Department of Advanced Medical Initiatives

Research Output 1980 2019

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Article
2018
1 Citation (Scopus)
Monocrotaline
Pulmonary Hypertension
Intravenous Administration
Nanoparticles
Pulmonary Artery
5 Citations (Scopus)

Nationwide survey of palliative care for patients with heart failure in Japan

Kuragaichi, T., Kurozumi, Y., Ohishi, S., Sugano, Y., Sakashita, A., Kotooka, N., Suzuki, M., Higo, T., Yumino, D., Takada, Y., Maeda, S., Yamabe, S., Washida, K., Takahashi, T., Ohtani, T., Sakata, Y. & Sato, Y., Jan 1 2018, In : Circulation Journal. 82, 5, p. 1336-1343 8 p.

Research output: Contribution to journalArticle

Palliative Care
Japan
Heart Failure
Terminal Care
Dexmedetomidine
Perforators
Left ventricular assist devices
Epigastric Arteries
Perforator Flap
Heart-Assist Devices
9 Citations (Scopus)

Pancreatic stellate cells reorganize matrix components and lead pancreatic cancer invasion via the function of Endo180

Koikawa, K., Ohuchida, K., Takesue, S., Ando, Y., Kibe, S., Nakayama, H., Endo, S., Abe, T., Okumura, T., Horioka, K., Sada, M., Iwamoto, C., Moriyama, T., Nakata, K., Miyasaka, Y., Ohuchida, R., Manabe, T., Ohtsuka, T., Nagai, E., Mizumoto, K. & 2 others, Hashizume, M. & Nakamura, M., Jan 1 2018, In : Cancer Letters. 412, p. 143-154 12 p.

Research output: Contribution to journalArticle

Pancreatic Stellate Cells
Pancreatic Neoplasms
Extracellular Matrix
Collagen
Endo180
3 Citations (Scopus)

Postmortem interval estimation using the animal model of postmortem gas volume changes

Iwamoto, C., Ohuchida, K., Okumura, M., Usumoto, Y., Kishimoto, J., Murata, M., Ikeda, N. & Hashizume, M., May 2018, In : Legal Medicine. 32, p. 66-70 5 p.

Research output: Contribution to journalArticle

Animal Models
Gases
Autopsy
X Ray Computed Tomography
Euthanasia
2 Citations (Scopus)

Prospective observational study in elderly patients with non-valvular atrial fibrillation: Rationale and design of the All Nippon AF In the Elderly (ANAFIE) Registry

Inoue, H., Yamashita, T., Akao, M., Atarashi, H., Ikeda, T., Okumura, K., Koretsune, Y., Shimizu, W., Tsutsui, H., Toyoda, K., Hirayama, A., Yasaka, M., Yamaguchi, T., Akishita, M., Hasebe, N., Kario, K., Mizokami, Y., Nagata, K., Nakamura, M., Terauchi, Y. & 5 others, Yamamoto, T., Teramukai, S., Kimura, T., Kaburagi, J. & Takita, A., Oct 2018, In : Journal of Cardiology. 72, 4, p. 300-306 7 p.

Research output: Contribution to journalArticle

Atrial Fibrillation
Observational Studies
Registries
Prospective Studies
Stroke

Pulmonary arterial input impedance reflects the mechanical properties of pulmonary arterial remodeling in rats with pulmonary hypertension

Nishikawa, T., Saku, K., Kishi, T., Tohyama, T., Abe, K., Oga, Y., Arimura, T., sakamoto, T., Yoshida, K., Sunagawa, K. & Tsutsui, H., Nov 1 2018, In : Life Sciences. 212, p. 225-232 8 p.

Research output: Contribution to journalArticle

Electric Impedance
Pulmonary Hypertension
Compliance
Rats
Pulmonary Artery
Open Access
Spondylosis
Spondylarthropathies
Spinal Cord Diseases
Dialysis
Dilatation and Curettage
5 Citations (Scopus)

Randomized trial of effect of urate-lowering agent febuxostat in chronic heart failure patients with hyperuricemia (LEAF-CHF) study design

Yokota, T., Fukushima, A., Kinugawa, S., Okumura, T., Murohara, T. & Tsutsui, H., Jan 1 2018, In : International heart journal. 59, 5, p. 976-982 7 p.

Research output: Contribution to journalArticle

Hyperuricemia
Uric Acid
Heart Failure
Xanthine Oxidase
Left Ventricular Function
1 Citation (Scopus)

RBPJ and MAML3: Potential therapeutic targets for small cell lung cancer

Onishi, H., Ichimiya, S., Yanai, K., Umebayashi, M., Nakamura, K., Yamasaki, A., Imaizumi, A., Nagai, S., Murahashi, M., Ogata, H. & Morisaki, T., Aug 2018, In : Anticancer research. 38, 8, p. 4543-4547 5 p.

Research output: Contribution to journalArticle

Small Cell Lung Carcinoma
gemcitabine
Therapeutics
Matrix Metalloproteinases
Pancreatic Neoplasms

"Reply to letter, More questions than answers - advanced life support interventions for out of hospital cardiac arrest"

Hagihara, A., Onozuka, D., Nagata, T. & Hasegawa, M., Mar 2018, In : American Journal of Emergency Medicine. 36, 3, p. 500-501 2 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
Spinal Cord Injuries
Knee
Sensitivity and Specificity
Cervical Cord
Leg
5 Citations (Scopus)

Sex differences in impact of coronary artery calcification to predict coronary artery disease

Nakao, Y. M., Miyamoto, Y., Higashi, M., Noguchi, T., Ohishi, M., Kubota, I., Tsutsui, H., Kawasaki, T., Furukawa, Y., Yoshimura, M., Morita, H., Nishimura, K., Kada, A., Goto, Y., Okamura, T., Tei, C., Tomoike, H., Naito, H. & Yasuda, S., Jan 1 2018, In : Heart. 104, 13, p. 1118-1124 7 p.

Research output: Contribution to journalArticle

Sex Characteristics
Coronary Artery Disease
Coronary Vessels
Coronary Angiography
Cohort Studies
2 Citations (Scopus)

Small-conductance Ca2+-activated K+ channel activation deteriorates hypoxic ventricular arrhythmias via CaMKII in cardiac hypertrophy

Tenma, T., Mitsuyama, H., Watanabe, M., Kakutani, N., Otsuka, Y., Mizukami, K., Kamada, R., Takahashi, M., Takada, S., Sabe, H., Tsutsui, H. & Yokoshiki, H., Aug 2018, In : American Journal of Physiology - Heart and Circulatory Physiology. 315, 2, p. H262-H272

Research output: Contribution to journalArticle

Calcium-Activated Potassium Channels
Calcium-Calmodulin-Dependent Protein Kinase Type 2
Cardiomegaly
Cardiac Arrhythmias
Inbred WKY Rats
1 Citation (Scopus)

The first multicenter, randomized, controlled trial of home telemonitoring for Japanese patients with heart failure: home telemonitoring study for patients with heart failure (HOMES-HF)

On Behalf Of The Homes-Hf Study Investigators, Aug 1 2018, In : Heart and Vessels. 33, 8, p. 866-876 11 p.

Research output: Contribution to journalArticle

Randomized Controlled Trials
Heart Failure
Home Care Services
Physiologic Monitoring
Registries
1 Citation (Scopus)

The impact of creating mathematical formula to predict cardiovascular events in patients with heart failure

Sakamoto, M., Fukuda, H., Kim, J., Ide, T., Kinugawa, S., Fukushima, A., Tsutsui, H., Ishii, A., Ito, S., Asanuma, H., Asakura, M., Washio, T. & Kitakaze, M., Dec 1 2018, In : Scientific reports. 8, 1, 3986.

Research output: Contribution to journalArticle

Heart Failure
Retrospective Studies
3 Citations (Scopus)

The impact of volume loading–induced low pressure baroreflex activation on arterial baroreflex-controlled sympathetic arterial pressure regulation in normal rats

Oga, Y., Saku, K., Nishikawa, T., Kishi, T., Tobushi, T., Hosokawa, K., Tohyama, T., Sakamoto, T., Sunagawa, K. & Tsutsui, H., Sep 2018, In : Physiological Reports. 6, 19, e13887.

Research output: Contribution to journalArticle

Baroreflex
Arterial Pressure
Pressure
Central Venous Pressure
Carotid Sinus
5 Citations (Scopus)

The Jarvik 2000 left ventricular assist device as a bridge to transplantation: Japanese Registry for Mechanically Assisted Circulatory Support

Kohno, H., Matsumiya, G., Sawa, Y., Ono, M., Saiki, Y., Shiose, A., Yamazaki, K., Matsui, Y., Niinami, H., Matsuda, H., Kitamura, S., Nakatani, T. & Kyo, S., Jan 2018, In : Journal of Heart and Lung Transplantation. 37, 1, p. 71-78 8 p.

Research output: Contribution to journalArticle

Heart-Assist Devices
Aortic Valve Insufficiency
Registries
Transplantation
Equipment and Supplies
Spinal Cord Compression
Spinal Cord Diseases
Radiotherapy
Radiation
Therapeutics
1 Citation (Scopus)

The novel selective pan-TRK inhibitor ONO-7579 exhibits antitumor efficacy against human gallbladder cancer in vitro

Kawamoto, M., Ozono, K., Oyama, Y., Yamasaki, A., Oda, Y. & Onishi, H., Apr 2018, In : Anticancer research. 38, 4, p. 1979-1986 8 p.

Research output: Contribution to journalArticle

Gallbladder Neoplasms
TYK2 Kinase
trkB Receptor
Phase II Clinical Trials
Clinical Trials, Phase I
Heart-Assist Devices
Cardiogenic Shock
Heart Failure
Cardiopulmonary Bypass
Transplantation
1 Citation (Scopus)

Three nights leg thermal therapy could improve sleep quality in patients with chronic heart failure

Sawatari, H., Nishizaka, M. K., Miyazono, M., Ando, S. I., Inoue, S., Takemoto, M., sakamoto, T., Goto, D., Furumoto, T., Kinugawa, S., Hashiguchi, N., Rahmawati, A., Chishaki, H., Ohkusa, T., Magota, C., Tsutsui, H. & Chishaki, A., Feb 1 2018, In : Heart and Vessels. 33, 2, p. 155-162 8 p.

Research output: Contribution to journalArticle

Leg
Sleep
Heart Failure
Hot Temperature
Therapeutics
5 Citations (Scopus)

Ultrasensitive MRI detection of spontaneous pancreatic tumors with nanocage-based targeted contrast agent

Kawano, T., Murata, M., Kang, J. H., Piao, J. S., Narahara, S., Hyodo, F., Hamano, N., Guo, J., Oguri, S., Ouchida, K. & Hashizume, M., Jan 1 2018, In : Biomaterials. 152, p. 37-46 10 p.

Research output: Contribution to journalArticle

Magnetic resonance
Contrast Media
Tumors
Magnetic Resonance Imaging
Imaging techniques

Urgent cardiac resynchronization therapy is useful in patients with decompensated heart failure requiring inotropes and mechanical circulatory support

Yakabe, D., Mukai, Y., Kawai, S., Nagaoka, K., Fujino, T., Higo, T., Chishaki, A. & Tsutsui, H., Aug 1 2018, In : Journal of Cardiology Cases. 18, 2, p. 52-56 5 p.

Research output: Contribution to journalArticle

Cardiac Resynchronization Therapy
Heart Failure
Intra-Aortic Balloon Pumping
Cardiomyopathies
Hemodynamics
2 Citations (Scopus)
Open Access
Scoliosis
Thorax
X-Rays
Prone Position
Supine Position
2017
Balloon Angioplasty
Pulmonary Hypertension
Lung
Single Photon Emission Computed Tomography Computed Tomography
2 Citations (Scopus)

Activation of ERK1/2 Causes Pazopanib Resistance via Downregulation of DUSP6 in Synovial Sarcoma Cells

Yokoyama, N., Matsunobu, T., Matsumoto, Y., Fukushi, J. I., Endo, M., Hatano, M., Nabeshima, A., Fukushima, S., Okada, S. & Iwamoto, Y., Mar 28 2017, In : Scientific reports. 7, 45332.

Research output: Contribution to journalArticle

Dual Specificity Phosphatase 6
Synovial Sarcoma
Down-Regulation
Clone Cells
Mitogen-Activated Protein Kinase Kinases
4 Citations (Scopus)

Age × Gender Interaction Effect on Resuscitation Outcomes in Patients With Out-of-Hospital Cardiac Arrest

Hagihara, A., Onozuka, D., Ono, J., Nagata, T. & Hasegawa, M., Aug 1 2017, In : American Journal of Cardiology. 120, 3, p. 387-392 6 p.

Research output: Contribution to journalArticle

Out-of-Hospital Cardiac Arrest
Resuscitation
Odds Ratio
Confidence Intervals
Survival Rate
9 Citations (Scopus)

A new innovative laparoscopic fundoplication training simulator with a surgical skill validation system

Jimbo, T., Ieiri, S., Obata, S., Uemura, M., Souzaki, R., Matsuoka, N., Katayama, T., Masumoto, K., Hashizume, M. & Taguchi, T., Apr 1 2017, In : Surgical endoscopy. 31, 4, p. 1688-1696 9 p.

Research output: Contribution to journalArticle

Fundoplication
Pediatrics
Surgical Instruments
Sutures
Ligation
1 Citation (Scopus)

A new method to estimate pulmonary vascular resistance using diastolic pulmonary artery-right ventricular pressure gradients derived from continuous-wave Doppler velocity measurements of pulmonary regurgitation

Kaga, S., Mikami, T., Murayama, M., Okada, K., Masauzi, N., Nakabachi, M., Nishino, H., Yokoyama, S., Nishida, M., Hayashi, T., Murai, D., Iwano, H., Sakakibara, M., Yamada, S. & Tsutsui, H., Jan 1 2017, In : International Journal of Cardiovascular Imaging. 33, 1, p. 31-38 8 p.

Research output: Contribution to journalArticle

Pulmonary Valve Insufficiency
Ventricular Pressure
Vascular Resistance
Pulmonary Artery
Cardiac Catheterization

A radiographic evaluation of facet sagittal angle in cervical spinal cord injury without major fracture or dislocation

Takao, T., Kubota, K., Maeda, T., Okada, S., Morishita, Y., Mori, E., Yugue, I., Kawano, O., Sakai, H., Ueta, T. & Shiba, K., May 1 2017, In : Spinal Cord. 55, 5, p. 515-517 3 p.

Research output: Contribution to journalArticle

Spinal Cord Injuries
Joints
Spine
Cervical Cord
Fracture Dislocation
10 Citations (Scopus)

Arterial pressure lability is improved by sodium-glucose cotransporter 2 inhibitor in streptozotocin-induced diabetic rats

Yoshikawa, T., Kishi, T., Shinohara, K., Takesue, K., Shibata, R., Sonoda, N., Inoguchi, T., Sunagawa, K., Tsutsui, H. & Hirooka, Y., Jul 1 2017, In : Hypertension Research. 40, 7, p. 646-651 6 p.

Research output: Contribution to journalArticle

Sodium-Glucose Transport Proteins
Streptozocin
Arterial Pressure
Insulin
Diabetes Mellitus
12 Citations (Scopus)

Association of contrast-induced nephropathy with risk of adverse clinical outcomes in patients with cardiac catheterization: From the CINC-J study

on behalf of the CINC-J study investigators, Jan 15 2017, In : International Journal of Cardiology. 227, p. 424-429 6 p.

Research output: Contribution to journalArticle

Cardiac Catheterization
Kidney
Anemia
Renal Dialysis
Creatinine
45 Citations (Scopus)

Autophagy Is Required for Activation of Pancreatic Stellate Cells, Associated With Pancreatic Cancer Progression and Promotes Growth of Pancreatic Tumors in Mice

Endo, S., Nakata, K., Ohuchida, K., Takesue, S., Nakayama, H., Abe, T., Koikawa, K., Okumura, T., Sada, M., Horioka, K., Zheng, B., Mizuuchi, Y., Iwamoto, C., Murata, M., Moriyama, T., Miyasaka, Y., Ohtsuka, T., Mizumoto, K., Oda, Y., Hashizume, M. & 1 others, Nakamura, M., May 2017, In : Gastroenterology. 152, 6, p. 1492-1506.e24

Research output: Contribution to journalArticle

Pancreatic Stellate Cells
Autophagy
Pancreatic Neoplasms
Growth
Neoplasms
11 Citations (Scopus)

Brain-derived neurotrophic factor/tropomyosin-related kinase B signaling pathway contributes to the aggressive behavior of lung squamous cell carcinoma

Ozono, K., Ohishi, Y., Onishi, H., Nakamura, K., Motoshita, J., Kato, M., Nakanishi, R., Nakamura, M. & Oda, Y., Nov 1 2017, In : Laboratory Investigation. 97, 11, p. 1332-1342 11 p.

Research output: Contribution to journalArticle

Brain-Derived Neurotrophic Factor
Squamous Cell Carcinoma
Lung
Small Interfering RNA
tropomyosin kinase

Cancer-associated peritoneal mesothelial cells lead the formation of pancreatic cancer peritoneal dissemination

Abe, T., Ohuchida, K., Koikawa, K., Endo, S., Okumura, T., Sada, M., Horioka, K., Zheng, B., Moriyama, T., Nakata, K., Miyasaka, Y., Manabe, T., Ohtsuka, T., Nagai, E., Mizumoto, K., Hashizume, M. & Nakamura, M., Feb 2017, In : International journal of oncology. 50, 2, p. 457-467 11 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Neoplasms
Collagen
Gels
Anoikis
2 Citations (Scopus)

Carotid body denervation markedly improves survival in rats with hypertensive heart failure

Fujii, K., Saku, K., Kishi, T., Oga, Y., Tohyama, T., Nishikawa, T., Sakamoto, T., Ikeda, M., Ide, T., Tsutsui, H. & Sunagawa, K., Jan 1 2017, In : American Journal of Hypertension. 30, 8, p. 791-798 8 p.

Research output: Contribution to journalArticle

Carotid Body
Denervation
Heart Failure
Survival
Natriuresis
3 Citations (Scopus)

CD24 modulates chemosensitivity of MCF-7 breast cancer cells

Onishi, H., Suyama, K., Yamasaki, A., Oyama, Y., Fujimura, A., Kawamoto, M. & Imaizumi, A., Jan 1 2017, In : Anticancer research. 37, 2, p. 561-566 6 p.

Research output: Contribution to journalArticle

Fluorouracil
Breast Neoplasms
Small Interfering RNA
Cisplatin
ATP-Binding Cassette Transporters
3 Citations (Scopus)

Central chemoreflex activation induces sympatho-excitation without altering static or dynamic baroreflex function in normal rats

Saku, K., Tohyama, T., Shinoda, M., Kishi, T., Hosokawa, K., Nishikawa, T., Oga, Y., Sakamoto, T., Tsutsui, H., Miyamoto, T. & Sunagawa, K., Sep 12 2017, In : Physiological Reports. 5, 17, e13406.

Research output: Contribution to journalArticle

Baroreflex
Pressure
Arterial Pressure
Carotid Sinus
Sympathetic Ganglia
9 Citations (Scopus)

Chd2 regulates chromatin for proper gene expression toward differentiation in mouse embryonic stem cells

Semba, Y., Harada, A., Maehara, K., Oki, S., Meno, C., Ueda, J., Yamagata, K., Suzuki, A., Onimaru, M., Nogami, J., Okada, S., Akashi, K. & Ohkawa, Y., Sep 1 2017, In : Nucleic acids research. 45, 15, p. 8758-8772 15 p.

Research output: Contribution to journalArticle

DNA Helicases
Embryonic Stem Cells
Chromatin
Gene Expression
Histones

Clinical characteristics of type A acute aortic dissection with CNS symptom

Shono, Y., Akahoshi, T., Mezuki, S., Momii, K., Kaku, N., Maki, J., Tokuda, K., Ago, T., Kitazono, T. & Maehara, Y., Dec 2017, In : American Journal of Emergency Medicine. 35, 12, p. 1836-1838 3 p.

Research output: Contribution to journalArticle

Dissection
Central Nervous System
Back Pain
Chest Pain
Blood Pressure

Clinical features and surgical management of rare cases of thoracic intraspinal cysts: Report of 3 cases

Saiwai, H., Okada, S., Miyazaki, K., Nakano, R., Iwamoto, Y. & Tsuchiya, K., May 1 2017, In : Journal of Orthopaedic Science. 22, 3, p. 578-582 5 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Comparison of weighed food record procedures for the reference methods in two validation studies of food frequency questionnaires

Ishii, Y., Ishihara, J., Takachi, R., Shinozawac, Y., Imaeda, N., Goto, C., Wakai, K., Takahashi, T., Iso, H., Nakamura, K., Tanaka, J., Shimazu, T., Yamaji, T., Sasazuki, S., Sawada, N., Iwasaki, M., Mikami, H., Kuriki, K., Naito, M., Okamoto, N. & 13 others, Kondo, F., Hosono, S., Miyagawa, N., Ozaki, E., Katsuura-Kamano, S., Ohnaka, K., Nanri, H., Tsunematsu-Nakahata, N., Kayama, T., Kurihara, A., Kojima, S., Tanaka, H. & Tsugane, S., Jan 1 2017, In : Journal of epidemiology. 27, 7, p. 331-337 7 p.

Research output: Contribution to journalArticle

Validation Studies
Food
Portion Size
Surveys and Questionnaires
Diet Records
9 Citations (Scopus)

Delayed contrast-enhanced computed tomography in patients with known or suspected cardiac sarcoidosis: A feasibility study

Aikawa, T., Oyama-Manabe, N., Naya, M., Ohira, H., Sugimoto, A., Tsujino, I., Obara, M., Manabe, O., Kudo, K., Tsutsui, H. & Tamaki, N., Oct 1 2017, In : European Radiology. 27, 10, p. 4054-4063 10 p.

Research output: Contribution to journalArticle

Feasibility Studies
Sarcoidosis
Tomography
Gadolinium
Magnetic Resonance Spectroscopy

Development of holistic cancer treatment centering cancer patients-from the standpoint of hypoxia and hedgehog signaling

Ohnishi, H., Ogino, T., Morisaki, T. & Katano, M., Nov 1 2017, In : Japanese Journal of Cancer and Chemotherapy. 44, 11, p. 977-980 4 p.

Research output: Contribution to journalArticle

Neoplasms
Tumor Microenvironment
Therapeutics
Pancreatic Neoplasms
Phenotype
3 Citations (Scopus)

Diagnosis and treatment guidelines for aberrant portal hemodynamics: The Aberrant Portal Hemodynamics Study Group supported by the Ministry of Health, Labor and Welfare of Japan

Working Subgroup for Clinical Practice Guideline for Aberrant Portal Hemodynamics *,**, Apr 2017, In : Hepatology Research. 47, 5, p. 373-386 14 p.

Research output: Contribution to journalArticle

Japan
Hemodynamics
Guidelines
Health
Research
4 Citations (Scopus)

Effect modification of green tea on the association between rice intake and the risk of diabetes mellitus: A prospective study in Japanese men and women

Hirata, A., Ohnaka, K., Tashiro, N., Wang, Z., Kohno, M., Kiyohara, C., Kono, S. & Takayanagi, R., May 1 2017, In : Asia Pacific Journal of Clinical Nutrition. 26, 3, p. 545-555 11 p.

Research output: Contribution to journalArticle

Tea
Diabetes Mellitus
Prospective Studies
Coffee
Oryza
20 Citations (Scopus)
Left Ventricular Function
Type 2 Diabetes Mellitus
Hypoglycemic Agents
Blood Pressure
Diastolic Heart Failure
6 Citations (Scopus)

Efficacy and safety of sacubitril/valsartan (LCZ696) in Japanese patients with chronic heart failure and reduced ejection fraction: Rationale for and design of the randomized, double-blind PARALLEL-HF study

Tsutsui, H., Momomura, S., Saito, Y., Ito, H., Yamamoto, K., Ohishi, T., Okino, N. & Guo, W., Sep 2017, In : Journal of Cardiology. 70, 3, p. 225-231 7 p.

Research output: Contribution to journalArticle

Heart Failure
Safety
Enalapril
Brain Natriuretic Peptide
Japan
1 Citation (Scopus)

Esophageal perforation due to blunt chest trauma: Difficult diagnosis because of coexisting severe disturbance of consciousness

Mezuki, S., Shono, Y., Akahoshi, T., Hisanaga, K., Saeki, H., Nakashima, Y., Momii, K., Maki, J., Tokuda, K. & Maehara, Y., Nov 2017, In : American Journal of Emergency Medicine. 35, 11, p. 1790.e3-1790.e5

Research output: Contribution to journalArticle

Esophageal Perforation
Consciousness
Mediastinitis
Thorax
Wounds and Injuries