Department of Advanced Medical Initiatives

Research Output 1980 2020

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Article
2010
1 Citation (Scopus)
Conjugated (USP) Estrogens
Estrogen Replacement Therapy
Thrombosis
Hemoptysis
Fluoroscopy
40 Citations (Scopus)

Oestrogen receptor-α contributes to the regulation of the hedgehog signalling pathway in ERα-positive gastric cancer

Kameda, C., Nakamura, M., Tanaka, H., Yamasaki, A., Kubo, M., Tanaka, M., Onishi, H. & Katano, M., Feb 1 2010, In : British journal of cancer. 102, 4, p. 738-747 10 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Stomach Neoplasms
Cell Proliferation
Small Interfering RNA
Estrogens
32 Citations (Scopus)

Overexpression of mitochondrial transcription factor A (TFAM) ameliorates delayed neuronal death due to transient forebrain ischemia in mice

Hokari, M., Kuroda, S., Kinugawa, S., Ide, T., Tsutsui, H. & Iwasaki, Y., Aug 1 2010, In : Neuropathology. 30, 4, p. 401-407 7 p.

Research output: Contribution to journalArticle

Prosencephalon
Transgenic Mice
Ischemia
Common Carotid Artery
Hippocampal CA1 Region
2 Citations (Scopus)

Para-hisian pacing for a pediatric patient with a congenitally corrected transposition of the great arteries (SLL)

Takemoto, M., Nakashima, A., Muneuchi, J., Yamamura, K. I., Shiokawa, Y., Sunagawa, K. & Tominaga, R., Jan 1 2010, In : PACE - Pacing and Clinical Electrophysiology. 33, 1, p. e4-e7

Research output: Contribution to journalArticle

Ventricular Dysfunction
Bundle of His
Pediatrics
Atrioventricular Block
Mitral Valve
62 Citations (Scopus)

Phosphorylation of TRPC6 channels at Thr69 is required for anti-hypertrophic effects of phosphodiesterase 5 inhibition

Nishida, M., Watanabe, K., Sato, Y., Nakaya, M., Kitajima, N., Ide, T., Inoue, R. & Kurose, H., Apr 23 2010, In : Journal of Biological Chemistry. 285, 17, p. 13244-13253 10 p.

Research output: Contribution to journalArticle

Type 5 Cyclic Nucleotide Phosphodiesterases
Phosphorylation
Cyclic GMP-Dependent Protein Kinases
Cardiomegaly
Chemical activation
3 Citations (Scopus)

Pleomorphic ventricular tachycardia originating from Purkinje fiber network of left anterior fascicle

Yokoshiki, H., Mitsuyama, H., Watanabe, M., Sakurai, M. & Tsutsui, H., Jan 1 2010, In : Journal of Electrocardiology. 43, 5, p. 452-458 7 p.

Research output: Contribution to journalArticle

Purkinje Fibers
Bundle of His
Ventricular Tachycardia
Bundle-Branch Block
Syncope
11 Citations (Scopus)

Posterior displacement of the tibia increases in deep flexion of the knee

Fukagawa, S., Matsuda, S., Tashiro, Y., Hashizume, M. & Iwamoto, Y., Apr 2010, In : Clinical orthopaedics and related research. 468, 4, p. 1107-1114 8 p.

Research output: Contribution to journalArticle

Tibia
Knee
Interventional Magnetic Resonance Imaging
Bone and Bones
Knee Replacement Arthroplasties
8 Citations (Scopus)

Raloxifene induces nucleolar translocation of the estrogen receptor

Gushima, M., Kawate, H., Ohnaka, K., Nomura, M. & Takayanagi, R., May 5 2010, In : Molecular and Cellular Endocrinology. 319, 1-2, p. 14-22 9 p.

Research output: Contribution to journalArticle

Estrogen Receptor alpha
Estrogen Receptors
Tissue
Selective Estrogen Receptor Modulators
Organ Specificity
15 Citations (Scopus)

Real-Time 3-Dimensional Virtual Reality Navigation System with Open MRI for Breast-Conserving Surgery

Tomikawa, M., Hong, J., Shiotani, S., Tokunaga, E., Konishi, K., Ieiri, S., Tanoue, K., Akahoshi, T., Maehara, Y. & Hashizume, M., Jun 1 2010, In : Journal of the American College of Surgeons. 210, 6, p. 927-933 7 p.

Research output: Contribution to journalArticle

Segmental Mastectomy
Coloring Agents
Breast Neoplasms
Carcinoma, Intraductal, Noninfiltrating
Punctures
3 Citations (Scopus)

Relation of cigarette smoking, alcohol use, and coffee consumption to glycated hemoglobin in Japanese men and women

Maki, T., Ikeda, M., Morita, M., Ohnaka, K., Kawate, H., Adachi, M., Takayanagi, R. & Kono, S., Apr 1 2010, In : Diabetes and Metabolic Syndrome: Clinical Research and Reviews. 4, 2, p. 69-73 5 p.

Research output: Contribution to journalArticle

Coffee
Glycosylated Hemoglobin A
Smoking
Alcohols
Odds Ratio
20 Citations (Scopus)

Relation of coffee consumption and serum liver enzymes in Japanese men and women with reference to effect modification of alcohol use and body mass index

Ikeda, M., Maki, T., Yin, G., Kawate, H., Adachi, M., Ohnaka, K., Takayanagi, R. & Kono, S., Apr 30 2010, In : Scandinavian Journal of Clinical and Laboratory Investigation. 70, 3, p. 171-179 9 p.

Research output: Contribution to journalArticle

Coffee
Liver
Body Mass Index
Alcohols
Alanine Transaminase

Requisites for the remote-controlled wide-view CCD camera unit for natural orifice transluminal endoscopic surgery placed in the intraperitoneal cavity.

Ohdaira, T., Yasuda, Y. & Hashizume, M., Jan 1 2010, In : Surgical technology international. 19, p. 38-46 9 p.

Research output: Contribution to journalArticle

Natural Orifice Endoscopic Surgery
Lenses
Endoscopes
Water Supply
Anal Canal
16 Citations (Scopus)

Ribonucleotide reductase is not limiting for mitochondrial DNA copy number in mice

Ylikallio, E., Page, J. L., Xu, X., Lampinen, M., Bepler, G., Ide, T., Tyynismaa, H., Weiss, R. S. & Suomalainen, A., Dec 1 2010, In : Nucleic acids research. 38, 22, p. 8208-8218 11 p.

Research output: Contribution to journalArticle

Ribonucleotide Reductases
Mitochondrial DNA
Deoxyribonucleosides
Maintenance
Mammals
74 Citations (Scopus)

Risk factors for portal venous thrombosis after splenectomy in patients with cirrhosis and portal hypertension

Kinjo, N., Kawanaka, H., Akahoshi, T., Tomikawa, M., Yamashita, N., Konishi, K., Tanoue, K., Shirabe, K., Hashizume, M. & Maehara, Y., Jun 1 2010, In : British Journal of Surgery. 97, 6, p. 910-916 7 p.

Research output: Contribution to journalArticle

Portal Hypertension
Splenectomy
Venous Thrombosis
Fibrosis
Splenic Vein
27 Citations (Scopus)

Skills assessment using a virtual reality simulator, LapSim™, after training to develop fundamental skills for endoscopic surgery

Tanoue, K., Uemura, M., Kenmotsu, H., Ieiri, S., Konishi, K., Ohuchida, K., Onimaru, M., Nagao, Y., Kumashiro, R., Tomikawa, M. & Hashizume, M., Feb 1 2010, In : Minimally Invasive Therapy and Allied Technologies. 19, 1, p. 24-29 6 p.

Research output: Contribution to journalArticle

Feasibility Studies
Safety
Education
Surgeons

Successful salvage after necrotizing fasciitis in a lower extremity with hip and knee replacement

Tashiro, Y., Shuto, T., Yoshida, T., Sakamoto, A., Yamamoto, S., Hashizume, M. & Iwamoto, Y., Mar 1 2010, In : Current Orthopaedic Practice. 21, 2, p. 223-225 3 p.

Research output: Contribution to journalArticle

Necrotizing Fasciitis
Hip
Lower Extremity
Knee
35 Citations (Scopus)

Surface-bound TGF-β1 on effusion-derived exosomes participates in maintenance of number and suppressive function of regulatory T-cells in malignant effusions

Wada, J., Onishi, H., Suzuki, H., Yamasaki, A., Nagai, S., Morisaki, T. & Katano, M., Sep 1 2010, In : Anticancer research. 30, 9, p. 3747-3757 11 p.

Research output: Contribution to journalArticle

Exosomes
Regulatory T-Lymphocytes
Maintenance
Immunotherapy
Blood Cells
74 Citations (Scopus)

Tenascin-C may aggravate left ventricular remodeling and function after myocardial infarction in mice

Nishioka, T., Onishi, K., Shimojo, N., Nagano, Y., Matsusaka, H., Ikeuchi, M., Ide, T., Tsutsui, H., Hiroe, M., Yoshida, T. & Imanaka-Yoshida, K., Mar 1 2010, In : American Journal of Physiology - Heart and Circulatory Physiology. 298, 3, p. H1072-H1078

Research output: Contribution to journalArticle

Tenascin
Ventricular Remodeling
Left Ventricular Function
Myocardial Infarction
Myocardium
22 Citations (Scopus)

The efficacy of balloon-occluded retrograde transvenous obliteration on small intestinal variceal bleeding

Hashimoto, N., Akahoshi, T., Yoshida, D., Kinjo, N., Konishi, K., Uehara, H., Nagao, Y., Kawanaka, H., Tomikawa, M. & Maehara, Y., Jul 1 2010, In : Surgery. 148, 1, p. 145-150 6 p.

Research output: Contribution to journalArticle

Hemorrhage
Esophageal and Gastric Varices
Varicose Veins
Liver Failure
Hemostasis
37 Citations (Scopus)

The relation of coffee consumption to serum uric acid in Japanese men and women aged 49-76 years

Pham, N. M., Yoshida, D., Morita, M., Yin, G., Toyomura, K., Ohnaka, K., Takayanagi, R. & Kono, S., Dec 1 2010, In : Journal of Nutrition and Metabolism. 2010, 930757.

Research output: Contribution to journalArticle

hyperuricemia
Coffee
uric acid
Uric Acid
Hyperuricemia
37 Citations (Scopus)

The relationship of coffee and green tea consumption with high-sensitivity C-reactive protein in Japanese men and women

Maki, T., Pham, N. M., Yoshida, D., Yin, G., Ohnaka, K., Takayanagi, R. & Kono, S., Jun 1 2010, In : Clinical Chemistry and Laboratory Medicine. 48, 6, p. 849-854 6 p.

Research output: Contribution to journalArticle

Coffee
Tea
C-Reactive Protein
Alcohols
Alcohol Drinking
11 Citations (Scopus)
PAR-1 Receptor
Myofibrils
Vasoconstriction
Thrombin
Pulmonary Artery
18 Citations (Scopus)

Upregulation of proteinase-activated receptor-2 and increased response to trypsin in endothelial cells after exposure to oxidative stress in rat aortas

Aman, M., Hirano, M., Kanaide, H. & Hirano, K., Oct 1 2010, In : Journal of Vascular Research. 47, 6, p. 494-506 13 p.

Research output: Contribution to journalArticle

PAR-2 Receptor
Trypsin
Endothelium
Aorta
Oxidative Stress
24 Citations (Scopus)

Up-regulation of type 2 iodothyronine deiodinase in dilated cardiomyopathy

Wang, Y. Y., Morimoto, S., Du, C. K., Lu, Q. W., Zhan, D. Y., Tsutsumi, T., Ide, T., Miwa, Y., Takahashi-Yanaga, F. & Sasaguri, T., Sep 1 2010, In : Cardiovascular research. 87, 4, p. 636-646 11 p.

Research output: Contribution to journalArticle

Iodide Peroxidase
Dilated Cardiomyopathy
Up-Regulation
Thyroid Hormones
Propylthiouracil
6 Citations (Scopus)

Usefulness of a flexible port for natural orifice transluminal endoscopic surgery by the transrectal and transvaginal routes

Ohdaira, T., Ikeda, K., Tajiri, H., Yasuda, Y. & Hashizume, M., Jun 18 2010, In : Diagnostic and Therapeutic Endoscopy. 473080.

Research output: Contribution to journalArticle

Natural Orifice Endoscopic Surgery
Laparoscopes
Equipment and Supplies
Surgical Instruments
Friction
61 Citations (Scopus)

VEGFR2 is selectively expressed by FOXP3high CD4+ Treg

Suzuki, H., Onishi, H., Wada, J., Yamasaki, A., Tanaka, H., Nakano, K., Morisaki, T. & Katano, M., Jan 1 2010, In : European Journal of Immunology. 40, 1, p. 197-203 7 p.

Research output: Contribution to journalArticle

Vascular Endothelial Growth Factor Receptor-2
Immune Tolerance
Neoplasm Antigens
Lymphocytes
T-Lymphocytes

非線形有限要素解析を模したニューラルネットワークを用いた軟性臓器ボリュームモデルの変形シミュレータ

Translated title of the contribution: Real-Time Nonlinear FEM-Based Simulator for Deforming Volume Model of Soft Organ by Neural Network諸岡健一, 陳献, 倉爪亮, 内田誠一, 原健二, 砂川賢二 & 橋爪誠, Mar 1 2010, In : 電子情報通信学会論文誌. D, 情報・システム = The IEICE transactions on information and systems. 93, 3, p. 365-376 12 p.

Research output: Contribution to journalArticle

2009

AdaBoostによる気道・食道自動識別

Morooka, K., Kurazume, R., Uchida, S., Hara, K., Sunagawa, K. & Hashizume, M., 2009, In : IEICE Transactions on Information and Systems. J92-D, p. 2249-2260

Research output: Contribution to journalArticle

AdaBoost による気道・食道自動識別

Translated title of the contribution: Trachea and Esophagus Classification by AdaBoost田村暁斗, 諸岡健一, 倉爪亮, 岩下友美, 内田誠一, 原健二, 中西洋一, 橋爪誠 & 長谷川勉, Dec 1 2009, In : 電子情報通信学会論文誌. D, 情報・システム = The IEICE transactions on information and systems. 92, 12, p. 2249-2260 12 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

A minimally invasive registration method using Surface Template-Assisted Marker Positioning (STAMP) for image-guided otologic surgery

Matsumoto, N., Hong, J., Hashizume, M. & Komune, S., Jan 1 2009, In : Otolaryngology - Head and Neck Surgery. 140, 1, p. 96-102 7 p.

Research output: Contribution to journalArticle

Computer-Assisted Surgery
Cochlear Implants
Preoperative Care
Bone and Bones
Acoustic Neuroma
8 Citations (Scopus)

A novel protease activity assay using a protease-responsive chaperone protein

Sao, K., Murata, M., Fujisaki, Y., Umezaki, K., Mori, T., Niidome, T., Katayama, Y. & Hashizume, M., Jun 5 2009, In : Biochemical and Biophysical Research Communications. 383, 3, p. 293-297 5 p.

Research output: Contribution to journalArticle

Assays
Peptide Hydrolases
Proteins
Factor Xa
Small Heat-Shock Proteins
5 Citations (Scopus)

A preoperative evaluation for neo-infantile liver tumors using a three-dimensional reconstruction of multidetector row CT

Kinoshita, Y., Souzaki, R., Tajiri, T., Ieiri, S., Hashizume, M. & Taguchi, T., Jun 29 2009, In : Oncology reports. 21, 4, p. 881-886 6 p.

Research output: Contribution to journalArticle

Pediatrics
Contrast Media
Liver
Neoplasms
Residual Volume
13 Citations (Scopus)

Association of single nucleotide polymorphisms in secreted frizzled-related protein 1 gene with bone mineral density in Japanese women

Ohnaka, K., Yamamoto, K., Nakamura, K., Adachi, M., Kawate, H., Kono, S. & Takayanagi, R., Aug 31 2009, In : Geriatrics and Gerontology International. 9, 3, p. 304-309 6 p.

Research output: Contribution to journalArticle

Bone Density
Single Nucleotide Polymorphism
Genes
Values
Femur Neck
4 Citations (Scopus)

Cardiopulmonary arrest caused by acute abdominal aortic thrombosis: A case report

Matsuoka, Y. & Hashizume, M., Apr 28 2009, In : BMJ case reports.

Research output: Contribution to journalArticle

Heart Arrest
Aortography
Thrombosis
Aortic Diseases
Thrombectomy
53 Citations (Scopus)

Chronic kidney disease as an independent risk for long-term adverse outcomes in patients hospitalized with heart failure in Japan - Report from the Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD)

Hamaguchi, S., Tsuchihashi-Makaya, M., Kinugawa, S., Yokota, T., Ide, T., Takeshita, A. & Tsutsui, H., Aug 1 2009, In : Circulation Journal. 73, 8, p. 1442-1447 6 p.

Research output: Contribution to journalArticle

Cardiology
Chronic Renal Insufficiency
Registries
Japan
Heart Failure
169 Citations (Scopus)

Confirmation of multiple risk loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population

Takeuchi, F., Serizawa, M., Yamamoto, K., Fujisawa, T., Nakashima, E., Ohnaka, K., Ikegami, H., Sugiyama, T., Katsuya, T., Miyagishi, M., Nakashima, N., Nawata, H., Nakamura, J., Kono, S., Takayanagi, R. & Kato, N., Jul 1 2009, In : Diabetes. 58, 7, p. 1690-1699 10 p.

Research output: Contribution to journalArticle

Genetic Loci
Genome-Wide Association Study
Type 2 Diabetes Mellitus
Single Nucleotide Polymorphism
Population
3 Citations (Scopus)

Coronary aneurysm associated with coronary perforation after sirolimus-eluting stents implantation: Close follow-up exceeding 2 years by coronary 3-dimensional computed tomography

Eshima, K. I., Takemoto, M., Inoue, S., Higo, T., Tada, H. & Sunagawa, K., Aug 1 2009, In : Journal of Cardiology. 54, 1, p. 115-120 6 p.

Research output: Contribution to journalArticle

Coronary Aneurysm
Sirolimus
Stents
Tomography
Aneurysm
12 Citations (Scopus)

C-reactive protein and colorectal adenomas: Self Defense Forces Health Study

Otake, T., Uezono, K., Takahashi, R., Fukumoto, J., Tabata, S., Abe, H., Tajima, O., Mizoue, T., Ohnaka, K. & Kono, S., Aug 20 2009, In : Cancer Science. 100, 4, p. 709-714 6 p.

Research output: Contribution to journalArticle

Adenoma
C-Reactive Protein
Health
Confidence Intervals
Inflammation
15 Citations (Scopus)

Development and validation of a viscoelastic and nonlinear liver model for needle insertion

Kobayashi, Y., Onishi, A., Hoshi, T., Kawamura, K., Hashizume, M. & Fujie, M. G., Jan 1 2009, In : International Journal of Computer Assisted Radiology and Surgery. 4, 1, p. 53-63 11 p.

Research output: Contribution to journalArticle

Nonlinear Dynamics
Liver
Needles
Swine
Experiments
7 Citations (Scopus)

Development of an articulating ultrasonically activated device for laparoscopic surgery

Ogura, G., Nakamura, R., Muragaki, Y., Hashizume, M. & Iseki, H., Jan 1 2009, In : Surgical Endoscopy. 23, 9, p. 2138-2142 5 p.

Research output: Contribution to journalArticle

Laparoscopy
Equipment and Supplies
Dissection
Hand Strength
Vibration
24 Citations (Scopus)

Effect of laparoscopic splenectomy on portal hypertensive gastropathy in cirrhotic patients with portal hypertension

Anegawa, G., Kawanaka, H., Uehara, H., Akahoshi, T., Konishi, K., Yoshida, D., Kinjo, N., Hashimoto, N., Tomikawa, M., Hashizume, M. & Maehara, Y., Sep 2009, In : Journal of Gastroenterology and Hepatology (Australia). 24, 9, p. 1554-1558 5 p.

Research output: Contribution to journalArticle

Portal Hypertension
Splenectomy
Splenomegaly
Liver Diseases
Sclerotherapy
21 Citations (Scopus)

Effect of thrombopoietin on platelet counts and liver regeneration after partial hepatectomy in a rat model

Shimabukuro, R., Kawanaka, H., Tomikawa, M., Akahoshi, T., Konishi, K., Yoshida, D., Anegawa, G., Uehara, H., Hashimoto, N., Hashizume, M. & Maehara, Y., Dec 1 2009, In : Surgery today. 39, 12, p. 1054-1059 6 p.

Research output: Contribution to journalArticle

Thrombopoietin
Liver Regeneration
Hepatectomy
Platelet Count
Hepatocyte Growth Factor

Genome-wide association study between bone mineral density and SNPs in Japanese postmenopausal women

Ohnaka, K., Mar 1 2009, In : Japanese Journal of Geriatrics. 46, 2, p. 114-116 3 p.

Research output: Contribution to journalArticle

Postmenopausal Osteoporosis
Genome-Wide Association Study
Bone Density
Single Nucleotide Polymorphism
Cohort Studies
75 Citations (Scopus)

Human heart mitochondrial DNA is organized in complex catenated networks containing abundant four-way junctions and replication forks

Pohjoismäki, J. L. O., Goffart, S., Tyynismaa, H., Willcox, S., Ide, T., Kang, D., Suomalainen, A., Karhunen, P. J., Griffith, J. D., Holt, I. J. & Jacobs, H. T., Aug 7 2009, In : Journal of Biological Chemistry. 284, 32, p. 21446-21457 12 p.

Research output: Contribution to journalArticle

Complex networks
Mitochondrial DNA
Brain
Holliday Junction Resolvases
DNA Topoisomerase IV
10 Citations (Scopus)

Intracardiac echocardiography-guided cardiac tumor biopsy

Higo, T., Takemoto, M., Ogawa, K., Inoue, S., Eshima, K. I., Tada, H. & Sunagawa, K., Feb 10 2009, In : Circulation Journal. 73, 2, p. 381-383 3 p.

Research output: Contribution to journalArticle

Heart Neoplasms
Echocardiography
Biopsy
Heart Atria
Heart Ventricles
73 Citations (Scopus)

Intramuscular metabolism during low-intensity resistance exercise with blood flow restriction

Suga, T., Okita, K., Morita, N., Yokota, T., Hirabayashi, K., Horiuchi, M., Takada, S., Takahashi, T., Omokawa, M., Kinugawa, S. & Tsutsui, H., Apr 1 2009, In : Journal of Applied Physiology. 106, 4, p. 1119-1124 6 p.

Research output: Contribution to journalArticle

Exercise
Resistance Training
Phosphocreatine
Phosphates
Physiological Stress
18 Citations (Scopus)

Involvement of STIM1 in the proteinase-activated receptor 1-mediated Ca2+ influx in vascular endothelial cells

Hirano, K., Hirano, M. & Hanada, A., Oct 1 2009, In : Journal of Cellular Biochemistry. 108, 2, p. 499-507 9 p.

Research output: Contribution to journalArticle

PAR-1 Receptor
Endothelial cells
Endothelial Cells
Thrombin
Molecules
82 Citations (Scopus)

Lipopolysaccharide (LPS) increases the invasive ability of pancreatic cancer cells through the TLR4/MyD88 signaling pathway

Ikebe, M., Kitaura, Y., Nakamura, M., Tanaka, H., Yamasaki, A., Nagai, S., Wada, J., Yanai, K., Koga, K., Sato, N., Kubo, M., Tanaka, M., Onishi, H. & Katano, M., Dec 15 2009, In : Journal of Surgical Oncology. 100, 8, p. 725-731 7 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Lipopolysaccharides
Inflammation
Neoplasms
Matrix Metalloproteinases
2 Citations (Scopus)

Lung injury and renal failure caused by potassium cyanide poisoning

Matsuoka, Y., Yasuda, M. & Hashizume, M., Dec 9 2009, In : BMJ case reports.

Research output: Contribution to journalArticle

Potassium Cyanide
Cyanides
Lung Injury
Poisoning
Renal Insufficiency