Department of Advanced Medical Initiatives

Research Output 1980 2019

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2011
25 Citations (Scopus)

Modulation of CD4+ T cell responses following splenectomy in hepatitis C virus-related liver cirrhosis

Hashimoto, N., Shimoda, S., Kawanaka, H., Tsuneyama, K., uehara, H., Akahoshi, T., Kinjo, N., Taketomi, A., Shirabe, K., Akashi, K., Lleo, A., Ansari, A. A., Gershwin, M. E. & Maehara, Y., Aug 1 2011, In : Clinical and Experimental Immunology. 165, 2, p. 243-250 8 p.

Research output: Contribution to journalArticle

Splenectomy
Hepacivirus
Liver Cirrhosis
T-Lymphocytes
Thrombocytopenia
3 Citations (Scopus)

Nifedipine treatment reduces brain damage after transient focal ischemia, possibly through its antioxidative effects

Yamato, M., Shiba, T., Ide, T., Honda, Y., Yamada, K-I. & Tsutsui, H., Jul 1 2011, In : Hypertension Research. 34, 7, p. 840-845 6 p.

Research output: Contribution to journalArticle

Nifedipine
Ischemia
Middle Cerebral Artery Infarction
Brain
Brain Ischemia
38 Citations (Scopus)

Objective assessment of laparoscopic suturing skills using a motion-tracking system

Yamaguchi, S., Yoshida, D., Kenmotsu, H., Yasunaga, T., Konishi, K., Ieiri, S., Nakashima, H., Tanoue, K. & Hashizume, M., Jan 1 2011, In : Surgical Endoscopy. 25, 3, p. 771-775 5 p.

Research output: Contribution to journalArticle

Electromagnetic Phenomena
Surgical Instruments
Laparoscopy
Surgeons
Hand
12 Citations (Scopus)

Objective response with lapatinib in patients with meningitis carcinomatosa derived from HER2/HER1-negative breast cancer

Ohnishi, H., Morisaki, T., Nakafusa, Y., Nakashima, Y., Yokohata, K. & Katano, M., Dec 1 2011, In : International Journal of Clinical Oncology. 16, 6, p. 718-721 4 p.

Research output: Contribution to journalArticle

Meningitis
Breast Neoplasms
Neoplasm Metastasis
Skin
Brain
4 Citations (Scopus)

Persistent roles of signal transduction of platelet-derived growth factor B in genesis, growth, and anaplastic transformation of gliomas in an in-vivo serial transplantation model

Torisu, R., Suzuki, S., Masui, K., Yoshimoto, K., Mizoguchi, M., Hashizume, M., Canoll, P., Goldman, J. E., Sasaki, T. & Iwaki, T., Feb 1 2011, In : Brain tumor pathology. 28, 1, p. 33-42 10 p.

Research output: Contribution to journalArticle

Proto-Oncogene Proteins c-sis
Glioma
Signal Transduction
Transplantation
Growth
28 Citations (Scopus)

Profile of participants and genotype distributions of 108 polymorphisms in a cross-sectional study of associations of genotypes with lifestyle and clinical factors: A project in the Japan Multi-Institutional Collaborative Cohort (J-MICC) study

Wakai, K., Hamajima, N., Okada, R., Naito, M., Morita, E., Hishida, A., Kawai, S., Nishio, K., Yin, G., Asai, Y., Matsuo, K., Hosono, S., Ito, H., Watanabe, M., Kawase, T., Suzuki, T., Tajima, K., Tanaka, K., Higaki, Y., Hara, M. & 56 others, Imaizumi, T., Taguchi, N., Nakamura, K., Nanri, H., Sakamoto, T., Horita, M., Shinchi, K., Kita, Y., Turin, T. C., Rumana, N., Matsui, K., Miura, K., Ueshima, H., Takashima, N., Nakamura, Y., Suzuki, S., Ando, R., Hosono, A., Imaeda, N., Shibata, K., Goto, C., Hattori, N., Fukatsu, M., Yamada, T., Tokudome, S., Takezaki, T., Niimura, H., Hirasada, K., Nakamura, A., Tatebo, M., Ogawa, S., Tsunematsu, N., Chiba, S., Mikami, H., Kono, S., Keizo, O., Takayanagi, R., Watanabe, Y., Ozaki, E., Shigeta, M., Kuriyama, N., Yoshikawa, A., Matsui, D., Watanabe, I., Inoue, K., Ozasa, K., Mitani, S., Arisawa, K., Uemura, H., Hiyoshi, M., Takami, H., Yamaguchi, M., Nakamoto, M., Takeda, H., Kubo, M. & Tanaka, H., May 30 2011, In : Journal of epidemiology. 21, 3, p. 223-235 13 p.

Research output: Contribution to journalArticle

Gene Frequency
Life Style
Japan
Cohort Studies
Cross-Sectional Studies
6 Citations (Scopus)

Rationale and design of the Japanese Heart Failure Outpatients Disease Management and Cardiac Evaluation (J-HOMECARE)

Tsuchihashi-Makaya, M., Matsuo, H., Kakinoki, S., Takechi, S. & Tsutsui, H., Sep 1 2011, In : Journal of Cardiology. 58, 2, p. 165-172 8 p.

Research output: Contribution to journalArticle

Disease Management
Outpatients
Heart Failure
Anxiety
Quality of Life
12 Citations (Scopus)

Resveratrol, a phytoestrogen found in red wine, down-regulates protein S expression in HepG2 cells

Hiroto, Y., Tadokoro, K., Tsuda, T., Nakazono, E., Keizo, O., Takayanagi, R., Hamasaki, N. & Tsuda, H., Jan 1 2011, In : Thrombosis Research. 127, 1

Research output: Contribution to journalArticle

Phytoestrogens
Protein S
Hep G2 Cells
Wine
Down-Regulation
10 Citations (Scopus)

Roles of vascular endothelial growth factor and endothelial nitric oxide synthase during revascularization and regeneration after partial hepatectomy in a rat model

Yoshida, D., Akahoshi, T., Kawanaka, H., Yamaguchi, S., Kinjo, N., Taketomi, A., Tomikawa, M., Shirabe, K., Maehara, Y. & Hashizume, M., Dec 1 2011, In : Surgery Today. 41, 12, p. 1622-1629 8 p.

Research output: Contribution to journalArticle

Liver Regeneration
Nitric Oxide Synthase Type III
Hepatectomy
Vascular Endothelial Growth Factor A
Regeneration
12 Citations (Scopus)

Semi-quantitative evaluation of CD44 +/CD24 - tumor cell distribution in breast cancer tissue using a newly developed fluorescence immunohistochemical staining method

Kai, M., Ohnishi, H., Souzaki, M., Tanaka, H., Kubo, M., Tanaka, M. & Katano, M., Dec 1 2011, In : Cancer Science. 102, 12, p. 2132-2138 7 p.

Research output: Contribution to journalArticle

Fluorescence
Staining and Labeling
Breast Neoplasms
Neoplasms
Hedgehogs
8 Citations (Scopus)

Smad2 protein disruption in the central nervous system leads to aberrant cerebellar development and early postnatal ataxia in mice

Wang, L., Nomura, M., Goto, Y., Tanaka, K., Sakamoto, R., Abe, I., Sakamoto, S., Shibata, A., Enciso, P. L. M., Adachi, M., Keizo, O., Kawate, H. & Takayanagi, R., May 27 2011, In : Journal of Biological Chemistry. 286, 21, p. 18766-18774 9 p.

Research output: Contribution to journalArticle

Smad2 Protein
Neurology
Ataxia
Central Nervous System
Biological Phenomena
31 Citations (Scopus)

Soy food and isoflavone intake and colorectal cancer risk: The Fukuoka Colorectal Cancer Study

Budhathoki, S., Joshi, A. M., Keizo, O., Yin, G., Toyomura, K., Kono, S., Mibu, R., Tanaka, M., Kakeji, Y., Maehara, Y., Okamura, T., Ikejiri, K., Futami, K., Maekawa, T., Yasunami, Y., Takenaka, K., Ichimiya, H. & Terasaka, R., Feb 1 2011, In : Scandinavian Journal of Gastroenterology. 46, 2, p. 165-172 8 p.

Research output: Contribution to journalArticle

Soy Foods
Isoflavones
Colorectal Neoplasms
Eating
Confidence Intervals
3 Citations (Scopus)

Successful management of cryptococcosis of the bilateral adrenal glands and liver by unilateral adrenalectomy with antifungal agents: A case report

matsuda, Y., Kawate, H., Okishige, Y., Abe, I., Adachi, M., Keizo, O., Satoh, N., Inokuchi, J., Tatsugami, K., Naito, S., Nomura, M. & Takayanagi, R., Dec 14 2011, In : BMC Infectious Diseases. 11, 340.

Research output: Contribution to journalArticle

Cryptococcosis
Antifungal Agents
Adrenalectomy
Adrenal Glands
Liver
1 Citation (Scopus)

Successful surgical treatment for methicillin-resistant Staphylococcus aureus endocarditis on the ventricular rerouting patch after a Rastelli operation

Shiokawa, Y., Nakashima, A., Tanoue, Y. & Tominaga, R., Jul 1 2011, In : General thoracic and cardiovascular surgery. 59, 7, p. 483-484 2 p.

Research output: Contribution to journalArticle

Methicillin-Resistant Staphylococcus aureus
Endocarditis
Polyethylene Terephthalates
Lacerations
Pulmonary Artery
2 Citations (Scopus)

Successful treatment for hepatic encephalopathy aggravated by portal vein thrombosis with balloon-occluded retrograde transvenous obliteration

Hashimoto, N., Akahoshi, T., Shoji, T., Tomikawa, M., Tsutsumi, N., Yoshizumi, T., Taketomi, A., Shirabe, K. & Maehara, Y., May 1 2011, In : Case Reports in Gastroenterology. 5, 2, p. 366-371 6 p.

Research output: Contribution to journalArticle

Hepatic Encephalopathy
Portal Vein
Thrombosis
Inferior Vena Cava
Hyperammonemia

Surface EMG and heartbeat analysis preliminary results in surgical training: dry boxes and live tissue.

Bartolomeo, L., Lin, Z., Zecca, M., Sessa, S., Ishii, H., Xu, H., Uemura, M., Tomikawa, M., Hashizume, M. & Takanishi, A., Jan 1 2011, In : Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference. p. 1113-1116 4 p.

Research output: Contribution to journalArticle

Animals
Exercise
Tissue
Electromyography
Virtual reality
2 Citations (Scopus)

Surgical repair of an idiopathic pulmonary artery aneurysm

Shiokawa, Y., Ushijima, T., Oishi, Y. & Tominaga, R., Feb 1 2011, In : General Thoracic and Cardiovascular Surgery. 59, 2, p. 120-122 3 p.

Research output: Contribution to journalArticle

Pulmonary Artery
Aneurysm
Pathology
Systemic Vasculitis
Back Pain
19 Citations (Scopus)

The classification of mRNA expression levels by the phosphorylation state of RNAPII CTD based on a combined genome-wide approach

Odawara, J., Harada, A., Yoshimi, T., Maehara, K., Tachibana, T., Okada, S., Akashi, K. & Ohkawa, Y., Oct 20 2011, In : BMC Genomics. 12, 516.

Research output: Contribution to journalArticle

RNA Polymerase II
Phosphorylation
Genome
Messenger RNA
Genes
1 Citation (Scopus)

The clinical significance of urine diacetylspermine level as a tumor marker for lung cancer

Kato, M., Ohnishi, H., Suzuki, H., Tsuruta, N., Higuchi, K. & Katano, M., Dec 1 2011, In : Japanese Journal of Lung Cancer. 51, 7, p. 787-792 6 p.

Research output: Contribution to journalArticle

Tumor Biomarkers
Lung Neoplasms
Urine
Serum
Biomarkers
3 Citations (Scopus)

The orientation of orthopaedic metallic devices relative to the frequency-encoding gradient affects susceptibility artifacts: an experiment using open MR imaging.

Takeuchi, N., Mitsuyasu, H., Nakanishi, T., Nishimura, S., Shimoto, T., Higaki, H., Hashizume, M. & Iwamoto, Y., May 1 2011, In : Fukuoka igaku zasshi = Hukuoka acta medica. 102, 5, p. 185-194 10 p.

Research output: Contribution to journalArticle

Artifacts
Orthopedics
Equipment and Supplies
Stainless Steel
Titanium

The present status and the innovative future of biomedical engineering

Ohdaira, T. & Hashizume, M., Dec 14 2011, In : Transactions of Japanese Society for Medical and Biological Engineering. 49, 2, p. 378-380 3 p.

Research output: Contribution to journalArticle

Biomedical engineering
24 Citations (Scopus)

TP53 R72P and MDM2 SNP309 polymorphisms and colorectal cancer risk: The Fukuoka Colorectal Cancer Study

Joshi, A. M., Budhathoki, S., Keizo, O., Mibu, R., Tanaka, M., Kakeji, Y., Maehara, Y., Okamura, T., Ikejiri, K., Futami, K., Maekawa, T. & Yasunami, Y., Feb 1 2011, In : Japanese journal of clinical oncology. 41, 2, p. 232-238 7 p.

Research output: Contribution to journalArticle

Guanine
Proline
p53 Genes
Colorectal Neoplasms
Thymine
7 Citations (Scopus)

Transforming growth factor β1 contributes to the invasiveness of pancreatic ductal adenocarcinoma cells through the regulation of CD24 expression

Kitaura, Y., Chikazawa, N., Tasaka, T., nakano, K., Tanaka, M., Ohnishi, H. & Katano, M., Oct 1 2011, In : Pancreas. 40, 7, p. 1034-1042 9 p.

Research output: Contribution to journalArticle

Transforming Growth Factors
Adenocarcinoma
RNA Interference
5 Citations (Scopus)

Trauma center accessibility for road traffic injuries in Hanoi, Vietnam

Nagata, T., Takamori, A., Kimura, Y., Kimura, A., Hashizume, M. & Nakahara, S., Sep 30 2011, In : Journal of Trauma Management and Outcomes. 5, 1, 11.

Research output: Contribution to journalArticle

Vietnam
Trauma Centers
Wounds and Injuries
Motorcycles
Geographic Information Systems
4 Citations (Scopus)

Trends in the treatment outcomes for advanced colorectal cancer: An analysis at a single community hospital in Japan

Tomikawa, M., Korenaga, D., Akahoshi, T., Kohshi, K., Sugimachi, K., Ikeda, Y., Takenaka, K. & Maehara, Y., Jun 1 2011, In : Surgery today. 41, 6, p. 801-805 5 p.

Research output: Contribution to journalArticle

Community Hospital
Colorectal Neoplasms
Japan
Survival Rate
Leucovorin
40 Citations (Scopus)

TRPC3-mediated Ca2+ influx contributes to Rac1-mediated production of reactive oxygen species in MLP-deficient mouse hearts

Kitajima, N., Watanabe, K., Morimoto, S., Sato, Y., Kiyonaka, S., Hoshijima, M., Ikeda, Y., Michio, N., Ide, T., Mori, Y., Kurose, H. & Nishida, M., May 27 2011, In : Biochemical and Biophysical Research Communications. 409, 1, p. 108-113 6 p.

Research output: Contribution to journalArticle

Dilated Cardiomyopathy
Calcium-Calmodulin-Dependent Protein Kinases
Reactive Oxygen Species
NADPH Oxidase
Calmodulin
7 Citations (Scopus)
Natural Orifice Endoscopic Surgery
Cell- and Tissue-Based Therapy
Neoplasms
Visual Fields
Therapeutics
5 Citations (Scopus)

Value of laparoscopic splenectomy as salvage treatment for relapsed thrombocytopenia after partial splenic arterial embolization

Hashimoto, N., Akahoshi, T., Tomikawa, M., Kawanaka, H., Konishi, K., uehara, H., Kinjo, N., Korenaga, D., Takenaka, K. & Maehara, Y., Jan 1 2011, In : Digestive surgery. 27, 6, p. 515-520 6 p.

Research output: Contribution to journalArticle

Salvage Therapy
Splenectomy
Thrombocytopenia
Platelet Count
Hypersplenism
2010
10 Citations (Scopus)

Alendronate improves QOL of postmenopausal women with osteoporosis.

Kawate, H., Keizo, O., Adachi, M., Kono, S., Ikematsu, H., Matsuo, H., Higuchi, K., Takayama, T. & Takayanagi, R., Jan 1 2010, In : Clinical interventions in aging. 5, p. 123-131 9 p.

Research output: Contribution to journalArticle

Alendronate
Osteoporosis
Quality of Life
Bone Resorption
Visual Analog Scale
9 Citations (Scopus)

An assessment of surgery for portal hypertensive patients performed at a single community hospital

Tomikawa, M., Akahoshi, T., Sugimachi, K., Ikeda, Y., Korenaga, D., Takenaka, K., Hashizume, M. & Maehara, Y., Jul 1 2010, In : Surgery today. 40, 7, p. 620-625 6 p.

Research output: Contribution to journalArticle

Community Hospital
Splenectomy
Esophageal and Gastric Varices
Stomach
Surgical Splenorenal Shunt
39 Citations (Scopus)

An effective point-based registration tool for surgical navigation

Hong, J. & Hashizume, M., Jan 1 2010, In : Surgical Endoscopy. 24, 4, p. 944-948 5 p.

Research output: Contribution to journalArticle

Pharynx
Nose
Ear
Color
Liver
6 Citations (Scopus)

A novel SCN5A mutation associated with the linker between III and IV domains of Nav1.5 in a neonate with fatal long QT syndrome

Yamamura, K., Muneuchi, J., Uike, K., Ikeda, K., Inoue, H., Takahata, Y., Shiokawa, Y., Yoshikane, Y., Makiyama, T., Horie, M. & Hara, T., Nov 5 2010, In : International Journal of Cardiology. 145, 1, p. 61-64 4 p.

Research output: Contribution to journalArticle

Long QT Syndrome
Mutation
31 Citations (Scopus)

A surgical robot with vision field control for single port endoscopic surgery

Kobayashi, Y., Tomono, Y., Sekiguchi, Y., Watanabe, H., Toyoda, K., Konishi, K., Tomikawa, M., Ieiri, S., Tanoue, K., Hashizume, M. & Fujie, M. G., Dec 1 2010, In : International Journal of Medical Robotics and Computer Assisted Surgery. 6, 4, p. 454-464 11 p.

Research output: Contribution to journalArticle

Surgery
Manipulators
Robotics
Tissue
Cautery
128 Citations (Scopus)

Blood Pressure and hypertension are associated with 7 loci in the japanese population

Takeuchi, F., Isono, M., Katsuya, T., Yamamoto, K., Yokota, M., Sugiyama, T., Nabika, T., Fujioka, A., Keizo, O., Asano, H., Yamori, Y., Yamaguchi, S., Kobayashi, S., Takayanagi, R., Ogihara, T. & Kato, N., Jun 1 2010, In : Circulation. 121, 21, p. 2302-2309 8 p.

Research output: Contribution to journalArticle

Blood Pressure
Hypertension
Population
Genome-Wide Association Study
Genes
17 Citations (Scopus)

Circulating vitamin D and colorectal adenomas in Japanese men

Takahashi, R., Mizoue, T., Otake, T., Fukumoto, J., Tajima, O., Tabata, S., Abe, H., Keizo, O. & Kono, S., Jul 1 2010, In : Cancer Science. 101, 7, p. 1695-1700 6 p.

Research output: Contribution to journalArticle

Vitamin D
Adenoma
Odds Ratio
Colon
Anticarcinogenic Agents
17 Citations (Scopus)

Combination with low-dose gemcitabine and hTERT-promoter-dependent conditionally replicative adenovirus enhances cytotoxicity through their crosstalk mechanisms in pancreatic cancer

Onimaru, M., Ouchida, K., Nagai, E., Mizumoto, K., Egami, T., Cui, L., Sato, N., Uchino, J., Takayama, K., Hashizume, M. & Tanaka, M., Aug 1 2010, In : Cancer Letters. 294, 2, p. 178-186 9 p.

Research output: Contribution to journalArticle

gemcitabine
Pancreatic Neoplasms
Adenoviridae
Therapeutics
66 Citations (Scopus)

Common variants at the GCK, GCKR, G6PC2-ABCB11 and MTNR1B loci are associated with fasting glucose in two Asian populations

Takeuchi, F., Katsuya, T., Chakrewarthy, S., Yamamoto, K., Fujioka, A., Serizawa, M., Fujisawa, T., Nakashima, E., Keizo, O., Ikegami, H., Sugiyama, T., Nabika, T., Kasturiratne, A., Yamaguchi, S., Kono, S., Takayanagi, R., Yamori, Y., Kobayashi, S., Ogihara, T., De Silva, A. & 2 others, Wickremasinghe, R. & Kato, N., Feb 1 2010, In : Diabetologia. 53, 2, p. 299-308 10 p.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Single Nucleotide Polymorphism
Fasting
Glucose
Population
12 Citations (Scopus)

Current perspective on the role of the thrombin receptor in cerebral vasospasm after subarachnoid hemorrhage

Hirano, K. & Hirano, M., Nov 22 2010, In : Journal of Pharmacological Sciences. 114, 2, p. 127-133 7 p.

Research output: Contribution to journalArticle

Thrombin Receptors
Intracranial Vasospasm
PAR-1 Receptor
Subarachnoid Hemorrhage
Thrombin
10 Citations (Scopus)

Development of a colon endoscope robot that adjusts its locomotion through the use of reinforcement learning

Trovato, G., Shikanai, M., Ukawa, G., Kinoshita, J., Murai, N., Lee, J. W., Ishii, H., Takanishi, A., Tanoue, K., Ieiri, S., Konishi, K. & Hashizume, M., Jan 1 2010, In : International journal of computer assisted radiology and surgery. 5, 4, p. 317-325 9 p.

Research output: Contribution to journalArticle

Endoscopy
Endoscopes
Reinforcement learning
Locomotion
Colon
35 Citations (Scopus)

Development of an integrated needle insertion system with image guidance and deformation simulation

Kobayashi, Y., Onishi, A., Watanabe, H., Hoshi, T., Kawamura, K., Hashizume, M. & Fujie, M. G., Jan 1 2010, In : Computerized Medical Imaging and Graphics. 34, 1, p. 9-18 10 p.

Research output: Contribution to journalArticle

Needles
Liver
Manipulators
Swine
Ultrasonics
11 Citations (Scopus)

Discharge use of angiotensin receptor blockers provides comparable effects with angiotensin-converting enzyme inhibitors on outcomes in patients hospitalized for heart failure

Tsuchihashi-Makaya, M., Furumoto, T., Kinugawa, S., Hamaguchi, S., Goto, K., Goto, D., Yamada, S., Yokoshiki, H., Takeshita, A. & Tsutsui, H., Mar 1 2010, In : Hypertension Research. 33, 3, p. 197-202 6 p.

Research output: Contribution to journalArticle

Angiotensin Receptor Antagonists
Angiotensin-Converting Enzyme Inhibitors
Heart Failure
Left Ventricular Dysfunction
Diabetes Mellitus
2 Citations (Scopus)

Early in vivo evaluation of ventricular assistance with a miniature centrifugal blood pump (TinyPump) in rabbits

Maeda, T., Tanoue, Y., Kobayashi, M., Baba, H., Shiokawa, Y., Takatani, S. & Tominaga, R., May 1 2010, In : ASAIO Journal. 56, 3, p. 254-259 6 p.

Research output: Contribution to journalArticle

Blood
Pumps
Rabbits
Centrifugal pumps
Hemoglobin
25 Citations (Scopus)

Effectiveness of basic endoscopic surgical skill training for pediatric surgeons

Ieiri, S., Nakatsuji, T., Higashi, M., Akiyoshi, J., Uemura, M., Konishi, K., Onimaru, M., Ouchida, K., Hong, J., Tomikawa, M., Tanoue, K., Hashizume, M. & Taguchi, T., Oct 1 2010, In : Pediatric surgery international. 26, 10, p. 947-954 8 p.

Research output: Contribution to journalArticle

Pediatrics
Surgeons
Surgical Instruments
Sutures
Education

Future perspective of gastrointestinal 'intelligent' endoscopy

Konishi, K. & Hashizume, M., Jan 1 2010, In : Nippon rinsho. Japanese journal of clinical medicine. 68, 7, p. 1279-1284 6 p.

Research output: Contribution to journalArticle

Gastrointestinal Endoscopy
Endoscopy
Natural Orifice Endoscopic Surgery
Endoscopes
Technology
7 Citations (Scopus)

Gamma-secretase complexes regulate the responses of human pancreatic ductal adenocarcinoma cells to taxanes

Tasaka, T., Akiyoshi, T., Yamaguchi, K., Tanaka, M., Ohnishi, H. & Katano, M., Dec 2010, In : Anticancer Research. 30, 12, p. 4999-5010 12 p.

Research output: Contribution to journalArticle

Taxoids
Amyloid Precursor Protein Secretases
Adenocarcinoma
Apoptosis
Presenilin-1
5 Citations (Scopus)

Gemcitabine synergistically enhances the effect of adenovirus gene therapy through activation of the CMV promoter in pancreatic cancer cells

Onimaru, M., Ouchida, K., Egami, T., Mizumoto, K., Nagai, E., Cui, L., Toma, H., Matsumoto, K., Hashizume, M. & Tanaka, M., Aug 1 2010, In : Cancer Gene Therapy. 17, 8, p. 541-549 9 p.

Research output: Contribution to journalArticle

gemcitabine
Pancreatic Neoplasms
Adenoviridae
Genetic Therapy
Galactosidases
43 Citations (Scopus)

Gold nanoparticle-based colorimetric assay for cancer diagnosis

Kang, J. H., Asami, Y., Murata, M., Kitazaki, H., Sadanaga, N., Tokunaga, E., Shiotani, S., Okada, S., Maehara, Y., Niidome, T., Hashizume, M., Mori, T. & Katayama, Y., Apr 15 2010, In : Biosensors and Bioelectronics. 25, 8, p. 1869-1874 6 p.

Research output: Contribution to journalArticle

Gold
Nanoparticles
Assays
Protein Kinase C
Tissue
71 Citations (Scopus)

High mitochondrial DNA copy number has detrimental effects in mice

Ylikallio, E., Tyynismaa, H., Tsutsui, H., Ide, T. & Suomalainen, A., Apr 22 2010, In : Human Molecular Genetics. 19, 13, p. 2695-2705 11 p., ddq163.

Research output: Contribution to journalArticle

Mitochondrial DNA
Electron Transport
Mitochondrial Diseases
Bromodeoxyuridine
DNA Replication
11 Citations (Scopus)

hTERT-promoter-dependent oncolytic adenovirus enhances the transduction and therapeutic efficacy of replication-defective adenovirus vectors in pancreatic cancer cells

Onimaru, M., Ouchida, K., Mizumoto, K., Nagai, E., Cui, L., Toma, H., Takayama, K., Matsumoto, K., Hashizume, M. & Tanaka, M., Mar 1 2010, In : Cancer Science. 101, 3, p. 735-742 8 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Adenoviridae
Transgenes
Neoplasms
Therapeutics
68 Citations (Scopus)

Impact of antithrombin III concentrates on portal vein thrombosis after splenectomy in patients with liver cirrhosis and hypersplenism

Kawanaka, H., Akahoshi, T., Kinjo, N., Konishi, K., Yoshida, D., Anegawa, G., Yamaguchi, S., uehara, H., Hashimoto, N., Tsutsumi, N., Tomikawa, M. & Maehara, Y., Jan 1 2010, In : Annals of Surgery. 251, 1, p. 76-83 8 p.

Research output: Contribution to journalArticle

Hypersplenism
Antithrombin III
Splenectomy
Portal Vein
Liver Cirrhosis