Department of Advanced Medical Initiatives

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2019

Efficacy and safety of ivabradine in Japanese patients with chronic heart failure ― J-SHIFT study ―

behalf of the J-SHIFT Study Investigators, Jan 1 2019, In : Circulation Journal. 83, 10, p. 2049-2060 12 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)
3 Citations (Scopus)

Estimation of the baroreflex total loop gain by the power spectral analysis of continuous arterial pressure recordings

Mannoji, H., Saku, K., Nishikawa, T., Tohyama, T., Kamada, K., Abe, K., Sunagawa, G., Kishi, T., Sunagawa, K. & Tsutsui, H., Apr 2019, In : American Journal of Physiology - Heart and Circulatory Physiology. 316, 4, p. H828-H839

Research output: Contribution to journalArticle

1 Citation (Scopus)

Evaluation of the effect of sodium–glucose co-transporter 2 inhibition with empagliflozin on morbidity and mortality of patients with chronic heart failure and a reduced ejection fraction: rationale for and design of the EMPEROR-Reduced trial

on behalf of the EMPEROR-Reduced Trial Committees and Investigators, Executive Committee, National Coordinators, Consulting Statistician, Clinical Events Committee, Scientific Excellence Committee & Data Monitoring Committee, Oct 1 2019, In : European Journal of Heart Failure. 21, 10, p. 1270-1278 9 p.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)
Open Access
6 Citations (Scopus)
Open Access
1 Citation (Scopus)

Folding procedure to diminish type 3 endoleakage after open stent graft surgery with TEVAR extension

Onzuka, T., Furukawa, K., Tayama, E., Morita, S. & Shiose, A., Nov 1 2019, In : General thoracic and cardiovascular surgery. 67, 11, p. 999-1000 2 p.

Research output: Contribution to journalArticle

Genome-wide association study revealed novel loci which aggravate asymptomatic hyperuricaemia into gout

Kawamura, Y., Nakaoka, H., Nakayama, A., Okada, Y., Yamamoto, K., Higashino, T., Sakiyama, M., Shimizu, T., Ooyama, H., Ooyama, K., Nagase, M., Hidaka, Y., Shirahama, Y., Hosomichi, K., Nishida, Y., Shimoshikiryo, I., Hishida, A., Katsuura-Kamano, S., Shimizu, S., Kawaguchi, M. & 29 others, Uemura, H., Ibusuki, R., Hara, M., Naito, M., Takao, M., Nakajima, M., Iwasawa, S., Nakashima, H., Ohnaka, K., Nakamura, T., Stiburkova, B., Merriman, T. R., Nakatochi, M., Ichihara, S., Yokota, M., Takada, T., Saitoh, T., Kamatani, Y., Takahashi, A., Arisawa, K., Takezaki, T., Tanaka, K., Wakai, K., Kubo, M., Hosoya, T., Ichida, K., Inoue, I., Shinomiya, N. & Matsuo, H., Oct 1 2019, In : Annals of the Rheumatic Diseases. 78, 10, p. 1430-1437 8 p.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)

Geographical differences and the national meeting effect in patients with out-of-hospital cardiac arrests: A JCS–ReSS study report

behalf of the Japanese Circulation Society Resuscitation Science Study (JCS-ReSS) Group, Dec 2 2019, In : International journal of environmental research and public health. 16, 24, 5130.

Research output: Contribution to journalArticle

Open Access

Heart failure with reduced ejection fraction: comparison of patient characteristics and clinical outcomes within Asia and between Asia, Europe and the Americas

Dewan, P., Jhund, P. S., Shen, L., Petrie, M. C., Abraham, W. T., Atif Ali, M., Chen, C. H., Desai, A. S., Dickstein, K., Huang, J., Kiatchoosakun, S., Kim, K. S., Køber, L., Lai, W. T., Liao, Y., Mogensen, U. M., Oh, B. H., Packer, M., Rouleau, J. L., Shi, V. & 7 others, Sibulo, A. S., Solomon, S. D., Sritara, P., Swedberg, K., Tsutsui, H., Zile, M. R. & McMurray, J. J. V., May 2019, In : European Journal of Heart Failure. 21, 5, p. 577-587 11 p.

Research output: Contribution to journalArticle

Open Access
6 Citations (Scopus)

Hospitalization costs for patients with acute congestive heart failure in Japan

Kanaoka, K., Okayama, S., Nakai, M., Sumita, Y., Nishimura, K., Kawakami, R., Okura, H., Miyamoto, Y., Yasuda, S., Tsutsui, H., Komuro, I., Ogawa, H. & Saito, Y., Jan 1 2019, In : Circulation Journal. 83, 5, p. 1025-1031 7 p.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Hypoxia-inducible factor-1 α deletion in myeloid lineage attenuates hypoxia-induced pulmonary hypertension

Kojima, H., Tokunou, T., Takahara, Y., Sunagawa, K., Hirooka, Y., Ichiki, T. & Tsutsui, H., Apr 2019, In : Physiological Reports. 7, 7, e14025.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Implication of preoperative existence of atrial fibrillation on hemocompatibility-related adverse events during left ventricular assist device support

Imamura, T., Kinugawa, K., Ono, M., Kinoshita, O., Fukushima, N., Shiose, A., Matsui, Y., Yamazaki, K., Saiki, Y., Usui, A., Niinami, H., Matsumiya, G., Arai, H. & Sawa, Y., Jan 1 2019, In : Circulation Journal. 83, 6, p. 1286-1292 7 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Inhibition of TLR9-NF-κB-mediated sterile inflammation improves pressure overload-induced right ventricular dysfunction in rats

Yoshida, K., Abe, K., Ishikawa, M., Saku, K., Shinoda-Sakamoto, M., Ishikawa, T., Watanabe, T., Oka, M., Sunagawa, K. & Tsutsui, H., Mar 1 2019, In : Cardiovascular research. 115, 3, p. 658-668 11 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Involvement of different receptor subtypes in prostaglandin E2-induced contraction and relaxation in the lower esophageal sphincter and esophageal body

Bai, X., Ihara, E., Otsuka, Y., Tsuruta, S., Hirano, K., Tanaka, Y., Ogino, H., Hirano, M., Chinen, T., Akiho, H., Nakamura, K., Oda, Y. & Ogawa, Y., Aug 15 2019, In : European Journal of Pharmacology. 857, 172405.

Research output: Contribution to journalArticle

Japanese periodical nationwide epidemiologic survey of aberrant portal hemodynamics

Ohfuji, S., Furuichi, Y., Akahoshi, T., Kage, M., Obara, K., Hashizume, M., Matsuura, T., Fukushima, W. & Nakamura, Y., Aug 1 2019, In : Hepatology Research. 49, 8, p. 890-901 12 p.

Research output: Contribution to journalArticle

Open Access

Jarvik 2000 axial flow ventricular assist device in right single ventricle after Fontan operation

Tanoue, Y., Fujino, T., Tatewaki, H. & Shiose, A., Dec 1 2019, In : Journal of Artificial Organs. 22, 4, p. 338-340 3 p.

Research output: Contribution to journalArticle

JCS 2017/JHFS 2017 guideline on diagnosis and treatment of acute and chronic heart failure ― digest version ―

behalf of the Japanese Circulation Society and the Japanese Heart Failure Society Joint Working Group, Jan 1 2019, In : Circulation Journal. 83, 10, p. 2084-2184 101 p.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

JCS 2018 guideline on diagnosis and treatment of acute coronary syndrome

on behalf of the Japanese Circulation Society Joint Working Group, Jan 1 2019, In : Circulation Journal. 83, 5, p. 1085-1196 112 p.

Research output: Contribution to journalArticle

Open Access
12 Citations (Scopus)

Liprin-α4 as a new therapeutic target for SCLC as an upstream mediator of HIF1α

Onishi, H., Yamasaki, A., Nakamura, K., Ichimiya, S., Yanai, K., Umebayashi, M., Nagai, S. & Morisaki, T., Mar 1 2019, In : Anticancer research. 39, 3, p. 1179-1184 6 p.

Research output: Contribution to journalArticle

Mechano-chronotropic Unloading During the Acute Phase of Myocardial Infarction Markedly Reduces Infarct Size via the Suppression of Myocardial Oxygen Consumption

Sunagawa, G., Saku, K., Arimura, T., Nishikawa, T., Mannoji, H., Kamada, K., Abe, K., Kishi, T., Tsutsui, H. & Sunagawa, K., Apr 15 2019, In : Journal of Cardiovascular Translational Research. 12, 2, p. 124-134 11 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Nanoparticle incorporating Toll-like receptor 4 inhibitor attenuates myocardial ischaemia-reperfusion injury by inhibiting monocyte-mediated inflammation in mice

Fujiwara, M., Matoba, T., Koga, J-I., Okahara, A., Funamoto, D., Nakano, K., Tsutsui, H. & Egashira, K., Jun 1 2019, In : Cardiovascular research. 115, 7, p. 1244-1255 12 p.

Research output: Contribution to journalArticle

Nanoparticle incorporating Toll-like receptor 4 inhibitor attenuates myocardial ischaemia-reperfusion injury by inhibiting monocyte-mediated inflammation in mice

Fujiwara, M., Matoba, T., Koga, J. I., Okahara, A., Funamoto, D., Nakano, K., Tsutsui, H. & Egashira, K., Jun 1 2019, In : Cardiovascular research. 115, 7, p. 1244-1255 12 p.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Nationwide survey of multidisciplinary care and cardiac rehabilitation for patients with heart failure in Japan ― An analysis of the AMED-CHF study ―

Kamiya, K., Yamamoto, T., Tsuchihashi-Makaya, M., Ikegame, T., Takahashi, T., Sato, Y., Kotooka, N., Saito, Y., Tsutsui, H., Miyata, H. & Isobe, M., Jan 1 2019, In : Circulation Journal. 83, 7, p. 1546-1552 7 p.

Research output: Contribution to journalArticle

Open Access

Non-Pulmonary Vein Triggers of Atrial Fibrillation Are Likely to Arise from Low-Voltage Areas in the Left Atrium

Kawai, S., Mukai, Y., Inoue, S., Yakabe, D., Nagaoka, K., Sakamoto, K., Takase, S., Chishaki, A. & Tsutsui, H., Dec 1 2019, In : Scientific reports. 9, 1, 12271.

Research output: Contribution to journalArticle

Open Access
Open Access

Number of Cardiologists per Cardiovascular Beds and In-Hospital Mortality for Acute Heart Failure: A Nationwide Study in Japan

Kanaoka, K., Okayama, S., Nakai, M., Sumita, Y., Onoue, K., Soeda, T., Nishimura, K., Kawakami, R., Okura, H., Miyamoto, Y., Yasuda, S., Tsutsui, H., Komuro, I., Ogawa, H. & Saito, Y., Sep 17 2019, In : Journal of the American Heart Association. 8, 18, p. e012282

Research output: Contribution to journalArticle

Open Access

Outcome of patients with functional single ventricular heart after pacemaker implantation: What makes it poor, and what can we do?

Kodama, Y., Kuraoka, A., Ishikawa, Y., Nakamura, M., Ushinohama, H., Sagawa, K., Umemoto, S., Hashimoto, T., Sakamoto, I., Ohtani, K., Ide, T., Tsutsui, H. & Ishikawa, S., Dec 2019, In : Heart Rhythm. 16, 12, p. 1870-1874 5 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Pancreatic Juice Exosomal MicroRNAs as Biomarkers for Detection of Pancreatic Ductal Adenocarcinoma

Nakamura, S., Sadakari, Y., Ohtsuka, T., Okayama, T., Nakashima, Y., Gotoh, Y., Saeki, K., Mori, Y., Nakata, K., Miyasaka, Y., Onishi, H., Oda, Y., Goggins, M. & Nakamura, M., Jul 15 2019, In : Annals of Surgical Oncology. 26, 7, p. 2104-2111 8 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Patched 1-interacting Peptide Represses Fibrosis in Pancreatic Cancer to Augment the Effectiveness of Immunotherapy

Oyama, Y., Onishi, H., Koga, S., Murahashi, M., Ichimiya, S., Nakayama, K., Fujimura, A., Kawamoto, M., Imaizumi, A., Umebayashi, M., Ohuchida, K., Morisaki, T. & Nakamura, M., Jan 1 2019, (Accepted/In press) In : Journal of Immunotherapy.

Research output: Contribution to journalArticle

Pectoral Muscle Atrophy After Axillary Artery Cannulation for Aortic Arch Surgery

Imasaka, K. I., Tomita, Y., Nishijima, T., Tayama, E., Morita, S., Toriya, R. & Shiose, A., Sep 1 2019, In : Seminars in Thoracic and Cardiovascular Surgery. 31, 3, p. 414-421 8 p.

Research output: Contribution to journalArticle

Peripartum management of pregnant women with congenital heart disease

Yamasaki, K., Sawatari, H., Konagai, N., Kamiya, C. A., Yoshimatsu, J., Muneuchi, J., Watanabe, M., Fukuda, T., Mizuno, A., Sakamoto, I., Yamamura, K., Ohkusa, T., Tsutsui, H., Niwa, K. & Chishaki, A., Jan 1 2019, In : Circulation Journal. 83, 11, p. 2257-2264 8 p.

Research output: Contribution to journalArticle

Open Access

Peroxisome proliferator-activated receptor-gamma targeting nanomedicine promotes cardiac healing after acute myocardial infarction by skewing monocyte/macrophage polarization in preclinical animal models

Tokutome, M., Matoba, T., Nakano, Y., Okahara, A., Fujiwara, M., Koga, J. I., Nakano, K., Tsutsui, H. & Egashira, K., Feb 1 2019, In : Cardiovascular research. 115, 2, p. 419-431 13 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Possible associations between palliative care conferences and positive outcomes when performing palliative care for patients with end-stage heart failure: a nationwide cross-sectional questionnaire survey

Kurozumi, Y., Oishi, S., Sugano, Y., Sakashita, A., Kotooka, N., Suzuki, M., Higo, T., Yumino, D., Takada, Y., Maeda, S., Yamabe, S., Washida, K., Takahashi, T., Ohtani, T., Sakata, Y. & Sato, Y., Mar 15 2019, In : Heart and Vessels. 34, 3, p. 452-461 10 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Predictive value of the induction test with atrial burst pacing with regard to long-term recurrence after ablation in persistent atrial fibrillation

Kawai, S., Mukai, Y., Inoue, S., Yakabe, D., Nagaoka, K., Sakamoto, K., Takase, S., Chishaki, A. & Tsutsui, H., Apr 1 2019, In : journal of arrhythmia. 35, 2, p. 223-229 7 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Prescription rates of guideline-directed medications are associated with in-hospital mortality among Japanese patients with acute myocardial infarction: A report from JROAD-DPC study

Nakao, K., Yasuda, S., Nishimura, K., Noguchi, T., Nakai, M., Miyamoto, Y., Sumita, Y., Shishido, T., Anzai, T., Ito, H., Tsutsui, H., Saito, Y., Komuro, I. & Ogawa, H., Jan 1 2019, In : Journal of the American Heart Association. 8, 7, e009692.

Research output: Contribution to journalArticle

Open Access

Primary percutaneous coronary intervention in elderly patients with acute myocardial infarction — An analysis from a Japanese nationwide claim-based database

Uemura, S., Okamoto, H., Nakai, M., Nishimura, K., Miyamoto, Y., Yasuda, S., Tanaka, N., Kohsaka, S., Kadota, K., Saito, Y., Tsutsui, H., Komuro, I., Ikari, Y., Ogawa, H. & Nakamura, M., Jan 1 2019, In : Circulation Journal. 83, 6, p. 1229-1238 10 p.

Research output: Contribution to journalArticle

Open Access

Primary pericardial mesothelioma presenting as constrictive pericarditis

Yamamoto, T., Ohtani, K., Tanoue, Y., Shiose, A. & Tsutsui, H., May 1 2019, In : European heart journal cardiovascular Imaging. 20, 5, 1 p.

Research output: Contribution to journalArticle

Prior exposure to placental ischemia causes increased salt sensitivity of blood pressure via vasopressin production and secretion in postpartum rats

Matsuura, T., Shinohara, K., Iyonaga, T., Hirooka, Y. & Tsutsui, H., Aug 1 2019, In : Journal of hypertension. 37, 8, p. 1657-1667 11 p.

Research output: Contribution to journalArticle

Proteinase-activated receptor 1 antagonism ameliorates experimental pulmonary hypertension

Kuwabara, Y., Tanaka-Ishikawa, M., Abe, K., Hirano, M., Hirooka, Y., Tsutsui, H., Sunagawa, K. & Hirano, K., Jul 1 2019, In : Cardiovascular research. 115, 8, p. 1357-1368 12 p.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

PTPN3 expressed in activated T lymphocytes is a candidate for a non-antibody-type immune checkpoint inhibitor

Fujimura, A., Nakayama, K., Imaizumi, A., Kawamoto, M., Oyama, Y., Ichimiya, S., Umebayashi, M., Koya, N., Morisaki, T., Nakagawa, T. & Onishi, H., Oct 1 2019, In : Cancer Immunology, Immunotherapy. 68, 10, p. 1649-1660 12 p.

Research output: Contribution to journalArticle

Public-access defibrillation and neurological outcomes in patients with out-of-hospital cardiac arrest in Japan: a population-based cohort study

Japanese Circulation Society with Resuscitation Science Study Group, Dec 21 2019, In : The Lancet. 394, 10216, p. 2255-2262 8 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2 Citations (Scopus)
1 Citation (Scopus)

Standard cardiac rehabilitation program for heart failure

Izawa, H., Yoshida, T., Ikegame, T., Izawa, K. P., Ito, Y., Okamura, H., Osada, N., Kinugawa, S., Kubozono, T., Kono, Y., Kobayashi, K., Nishigaki, K., Higo, T., Hirashiki, A., Miyazawa, Y., Morio, Y., Yanase, M., Yamada, S., Ikeda, H., Momomura, S. I. & 4 others, Kihara, Y., Yamamoto, K., Goto, Y. & Makita, S., Jan 1 2019, In : Circulation Journal. 83, 12, p. 2394-2398 5 p.

Research output: Contribution to journalArticle

Open Access

Suppressed baroreflex peripheral arc overwhelms augmented neural arc and incapacitates baroreflex function in rats with pulmonary arterial hypertension

Shinoda, M., Saku, K., Oga, Y., Tohyama, T., Nishikawa, T., Abe, K., Yoshida, K., Kuwabara, Y., Fujii, K., Ishikawa, T., Kishi, T., Sunagawa, K. & Tsutsui, H., Aug 1 2019, In : Experimental Physiology. 104, 8, p. 1164-1178 15 p.

Research output: Contribution to journalArticle

The evolution of surgical treatment for gastrointestinal cancers

Maehara, Y., Soejima, Y., Yoshizumi, T., Kawahara, N., Oki, E., Saeki, H., Akahoshi, T., Ikegami, T., Yamashita, Y. I., Furuyama, T., Sugimachi, K., Harada, N., Tagawa, T., Harimoto, N., Itoh, S., Sonoda, H., Ando, K., Nakashima, Y., Nagao, Y., Yamashita, N. & 17 others, Kasagi, Y., Yukaya, T., Kurihara, T., Tsutsumi, R., Takamori, S., Sasaki, S., Ikeda, T., Yonemitsu, Y., Fukuhara, T., Kitao, H., Iimori, M., Kataoka, Y., Wakasa, T., Suzuki, M., Teraishi, K., Yoshida, Y. & Mori, M., Nov 1 2019, In : International Journal of Clinical Oncology. 24, 11, p. 1333-1349 17 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Thoracic endografting increases cardiac afterload and leads to left ventricular hypertrophy in dogs

Yamashita, Y., Oishi, Y., Motomatsu, Y., Hirayama, K., Harada, T., Ushijima, T., Fujita, S., Kimura, S., Sonoda, H., Tatewaki, H., Tanoue, Y., Sunagawa, G., Nishikawa, T., Saku, K. & Shiose, A., Apr 1 2019, In : European Journal of Cardio-thoracic Surgery. 55, 4, p. 618-625 8 p.

Research output: Contribution to journalArticle