Department of Advanced Medical Initiatives

Research Output 1980 2020

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79 Citations (Scopus)

Interaction of reactive astrocytes with type i collagen induces astrocytic scar formation through the integrin-N-cadherin pathway after spinal cord injury

Hara, M., Kobayakawa, K., Ohkawa, Y., Kumamaru, H., Yokota, K., Saito, T., Kijima, K., Yoshizaki, S., Harimaya, K., Nakashima, Y. & Okada, S., Jul 1 2017, In : Nature medicine. 23, 7, p. 818-828 11 p.

Research output: Contribution to journalArticle

Cadherins
Spinal Cord Injuries
Integrins
Astrocytes
Cicatrix
12 Citations (Scopus)

Intercondylar roof impingement after anatomic double-bundle anterior cruciate ligament reconstruction in patients with knee hyperextension

Matsubara, H., Okazaki, K., Tashiro, Y., Toyoda, K., Uemura, M., Hashizume, M. & Iwamoto, Y., Dec 1 2013, In : American Journal of Sports Medicine. 41, 12, p. 2819-2827 9 p.

Research output: Contribution to journalArticle

Anterior Cruciate Ligament Reconstruction
Knee
Transplants
Anterior Cruciate Ligament
Magnetic Resonance Imaging
26 Citations (Scopus)

Interferon-γ suppresses transforming growth factor-β-induced invasion of gastric carcinoma cells through cross-talk of Smad pathway in a three-dimensional culture model

Kuga, H., Morisaki, T., Nakamura, K., Onishi, H., Noshiro, H., Uchiyama, A., Tanaka, M. & Katano, M., Oct 30 2003, In : Oncogene. 22, 49, p. 7838-7847 10 p.

Research output: Contribution to journalArticle

Transforming Growth Factors
Interferons
Stomach
Carcinoma
Antisense Oligonucleotides
15 Citations (Scopus)

Intermediate-term results after the aortic valve replacement using bileaflet mechanical prosthetic valve in children

Masuda, M., Kado, H., Ando, Y., Shiose, A., Nakano, T., Fukae, K., Tanoue, Y. & Tominaga, R., Jul 1 2008, In : European Journal of Cardio-thoracic Surgery. 34, 1, p. 42-47 6 p.

Research output: Contribution to journalArticle

Aortic Valve
Prostheses and Implants
Thrombosis
Aortic Diseases
Doppler Echocardiography
29 Citations (Scopus)

Interventional navigation for abdominal therapy based on simultaneous use of MRI and ultrasound

Hong, J., Nakashima, H., Konishi, K., Ieiri, S., Tanoue, K., Nakamuta, M. & Hashizume, M., Dec 1 2006, In : Medical and Biological Engineering and Computing. 44, 12, p. 1127-1134 8 p.

Research output: Contribution to journalArticle

Magnetic resonance imaging
Needles
Navigation
Ultrasonics
Tumors
23 Citations (Scopus)

Intimal response of saphenous vein to intraluminal trauma by simulated angioscopic insertion

Hashizume, M., Yang, Y., Galt, S., Murthy, S. N. S. & Matsumoto, T., Jan 1 1987, In : Journal of Vascular Surgery. 5, 6, p. 862-868 7 p.

Research output: Contribution to journalArticle

Tunica Intima
Saphenous Vein
Veins
Wounds and Injuries
Epoprostenol
10 Citations (Scopus)

Intracardiac echocardiography-guided cardiac tumor biopsy

Higo, T., Takemoto, M., Ogawa, K., Inoue, S., Eshima, K. I., Tada, H. & Sunagawa, K., Feb 10 2009, In : Circulation Journal. 73, 2, p. 381-383 3 p.

Research output: Contribution to journalArticle

Heart Neoplasms
Echocardiography
Biopsy
Heart Atria
Heart Ventricles
17 Citations (Scopus)

Intracellular alkalinization induces Ca2+ influx via non-voltage-operated Ca2+ channels in rat aortic smooth muscle cells

Eto, W., Hirano, K., Hirano, M., Nishimura, J. & Kanaide, H., Dec 2003, In : Cell Calcium. 34, 6, p. 477-484 8 p.

Research output: Contribution to journalArticle

1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole
Diltiazem
Smooth Muscle Myocytes
Fluorometry
Fura-2
121 Citations (Scopus)

Intramural delivery of a specific tyrosine kinase inhibitor with biodegradable stent suppresses the restenotic changes of the coronary artery in pigs in vivo

Yamawaki, T., Shimokawa, H., Kozai, T., Miyata, K., Higo, T., Tanaka, E., Egashira, K., Shiraishi, T., Tamai, H., Igaki, K. & Takeshita, A., Sep 1 1998, In : Journal of the American College of Cardiology. 32, 3, p. 780-786 7 p.

Research output: Contribution to journalArticle

Protein-Tyrosine Kinases
Stents
Coronary Vessels
Swine
Coronary Stenosis
73 Citations (Scopus)

Intramuscular metabolism during low-intensity resistance exercise with blood flow restriction

Suga, T., Okita, K., Morita, N., Yokota, T., Hirabayashi, K., Horiuchi, M., Takada, S., Takahashi, T., Omokawa, M., Kinugawa, S. & Tsutsui, H., Apr 1 2009, In : Journal of Applied Physiology. 106, 4, p. 1119-1124 6 p.

Research output: Contribution to journalArticle

Exercise
Resistance Training
Phosphocreatine
Phosphates
Physiological Stress
8 Citations (Scopus)

Intraoperative hemostasis and wound healing in intestinalanastomoses using the ILA stapling device

Berman, S., Hashizume, M., Yang, Y., DuPree, J. & Matsumoto, T., Mar 1988, In : The American Journal of Surgery. 155, 3, p. 520-525 6 p.

Research output: Contribution to journalArticle

Hemostasis
Wound Healing
Microvessels
Silicone Elastomers
Equipment and Supplies
52 Citations (Scopus)

Intraoperative magnetic tracker calibration using a magneto-optic hybrid tracker for 3-D ultrasound-based navigation in laparoscopic surgery

Nakamoto, M., Nakada, K., Sato, Y., Konishi, K., Hashizume, M. & Tamura, S., Dec 1 2008, In : IEEE Transactions on Medical Imaging. 27, 2, p. 255-270 16 p., 4374097.

Research output: Contribution to journalArticle

Magnetooptical effects
Laparoscopy
Surgery
Calibration
Navigation
12 Citations (Scopus)

Intraoperative visualization of cerebral oxygenation using hyperspectral image data: a two-dimensional mapping method

Mori, M., Chiba, T., Nakamizo, A., Kumashiro, R., Murata, M., Akahoshi, T., Tomikawa, M., Kikkawa, Y., Yoshimoto, K., Mizoguchi, M., Sasaki, T. & Hashizume, M., Jan 1 2014, In : International Journal of Computer Assisted Radiology and Surgery. 9, 6, p. 1059-1072 14 p.

Research output: Contribution to journalArticle

Oxygenation
Visualization
Hemodynamics
Imaging techniques
Temporal Arteries
101 Citations (Scopus)

Intratumoral CD8+ T/FOXP3+ cell ratio is a predictive marker for survival in patients with colorectal cancer

Suzuki, H., Chikazawa, N., Tasaka, T., Wada, J., Yamasaki, A., Kitaura, Y., Sozaki, M., Tanaka, M., Onishi, H., Morisaki, T. & Katano, M., May 1 2010, In : Cancer Immunology, Immunotherapy. 59, 5, p. 653-661 9 p.

Research output: Contribution to journalArticle

Colorectal Neoplasms
Survival
Disease-Free Survival
T-Lymphocytes
Neoplasms
20 Citations (Scopus)

Intratumoral FOXP3+VEGFR2+ regulatory T cells are predictive markers for recurrence and survival in patients with colorectal cancer

Suzuki, H., Onishi, H., Morisaki, T., Tanaka, M. & Katano, M., Jan 1 2013, In : Clinical Immunology. 146, 1, p. 26-33 8 p.

Research output: Contribution to journalArticle

Regulatory T-Lymphocytes
Colorectal Neoplasms
Recurrence
Survival
Disease-Free Survival
11 Citations (Scopus)

Intravenous electrical vagal nerve stimulation prior to coronary reperfusion in a canine ischemia-reperfusion model markedly reduces infarct size and prevents subsequent heart failure

Arimura, T., Saku, K., Kakino, T., Nishikawa, T., Tohyama, T., Sakamoto, T., Sakamoto, K., Kishi, T., Ide, T. & Sunagawa, K., Jan 15 2017, In : International Journal of Cardiology. 227, p. 704-710 7 p.

Research output: Contribution to journalArticle

Vagus Nerve Stimulation
Myocardial Reperfusion
Reperfusion
Canidae
Ischemia
61 Citations (Scopus)

Inverse associations of serum bilirubin with high sensitivity C-reactive protein, glycated hemoglobin, and prevalence of type 2 diabetes in middle-aged and elderly Japanese men and women

Ohnaka, K., Kono, S., Inoguchi, T., Yin, G., Morita, M., Adachi, M., Kawate, H. & Takayanagi, R., Apr 1 2010, In : Diabetes Research and Clinical Practice. 88, 1, p. 103-110 8 p.

Research output: Contribution to journalArticle

Glycosylated Hemoglobin A
Bilirubin
C-Reactive Protein
Type 2 Diabetes Mellitus
Serum
4 Citations (Scopus)

Investigation of the cause of readmission to the intensive care unit for patients with lung edema or atelectasis

Matsuoka, Y., Zaitsu, A. & Hashizume, M., Jun 1 2008, In : Yonsei Medical Journal. 49, 3, p. 422-428 7 p.

Research output: Contribution to journalArticle

Pulmonary Atelectasis
Intensive Care Units
Edema
Lung
Body Weight
5 Citations (Scopus)

In vivo redox metabolic imaging of mitochondria assesses disease progression in non-alcoholic steatohepatitis

Nakata, R., Hyodo, F., Murata, M., Eto, H., Nakaji, T., Kawano, T., Narahara, S., Yasukawa, K., Akahoshi, T., Tomikawa, M. & Hashizume, M., Dec 1 2017, In : Scientific reports. 7, 1, 17170.

Research output: Contribution to journalArticle

Fatty Liver
Oxidation-Reduction
Disease Progression
Mitochondria
Biopsy

Involvement of different receptor subtypes in prostaglandin E2-induced contraction and relaxation in the lower esophageal sphincter and esophageal body

Bai, X., Ihara, E., Otsuka, Y., Tsuruta, S., Hirano, K., Tanaka, Y., Ogino, H., Hirano, M., Chinen, T., Akiho, H., Nakamura, K., Oda, Y. & Ogawa, Y., Aug 15 2019, In : European Journal of Pharmacology. 857, 172405.

Research output: Contribution to journalArticle

Lower Esophageal Sphincter
Dinoprostone
Smooth Muscle
Gastroesophageal Reflux
Muscle Contraction
12 Citations (Scopus)

Involvement of Gi/o in the PAR-4-induced NO production in endothelial cells

Momota, F., Hirano, K., Hirano, M., Nishimura, J. & Kanaide, H., Apr 7 2006, In : Biochemical and Biophysical Research Communications. 342, 2, p. 365-371 7 p.

Research output: Contribution to journalArticle

Proteinase-Activated Receptors
Ionomycin
Endothelial cells
Endothelial Cells
Thrombin
8 Citations (Scopus)

Involvement of Na +-Ca 2+ exchanger in cAMP-mediated relaxation in mice aorta: Evaluation using transgenic mice

Karashima, E., Nishimura, J., Iwamoto, T., Hirano, K., Hirano, M., Kita, S., Harada, M. & Kanaide, H., Feb 1 2007, In : British Journal of Pharmacology. 150, 4, p. 434-444 11 p.

Research output: Contribution to journalArticle

Sodium-Calcium Exchanger
Colforsin
Transgenic Mice
Aorta
Thoracic Aorta
16 Citations (Scopus)

Involvement of reactive oxygen species in thrombin-induced pulmonary vasoconstriction

Maki, J., Hirano, M., Hoka, S., Kanaide, H. & Hirano, K., Dec 1 2010, In : American Journal of Respiratory and Critical Care Medicine. 182, 11, p. 1435-1444 10 p.

Research output: Contribution to journalArticle

Vasoconstriction
Thrombin
Reactive Oxygen Species
Phosphorylation
Lung
18 Citations (Scopus)

Involvement of STIM1 in the proteinase-activated receptor 1-mediated Ca2+ influx in vascular endothelial cells

Hirano, K., Hirano, M. & Hanada, A., Oct 1 2009, In : Journal of Cellular Biochemistry. 108, 2, p. 499-507 9 p.

Research output: Contribution to journalArticle

PAR-1 Receptor
Endothelial cells
Endothelial Cells
Thrombin
Molecules
20 Citations (Scopus)

Isolated ACTH deficiency probably induced by autoimmune-related mechanism evoked with nivolumab

Kitajima, K., Ashida, K., Wada, N., Suetsugu, R., Takeichi, Y., Sakamoto, S., Uchi, H., Matsushima, T., Shiratsuchi, M., Ohnaka, K., Furue, M. & Nomura, M., May 1 2017, In : Japanese journal of clinical oncology. 47, 5, p. 463-466 4 p., hyx018.

Research output: Contribution to journalArticle

Adrenocorticotropic Hormone
Hydrocortisone
Melanoma
Magnetic Resonance Imaging
Anterior Pituitary Hormones
10 Citations (Scopus)

Isolated pulmonary valve replacement: Analysis of 27 years of experience

Tokunaga, S., Masuda, M., Shiose, A., Tomita, Y., Morita, S. & Tominaga, R., Sep 1 2008, In : Journal of Artificial Organs. 11, 3, p. 130-133 4 p.

Research output: Contribution to journalArticle

Bioprosthesis
Pulmonary Valve
Allografts
Thrombosis
Survival Rate

Japanese periodical nationwide epidemiologic survey of aberrant portal hemodynamics

Ohfuji, S., Furuichi, Y., Akahoshi, T., Kage, M., Obara, K., Hashizume, M., Matsuura, T., Fukushima, W. & Nakamura, Y., Aug 1 2019, In : Hepatology Research. 49, 8, p. 890-901 12 p.

Research output: Contribution to journalArticle

Open Access
Hemodynamics
Japan
Pediatrics
Epidemiologic Methods
Surveys and Questionnaires
3 Citations (Scopus)

Japan Medical Association's actions in the Great Eastern Japan Earthquake

Ishii, M., Nagata, T. & Aoki, K., Dec 1 2011, In : World Medical and Health Policy. 3, 4, 2.

Research output: Contribution to journalArticle

Earthquakes
Japan
Disasters
Delivery of Health Care
Disaster Planning

Jarvik 2000 axial flow ventricular assist device in right single ventricle after Fontan operation

Tanoue, Y., Fujino, T., Tatewaki, H. & Shiose, A., Dec 1 2019, In : Journal of Artificial Organs. 22, 4, p. 338-340 3 p.

Research output: Contribution to journalArticle

Fontan Procedure
Heart-Assist Devices
Axial flow
Heart Ventricles
Dextrocardia

JCS 2017/JHFS 2017 guideline on diagnosis and treatment of acute and chronic heart failure ― digest version ―

behalf of the Japanese Circulation Society and the Japanese Heart Failure Society Joint Working Group, Jan 1 2019, In : Circulation Journal. 83, 10, p. 2084-2184 101 p.

Research output: Contribution to journalArticle

Open Access
Heart Failure
Guidelines
6 Citations (Scopus)

JCS 2018 guideline on diagnosis and treatment of acute coronary syndrome

on behalf of the Japanese Circulation Society Joint Working Group, Jan 1 2019, In : Circulation Journal. 83, 5, p. 1085-1196 112 p.

Research output: Contribution to journalArticle

Open Access
Acute Coronary Syndrome
Guidelines
10 Citations (Scopus)

Jejunal variceal bleeding after esophageal transection in a patient with idiopathic portal hypertension

Migou, S. I., Hashizume, M., Tsugawa, K., Kishihara, F., Kawanaka, H., Ohta, M., Tanoue, K., Kuroiwa, T., Kawamoto, K. & Sugimachi, K., Apr 27 1998, In : Hepato-gastroenterology. 45, 20, p. 503-507 5 p.

Research output: Contribution to journalArticle

Hemorrhage
Varicose Veins
Small Intestine
Lower Gastrointestinal Tract
Esophageal and Gastric Varices
Biomedical Engineering
Minimally Invasive Surgical Procedures
Robotics
Medical Education
Japan
19 Citations (Scopus)

Laparascopic splenectomy for an inflammatory pseudotumor of the spleen: Operative technique and case report

Tsugawa, K., Hashizume, M., Migou, S., Kawanaka, H., Sugimachi, K., Irie, H., Maeda, T. & Akaboshi, K., Jan 1 1998, In : Hepato-gastroenterology. 45, 23, p. 1887-1891 5 p.

Research output: Contribution to journalArticle

Plasma Cell Granuloma
Splenectomy
Spleen
Hemangioma
Ultrasonography
28 Citations (Scopus)

Laparoscope-assisted distal gastrectomy for early gastric cancer in a 76-year-old man with situs inversus totalis.

Yamaguchi, S., Orita, H., Yamaoka, T., Mii, S., Sakata, H. & Hashizume, M., Feb 2003, In : Surgical endoscopy. 17, 2, p. 352-353 2 p.

Research output: Contribution to journalArticle

Laparoscopes
Situs Inversus
Gastrectomy
Stomach Neoplasms
Laparoscopy
20 Citations (Scopus)

Laparoscopic cholecystectomy using a newly developed laparoscope manipulator for 10 patients with cholelithiasis

Tanoue, K., Yasunaga, T., Kobayashi, E., Miyamoto, S., Sakuma, I., Dohi, T., Konishi, K., Yamaguchi, S., Kinjo, N., Takenaka, K., Maehara, Y. & Hashizume, M., May 1 2006, In : Surgical Endoscopy and Other Interventional Techniques. 20, 5, p. 753-756 4 p.

Research output: Contribution to journalArticle

Laparoscopes
Cholelithiasis
Laparoscopic Cholecystectomy
Operative Time
Robotics
8 Citations (Scopus)

Laparoscopic disconnection of a huge paraumbilical vein shunt for portosystemic encephalopathy

Yamaguchi, S., Kawanaka, H., Konishi, K., Anegawa, G., Yoshida, D., Kinjo, N., Tomikawa, M., Hashizume, M. & Maehara, Y., Jun 1 2007, In : Surgical Laparoscopy, Endoscopy and Percutaneous Techniques. 17, 3, p. 212-214 3 p.

Research output: Contribution to journalArticle

Hepatic Encephalopathy
Chronic Brain Damage
Veins
Surgical Portasystemic Shunt
Round Ligaments
14 Citations (Scopus)

Laparoscopic drainage of pyogenic liver abscess

Yanaga, K., Kitano, S., Hashizume, M., Ohta, M., Matsumata, T. & Sugimachi, K., Jul 1994, In : British Journal of Surgery. 81, 7, p. 1022 1 p.

Research output: Contribution to journalArticle

48 Citations (Scopus)

Laparoscopic gastric devascularization and splenectomy for sclerotherapyo-resistant esophagogastric varices with hypersplenism

Hashizume, M., Tanoue, K., Morita, M., Ohta, M., Tomikawa, M. & Sugimachi, K., Oct 3 1998, In : Journal of the American College of Surgeons. 187, 3, p. 263-270 8 p.

Research output: Contribution to journalArticle

Hypersplenism
Varicose Veins
Splenectomy
Stomach
Sclerotherapy
40 Citations (Scopus)

Laparoscopic hepatectomy: New approach for hepatocellular carcinoma

Hashizume, M., Shimada, M. & Sugimachi, K., Jan 1 2000, In : Journal of Hepato-Biliary-Pancreatic Surgery. 7, 3, p. 270-275 6 p.

Research output: Contribution to journalArticle

Hepatectomy
Hepatocellular Carcinoma
Liver
Laparoscopy
Technology
150 Citations (Scopus)

Laparoscopic hepatectomy for hepatocellular carcinoma

Shimada, M., Hashizume, M., Maehara, S., Tsujita, E., Rikimaru, T., Yamashita, Y., Tanaka, S., Adachi, E. & Sugimachi, K., Jun 13 2001, In : Surgical endoscopy. 15, 6, p. 541-544 4 p.

Research output: Contribution to journalArticle

Hepatectomy
Hepatocellular Carcinoma
Survival Rate
Blood Transfusion
Disease-Free Survival
108 Citations (Scopus)

Laparoscopic hepatic resection for hepatocellular carcinoma

Hashizume, M., Takenaka, K., Yanaga, K., Ohta, M., Kajiyama, K., Shirabe, K., Itasaka, H., Nishizaki, T. & Sugimachi, K., Dec 1 1995, In : Surgical endoscopy. 9, 12, p. 1289-1291 3 p.

Research output: Contribution to journalArticle

Hepatocellular Carcinoma
Liver
Air Embolism
Hepatic Veins
Microwaves
67 Citations (Scopus)

Laparoscopic ligation of splenic artery aneurysm

Hashizume, M., Ohta, M., Ueno, K., Okadome, K. & Sugimachi, K., Mar 1993, In : Surgery. 113, 3, p. 352-354 3 p.

Research output: Contribution to journalArticle

Splenic Artery
Aneurysm
Ligation
Spleen
Cholelithiasis
5 Citations (Scopus)

Laparoscopic oversewing of a bleeding Mallory-Weiss tear under endoscopic guidance

Kitano, S., Ueno, K., Hashizume, M., Ohta, M., Tomikawa, M. & Sugimachi, K., Sep 1 1993, In : Surgical endoscopy. 7, 5, p. 445-446 2 p.

Research output: Contribution to journalArticle

Mallory-Weiss Syndrome
Hemorrhage
Esophagogastric Junction
Lacerations
Tears
14 Citations (Scopus)

Laparoscopic rectopexy for recurrent rectal prolapse: A safe and simple procedure without a mesh prosthesis

Tsugawa, K., Sue, K., Koyanagi, N., Hashizume, M., Wada, H., Tomikawa, M. & Sugimachi, K., Nov 1 2002, In : Hepato-gastroenterology. 49, 48, p. 1549-1551 3 p.

Research output: Contribution to journalArticle

Rectal Prolapse
Prostheses and Implants
Prolapse
Intraoperative Complications
Recurrence
11 Citations (Scopus)

Laparoscopic repair of a paraesophageal hiatal hernia with gastric volvulus

Kuwano, H., Hashizume, M., Ohta, M., Sumiyoshi, K., Sugimachi, K. & Haraguchi, Y., Feb 19 1998, In : Hepato-gastroenterology. 45, 19, p. 303-306 4 p.

Research output: Contribution to journalArticle

Stomach Volvulus
Hiatal Hernia
Laparoscopy
Pressure
Recurrence
4 Citations (Scopus)

Laparoscopic repair of a perforated duodenal ulcer in two patients

Kabashima, A., Maehara, Y., Hashizume, M., Tomoda, M., Kakeji, Y., Ohno, S. & Sugimachi, K., Jul 2 1998, In : Surgery today. 28, 6, p. 633-635 3 p.

Research output: Contribution to journalArticle

Duodenal Ulcer
Hepatocellular Carcinoma
Lung Neoplasms
Diabetes Mellitus
Asthma
8 Citations (Scopus)

Laparoscopic repair of paraumbilical ventral hernia with increasing size in an obese patient

Hashizume, M., Migo, S., Tsugawa, Y., Tanoue, K., Ohta, M., Kumashiro, R. & Sugimachi, K., Sep 1996, In : Surgical endoscopy. 10, 9, p. 933-935 3 p.

Research output: Contribution to journalArticle

Ventral Hernia
Polytetrafluoroethylene
Abdominal Wall
Morbidity
Therapeutics
3 Citations (Scopus)

Laparoscopic resection of an isolated retroperitoneal enteric duplication in an infant

Souzaki, R., Ieiri, S., Kinoshita, Y., Nishie, A., Koga, Y., Kuda, M., Oda, Y., Hara, T., Hashizume, M. & Taguchi, T., Jul 1 2013, In : Journal of Pediatric Surgery Case Reports. 1, 7, p. 167-170 4 p.

Research output: Contribution to journalArticle

Adrenal Glands
Cysts
Communication
Observation
Parturition
14 Citations (Scopus)

Laparoscopic splenectomy: The latest modern technique

Hashizume, M., Tanoue, K., Akahoshi, T., Morita, M., Ohta, M., Tomikawa, M. & Sugimachi, K., May 25 1999, In : Hepato-gastroenterology. 46, 26, p. 820-824 5 p.

Research output: Contribution to journalArticle

Splenectomy
Portal Hypertension
Spleen
Splenic Vein
Conversion to Open Surgery