Department of Advanced Medical Initiatives

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Beneficial compaction of spinal cord lesion by migrating astrocytes through glycogen synthase kinase-3 inhibition

Renault-Mihara, F., Katoh, H., Ikegami, T., Iwanami, A., Mukaino, M., Yasuda, A., Nori, S., Mabuchi, Y., Tada, H., Shibata, S., Saito, K., Matsushita, M., Kaibuchi, K., Okada, S., Toyama, Y., Nakamura, M. & Okano, H., Nov 1 2011, In : EMBO Molecular Medicine. 3, 11, p. 682-696 15 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

Beneficial effects of 3-dimensional visualization on hepatic vein reconstruction in living donor liver transplantation using right lobe graft

Hiroshige, S., Nishizaki, T., Soejima, Y., Hashimoto, K., Ohta, R., Minagawa, R., Shimada, M., Honda, H., Hashizume, M. & Sugimachi, K., Jan 1 2001, In : Transplantation. 72, 12, p. 1993-1996 4 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Big endothelin analogues with inhibitory activity on endothelin-converting enzyme-1

Takayanagi, R., Liu, W., Ito, T., Ohnaka, K. & Nawata, H., Jan 1 1998, In : Journal of Cardiovascular Pharmacology. 31, SUPPL. 1, p. S62-S63

Research output: Contribution to journalArticle

1 Citation (Scopus)

Bioluminescent system for dynamic imaging of cell and animal behavior

Hara-Miyauchi, C., Tsuji, O., Hanyu, A., Okada, S., Yasuda, A., Fukano, T., Akazawa, C., Nakamura, M., Imamura, T., Matsuzaki, Y., Okano, H. J., Miyawaki, A. & Okano, H., Mar 9 2012, In : Biochemical and Biophysical Research Communications. 419, 2, p. 188-193 6 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

Bionic baroreceptor corrects postural hypotension in rats with impaired baroreceptor

Hosokawa, K., Ide, T., Tobushi, T., Sakamoto, K., Onitsuka, K., Sakamoto, T., Fujino, T., Saku, K. & Sunagawa, K., Sep 4 2012, In : Circulation. 126, 10, p. 1278-1285 8 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Bleeding from gastric ulcer halted by laparoscopic suture ligation

Kitano, S., Kawanaka, H., Tomikawa, M., Hirabayashi, H., Hashizume, M. & Sugimachi, K., May 1 1994, In : Surgical endoscopy. 8, 5, p. 405-407 3 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Blockade of L-type Ca2+ channel attenuates doxorubicin-induced cardiomyopathy via suppression of CaMKII-NF-κB pathway

Ikeda, S., Matsushima, S., Okabe, K., Ikeda, M., Ishikita, A., Tadokoro, T., Enzan, N., Yamamoto, T., Sada, M., Deguchi, H., Morimoto, S., Ide, T. & Tsutsui, H., Dec 1 2019, In : Scientific reports. 9, 1, 9850.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Blockade of monocyte chemoattractant protein-1 by adenoviral gene transfer inhibits experimental vein graft neointimal formation

Tatewaki, H., Egashira, K., Kimura, S., Nishida, T., Morita, S. & Tominaga, R., Jun 1 2007, In : Journal of Vascular Surgery. 45, 6, p. 1236-1243 8 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

Blockade of NF-κB ameliorates myocardial hypertrophy in response to chronic infusion of angiotensin II

Kawano, S., Kubota, T., Monden, Y., Kawamura, N., Tsutsui, H., Takeshita, A. & Sunagawa, K., Sep 1 2005, In : Cardiovascular research. 67, 4, p. 689-698 10 p.

Research output: Contribution to journalArticle

79 Citations (Scopus)

Blockade of NF-κB improves cardiac function and survival without affecting inflammation in TNF-α-induced cardiomyopathy

Kawamura, N., Kubota, T., Kawano, S., Monden, Y., Feldman, A. M., Tsutsui, H., Takeshita, A. & Sunagawa, K., Jun 1 2005, In : Cardiovascular research. 66, 3, p. 520-529 10 p.

Research output: Contribution to journalArticle

80 Citations (Scopus)

Blood Pressure and hypertension are associated with 7 loci in the japanese population

Takeuchi, F., Isono, M., Katsuya, T., Yamamoto, K., Yokota, M., Sugiyama, T., Nabika, T., Fujioka, A., Ohnaka, K., Asano, H., Yamori, Y., Yamaguchi, S., Kobayashi, S., Takayanagi, R., Ogihara, T. & Kato, N., Jun 1 2010, In : Circulation. 121, 21, p. 2302-2309 8 p.

Research output: Contribution to journalArticle

130 Citations (Scopus)

Bone and soft tissue tumors presenting as sciatic notch dumbbell masses: A critical differential diagnosis of sciatica

Matsumoto, Y., Matsunobu, T., Harimaya, K., Kawaguchi, K., Hayashida, M., Okada, S., Doi, T. & Iwamoto, Y., Oct 10 2016, In : World Journal of Clinical Oncology. 7, 5, p. 414-419 6 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Brachial-ankle pulse wave velocity is an independent predictor of incident hypertension in Japanese normotensive male subjects

Satoh, H., Saijo, Y., Kishi, R. & Tsutsui, H., Jul 1 2011, In : Environmental health and preventive medicine. 16, 4, p. 217-223 7 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Bradykinin-induced vasodilation is impaired at the atherosclerotic site but is preserved at the spastic site of human coronary arteries in vivo

Kuga, T., Egashira, K., Mohri, M., Tsutsui, H., Harasawa, Y., Urabe, Y., Ando, S., Shimokawa, H. & Takeshita, A., Jul 15 1995, In : Circulation. 92, 2, p. 183-189 7 p.

Research output: Contribution to journalArticle

70 Citations (Scopus)

Brain-derived neurotrophic factor/tropomyosin-related kinase B signaling pathway contributes to the aggressive behavior of lung squamous cell carcinoma

Ozono, K., Ohishi, Y., Onishi, H., Nakamura, K., Motoshita, J., Kato, M., Nakanishi, R., Nakamura, M. & Oda, Y., Nov 1 2017, In : Laboratory Investigation. 97, 11, p. 1332-1342 11 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Brain perivascular macrophages contribute to the development of hypertension in stroke-prone spontaneously hypertensive rats via sympathetic activation

Iyonaga, T., Shinohara, K., Mastuura, T., Hirooka, Y. & Tsutsui, H., Feb 1 2020, In : Hypertension Research. 43, 2, p. 99-110 12 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Budd-Chiari syndrome and Epstein-Barr virus (EBV) associated plasmacytoma in a patient with chronic active EBV infection

Nagafuchi, S., Ishibashi, H., Anzai, K., Ohshima, K., Ohno, Y., Fukushima, N., Hashizume, M., Sugimachi, K., Chuman, H., Kikuchi, M. & Niho, Y., Nov 1 1994, In : The Clinical Investigator. 72, 11, p. 883-886 4 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Cadherin-11 regulates the metastasis of Ewing sarcoma cells to bone

Hatano, M., Matsumoto, Y., Fukushi, J. I., Matsunobu, T., Endo, M., Okada, S., Iura, K., Kamura, S., Fujiwara, T., Iida, K., Fujiwara, Y., Nabeshima, A., Yokoyama, N., Fukushima, S., Oda, Y. & Iwamoto, Y., Aug 25 2015, In : Clinical and Experimental Metastasis. 32, 6, p. 579-591 13 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Cancer-associated peritoneal mesothelial cells lead the formation of pancreatic cancer peritoneal dissemination

Abe, T., Ohuchida, K., Koikawa, K., Endo, S., Okumura, T., Sada, M., Horioka, K., Zheng, B., Moriyama, T., Nakata, K., Miyasaka, Y., Manabe, T., Ohtsuka, T., Nagai, E., Mizumoto, K., Hashizume, M. & Nakamura, M., Feb 2017, In : International journal of oncology. 50, 2, p. 457-467 11 p.

Research output: Contribution to journalArticle

Cardiac phase-targeted dynamic load on left ventricle differentially regulates phase-sensitive gene expressions and pathway activation

Onitsuka, K., Ide, T., Arai, S., Hata, Y., Murayama, Y., Hosokawa, K., Sakamoto, T., Tobushi, T., Sakamoto, K., Fujino, T. & Sunagawa, K., Nov 1 2013, In : Journal of Molecular and Cellular Cardiology. 64, p. 30-38 9 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Cardiac tamponade due to spontaneous rupture of large coronary artery aneurysm

Kimura, S., Miyamoto, K. & Ueno, Y., Oct 2006, In : Asian Cardiovascular and Thoracic Annals. 14, 5, p. 422-424 3 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Cardioprotective effect of renin–angiotensin inhibitors and β-blockers in trastuzumab-related cardiotoxicity

Ohtani, K., Ide, T., Hiasa, K. I., Sakamoto, I., Yamashita, N., Kubo, M. & Tsutsui, H., Oct 1 2019, In : Clinical Research in Cardiology. 108, 10, p. 1128-1139 12 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Cardiopulmonary arrest caused by acute abdominal aortic thrombosis: A case report

Matsuoka, Y. & Hashizume, M., Apr 28 2009, In : BMJ case reports.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Cardioscopy-guided surgery: Intracardiac mitral and tricuspid valve repair under direct visualization in the beating heart

Shiose, A., Takaseya, T., Fumoto, H., Horai, T., Kim, H. I., Fukamachi, K. & Mihaljevic, T., Jul 1 2011, In : Journal of Thoracic and Cardiovascular Surgery. 142, 1, p. 199-202 4 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Carotid body denervation markedly improves survival in rats with hypertensive heart failure

Fujii, K., Saku, K., Kishi, T., Oga, Y., Tohyama, T., Nishikawa, T., Sakamoto, T., Ikeda, M., Ide, T., Tsutsui, H. & Sunagawa, K., Jan 1 2017, In : American Journal of Hypertension. 30, 8, p. 791-798 8 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Catumaxomab with activated T-cells efficiently lyses chemoresistant EpCAM-positive triple-negative breast cancer cell lines

Kubo, M., Umebayashi, M., Kurata, K., Mori, H., Kai, M., Onishi, H., Katano, M., Nakamura, M. & Morisaki, T., Jul 2018, In : Anticancer research. 38, 7, p. 4273-4279 7 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

CD146 attenuation in cancer-associated fibroblasts promotes pancreatic cancer progression

Zheng, B., Ohuchida, K., Chijiiwa, Y., Zhao, M., Mizuuchi, Y., Cui, L., Horioka, K., Ohtsuka, T., Mizumoto, K., Oda, Y., Hashizume, M., Nakamura, M. & Tanaka, M., Nov 1 2016, In : Molecular Carcinogenesis. 55, 11, p. 1560-1572 13 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

CD24 modulates chemosensitivity of MCF-7 breast cancer cells

Onishi, H., Suyama, K., Yamasaki, A., Oyama, Y., Fujimura, A., Kawamoto, M. & Imaizumi, A., Jan 1 2017, In : Anticancer research. 37, 2, p. 561-566 6 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

CD24 suppresses malignant phenotype by downregulation of SHH transcription through STAT1 inhibition in breast cancer cells

Suyama, K., Onishi, H., Imaizumi, A., Shinkai, K., Umebayashi, M., Kubo, M., Mizuuchi, Y., Oda, Y., Tanaka, M., Nakamura, M. & Katano, M., Apr 28 2016, In : Cancer Letters. 374, 1, p. 44-53 10 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Central chemoreflex activation induces sympatho-excitation without altering static or dynamic baroreflex function in normal rats

Saku, K., Tohyama, T., Shinoda, M., Kishi, T., Hosokawa, K., Nishikawa, T., Oga, Y., Sakamoto, T., Tsutsui, H., Miyamoto, T. & Sunagawa, K., Sep 12 2017, In : Physiological Reports. 5, 17, e13406.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Changes in vascular properties, not ventricular properties, predominantly contribute to baroreflex regulation of arterial pressure

Sakamoto, T., Kakino, T., Sakamoto, K., Tobushi, T., Tanaka, A., Saku, K., Hosokawa, K., Onitsuka, K., Murayama, Y., Tsutsumi, T., Ide, T. & Sunagawa, K., Jan 1 2015, In : American Journal of Physiology - Heart and Circulatory Physiology. 308, 1, p. H49-H58

Research output: Contribution to journalArticle

20 Citations (Scopus)
1 Citation (Scopus)

Characteristics of splenic CD8+ T cell exhaustion in patients with hepatitis C

Sumida, K., Shimoda, S., Iwasaka, S., Hisamoto, S., Kawanaka, H., Akahoshi, T., Ikegami, T., Shirabe, K., Shimono, N., Maehara, Y., Selmi, C., Gershwin, M. E. & Akashi, K., Oct 1 2013, In : Clinical and Experimental Immunology. 174, 1, p. 172-178 7 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Chd2 interacts with H3.3 to determine myogenic cell fate

Harada, A., Okada, S., Konno, D., Odawara, J., Yoshimi, T., Yoshimura, S., Kumamaru, H., Saiwai, H., Tsubota, T., Kurumizaka, H., Akashi, K., Tachibana, T., Imbalzano, A. N. & Ohkawa, Y., Jul 4 2012, In : EMBO Journal. 31, 13, p. 2994-3007 14 p.

Research output: Contribution to journalArticle

68 Citations (Scopus)

Chd2 regulates chromatin for proper gene expression toward differentiation in mouse embryonic stem cells

Semba, Y., Harada, A., Maehara, K., Oki, S., Meno, C., Ueda, J., Yamagata, K., Suzuki, A., Onimaru, M., Nogami, J., Okada, S., Akashi, K. & Ohkawa, Y., Sep 1 2017, In : Nucleic acids research. 45, 15, p. 8758-8772 15 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Chronic colchicine administration attenuates cardiac hypertrophy in spontaneously hypertensive rats

Tsutsui, H., Ishibashi, Y., Takahashi, M., Namba, T., Tagawa, H., Imanaka-Yoshida, K. & Takeshita, A., Jan 1 1999, In : Journal of Molecular and Cellular Cardiology. 31, 6, p. 1203-1213 11 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Chronic kidney disease as an independent risk for long-term adverse outcomes in patients hospitalized with heart failure in Japan - Report from the Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD)

Hamaguchi, S., Tsuchihashi-Makaya, M., Kinugawa, S., Yokota, T., Ide, T., Takeshita, A. & Tsutsui, H., Aug 1 2009, In : Circulation Journal. 73, 8, p. 1442-1447 6 p.

Research output: Contribution to journalArticle

55 Citations (Scopus)

Cilostazol is useful for the treatment of sinus bradycardia and associated hemodynamic deterioration following heart transplantation

Uchikawa, T., Fujino, T., Higo, T., Ohtani, K., Shiose, A. & Tsutsui, H., Jan 1 2019, In : International heart journal. 60, 5, p. 1222-1225 4 p.

Research output: Contribution to journalArticle

Open Access

Cilostazol suppresses angiotensin II-induced vasoconstriction via protein kinase A-mediated phosphorylation of the transient receptor potential canonical 6 channel

Nishioka, K., Nishida, M., Ariyoshi, M., Jian, Z., Saiki, S., Hirano, M., Nakaya, M., Sato, Y., Kita, S., Iwamoto, T., Hirano, K., Inoue, R. & Kurose, H., Oct 1 2011, In : Arteriosclerosis, thrombosis, and vascular biology. 31, 10, p. 2278-2286 9 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Circulating vitamin D and colorectal adenomas in Japanese men

Takahashi, R., Mizoue, T., Otake, T., Fukumoto, J., Tajima, O., Tabata, S., Abe, H., Ohnaka, K. & Kono, S., Jul 1 2010, In : Cancer Science. 101, 7, p. 1695-1700 6 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Clinical and angiographic assessments and treatment of patients with recurrent varices after transabdominal transection of the esophagus

Ariyoshi, T., Hashizume, M., Kitano, S., Koyanagi, N. & Sugimachi, K., Mar 11 1997, In : Hepato-gastroenterology. 44, 13, p. 192-198 7 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Clinical characteristics and outcomes of dilated phase of hypertrophic cardiomyopathy: Report from the registry data in Japan

Goto, D., Kinugawa, S., Hamaguchi, S., Sakakibara, M., Tsuchihashi-Makaya, M., Yokota, T., Yamada, S., Yokoshiki, H. & Tsutsui, H., Jan 1 2013, In : Journal of Cardiology. 61, 1, p. 65-70 6 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Clinical characteristics and prognosis of hospitalized patients with congestive heart failure: A study in Fukuoka, Japan

Tsuchihashi, M., Tsutsui, H., Kodama, K., Kasagi, F. & Takeshita, A., Dec 27 2000, In : JAPANESE CIRCULATION JOURNAL. 64, 12, p. 953-959 7 p.

Research output: Contribution to journalArticle

59 Citations (Scopus)
24 Citations (Scopus)

Clinical characteristics of type A acute aortic dissection with CNS symptom

Shono, Y., Akahoshi, T., Mezuki, S., Momii, K., Kaku, N., Maki, J., Tokuda, K., Ago, T., Kitazono, T. & Maehara, Y., Dec 2017, In : American Journal of Emergency Medicine. 35, 12, p. 1836-1838 3 p.

Research output: Contribution to journalArticle

Clinical consequences of road traffic injuries among the elderly in Japan

Nagata, T., Uno, H. & Perry, M. J., Jul 1 2010, In : BMC Public Health. 10, 375.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Clinical features and surgical management of rare cases of thoracic intraspinal cysts: Report of 3 cases

Saiwai, H., Okada, S., Miyazaki, K., Nakano, R., Iwamoto, Y. & Tsuchiya, K., May 1 2017, In : Journal of Orthopaedic Science. 22, 3, p. 578-582 5 p.

Research output: Contribution to journalArticle

Clinical influence of cervical spinal canal stenosis on neurological outcome after traumatic cervical spinal cord injury without major fracture or dislocation

Takao, T., Okada, S., Morishita, Y., Maeda, T., Kubota, K., Ideta, R., Mori, E., Yugue, I., Kawano, O., Sakai, H., Ueta, T. & Shiba, K., Jan 1 2016, In : Asian Spine Journal. 10, 3, p. 536-542 7 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Clinical outcome and prognostic factors of malignant spinal dumbbell tumors

Matsumoto, Y., Kawaguchi, K., Fukushi, J. I., Endo, M., Setsu, N., Iida, K., Baba, S., Saiwai, H., Matsushita, A., Hayashida, M., Okada, S. & Nakashima, Y., Jan 1 2018, In : Spine Surgery and Related Research. 2, 4, p. 317-323 7 p.

Research output: Contribution to journalArticle

Open Access