Research Output 1984 2019

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Article
Article
Temperance
Smoking Cessation
Sleep
Chronic Disease
Heart Failure
Balloon Angioplasty
Pulmonary Hypertension
Lung
Single Photon Emission Computed Tomography Computed Tomography
64 Citations (Scopus)

8-Oxo-dGTPase, which prevents oxidative stress-induced DNA damage, increases in the mitochondria from failing hearts

Tsutsui, H., Ide, T., Shiomi, T., Kang, D., Hayashidani, S., Suematsu, N., Wen, J., Utsumi, H., Hamasaki, N. & Takeshita, A., Dec 11 2001, In : Circulation. 104, 24, p. 2883-2885 3 p.

Research output: Contribution to journalArticle

Heart Mitochondria
DNA Damage
Oxidative Stress
Myocardial Infarction
Reactive Oxygen Species
6 Citations (Scopus)

Abnormalities of cardiac sympathetic neuronal and left ventricular function in chronic mitral regurgitation: Assessment by iodine-123 metaiodobenzylguanidine scintigraphy

Tsutsui, H., Ando -i., S., Kubota, T., Kuroiwa-Matsumoto, M., Egashira, K., Sasaki, M., Kuwabara, Y., Koyanagi, S., Yasui, H. & Takeshita, A., Feb 29 1996, In : American Journal of Cardiac Imaging. 10, 1, p. 14-22 9 p.

Research output: Contribution to journalArticle

3-Iodobenzylguanidine
Mitral Valve Insufficiency
Left Ventricular Function
Radionuclide Imaging
Iodine
3 Citations (Scopus)

Accelerated 99mTc-sestamibi clearance associated with mitochondrial dysfunction and regional left ventricular dysfunction in reperfused myocardium in patients with acute coronary syndrome

Masuda, A., Yoshinaga, K., Naya, M., Manabe, O., Yamada, S., Iwano, H., Okada, T., Katoh, C., Takeishi, Y., Tsutsui, H. & Tamaki, N., Jan 1 2016, In : EJNMMI Research. 6, 1, 41.

Research output: Contribution to journalArticle

Technetium Tc 99m Sestamibi
Left Ventricular Dysfunction
Acute Coronary Syndrome
Myocardium
Single-Photon Emission-Computed Tomography
1 Citation (Scopus)
Open Access
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Diabetic Retinopathy
Hypercholesterolemia
LDL Cholesterol
Therapeutics
15 Citations (Scopus)
secretin
glucagon-like peptide 1
Incretins
Glucagon-Like Peptide 1
glycohemoglobin
32 Citations (Scopus)

Activation of natural killer T cells ameliorates postinfarct cardiac remodeling and failure in mice

Sobirin, M. A., Kinugawa, S., Takahashi, M., Fukushima, A., Homma, T., Ono, T., Hirabayashi, K., Suga, T., Azalia, P., Takada, S., Taniguchi, M., Nakayama, T., Ishimori, N., Iwabuchi, K. & Tsutsui, H., Sep 1 2012, In : Circulation research. 111, 8, p. 1037-1047 11 p.

Research output: Contribution to journalArticle

Natural Killer T-Cells
Heart Failure
Myocardial Infarction
Ventricular Remodeling
Interleukin-10
30 Citations (Scopus)

Acute cardiac impairment associated with concurrent chemoradiotherapy for esophageal cancer: Magnetic resonance evaluation

Hatakenaka, M., Yonezawa, M., Nonoshita, T., Nakamura, K., Yabuuchi, H., Shioyama, Y., Nagao, M., Matsuo, Y., Kamitani, T., Higo, T., Nishikawa, K., Setoguchi, T. & Honda, H., May 1 2012, In : International Journal of Radiation Oncology Biology Physics. 83, 1

Research output: Contribution to journalArticle

impairment
Chemoradiotherapy
Esophageal Neoplasms
magnetic resonance
Magnetic Resonance Spectroscopy
32 Citations (Scopus)

Acute hemodynamic effects of adaptive servo-ventilation in patients with heart failure

Yamada, S., Sakakibara, M., Yokota, T., Kamiya, K., Asakawa, N., Iwano, H., Yamada, S., Oba, K. & Tsutsui, H., May 1 2013, In : Circulation Journal. 77, 5, p. 1214-1220 7 p.

Research output: Contribution to journalArticle

Ventilation
Heart Failure
Hemodynamics
Pulmonary Wedge Pressure
Mitral Valve Insufficiency
46 Citations (Scopus)

Adaptive servo-ventilation therapy for patients with chronic heart failure in a confirmatory, multicenter, randomized, controlled study

SAVIOR-C Investigators, Jan 1 2015, In : Circulation Journal. 79, 5, p. 982-990 9 p.

Research output: Contribution to journalArticle

Ventilation
Heart Failure
Stroke Volume
Brain Natriuretic Peptide
Guidelines
8 Citations (Scopus)

Adenosine triphosphate stress echocardiography in the detection of myocardial ischemia

Fukai, T., Koyanagi, S., Tashiro, H., Ichiki, T., Tsutsui, H., Matsumoto, T. & Takeshita, A., Nov 8 1995, In : American Journal of Cardiac Imaging. 9, 4, p. 237-244 8 p.

Research output: Contribution to journalArticle

Stress Echocardiography
Myocardial Ischemia
Adenosine Triphosphate
Coronary Artery Disease
Myocardial Infarction
12 Citations (Scopus)

Administration of unfractionated heparin with prolonged fasting could reduce physiological 18F-fluorodeoxyglucose uptake in the heart

Masuda, A., Naya, M., Manabe, O., Magota, K., Yoshinaga, K., Tsutsui, H. & Tamaki, N., Jan 1 2016, In : Acta Radiologica. 57, 6, p. 661-668 8 p.

Research output: Contribution to journalArticle

Fluorodeoxyglucose F18
Heparin
Fasting
Heart Diseases
Nonesterified Fatty Acids
9 Citations (Scopus)
Escin
Guanosine
Guanosine Triphosphate
Adrenergic Receptors
Rats
348 Citations (Scopus)

Adverse outcomes of interrupted precordial compression during automated defibrillation

Nakamura, R., Egashira, K., Machida, Y., Hayashidani, S., Takeya, M., Utsumi, H., Tsutsui, H. & Takeshita, A., Jul 16 2002, In : Circulation. 106, 3, p. 368-372 5 p.

Research output: Contribution to journalArticle

Shock
Defibrillators
Cardiopulmonary Resuscitation
Thorax
Ventricular Fibrillation
29 Citations (Scopus)

Afferent vagal nerve stimulation resets baroreflex neural arc and inhibits sympathetic nerve activity

Saku, K., Kishi, T., Sakamoto, K., Hosokawa, K., sakamoto, T., Murayama, Y., Kakino, T., Ikeda, M., Ide, T. & Sunagawa, K., Jan 1 2014, In : Physiological Reports. 2, 9, e12136.

Research output: Contribution to journalArticle

Vagus Nerve Stimulation
Baroreflex
Arterial Pressure
Splanchnic Nerves
Carotid Sinus
24 Citations (Scopus)

Allograft inflammatory factor-1 augments macrophage phagocytotic activity and accelerates the progression of atherosclerosis in ApoE-/- mice

Mishima, T., Iwabuchi, K., Fujii, S., Tanaka, S. Y., Ogura, H., Watano-Miyata, K., Ishimori, N., Andoh, Y., Nakai, Y., Iwabuchi, C., Ato, M., Kitabatake, A., Tsutsui, H. & Onoé, K., Feb 1 2008, In : International journal of molecular medicine. 21, 2, p. 181-187 7 p.

Research output: Contribution to journalArticle

Apolipoproteins E
Allografts
Atherosclerosis
Macrophages
Phagocytosis
50 Citations (Scopus)

Allopurinol improves cardiac dysfunction after ischemia-reperfusion via reduction of oxidative stress in isolated perfused rat hearts

Kinugasa, Y., Ogino, K., Furuse, Y., Shiomi, T., Tsutsui, H., Yamamoto, T., Igawa, O., Hisatome, I. & Shigemasa, C., Sep 1 2003, In : Circulation Journal. 67, 9, p. 781-787 7 p.

Research output: Contribution to journalArticle

Allopurinol
Reperfusion
Oxidative Stress
Ischemia
Reperfusion Injury
28 Citations (Scopus)

Alterations in sarcoplasmic reticulum calcium-storing proteins in pressure-overload cardiac hypertrophy

Tsutsui, H., Ishibashi, Y., Imanaka-Yoshida, K., Yamamoto, S., Yoshida, T., Sugimachi, M., Urabe, Y. & Takeshita, A., Feb 20 1997, In : American Journal of Physiology - Heart and Circulatory Physiology. 272, 1 41-1

Research output: Contribution to journalArticle

Cardiomegaly
Sarcoplasmic Reticulum
Calreticulin
Calcium
Pressure
58 Citations (Scopus)

Amiodarone protects cardiac myocytes against oxidative injury by its free radical scavenging action

Ide, T., Tsutsui, H., Kinugawa, S., Utsumi, H. & Takeshita, A., Aug 17 1999, In : Circulation. 100, 7, p. 690-692 3 p.

Research output: Contribution to journalArticle

Amiodarone
Cardiac Myocytes
Free Radicals
Wounds and Injuries
Reactive Oxygen Species
1 Citation (Scopus)

A new method to estimate pulmonary vascular resistance using diastolic pulmonary artery-right ventricular pressure gradients derived from continuous-wave Doppler velocity measurements of pulmonary regurgitation

Kaga, S., Mikami, T., Murayama, M., Okada, K., Masauzi, N., Nakabachi, M., Nishino, H., Yokoyama, S., Nishida, M., Hayashi, T., Murai, D., Iwano, H., Sakakibara, M., Yamada, S. & Tsutsui, H., Jan 1 2017, In : International Journal of Cardiovascular Imaging. 33, 1, p. 31-38 8 p.

Research output: Contribution to journalArticle

Pulmonary Valve Insufficiency
Ventricular Pressure
Vascular Resistance
Pulmonary Artery
Cardiac Catheterization
8 Citations (Scopus)

Angiotensin converting enzyme inhibitors attenuated the expression of G-protein coupled receptor kinases in heart failure patients

Oyama, N., Urasawa, K., Kaneta, S., Sakai, H., Saito, T., Takagi, C., Yoshida, I., Kitabatake, A. & Tsutsui, H., Mar 7 2006, In : Circulation Journal. 70, 3, p. 362-363 2 p.

Research output: Contribution to journalArticle

G-Protein-Coupled Receptor Kinases
Angiotensin-Converting Enzyme Inhibitors
Heart Failure
Messenger RNA
Lymphocytes
23 Citations (Scopus)

Angiotensin II can directly induce mitochondrial dysfunction, decrease oxidative fibre number and induce atrophy in mouse hindlimb skeletal muscle

Kadoguchi, T., Kinugawa, S., Takada, S., Fukushima, A., Furihata, T., Homma, T., Masaki, Y., Mizushima, W., Nishikawa, M., Takahashi, M., Yokota, T., Matsushima, S., Okita, K. & Tsutsui, H., Mar 1 2015, In : Experimental Physiology. 100, 3, p. 312-322 11 p.

Research output: Contribution to journalArticle

Hindlimb
Angiotensin II
Atrophy
Skeletal Muscle
Citrate (si)-Synthase
32 Citations (Scopus)

Angiotensin II-induced reduction in exercise capacity is associated with increased oxidative stress in skeletal muscle

Inoue, N., Kinugawa, S., Suga, T., Yokota, T., Hirabayashi, K., Kuroda, S., Okita, K. & Tsutsui, H., Mar 1 2012, In : American Journal of Physiology - Heart and Circulatory Physiology. 302, 5, p. H1202-H1210

Research output: Contribution to journalArticle

Angiotensin II
Skeletal Muscle
Oxidative Stress
NADPH Oxidase
Respiration
28 Citations (Scopus)

Angiotensin II receptor blocker improves the lowered exercise capacity and impaired mitochondrial function of the skeletal muscle in type 2 diabetic mice

Takada, S., Kinugawa, S., Hirabayashi, K., Suga, T., Yokota, T., Takahashi, M., Fukushima, A., Homma, T., Ono, T., Sobirin, M. A., Masaki, Y., Mizushima, W., Kadoguchi, T., Okita, K. & Tsutsui, H., Apr 1 2013, In : Journal of Applied Physiology. 114, 7, p. 844-857 14 p.

Research output: Contribution to journalArticle

Angiotensin Receptor Antagonists
High Fat Diet
Skeletal Muscle
NADPH Oxidase
Diet
57 Citations (Scopus)

Angiotensin II type 1 receptor blocker attenuates myocardial remodelling and preserves diastolic function in diabetic heart

Tsutsui, H., Matsushima, S., Kinugawa, S., Ide, T., Inoue, N., Ohta, Y., Yokota, T., Hamaguchi, S. & Sunagawa, K., May 1 2007, In : Hypertension Research. 30, 5, p. 439-449 11 p.

Research output: Contribution to journalArticle

Angiotensin II Type 1 Receptor Blockers
Diabetes Mellitus
Connective Tissue Growth Factor
Angiotensin II
Arterial Pressure
3 Citations (Scopus)

Angiotensin receptor neprilysin inhibitor in Japanese patients with heart failure and reduced ejection fraction: Baseline characteristics and treatment of PARALLEL-HF trial

Tsutsui, H., Momomura, S. I., Saito, Y., Ito, H., Yamamoto, K., Ohishi, T., Okino, N., Kitamura, T. & Guo, W., Jan 1 2018, In : Circulation Journal. 82, 10, p. 2575-2583 9 p.

Research output: Contribution to journalArticle

Neprilysin
Angiotensin Receptors
Heart Failure
Therapeutics
Registries
10 Citations (Scopus)

Anticoagulation management in the perioperative phase of implantable cardioverter defbrillator implantation

Yokoshiki, H., Mitsuyama, H., Watanabe, M., Mizukami, K., Matsui, Y. & Tsutsui, H., Aug 2 2013, In : Circulation Journal. 77, 8, p. 2003-2008 6 p.

Research output: Contribution to journalArticle

Heparin
Implantable Defibrillators
Hemorrhage
Warfarin
Cardiac Tamponade
174 Citations (Scopus)

Anti-Monocyte Chemoattractant Protein-1 Gene Therapy Attenuates Left Ventricular Remodeling and Failure After Experimental Myocardial Infarction

Hayashidani, S., Tsutsui, H., Shiomi, T., Ikeuchi, M., Matsusaka, H., Suematsu, N., Wen, J., Egashira, K. & Takeshita, A., Oct 28 2003, In : Circulation. 108, 17, p. 2134-2140 7 p.

Research output: Contribution to journalArticle

Ventricular Remodeling
Chemokine CCL2
Genetic Therapy
Myocardial Infarction
Ligation
9 Citations (Scopus)
glimepiride
secretin
Incretins
noninsulin-dependent diabetes mellitus
glycohemoglobin

Architecture of the Japan ischemic heart disease multimodal prospective data acquisition for precision treatment (J-IMPACT) system

Matoba, T., Kohro, T., Fujita, H., Nakayama, M., Kiyosue, A., Miyamoto, Y., Nishimura, K., Hashimoto, H., Antoku, Y., Nakashima, N., Ohe, K., Ogawa, H., Tsutsui, H. & Nagai, R., Jan 1 2019, In : International heart journal. 60, 2, p. 264-270 7 p.

Research output: Contribution to journalArticle

Open Access
Percutaneous Coronary Intervention
Myocardial Ischemia
Japan
Coronary Angiography
Information Systems
10 Citations (Scopus)

Arterial pressure lability is improved by sodium-glucose cotransporter 2 inhibitor in streptozotocin-induced diabetic rats

Yoshikawa, T., Kishi, T., shinohara, K., Takesue, K., Shibata, R., Sonoda, N., Inoguchi, T., Sunagawa, K., Tsutsui, H. & Hirooka, Y., Jul 1 2017, In : Hypertension Research. 40, 7, p. 646-651 6 p.

Research output: Contribution to journalArticle

Sodium-Glucose Transport Proteins
Streptozocin
Arterial Pressure
Insulin
Diabetes Mellitus

Assessment of coronary flow velocity reserve in the left main trunk using phase-contrast MR imaging at 3T: Comparison with 15O-labeled water positron emission tomography

Kikuchi, Y., Naya, M., Manabe, N. O., Manabe, O., Sugimori, H., Kudo, K., Kato, F., Aikawa, T., Tsutsui, H., Tamaki, N. & Shirato, H., Jan 1 2019, In : Magnetic Resonance in Medical Sciences. 18, 2, p. 134-141 8 p.

Research output: Contribution to journalArticle

Open Access
Positron-Emission Tomography
Coronary Artery Disease
Water
Arteries
Contrast Media
15 Citations (Scopus)

Assessment of quality of life during long-term treatment of tolvaptan in refractory heart failure: Design and rationale of the AQUA-TLV study

Imamura, T., Kinugawa, K., Ohtani, T., Sakata, Y., Higo, T., Kinugawa, S., Tsutsui, H., Sunagawa, K. & Komuro, I., 2014, In : International heart journal. 55, 3, p. 264-267 4 p.

Research output: Contribution to journalArticle

Heart Failure
Quality of Life
Japan
Therapeutics
Furosemide
9 Citations (Scopus)

Association of contrast-induced nephropathy with risk of adverse clinical outcomes in patients with cardiac catheterization: From the CINC-J study

on behalf of the CINC-J study investigators, Jan 15 2017, In : International Journal of Cardiology. 227, p. 424-429 6 p.

Research output: Contribution to journalArticle

Cardiac Catheterization
Kidney
Anemia
Renal Dialysis
Creatinine

Association of peripartum troponin i levels with left ventricular relaxation in women with hypertensive disorders of pregnancy

Umazume, T., Yamada, S., Yamada, T., Ishikawa, S., Furuta, I., Iwano, H., Murai, D., Hayashi, T., Okada, K., Morikawa, M., Tsutsui, H. & Minakami, H., Jan 1 2018, In : Open Heart. 5, 2, e000829.

Research output: Contribution to journalArticle

Peripartum Period
Troponin
Postpartum Period
Pregnancy
Troponin I
2 Citations (Scopus)
Balloon Angioplasty
Pulmonary Hypertension
Hemodynamics
Lung
Angioplasty
10 Citations (Scopus)

Baroreflex failure increases the risk of pulmonary edema in conscious rats with normal left ventricular function

Sakamoto, K., Hosokawa, K., Saku, K., sakamoto, T., Tobushi, T., Oga, Y., Kishi, T., Ide, T. & Sunagawa, K., Jan 1 2016, In : American Journal of Physiology - Heart and Circulatory Physiology. 310, 2, p. H199-H205

Research output: Contribution to journalArticle

Baroreflex
Pulmonary Edema
Left Ventricular Function
Atrial Pressure
Salts

Baseline demographics and clinical characteristics in the all nippon af in the elderly (ANAFIE) registry

Koretsune, Y., Yamashita, T., Akao, M., Atarashi, H., Ikeda, T., Okumura, K., Shimizu, W., Tsutsui, H., Toyoda, K., Hirayama, A., Yasaka, M., Yamaguchi, T., Teramukai, S., Kimura, T., Kaburagi, J., Takita, A. & Inoue, H., Jan 1 2019, In : Circulation Journal. 83, 7, p. 1538-1545 8 p.

Research output: Contribution to journalArticle

Open Access
Registries
Demography
Anticoagulants
Atrial Fibrillation
Prospective Studies
15 Citations (Scopus)

Bionic baroreceptor corrects postural hypotension in rats with impaired baroreceptor

Hosokawa, K., Ide, T., Tobushi, T., Sakamoto, K., Onitsuka, K., sakamoto, T., Fujino, T., Saku, K. & Sunagawa, K., Sep 4 2012, In : Circulation. 126, 10, p. 1278-1285 8 p.

Research output: Contribution to journalArticle

Bionics
Orthostatic Hypotension
Pressoreceptors
Pressure
Baroreflex
79 Citations (Scopus)

Blockade of NF-κB ameliorates myocardial hypertrophy in response to chronic infusion of angiotensin II

Kawano, S., Kubota, T., Monden, Y., Kawamura, N., Tsutsui, H., Takeshita, A. & Sunagawa, K., Sep 1 2005, In : Cardiovascular research. 67, 4, p. 689-698 10 p.

Research output: Contribution to journalArticle

Angiotensin II
Hypertrophy
Phosphorylation
Chemokine CCL5
Cardiomegaly
78 Citations (Scopus)

Blockade of NF-κB improves cardiac function and survival without affecting inflammation in TNF-α-induced cardiomyopathy

Kawamura, N., Kubota, T., Kawano, S., Monden, Y., Feldman, A. M., Tsutsui, H., Takeshita, A. & Sunagawa, K., Jun 1 2005, In : Cardiovascular research. 66, 3, p. 520-529 10 p.

Research output: Contribution to journalArticle

Cardiomyopathies
Inflammation
Survival
Cytokines
Heart Failure
26 Citations (Scopus)

Body mass index can similarly predict the presence of multiple cardiovascular risk factors in middle-aged Japanese subjects as waist circumference

Satoh, H., Kishi, R. & Tsutsui, H., Jun 16 2010, In : Internal Medicine. 49, 11, p. 977-982 6 p.

Research output: Contribution to journalArticle

Waist Circumference
Body Mass Index
Adiposity
Glucose Intolerance
Dyslipidemias
70 Citations (Scopus)

Bradykinin-induced vasodilation is impaired at the atherosclerotic site but is preserved at the spastic site of human coronary arteries in vivo

Kuga, T., Egashira, K., Mohri, M., Tsutsui, H., Harasawa, Y., Urabe, Y., Ando, S., Shimokawa, H. & Takeshita, A., 1995, In : Circulation. 92, 2, p. 183-189 7 p.

Research output: Contribution to journalArticle

Muscle Spasticity
Bradykinin
Vasodilation
Coronary Vessels
Acetylcholine
15 Citations (Scopus)

Cardiac magnetic resonance performs better in the detection of functionally significant coronary artery Stenosis compared to single-photon emission computed Tomography and Dobutamine stress echocardiography

Kamiya, K., Sakakibara, M., Asakawa, N., Yamada, S., Yoshitani, T., Iwano, H., Komatsu, H., Naya, M., Chiba, S., Yamada, S., Manabe, O., Kikuchi, Y., Oyama-Manabe, N., Oba, K. & Tsutsui, H., Jan 1 2014, In : Circulation Journal. 78, 10, p. 2468-2476 9 p.

Research output: Contribution to journalArticle

Stress Echocardiography
Myocardial Perfusion Imaging
Coronary Stenosis
Single-Photon Emission-Computed Tomography
Magnetic Resonance Spectroscopy
1 Citation (Scopus)

Cardiac phase-targeted dynamic load on left ventricle differentially regulates phase-sensitive gene expressions and pathway activation

Onitsuka, K., Ide, T., Arai, S., Hata, Y., Murayama, Y., Hosokawa, K., sakamoto, T., Tobushi, T., Sakamoto, K., Fujino, T. & Sunagawa, K., Nov 1 2013, In : Journal of Molecular and Cellular Cardiology. 64, p. 30-38 9 p.

Research output: Contribution to journalArticle

Heart Ventricles
Gene Expression
Genes
Blood Pressure
Calcium-Calmodulin-Dependent Protein Kinase Type 2
1 Citation (Scopus)

Cardioprotective effect of renin–angiotensin inhibitors and β-blockers in trastuzumab-related cardiotoxicity

Ohtani, K., Ide, T., Ken-Ichi, H., Sakamoto, I., Yamashita, N., Kubo, M. & Tsutsui, H., Oct 1 2019, In : Clinical Research in Cardiology. 108, 10, p. 1128-1139 12 p.

Research output: Contribution to journalArticle

Anthracyclines
Left Ventricular Dysfunction
Breast Neoplasms
Heart Failure
Cardiotoxicity
2 Citations (Scopus)

Carotid body denervation markedly improves survival in rats with hypertensive heart failure

Fujii, K., Saku, K., Kishi, T., Oga, Y., Tohyama, T., Nishikawa, T., sakamoto, T., Ikeda, M., Ide, T., Tsutsui, H. & Sunagawa, K., Jan 1 2017, In : American Journal of Hypertension. 30, 8, p. 791-798 8 p.

Research output: Contribution to journalArticle

Carotid Body
Denervation
Heart Failure
Survival
Natriuresis
Purkinje Fibers
Catheter Ablation
Ventricular Tachycardia
Verapamil
Electrodes