Research Output 1984 2019

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2014
13 Citations (Scopus)

Relation of risk factors with response to carvedilol in heart failure with preserved ejection fraction - A report from the Japanese Diastolic Heart Failure Study (J-DHF)

Yamamoto, K., Origasa, H., Suzuki, Y., Takahashi, T., Shinozaki, T., Watanabe, T., Sakata, Y., Izumi, C., Taira, K., Hori, M., Sakata, Y., Yamaguchi, O., Mano, T., Kinugawa, K., Oki, T., Oishi, Y., Ishikawa, K., Ito, H., Kosaka, T., Izumi, T. & 64 others, Inomata, T., Fujii, K., Yoshikawa, T., Onishi, K., Maejima, Y., Isobe, M., Nakamura, T., Takahashi, T., Yasumura, Y., Nishigaki, K., Ueda, Y., Kashiwase, K., Tomo-hiro, Y., Suzuki, Y., Yoshida, J., Nariyama, J., Yuda, S., Kawagoe, T., Matsuzaki, M., Yano, M., Yamamoto, T., Tsutsui, H., Okamoto, H., Goto, D., Souma, T., Kijima, Y., Iwahashi, N., Ebina, T., Kimura, K., Nakamura, R., Okamoto, M., Yamasaki, N., Ishikawa, S., Kajiya, T., Ikeda, Y., Hoshida, S., Ishikawa, K., Kusano, K., Nakagawa, Y., Izumi, C., Yasumori, K., Nishino, M., Yamaguchi, H., Takahashi, T., Maruyama, N., Abe, H., Yasuoka, Y., Node, K., Morita, H., Uematsu, M., Fujita, M., Watanabe, T., Ono, S., Saito, Y., Horii, M., Taira, K., Shinozaki, T., Yamamoto, H., Tadehara, F., Kuwahara, M., Ohte, N., Takeda, Y., Watanabe, T. & Yamamoto, K., Jan 1 2014, In : Journal of Cardiology. 63, 6, p. 424-431 8 p.

Research output: Contribution to journalArticle

Diastolic Heart Failure
Heart Failure
Hospitalization
Prescriptions
Dilatation
5 Citations (Scopus)

Report of the American Heart Association (AHA) scientific sessions 2013, Dallas

Ishimori, N., Kinugawa, S., Yamada, S., Yokoshiki, H., Mitsuyama, H. & Tsutsui, H., Jan 1 2014, In : Circulation Journal. 78, 1, p. 51-56 6 p.

Research output: Contribution to journalArticle

Cardiology
Clinical Trials
Population
Cardiologists
1 Citation (Scopus)

Stimulus frequency differences in respiratory inhibition is negligible to optimize vagal nerve stimulation (VNS) for heart failure

Saku, K., Nishizaki, A., Kishi, T., Ide, T. & Sunagawa, K., Aug 17 2014, In : Transactions of Japanese Society for Medical and Biological Engineering. 52, p. O-84-O-85

Research output: Contribution to journalArticle

Titration
Ventilation
Rats
21 Citations (Scopus)

Striking volume intolerance is induced by mimicking arterial baroreflex failure in normal left ventricular function

Funakoshi, K., Hosokawa, K., Kishi, T., Ide, T. & Sunagawa, K., Jan 1 2014, In : Journal of Cardiac Failure. 20, 1, p. 53-59 7 p.

Research output: Contribution to journalArticle

Baroreflex
Carotid Sinus
Atrial Pressure
Left Ventricular Function
Arterial Pressure

Total left ventricular unloading markedly reduces the pressure-volume area, thereby oxygen consumption

Arimura, T., Saku, K., Kakino, T., Akashi, T., Takehara, T., Nishizaki, A., Oga, Y., Ikeda, M., Fujii, K., Ide, T., Kishi, T. & Sunagawa, K., Jan 1 2014, In : Transactions of Japanese Society for Medical and Biological Engineering. 52, p. O-548-O-549

Research output: Contribution to journalArticle

Left ventricular assist devices
Unloading
Oxygen
Hemodynamics
2013
32 Citations (Scopus)

Acute hemodynamic effects of adaptive servo-ventilation in patients with heart failure

Yamada, S., Sakakibara, M., Yokota, T., Kamiya, K., Asakawa, N., Iwano, H., Yamada, S., Oba, K. & Tsutsui, H., May 1 2013, In : Circulation Journal. 77, 5, p. 1214-1220 7 p.

Research output: Contribution to journalArticle

Ventilation
Heart Failure
Hemodynamics
Pulmonary Wedge Pressure
Mitral Valve Insufficiency
10 Citations (Scopus)

Anticoagulation management in the perioperative phase of implantable cardioverter defbrillator implantation

Yokoshiki, H., Mitsuyama, H., Watanabe, M., Mizukami, K., Matsui, Y. & Tsutsui, H., Aug 2 2013, In : Circulation Journal. 77, 8, p. 2003-2008 6 p.

Research output: Contribution to journalArticle

Heparin
Implantable Defibrillators
Hemorrhage
Warfarin
Cardiac Tamponade
1 Citation (Scopus)

Cardiac phase-targeted dynamic load on left ventricle differentially regulates phase-sensitive gene expressions and pathway activation

Onitsuka, K., Ide, T., Arai, S., Hata, Y., Murayama, Y., Hosokawa, K., sakamoto, T., Tobushi, T., Sakamoto, K., Fujino, T. & Sunagawa, K., Nov 1 2013, In : Journal of Molecular and Cellular Cardiology. 64, p. 30-38 9 p.

Research output: Contribution to journalArticle

Heart Ventricles
Gene Expression
Genes
Blood Pressure
Calcium-Calmodulin-Dependent Protein Kinase Type 2
4 Citations (Scopus)

Evaluation of chronic ischemic heart disease with myocardial perfusion and regional contraction analysis by contrast-enhanced 256-MSCT

Higuchi, K., Nagao, M., Matsuo, Y., Kamitani, T., Yonezawa, M., Jinnouchi, M., Yamasaki, Y., Abe, K., Baba, S., Mukai, Y., Higo, T., Sunagawa, K. & Honda, H., Feb 1 2013, In : Japanese Journal of Radiology. 31, 2, p. 123-132 10 p.

Research output: Contribution to journalArticle

Single-Photon Emission-Computed Tomography
Myocardial Ischemia
Myocardial Perfusion Imaging
Perfusion
Myocardial Infarction
23 Citations (Scopus)

Home-based disease management program to improve psychological status in patients with heart failure in Japan

Tsuchihashi-Makaya, M., Matsuo, H., Kakinoki, S., Takechi, S., Kinugawa, S. & Tsutsui, H., Apr 3 2013, In : Circulation Journal. 77, 4, p. 926-933 8 p.

Research output: Contribution to journalArticle

Disease Management
Japan
Heart Failure
Psychology
Anxiety
17 Citations (Scopus)

Minimal dose for effective clinical outcome and predictive factors for responsiveness to carvedilol: Japanese chronic heart failure (J-CHF) study

Okamoto, H., Hori, M., Matsuzaki, M., Tsutsui, H., Yamazaki, T., Nagai, R., Yoshikawa, T., Fujio, Y., Nonen, S., Azuma, J., Izumi, T., Ohashi, Y. & Kitabatake, A., Apr 5 2013, In : International Journal of Cardiology. 164, 2, p. 238-244 7 p.

Research output: Contribution to journalArticle

Heart Failure
Heart Rate
Disease-Free Survival
Osteopontin
Survival
10 Citations (Scopus)

Partially Silencing Brain Toll-Like Receptor 4 Prevents in Part Left Ventricular Remodeling with Sympathoinhibition in Rats with Myocardial Infarction-Induced Heart Failure

Ogawa, K., Hirooka, Y., Kishi, T., Ide, T. & Sunagawa, K., Jul 9 2013, In : PloS one. 8, 7, e69053.

Research output: Contribution to journalArticle

Toll-Like Receptor 4
Ventricular Remodeling
myocardial infarction
heart failure
Rats
21 Citations (Scopus)

Pivotal role of rho-associated kinase 2 in generating the intrinsic circadian rhythm of vascular contractility

Saito, T., Hirano, M., Ide, T., Ichiki, T., Koibuchi, N., Sunagawa, K. & Hirano, K., Jan 1 2013, In : Circulation. 127, 1, p. 104-114 11 p.

Research output: Contribution to journalArticle

rho-Associated Kinases
Circadian Rhythm
Blood Vessels
Myosin Light Chains
Myofibrils
1 Citation (Scopus)

Quantification of heterogeneity on 201Tl Gated SPECT: Evaluation of coronary artery disease

Maruoka, Y., Nagao, M., Abe, K., Baba, S., Isoda, T., Higo, T., Sunagawa, K. & Honda, H., Jan 1 2013, In : Clinical Nuclear Medicine. 38, 1

Research output: Contribution to journalArticle

Single-Photon Emission-Computed Tomography
Coronary Artery Disease
Perfusion
Coronary Angiography
American Heart Association
6 Citations (Scopus)

Relationship between impaired cardiac sympathetic activity and spatial dyssynchrony in patients with non-ischemic heart failure: Assessment by MIBG scintigraphy and tagged MRI

Yonezawa, M., Nagao, M., Abe, K., Matsuo, Y., Baba, S., Kamitani, T., Isoda, T., Maruoka, Y., Jinnouchi, M., Yamasaki, Y., Abe, K., Higo, T., Yoshiura, T. & Honda, H., Aug 1 2013, In : Journal of Nuclear Cardiology. 20, 4, p. 600-608 9 p.

Research output: Contribution to journalArticle

3-Iodobenzylguanidine
Radionuclide Imaging
Heart Failure
Mediastinum
Incidence
15 Citations (Scopus)

Sarcomere Gene Mutations Are Associated With Increased Cardiovascular Events in Left Ventricular Hypertrophy. Results From Multicenter Registration in Japan.

Fujita, T., Fujino, N., Anan, R., Tei, C., Kubo, T., Doi, Y., Kinugawa, S., Tsutsui, H., Kobayashi, S., Yano, M., Asakura, M., Kitakaze, M., Komuro, I., Konno, T., Hayashi, K., Kawashiri, M. A., Ino, H. & Yamagishi, M., Dec 1 2013, In : JACC: Heart Failure. 1, 6, p. 459-466 8 p.

Research output: Contribution to journalArticle

Sarcomeres
Left Ventricular Hypertrophy
Japan
Hypertrophic Cardiomyopathy
Mutation
4 Citations (Scopus)

Strain rate dispersion index can predict changes in left ventricular volume and adverse cardiac events following cardiac resynchronization therapy

Iwano, H., Yamada, S., Watanabe, M., Mitsuyama, H., Mizukami, K., Nishino, H., Yokoyama, S., Kaga, S., Okada, K., Nishida, M., Yokoshiki, H., Mikami, T. & Tsutsui, H., Oct 31 2013, In : Circulation Journal. 77, 11, p. 2757-2765 9 p.

Research output: Contribution to journalArticle

Cardiac Volume
Cardiac Resynchronization Therapy
Kaplan-Meier Estimate
Stroke Volume
Echocardiography
36 Citations (Scopus)

Systemic oxidative stress is associated with lower aerobic capacity and impaired skeletal muscle energy metabolism in patients withmetabolic syndrome

Yokota, T., Kinugawa, S., Yamato, M., Hirabayashi, K., Suga, T., Takada, S., Harada, K., Morita, N., Oyama-Manabe, N., Kikuchi, Y., Okita, K. & Tsutsui, H., May 1 2013, In : Diabetes care. 36, 5, p. 1341-1346 6 p.

Research output: Contribution to journalArticle

Energy Metabolism
Skeletal Muscle
Oxidative Stress
Thiobarbituric Acid Reactive Substances
Serum
11 Citations (Scopus)

The Overexpression of Twinkle Helicase Ameliorates the Progression of Cardiac Fibrosis and Heart Failure in Pressure Overload Model in Mice

Tanaka, A., Ide, T., Fujino, T., Onitsuka, K., Ikeda, M., Takehara, T., Hata, Y., Ylikallio, E., Tyynismaa, H., Suomalainen, A. & Sunagawa, K., Jun 28 2013, In : PloS one. 8, 6, e67642.

Research output: Contribution to journalArticle

heart failure
fibrosis
Mitochondrial DNA
Fibrosis
mitochondrial DNA
380 Citations (Scopus)

The survival of patients with heart failure with preserved or reduced left ventricular ejection fraction: An individual patient data meta-analysis: Meta-analysis Global Group in Chronic Heart Failure (MAGGIC)

Meta-analysis Global Group in Chronic Heart Failure (MAGGIC), Dec 20 2013, In : European heart journal. 33, 14, p. 1750-1757 8 p.

Research output: Contribution to journalArticle

Stroke Volume
Meta-Analysis
Heart Failure
Survival
Confidence Intervals
3 Citations (Scopus)

Ventricular fibrillation after bortezomib therapy in a patient with systemic amyloidosis

Yamasaki, S., Muta, T., Higo, T., Kusumoto, H., Zaitsu, E., Miyamoto, T., Oda, Y. & Akashi, K., Sep 16 2013, In : Hematology Reports. 5, 3, p. 39-42 4 p.

Research output: Contribution to journalArticle

Ventricular Fibrillation
Amyloidosis
Amiodarone
Cardiopulmonary Resuscitation
Therapeutics
2012
Temperance
Smoking Cessation
Sleep
Chronic Disease
Heart Failure
31 Citations (Scopus)

Activation of natural killer T cells ameliorates postinfarct cardiac remodeling and failure in mice

Sobirin, M. A., Kinugawa, S., Takahashi, M., Fukushima, A., Homma, T., Ono, T., Hirabayashi, K., Suga, T., Azalia, P., Takada, S., Taniguchi, M., Nakayama, T., Ishimori, N., Iwabuchi, K. & Tsutsui, H., Sep 1 2012, In : Circulation research. 111, 8, p. 1037-1047 11 p.

Research output: Contribution to journalArticle

Natural Killer T-Cells
Heart Failure
Myocardial Infarction
Ventricular Remodeling
Interleukin-10
29 Citations (Scopus)

Acute cardiac impairment associated with concurrent chemoradiotherapy for esophageal cancer: Magnetic resonance evaluation

Hatakenaka, M., Yonezawa, M., Nonoshita, T., Nakamura, K., Yabuuchi, H., Shioyama, Y., Nagao, M., Matsuo, Y., Kamitani, T., Higo, T., Nishikawa, K., Setoguchi, T. & Honda, H., May 1 2012, In : International Journal of Radiation Oncology Biology Physics. 83, 1

Research output: Contribution to journalArticle

impairment
Chemoradiotherapy
Esophageal Neoplasms
magnetic resonance
Magnetic Resonance Spectroscopy
15 Citations (Scopus)

Bionic baroreceptor corrects postural hypotension in rats with impaired baroreceptor

Hosokawa, K., Ide, T., Tobushi, T., Sakamoto, K., Onitsuka, K., sakamoto, T., Fujino, T., Saku, K. & Sunagawa, K., Sep 4 2012, In : Circulation. 126, 10, p. 1278-1285 8 p.

Research output: Contribution to journalArticle

Bionics
Orthostatic Hypotension
Pressoreceptors
Pressure
Baroreflex
12 Citations (Scopus)

Effect of mitochondrial transcription factor a overexpression on motor neurons in amyotrophic lateral sclerosis model mice

Morimoto, N., Miyazaki, K., Kurata, T., Ikeda, Y., Matsuura, T., Kang, D., Ide, T. & Abe, K., Jun 1 2012, In : Journal of Neuroscience Research. 90, 6, p. 1200-1208 9 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Motor Neurons
Transcription Factors
Mitochondrial DNA
Oxidative Stress
55 Citations (Scopus)

Effect of multiple set on intramuscular metabolic stress during low-intensity resistance exercise with blood flow restriction

Suga, T., Okita, K., Takada, S., Omokawa, M., Kadoguchi, T., Yokota, T., Hirabayashi, K., Takahashi, M., Morita, N., Horiuchi, M., Kinugawa, S. & Tsutsui, H., Nov 1 2012, In : European Journal of Applied Physiology. 112, 11, p. 3915-3920 6 p.

Research output: Contribution to journalArticle

Physiological Stress
Exercise
Healthy Volunteers
Magnetic Resonance Spectroscopy
Muscles
9 Citations (Scopus)

High-fat diet-induced obesity and insulin resistance were ameliorated via enhanced fecal bile acid excretion in tumor necrosis factor-alpha receptor knockout mice

Yamato, M., Shiba, T., Ide, T., Seri, N., Kudo, W., Ando, M., Yamada, K-I., Kinugawa, S. & Tsutsui, H., Jan 1 2012, In : Molecular and cellular biochemistry. 359, 1-2, p. 161-167 7 p.

Research output: Contribution to journalArticle

Tumor Necrosis Factor Receptors
High Fat Diet
Nutrition
Bile Acids and Salts
Knockout Mice
33 Citations (Scopus)

Induction of cardiac fibrosis by β-blocker in G protein-independent and G protein-coupled receptor kinase 5/β-arrestin2-dependent signaling pathways

Michio, N., Chikura, S., Watari, K., Mizuno, N., Mochinaga, K., Mangmool, S., Satoru, K., Ohdo, S., Sato, Y., Ide, T., Nishida, M. & Kurose, H., Oct 12 2012, In : Journal of Biological Chemistry. 287, 42, p. 35669-35677 9 p.

Research output: Contribution to journalArticle

G-Protein-Coupled Receptor Kinase 5
Metoprolol
GTP-Binding Proteins
Fibrosis
Arrestin
99 Citations (Scopus)

Interleukin-17A deficiency accelerates unstable atherosclerotic plaque formation in apolipoprotein e-deficient mice

Danzaki, K., Matsui, Y., Ikesue, M., Ohta, D., Ito, K., Kanayama, M., Kurotaki, D., Morimoto, J., Iwakura, Y., Yagita, H., Tsutsui, H. & Uede, T., Feb 1 2012, In : Arteriosclerosis, thrombosis, and vascular biology. 32, 2, p. 273-280 8 p.

Research output: Contribution to journalArticle

Interleukin-17
Apolipoproteins
Atherosclerotic Plaques
High Fat Diet
Apolipoproteins E
14 Citations (Scopus)

Leg heating using far infra-red radiation in patients with chronic heart failure acutely improves the hemodynamics, vascular endothelial function, and oxidative stress

Inoue, S., Takemoto, M., Chishaki, A., Ide, T., Nishizaka, M., Miyazono, M., Sawatari, H. & Sunagawa, K., 2012, In : Internal Medicine. 51, 17, p. 2263-2270 8 p.

Research output: Contribution to journalArticle

Heating
Blood Vessels
Leg
Oxidative Stress
Heart Failure
17 Citations (Scopus)

Recombinant mitochondrial transcription factor A protein inhibits nuclear factor of activated T cells signaling and attenuates pathological hypertrophy of cardiac myocytes

Fujino, T., Ide, T., Yoshida, M., Onitsuka, K., Tanaka, A., Hata, Y., Nishida, M., Takehara, T., Kanemaru, T., Kitajima, N., Takazaki, S., Kurose, H., Kang, D. & Sunagawa, K., Jul 1 2012, In : Mitochondrion. 12, 4, p. 449-458 10 p.

Research output: Contribution to journalArticle

NFATC Transcription Factors
Cardiac Myocytes
Hypertrophy
Mitochondrial DNA
Proteins
67 Citations (Scopus)

Type II NKT cells stimulate diet-induced obesity by mediating adipose tissue inflammation, steatohepatitis and insulin resistance

Satoh, M., Andoh, Y., Clingan, C. S., Ogura, H., Fujii, S., Eshima, K., Nakayama, T., Taniguchi, M., Hirata, N., Ishimori, N., Tsutsui, H., Onoé, K. & Iwabuchi, K., Feb 22 2012, In : PloS one. 7, 2, e30568.

Research output: Contribution to journalArticle

Natural Killer T-Cells
T-cells
natural killer cells
Fatty Liver
Nutrition
14 Citations (Scopus)

Usefulness of non-contact mapping for radiofrequency catheter ablation of inappropriate sinus tachycardia: New procedural strategy and long-term clinical outcome

Takemoto, M., Mukai, Y., Inoue, S., Matoba, T., Nishizaka, M., Ide, T., Chishaki, A. & Sunagawa, K., Feb 23 2012, In : Internal Medicine. 51, 4, p. 357-362 6 p.

Research output: Contribution to journalArticle

Sinus Tachycardia
Catheter Ablation
Heart Rate
Ambulatory Electrocardiography
Exercise Tolerance
2011

Disease management program and cardiac rehabilitation for patients with heart failure

Makaya, M. & Tsutsui, H., Mar 15 2011, In : Respiration and Circulation. 59, 3, p. 267-274 8 p.

Research output: Contribution to journalArticle

Disease Management
Heart Failure
Cardiac Rehabilitation
37 Citations (Scopus)

Heterologous down-regulation of angiotensin type 1 receptors by purinergic P2Y2 receptor stimulation through S-nitrosylation of NF-κB

Nishida, M., Ogushi, M., Suda, R., Toyotaka, M., Saiki, S., Kitajima, N., Michio, N., Kim, K. M., Ide, T., Sato, Y., Inoue, K. & Kurose, H., Apr 19 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 16, p. 6662-6667 6 p.

Research output: Contribution to journalArticle

Purinergic P2Y2 Receptors
Angiotensin Type 1 Receptor
Down-Regulation
Adenosine Triphosphate
Arrestins
45 Citations (Scopus)

Hyperuricemia predicts adverse outcomes in patients with heart failure

Hamaguchi, S., Furumoto, T., Tsuchihashi-Makaya, M., Goto, K., Goto, D., Yokota, T., Kinugawa, S., Yokoshiki, H., Takeshita, A. & Tsutsui, H., Sep 1 2011, In : International Journal of Cardiology. 151, 2, p. 143-147 5 p.

Research output: Contribution to journalArticle

Hyperuricemia
Heart Failure
Uric Acid
Cause of Death
Confidence Intervals
3 Citations (Scopus)

Nifedipine treatment reduces brain damage after transient focal ischemia, possibly through its antioxidative effects

Yamato, M., Shiba, T., Ide, T., Honda, Y., Yamada, K-I. & Tsutsui, H., Jul 1 2011, In : Hypertension Research. 34, 7, p. 840-845 6 p.

Research output: Contribution to journalArticle

Nifedipine
Ischemia
Middle Cerebral Artery Infarction
Brain
Brain Ischemia
6 Citations (Scopus)

Rationale and design of the Japanese Heart Failure Outpatients Disease Management and Cardiac Evaluation (J-HOMECARE)

Tsuchihashi-Makaya, M., Matsuo, H., Kakinoki, S., Takechi, S. & Tsutsui, H., Sep 1 2011, In : Journal of Cardiology. 58, 2, p. 165-172 8 p.

Research output: Contribution to journalArticle

Disease Management
Outpatients
Heart Failure
Anxiety
Quality of Life
3 Citations (Scopus)

Successful termination of recurrent ventricular arrhythmias by adaptive servo-ventilation in a patient with heart failure

Yamada, S., Sakakibara, M., Matsushima, S., Saito, A., Homma, T., Fukushima, A., Masaki, Y., Watanabe, M., Mitsuyama, H., Yokoshiki, H. & Tsutsui, H., Apr 1 2011, In : Journal of Cardiology Cases. 3, 2

Research output: Contribution to journalArticle

Ventricular Tachycardia
Ventilation
Cardiac Arrhythmias
Respiration
Heart Failure
40 Citations (Scopus)

TRPC3-mediated Ca2+ influx contributes to Rac1-mediated production of reactive oxygen species in MLP-deficient mouse hearts

Kitajima, N., Watanabe, K., Morimoto, S., Sato, Y., Kiyonaka, S., Hoshijima, M., Ikeda, Y., Michio, N., Ide, T., Mori, Y., Kurose, H. & Nishida, M., May 27 2011, In : Biochemical and Biophysical Research Communications. 409, 1, p. 108-113 6 p.

Research output: Contribution to journalArticle

Dilated Cardiomyopathy
Calcium-Calmodulin-Dependent Protein Kinases
Reactive Oxygen Species
NADPH Oxidase
Calmodulin
2010
11 Citations (Scopus)

Discharge use of angiotensin receptor blockers provides comparable effects with angiotensin-converting enzyme inhibitors on outcomes in patients hospitalized for heart failure

Tsuchihashi-Makaya, M., Furumoto, T., Kinugawa, S., Hamaguchi, S., Goto, K., Goto, D., Yamada, S., Yokoshiki, H., Takeshita, A. & Tsutsui, H., Mar 1 2010, In : Hypertension Research. 33, 3, p. 197-202 6 p.

Research output: Contribution to journalArticle

Angiotensin Receptor Antagonists
Angiotensin-Converting Enzyme Inhibitors
Heart Failure
Left Ventricular Dysfunction
Diabetes Mellitus
71 Citations (Scopus)

High mitochondrial DNA copy number has detrimental effects in mice

Ylikallio, E., Tyynismaa, H., Tsutsui, H., Ide, T. & Suomalainen, A., Apr 22 2010, In : Human Molecular Genetics. 19, 13, p. 2695-2705 11 p., ddq163.

Research output: Contribution to journalArticle

Mitochondrial DNA
Electron Transport
Mitochondrial Diseases
Bromodeoxyuridine
DNA Replication
154 Citations (Scopus)

Natural killer T cells are involved in adipose tissues inflammation and glucose intolerance in diet-induced obese mice

Ohmura, K., Ishimori, N., Ohmura, Y., Tokuhara, S., Nozawa, A., Horii, S., Andoh, Y., Fujii, S., Iwabuchi, K., Onoé, K. & Tsutsui, H., Jan 1 2010, In : Arteriosclerosis, thrombosis, and vascular biology. 30, 2, p. 193-199 7 p.

Research output: Contribution to journalArticle

Obese Mice
Natural Killer T-Cells
Glucose Intolerance
Adipose Tissue
Diet
32 Citations (Scopus)

Overexpression of mitochondrial transcription factor A (TFAM) ameliorates delayed neuronal death due to transient forebrain ischemia in mice

Hokari, M., Kuroda, S., Kinugawa, S., Ide, T., Tsutsui, H. & Iwasaki, Y., Aug 1 2010, In : Neuropathology. 30, 4, p. 401-407 7 p.

Research output: Contribution to journalArticle

Prosencephalon
Transgenic Mice
Ischemia
Common Carotid Artery
Hippocampal CA1 Region
62 Citations (Scopus)

Phosphorylation of TRPC6 channels at Thr69 is required for anti-hypertrophic effects of phosphodiesterase 5 inhibition

Nishida, M., Watanabe, K., Sato, Y., Michio, N., Kitajima, N., Ide, T., Inoue, R. & Kurose, H., Apr 23 2010, In : Journal of Biological Chemistry. 285, 17, p. 13244-13253 10 p.

Research output: Contribution to journalArticle

Type 5 Cyclic Nucleotide Phosphodiesterases
Phosphorylation
Cyclic GMP-Dependent Protein Kinases
Cardiomegaly
Chemical activation
15 Citations (Scopus)

Ribonucleotide reductase is not limiting for mitochondrial DNA copy number in mice

Ylikallio, E., Page, J. L., Xu, X., Lampinen, M., Bepler, G., Ide, T., Tyynismaa, H., Weiss, R. S. & Suomalainen, A., Dec 1 2010, In : Nucleic acids research. 38, 22, p. 8208-8218 11 p.

Research output: Contribution to journalArticle

Ribonucleotide Reductases
Mitochondrial DNA
Deoxyribonucleosides
Maintenance
Mammals

Successful adaptive servo-ventilation for patients with acute cardiogenic pulmonary edema due to severe aortic stenosis

Sakakibara, M., Yamada, S., Matsushima, S., Saito, A., Masaki, Y., Honma, T., Kubota, S., Matsui, Y. & Tsutsui, H., Oct 1 2010, In : Journal of Cardiology Cases. 2, 2

Research output: Contribution to journalArticle

Aortic Valve Stenosis
Pulmonary Edema
Ventilation
Hemodynamics
Noninvasive Ventilation
73 Citations (Scopus)

Tenascin-C may aggravate left ventricular remodeling and function after myocardial infarction in mice

Nishioka, T., Onishi, K., Shimojo, N., Nagano, Y., Matsusaka, H., Ikeuchi, M., Ide, T., Tsutsui, H., Hiroe, M., Yoshida, T. & Imanaka-Yoshida, K., Mar 1 2010, In : American Journal of Physiology - Heart and Circulatory Physiology. 298, 3

Research output: Contribution to journalArticle

Tenascin
Ventricular Remodeling
Left Ventricular Function
Myocardial Infarction
Myocardium
23 Citations (Scopus)

Up-regulation of type 2 iodothyronine deiodinase in dilated cardiomyopathy

Wang, Y. Y., Morimoto, S., Du, C. K., Lu, Q. W., Zhan, D. Y., Tsutsumi, T., Ide, T., Miwa, Y., Takahashi, F. & Sasaguri, T., Sep 1 2010, In : Cardiovascular research. 87, 4, p. 636-646 11 p.

Research output: Contribution to journalArticle

Iodide Peroxidase
Dilated Cardiomyopathy
Up-Regulation
Thyroid Hormones
Propylthiouracil