Department of Advanced Medical Initiatives

Research Output 1980 2019

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Review article
2019

Inconsistency in the standard of care-toward evidence-based management of exertional heat stroke

Hosokawa, Y., Nagata, T. & Hasegawa, M., Jan 1 2019, In : Frontiers in Physiology. 10, FEB, 108.

Research output: Contribution to journalReview article

Open Access
Heat Stroke
Standard of Care
Extreme Heat
Tokyo
Hot Temperature

Ivabradine for the treatment of cardiovascular diseases

Ide, T., Ohtani, K., Higo, T., Tanaka, M., Kawasaki, Y. & Tsutsui, H., Feb 1 2019, In : Circulation Journal. 83, 2, p. 252-260 9 p.

Research output: Contribution to journalReview article

ivabradine
Cardiovascular Diseases
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels
Sinoatrial Node
Heart Failure
2018
22 Citations (Scopus)

Astrocyte reactivity and astrogliosis after spinal cord injury

Okada, S., Hara, M., Kobayakawa, K., Matsumoto, Y. & Nakashima, Y., Jan 1 2018, In : Neuroscience Research. 126, p. 39-43 5 p.

Research output: Contribution to journalReview article

Spinal Cord Injuries
Astrocytes
Cicatrix
Neuroglia
Central Nervous System
2 Citations (Scopus)

Pulmonary valve replacement after repaired Tetralogy of Fallot

Tatewaki, H. & Shiose, A., Sep 1 2018, In : General thoracic and cardiovascular surgery. 66, 9, p. 509-515 7 p.

Research output: Contribution to journalReview article

Pulmonary Valve
Tetralogy of Fallot
Pulmonary Valve Insufficiency
Sudden Death
Cardiac Arrhythmias
2017
1 Citation (Scopus)

Factors associated with the occurrence of injuries requiring hospital transfer among older and working-age pedestrians in Kurume, Japan

Nagata, T., Abe, T., Takamori, A., Kimura, Y. & Hagihara, A., Jun 2 2017, In : BMC Public Health. 17, 1, 537.

Research output: Contribution to journalReview article

Japan
Wounds and Injuries
Social Class
Pedestrians
Geographic Information Systems

Management of Right Heart Failure after Cardiac Surgery

Fujino, T. & Shiose, A., Jul 1 2017, In : Kyobu geka. The Japanese journal of thoracic surgery. 70, 8, p. 617-621 5 p.

Research output: Contribution to journalReview article

Thoracic Surgery
Heart Failure
Heart-Assist Devices
Perioperative Period
Heart Ventricles
9 Citations (Scopus)

Nanoparticle-mediated drug delivery system for atherosclerotic cardiovascular disease

Matoba, T., Koga, J. I., Nakano, K., Egashira, K. & Tsutsui, H., Sep 1 2017, In : Journal of Cardiology. 70, 3, p. 206-211 6 p.

Research output: Contribution to journalReview article

Drug Delivery Systems
Nanoparticles
Cardiovascular Diseases
pioglitazone
Monocytes
55 Citations (Scopus)

The potential role and rationale for treatment of heart failure with sodium–glucose co-transporter 2 inhibitors

on behalf of the EMPEROR Trials Program, Nov 1 2017, In : European Journal of Heart Failure. 19, 11, p. 1390-1400 11 p.

Research output: Contribution to journalReview article

Symporters
Treatment Failure
Heart Failure
Type 2 Diabetes Mellitus
Medical Economics
2016
2 Citations (Scopus)

Dehydroepiandrosterone(DHEA)and bone metabolism

Keizo, O., Jul 1 2016, In : Clinical calcium. 26, 7, p. 987-993 7 p.

Research output: Contribution to journalReview article

Dehydroepiandrosterone
Bone and Bones
Androgens
Osteoporosis
Aromatase
Natural Killer T-Cells
Galactosylceramides
Heart Failure
Myocardial Infarction
Ventricular Remodeling
Heart-Assist Devices
Heart Transplantation
Japan
Heart Failure
Skeletal Myoblasts
2015
4 Citations (Scopus)

Next-generation robotic surgery - From the aspect of surgical robots developed by industry

Nakadate, R., Arata, J. & Hashizume, M., Jan 1 2015, In : Minimally Invasive Therapy and Allied Technologies. 24, 1, p. 2-7 6 p.

Research output: Contribution to journalReview article

Robotics
Industry
Aptitude
Research
Surgical Instruments
32 Citations (Scopus)

Skeletal muscle abnormalities in heart failure

Kinugawa, S., Takada, S., Matsushima, S., Okita, K. & Tsutsui, H., Sep 29 2015, In : International heart journal. 56, 5, p. 475-484 10 p.

Research output: Contribution to journalReview article

Skeletal Muscle
Heart Failure
Muscular Atrophy
Exercise
Muscle Strength
2014
40 Citations (Scopus)

Physiological and pathological functions of NADPH oxidases during myocardial ischemia-reperfusion

Matsushima, S., Tsutsui, H. & Sadoshima, J., Jan 1 2014, In : Trends in Cardiovascular Medicine. 24, 5, p. 202-205 4 p.

Research output: Contribution to journalReview article

Myocardial Reperfusion
NADPH Oxidase
Myocardial Ischemia
Reactive Oxygen Species
Reperfusion Injury
2013
20 Citations (Scopus)

Biological evaluation of protein nanocapsules containing doxorubicin

Riki, T., Murata, M., Abe, K., Narahara, S., Piao, J. S., Kang, J. H., Ouchida, K. & Hashizume, M., May 16 2013, In : International journal of nanomedicine. 8, p. 1989-1999 11 p.

Research output: Contribution to journalReview article

Nanocapsules
Doxorubicin
Proteins
Mitochondria
Fluorophores
55 Citations (Scopus)

Exercise intolerance in chronic heart failure - Skeletal muscle dysfunction and potential therapies

Okita, K., Kinugawa, S. & Tsutsui, H., Feb 4 2013, In : Circulation Journal. 77, 2, p. 293-300 8 p.

Research output: Contribution to journalReview article

Skeletal Muscle
Heart Failure
Exercise
Exercise Tolerance
Anaerobiosis
14 Citations (Scopus)

Robotic surgery for cancer

Ouchida, K. & Hashizume, M., Mar 1 2013, In : Cancer Journal (United States). 19, 2, p. 130-132 3 p.

Research output: Contribution to journalReview article

Robotics
Neoplasms
Minimally Invasive Surgical Procedures
Therapeutics
Technology
2012
31 Citations (Scopus)

Cancer immunotherapy using NKG2D and DNAM-1 systems

Morisaki, T., Ohnishi, H. & Katano, M., Jun 2012, In : Anticancer Research. 32, 6, p. 2241-2247 7 p.

Research output: Contribution to journalReview article

Immunotherapy
Neoplasm Antigens
Neoplasms
T-Cell Antigen Receptor
Ligands
12 Citations (Scopus)

Immunotherapy approaches targeting regulatory T-cells

Ohnishi, H., Morisaki, T. & Katano, M., Mar 2012, In : Anticancer Research. 32, 3, p. 997-1003 7 p.

Research output: Contribution to journalReview article

Regulatory T-Lymphocytes
Immunotherapy
Immune System
Neoplasms

Robotic surgery for cancer treatment

Oouchida, K., Ieiri, S., Kenmotsu, H., Tomikawa, M. & Hashizume, M., Jan 15 2012, In : Japanese Journal of Cancer and Chemotherapy. 39, 1, p. 1-7 7 p.

Research output: Contribution to journalReview article

Robotics
Minimally Invasive Surgical Procedures
Neoplasms
Microsurgery
Surgical Instruments
2011

[Molecular mechanisms underlying the increased contractility of smooth muscle in cerebral artery after subarachnoid hemmorhage].

Kikkawa, Y., Sasaki, T., Hirano, M. & Hirano, K., Dec 1 2011, In : Fukuoka igaku zasshi = Hukuoka acta medica. 102, 12, p. 325-332 8 p.

Research output: Contribution to journalReview article

Calcium-Sensing Receptors
Cerebral Arteries
Subarachnoid Hemorrhage
Muscle Contraction
Vasoconstriction
3 Citations (Scopus)

Advantages of the L-incision approach comprising a combination of left anterior thoracotomy and upper half-median sternotomy for aortic arch aneurysms

Oishi, Y., Sonoda, H., Tanoue, Y., Nishida, T., Tokunaga, S., Nakashima, A., Shiokawa, Y. & Tominaga, R., Sep 1 2011, In : Interactive Cardiovascular and Thoracic Surgery. 13, 3, p. 280-283 4 p.

Research output: Contribution to journalReview article

Sternotomy
Aortic Aneurysm
Thoracotomy
Thoracic Aorta
Aneurysm
34 Citations (Scopus)

Clinical and experimental evidence for oxidative stress as an exacerbating factor of diabetes mellitus

Takayanagi, R., Inoguchi, T. & Keizo, O., Jan 1 2011, In : Journal of Clinical Biochemistry and Nutrition. 48, 1, p. 72-77 6 p.

Research output: Contribution to journalReview article

Gilbert Disease
Oxidative stress
Medical problems
Bilirubin
Diabetes Mellitus
67 Citations (Scopus)

Hedgehog signaling pathway as a therapeutic target in various types of cancer

Ohnishi, H. & Katano, M., Oct 1 2011, In : Cancer Science. 102, 10, p. 1756-1760 5 p.

Research output: Contribution to journalReview article

Neoplasms
Medulloblastoma
Rhabdomyosarcoma
Basal Cell Carcinoma
Therapeutics
22 Citations (Scopus)

Management of gastric varices

Hashizume, M., Akahoshi, T. & Tomikawa, M., Jan 1 2011, In : Journal of Gastroenterology and Hepatology (Australia). 26, SUPPL. 1, p. 102-108 7 p.

Research output: Contribution to journalReview article

Esophageal and Gastric Varices
Hemorrhage
Mortality
Incidence
Therapeutics
10 Citations (Scopus)

Oxidative stress in cardiac and skeletal muscle dysfunction associated with diabetes mellitus

Tsutsui, H., Kinugawa, S., Matsushima, S. & Yokota, T., Jan 1 2011, In : Journal of Clinical Biochemistry and Nutrition. 48, 1, p. 68-71 4 p.

Research output: Contribution to journalReview article

Oxidative stress
Medical problems
Muscle
Myocardium
Diabetes Mellitus
2010
1 Citation (Scopus)

[New immunotherapy against cancer: a therapy to control regulatory T cell].

Ohnishi, H., Suzuki, H., Chikazawa, N., Morisaki, T. & Katano, M., Oct 1 2010, In : Fukuoka igaku zasshi = Hukuoka acta medica. 101, 10, p. 207-214 8 p.

Research output: Contribution to journalReview article

Regulatory T-Lymphocytes
Immunotherapy
Neoplasms
Therapeutics
15 Citations (Scopus)

Bilirubin, cardiovascular diseases and cancer: Epidemiological perspectives

Keizo, O. & Kono, S., Jan 1 2010, In : Expert Review of Endocrinology and Metabolism. 5, 6, p. 891-904 14 p.

Research output: Contribution to journalReview article

Bilirubin
Cardiovascular Diseases
Neoplasms
Coronary Disease
Heart Neoplasms
18 Citations (Scopus)

Current status and prerequisites for natural orifice translumenal endoscopic surgery (NOTES).

Tomikawa, M., Xu, H. & Hashizume, M., Jan 1 2010, In : Surgery today. 40, 10, p. 909-916 8 p.

Research output: Contribution to journalReview article

Natural Orifice Endoscopic Surgery
Robotics
Technology
Equipment and Supplies
Minimally Invasive Surgical Procedures
138 Citations (Scopus)

General rules for recording endoscopic findings of esophagogastric varices (2ND EDITION)

Tajiri, T., Yoshida, H., Obara, K., Onji, M., Kage, M., Kitano, S., Kokudo, N., Kokubu, S., Sakaida, I., Sata, M., Tajiri, H., Tsukada, K., Nonami, T., Hashizume, M., Hirota, S., Murashima, N., Moriyasu, F., Saigenji, K., Makuuchi, H., Oho, K. & 6 othersYoshida, T., Suzuki, H., Hasumi, A., Okita, K., Futagawa, S. & Idezuki, Y., Jan 1 2010, In : Digestive Endoscopy. 22, 1, p. 1-9 9 p.

Research output: Contribution to journalReview article

Endosonography
Esophageal and Gastric Varices
Varicose Veins
Portal Hypertension
Blood Vessels

Molecular targeted drugs and immunity

Morisaki, T., Ohnishi, H., Suzuki, H. & Katano, M., Jul 2010, In : Biotherapy. 24, 4, p. 291-295 5 p.

Research output: Contribution to journalReview article

Immunity
Pharmaceutical Preparations
Molecular Targeted Therapy
Neoplasms
Regulatory T-Lymphocytes
2009

Biochemical markers of bone turnover. New aspect. Effects of androgen and estrogen on biochemical markers of bone turnover

Keizo, O. & Takayanagi, R., Jan 1 2009, In : Clinical calcium. 19, 8, p. 1118-1124 7 p.

Research output: Contribution to journalReview article

Bone Remodeling
Androgens
Estrogens
Biomarkers
Selective Estrogen Receptor Modulators

Current state and future perspective of cancer therapy practiced from translational research: Immunotherapy and gene therapy

Katano, M., Ohnishi, H. & Morisaki, T., Sep 2009, In : Biotherapy. 23, 5, p. 347-358 12 p.

Research output: Contribution to journalReview article

Translational Medical Research
Genetic Therapy
Immunotherapy
Neoplasm Genes
Neoplasms
5 Citations (Scopus)

Future prospects in natural orifice translumenal endoscopic surgery (NOTES)

Xu, H., Tomikawa, M., Konishi, K., Ieiri, S., Tanoue, K. & Hashizume, M., Jan 1 2009, In : Fukuoka igaku zasshi = Hukuoka acta medica. 100, 2, p. 43-50 8 p.

Research output: Contribution to journalReview article

Natural Orifice Endoscopic Surgery
Endoscopes
Vagina
Rectum
Esophagus
227 Citations (Scopus)

Mitochondrial oxidative stress and dysfunction in myocardial remodelling

Tsutsui, H., Kinugawa, S. & Matsushima, S., Feb 1 2009, In : Cardiovascular research. 81, 3, p. 449-456 8 p.

Research output: Contribution to journalReview article

Mitochondrial DNA
Reactive Oxygen Species
Oxidative Stress
Peroxiredoxin III
DNA Damage

Tumor immunity and regulatory T cells: Clinical viewpoint

Katano, M., Wada, J., Suzuki, H., Yamasaki, A., Ohnishi, H. & Morisaki, T., May 1 2009, In : Biotherapy. 23, 3, p. 245-255 11 p.

Research output: Contribution to journalReview article

Regulatory T-Lymphocytes
Immunity
Research
Immunotherapy
Neoplasms
2008

Microtechnologies in advanced medicine

Murata, M. & Hashizume, M., Dec 1 2008, In : IEEJ Transactions on Sensors and Micromachines. 128, 10, p. 369-372 4 p.

Research output: Contribution to journalReview article

Medicine
79 Citations (Scopus)

Oxidative stress and mitochondrial DNA damage in heart failure

Tsutsui, H., Kinugawa, S. & Matsushima, S., Oct 6 2008, In : Circulation Journal. 72, SUPPL. A

Research output: Contribution to journalReview article

Mitochondrial DNA
DNA Damage
Reactive Oxygen Species
Oxidative Stress
Heart Failure
2007
1 Citation (Scopus)

Advanced medicine and innovative technology

Tanoue, K. & Hashizume, M., Jan 1 2007, In : Fukuoka igaku zasshi = Hukuoka acta medica. 98, 4, p. 100-105 6 p.

Research output: Contribution to journalReview article

Nanotechnology
Minimally Invasive Surgical Procedures
Robotics
Medicine
Technology
1 Citation (Scopus)

Hormone replacement Up-to-date. Adrenopause and DHEA replacement therapy

Keizo, O. & Takayanagi, R., Jan 1 2007, In : Clinical calcium. 17, 9, p. 1334-1340 7 p.

Research output: Contribution to journalReview article

Dehydroepiandrosterone
Hormones
Therapeutics
Dehydroepiandrosterone Sulfate
Menopause

Long-term results of the Ross procedure

Shiose, A. & Kado, H., Jan 1 2007, In : Nippon Geka Gakkai zasshi. 108, 2, p. 80-84 5 p.

Research output: Contribution to journalReview article

Autografts
Lung
Allografts
Hemolysis
Aortic Valve
15 Citations (Scopus)

MRI-guided laparoscopic and robotic surgery for malignancies

Hashizume, M., Apr 1 2007, In : International Journal of Clinical Oncology. 12, 2, p. 94-98 5 p.

Research output: Contribution to journalReview article

Robotics
Laparoscopy
Magnetic Resonance Imaging
Computer-Assisted Surgery
Neoplasms
20 Citations (Scopus)

Nanotechnology and Its Relevance to the Urologist

Gommersall, L., Shergill, I. S., Ahmed, H. U., Hayne, D., Arya, M., Patel, H. R. H., Hashizume, M. & Gill, I. S., Aug 1 2007, In : European Urology. 52, 2, p. 368-375 8 p.

Research output: Contribution to journalReview article

Nanotechnology
Nanomedicine
Urology
Nanopores
Nanowires
2006

Acute adrenocortical insufficiency

Keizo, O. & Takayanagi, R., Jan 1 2006, In : Nippon rinsho. Japanese journal of clinical medicine. Suppl 1, p. 559-561 3 p.

Research output: Contribution to journalReview article

Physiological Feedback
Adrenal Insufficiency
Acute Disease
Glucocorticoids
Hydrocortisone

Chronic adrenocortical insufficiency(primary, secondary)

Keizo, O. & Takayanagi, R., Jan 1 2006, In : Nippon rinsho. Japanese journal of clinical medicine. Suppl 1, p. 549-552 4 p.

Research output: Contribution to journalReview article

Addison Disease
Hypopituitarism
Aldosterone
Adrenocorticotropic Hormone
Autoimmune Diseases

Glucocorticoid-induced osteoporosis

Keizo, O. & Takayanagi, R., Jan 1 2006, In : Nippon rinsho. Japanese journal of clinical medicine. Suppl 2, p. 87-91 5 p.

Research output: Contribution to journalReview article

Chemical Depression
Bone Density Conservation Agents
Diphosphonates
Osteoblasts
Cell Division
5 Citations (Scopus)

Wnt signaling and glucocorticoid-induced osteoporosis

Keizo, O., Jan 1 2006, In : Clinical calcium. 16, 11, p. 1812-1816 5 p.

Research output: Contribution to journalReview article

Wnt Signaling Pathway
Glucocorticoids
Osteoporosis
Wnt Receptors
Low Density Lipoprotein Receptor-Related Protein-1
2005
2 Citations (Scopus)

Change of endothelial function with aging

Keizo, O. & Takayanagi, R., Jan 1 2005, In : Nippon rinsho. Japanese journal of clinical medicine. 63, 6, p. 989-993 5 p.

Research output: Contribution to journalReview article

Plethysmography
Vascular Endothelium
Blood Vessels
Dilatation
Atherosclerosis

Development of BMP-related drugs

Kawate, H., Keizo, O. & Takayanagi, R., Jan 1 2005, In : Nippon rinsho. Japanese journal of clinical medicine. 63 Suppl 10, p. 463-466 4 p.

Research output: Contribution to journalReview article

Developmental Gene Expression Regulation
Intracellular Signaling Peptides and Proteins
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Oligopeptides
rho GTP-Binding Proteins
1 Citation (Scopus)

Polycystic ovary syndrome

Keizo, O. & Takayanagi, R., Jan 1 2005, In : Nippon rinsho. Japanese journal of clinical medicine. 63, 4, p. 681-686 6 p.

Research output: Contribution to journalReview article

Polycystic Ovary Syndrome
Hyperandrogenism
Insulin Resistance
Insulin
Thiazolidinediones