Department of Advanced Medical Initiatives

Research Output 1980 2019

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2015
28 Citations (Scopus)

Engrafted Neural Stem/Progenitor Cells Promote Functional Recovery through Synapse Reorganization with Spared Host Neurons after Spinal Cord Injury

Yokota, K., Kobayakawa, K., Kubota, K., Miyawaki, A., Okano, H., Ohkawa, Y., Iwamoto, Y. & Okada, S., Jan 1 2015, In : Stem Cell Reports. 5, 2, p. 264-277 14 p.

Research output: Contribution to journalArticle

Neural Stem Cells
Stem cells
Spinal Cord Injuries
Synapses
Neurons
6 Citations (Scopus)

Epigenome-wide association study suggests that SNPs in the promoter region of RETN influence plasma resistin level via effects on DNA methylation at neighbouring sites

Nakatochi, M., Ichihara, S., Yamamoto, K., Ohnaka, K., Kato, Y., Yokota, S., Hirashiki, A., Naruse, K., Asano, H., Izawa, H., Matsubara, T. & Yokota, M., Sep 24 2015, In : Diabetologia. 58, 12, p. 2781-2790 10 p.

Research output: Contribution to journalArticle

Resistin
DNA Methylation
Genetic Promoter Regions
Single Nucleotide Polymorphism
Genes
5 Citations (Scopus)

Establishment of a two-dimensional chiral HPLC system for the simultaneous detection of lactate and 3-hydroxybutyrate enantiomers in human clinical samples

Liu, S. L., Oyama, T., Miyoshi, Y., Sheu, S. Y., Mita, M., Ide, T., Lindner, W., Hamase, K. & Lee, J. A., Dec 10 2015, In : Journal of Pharmaceutical and Biomedical Analysis. 116, p. 80-85 6 p.

Research output: Contribution to journalArticle

3-Hydroxybutyric Acid
Enantiomers
Lactic Acid
High Pressure Liquid Chromatography
formic acid
23 Citations (Scopus)

European Heart Rhythm Association/Heart Failure Association joint consensus document on arrhythmias in heart failure, endorsed by the Heart Rhythm Society and the Asia Pacific Heart Rhythm Society

Lip, G. Y. H., Heinzel, F. R., Gaita, F., Juanatey, J. R. G., Le Heuzey, J. Y., Potpara, T., Svendsen, J. H., Vos, M. A., Anker, S. D., Coats, A. J., Haverkamp, W., Manolis, A. S., Chung, M. K., Sanders, P., Pieske, B., Gorenek, B., Lane, D., Boriani, G., Linde, C., Hindricks, G. & 9 others, Tsutsui, H., Homma, S., Brownstein, S., Nielsen, J. C., Lainscak, M., Crespo-Leiro, M., Piepoli, M., Seferovic, P. & Savelieva, I., Dec 28 2015, In : Europace. 18, 1, p. 12-36 25 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Evaluation of techniques to prevent colorectal anastomotic leakage

Ikeda, T., Kumashiro, R., Oki, E., Taketani, K., Andou, K., Aishima, S., Akahoshi, T., Morita, M. & Maehara, Y., Apr 1 2015, In : Journal of Surgical Research. 194, 2, p. 450-457 8 p.

Research output: Contribution to journalArticle

Anastomotic Leak
Hand
Pressure
Polyesters
Rectal Neoplasms
5 Citations (Scopus)

Expression and characterization of myristoylated preS1-conjugated nanocages for targeted cell delivery

Murata, M., Piao, J. S., Narahara, S., Kawano, T., Hamano, N., Kang, J. H., Asai, D., Ugawa, R. & Hashizume, M., Jan 1 2015, In : Protein Expression and Purification. 110, p. 52-56 5 p.

Research output: Contribution to journalArticle

Ferritins
Hepatocytes
Lipids
Peptides
Genetic Engineering
20 Citations (Scopus)

Favipiravir: A New Medication for the Ebola Virus Disease Pandemic

Nagata, T., Lefor, A. K., Hasegawa, M. & Ishii, M., Oct 7 2015, In : Disaster Medicine and Public Health Preparedness. 9, 1, p. 79-81 3 p.

Research output: Contribution to journalArticle

Ebola Hemorrhagic Fever
Pandemics
Ebolavirus
Japan
Lassa Fever
7 Citations (Scopus)

Gastric endoscopic submucosal dissection using novel 26-mm articulating devices: an ex vivo comparative and in vivo feasibility study

Nakadate, R., Nakamura, S., Tomohiko, M., Kenmotsu, H., Oguri, S., Arata, J., Uemura, M., Ouchida, K., Akahoshi, T., Ikeda, T. & Hashizume, M., Sep 1 2015, In : Endoscopy. 47, 9, p. 820-824 5 p.

Research output: Contribution to journalArticle

Feasibility Studies
Stomach
Equipment and Supplies
Dissection
Endoscopes

Gastroenterological Surgery: Pancreas

Tanaka, M., Tomikawa, M., Nakamura, M., Nakamura, Y., Misawa, T., Akahoshi, T., Kinjyo, N., Sumiyoshi, H., Tsutsumi, K., Tsutsumi, N., Nakashima, H., Higashida, M., Fujiwara, Y., Matsushita, A. & Matsumoto, M., Aug 1 2015, In : Asian journal of endoscopic surgery. 8, 3, p. 239-242 4 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Laparoscopic Splenectomy with Technical Standardization and Selection Criteria for Standard or Hand-Assisted Approach in 390 Patients with Liver Cirrhosis and Portal Hypertension

Kawanaka, H., Akahoshi, T., Kinjo, N., Harimoto, N., itoh, S., Tsutsumi, N., Matsumoto, Y., Yoshizumi, T., Shirabe, K. & Maehara, Y., Jan 1 2015, In : Journal of the American College of Surgeons. 221, 2, p. 354-366 13 p.

Research output: Contribution to journalArticle

Portal Hypertension
Splenectomy
Liver Cirrhosis
Patient Selection
Hand
1 Citation (Scopus)

Long-term comparison of three types of aortic St. Jude medical mechanical prosthesis in Japanese patients

Nishida, T., Sonoda, H., Oishi, Y., Tanoue, Y., Tatewaki, H., Shiokawa, Y. & Tominaga, R., Sep 25 2015, In : Circulation Journal. 79, 10, p. 2193-2200 8 p.

Research output: Contribution to journalArticle

Prostheses and Implants
Aortic Valve
Age Groups
Hospital Mortality
Cause of Death
3 Citations (Scopus)

Mapping the genetic diversity of HLA haplotypes in the Japanese populations

Japanese Genome Variation Consortium, Dec 9 2015, In : Scientific reports. 5, 17855.

Research output: Contribution to journalArticle

Haplotypes
Japan
Major Histocompatibility Complex
Population
Human Genome
6 Citations (Scopus)

Mediastinal paraganglioma

Takashima, Y., Kamitani, T., Kawanami, S., Nagao, M., Yonezawa, M., Yamasaki, Y., Baba, S., Yabuuchi, H., Hida, T., Kouhashi, K., Nakamura, K., Sonoda, H., Oda, Y. & Honda, H., Jul 25 2015, In : Japanese Journal of Radiology. 33, 7, p. 433-436 4 p.

Research output: Contribution to journalArticle

Paraganglioma
3-Iodobenzylguanidine
Neoplasms
Fluorodeoxyglucose F18
Radionuclide Imaging
16 Citations (Scopus)

Mitochondrial transcription factor a regulation of mitochondrial degeneration in experimental diabetic neuropathy

Chandrasekaran, K., Anjaneyulu, M., Inoue, T., Choi, J., Sagi, A. R., Chen, C., Ide, T. & Russell, J. W., Jul 15 2015, In : American Journal of Physiology - Endocrinology and Metabolism. 309, 2, p. E132-E141

Research output: Contribution to journalArticle

Diabetic Neuropathies
Transcription Factors
Mitochondrial DNA
Transgenic Mice
Neural Conduction
16 Citations (Scopus)

Myocardial shortening in 3 orthogonal directions and its transmural variation in patients with nonobstructive hypertrophic cardiomyopathy

Okada, K., Yamada, S., Iwano, H., Nishino, H., Nakabachi, M., Yokoyama, S., Abe, A., Ichikawa, A., Kaga, S., Nishida, M., Hayashi, T., Murai, D., Mikami, T. & Tsutsui, H., Oct 23 2015, In : Circulation Journal. 79, 11, p. 2471-2479 9 p.

Research output: Contribution to journalArticle

Hypertrophic Cardiomyopathy
Stroke Volume
Echocardiography
Maintenance
Direction compound
2 Citations (Scopus)

New approach to complete video-assisted thoracoscopic lobectomy in T2 and T3 non-small cell lung cancer

Kato, M., Ohnishi, H., Furugaki, K., Yunotani, S., Matsumoto, K., Tsuruta, N., Nakamura, K. & Katano, M., Jan 1 2015, In : Anticancer research. 35, 6, p. 3585-3589 5 p.

Research output: Contribution to journalArticle

Video-Assisted Thoracic Surgery
Non-Small Cell Lung Carcinoma
Lung Neoplasms
Ribs
Thorax
2 Citations (Scopus)

Novel, high-definition 3-D endoscopy system with real-time compression communication system to aid diagnoses and treatment between hospitals in Thailand

Uemura, M., Kenmotsu, H., Tomikawa, M., Kumashiro, R., Yamashita, M., Ikeda, T., Yamashita, H., Chiba, T., Hayashi, K., Sakae, E., Eguchi, M., Fukuyo, T., Chittmittrapap, S., Navicharern, P., Chotiwan, P., Pattana-Arum, J. & Hashizume, M., May 1 2015, In : Asian journal of endoscopic surgery. 8, 2, p. 139-147 9 p.

Research output: Contribution to journalArticle

Computer Systems
Thailand
Laparoscopy
Endoscopy
Needles

Novel Surgical Skill Evaluation with Reference to Two-handed Coordination

Uemura, M., Sakata, K., Tomikawa, M., Nagao, Y., Ouchida, K., Ieiri, S., Akahoshi, T. & Hashizume, M., Jul 1 2015, In : Fukuoka igaku zasshi = Hukuoka acta medica. 106, 7, p. 213-222 10 p.

Research output: Contribution to journalArticle

Laparoscopy
Minimally Invasive Surgical Procedures
Medical Students
Surgeons
14 Citations (Scopus)

Objective assessment of the suture ligature method for the laparoscopic intestinal anastomosis model using a new computerized system

Uemura, M., Yamashita, M., Tomikawa, M., Obata, S., Souzaki, R., Ieiri, S., Ohuchida, K., Matsuoka, N., Katayama, T. & Hashizume, M., Feb 1 2015, In : Surgical Endoscopy. 29, 2, p. 444-452 9 p.

Research output: Contribution to journalArticle

Sutures
Ligation
Air Pressure
Laparoscopy
Wounds and Injuries
49 Citations (Scopus)

Overexpression of TFAM or twinkle increases mtDNA copy number and facilitates cardioprotection associated with limited mitochondrial oxidative stress

Ikeda, M., Ide, T., Fujino, T., Arai, S., Saku, K., Kakino, T., Tyynismaa, H., Yamasaki, T., Yamada, K. I., Kang, D., Suomalainen, A. & Sunagawa, K., Mar 30 2015, In : PloS one. 10, 3, e0119687.

Research output: Contribution to journalArticle

Mitochondria
Oxidative stress
Mitochondrial DNA
reactive oxygen species
Reactive Oxygen Species

Pharmacotherapy of hypertrophic cardiomyopathy

Tsutsui, H., Jul 1 2015, In : Respiration and Circulation. 63, 7, p. 623-629 7 p.

Research output: Contribution to journalArticle

Hypertrophic Cardiomyopathy
Drug Therapy
6 Citations (Scopus)

Pneumoperitoneum simulation based on mass-spring-damper models for laparoscopic surgical planning

Nimura, Y., Di Qu, J., Hayashi, Y., Oda, M., Kitasaka, T., Hashizume, M., Misawa, K. & Mori, K., Oct 1 2015, In : Journal of Medical Imaging. 2, 4, 044004.

Research output: Contribution to journalArticle

Anatomic Models
Pneumoperitoneum
Gases
Pressure
Abdominal Wall
4 Citations (Scopus)

Polymorphisms in CYP19A1, HSD17B1 and HSD17B2 genes and serum sex hormone level among postmenopausal Japanese women

Hosono, S., Ito, H., Oze, I., Higaki, Y., Morita, E., Takashima, N., Suzuki, S., Shimatani, K., Mikami, H., Keizo, O., Ozaki, E., Katsuura-Kamano, S., Kubo, M., Nagata, C., Naito, M., Hamajima, N. & Tanaka, H., Dec 1 2015, In : Maturitas. 82, 4, p. 394-401 8 p.

Research output: Contribution to journalArticle

Gonadal Steroid Hormones
Polymorphism
Genes
Single Nucleotide Polymorphism
Serum
7 Citations (Scopus)

Prediction of adverse cardiac events in dilated cardiomyopathy using cardiac T2* MRI and MIBG scintigraphy

Nagao, M., Baba, S., Yonezawa, M., Yamasaki, Y., Kamitani, T., Isoda, T., Kawanami, S., Maruoka, Y., Kitamura, Y., Abe, K., Higo, T., Sunagawa, K. & Honda, H., Feb 27 2015, In : International Journal of Cardiovascular Imaging. 31, 2, p. 399-407 9 p.

Research output: Contribution to journalArticle

Dilated Cardiomyopathy
Radionuclide Imaging
Iron
Ventricular Septum
ROC Curve
7 Citations (Scopus)

Prediction of the impact of venoarterial extracorporeal membrane oxygenation on hemodynamics

Sakamoto, K., Saku, K., Kishi, T., Kakino, T., Tanaka, A., Sakamoto, T., Ide, T. & Sunagawa, K., Jan 1 2015, In : American Journal of Physiology - Heart and Circulatory Physiology. 308, 8, p. H921-H930

Research output: Contribution to journalArticle

Extracorporeal Membrane Oxygenation
Hemodynamics
Atrial Pressure
Cardiac Output
Right Ventricular Function
5 Citations (Scopus)

Predictors and proarrhythmic consequences of inappropriate implantable cardioverter-defibrillator therapy

Tenma, T., Yokoshiki, H., Mizukami, K., Mitsuyama, H., Watanabe, M., Sasaki, R., Maeno, M., Matsui, Y. & Tsutsui, H., Aug 25 2015, In : Circulation Journal. 79, 9, p. 1920-1927 8 p.

Research output: Contribution to journalArticle

Implantable Defibrillators
Shock
Confidence Intervals
Therapeutics
Diuretics
10 Citations (Scopus)

Preoperative surgical simulation of laparoscopic adrenalectomy for neuroblastoma using a three-dimensional printed model based on preoperative CT images

Sozaki, R., Kinoshita, Y., Ieiri, S., Kawakubo, N., Obata, S., Jimbo, T., Koga, Y., Hashizume, M. & Taguchi, T., Jan 1 2015, In : Journal of Pediatric Surgery. 50, 12, p. 2112-2115 4 p.

Research output: Contribution to journalArticle

Adrenalectomy
Neuroblastoma
Tomography
Surgical Instruments
Anatomy
10 Citations (Scopus)

Proteinuria and reduced estimated glomerular filtration rate are independent risk factors for contrast-induced nephropathy after cardiac catheterization

CINC-J study investigators, Jun 9 2015, In : Circulation Journal. 79, 7, p. 1624-1630 7 p.

Research output: Contribution to journalArticle

Cardiac Catheterization
Glomerular Filtration Rate
Proteinuria
Incidence
Japan
8 Citations (Scopus)

Relation Between Dabigatran Concentration, as Assessed Using the Direct Thrombin Inhibitor Assay, and Activated Clotting Time/Activated Partial Thromboplastin Time in Patients With Atrial Fibrillation

Okubo, K., Kuwahara, T., Takagi, K., Takigawa, M., Nakajima, J., Watari, Y., Nakashima, E., Yamao, K., Fujino, T., Tsutsui, H. & Takahashi, A., Jun 15 2015, In : American Journal of Cardiology. 115, 12, p. 1696-1699 4 p., 21051.

Research output: Contribution to journalArticle

Antithrombins
Partial Thromboplastin Time
Atrial Fibrillation
Verapamil
Dabigatran
7 Citations (Scopus)

Risk factors associated with Stenotrophomonas maltophilia Bacteremia: A matched case-control study

Sumida, K., Jeong, Y., Miyake, N., Akahoshi, T., Yasuda, M., Shimono, N., Shimoda, S., Maehara, Y. & Akashi, K., Jul 24 2015, In : PloS one. 10, 7, e0133731.

Research output: Contribution to journalArticle

Stenotrophomonas maltophilia
bacteremia
case-control studies
Case-Control Studies
risk factors

Role of mitochondria and reactive oxygen species in heart failure

Ide, T., Jul 1 2015, In : Japanese Journal of Clinical Chemistry. 44, 3, p. 191-197 7 p.

Research output: Contribution to journalArticle

Reactive Oxygen Species
Mitochondria
Heart Failure
3 Citations (Scopus)

Safe and rapid contouring of fibro-osseous lesions in the orbital area using navigation with minimally invasive cranial bone registration

Kamizono, K., Yoshida, S., Cho, B., Matsumoto, N., Fukushima, J., Jinnouchi, M., Ouchida, R., Sawatsubashi, M., Hashizume, M. & Komune, S., Jan 1 2015, In : Journal of Laryngology and Otology. 129, S2, p. S62-S68

Research output: Contribution to journalArticle

Prefrontal Cortex
Bone and Bones
Bone Development
Information Systems
Cosmetics
6 Citations (Scopus)

Scoliosis in patients with multiple hereditary exostoses

Matsumoto, Y., Matsumoto, K., Harimaya, K., Okada, S., Doi, T. & Iwamoto, Y., Jul 27 2015, In : European Spine Journal. 24, 7, p. 1568-1573 6 p.

Research output: Contribution to journalArticle

Multiple Hereditary Exostoses
Scoliosis
Inborn Genetic Diseases
Spine
10 Citations (Scopus)

Serum brain-derived neurotropic factor level predicts adverse clinical outcomes in patients with heart failure

Fukushima, A., Kinugawa, S., Homma, T., Masaki, Y., Furihata, T., Yokota, T., Matsushima, S., Takada, S., Kadoguchi, T., Oba, K., Okita, K. & Tsutsui, H., Apr 1 2015, In : Journal of Cardiac Failure. 21, 4, p. 300-306 7 p.

Research output: Contribution to journalArticle

Heart Failure
Brain
Serum
Anaerobic Threshold
Carbon Dioxide
11 Citations (Scopus)

Sesamin prevents decline in exercise capacity and impairment of skeletal muscle mitochondrial function in mice with high-fat diet-induced diabetes

Takada, S., Kinugawa, S., Matsushima, S., Takemoto, D., Furihata, T., Mizushima, W., Fukushima, A., Yokota, T., Ono, Y., Shibata, H., Okita, K. & Tsutsui, H., Nov 1 2015, In : Experimental Physiology. 100, 11, p. 1319-1330 12 p.

Research output: Contribution to journalArticle

High Fat Diet
Skeletal Muscle
NADPH Oxidase
Diet
Superoxides
10 Citations (Scopus)

Small-conductance Ca2+-activated K+ current is upregulated via the phosphorylation of CaMKII in cardiac hypertrophy from spontaneously hypertensive rats

Mizukami, K., Yokoshiki, H., Mitsuyama, H., Watanabe, M., Tenma, T., Takada, S. & Tsutsui, H., Sep 18 2015, In : American Journal of Physiology - Heart and Circulatory Physiology. 309, 6, p. H1066-H1074

Research output: Contribution to journalArticle

Calcium-Calmodulin-Dependent Protein Kinase Type 2
Cardiomegaly
Inbred SHR Rats
Phosphorylation
Apamin
16 Citations (Scopus)

Spatial re-organization of myogenic regulatory sequences temporally controls gene expression

Harada, A., Mallappa, C., Okada, S., Butler, J. T., Baker, S. P., Lawrence, J. B., Ohkawa, Y. & Imbalzano, A. N., Feb 27 2015, In : Nucleic acids research. 43, 4, p. 2008-2021 14 p.

Research output: Contribution to journalArticle

Gene Expression
Genes
Muscle Development
Myogenin
Chromatin Assembly and Disassembly
11 Citations (Scopus)

The Akt-mTOR axis is a pivotal regulator of eccentric hypertrophy during volume overload

Ikeda, M., Ide, T., Fujino, T., Matsuo, Y., Arai, S., Saku, K., Kakino, T., Oga, Y., Nishizaki, A. & Sunagawa, K., Oct 30 2015, In : Scientific reports. 5, 15881.

Research output: Contribution to journalArticle

Sirolimus
Hypertrophy
Blood Pressure
Cardiomegaly
Cardiac Output
1 Citation (Scopus)

The effect of forceps manipulation for expert pediatric surgeons using an endoscopic pseudo-viewpoint alternating system: the phenomenon of economical slow and fast performance in endoscopic surgery

Ieiri, S., Jimbo, T., Koreeda, Y., Obata, S., Uemura, M., Sozaki, R., Kobayashi, Y., Fujie, M. G., Hashizume, M. & Taguchi, T., Oct 22 2015, In : Pediatric surgery international. 31, 10, p. 971-976 6 p.

Research output: Contribution to journalArticle

Surgical Instruments
Pediatrics
Sutures
Fundoplication
Surgeons
10 Citations (Scopus)

The number of prehospital defibrillation shocks and 1-month survival in patients with out-of-hospital cardiac arrest

Hasegawa, M., Abe, T., Nagata, T., Onozuka, D. & Hagihara, A., Apr 17 2015, In : Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine. 23, 1, 34.

Research output: Contribution to journalArticle

Out-of-Hospital Cardiac Arrest
Shock
Survival
Odds Ratio
Defibrillators
32 Citations (Scopus)

Three-dimensional liver model based on preoperative CT images as a tool to assist in surgical planning for hepatoblastoma in a child

Souzaki, R., Kinoshita, Y., Ieiri, S., Hayashida, M., Koga, Y., Shirabe, K., Hara, T., Maehara, Y., Hashizume, M. & Taguchi, T., Apr 23 2015, In : Pediatric surgery international. 31, 6, p. 593-596 4 p.

Research output: Contribution to journalArticle

Hepatoblastoma
Liver
Drug Therapy
Neoplasms
Three Dimensional Printing
140 Citations (Scopus)

Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation

Kato, N., Loh, M., Takeuchi, F., Verweij, N., Wang, X., Zhang, W., NKelly, T., Saleheen, D., Lehne, B., Leach, I. M., Drong, A. W., Abbott, J., Wahl, S., Tan, S. T., Scott, W. R., Campanella, G., Chadeau-Hyam, M., Afzal, U., Ahluwalia, T. S., Bonder, M. J. & 225 others, Chen, P., Dehghan, A., Edwards, T. L., Esko, T., Go, M. J., Harris, S. E., Hartiala, J., Kasela, S., Kasturiratne, A., Khor, C. C., Kleber, M. E., Li, H., Mok, Z. Y., Nakatochi, M., Sapari, N. S., Saxena, R., Stewart, A. F. R., Stolk, L., Tabara, Y., Teh, A. L., Wu, Y., Wu, J. Y., Zhang, Y., Aits, I., Da Silva Couto Alves, A., Das, S., Dorajoo, R., CHopewell, J., Kim, Y. K., WKoivula, R., Luan, JA., Lyytikäinen, L. P., NNguyen, Q., Pereira, M. A., Postmus, I., TRaitakari, O., Scannell Bryan, M., Scott, R. A., Sorice, R., Tragante, V., Traglia, M., White, J., Yamamoto, K., Zhang, Y., Adair, L. S., Ahmed, A., Akiyama, K., Asif, R., Aung, T., Barroso, I., Bjonnes, A., Braun, T. R., Cai, H., Chang, L. C., Chen, C. H., Cheng, C. Y., Chong, Y. S., Collins, R., Courtney, R., Davies, G., Delgado, G., Do, L. D., Doevendans, P. A., Gansevoort, R. T., Gao, Y. T., Grammer, T. B., Grarup, N., Grewal, J., Gu, D., SWander, G., Hartikainen, A. L., Hazen, S. L., He, J., Heng, C. K., Hixso, E. J. A., Hofman, A., Hsu, C., Huang, W., Husemoen, L. L. N., Hwang, J. Y., Ichihara, S., Igase, M., Isono, M., Justesen, J. M., Katsuya, T., GKibriya, M., Kim, Y. J., Kishimoto, M., Koh, W. P., Kohara, K., Kumari, M., Kwek, K., Lee, N. R., Lee, J., Liao, J., Lieb, W., Liewald, D. C. M., Matsubara, T., Matsushita, Y., Meitinger, T., Mihailov, E., Milani, L., Mills, R., Mononen, N., Müller-Nurasyid, M., Nabika, T., Nakashima, E., Ng, H. K., Nikus, K., Nutile, T., Ohkubo, T., Ohnaka, K., Parish, S., Paternoster, L., Peng, H., Peters, A., TPham, S., Pinidiyapathirage, M. J., Rahman, M., Rakugi, H., Rolandsson, O., Rozario, M. A., Ruggiero, D., Sala, C. F., Sarju, R., Shimokawa, K., Snieder, H., SparsØ, T., Spiering, W., Starr, J. M., Stott, D. J., OStram, D., Sugiyama, T., Szymczak, S., Tang, W. H. W., Tong, L., Trompet, S., Turjanmaa, V., Ueshima, H., Uitterlinden, A. G., Umemura, S., Vaarasmaki, M., Dam, R. M., Van Gilst, W. H., Van Veldhuisen, D. J., Viikari, J. S., Waldenberger, M., Wang, Y., Wang, A., Wilson, R., Wong, T. Y., Xiang, Y. B., Yamaguchi, S., Ye, X., Young, R. D., Young, T. L., Yuan, J. M., Zhou, X., Asselbergs, F. W., Ciullo, M., Clarke, R., Deloukas, P., Franke, A., Paul, W. F., Franks, S., Friedlander, Y., Gross, M. D., Guo, Z., Hansen, T., Jarvelin, M. R., JØrgensen, T., Jukema, J. W., Kähönen, M., Kajio, H., Kivimaki, M., Lee, J. Y., Lehtimäki, T., Linneberg, A., Miki, T., Pedersen, O., Samani, N. J., SØrensen, T. I. A., Takayanagi, R., Toniolo, D., Ahsan, H., Allayee, H., Chen, Y. T., Danesh, J., Deary, I. J., Franco, O. H., Franke, L., THeijman, B., Holbrook, J. D., Isaacs, A., Kim, B. J., Lin, X., Liu, J., März, W., Metspalu, A., Mohlke, K. L., Sangher, K., Harambir, D., Shu, X. O., Van Meurs, J. B. J., Vithana, E., Wickremasinghe, A. R., Wijmenga, C., Wolffenbuttel, B. H. W., Yokota, M., Zheng, W., Zhu, D., Vineis, P., Kyrtopoulos, S. A., Kleinjans, J. C. S., McCarthy, M. I., Soong, R., Gieger, C., Scott, J., Teo, Y. Y., He, J., Elliott, P., Tai, E. S., Van Der Harst, P., Kooner, J. S. & Chambers, J. C., Nov 1 2015, In : Nature genetics. 47, 11, p. 1282-1293 12 p.

Research output: Contribution to journalArticle

Genetic Loci
Genome-Wide Association Study
DNA Methylation
Blood Pressure
Single Nucleotide Polymorphism
2 Citations (Scopus)

Treatment results of two-stage operation for the patients with esophageal cancer concomitant with liver dysfunction

Yasuda, M., Saeki, H., Nakashima, Y., Yukaya, T., Tsutsumi, S., Tajiri, H., Zaitsu, Y., Tsuda, Y., Kasagi, Y., Ando, K., Imamura, Y., Ohgaki, K., Akahoshi, T., Oki, E. & Maehara, Y., Sep 18 2015, In : Journal of Medical Investigation. 62, 3, p. 149-153 5 p.

Research output: Contribution to journalArticle

Esophageal Neoplasms
Liver
Liver Diseases
Blood
Therapeutics
1 Citation (Scopus)

Trypsin-induced biphasic regulation of tone in the porcine lower esophageal sphincter

Tanaka, Y., Ihara, E., Hirano, K., Takahashi, S., Hirano, M., Nakamura, K., Akiho, H., Oda, Y. & Takayanagi, R., Apr 5 2015, In : European Journal of Pharmacology. 752, p. 97-105 9 p.

Research output: Contribution to journalArticle

Lower Esophageal Sphincter
Trypsin
Swine
rho-Associated Kinases
Protein Kinases
2014
21 Citations (Scopus)

Acute hyperglycemia impairs functional improvement after spinal cord injury in mice and humans

Kobayakawa, K., Kumamaru, H., Saiwai, H., Kubota, K., Ohkawa, Y., Kishimoto, J., Yokota, K., Ideta, R., Shiba, K., Tozaki-Saitoh, H., Inoue, K., Iwamoto, Y. & Okada, S., Oct 1 2014, In : Science Translational Medicine. 6, 256, 256ra137.

Research output: Contribution to journalArticle

Spinal Cord Injuries
Hyperglycemia
Obese Mice
Nervous System Trauma
Blood Glucose
29 Citations (Scopus)

Afferent vagal nerve stimulation resets baroreflex neural arc and inhibits sympathetic nerve activity

Saku, K., Kishi, T., Sakamoto, K., Hosokawa, K., Sakamoto, T., Murayama, Y., Kakino, T., Ikeda, M., Ide, T. & Sunagawa, K., Jan 1 2014, In : Physiological Reports. 2, 9, e12136.

Research output: Contribution to journalArticle

Vagus Nerve Stimulation
Baroreflex
Arterial Pressure
Splanchnic Nerves
Carotid Sinus
32 Citations (Scopus)

Analysis of hand motion differentiates expert and novice surgeons

Uemura, M., Tomikawa, M., Kumashiro, R., Miao, T., Sozaki, R., Ieiri, S., Ouchida, K., Lefor, A. T. & Hashizume, M., May 1 2014, In : Journal of Surgical Research. 188, 1, p. 8-13 6 p.

Research output: Contribution to journalArticle

Hand
Orbit
Gravitation
Needles
Surgeons
4 Citations (Scopus)

An epithelial cell adhesion molecule- and CD3-bispecific antibody plus activated T-cells can eradicate chemoresistant cancer stem-like pancreatic carcinoma cells in vitro

Umebayashi, M., Kiyota, A., Koya, N., Tanaka, H., Ohnishi, H., Katano, M. & Morisaki, T., Aug 1 2014, In : Anticancer research. 34, 8, p. 4509-4520 12 p.

Research output: Contribution to journalArticle

Bispecific Antibodies
Neoplastic Stem Cells
T-Lymphocytes
Pancreatic Neoplasms
Neoplasms
7 Citations (Scopus)

A polymorphism near MC4R gene (rs17782313) is associated with serum triglyceride levels in the general Japanese population: The J-MICC Study

Katsuura-Kamano, S., Uemura, H., Arisawa, K., Yamaguchi, M., Hamajima, N., Wakai, K., Okada, R., Suzuki, S., Taguchi, N., Kita, Y., Keizo, O., Kairupan, T. S., Matsui, D., Oze, I., Mikami, H., Kubo, M. & Tanaka, H., Jan 1 2014, In : Endocrine. 47, 1, p. 81-89 9 p.

Research output: Contribution to journalArticle

Receptor, Melanocortin, Type 4
Japan
Triglycerides
Cohort Studies
Body Mass Index
10 Citations (Scopus)

A preregistered STAMP method for image-guided temporal bone surgery

Oka, M., Cho, B., Matsumoto, N., Hong, J., Jinnouchi, M., Ouchida, R., Komune, S. & Hashizume, M., Jan 1 2014, In : International journal of computer assisted radiology and surgery. 9, 1, p. 119-126 8 p.

Research output: Contribution to journalArticle

Temporal Bone
Operating rooms
Surgery
Bone
Operating Rooms