Department of Advanced Medical Initiatives

Research Output 1980 2020

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1997
22 Citations (Scopus)

Negative inotropic effect of basic fibroblast growth factor on adult rat cardiac myocyte

Ishibashi, Y., Urabe, Y., Tsutsui, H., Kinugawa, S., Sugimachi, M., Takahashi, M., Yamamoto, S., Tagawa, H., Sunagawa, K. & Takeshita, A., Oct 21 1997, In : Circulation. 96, 8, p. 2501-2504 4 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factor 2
Cardiac Myocytes
Systole
Platelet-Derived Growth Factor
Graft Rejection

Nonspecific inflammatory stenosis of the rectum; report of a resected case

Ohnishi, H., Oohata, Y., Mibu, R., Yao, T., Nakafusa, Y., Aoyagi, K. & Tanaka, M., Jan 1 1997, In : Journal of the Japan Society of Colo-Proctology. 50, 2, p. 120-124 5 p.

Research output: Contribution to journalArticle

Rectum
Pathologic Constriction
Proctitis
Inflammation
Suppositories
57 Citations (Scopus)

Regulation of fibrillar collagen gene expression and protein accumulation in volume-overloaded cardiac hypertrophy

Namba, T., Tsutsui, H., Tagawa, H., Takahashi, M., Saito, K., Kozai, T., Usui, M., Imanaka-Yoshida, K., Imaizumi, T. & Takeshita, A., Jan 1 1997, In : Circulation. 95, 10, p. 2448-2454 7 p.

Research output: Contribution to journalArticle

Fibrillar Collagens
Cardiomegaly
Collagen
Gene Expression
Collagen Type III
71 Citations (Scopus)

Role of myocyte nitric oxide in β-adrenergic hyporesponsiveness in heart failure

Yamamoto, S., Tsutsui, H., Tagawa, H., Saito, K., Takahashi, M., Tada, H., Yamamoto, M., Katoh, M., Egashira, K. & Takeshita, A., Jan 1 1997, In : Circulation. 95, 5, p. 1111-1114 4 p.

Research output: Contribution to journalArticle

Adrenergic Agents
Muscle Cells
Nitric Oxide
Heart Failure
NG-Nitroarginine Methyl Ester
15 Citations (Scopus)
Aortic Valve
Anatomy
Ventricular Outflow Obstruction
Atrioventricular Septal Defect
2 Citations (Scopus)

The use of a newly developed pediatric arterial perfusion cannula for neonates

Asou, T., Yasui, H., Kado, H., Imoto, Y., Shiokawa, Y., Fukae, K., Tominaga, R. & Kawachi, Y., Dec 1 1997, In : Cardiology in the Young. 7, 1, p. 71-73 3 p.

Research output: Contribution to journalArticle

Perfusion
Newborn Infant
Pediatrics
Thoracic Aorta
Thoracic Surgery
1998
36 Citations (Scopus)

A long-term follow-up study on risk factors for hepatocellular carcinoma among Japanese patients with liver cirrhosis

Tanaka, K., Sakai, H., Hashizume, M. & Hirohata, T., Jan 1 1998, In : Japanese Journal of Cancer Research. 89, 12, p. 1241-1250 10 p.

Research output: Contribution to journalArticle

Liver Cirrhosis
Hepatocellular Carcinoma
Hepatitis B Surface Antigens
Genotype
Hepatitis C Antibodies
1 Citation (Scopus)

Big endothelin analogues with inhibitory activity on endothelin-converting enzyme-1

Takayanagi, R., Liu, W., Ito, T., Ohnaka, K. & Nawata, H., Jan 1 1998, In : Journal of Cardiovascular Pharmacology. 31, SUPPL. 1, p. S62-S63

Research output: Contribution to journalArticle

Endothelin-1
Endothelin-Converting Enzymes
CHO Cells
Enzyme Inhibitors
Membranes
58 Citations (Scopus)

Clinical results of the staged Fontan procedure in high-risk patients

Masuda, M., Kado, H., Shiokawa, Y., Fukae, K., Suzuki, M., Murakami, E. & Yasui, H., Jul 18 1998, In : Annals of Thoracic Surgery. 65, 6, p. 1721-1725 5 p.

Research output: Contribution to journalArticle

Fontan Procedure
Pulmonary Artery
Arterial Pressure
Scimitar Syndrome
Lung
22 Citations (Scopus)

Early experience of endoscopic extirpation of benign breast tumors via an extra-mammary incision

Kitamura, K., Hashizume, M., Sugimachi, K., Kataoka, A., Ohno, S., Kuwano, H. & Maehara, Y., Sep 1 1998, In : American Journal of Surgery. 176, 3, p. 235-238 4 p.

Research output: Contribution to journalArticle

Breast
Breast Neoplasms
Cosmetics
Intraductal Papilloma
Subcutaneous Emphysema
2 Citations (Scopus)

Giant gastric varices after a left gastric venous caval shunt operation for esophageal varices: A case report

Saeki, H., Hashizume, M., Yanaga, K., Ohta, M., Kawanaka, H., Kishihara, F., Tsugawa, Y., Migo, S. & Sugimachi, K., Jul 22 1998, In : Hepato-gastroenterology. 45, 21, p. 700-704 5 p.

Research output: Contribution to journalArticle

Venae Cavae
Esophageal and Gastric Varices
Stomach
Veins
Theft
121 Citations (Scopus)

Intramural delivery of a specific tyrosine kinase inhibitor with biodegradable stent suppresses the restenotic changes of the coronary artery in pigs in vivo

Yamawaki, T., Shimokawa, H., Kozai, T., Miyata, K., Higo, T., Tanaka, E., Egashira, K., Shiraishi, T., Tamai, H., Igaki, K. & Takeshita, A., Sep 1 1998, In : Journal of the American College of Cardiology. 32, 3, p. 780-786 7 p.

Research output: Contribution to journalArticle

Protein-Tyrosine Kinases
Stents
Coronary Vessels
Swine
Coronary Stenosis
10 Citations (Scopus)

Jejunal variceal bleeding after esophageal transection in a patient with idiopathic portal hypertension

Migou, S. I., Hashizume, M., Tsugawa, K., Kishihara, F., Kawanaka, H., Ohta, M., Tanoue, K., Kuroiwa, T., Kawamoto, K. & Sugimachi, K., Apr 27 1998, In : Hepato-gastroenterology. 45, 20, p. 503-507 5 p.

Research output: Contribution to journalArticle

Hemorrhage
Varicose Veins
Small Intestine
Lower Gastrointestinal Tract
Esophageal and Gastric Varices
19 Citations (Scopus)

Laparascopic splenectomy for an inflammatory pseudotumor of the spleen: Operative technique and case report

Tsugawa, K., Hashizume, M., Migou, S., Kawanaka, H., Sugimachi, K., Irie, H., Maeda, T. & Akaboshi, K., Jan 1 1998, In : Hepato-gastroenterology. 45, 23, p. 1887-1891 5 p.

Research output: Contribution to journalArticle

Plasma Cell Granuloma
Splenectomy
Spleen
Hemangioma
Ultrasonography
48 Citations (Scopus)

Laparoscopic gastric devascularization and splenectomy for sclerotherapyo-resistant esophagogastric varices with hypersplenism

Hashizume, M., Tanoue, K., Morita, M., Ohta, M., Tomikawa, M. & Sugimachi, K., Oct 3 1998, In : Journal of the American College of Surgeons. 187, 3, p. 263-270 8 p.

Research output: Contribution to journalArticle

Hypersplenism
Varicose Veins
Splenectomy
Stomach
Sclerotherapy
11 Citations (Scopus)

Laparoscopic repair of a paraesophageal hiatal hernia with gastric volvulus

Kuwano, H., Hashizume, M., Ohta, M., Sumiyoshi, K., Sugimachi, K. & Haraguchi, Y., Feb 19 1998, In : Hepato-gastroenterology. 45, 19, p. 303-306 4 p.

Research output: Contribution to journalArticle

Stomach Volvulus
Hiatal Hernia
Laparoscopy
Pressure
Recurrence
4 Citations (Scopus)

Laparoscopic repair of a perforated duodenal ulcer in two patients

Kabashima, A., Maehara, Y., Hashizume, M., Tomoda, M., Kakeji, Y., Ohno, S. & Sugimachi, K., Jul 2 1998, In : Surgery today. 28, 6, p. 633-635 3 p.

Research output: Contribution to journalArticle

Duodenal Ulcer
Hepatocellular Carcinoma
Lung Neoplasms
Diabetes Mellitus
Asthma
15 Citations (Scopus)

Laparoscopic splenectomy with the newly devised morcellator

Hashizume, M., Migo, S., Tsugawa, K., Tanoue, K., Ohta, M. & Sugimachi, K., Apr 27 1998, In : Hepato-gastroenterology. 45, 20, p. 554-557 4 p.

Research output: Contribution to journalArticle

Splenectomy
Spleen
Skin
Abdominal Cavity
Abdomen
1 Citation (Scopus)

Long-term Results of Corticosteroid Administration via Appendicostomy in Patients with Ulcerative Colitis Involving the Entire Colon

Tateishi, M., Takano, H., Hashizume, M., Kabashima, A. & Sugimachi, K., Jul 1 1998, In : International Surgery. 83, 3, p. 235-240 6 p.

Research output: Contribution to journalArticle

Ulcerative Colitis
Adrenal Cortex Hormones
Colon
Steroids
Fistula
29 Citations (Scopus)

Mixed type of total anomalous pulmonary venous connection

Imoto, Y., Kado, H., Asou, T., Shiokawa, Y., Tominaga, R. & Yasui, H., Oct 1 1998, In : Annals of Thoracic Surgery. 66, 4, p. 1394-1397 4 p.

Research output: Contribution to journalArticle

Pulmonary Veins
Lung
Cardiac Catheterization
Drainage
Heart Failure
6 Citations (Scopus)

Portal hypertensive gastropathy due to chronic portal vein occlusion in Crohn's disease

Yada, S., Hizawa, K., Aoyagi, K., Hashizume, M., Matsumoto, T., Koga, H. & Fujishima, M., Aug 1998, In : American Journal of Gastroenterology. 93, 8, p. 1376-1377 2 p.

Research output: Contribution to journalArticle

Portal Vein
Crohn Disease
28 Citations (Scopus)

Role of microtubules in the contractile dysfunction of myocytes from tachycardia-induced dilated cardiomyopathy

Takahashi, M., Tsutsui, H., Kinugawa, S., Igarashi-Saito, K., Yamamoto, S., Yamamoto, M., Tagawa, H., Imanaka-Yoshida, K., Egashira, K. & Takeshita, A., Jan 1 1998, In : Journal of Molecular and Cellular Cardiology. 30, 5, p. 1047-1057 11 p.

Research output: Contribution to journalArticle

Dilated Cardiomyopathy
Tubulin
Tachycardia
Microtubules
Muscle Cells
31 Citations (Scopus)

Role of microtubules in the viscoelastic properties of isolated cardiac muscle

Yamamoto, S., Tsutsui, H., Takahashi, M., Ishibashi, Y., Tagawa, H., Imanaka-Yoshida, K., Saeki, Y. & Takeshita, A., Jan 1 1998, In : Journal of Molecular and Cellular Cardiology. 30, 9, p. 1841-1853 13 p.

Research output: Contribution to journalArticle

Microtubules
Myocardium
Muscle Cells
Paclitaxel
Cytoskeleton
5 Citations (Scopus)

Role of SR Ca2+-ATPase in contractile dysfunction of myocytes in tachycardia-induced heart failure

Igarashi-Saito, K., Tsutsui, H., Yamamoto, S., Takahashi, M., Kinugawa, S., Tagawa, H., Usui, M., Yamamoto, M., Egashira, K. & Takeshita, A., Jul 1 1998, In : American Journal of Physiology - Heart and Circulatory Physiology. 44, 1

Research output: Contribution to journalArticle

Calcium-Transporting ATPases
Sarcoplasmic Reticulum
Tachycardia
Muscle Cells
Heart Failure
17 Citations (Scopus)

Role of SR Ca 2+ -ATPase in contractile dysfunction of myocytes in tachycardia-induced heart failure

Igarashi-Saito, K., Tsutsui, H., Yamamoto, S., Takahashi, M., Kinugawa, S., Agawa, H., Usui, M., Yamamoto, M., Egashira, K. & Takeshita, A., Dec 1 1998, In : American Journal of Physiology. 275, 1 PART 2

Research output: Contribution to journalArticle

Tachycardia
Muscle Cells
Adenosine Triphosphatases
Heart Failure
Messenger RNA
10 Citations (Scopus)

The clinical management and results of surgery for acute cholecystitis

Hashizume, M., Sugimachi, K. & MacFadyen, B. V., Dec 1 1998, In : Surgical Innovation. 5, 2, p. 69-80 12 p.

Research output: Contribution to journalArticle

Acute Cholecystitis
Laparotomy
Laparoscopic Cholecystectomy
Cholecystectomy
Gallbladder
4 Citations (Scopus)

The surgical anatomy of the left ventricular outflow tract in hearts with ventricular septal defect and aortic arch obstruction

Shiokawa, Y. & Becker, A. E., May 1 1998, In : Annals of Thoracic Surgery. 65, 5, p. 1381-1387 7 p.

Research output: Contribution to journalArticle

Ventricular Heart Septal Defects
Thoracic Aorta
Anatomy
Pathologic Constriction
Heart Ventricles
20 Citations (Scopus)

Transaxillary approach for the endoscopic extirpation of benign breast tumors

Kitamura, K., Hashizume, M., Kataoka, A., Ohno, S., Kuwano, H., Maehara, Y. & Sugimachi, K., Jan 1 1998, In : Surgical Laparoscopy, Endoscopy and Percutaneous Techniques. 8, 4, p. 277-279 3 p.

Research output: Contribution to journalArticle

Breast
Breast Neoplasms
Cosmetics
Equipment and Supplies
Fibroadenoma
1999
9 Citations (Scopus)
Escin
Guanosine
Guanosine Triphosphate
Adrenergic Receptors
Rats
58 Citations (Scopus)

Amiodarone protects cardiac myocytes against oxidative injury by its free radical scavenging action

Ide, T., Tsutsui, H., Kinugawa, S., Utsumi, H. & Takeshita, A., Aug 17 1999, In : Circulation. 100, 7, p. 690-692 3 p.

Research output: Contribution to journalArticle

Amiodarone
Cardiac Myocytes
Free Radicals
Wounds and Injuries
Reactive Oxygen Species
4 Citations (Scopus)

Antifibrinolytic therapy with tranexamic acid in cardiac operations

Matsuzaki, K., Matsui, K., Tanoue, Y., Nagano, I., Haraguchi, N. & Tatewaki, H., Mar 1999, In : Vascular. 7, 2, p. 195-199 5 p.

Research output: Contribution to journalArticle

Tranexamic Acid
Antifibrinolytic Agents
Cardiopulmonary Bypass
Postoperative Hemorrhage
Fibrinolysin
25 Citations (Scopus)

A selective cyclo-oxygenase-2 inhibitor, NS-398, may improve portal hypertension without inducing gastric mucosal injury

Tsugawa, K., Hashizume, M., Migou, S., Kishihara, F., Kawanaka, H., Tomikawa, M. & Sugimachi, K., Jan 1 1999, In : Journal of Gastroenterology and Hepatology (Australia). 14, 7, p. 642-651 10 p.

Research output: Contribution to journalArticle

Cyclooxygenase Inhibitors
Portal Hypertension
Stomach
Portal Pressure
Wounds and Injuries
18 Citations (Scopus)

Chronic colchicine administration attenuates cardiac hypertrophy in spontaneously hypertensive rats

Tsutsui, H., Ishibashi, Y., Takahashi, M., Namba, T., Tagawa, H., Imanaka-Yoshida, K. & Takeshita, A., Jan 1 1999, In : Journal of Molecular and Cellular Cardiology. 31, 6, p. 1203-1213 11 p.

Research output: Contribution to journalArticle

Colchicine
Cardiomegaly
Inbred SHR Rats
Microtubules
Body Weight
25 Citations (Scopus)

Clinical results of arterial switch operation for double-outlet right ventricle with subpulmonary VSD

Masuda, M., Kado, H., Shiokawa, Y., Fukae, K., Kanegae, Y., Kawachi, Y., Morita, S. & Yasui, H., Mar 22 1999, In : European Journal of Cardio-thoracic Surgery. 15, 3, p. 283-288 6 p.

Research output: Contribution to journalArticle

Double Outlet Right Ventricle
Ventricular Heart Septal Defects
Ventricular Outflow Obstruction
Arteries
Pulmonary Artery
30 Citations (Scopus)

Clinical results of mitral valve repair by reconstructing artificial chordae tendineae in children

Matsumoto, T., Kado, H., Masuda, M., Shiokawa, Y., Fukae, K., Morita, S. & Yasui, H., Jan 1 1999, In : Journal of Thoracic and Cardiovascular Surgery. 118, 1, p. 94-98 5 p.

Research output: Contribution to journalArticle

Chordae Tendineae
Mitral Valve
Mitral Valve Insufficiency
Echocardiography
Prolapse
2 Citations (Scopus)

Clinical results of mitral valve surgery in children

Masuda, M., Kado, H., Imoto, Y., Shiokawa, Y., Fukae, K., Kanegae, Y., Iwaki, H., Shirota, T., Morita, S., Tominaga, R. & Yasui, H., Jan 1 1999, In : Kyobu geka. The Japanese journal of thoracic surgery. 52, 4, p. 301-306 6 p.

Research output: Contribution to journalArticle

Mitral Valve
Reoperation
Mitral Valve Stenosis
Prolapse
Mitral Valve Insufficiency
10 Citations (Scopus)

Coil embolization of arterioportal fistula that developed after partial gastrectomy

Ishigami, K., Yoshimitsu, K., Honda, H., Kuroiwa, T., Irie, H., Aibe, H., Tajima, T., Hashizume, M. & Masuda, K., Jul 1 1999, In : CardioVascular and Interventional Radiology. 22, 4, p. 328-330 3 p.

Research output: Contribution to journalArticle

Portal Hypertension
Gastrectomy
Fistula
Esophageal and Gastric Varices
Stainless Steel
1 Citation (Scopus)

Descending aorta perfusion through median sternotomy in primary repair of aortic interruption complex

Imoto, Y., Kado, H., Shiokawa, Y., Kanegae, Y., Fukae, K., Iwaki, H., Sonoda, H., Minami, K. & Yasui, H., Jan 1 1999, In : Kyobu geka. The Japanese journal of thoracic surgery. 52, 5, p. 372-375 4 p.

Research output: Contribution to journalArticle

Sternotomy
Thoracic Aorta
Extracorporeal Circulation
Perfusion
Brachiocephalic Trunk
2 Citations (Scopus)

Efficacy of intravenous administration of atrial natriuretic peptide after cardiac surgery in neonates and infants

Murakami, E., Kado, H., Masuda, M., Shiokawa, Y., Fukae, K., Kanegae, Y., Iwaki, H., Shirota, T. & Yasui, H., Jan 1 1999, In : Kyobu geka. The Japanese journal of thoracic surgery. 52, 10, p. 822-825 4 p.

Research output: Contribution to journalArticle

Atrial Natriuretic Factor
Intravenous Administration
Thoracic Surgery
Furosemide
Newborn Infant
14 Citations (Scopus)

Endocardial versus epicardial differences of sarcoplasmic reticulum Ca2+-ATPase gene expression in the canine failing myocardium

Igarashi-Saito, K., Tsutsui, H., Takahashi, M., Kinugawa, S., Egashira, K. & Takeshita, A., Aug 1 1999, In : Basic Research in Cardiology. 94, 4, p. 267-273 7 p.

Research output: Contribution to journalArticle

Calcium-Transporting ATPases
Sarcoplasmic Reticulum
Canidae
Myocardium
Gene Expression
26 Citations (Scopus)

Endothelial vasodilator function is preserved at the spastic/inflammatory coronary lesions in pigs

Miyata, K., Shimokawa, H., Yamawaki, T., Kunihiro, I., Zhou, X., Higo, T., Tanaka, E., Katsumata, N., Egashira, K. & Takeshita, A., Sep 28 1999, In : Circulation. 100, 13, p. 1432-1437 6 p.

Research output: Contribution to journalArticle

Muscle Spasticity
Vasodilator Agents
Swine
Interleukin-1
Endothelium
14 Citations (Scopus)

Laparoscopic splenectomy: The latest modern technique

Hashizume, M., Tanoue, K., Akahoshi, T., Morita, M., Ohta, M., Tomikawa, M. & Sugimachi, K., May 25 1999, In : Hepato-gastroenterology. 46, 26, p. 820-824 5 p.

Research output: Contribution to journalArticle

Splenectomy
Portal Hypertension
Spleen
Splenic Vein
Conversion to Open Surgery
9 Citations (Scopus)

Laparoscopic splenectomy for splenic artery aneurysm

Tsugawa, K., Hashizume, M., Tomikawa, M., Tanoue, K., Migou, S. & Sugimachi, K., Oct 7 1999, In : Hepato-gastroenterology. 46, 28, p. 2631-2634 4 p.

Research output: Contribution to journalArticle

Splenic Artery
Splenectomy
Aneurysm
Abdomen
Laparotomy
17 Citations (Scopus)

Leiomyosarcoma of the thyroid gland with rapid growth and tracheal obstruction: A partial thyroidectomy and tracheostomy using an ultrasonically activated scalpel can be safely performed with less bleeding.

Tsugawa, K., Koyanagi, N., Nakanishi, K., Wada, H., Tanoue, K., Hashizume, M. & Sugimachi, K., Nov 22 1999, In : European journal of medical research. 4, 11, p. 483-487 5 p.

Research output: Contribution to journalArticle

Leiomyosarcoma
Tracheostomy
Thyroidectomy
Thyroid Gland
Hemorrhage
1 Citation (Scopus)

Malignant lymphoma with c-myc gene rearrangement in a patient receiving long-term treatment for multiple myeloma

Ohnishi, H., Kamimura, T., Gondo, H., Okamura, T., Niho, Y. & Yao, T., Dec 1999, In : [Rinshō ketsueki] The Japanese journal of clinical hematology. 40, 12, p. 1265-1270 6 p.

Research output: Contribution to journalArticle

myc Genes
Gene Rearrangement
Multiple Myeloma
Lymphoma
Drug Therapy
528 Citations (Scopus)

Mitochondrial electron transport complex I is a potential source of oxygen free radicals in the failing myocardium

Ide, T., Tsutsui, H., Kinugawa, S., Utsumi, H., Kang, D., Hattori, N., Uchida, K., Arimura, K. I., Egashira, K. & Takeshita, A., Aug 20 1999, In : Circulation research. 85, 4, p. 357-363 7 p.

Research output: Contribution to journalArticle

Electron Transport Complex I
Free Radicals
Reactive Oxygen Species
Myocardium
Heart Failure
56 Citations (Scopus)

Norwood procedure without circulatory arrest

Imoto, Y., Kado, H., Shiokawa, Y., Fukae, K. & Yasui, H., Aug 1 1999, In : Annals of Thoracic Surgery. 68, 2, p. 559-561 3 p.

Research output: Contribution to journalArticle

Norwood Procedures
Thoracic Aorta
Brachiocephalic Trunk
Sternotomy
Diaphragm
51 Citations (Scopus)

Positive inotropic effect of insulin-like growth factor-1 on normal and failing cardiac myocytes

Kinugawa, S., Tsutsui, H., Ide, T., Nakamura, R., Arimura, K. I., Egashira, K. & Takeshita, A., Jul 1999, In : Cardiovascular research. 43, 1, p. 157-164 8 p.

Research output: Contribution to journalArticle

Somatomedins
Cardiac Myocytes
Growth Hormone
Heart Failure
Muscle Cells
24 Citations (Scopus)

Results of laparoscopic splenectomy for immune thrombocytopenic purpura

Tanoue, K., Hashizume, M., Morita, M., Migoh, S., Tsugawa, K., Yagi, S., Ohta, M. & Sugimachi, K., Mar 1999, In : American Journal of Surgery. 177, 3, p. 222-226 5 p.

Research output: Contribution to journalArticle

Idiopathic Thrombocytopenic Purpura
Splenectomy
Hereditary Spherocytosis
Inborn Genetic Diseases
Operative Time
10 Citations (Scopus)

Role of Ca2+ availability to myofilaments and their sensitivity to Ca2+ in myocyte contractile dysfunction in heart failure

Kinugawa, S., Tsutsui, H., Satoh, S., Takahashi, M., Ide, T., Igarashi-Saito, K., Arimura, K. I., Egashira, K. & Takeshita, A., Nov 1 1999, In : Cardiovascular research. 44, 2, p. 398-406 9 p.

Research output: Contribution to journalArticle

Myofibrils
Muscle Cells
Heart Failure
Sarcomeres
Fluorescence