Department of Advanced Medical Initiatives

Research Output 1980 2019

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Article
2010
25 Citations (Scopus)
Myofibrils
Subarachnoid Hemorrhage
Blood Vessels
Thrombin
Intracranial Vasospasm
87 Citations (Scopus)

Inhibition of Wnt signaling pathway decreases chemotherapy-resistant side-population colon cancer cells

Chikazawa, N., Tanaka, H., Tasaka, T., Nakamura, M., Tanaka, M., Ohnishi, H. & Katano, M., Jun 2010, In : Anticancer Research. 30, 6, p. 2041-2048 8 p.

Research output: Contribution to journalArticle

Side-Population Cells
Wnt Signaling Pathway
irinotecan
Colonic Neoplasms
Drug Therapy
99 Citations (Scopus)

Intratumoral CD8+ T/FOXP3+ cell ratio is a predictive marker for survival in patients with colorectal cancer

Suzuki, H., Chikazawa, N., Tasaka, T., Wada, J., Yamasaki, A., Kitaura, Y., Sozaki, M., Tanaka, M., Ohnishi, H., Morisaki, T. & Katano, M., May 1 2010, In : Cancer Immunology, Immunotherapy. 59, 5, p. 653-661 9 p.

Research output: Contribution to journalArticle

Colorectal Neoplasms
Survival
Disease-Free Survival
T-Lymphocytes
Neoplasms
59 Citations (Scopus)

Inverse associations of serum bilirubin with high sensitivity C-reactive protein, glycated hemoglobin, and prevalence of type 2 diabetes in middle-aged and elderly Japanese men and women

Keizo, O., Kono, S., Inoguchi, T., Yin, G., Morita, M., Adachi, M., Kawate, H. & Takayanagi, R., Apr 1 2010, In : Diabetes Research and Clinical Practice. 88, 1, p. 103-110 8 p.

Research output: Contribution to journalArticle

Glycosylated Hemoglobin A
Bilirubin
C-Reactive Protein
Type 2 Diabetes Mellitus
Serum
16 Citations (Scopus)

Involvement of reactive oxygen species in thrombin-induced pulmonary vasoconstriction

Maki, J., Hirano, M., Hoka, S., Kanaide, H. & Hirano, K., Dec 1 2010, In : American Journal of Respiratory and Critical Care Medicine. 182, 11, p. 1435-1444 10 p.

Research output: Contribution to journalArticle

Vasoconstriction
Thrombin
Reactive Oxygen Species
Phosphorylation
Lung
37 Citations (Scopus)

Laparoscopic splenectomy may be a superior supportive intervention for cirrhotic patients with hypersplenism

Tomikawa, M., Akahoshi, T., Sugimachi, K., Ikeda, Y., Yoshida, K., Tanabe, Y., Kawanaka, H., Takenaka, K., Hashizume, M. & Maehara, Y., Jan 1 2010, In : Journal of Gastroenterology and Hepatology (Australia). 25, 2, p. 397-402 6 p.

Research output: Contribution to journalArticle

Hypersplenism
Splenectomy
Interferons
Therapeutics
Hepatocellular Carcinoma
40 Citations (Scopus)

Long-term outcomes and the quality of life of Hirschsprung disease in adolescents who have reached 18 years or older-a 47-year single-institute experience

Ieiri, S., Nakatsuji, T., Akiyoshi, J., Higashi, M., Hashizume, M., Suita, S. & Taguchi, T., Dec 1 2010, In : Journal of Pediatric Surgery. 45, 12, p. 2398-2402 5 p.

Research output: Contribution to journalArticle

Hirschsprung Disease
Quality of Life
Reference Values
Surveys and Questionnaires
Pediatrics
4 Citations (Scopus)

Molecular imaging contrast media for visualization of liver function

Yoshinori, M., Murata, M., Yuri, H., Sayoko, N., Nao, S. & Hashizume, M., Jun 1 2010, In : Magnetic Resonance Imaging. 28, 5, p. 708-715 8 p.

Research output: Contribution to journalArticle

Contrast media
Molecular imaging
Molecular Imaging
Liver
Contrast Media

Moyamoya disease in which pentazocine treatment caused cerebral infarction.

Matsuoka, Y. & Hashizume, M., Jan 1 2010, In : BMJ case reports. 2010

Research output: Contribution to journalArticle

Moyamoya Disease
Pentazocine
Cerebral Infarction
Middle Cerebral Artery
Consciousness
153 Citations (Scopus)

Natural killer T cells are involved in adipose tissues inflammation and glucose intolerance in diet-induced obese mice

Ohmura, K., Ishimori, N., Ohmura, Y., Tokuhara, S., Nozawa, A., Horii, S., Andoh, Y., Fujii, S., Iwabuchi, K., Onoé, K. & Tsutsui, H., Jan 1 2010, In : Arteriosclerosis, thrombosis, and vascular biology. 30, 2, p. 193-199 7 p.

Research output: Contribution to journalArticle

Obese Mice
Natural Killer T-Cells
Glucose Intolerance
Adipose Tissue
Diet

NKG2D-mediated tumor recognition and cancer immunotherapy

Morisaki, T., Tanaka, H., Kiyota, A., Koya, N., Ohnishi, H., Yamasaki, A., Suzuki, H., Nakamura, M. & Katano, M., Jan 2010, In : Biotherapy. 24, 1, p. 40-45 6 p.

Research output: Contribution to journalArticle

Immunotherapy
Lymphocytes
Neoplasms
T-Lymphocytes
Adoptive Immunotherapy
32 Citations (Scopus)

Nuclear factor kappaB-activated monocytes contribute to pancreatic cancer progression through the production of Shh

Yamasaki, A., Kameda, C., Xu, R., Tanaka, H., Tasaka, T., Chikazawa, N., Suzuki, H., Morisaki, T., Kubo, M., Ohnishi, H., Tanaka, M. & Katano, M., May 1 2010, In : Cancer Immunology, Immunotherapy. 59, 5, p. 675-686 12 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Monocytes
Stromal Cells
Neoplasms
Cell Proliferation
1 Citation (Scopus)
Conjugated (USP) Estrogens
Estrogen Replacement Therapy
Thrombosis
Hemoptysis
Fluoroscopy
38 Citations (Scopus)

Oestrogen receptor-α contributes to the regulation of the hedgehog signalling pathway in ERα-positive gastric cancer

Kameda, C., Nakamura, M., Tanaka, H., Yamasaki, A., Kubo, M., Tanaka, M., Ohnishi, H. & Katano, M., Feb 1 2010, In : British journal of cancer. 102, 4, p. 738-747 10 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Stomach Neoplasms
Cell Proliferation
Small Interfering RNA
Estrogens
32 Citations (Scopus)

Overexpression of mitochondrial transcription factor A (TFAM) ameliorates delayed neuronal death due to transient forebrain ischemia in mice

Hokari, M., Kuroda, S., Kinugawa, S., Ide, T., Tsutsui, H. & Iwasaki, Y., Aug 1 2010, In : Neuropathology. 30, 4, p. 401-407 7 p.

Research output: Contribution to journalArticle

Prosencephalon
Transgenic Mice
Ischemia
Common Carotid Artery
Hippocampal CA1 Region
2 Citations (Scopus)

Para-hisian pacing for a pediatric patient with a congenitally corrected transposition of the great arteries (SLL)

Takemoto, M., Nakashima, A., Muneuchi, J., Yamamura, K., Shiokawa, Y., Sunagawa, K. & Tominaga, R., Jan 1 2010, In : PACE - Pacing and Clinical Electrophysiology. 33, 1

Research output: Contribution to journalArticle

Ventricular Dysfunction
Bundle of His
Pediatrics
Atrioventricular Block
Mitral Valve
62 Citations (Scopus)

Phosphorylation of TRPC6 channels at Thr69 is required for anti-hypertrophic effects of phosphodiesterase 5 inhibition

Nishida, M., Watanabe, K., Sato, Y., Michio, N., Kitajima, N., Ide, T., Inoue, R. & Kurose, H., Apr 23 2010, In : Journal of Biological Chemistry. 285, 17, p. 13244-13253 10 p.

Research output: Contribution to journalArticle

Type 5 Cyclic Nucleotide Phosphodiesterases
Phosphorylation
Cyclic GMP-Dependent Protein Kinases
Cardiomegaly
Chemical activation
10 Citations (Scopus)

Posterior displacement of the tibia increases in deep flexion of the knee

Fukagawa, S., Matsuda, S., Tashiro, Y., Hashizume, M. & Iwamoto, Y., Apr 1 2010, In : Clinical orthopaedics and related research. 468, 4, p. 1107-1114 8 p.

Research output: Contribution to journalArticle

Tibia
Knee
Interventional Magnetic Resonance Imaging
Bone and Bones
Knee Replacement Arthroplasties
8 Citations (Scopus)

Raloxifene induces nucleolar translocation of the estrogen receptor

Gushima, M., Kawate, H., Keizo, O., Nomura, M. & Takayanagi, R., May 5 2010, In : Molecular and Cellular Endocrinology. 319, 1-2, p. 14-22 9 p.

Research output: Contribution to journalArticle

Estrogen Receptor alpha
Estrogen Receptors
Tissue
Selective Estrogen Receptor Modulators
Organ Specificity
15 Citations (Scopus)

Real-Time 3-Dimensional Virtual Reality Navigation System with Open MRI for Breast-Conserving Surgery

Tomikawa, M., Hong, J., Shiotani, S., Tokunaga, E., Konishi, K., Ieiri, S., Tanoue, K., Akahoshi, T., Maehara, Y. & Hashizume, M., Jun 1 2010, In : Journal of the American College of Surgeons. 210, 6, p. 927-933 7 p.

Research output: Contribution to journalArticle

Segmental Mastectomy
Coloring Agents
Breast Neoplasms
Carcinoma, Intraductal, Noninfiltrating
Punctures
3 Citations (Scopus)

Relation of cigarette smoking, alcohol use, and coffee consumption to glycated hemoglobin in Japanese men and women

Maki, T., Ikeda, M., Morita, M., Keizo, O., Kawate, H., Adachi, M., Takayanagi, R. & Kono, S., Apr 1 2010, In : Diabetes and Metabolic Syndrome: Clinical Research and Reviews. 4, 2, p. 69-73 5 p.

Research output: Contribution to journalArticle

Coffee
Glycosylated Hemoglobin A
Smoking
Alcohols
Odds Ratio
20 Citations (Scopus)

Relation of coffee consumption and serum liver enzymes in Japanese men and women with reference to effect modification of alcohol use and body mass index

Ikeda, M., Maki, T., Yin, G., Kawate, H., Adachi, M., Keizo, O., Takayanagi, R. & Kono, S., Apr 30 2010, In : Scandinavian Journal of Clinical and Laboratory Investigation. 70, 3, p. 171-179 9 p.

Research output: Contribution to journalArticle

Coffee
Liver
Body Mass Index
Alcohols
Alanine Transaminase

Requisites for the remote-controlled wide-view CCD camera unit for natural orifice transluminal endoscopic surgery placed in the intraperitoneal cavity.

Ohdaira, T., Yasuda, Y. & Hashizume, M., Jan 1 2010, In : Surgical technology international. 19, p. 38-46 9 p.

Research output: Contribution to journalArticle

Natural Orifice Endoscopic Surgery
Lenses
Endoscopes
Water Supply
Anal Canal
15 Citations (Scopus)

Ribonucleotide reductase is not limiting for mitochondrial DNA copy number in mice

Ylikallio, E., Page, J. L., Xu, X., Lampinen, M., Bepler, G., Ide, T., Tyynismaa, H., Weiss, R. S. & Suomalainen, A., Dec 1 2010, In : Nucleic acids research. 38, 22, p. 8208-8218 11 p.

Research output: Contribution to journalArticle

Ribonucleotide Reductases
Mitochondrial DNA
Deoxyribonucleosides
Maintenance
Mammals
69 Citations (Scopus)

Risk factors for portal venous thrombosis after splenectomy in patients with cirrhosis and portal hypertension

Kinjo, N., Kawanaka, H., Akahoshi, T., Tomikawa, M., Yamashita, N., Konishi, K., Tanoue, K., Shirabe, K., Hashizume, M. & Maehara, Y., Jun 1 2010, In : British Journal of Surgery. 97, 6, p. 910-916 7 p.

Research output: Contribution to journalArticle

Portal Hypertension
Splenectomy
Venous Thrombosis
Fibrosis
Splenic Vein
27 Citations (Scopus)

Skills assessment using a virtual reality simulator, LapSim™, after training to develop fundamental skills for endoscopic surgery

Tanoue, K., Uemura, M., Kenmotsu, H., Ieiri, S., Konishi, K., Ouchida, K., Onimaru, M., Nagao, Y., Kumashiro, R., Tomikawa, M. & Hashizume, M., Feb 1 2010, In : Minimally Invasive Therapy and Allied Technologies. 19, 1, p. 24-29 6 p.

Research output: Contribution to journalArticle

Feasibility Studies
Safety
Education
Surgeons

Successful adaptive servo-ventilation for patients with acute cardiogenic pulmonary edema due to severe aortic stenosis

Sakakibara, M., Yamada, S., Matsushima, S., Saito, A., Masaki, Y., Honma, T., Kubota, S., Matsui, Y. & Tsutsui, H., Oct 1 2010, In : Journal of Cardiology Cases. 2, 2

Research output: Contribution to journalArticle

Aortic Valve Stenosis
Pulmonary Edema
Ventilation
Hemodynamics
Noninvasive Ventilation

Successful salvage after necrotizing fasciitis in a lower extremity with hip and knee replacement

Tashiro, Y., Shuto, T., Yoshida, T., Sakamoto, A., Yamamoto, S., Hashizume, M. & Iwamoto, Y., Mar 1 2010, In : Current Orthopaedic Practice. 21, 2, p. 223-225 3 p.

Research output: Contribution to journalArticle

Necrotizing Fasciitis
Hip
Lower Extremity
Knee
33 Citations (Scopus)

Surface-bound TGF-β1 on effusion-derived exosomes participates in maintenance of number and suppressive function of regulatory T-cells in malignant effusions

Wada, J., Ohnishi, H., Suzuki, H., Yamasaki, A., Nagai, S., Morisaki, T. & Katano, M., Sep 1 2010, In : Anticancer research. 30, 9, p. 3747-3757 11 p.

Research output: Contribution to journalArticle

Exosomes
Regulatory T-Lymphocytes
Maintenance
Immunotherapy
Blood Cells
73 Citations (Scopus)

Tenascin-C may aggravate left ventricular remodeling and function after myocardial infarction in mice

Nishioka, T., Onishi, K., Shimojo, N., Nagano, Y., Matsusaka, H., Ikeuchi, M., Ide, T., Tsutsui, H., Hiroe, M., Yoshida, T. & Imanaka-Yoshida, K., Mar 1 2010, In : American Journal of Physiology - Heart and Circulatory Physiology. 298, 3

Research output: Contribution to journalArticle

Tenascin
Ventricular Remodeling
Left Ventricular Function
Myocardial Infarction
Myocardium
22 Citations (Scopus)

The efficacy of balloon-occluded retrograde transvenous obliteration on small intestinal variceal bleeding

Hashimoto, N., Akahoshi, T., Yoshida, D., Kinjo, N., Konishi, K., uehara, H., Nagao, Y., Kawanaka, H., Tomikawa, M. & Maehara, Y., Jul 1 2010, In : Surgery. 148, 1, p. 145-150 6 p.

Research output: Contribution to journalArticle

Hemorrhage
Esophageal and Gastric Varices
Varicose Veins
Liver Failure
Hemostasis
37 Citations (Scopus)

The relation of coffee consumption to serum uric acid in Japanese men and women aged 49-76 years

Pham, N. M., Yoshida, D., Morita, M., Yin, G., Toyomura, K., Keizo, O., Takayanagi, R. & Kono, S., Dec 1 2010, In : Journal of Nutrition and Metabolism. 2010, 930757.

Research output: Contribution to journalArticle

hyperuricemia
Coffee
uric acid
Uric Acid
Hyperuricemia
37 Citations (Scopus)

The relationship of coffee and green tea consumption with high-sensitivity C-reactive protein in Japanese men and women

Maki, T., Pham, N. M., Yoshida, D., Yin, G., Keizo, O., Takayanagi, R. & Kono, S., Jun 1 2010, In : Clinical Chemistry and Laboratory Medicine. 48, 6, p. 849-854 6 p.

Research output: Contribution to journalArticle

Coffee
Tea
C-Reactive Protein
Alcohols
Alcohol Drinking
10 Citations (Scopus)
PAR-1 Receptor
Myofibrils
Vasoconstriction
Thrombin
Pulmonary Artery
18 Citations (Scopus)

Upregulation of proteinase-activated receptor-2 and increased response to trypsin in endothelial cells after exposure to oxidative stress in rat aortas

aman, M., Hirano, M., Kanaide, H. & Hirano, K., Oct 1 2010, In : Journal of Vascular Research. 47, 6, p. 494-506 13 p.

Research output: Contribution to journalArticle

PAR-2 Receptor
Trypsin
Endothelium
Aorta
Oxidative Stress
23 Citations (Scopus)

Up-regulation of type 2 iodothyronine deiodinase in dilated cardiomyopathy

Wang, Y. Y., Morimoto, S., Du, C. K., Lu, Q. W., Zhan, D. Y., Tsutsumi, T., Ide, T., Miwa, Y., Takahashi, F. & Sasaguri, T., Sep 1 2010, In : Cardiovascular research. 87, 4, p. 636-646 11 p.

Research output: Contribution to journalArticle

Iodide Peroxidase
Dilated Cardiomyopathy
Up-Regulation
Thyroid Hormones
Propylthiouracil
6 Citations (Scopus)

Usefulness of a flexible port for natural orifice transluminal endoscopic surgery by the transrectal and transvaginal routes

Ohdaira, T., Ikeda, K., Tajiri, H., Yasuda, Y. & Hashizume, M., Jun 18 2010, In : Diagnostic and Therapeutic Endoscopy. 473080.

Research output: Contribution to journalArticle

Natural Orifice Endoscopic Surgery
Laparoscopes
Equipment and Supplies
Surgical Instruments
Friction
58 Citations (Scopus)

VEGFR2 is selectively expressed by FOXP3high CD4+ Treg

Suzuki, H., Ohnishi, H., Wada, J., Yamasaki, A., Tanaka, H., Nakano, K., Morisaki, T. & Katano, M., Jan 1 2010, In : European Journal of Immunology. 40, 1, p. 197-203 7 p.

Research output: Contribution to journalArticle

Vascular Endothelial Growth Factor Receptor-2
Immune Tolerance
Neoplasm Antigens
Lymphocytes
T-Lymphocytes

非線形有限要素解析を模したニューラルネットワークを用いた軟性臓器ボリュームモデルの変形シミュレータ

Translated title of the contribution: Real-Time Nonlinear FEM-Based Simulator for Deforming Volume Model of Soft Organ by Neural Network諸岡健一, 陳献, 倉爪亮, 内田誠一, 原健二, 砂川賢二 & 橋爪誠, Mar 1 2010, In : 電子情報通信学会論文誌. D, 情報・システム = The IEICE transactions on information and systems. 93, 3, p. 365-376 12 p.

Research output: Contribution to journalArticle

2009

AdaBoostによる気道・食道自動識別

Morooka, K., Kurazume, R., Uchida, S., Hara, K., Sunagawa, K. & Hashizume, M., 2009, In : IEICE Transactions on Information and Systems. J92-D, p. 2249-2260

Research output: Contribution to journalArticle

AdaBoost による気道・食道自動識別

Translated title of the contribution: Trachea and Esophagus Classification by AdaBoost田村暁斗, 諸岡健一, 倉爪亮, 岩下友美, 内田誠一, 原健二, 中西洋一, 橋爪誠 & 長谷川勉, Dec 1 2009, In : 電子情報通信学会論文誌. D, 情報・システム = The IEICE transactions on information and systems. 92, 12, p. 2249-2260 12 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

A minimally invasive registration method using Surface Template-Assisted Marker Positioning (STAMP) for image-guided otologic surgery

Matsumoto, N., Hong, J., Hashizume, M. & Komune, S., Jan 1 2009, In : Otolaryngology - Head and Neck Surgery. 140, 1, p. 96-102 7 p.

Research output: Contribution to journalArticle

Computer-Assisted Surgery
Cochlear Implants
Preoperative Care
Bone and Bones
Acoustic Neuroma
8 Citations (Scopus)

A novel protease activity assay using a protease-responsive chaperone protein

Sao, K., Murata, M., Fujisaki, Y., Umezaki, K., Mori, T., Niidome, T., Katayama, Y. & Hashizume, M., Jun 5 2009, In : Biochemical and Biophysical Research Communications. 383, 3, p. 293-297 5 p.

Research output: Contribution to journalArticle

Assays
Peptide Hydrolases
Proteins
Factor Xa
Small Heat-Shock Proteins
5 Citations (Scopus)

A preoperative evaluation for neo-infantile liver tumors using a three-dimensional reconstruction of multidetector row CT

Kinoshita, Y., Sozaki, R., Tajiri, T., Ieiri, S., Hashizume, M. & Taguchi, T., Jun 29 2009, In : Oncology Reports. 21, 4, p. 881-886 6 p.

Research output: Contribution to journalArticle

Pediatrics
Contrast Media
Liver
Neoplasms
Residual Volume
13 Citations (Scopus)

Association of single nucleotide polymorphisms in secreted frizzled-related protein 1 gene with bone mineral density in Japanese women

Keizo, O., Yamamoto, K., Nakamura, K., Adachi, M., Kawate, H., Kono, S. & Takayanagi, R., Aug 31 2009, In : Geriatrics and Gerontology International. 9, 3, p. 304-309 6 p.

Research output: Contribution to journalArticle

Bone Density
Single Nucleotide Polymorphism
Genes
Values
Femur Neck
3 Citations (Scopus)

Cardiopulmonary arrest caused by acute abdominal aortic thrombosis: A case report

Matsuoka, Y. & Hashizume, M., Apr 28 2009, In : BMJ case reports.

Research output: Contribution to journalArticle

Heart Arrest
Aortography
Thrombosis
Aortic Diseases
Thrombectomy
52 Citations (Scopus)

Chronic kidney disease as an independent risk for long-term adverse outcomes in patients hospitalized with heart failure in Japan - Report from the Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD)

Hamaguchi, S., Tsuchihashi-Makaya, M., Kinugawa, S., Yokota, T., Ide, T., Takeshita, A. & Tsutsui, H., Aug 1 2009, In : Circulation Journal. 73, 8, p. 1442-1447 6 p.

Research output: Contribution to journalArticle

Cardiology
Chronic Renal Insufficiency
Registries
Japan
Heart Failure
167 Citations (Scopus)

Confirmation of multiple risk loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population

Takeuchi, F., Serizawa, M., Yamamoto, K., Fujisawa, T., Nakashima, E., Keizo, O., Ikegami, H., Sugiyama, T., Katsuya, T., Miyagishi, M., Nakashima, N., Nawata, H., Nakamura, J., Kono, S., Takayanagi, R. & Kato, N., Jul 1 2009, In : Diabetes. 58, 7, p. 1690-1699 10 p.

Research output: Contribution to journalArticle

Genetic Loci
Genome-Wide Association Study
Type 2 Diabetes Mellitus
Single Nucleotide Polymorphism
Population
3 Citations (Scopus)

Coronary aneurysm associated with coronary perforation after sirolimus-eluting stents implantation: Close follow-up exceeding 2 years by coronary 3-dimensional computed tomography

Eshima, K. I., Takemoto, M., Inoue, S., Higo, T., Tada, H. & Sunagawa, K., Aug 1 2009, In : Journal of Cardiology. 54, 1, p. 115-120 6 p.

Research output: Contribution to journalArticle

Coronary Aneurysm
Sirolimus
Stents
Tomography
Aneurysm