hedgehog signaling

Onishi, H., Ogino, T., Morisaki, T. & Katano, M., Nov 2017, In : Japanese Journal of Cancer and Chemotherapy. 44, 11, p. 977-980 4 p.

Research output: Contribution to journalArticle

Diagnosis and treatment guidelines for aberrant portal hemodynamics: The Aberrant Portal Hemodynamics Study Group supported by the Ministry of Health, Labor and Welfare of Japan

Working Subgroup for Clinical Practice Guideline for Aberrant Portal Hemodynamics *,**, Apr 2017, In : Hepatology Research. 47, 5, p. 373-386 14 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Effect modification of green tea on the association between rice intake and the risk of diabetes mellitus: A prospective study in Japanese men and women

Hirata, A., Ohnaka, K., Tashiro, N., Wang, Z., Kohno, M., Kiyohara, C., Kono, S. & Takayanagi, R., May 1 2017, In : Asia Pacific Journal of Clinical Nutrition. 26, 3, p. 545-555 11 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
23 Citations (Scopus)

Efficacy and safety of sacubitril/valsartan (LCZ696) in Japanese patients with chronic heart failure and reduced ejection fraction: Rationale for and design of the randomized, double-blind PARALLEL-HF study

Tsutsui, H., Momomura, S., Saito, Y., Ito, H., Yamamoto, K., Ohishi, T., Okino, N. & Guo, W., Sep 2017, In : Journal of Cardiology. 70, 3, p. 225-231 7 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Esophageal perforation due to blunt chest trauma: Difficult diagnosis because of coexisting severe disturbance of consciousness

Mezuki, S., Shono, Y., Akahoshi, T., Hisanaga, K., Saeki, H., Nakashima, Y., Momii, K., Maki, J., Tokuda, K. & Maehara, Y., Nov 2017, In : American Journal of Emergency Medicine. 35, 11, p. 1790.e3-1790.e5

Research output: Contribution to journalArticle

1 Citation (Scopus)

Evaluating the Efficacy, Safety, and Tolerability of Serelaxin When Added to Standard Therapy in Asian Patients With Acute Heart Failure: Design and Rationale of RELAX-AHF-ASIA Trial

Sato, N., Lam, C. S. P., Teerlink, J. R., Greenberg, B. H., Tsutsui, H., Oh, B. H., Zhang, J., Lefkowitz, M., Hua, T. A., Holbro, T., Marshood, M., Wang, X. L. & Ge, J., Jan 1 2017, In : Journal of Cardiac Failure. 23, 1, p. 63-71 9 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
3 Citations (Scopus)

Experimental mouse model of lumbar ligamentum flavum hypertrophy

Saito, T., Yokota, K., Kobayakawa, K., Hara, M., Kubota, K., Harimaya, K., Kawaguchi, K., Hayashida, M., Matsumoto, Y., Doi, T., Shiba, K., Nakashima, Y. & Okada, S., Jan 2017, In : PloS one. 12, 1, e0169717.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Extra-pancreatic invasion induces lipolytic and fibrotic changes in the adipose microenvironment, with released fatty acids enhancing the invasiveness of pancreatic cancer cells

Okumura, T., Ohuchida, K., Sada, M., Abe, T., Endo, S., Koikawa, K., Iwamoto, C., Miura, D., Mizuuchi, Y., Moriyama, T., Nakata, K., Miyasaka, Y., Manabe, T., Ohtsuka, T., Nagai, E., Mizumoto, K., Oda, Y., Hashizume, M. & Nakamura, M., Jan 1 2017, In : Oncotarget. 8, 11, p. 18280-18295 16 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Ezetimibe in combination with statins ameliorates endothelial dysfunction in coronary arteries after stenting: the CuVIC trial (effect of cholesterol absorption inhibitor usage on target vessel dysfunction after coronary stenting), a multicenter randomized controlled trial

Takase, S., Matoba, T., Nakashiro, S., Mukai, Y., Inoue, S., Oi, K., Higo, T., Katsuki, S., Takemoto, M., Suematsu, N., Eshima, K., Miyata, K., Yamamoto, M., Usui, M., Sadamatsu, K., Satoh, S., Kadokami, T., Hironaga, K., Ichi, I., Todaka, K. & 3 others, Kishimoto, J., Egashira, K. & Sunagawa, K., Feb 2017, In : Arteriosclerosis, thrombosis, and vascular biology. 37, 2, p. 350-358 9 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Factors associated with the outcome of out-of-hospital cardiopulmonary arrest among people over 80 years old in Japan

Nagata, T., Abe, T., Hasegawa, M. & Hagihara, A., Apr 1 2017, In : Resuscitation. 113, p. 63-69 7 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

First Successful Pre-Distribution of Stable Iodine Tablets under Japan's New Policy after the Fukushima Daiichi Nuclear Accident

Ojino, M., Yoshida, S., Nagata, T., Ishii, M. & Akashi, M., Jun 1 2017, In : Disaster Medicine and Public Health Preparedness. 11, 3, p. 365-369 5 p.

Research output: Contribution to journalArticle

Functional loss of DHRS7C induces intracellular ca2+ overload and myotube enlargement in C2C12 cells via calpain activation

Arai, S., Ikeda, M., Ide, T., Matsuo, Y., Fujino, T., Hirano, K., Sunagawa, K. & Tsutsui, H., Jan 1 2017, In : American Journal of Physiology - Cell Physiology. 312, 1, p. C29-C39

Research output: Contribution to journalArticle

3 Citations (Scopus)

Future prospect of gallbladder therapy using Hedgehog signaling inhibitor

Onishi, H., Jan 1 2017, In : Chinese Clinical Oncology. 6, 1, 11.

Research output: Contribution to journalArticle

Genome-wide DNA methylation analysis reveals hypomethylation in the low-CpG promoter regions in lymphoblastoid cell lines

Taniguchi, I., Iwaya, C., Ohnaka, K., Shibata, H. & Yamamoto, K., Mar 4 2017, In : Human Genomics. 11, 1, 8.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Geometrical characteristics of aortic root and left ventricular dysfunction in aortic stenosis: quantification of 256-slice coronary CT angiography

Nagao, M., Yamasaki, Y., Kamitani, T., Kawanami, S., Kondo, M., Sonoda, H., Fujioka, T. & Honda, H., May 1 2017, In : Heart and Vessels. 32, 5, p. 558-565 8 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Hedgehog inhibition upregulates TRK expression to antagonize tumor suppression in small cell lung cancer cells

Onishi, H., Nakamura, K., Nagai, S., Yanai, K., Yamasaki, A., Kawamoto, M., Imaizumi, A. & Morisaki, T., Sep 2017, In : Anticancer research. 37, 9, p. 4987-4992 6 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Immunohistochemical identification of Propionibacterium acnes in granuloma and inflammatory cells of myocardial tissues obtained from cardiac sarcoidosis patients

Asakawa, N., Uchida, K., Sakakibara, M., Omote, K., Noguchi, K., Tokuda, Y., Kamiya, K., Hatanaka, K. C., Matsuno, Y., Yamada, S., Asakawa, K., Fukasawa, Y., Nagai, T., Anzai, T., Ikeda, Y., Ishibashi-Ueda, H., Hirota, M., Orii, M., Akasaka, T., Uto, K. & 5 others, Shingu, Y., Matsui, Y., Morimoto, S. I., Tsutsui, H. & Eishi, Y., Jul 2017, In : PloS one. 12, 7, e0179980.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Improving the strength of sutureless laser-assisted vessel repair using preloaded longitudinal compression on tissue edge

Nakadate, R., Omori, S., Ikeda, T., Akahoshi, T., Oguri, S., Arata, J., Onogi, S. & Hashizume, M., Jul 2017, In : Lasers in Surgery and Medicine. 49, 5, p. 533-538 6 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Influence of myopotential interference on the Wavelet discrimination algorithm in implantable cardioverter-defibrillator

Mizukami, K., Yokoshiki, H., Mitsuyama, H., Watanabe, M., Tenma, T., Kamada, R., Takahashi, M., Sasaki, R., Maeno, M. & Tsutsui, H., Jun 2017, In : journal of arrhythmia. 33, 3, p. 214-219 6 p.

Research output: Contribution to journalArticle

Inhibition of nitric oxide synthase unmasks vigorous vasoconstriction in established pulmonary arterial hypertension

Tanaka, M., Abe, K., Oka, M., Saku, K., Yoshida, K., Ishikawa, T., McMurtry, I. F., Sunagawa, K., Hoka, S. & Tsutsui, H., Dec 2017, In : Physiological Reports. 5, 23, e13537.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Interaction of reactive astrocytes with type i collagen induces astrocytic scar formation through the integrin-N-cadherin pathway after spinal cord injury

Hara, M., Kobayakawa, K., Ohkawa, Y., Kumamaru, H., Yokota, K., Saito, T., Kijima, K., Yoshizaki, S., Harimaya, K., Nakashima, Y. & Okada, S., Jul 1 2017, In : Nature medicine. 23, 7, p. 818-828 11 p.

Research output: Contribution to journalArticle

85 Citations (Scopus)

Intravenous electrical vagal nerve stimulation prior to coronary reperfusion in a canine ischemia-reperfusion model markedly reduces infarct size and prevents subsequent heart failure

Arimura, T., Saku, K., Kakino, T., Nishikawa, T., Tohyama, T., Sakamoto, T., Sakamoto, K., Kishi, T., Ide, T. & Sunagawa, K., Jan 15 2017, In : International Journal of Cardiology. 227, p. 704-710 7 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

In vivo redox metabolic imaging of mitochondria assesses disease progression in non-alcoholic steatohepatitis

Nakata, R., Hyodo, F., Murata, M., Eto, H., Nakaji, T., Kawano, T., Narahara, S., Yasukawa, K., Akahoshi, T., Tomikawa, M. & Hashizume, M., Dec 1 2017, In : Scientific reports. 7, 1, 17170.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Isolated ACTH deficiency probably induced by autoimmune-related mechanism evoked with nivolumab

Kitajima, K., Ashida, K., Wada, N., Suetsugu, R., Takeichi, Y., Sakamoto, S., Uchi, H., Matsushima, T., Shiratsuchi, M., Ohnaka, K., Furue, M. & Nomura, M., May 1 2017, In : Japanese journal of clinical oncology. 47, 5, p. 463-466 4 p., hyx018.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Liprin-α4 as a possible new therapeutic target for pancreatic cancer

Yamasaki, A., Nakayama, K., Imaizumi, A., Kawamoto, M., Fujimura, A., Oyama, Y., Nagai, S., Yanai, K. & Onishi, H., Jan 1 2017, In : Anticancer research. 37, 12, p. 6649-6654 6 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Macronutrient intakes and serum oestrogen, and interaction with polymorphisms in CYP19A1 and HSD17B1 genes: A cross-sectional study in postmenopausal Japanese women

Takagi, S., Naito, M., Kawai, S., Okada, R., Nagata, C., Hosono, S., Nishida, Y., Takashima, N., Suzuki, S., Shimoshikiryo, I., Mikami, H., Uemura, H., Kuriyama, N., Ohnaka, K., Kubo, M., Hamajima, N., Tanaka, H. & Wakai, K., Sep 28 2017, In : British Journal of Nutrition. 118, 6, p. 463-472 10 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Macrophage Infiltration Is a Causative Factor for Ligamentum Flavum Hypertrophy through the Activation of Collagen Production in Fibroblasts

Saito, T., Hara, M., Kumamaru, H., Kobayakawa, K., Yokota, K., Kijima, K., Yoshizaki, S., Harimaya, K., Matsumoto, Y., Kawaguchi, K., Hayashida, M., Inagaki, Y., Shiba, K., Nakashima, Y. & Okada, S., Dec 2017, In : American Journal of Pathology. 187, 12, p. 2831-2840 10 p.

Research output: Contribution to journalArticle

Matrix metalloproteinase 9 gene polymorphisms are associated with a multiple family history of gastric cancer

The Japan Multi-institutional Collaborative Cohort Study Group, Mar 1 2017, In : Gastric Cancer. 20, 2, p. 246-253 8 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
1 Citation (Scopus)

Novel imaging using a touchless display for computer-assisted hepato-biliary surgery

Oshiro, Y., Ohuchida, K., Okada, T., Hashizume, M. & Ohkohchi, N., Dec 1 2017, In : Surgery today. 47, 12, p. 1512-1518 7 p.

Research output: Contribution to journalArticle

Periostin Promotes Scar Formation through the Interaction between Pericytes and Infiltrating Monocytes/Macrophages after Spinal Cord Injury

Yokota, K., Kobayakawa, K., Saito, T., Hara, M., Kijima, K., Ohkawa, Y., Harada, A., Okazaki, K., Ishihara, K., Yoshida, S., Kudo, A., Iwamoto, Y. & Okada, S., Mar 1 2017, In : American Journal of Pathology. 187, 3, p. 639-653 15 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Prediction of hemodynamics under left ventricular assist device

Kakino, T., Saku, K., Sakamoto, T., Sakamoto, K., Akashi, T., Ikeda, M., Ide, T., Kishi, T., Tsutsui, H. & Sunagawa, K., Jan 1 2017, In : American Journal of Physiology - Heart and Circulatory Physiology. 312, 1, p. H80-H88

Research output: Contribution to journalArticle

3 Citations (Scopus)

Quantification of myocardial oxygenation in heart failure using blood-oxygen-level-dependent T2* magnetic resonance imaging: Comparison with cardiopulmonary exercise test

Nagao, M., Yamasaki, Y., Kawanami, S., Kamitani, T., Sagiyama, K., Higo, T., Ide, T., Takemura, A., Ishizaki, U., Fukushima, K., Watanabe, Y. & Honda, H., Jun 1 2017, In : Magnetic Resonance Imaging. 39, p. 138-143 6 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Regulation of RhoA by STAT3 coordinates glial scar formation

Renault-Mihara, F., Mukaino, M., Shinozaki, M., Kumamaru, H., Kawase, S., Baudoux, M., Ishibashi, T., Kawabata, S., Nishiyama, Y., Sugai, K., Yasutake, K., Okada, S., Nakamura, M. & Okano, H., Jan 1 2017, In : Journal of Cell Biology. 216, 8, p. 2533-2550 18 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Relationships of left ventricular strain and strain rate to wall stress and their afterload dependency

Murai, D., Yamada, S., Hayashi, T., Okada, K., Nishino, H., Nakabachi, M., Yokoyama, S., Abe, A., Ichikawa, A., Ono, K., Kaga, S., Iwano, H., Mikami, T. & Tsutsui, H., May 1 2017, In : Heart and Vessels. 32, 5, p. 574-583 10 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Resuscitation outcomes of reproductive-age females who experienced out-of-hospital cardiac arrest

Hagihara, A., Onozuka, D., Hasegawa, M., Nagata, T., Abe, T. & Nabeshima, Y., Mar 1 2017, In : European heart journal. Acute cardiovascular care. 6, 2, p. 121-129 9 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
1 Citation (Scopus)