Department of Advanced Medical Initiatives

Research Output 1980 2020

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Future prospect of gallbladder therapy using Hedgehog signaling inhibitor

Onishi, H., Jan 1 2017, In : Chinese Clinical Oncology. 6, 1, 11.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Gamma-secretase complexes regulate the responses of human pancreatic ductal adenocarcinoma cells to taxanes

Tasaka, T., Akiyoshi, T., Yamaguchi, K., Tanaka, M., Onishi, H. & Katano, M., Dec 1 2010, In : Anticancer research. 30, 12, p. 4999-5010 12 p.

Research output: Contribution to journalArticle

Taxoids
Amyloid Precursor Protein Secretases
Adenocarcinoma
Apoptosis
Presenilin-1
2 Citations (Scopus)

Gastric bleeding after endoscopic injection sclerotherapy for esophageal varices may be fatal

Higashi, H., Kitano, S., Hashizume, M., Yamaga, H., Wada, H. & Sugimachi, K., Jan 1 1991, In : International Surgery. 76, 4, p. 214-217 4 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Gastric endoscopic submucosal dissection using novel 26-mm articulating devices: an ex vivo comparative and in vivo feasibility study

Nakadate, R., Nakamura, S., Moriyama, T., Kenmotsu, H., Oguri, S., Arata, J., Uemura, M., Ohuchida, K., Akahoshi, T., Ikeda, T. & Hashizume, M., Sep 1 2015, In : Endoscopy. 47, 9, p. 820-824 5 p.

Research output: Contribution to journalArticle

Feasibility Studies
Stomach
Equipment and Supplies
Dissection
Endoscopes

Gastroenterological Surgery: Pancreas

Tanaka, M., Tomikawa, M., Nakamura, M., Nakamura, Y., Misawa, T., Akahoshi, T., Kinjyo, N., Sumiyoshi, H., Tsutsumi, K., Tsutsumi, N., Nakashima, H., Higashida, M., Fujiwara, Y., Matsushita, A. & Matsumoto, M., Aug 1 2015, In : Asian journal of endoscopic surgery. 8, 3, p. 239-242 4 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Gemcitabine synergistically enhances the effect of adenovirus gene therapy through activation of the CMV promoter in pancreatic cancer cells

Onimaru, M., Ohuchida, K., Egami, T., Mizumoto, K., Nagai, E., Cui, L., Toma, H., Matsumoto, K., Hashizume, M. & Tanaka, M., Aug 1 2010, In : Cancer Gene Therapy. 17, 8, p. 541-549 9 p.

Research output: Contribution to journalArticle

gemcitabine
Pancreatic Neoplasms
Adenoviridae
Genetic Therapy
Galactosidases
6 Citations (Scopus)

Gene-gene combination effect and interactions among ABCA1, APOA1, SR-B1, and CETP polymorphisms for serum high-density lipoprotein-cholesterol in the japanese population

Nakamura, A., Niimura, H., Kuwabara, K., Takezaki, T., Morita, E., Wakai, K., Hamajima, N., Nishida, Y., Turin, T. C., Suzuki, S., Ohnaka, K., Uemura, H., Ozaki, E., Hosono, S., Mikami, H., Kubo, M. & Tanaka, H., Dec 20 2013, In : PloS one. 8, 12, e82046.

Research output: Contribution to journalArticle

Polymorphism
high density lipoprotein cholesterol
HDL Cholesterol
Genes
genetic polymorphism
4 Citations (Scopus)

Generation of a rat monoclonal antibody specific for Hsp72

Tanaka, M., Shiota, M., Okada, S., Harada, A., Odawara, J., Mun, S., Iwao, H. & Ohkawa, Y., Aug 1 2011, In : Hybridoma. 30, 4, p. 397-400 4 p.

Research output: Contribution to journalArticle

HSP70 Heat-Shock Proteins
Monoclonal Antibodies
Cytoplasm
Heat-Shock Response
Proteins
10 Citations (Scopus)

Genetic impact on Uric acid concentration and hyperuricemia in the Japanese population

Takeuchi, F., Yamamoto, K., Isono, M., Katsuya, T., Akiyama, K., Ohnaka, K., Rakugi, H., Yamori, Y., Ogihara, T., Takayanagi, R. & Kato, N., May 3 2013, In : Journal of atherosclerosis and thrombosis. 20, 4, p. 351-367 17 p.

Research output: Contribution to journalArticle

Hyperuricemia
Uric Acid
Population
Polymorphism
Single Nucleotide Polymorphism
33 Citations (Scopus)

Genetic polymorphisms of XRCC1, alcohol consumption, and the risk of colorectal cancer in Japan

Yin, G., Morita, M., Ohnaka, K., Toyomura, K., Hamajima, N., Mizoue, T., Ueki, T., Tanaka, M., Kakeji, Y., Maehara, Y., Okamura, T., Ikejiri, K., Futami, K., Yasunami, Y., Maekawa, T., Takenaka, K., Ichimiya, H. & Terasaka, R., Jan 12 2012, In : Journal of epidemiology. 22, 1, p. 64-71 8 p.

Research output: Contribution to journalArticle

Genetic Polymorphisms
Alcohol Drinking
Colorectal Neoplasms
Japan
X-Rays
6 Citations (Scopus)

Gene variants in PPARD and PPARGC1A are associated with timing of natural menopause in the general Japanese population

Uemura, H., Hiyoshi, M., Arisawa, K., Yamaguchi, M., Naito, M., Kawai, S., Hamajima, N., Matsuo, K., Taguchi, N., Takashima, N., Suzuki, S., Hirasada, K., Mikami, H., Ohnaka, K., Yoshikawa, A., Kubo, M. & Tanaka, H., Apr 1 2012, In : Maturitas. 71, 4, p. 369-375 7 p.

Research output: Contribution to journalArticle

Menopause
Hazards
Genes
Population
Peroxisome Proliferator-Activated Receptors
27 Citations (Scopus)

Genome-wide association studies in East Asians identify new loci for waist-hip ratio and waist circumference

Wen, W., Kato, N., Hwang, J. Y., Guo, X., Tabara, Y., Li, H., Dorajoo, R., Yang, X., Tsai, F. J., Li, S., Wu, Y., Wu, T., Kim, S., Guo, X., Liang, J., Shungin, D., Adair, L. S., Akiyama, K., Allison, M., Cai, Q. & 56 others, Chang, L. C., Chen, C. H., Chen, Y. T., Cho, Y. S., Choi, B. Y., Gao, Y., Go, M. J., Gu, D., Han, B. G., He, M., Hixson, J. E., Hu, Y., Huang, T., Isono, M., Jung, K. J., Kang, D., Kim, Y. J., Kita, Y., Lee, J., Lee, N. R., Lee, J., Wang, Y., Liu, J. J., Long, J., Moon, S., Nakamura, Y., Nakatochi, M., Ohnaka, K., Rao, D., Shi, J., Sull, J. W., Tan, A., Ueshima, H., Wu, C., Xiang, Y. B., Yamamoto, K., Yao, J., Ye, X., Yokota, M., Zhang, X., Zheng, Y., Qi, L., Rotter, J. I., Jee, S. H., Lin, D., Mohlke, K. L., He, J., Mo, Z., Wu, J. Y., Tai, E. S., Lin, X., Miki, T., Kim, B. J., Takeuchi, F., Zheng, W. & Shu, X. O., Jan 20 2016, In : Scientific reports. 6, 17985.

Research output: Contribution to journalArticle

Waist-Hip Ratio
Genome-Wide Association Study
Waist Circumference
Abdominal Obesity
Body Mass Index

Genome-wide association study between bone mineral density and SNPs in Japanese postmenopausal women

Ohnaka, K., Mar 1 2009, In : Japanese Journal of Geriatrics. 46, 2, p. 114-116 3 p.

Research output: Contribution to journalArticle

Postmenopausal Osteoporosis
Genome-Wide Association Study
Bone Density
Single Nucleotide Polymorphism
Cohort Studies
94 Citations (Scopus)

Genome-wide association study of coronary artery disease in the Japanese

Takeuchi, F., Yokota, M., Yamamoto, K., Nakashima, E., Katsuya, T., Asano, H., Isono, M., Nabika, T., Sugiyama, T., Fujioka, A., Awata, N., Ohnaka, K., Nakatochi, M., Kitajima, H., Rakugi, H., Nakamura, J., Ohkubo, T., Imai, Y., Shimamoto, K., Yamori, Y. & 5 others, Yamaguchi, S., Kobayashi, S., Takayanagi, R., Ogihara, T. & Kato, N., Mar 1 2012, In : European Journal of Human Genetics. 20, 3, p. 333-340 8 p.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Single Nucleotide Polymorphism
Coronary Artery Disease
Alleles
Myocardial Infarction
6 Citations (Scopus)

Genome-wide association study of genetic factors related to confectionery intake: Potential roles of the ADIPOQ gene

Wakai, K., Matsuo, K., Matsuda, F., Yamada, R., Takahashi, M., Kawaguchi, T., Yatabe, Y., Ito, H., Hosono, S., Tajima, K., Naito, M., Morita, E., Yin, G., Sakamoto, T., Takashima, N., Suzuki, S., Nakahata, N., Mikami, H., Ohnaka, K., Watanabe, Y. & 4 others, Arisawa, K., Kubo, M., Hamajima, N. & Tanaka, H., Nov 1 2013, In : Obesity. 21, 11, p. 2413-2419 7 p.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Single Nucleotide Polymorphism
Genes
Cancer Care Facilities
Adipokines
4 Citations (Scopus)

Genomewide association study of leisure-time exercise behavior in Japanese Adults

Hara, M., Hachiya, T., Sutoh, Y., Matsuo, K., Nishida, Y., Shimanoe, C., Tanaka, K., Shimizu, A., Ohnaka, K., Kawaguchi, T., Oze, I., Matsuda, F., Ito, H., Kawai, S., Hishida, A., Okada, R., Sasakabe, T., Hirata, A., Ibusuki, R., Nindita, Y. & 19 others, Furusyo, N., Ikezaki, H., Kuriyama, N., Ozaki, E., Mikami, H., Nakamura, Y., Suzuki, S., Hosono, A., Katsuura-Kamano, S., Arisawa, K., Kuriki, K., Endoh, K., Takashima, N., Kadota, A., Nakatochi, M., Momozawa, Y., Kubo, M., Naito, M. & Wakai, K., Dec 1 2018, In : Medicine and Science in Sports and Exercise. 50, 12, p. 2433-2441 9 p.

Research output: Contribution to journalArticle

Leisure Activities
Exercise
Single Nucleotide Polymorphism
Meta-Analysis
Linear Models
1 Citation (Scopus)

Genome-wide association study revealed novel loci which aggravate asymptomatic hyperuricaemia into gout

Kawamura, Y., Nakaoka, H., Nakayama, A., Okada, Y., Yamamoto, K., Higashino, T., Sakiyama, M., Shimizu, T., Ooyama, H., Ooyama, K., Nagase, M., Hidaka, Y., Shirahama, Y., Hosomichi, K., Nishida, Y., Shimoshikiryo, I., Hishida, A., Katsuura-Kamano, S., Shimizu, S., Kawaguchi, M. & 29 others, Uemura, H., Ibusuki, R., Hara, M., Naito, M., Takao, M., Nakajima, M., Iwasawa, S., Nakashima, H., Ohnaka, K., Nakamura, T., Stiburkova, B., Merriman, T. R., Nakatochi, M., Ichihara, S., Yokota, M., Takada, T., Saitoh, T., Kamatani, Y., Takahashi, A., Arisawa, K., Takezaki, T., Tanaka, K., Wakai, K., Kubo, M., Hosoya, T., Ichida, K., Inoue, I., Shinomiya, N. & Matsuo, H., Oct 1 2019, In : Annals of the Rheumatic Diseases. 78, 10, p. 1430-1437 8 p.

Research output: Contribution to journalArticle

Open Access
Gout
Genome-Wide Association Study
Genes
Uric Acid
Crystals
1 Citation (Scopus)

Genome-wide DNA methylation analysis reveals hypomethylation in the low-CpG promoter regions in lymphoblastoid cell lines

Taniguchi, I., Iwaya, C., Ohnaka, K., Shibata, H. & Yamamoto, K., Mar 4 2017, In : Human Genomics. 11, 1, 8.

Research output: Contribution to journalArticle

DNA Methylation
Genetic Promoter Regions
Methylation
Genome
Blood Cells
530 Citations (Scopus)

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility

Mahajan, A., Go, M. J., Zhang, W., Below, J. E., Gaulton, K. J., Ferreira, T., Horikoshi, M., Johnson, A. D., Ng, M. C. Y., Prokopenko, I., Saleheen, D., Wang, X., Zeggini, E., Abecasis, G. R., Adair, L. S., Almgren, P., Atalay, M., Aung, T., Baldassarre, D., Balkau, B. & 312 others, Bao, Y., Barnett, A. H., Barroso, I., Basit, A., Been, L. F., Beilby, J., Bell, G. I., Benediktsson, R., Bergman, R. N., OBoehm, B., Boerwinkle, E., Bonnycastle, L. L., Burtt, N., Cai, Q., Campbell, H., Carey, J., Cauchi, S., Caulfield, M., Chan, J. C. N., Chang, L. C., Chang, T. J., Chang, Y. C., Charpentier, G., Chen, C. H., Chen, H., Chen, Y. T., Chia, K. S., Chidambaram, M., Chines, P. S., Cho, N. H., Cho, Y. M., Chuang, L. M., Collins, F. S., Cornelis, M. C., Couper, D. J., Crenshaw, A. T., Van Dam, R. M., Danesh, J., Das, D., De Faire, U., Dedoussis, G., Deloukas, P., Dimas, A. S., Dina, C., Doney, A. S. F., Donnelly, P. J., Dorkhan, M., Van Duijn, C., Dupuis, J., Edkins, S., Elliott, P., Emilsson, V., Erbel, R., Eriksson, J. G., Escobedo, J., Esko, T., Eury, E., Florez, J. C., Fontanillas, P., Forouhi, N. G., Forsen, T., Fox, C., Fraser, R. M., Frayling, T. M., Froguel, P., Frossard, P., Gao, Y., Gertow, K., Gieger, C., Gigante, B., Grallert, H., Grant, G. B., Groop, L. C., Groves, C. J., Grundberg, E., Guiducci, C., Hamsten, A., Han, B. G., Hara, K., Hassanali, N., Hattersley, A. T., Hayward, C., Hedman, A. K., Herder, C., Hofman, A., Holmen, O. L., Hovingh, K., Hreidarsson, A. B., Hu, C., Hu, F. B., Hui, J., Humphries, S. E., Hunt, S. E., Hunter, D. J., Hveem, K., Hydrie, Z. I., Ikegami, H., Illig, T., Ingelsson, E., Islam, M., Isomaa, B., Jackson, A. U., Jafar, T., James, A., Jia, W., Jöckel, K. H., Jonsson, A., Jowett, J. B. M., Kadowaki, T., Kang, H. M., Kanoni, S., Kao, W. H. L., Kathiresan, S., Kato, N., Katulanda, P., Keinanen-Kiukaanniemi, S. M., Kelly, A. M., Khan, H., Khaw, K. T., Khor, C. C., Kim, H. L., Kim, S., Kim, Y. J., Kinnunen, L., Klopp, N., Kong, A., Korpi-Hyövälti, E., Kowlessur, S., Kraft, P., Kravic, J., Kristensen, M. M., Krithika, S., Kumar, A., Kumate, J., Kuusisto, J., Kwak, S. H., Laakso, M., Lagou, V., Lakka, T. A., Langenberg, C., Langford, C., Lawrence, R., Leander, K., Lee, J. M., Lee, N. R., Li, M., Li, X., Li, Y., Liang, J., Liju, S., Lim, W. Y., Lind, L., Lindgren, C. M., Lindholm, E., Liu, C. T., Liu, J. J., Lobbens, S., Long, J., Loos, R. J. F., Lu, W., Luan, J., Lyssenko, V., WMa, R. C., Maeda, S., Mägi, R., Männistö, S., Matthews, D. R., Meigs, J. B., Melander, O., Metspalu, A., Meyer, J., Mirza, G., Mihailov, E., Moebus, S., Mohan, V., Mohlke, K. L., Morris, A. D., WMühleisen, T., Müller-Nurasyid, M., Musk, B., Nakamura, J., Nakashima, E., Navarro, P., Ng, P. K., Nica, A. C., Nilsson, P. M., Njølstad, I., Nöthen, M. M., Ohnaka, K., Ong, T. H., Owen, K. R., Palmer, C. N. A., Pankow, J. S., Park, K. S., Parkin, M., Pechlivanis, S., Pedersen, N. L., Peltonen, L., Perry, J. R. B., Peters, A., Pinidiyapathirage, J. M., Platou, C. G. P., Potter, S., Price, J. F., Qi, L., Radha, V., Rallidis, L., Rasheed, A., Rathmann, W., Rauramaa, R., Raychaudhuri, S., Rayner, N. W., Rees, S. D., Rehnberg, E., Ripatti, S., Robertson, N., Roden, M., Rossin, E. J., Rudan, I., Rybin, D., Saaristo, T. E., Salomaa, V., Saltevo, J., Samuel, M., KSanghera, D., Saramies, J., Scott, J., Scott, L. J., Scott, R. A., Segrè, A. V., Sehmi, J., Sennblad, B., Shah, N., Shah, S., Shera, A. S., Shu, X. O., Shuldiner, A. R., Sigurosson, G., Sijbrands, E., Silveira, A., Sim, X., Sivapalaratnam, S., Small, K. S., So, W. Y., Stančáková, A., Stefansson, K., Steinbach, G., Steinthorsdottir, V., Stirrups, K., Strawbridge, R. J., Stringham, H. M., Sun, Q., Suo, C., Syvänen, A. C., Takayanagi, R., Takeuchi, F., Tay, W. T., Teslovich, T. M., Thorand, B., Thorleifsson, G., Thorsteinsdottir, U., Tikkanen, E., Trakalo, J., Tremoli, E., Trip, M. D., Tsai, F. J., Tuomi, T., Tuomilehto, J., Uitterlinden, A. G., Valladares-Salgado, A., Vedantam, S., Veglia, F., Voight, B. F., Wang, C., Wareham, N. J., Wennauer, R., Wickremasinghe, A. R., Wilsgaard, T., Wilson, J. F., Wiltshire, S., Winckler, W., Wong, T. Y., Wood, A. R., Wu, J. Y., Wu, Y., Yamamoto, K., Yamauchi, T., Yang, M., Yengo, L., Yokota, M., Young, R., Zabaneh, D., Zhang, F., Zhang, R., Zheng, W., Zimmet, P. Z., Altshuler, D., Bowden, D. W., Cho, Y. S., Cox, N. J., Cruz, M., Hanis, C. L., Kooner, J., Lee, J. Y., Seielstad, M., Teo, Y. Y., Boehnke, M., Parra, E. J., Chambers, J. C., Tai, E. S., McCarthy, M. I. & Morris, A. P., Mar 2014, In : Nature genetics. 46, 3, p. 234-244 11 p.

Research output: Contribution to journalArticle

Type 2 Diabetes Mellitus
Meta-Analysis
Genome
Genome-Wide Association Study
Single Nucleotide Polymorphism

Geographical differences and the national meeting effect in patients with out-of-hospital cardiac arrests: A JCS–ReSS study report

behalf of the Japanese Circulation Society Resuscitation Science Study (JCS-ReSS) Group, Dec 2 2019, In : International journal of environmental research and public health. 16, 24, 5130.

Research output: Contribution to journalArticle

Open Access
Out-of-Hospital Cardiac Arrest
Group Processes
Japan
Logistic Models
Resuscitation
2 Citations (Scopus)

Geometrical characteristics of aortic root and left ventricular dysfunction in aortic stenosis: quantification of 256-slice coronary CT angiography

Nagao, M., Yamasaki, Y., Kamitani, T., Kawanami, S., Kondo, M., Sonoda, H., Fujioka, T. & Honda, H., May 1 2017, In : Heart and Vessels. 32, 5, p. 558-565 8 p.

Research output: Contribution to journalArticle

Aortic Valve Stenosis
Left Ventricular Dysfunction
Coronary Angiography
ROC Curve
Left Ventricular Function
7 Citations (Scopus)

Geometrical characteristics of left ventricular dyssynchrony in advanced heart failure: Myocardial strain analysis by tagged MRI

Nagao, M., Yamasaki, Y., Yonezawa, M., Kamitani, T., Kawanami, S., Mukai, Y., Higo, T., Yabuuchi, H., Sunagawa, K. & Honda, H., Jan 1 2014, In : International heart journal. 55, 6, p. 512-518 7 p.

Research output: Contribution to journalArticle

Heart Failure
Cine Magnetic Resonance Imaging
Logistic Models
Regression Analysis
Blood Pressure
3 Citations (Scopus)

Geriatric patients presenting to the emergency department of a Japanese university hospital.

Ezaki, T., Yamada, T., Yasuda, M., Setoguchi, H., Noda, E., Kanna, T., Shiraishi, K., Zaitsu, A. & Hashizume, M., Sep 2006, In : Fukuoka igaku zasshi = Hukuoka acta medica. 97, 9, p. 269-276 8 p.

Research output: Contribution to journalArticle

Geriatrics
Hospital Emergency Service
Emergencies
Intrinsic Factor
Ambulatory Care Facilities
16 Citations (Scopus)

Giant bar-type esophageal varices not eradicated by repeated injection sclerotherapy

Hashizume, M., Tanoue, K., Kitano, S., Ohta, M. & Sugimachi, K., Jan 1 1991, In : Gastrointestinal endoscopy. 37, 2, p. 187-189 3 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Giant gastric varices after a left gastric venous caval shunt operation for esophageal varices: A case report

Saeki, H., Hashizume, M., Yanaga, K., Ohta, M., Kawanaka, H., Kishihara, F., Tsugawa, Y., Migo, S. & Sugimachi, K., Jul 22 1998, In : Hepato-gastroenterology. 45, 21, p. 700-704 5 p.

Research output: Contribution to journalArticle

Venae Cavae
Esophageal and Gastric Varices
Stomach
Veins
Theft
156 Citations (Scopus)

Glucocorticoid enhances the expression of dickkopf-1 in human osteoblasts: Novel mechanism of glucocorticoid-induced osteoporosis

Ohnaka, K., Taniguchi, H., Kawate, H., Nawata, H. & Takayanagi, R., May 21 2004, In : Biochemical and Biophysical Research Communications. 318, 1, p. 259-264 6 p.

Research output: Contribution to journalArticle

Osteoblasts
Dexamethasone
Glucocorticoids
Osteoporosis
Low Density Lipoprotein Receptor-Related Protein-5
165 Citations (Scopus)

Glucocorticoid suppresses the canonical Wnt signal in cultured human osteoblasts

Ohnaka, K., Tanabe, M., Kawate, H., Nawata, H. & Takayanagi, R., Apr 1 2005, In : Biochemical and Biophysical Research Communications. 329, 1, p. 177-181 5 p.

Research output: Contribution to journalArticle

TCF Transcription Factors
Osteoblasts
Dexamethasone
Glucocorticoids
Catenins
44 Citations (Scopus)

Gold nanoparticle-based colorimetric assay for cancer diagnosis

Kang, J. H., Asami, Y., Murata, M., Kitazaki, H., Sadanaga, N., Tokunaga, E., Shiotani, S., Okada, S., Maehara, Y., Niidome, T., Hashizume, M., Mori, T. & Katayama, Y., Apr 15 2010, In : Biosensors and Bioelectronics. 25, 8, p. 1869-1874 6 p.

Research output: Contribution to journalArticle

Gold
Nanoparticles
Assays
Protein Kinase C
Tissue

Grand Sumo Tournaments and Out-of-Hospital Cardiac Arrests in Tokyo

Hagihara, A., Onozuka, D., Hasegawa, M., Miyazaki, S. & Nagata, T., Jul 6 2018, In : Journal of the American Heart Association. 7, 14

Research output: Contribution to journalArticle

Out-of-Hospital Cardiac Arrest
Tokyo
Wrestling
Sports
Odds Ratio
23 Citations (Scopus)

Granular cell tumors of the breast: A report of two cases

Ohnishi, H., Nishihara, K., Tamae, K., Mitsuyama, S., Abe, R., Toyoshima, S. & Abe, E., Jan 1 1996, In : Surgery today. 26, 11, p. 929-932 4 p.

Research output: Contribution to journalArticle

Granular Cell Tumor
Breast
Radical Mastectomy
Mammography
Fine Needle Biopsy
190 Citations (Scopus)

Greater oxidative stress in healthy young men compared with premenopausal women

Ide, T., Tsutsui, H., Ohashi, N., Hayashidani, S., Suematsu, N., Tsuchihashi, M., Tamai, H. & Takeshita, A., Mar 23 2002, In : Arteriosclerosis, thrombosis, and vascular biology. 22, 3, p. 438-442 5 p.

Research output: Contribution to journalArticle

Oxidative Stress
Thiobarbituric Acid Reactive Substances
Vitamins
Hyperlipidemias
Vitamin E
46 Citations (Scopus)

Greater susceptibility of failing cardiac myocytes to oxygen free radical-mediated injury

Tsutsui, H., Ide, T., Hayashidani, S., Suematsu, N., Utsumi, H., Nakamura, R., Egashira, K. & Takeshita, A., Jan 1 2001, In : Cardiovascular research. 49, 1, p. 103-109 7 p.

Research output: Contribution to journalArticle

Cardiac Myocytes
Free Radicals
Reactive Oxygen Species
Heart Failure
Muscle Cells
163 Citations (Scopus)

Guía ESC 2016 sobre el diagnóstico y tratamiento de la insuficiencia cardiaca aguda y crónica

Translated title of the contribution: 2016 ESC guidelines for the diagnosis and treatment of acute and chronic heart failurePonikowski, AM. D. G. D. T. P., Voors, A. A., Anker, S. D., Bueno, H., Cleland, J. G. F., Coats, A. J. S., Falk, V., González-Juanatey, J. R., Harjola, V. P., Jankowska, E. A., Jessup, M., Linde, C., Nihoyannopoulos, P., Parissis, J. T., Pieske, B., Riley, J. P., Rosano, G. M. C., Ruilope, L. M., Ruschitzka, F., Rutten, F. H. & 43 others, van der Meer, P., Filippatos, R. D. D. G., McMurray, J. J. V., Aboyans, V., Achenbach, S., Agewall, S., Al-Attar, N., James Atherton, J., Bauersachs, J., Camm, A. J., Carerj, S., Ceconi, C., Coca, A., Elliott, P., Erol, Ç., Ezekowitz, J., Fernández-Golfín, C., Fitzsimons, D., Guazzi, M., Guenoun, M., Hasenfuss, G., Hindricks, G., Hoes, A. W., Iung, B., Jaarsma, T., Kirchhof, P., Knuuti, J., Kolh, P., Konstantinides, S., Lainscak, M., Lancellotti, P., Lip, G. Y. H., Maisano, F., Mueller, C., Petrie, M. C., Piepoli, M. F., Priori, S. G., Torbicki, A., Tsutsui, H., van Veldhuisen, D. J., Windecker, S., Yancy, C. & Zamorano, J. L., Dec 1 2016, In : Revista Espanola de Cardiologia. 69, 12, p. 1167.-1167.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Guidelines for heart disease screening in schools (JCS 2016/JSPCCS 2016) - Digest version

Japanese Circulation Society and the Japanese Society of Pediatric Cardiology and Cardiac Surgery of Joint Working Group, Jan 1 2018, In : Circulation Journal. 82, 9, p. 2385-2444 60 p.

Research output: Contribution to journalArticle

Open Access
Heart Diseases
Guidelines
6 Citations (Scopus)

Heart failure with reduced ejection fraction: comparison of patient characteristics and clinical outcomes within Asia and between Asia, Europe and the Americas

Dewan, P., Jhund, P. S., Shen, L., Petrie, M. C., Abraham, W. T., Atif Ali, M., Chen, C. H., Desai, A. S., Dickstein, K., Huang, J., Kiatchoosakun, S., Kim, K. S., Køber, L., Lai, W. T., Liao, Y., Mogensen, U. M., Oh, B. H., Packer, M., Rouleau, J. L., Shi, V. & 7 others, Sibulo, A. S., Solomon, S. D., Sritara, P., Swedberg, K., Tsutsui, H., Zile, M. R. & McMurray, J. J. V., May 2019, In : European Journal of Heart Failure. 21, 5, p. 577-587 11 p.

Research output: Contribution to journalArticle

Open Access
Heart Failure
North America
Philippines
China
Taiwan
10 Citations (Scopus)
ivabradine
Heart Rate
Placebos
Heart Failure
Phosphenes
21 Citations (Scopus)

Hedgehog Gli3 activator signal augments tumorigenicity of colorectal cancer via upregulation of adherence-related genes

Iwasaki, H., Nakano, K., Shinkai, K., Kunisawa, Y., Hirahashi, M., Oda, Y., Onishi, H. & Katano, M., Mar 1 2013, In : Cancer Science. 104, 3, p. 328-336 9 p.

Research output: Contribution to journalArticle

Hedgehogs
Colorectal Neoplasms
Up-Regulation
Genes
HT29 Cells
4 Citations (Scopus)

Hedgehog inhibition upregulates TRK expression to antagonize tumor suppression in small cell lung cancer cells

Onishi, H., Nakamura, K., Nagai, S., Yanai, K., Yamasaki, A., Kawamoto, M., Imaizumi, A. & Morisaki, T., Sep 2017, In : Anticancer research. 37, 9, p. 4987-4992 6 p.

Research output: Contribution to journalArticle

Small Cell Lung Carcinoma
Up-Regulation
Neoplasms
tropomyosin kinase
Small Interfering RNA
31 Citations (Scopus)

Hedgehog inhibitor decreases chemosensitivity to 5-fluorouracil and gemcitabine under hypoxic conditions in pancreatic cancer

Onishi, H., Morifuji, Y., Kai, M., Suyama, K., Iwasaki, H. & Katano, M., Jul 1 2012, In : Cancer Science. 103, 7, p. 1272-1279 8 p.

Research output: Contribution to journalArticle

gemcitabine
Pancreatic Neoplasms
Fluorouracil
S Phase
Adenocarcinoma
50 Citations (Scopus)

Hedgehog signaling pathway as a new therapeutic target in pancreatic cancer

Onishi, H. & Katano, M., 2014, In : World Journal of Gastroenterology. 20, 9, p. 2335-2342 8 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Therapeutics
Neoplastic Stem Cells
Morphogenesis
Neoplasms
33 Citations (Scopus)

Hedgehog signaling pathway is a potential therapeutic target for gallbladder cancer

Matsushita, S., Onishi, H., Nakano, K., Nagamatsu, I., Imaizumi, A., Hattori, M., Oda, Y., Tanaka, M. & Katano, M., Mar 2014, In : Cancer Science. 105, 3, p. 272-280 9 p.

Research output: Contribution to journalArticle

Gallbladder Neoplasms
Therapeutics
Gallbladder
Matrix Metalloproteinases
Neoplasms
57 Citations (Scopus)

Hedgehog signaling pathway mediates the progression of non-invasive breast cancer to invasive breast cancer

Souzaki, M., Kubo, M., Kai, M., Kameda, C., Tanaka, H., Taguchi, T., Tanaka, M., Onishi, H. & Katano, M., Feb 1 2011, In : Cancer Science. 102, 2, p. 373-381 9 p.

Research output: Contribution to journalArticle

Ductal Carcinoma
Carcinoma, Intraductal, Noninfiltrating
Breast Neoplasms
Breast Diseases
Estrogen Receptors
3 Citations (Scopus)

Hedgehog signaling regulates PDL-1 expression in cancer cells to induce anti-tumor activity by activated lymphocytes

Onishi, H., Fujimura, A., Oyama, Y., Yamasaki, A., Imaizumi, A., Kawamoto, M., Katano, M., Umebayashi, M. & Morisaki, T., Dec 1 2016, In : Cellular Immunology. 310, p. 199-204 6 p.

Research output: Contribution to journalArticle

Lymphocytes
Neoplasms
Lymphocyte Count
Neutralizing Antibodies
Cell Count
3 Citations (Scopus)
Ligamentum Flavum
Transforming Growth Factor beta
Hematoma
Vascular Endothelial Growth Factor A
Spine
9 Citations (Scopus)

Hemodynamic analysis of findings in patients with portal hypertension: Multicenter analysis in Japan

Aoki, H., Hasumi, A., Hashizume, M., Kato, H., Moriyasu, F. & Idezuki, Y., Dec 1 1995, In : Hepato-gastroenterology. 42, 6, p. 1030-1038 9 p.

Research output: Contribution to journalArticle

Portal Hypertension
Japan
Hemodynamics
Splenic Vein
Splenic Artery
18 Citations (Scopus)

Hemodynamic and morphological changes in the dog kidney after injection of 5% ethanolamine oleate into the superior vena cava

Wada, H., Hashizume, M., Yamaga, H., Kitano, S. & Sugimachi, K., Jan 1 1990, In : European Surgical Research. 22, 2, p. 63-70 8 p.

Research output: Contribution to journalArticle

Superior Vena Cava
Renal Circulation
Hemodynamics
Dogs
Kidney
35 Citations (Scopus)

Hemodynamic study of splenic artery aneurysm in portal hypertension

Ohta, M., Hashizume, M., Ueno, K., Tanoue, K., Sugimachi, K. & Hasuo, K., Jan 1 1994, In : Hepato-gastroenterology. 41, 2, p. 181-184 4 p.

Research output: Contribution to journalArticle

Splenic Artery
Portal Hypertension
Aneurysm
Hemodynamics
Ultrasonography
17 Citations (Scopus)

Hepatic metastasis after laparoscopic cholecystectomy for polypoid gallbladder cancer followed by radical surgery

Nishizaki, T., Matsumata, T., Hashizume, M., Maeda, T., Otsuka, K. & Sugimachi, K., Dec 1 1994, In : Surgical endoscopy. 8, 12, p. 1436-1438 3 p.

Research output: Contribution to journalArticle

Gallbladder Neoplasms
Laparoscopic Cholecystectomy
Gallbladder
Neoplasm Metastasis
Liver
2 Citations (Scopus)

Hepatic vein waveform and splenomegaly predict improvement of prothrombin time after splenectomy in hepatitis C virus-related cirrhotic patients

Kinjo, N., Nagao, Y., Akahoshi, T., Masahiro, K., Hashimoto, N., Uehara, H., Kawanaka, H., Tomikawa, M., Shirabe, K., Hashizume, M. & Maehara, Y., Sep 1 2013, In : Hepatology Research. 43, 9, p. 933-941 9 p.

Research output: Contribution to journalArticle

Hepatic Veins
Prothrombin Time
Splenomegaly
Splenectomy
Hepacivirus