Department of Basic Medicine

Research Output 1980 2019

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2019

2,5-Dimethylcelecoxib prevents isoprenaline-induced cardiomyocyte hypertrophy and cardiac fibroblast activation by inhibiting Akt-mediated GSK-3 phosphorylation

Morishige, S., Takahashi-Yanaga, F., Ishikane, S., arioka, M., Igawa, K., Kuroo, A., Tomooka, K., Shiose, A. & Sasaguri, T., Oct 1 2019, In : Biochemical Pharmacology. 168, p. 82-90 9 p.

Research output: Contribution to journalArticle

Celecoxib
Glycogen Synthase Kinase 3
Phosphorylation
Cardiomegaly
Fibroblasts

A case of autonomous cortisol secretion in a patient with subclinical Cushing's syndrome, GNAS mutation, and paradoxical cortisol response to dexamethasone

Sakaguchi, C., Ashida, K., Kouhashi, K., Ohe, K., Fujii, Y., Yano, S., matsuda, Y., Sakamoto, S., Sakamoto, R., Oda, Y., Nomura, M. & Ogawa, Y., Jan 22 2019, In : BMC Endocrine Disorders. 19, 1, 13.

Research output: Contribution to journalArticle

Cushing Syndrome
Dexamethasone
Hydrocortisone
Mutation
Oral Administration

aCGH Analysis of Predictive Biomarkers for Response to Bevacizumab plus Oxaliplatin- or Irinotecan-Based Chemotherapy in Patients with Metastatic Colorectal Cancer

Fujita, Y., Taguri, M., Yamazaki, K., Tsurutani, J., Sakai, K., Tsushima, T., Nagase, M., Tamagawa, H., Ueda, S., Tamura, T., Tsuji, Y., Murata, K., Taira, K., Denda, T., Moriwaki, T., Funai, S., Nakajima, T. E., Muro, K., Tsuji, A., Yoshida, M. & 11 othersSuyama, K., Kurimoto, T., Sugimoto, N., Baba, E., Seki, N., Sato, M., Shimura, T., Boku, N., Hyodo, I., Yamanaka, T. & Nishio, K., Mar 1 2019, In : Oncologist. 24, 3, p. 327-337 11 p.

Research output: Contribution to journalArticle

irinotecan
oxaliplatin
Comparative Genomic Hybridization
Colorectal Neoplasms
Biomarkers
1 Citation (Scopus)

A Clinicopathological and Prognostic Analysis of PD-L2 Expression in Surgically Resected Primary Lung Squamous Cell Carcinoma

Matsubara, T., Takada, K., Azuma, K., Takamori, S., Toyokawa, G., Haro, A., Osoegawa, A., Tagawa, T., Kawahara, A., Akiba, J., Okamoto, I., Nakanishi, Y., Oda, Y., Hoshino, T. & Maehara, Y., Jun 15 2019, In : Annals of Surgical Oncology. 26, 6, p. 1925-1933 9 p.

Research output: Contribution to journalArticle

Squamous Cell Carcinoma
Ligands
Lung
CD274 Antigen
Immunotherapy

A highly efficient method for concentrating DNA from river water by combined coagulation and foam separation

Suzuki, Y., Imafuku, Y., Nishiyama, M., Teranishi, K., Jikumaru, A., Nukazawa, K. & Ogura, Y., Jan 1 2019, (Accepted/In press) In : Separation Science and Technology (Philadelphia).

Research output: Contribution to journalArticle

Coagulation
Foams
DNA
Rivers
Water

Analysis of systemic lupus erythematosus-related interstitial pneumonia: a retrospective multicentre study

Enomoto, N., Egashira, R., Tabata, K., Hashisako, M., Kitani, M., Waseda, Y., Ishizuka, T., Watanabe, S., Kasahara, K., Izumi, S., Shiraki, A., Miyamoto, A., Kishi, K., Kishaba, T., Sugimoto, C., Inoue, Y., Kataoka, K., Kondoh, Y., Tsuchiya, Y., Baba, T. & 4 othersSugiura, H., Tanaka, T., Sumikawa, H. & Suda, T., Dec 1 2019, In : Scientific reports. 9, 1, 7355.

Research output: Contribution to journalArticle

Open Access
Interstitial Lung Diseases
Systemic Lupus Erythematosus
Multicenter Studies
Retrospective Studies
Tomography

Arsenate and microbial dynamics in different phosphorus regimes of the subtropical Pacific Ocean

Hashihama, F., Suwa, S., Kanda, J., Ehama, M., Sakuraba, R., Kinouchi, S., Sato, M., Yamaguchi, T., Saito, H., Ogura, Y., Hayashi, T., Mori, H., Kurokawa, K., Suzuki, S. & Hamasaki, K., Sep 1 2019, In : Progress in Oceanography. 176, 102115.

Research output: Contribution to journalArticle

arsenates
arsenate
Pacific Ocean
phosphate
phosphates

A simple method for semi-automatic readjustment for positioning in post-mortem head computed tomography imaging

Kawazoe, Y., Morishita, J., Matsunobu, Y., Okumura, M., Shin, S., Usumoto, Y. & Ikeda, N., Mar 1 2019, In : Journal of Forensic Radiology and Imaging. 16, p. 57-64 8 p.

Research output: Contribution to journalArticle

Head
Tomography
Yaws

Association between peripheral blood markers and immune-related factors on tumor cells in patients with resected primary lung adenocarcinoma

Takada, K., Shimokawa, M., Tanaka, K., Kouhashi, K., Haro, A., Osoegawa, A., Tagawa, T., Azuma, K., Okamoto, I., Oda, Y. & Mori, M., Jun 1 2019, In : PloS one. 14, 6, e0217991.

Research output: Contribution to journalArticle

Open Access
Indoleamine-Pyrrole 2,3,-Dioxygenase
Immunologic Factors
adenocarcinoma
Cell death
Tumors
1 Citation (Scopus)

Association of Missense Polymorphism in HSD3B1 With Outcomes Among Men With Prostate Cancer Treated With Androgen-Deprivation Therapy or Abiraterone

shiota, M., Narita, S., Akamatsu, S., Fujimoto, N., Sumiyoshi, T., Fujiwara, M., Uchiumi, T., Habuchi, T., Ogawa, O. & Eto, M., Feb 1 2019, In : JAMA network open. 2, 2, p. e190115

Research output: Contribution to journalArticle

Open Access
Androgens
Prostatic Neoplasms
Odds Ratio
Therapeutics
Castration

BspR/BtrA, an Anti-σ Factor, Regulates the Ability of Bordetella bronchiseptica To Cause Cough in Rats

Nakamura, K., Shinoda, N., Hiramatsu, Y., Ohnishi, S., Kamitani, S., Ogura, Y., Hayashi, T. & Horiguchi, Y., Apr 24 2019, In : mSphere. 4, 2

Research output: Contribution to journalArticle

Open Access
Bordetella bronchiseptica
Cough
Bordetella pertussis
Bordetella Infections
Bordetella

Budding Uninhibited by Benzimidazole-1 Insufficiency Prevents Acute Renal Failure in Severe Sepsis by Maintaining Anticoagulant Functions of Vascular Endothelial Cells

Matsubara, Y., Matsumoto, T., Yoshiya, K., Yoshida, A., Ikeda, S., Furuyama, T., Nakatsu, Y., Tsuzuki, T., Nomura, M. & Maehara, Y., Mar 1 2019, In : Shock (Augusta, Ga.). 51, 3, p. 364-371 8 p.

Research output: Contribution to journalArticle

Acute Kidney Injury
Anticoagulants
Sepsis
Endothelial Cells
Thrombomodulin
Androgen Antagonists
Androgen Receptors
docetaxel
Prostatic Neoplasms
Smoking
2 Citations (Scopus)

Co-expression of IDO1 and PD-L1 in lung squamous cell carcinoma: Potential targets of novel combination therapy

Takada, K., Kouhashi, K., Shimokawa, M., Haro, A., Osoegawa, A., Tagawa, T., Seto, T., Oda, Y. & Maehara, Y., Feb 1 2019, In : Lung Cancer. 128, p. 26-32 7 p.

Research output: Contribution to journalArticle

CD274 Antigen
Indoleamine-Pyrrole 2,3,-Dioxygenase
Squamous Cell Carcinoma
Lung
Therapeutics

Consensus and variations in cell line specificity among human metapneumovirus strains

Nao, N., Sato, K., Yamagishi, J., Tahara, M., Nakatsu, Y., Seki, F., Katoh, H., Ohnuma, A., Shirogane, Y., Hayashi, M., Suzuki, T., Kikuta, H., Nishimura, H. & Takeda, M., Apr 1 2019, In : PloS one. 14, 4, e0215822.

Research output: Contribution to journalArticle

Open Access
Human metapneumovirus
Metapneumovirus
Cells
cell lines
Cell Line
Cuprizone
Phytoestrogens
Genistein
Demyelinating Diseases
Hippocampus

Dairy consumption and risk of functional disability in an elderly Japanese population: The Hisayama Study

Yoshida, D., Ohara, T., Hata, J., Shibata, M., Hirakawa, Y., Honda, T., Uchida, K., Takasugi, S., Kitazono, T., Kiyohara, Y. & Ninomiya, T., Jun 1 2019, In : American Journal of Clinical Nutrition. 109, 6, p. 1664-1671 8 p.

Research output: Contribution to journalArticle

Activities of Daily Living
Population
Independent Living
Geriatrics
Mental Competency

Diagnostic challenge of the newborn patients with heritable protein C deficiency

Ichiyama, M., Inoue, H., Ochiai, M., ishimura, M., Shiraishi, A., Fujiyoshi, J., Yamashita, H., Sato, K., Matsumoto, S., Hotta, T., Uchiumi, T., Kang, D. & Ohga, S., Feb 1 2019, In : Journal of Perinatology. 39, 2, p. 212-219 8 p.

Research output: Contribution to journalArticle

Protein C Deficiency
Protein C
Protein S
Newborn Infant
Mutation

Differential genomic destabilisation in human cells with pathogenic MSH2 mutations introduced by genome editing

Hayashida, G., Shioi, S., Hidaka, K., Fujikane, R., Hidaka, M., Tsurimoto, T., Tsuzuki, T., Oda, S. & Nakatsu, Y., Apr 15 2019, In : Experimental Cell Research. 377, 1-2, p. 24-35 12 p.

Research output: Contribution to journalArticle

Open Access
Microsatellite Instability
DNA Mismatch Repair
Mutation
Microsatellite Repeats
Hereditary Nonpolyposis Colorectal Neoplasms

Draft genome sequence of mycolicibacterium sp. strain ncctsukiji, isolated from blood culture of a patient with malignant lymphoma

Fukano, H., Yoshida, M., Shouji, M., Hatta, S., Maruyama, D., Izutsu, K., Shiotsuka, M., Ogura, Y., Hayashi, T., Hasegawa, N., Iwata, S. & Hoshino, Y., Jan 1 2019, In : Microbiology Resource Announcements. 8, 14, e01575-18.

Research output: Contribution to journalArticle

Open Access
Multilocus Sequence Typing
Lymphoma
Genome
Blood Culture

Elevated non-invasive liver fibrosis markers and risk of liver carcinoma in adult patients after repair of tetralogy of Fallot

Yamamura, K., Sakamoto, I., Morihana, E., Hirata, Y., Nagata, H., Yamasaki, Y., Okumura, Y., Kouhashi, K., Koto, K., Tsutsui, H. & Ohga, S., Jul 15 2019, In : International Journal of Cardiology. 287, p. 121-126 6 p.

Research output: Contribution to journalArticle

Tetralogy of Fallot
Liver Cirrhosis
Carcinoma
Liver
Hyaluronic Acid

Evaluation of SNP calling methods for closely related bacterial isolates and a novel high-accuracy pipeline: BactSNP

Yoshimura, D., Kajitani, R., Gotoh, Y., Katahira, K., Okuno, M., Ogura, Y., Hayashi, T. & Itoh, T., May 1 2019, In : Microbial Genomics. 5, 5

Research output: Contribution to journalArticle

Open Access
Single Nucleotide Polymorphism
Genome
Benchmarking
Disease Outbreaks
Bacteria
Type 1 Diabetes Mellitus
Hypoglycemia
Pancreatitis
C-Peptide
Pancreas
Gyrus Cinguli
Alzheimer Disease
Temporal Lobe
Brain
Frontal Lobe

Genome sequencing verifies relapsed infection of helicobacter cinaedi

Sawada, O., Gotoh, Y., Taniguchi, T., Furukawa, S., Yoshimura, D., Sasaki, S., Shida, H., Kusunoki, Y., Yamamura, T., Furuya, K., Itoh, T., Horita, T., Hayashi, T. & Misawa, N., Jan 1 2019, In : Open Forum Infectious Diseases. 6, 5

Research output: Contribution to journalArticle

Open Access
Helicobacter Infections
Genome
Infection
Single Nucleotide Polymorphism
Clone Cells

Glypican-3 expression in malignant small round cell tumors

Shibui, Y., Miyoshi, K., Kouhashi, K., Kinoshita, Y., Kuda, M., Yamamoto, H., Taguchi, T. & Oda, Y., Mar 1 2019, In : Oncology Letters. 17, 3, p. 3523-3528 6 p.

Research output: Contribution to journalArticle

Glypicans
Neoplasms
Neuroblastoma
Ewing's Sarcoma
Desmoplastic Small Round Cell Tumor
Neuroendocrine Tumors
Neuroblastoma
Pheochromocytoma
Neoplasms
Ewing's Sarcoma

Identification of genomic alterations acquired during treatment with EGFR-TKIs in non-small cell lung cancer

Kubo, N., Harada, T., Shiraishi, Y., Nosaki, K., Nakagaki, N., Takeshita, M., Ouchi, H., Iwama, E., Tanaka, K., Okamoto, I., Sasaki, H. & Nakanishi, Y., Feb 1 2019, In : Anticancer research. 39, 2, p. 671-677 7 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
Therapeutics
Exome
Open Access
Genetic Polymorphisms
Caffeine
Healthy Volunteers
Heart Rate
Blood Pressure
Japan
Smoking
Health
Occupational Groups
Smoke-Free Policy

Intrahepatic cholangiocarcinoma after the Fontan procedure

Shibui, Y., Kouhashi, K., Sakamoto, I., Yamamura, K. & Oda, Y., Mar 1 2019, In : Human Pathology: Case Reports. 15, p. 15-19 5 p.

Research output: Contribution to journalArticle

Fontan Procedure
Cholangiocarcinoma
Liver Cirrhosis
Heart Failure
Liver

Lipase/Oxovanadium Co-Catalyzed Dynamic Kinetic Resolution of Propargyl Alcohols: Competition between Racemization and Rearrangement

Kawanishi, S., Oki, S., Kundu, D. & Akai, S., May 3 2019, In : Organic Letters. 21, 9, p. 2978-2982 5 p.

Research output: Contribution to journalArticle

Lipase
alcohols
Magic
Kinetics
Enantiomers

Local structural changes of the influenza A virus ribonucleoprotein complex by single mutations in the specific residues involved in efficient genome packaging

Takizawa, N., Ogura, Y., Fujita, Y., Noda, T., Shigematsu, H., Hayashi, T. & Kurokawa, K., May 1 2019, In : Virology. 531, p. 126-140 15 p.

Research output: Contribution to journalArticle

Ribonucleoproteins
Influenza A virus
Product Packaging
Genome
Viruses
Exercise
Population
Independent Living
Japan
Light

Meteorological effects on severe hemoptysis: A hospital-based observational study

Ogata, H., Matsumoto, K., Shinozaki, S., Hasegawa, M., Nakamura, S., Mizusaki, S., Takao, T., Nakatomi, K., Nakashima, N., Takahashi, K., Soeda, H., Hanada, K. & Koto, H., Jan 1 2019, In : Respiratory Investigation.

Research output: Contribution to journalArticle

Hemoptysis
Observational Studies
Humidity
Meteorological Concepts
Logistic Models

Mirabegron induces relaxant effects via cAMP signaling-dependent and -independent pathways in detrusor smooth muscle

Maki, T., Kajioka, S., Itsumi, M., Kareman, E., Lee, K., shiota, M. & Eto, M., Apr 1 2019, In : LUTS: Lower Urinary Tract Symptoms. 11, 2, p. O209-O217

Research output: Contribution to journalArticle

Smooth Muscle
Swine
Carbachol
Escin
Adrenergic Receptors
1 Citation (Scopus)

Multi-step genomic dissection of a suspected intra-hospital helicobacter cinaedi outbreak

Gotoh, Y., Taniguchi, T., Yoshimura, D., Katsura, K., Saeki, Y., Hirabara, Y., Fukuda, M., Takajo, I., Tomida, J., Kawamura, Y., Ogura, Y., Itoh, T., Misawa, N., Okayama, A. & Hayashi, T., Jan 1 2019, In : Microbial Genomics. 5, 1, 000236.

Research output: Contribution to journalArticle

Helicobacter
Disease Outbreaks
Dissection
Genome
Bacteremia
1 Citation (Scopus)

Navigation surgery using indocyanine green fluorescent imaging for hepatoblastoma patients

Sozaki, R., Kawakubo, N., Matsuura, T., Yoshimaru, K., Koga, Y., Takemoto, J., Shibui, Y., Kouhashi, K., Hayashida, M., Oda, Y., Ohga, S. & Taguchi, T., May 1 2019, In : Pediatric surgery international. 35, 5, p. 551-557 7 p.

Research output: Contribution to journalArticle

Hepatoblastoma
Indocyanine Green
Neoplasms
Liver
Lung
Open Access
Diabetes Mellitus
Insulin Resistance
Population
Homeostasis
Energy Intake

Periodontitis Is Associated with Chronic Obstructive Pulmonary Disease

Takeuchi, K., Matsumoto, K., Furuta, M., Fukuyama, S., Takeshita, T., Ogata, H., Suma, S., Shibata, Y., Shimazaki, Y., Hata, J., Ninomiya, T., Nakanishi, Y., Inoue, H. & Yamashita, Y., May 1 2019, In : Journal of Dental Research. 98, 5, p. 534-540 7 p.

Research output: Contribution to journalArticle

Periodontitis
Chronic Obstructive Pulmonary Disease
Vital Capacity
Forced Expiratory Volume
Confidence Intervals

Phenotypic characterization and virulence-related properties of Escherichia albertii strains isolated from children with diarrhea in Brazil

Lima, M. P., Yamamoto, D., de Mello Santos, A. C., Ooka, T., Hernandes, R. T., Vieira, M. A. M., Santos, F. F., Silva, R. M., Hayashi, T. & Gomes, T. A. T., Mar 1 2019, In : Pathogens and disease. 77, 2

Research output: Contribution to journalArticle

Open Access
Escherichia
Brazil
Virulence
Diarrhea
Virulence Factors
2 Citations (Scopus)

Pioneer Factor NeuroD1 Rearranges Transcriptional and Epigenetic Profiles to Execute Microglia-Neuron Conversion

Matsuda, T., Irie, T., Katsurabayashi, S., Hayashi, Y., Nagai, T., Hamazaki, N., Adefuin, A. M. D., Miura, F., Ito, T., Kimura, H., Shirahige, K., Takeda, T., Iwasaki, K., Imamura, T. & Nakashima, K., Feb 6 2019, In : Neuron. 101, 3, p. 472-485.e7

Research output: Contribution to journalArticle

Microglia
Epigenomics
Neurons
Transcription Factors
Genes

Poor glycemic control and posterior circulation ischemic stroke

Fukuoka Stroke Registry Investigators, Apr 1 2019, In : Neurology: Clinical Practice. 9, 2, p. 129-139 11 p.

Research output: Contribution to journalArticle

Stroke
Propensity Score
Hemoglobins
Glucose
Insulin Resistance

Possibility of lung cancer risk in indium-exposed workers: An 11-year multicenter cohort study

Nakano, M., Omae, K., Tanaka, A. & Hirata, M., May 1 2019, In : Journal of Occupational Health. 61, 3, p. 251-256 6 p.

Research output: Contribution to journalArticle

Open Access
Indium
Multicenter Studies
Lung Neoplasms
Cohort Studies
Tomography

Prediction of liver fibrosis using CT under respiratory control: New attempt using deformation vectors obtained by non-rigid registration technique

Nishie, A., Akahori, S., Asayama, Y., Ishigami, K., ushijima, Y., Kakihara, D., Nakayama, T., Takayama, Y., Fujita, N., Morita, K., Ishimatsu, K., Takao, S., Yoshizumi, T., Kouhashi, K., Li, Y. & Honda, H., Mar 1 2019, In : Anticancer research. 39, 3, p. 1417-1424 8 p.

Research output: Contribution to journalArticle

Liver Cirrhosis
Fibrosis
Liver
ROC Curve
Area Under Curve

Predictive equation for post-mortem interval using spectrophotometric values of post-mortem lividity: A pilot study

Usumoto, Y., Kudo, K., Tsuji, A., Ihama, Y. & Ikeda, N., Apr 1 2019, In : Forensic Science International. 297, p. 47-55 9 p.

Research output: Contribution to journalArticle

Color
Skin Pigmentation
Skin
Femoral Vein
Cadaver

Predictive equation to estimate post-mortem interval using spectrophotometric blood-colour values

Usumoto, Y., Kudo, K., Tsuji, A., Ihama, Y. & Ikeda, N., Jan 1 2019, In : Medicine, Science and the Law. 59, 1, p. 36-41 6 p.

Research output: Contribution to journalArticle

Color
Values
Thigh
Cadaver
Autopsy

Predictors of recurrence and postoperative outcomes in patients with non-skull base meningiomas based on modern neurosurgical standards

Michiwaki, Y., Hata, N., Amano, T., Suzuki, S. O., Akagi, Y., Kuga, D., Onozuka, D., Momosaki, S., Nakamizo, A., Yoshimoto, K., Iwaki, T. & Iihara, K., Mar 1 2019, In : Interdisciplinary Neurosurgery: Advanced Techniques and Case Management. 15, p. 30-37 8 p.

Research output: Contribution to journalArticle

Meningioma
Recurrence
Survival
Neoplasms
Multivariate Analysis

Prevalence of adult epilepsy in a general Japanese population: The Hisayama study

Tanaka, A., Hata, J., Akamatsu, N., Mukai, N., Hirakawa, Y., Yoshida, D., Kishimoto, H., Ohara, T., Mizuno, T., Tsuji, S., Kitazono, T. & Ninomiya, T., Mar 1 2019, In : Epilepsia Open. 4, 1, p. 182-186 5 p.

Research output: Contribution to journalArticle

Open Access
Epilepsy
Population
Cerebrovascular Disorders
Confidence Intervals
Tonic-Clonic Epilepsy
1 Citation (Scopus)

Prognostic Impact of Programmed Death-Ligand 2 Expression in Primary Lung Adenocarcinoma Patients

Takamori, S., Takada, K., Azuma, K., Jogo, T., Shimokawa, M., Toyokawa, G., Hirai, F., Tagawa, T., Kawahara, A., Akiba, J., Okamoto, I., Nakanishi, Y., Oda, Y., Hoshino, T. & Maehara, Y., Jun 15 2019, In : Annals of Surgical Oncology. 26, 6, p. 1916-1924 9 p.

Research output: Contribution to journalArticle

Ligands
Adenocarcinoma of lung
Immunotherapy
Disease-Free Survival
Survival