Department of Basic Medicine

Research Output 1980 2019

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2019

2,5-Dimethylcelecoxib prevents isoprenaline-induced cardiomyocyte hypertrophy and cardiac fibroblast activation by inhibiting Akt-mediated GSK-3 phosphorylation

Morishige, S., Takahashi-Yanaga, F., Ishikane, S., arioka, M., Igawa, K., Kuroo, A., Tomooka, K., Shiose, A. & Sasaguri, T., Oct 1 2019, In : Biochemical Pharmacology. 168, p. 82-90 9 p.

Research output: Contribution to journalArticle

Glycogen Synthase Kinase 3
Phosphorylation
Cardiomegaly
Fibroblasts
Isoproterenol

A case of autonomous cortisol secretion in a patient with subclinical Cushing's syndrome, GNAS mutation, and paradoxical cortisol response to dexamethasone

Sakaguchi, C., Ashida, K., Kouhashi, K., Ohe, K., Fujii, Y., Yano, S., matsuda, Y., Sakamoto, S., Sakamoto, R., Oda, Y., Nomura, M. & Ogawa, Y., Jan 22 2019, In : BMC Endocrine Disorders. 19, 1, 13.

Research output: Contribution to journalArticle

Cushing Syndrome
Dexamethasone
Hydrocortisone
Mutation
Oral Administration

aCGH Analysis of Predictive Biomarkers for Response to Bevacizumab plus Oxaliplatin- or Irinotecan-Based Chemotherapy in Patients with Metastatic Colorectal Cancer

Fujita, Y., Taguri, M., Yamazaki, K., Tsurutani, J., Sakai, K., Tsushima, T., Nagase, M., Tamagawa, H., Ueda, S., Tamura, T., Tsuji, Y., Murata, K., Taira, K., Denda, T., Moriwaki, T., Funai, S., Nakajima, T. E., Muro, K., Tsuji, A., Yoshida, M. & 11 others, Suyama, K., Kurimoto, T., Sugimoto, N., Baba, E., Seki, N., Sato, M., Shimura, T., Boku, N., Hyodo, I., Yamanaka, T. & Nishio, K., Mar 1 2019, In : Oncologist. 24, 3, p. 327-337 11 p.

Research output: Contribution to journalArticle

irinotecan
oxaliplatin
Comparative Genomic Hybridization
Colorectal Neoplasms
Biomarkers
4 Citations (Scopus)

A Clinicopathological and Prognostic Analysis of PD-L2 Expression in Surgically Resected Primary Lung Squamous Cell Carcinoma

Matsubara, T., Takada, K., Azuma, K., Takamori, S., Toyokawa, G., Haro, A., Osoegawa, A., Tagawa, T., Kawahara, A., Akiba, J., Okamoto, I., Nakanishi, Y., Oda, Y., Hoshino, T. & Maehara, Y., Jun 15 2019, In : Annals of Surgical Oncology. 26, 6, p. 1925-1933 9 p.

Research output: Contribution to journalArticle

Squamous Cell Carcinoma
Ligands
Lung
CD274 Antigen
Immunotherapy

A highly efficient method for concentrating DNA from river water by combined coagulation and foam separation

Suzuki, Y., Imafuku, Y., Nishiyama, M., Teranishi, K., Jikumaru, A., Nukazawa, K. & Ogura, Y., Jan 1 2019, (Accepted/In press) In : Separation Science and Technology (Philadelphia). 54, 18, p. 3128-3134 7 p.

Research output: Contribution to journalArticle

Coagulation
Foams
DNA
Rivers
Water
1 Citation (Scopus)

Alternative oxidase capacity of mitochondria in microsporophylls may function in cycad thermogenesis

Inaba, Y. I., Sato, M., Sato, M. P., Kurayama, Y., Yamamoto, H., Ohata, M., Ogura, Y., Hayashi, T., Toyooka, K. & Inaba, T., Jun 1 2019, In : Plant physiology. 180, 2, p. 743-756 14 p.

Research output: Contribution to journalArticle

Open Access
Cycadopsida
seed cones
Thermogenesis
heat production
Mitochondria

Analysis of response evaluation criteria in solid tumors reduction ratio of primary chemotherapy in unresectable advanced or recurrent colorectal cancer

Kawagoe, S., Nakano, M., Uchino, K., Arimizu, K., Kajitani, T., Shimokawa, H., Kusumoto, T., Ikejiri, K. & Baba, E., Sep 1 2019, In : Molecular and Clinical Oncology. 11, 3, p. 243-251 9 p.

Research output: Contribution to journalArticle

Open Access
Colorectal Neoplasms
Drug Therapy
Neoplasm Metastasis
Liver
Survival

Analysis of systemic lupus erythematosus-related interstitial pneumonia: a retrospective multicentre study

Enomoto, N., Egashira, R., Tabata, K., Hashisako, M., Kitani, M., Waseda, Y., Ishizuka, T., Watanabe, S., Kasahara, K., Izumi, S., Shiraki, A., Miyamoto, A., Kishi, K., Kishaba, T., Sugimoto, C., Inoue, Y., Kataoka, K., Kondoh, Y., Tsuchiya, Y., Baba, T. & 4 others, Sugiura, H., Tanaka, T., Sumikawa, H. & Suda, T., Dec 1 2019, In : Scientific reports. 9, 1, 7355.

Research output: Contribution to journalArticle

Open Access
Interstitial Lung Diseases
Systemic Lupus Erythematosus
Multicenter Studies
Retrospective Studies
Tomography

Arsenate and microbial dynamics in different phosphorus regimes of the subtropical Pacific Ocean

Hashihama, F., Suwa, S., Kanda, J., Ehama, M., Sakuraba, R., Kinouchi, S., Sato, M., Yamaguchi, T., Saito, H., Ogura, Y., Hayashi, T., Mori, H., Kurokawa, K., Suzuki, S. & Hamasaki, K., Sep 1 2019, In : Progress in Oceanography. 176, 102115.

Research output: Contribution to journalArticle

arsenates
arsenate
Pacific Ocean
phosphate
phosphates

A simple method for semi-automatic readjustment for positioning in post-mortem head computed tomography imaging

Kawazoe, Y., Morishita, J., Matsunobu, Y., Okumura, M., Shin, S., Usumoto, Y. & Ikeda, N., Mar 1 2019, In : Journal of Forensic Radiology and Imaging. 16, p. 57-64 8 p.

Research output: Contribution to journalArticle

Head
Tomography
Yaws
Open Access
Propensity Score
Cohort Studies
Odds Ratio
Confidence Intervals
Physicians

Association between peripheral blood markers and immune-related factors on tumor cells in patients with resected primary lung adenocarcinoma

Takada, K., Shimokawa, M., Tanaka, K., Kouhashi, K., Haro, A., Osoegawa, A., Tagawa, T., Azuma, K., Okamoto, I., Oda, Y. & Mori, M., Jun 1 2019, In : PloS one. 14, 6, e0217991.

Research output: Contribution to journalArticle

Open Access
Indoleamine-Pyrrole 2,3,-Dioxygenase
Immunologic Factors
adenocarcinoma
Cell death
Tumors

Association between Serum β-Alanine and Risk of Dementia

Hata, J., Ohara, T., Katakura, Y., Shimizu, K., Yamashita, S., Yoshida, D., Honda, T., Hirakawa, Y., Shibata, M., Sakata, S., Kitazono, T., Kuhara, S. & Ninomiya, T., Sep 1 2019, In : American journal of epidemiology. 188, 9, p. 1637-1645 9 p.

Research output: Contribution to journalArticle

Alanine
Dementia
Anserine
Carnosine
Confidence Intervals
2 Citations (Scopus)

Association of Missense Polymorphism in HSD3B1 With Outcomes Among Men With Prostate Cancer Treated With Androgen-Deprivation Therapy or Abiraterone

shiota, M., Narita, S., Akamatsu, S., Fujimoto, N., Sumiyoshi, T., Fujiwara, M., Uchiumi, T., Habuchi, T., Ogawa, O. & Eto, M., Feb 1 2019, In : JAMA network open. 2, 2, p. e190115

Research output: Contribution to journalArticle

Open Access
Androgens
Prostatic Neoplasms
Odds Ratio
Therapeutics
Castration

Base-Resolution Methylome of Retinal Pigment Epithelial Cells Used in the First Trial of Human Induced Pluripotent Stem Cell-Based Autologous Transplantation

Araki, H., Miura, F., Watanabe, A., Morinaga, C., Kitaoka, F., Kitano, Y., Sakai, N., Shibata, Y., Terada, M., Goto, S., Yamanaka, S., Takahashi, M. & Ito, T., Oct 8 2019, In : Stem Cell Reports. 13, 4, p. 761-774 14 p.

Research output: Contribution to journalArticle

Open Access
Induced Pluripotent Stem Cells
Retinal Pigments
Autologous Transplantation
Macular Degeneration
DNA Methylation

BspR/BtrA, an Anti-σ Factor, Regulates the Ability of Bordetella bronchiseptica To Cause Cough in Rats

Nakamura, K., Shinoda, N., Hiramatsu, Y., Ohnishi, S., Kamitani, S., Ogura, Y., Hayashi, T. & Horiguchi, Y., Apr 24 2019, In : mSphere. 4, 2

Research output: Contribution to journalArticle

Open Access
Bordetella bronchiseptica
Cough
Bordetella pertussis
Bordetella Infections
Bordetella
2 Citations (Scopus)

Budding Uninhibited by Benzimidazole-1 Insufficiency Prevents Acute Renal Failure in Severe Sepsis by Maintaining Anticoagulant Functions of Vascular Endothelial Cells

Matsubara, Y., Matsumoto, T., Yoshiya, K., Yoshida, A., Ikeda, S., Furuyama, T., Nakatsu, Y., Tsuzuki, T., Nomura, M. & Maehara, Y., Mar 1 2019, In : Shock. 51, 3, p. 364-371 8 p.

Research output: Contribution to journalArticle

Acute Kidney Injury
Anticoagulants
Sepsis
Endothelial Cells
Thrombomodulin
1 Citation (Scopus)
Androgen Antagonists
Androgen Receptors
docetaxel
Prostatic Neoplasms
Smoking
1 Citation (Scopus)

Clinical and computed tomography characteristics of non-small cell lung cancer with ALK gene rearrangement: Comparison with EGFR mutation and ALK/EGFR-negative lung cancer

Mori, M., Hayashi, H., Fukuda, M., Honda, S., Kitazaki, T., Shigematsu, K., Matsuyama, N., Otsubo, M., Nagayasu, T., Hashisako, M., Tabata, K., Uetani, M. & Ashizawa, K., Apr 2019, In : Thoracic Cancer. 10, 4, p. 872-879 8 p.

Research output: Contribution to journalArticle

Open Access
Gene Rearrangement
Non-Small Cell Lung Carcinoma
Lung Neoplasms
Tomography
Mutation
4 Citations (Scopus)

Co-expression of IDO1 and PD-L1 in lung squamous cell carcinoma: Potential targets of novel combination therapy

Takada, K., Kouhashi, K., Shimokawa, M., Haro, A., Osoegawa, A., Tagawa, T., Seto, T., Oda, Y. & Maehara, Y., Feb 1 2019, In : Lung Cancer. 128, p. 26-32 7 p.

Research output: Contribution to journalArticle

CD274 Antigen
Indoleamine-Pyrrole 2,3,-Dioxygenase
Squamous Cell Carcinoma
Lung
Therapeutics
1 Citation (Scopus)

Consensus and variations in cell line specificity among human metapneumovirus strains

Nao, N., Sato, K., Yamagishi, J., Tahara, M., Nakatsu, Y., Seki, F., Katoh, H., Ohnuma, A., Shirogane, Y., Hayashi, M., Suzuki, T., Kikuta, H., Nishimura, H. & Takeda, M., Apr 1 2019, In : PloS one. 14, 4, e0215822.

Research output: Contribution to journalArticle

Open Access
Human metapneumovirus
Metapneumovirus
Cells
cell lines
Cell Line

Contractile elements and their sympathetic regulations in the pig urinary bladder: a species and regional comparative study

Mitsui, R., Lee, K., Uchiyama, A., Hayakawa, S., Kinoshita, F., Kajioka, S., Eto, M. & Hashitani, H., Jan 1 2019, (Accepted/In press) In : Cell and tissue research.

Research output: Contribution to journalArticle

Mucous Membrane
Urinary Bladder
Swine
Smooth Muscle
Tyrosine 3-Monooxygenase
1 Citation (Scopus)
Cuprizone
Phytoestrogens
Genistein
Demyelinating Diseases
Hippocampus

Dairy consumption and risk of functional disability in an elderly Japanese population: The Hisayama Study

Yoshida, D., Ohara, T., Hata, J., Shibata, M., Hirakawa, Y., Honda, T., Uchida, K., Takasugi, S., Kitazono, T., Kiyohara, Y. & Ninomiya, T., Jun 1 2019, In : American Journal of Clinical Nutrition. 109, 6, p. 1664-1671 8 p.

Research output: Contribution to journalArticle

Activities of Daily Living
Population
Independent Living
Geriatrics
Mental Competency
1 Citation (Scopus)

Diagnostic challenge of the newborn patients with heritable protein C deficiency

Ichiyama, M., Inoue, H., Ochiai, M., ishimura, M., Shiraishi, A., Fujiyoshi, J., Yamashita, H., Sato, K., Matsumoto, S., Hotta, T., Uchiumi, T., Kang, D. & Ohga, S., Feb 1 2019, In : Journal of Perinatology. 39, 2, p. 212-219 8 p.

Research output: Contribution to journalArticle

Protein C Deficiency
Protein C
Protein S
Newborn Infant
Mutation

Differential genomic destabilisation in human cells with pathogenic MSH2 mutations introduced by genome editing

Hayashida, G., Shioi, S., Hidaka, K., Fujikane, R., Hidaka, M., Tsurimoto, T., Tsuzuki, T., Oda, S. & Nakatsu, Y., Apr 15 2019, In : Experimental Cell Research. 377, 1-2, p. 24-35 12 p.

Research output: Contribution to journalArticle

Open Access
Microsatellite Instability
DNA Mismatch Repair
Mutation
Microsatellite Repeats
Hereditary Nonpolyposis Colorectal Neoplasms

Draft genome sequence of mycolicibacterium sp. strain ncctsukiji, isolated from blood culture of a patient with malignant lymphoma

Fukano, H., Yoshida, M., Shouji, M., Hatta, S., Maruyama, D., Izutsu, K., Shiotsuka, M., Ogura, Y., Hayashi, T., Hasegawa, N., Iwata, S. & Hoshino, Y., Jan 1 2019, In : Microbiology Resource Announcements. 8, 14, e01575-18.

Research output: Contribution to journalArticle

Open Access
Multilocus Sequence Typing
Lymphoma
Genome
Blood Culture

Efficacy and safety of ramucirumab plus modified FOLFIRI for metastatic colorectal cancer

Yoshihiro, T., Kusaba, H., Makiyama, A., Kobayashi, K., Uenomachi, M., Ito, M., Doi, Y., Mitsugi, K., Aikawa, T., Takayoshi, K., Esaki, T., Shimokawa, H., Tsuchihashi, K., ariyama, H., Akashi, K. & Baba, E., May 15 2019, In : International Journal of Clinical Oncology. 24, 5, p. 508-515 8 p.

Research output: Contribution to journalArticle

Colorectal Neoplasms
Safety
irinotecan
Confidence Intervals
ramucirumab

Elevated non-invasive liver fibrosis markers and risk of liver carcinoma in adult patients after repair of tetralogy of Fallot

Yamamura, K., Sakamoto, I., Morihana, E., Hirata, Y., Nagata, H., Yamasaki, Y., Okumura, Y., Kouhashi, K., Koto, K., Tsutsui, H. & Ohga, S., Jul 15 2019, In : International Journal of Cardiology. 287, p. 121-126 6 p.

Research output: Contribution to journalArticle

Tetralogy of Fallot
Liver Cirrhosis
Carcinoma
Liver
Hyaluronic Acid

Endocardium differentiation through Sox17 expression in endocardium precursor cells regulates heart development in mice

Saba, R., Kitajima, K., Rainbow, L., Engert, S., Uemura, M., Ishida, H., Kokkinopoulos, I., Shintani, Y., Miyagawa, S., Kanai, Y., Kanai-Azuma, M., Koopman, P., Meno, C., Kenny, J., Lickert, H., Saga, Y., Suzuki, K., Sawa, Y. & Yashiro, K., Dec 1 2019, In : Scientific reports. 9, 1, 11953.

Research output: Contribution to journalArticle

Open Access
Endocardium
Myocardium
Stem Cells
Embryonic Structures
Mesoderm

Ep 4 receptor-associated protein regulates gluconeogenesis in the liver and is associated with hyperglycemia in diabetic mice

Higuchi, S., Fujikawa, R., Nakatsuji, M., Yasui, M., Ikedo, T., Nagata, M., Mishima, K., Irie, K., Matsumoto, M., Yokode, M. & Minami, M., Mar 1 2019, In : American Journal of Physiology - Endocrinology and Metabolism. 316, 3, p. E410-E417

Research output: Contribution to journalArticle

Gluconeogenesis
Hyperglycemia
Liver
Hepatocytes
Proteins
1 Citation (Scopus)

Evaluation of SNP calling methods for closely related bacterial isolates and a novel high-accuracy pipeline: BactSNP

Yoshimura, D., Kajitani, R., Gotoh, Y., Katahira, K., Okuno, M., Ogura, Y., Hayashi, T. & Itoh, T., May 1 2019, In : Microbial Genomics. 5, 5

Research output: Contribution to journalArticle

Open Access
Single Nucleotide Polymorphism
Genome
Benchmarking
Disease Outbreaks
Bacteria

Extracellular calcium stimulates osteogenic differentiation of human adipose-derived stem cells by enhancing bone morphogenetic protein-2 expression

Yanai, R., Tetsuo, F., Ito, S., Itsumi, M., Yoshizumi, J., Maki, T., Mori, Y., Kubota, Y. & Kajioka, S., Nov 1 2019, In : Cell Calcium. 83, 102058.

Research output: Contribution to journalArticle

Bone Morphogenetic Protein 2
Stem Cells
Calcium
Calcium-Sensing Receptors
Messenger RNA

Fetal Membrane Inflammation Induces Preterm Birth Via Toll-Like Receptor 2 in Mice With Chronic Gingivitis

Konishi, H., Urabe, S., Miyoshi, H., Teraoka, Y., Maki, T., Furusho, H., Miyauchi, M., Takata, T., Kudo, Y. & Kajioka, S., Jul 1 2019, In : Reproductive Sciences. 26, 7, p. 869-878 10 p.

Research output: Contribution to journalArticle

Extraembryonic Membranes
Gingivitis
Premature Birth
Toll-Like Receptor 2
Inflammation

Frequent Detection of Pituitary-Derived PrPres in Human Prion Diseases

Honda, H., Matsumoto, M., Shijo, M., Hamasaki, H., Sadashima, S., Suzuki, S. O., Aishima, S., Kai, K., Nakayama, K. I., Sasagasako, N. & Iwaki, T., Oct 1 2019, In : Journal of neuropathology and experimental neurology. 78, 10, p. 922-929 8 p.

Research output: Contribution to journalArticle

Prion Diseases
Pituitary Gland
Growth Hormone
Human Growth Hormone
Gerstmann-Straussler-Scheinker Disease
Type 1 Diabetes Mellitus
Hypoglycemia
Pancreatitis
C-Peptide
Pancreas
Gyrus Cinguli
Alzheimer Disease
Temporal Lobe
Brain
Frontal Lobe

Genome sequencing verifies relapsed infection of helicobacter cinaedi

Sawada, O., Gotoh, Y., Taniguchi, T., Furukawa, S., Yoshimura, D., Sasaki, S., Shida, H., Kusunoki, Y., Yamamura, T., Furuya, K., Itoh, T., Horita, T., Hayashi, T. & Misawa, N., Jan 1 2019, In : Open Forum Infectious Diseases. 6, 5

Research output: Contribution to journalArticle

Open Access
Helicobacter Infections
Genome
Infection
Single Nucleotide Polymorphism
Clone Cells

Glypican-3 expression in malignant small round cell tumors

Shibui, Y., Miyoshi, K., Kouhashi, K., Kinoshita, Y., Kuda, M., Yamamoto, H., Taguchi, T. & Oda, Y., Mar 1 2019, In : Oncology Letters. 17, 3, p. 3523-3528 6 p.

Research output: Contribution to journalArticle

Glypicans
Neoplasms
Neuroblastoma
Ewing's Sarcoma
Desmoplastic Small Round Cell Tumor

Health Inequalities Among Elderly Type 2 Diabetes Mellitus Patients in Japan

Jiang, P., Babazono, A. & Fujita, T., Oct 29 2019, In : Population Health Management.

Research output: Contribution to journalArticle

Type 2 Diabetes Mellitus
Japan
Hospitalization
Social Class
Medication Adherence

Heat shock protein 105 peptide vaccine could induce antitumor immune reactions in a phase I clinical trial

Shimizu, Y., Yoshikawa, T., Kojima, T., Shoda, K., Nosaka, K., Mizuno, S., Wada, S., Fujimoto, Y., Sasada, T., Kohashi, K., Bando, H., Endo, I. & Nakatsura, T., Oct 1 2019, In : Cancer Science. 110, 10, p. 3049-3060 12 p.

Research output: Contribution to journalArticle

Open Access
Clinical Trials, Phase I
Subunit Vaccines
Heat-Shock Proteins
HLA-A24 Antigen
Esophageal Neoplasms
Open Access
Single-Stranded DNA
Ligation
Genome
Libraries
DNA Nucleotidylexotransferase
Neuroendocrine Tumors
Neuroblastoma
Pheochromocytoma
Neoplasms
Ewing's Sarcoma

Hypoalbuminemia for the prediction of venous thromboembolism and treatment of direct oral anticoagulants in metastatic gastric cancer patients

Takayoshi, K., Kusaba, H., Aikawa, T., Koreishi, S., Sagara, K., Nakano, M., Komoda, M., Kono, M., Fukata, M., Arita, T., Esaki, T., Akashi, K. & Baba, E., Sep 5 2019, In : Gastric Cancer. 22, 5, p. 988-998 11 p.

Research output: Contribution to journalArticle

Hypoalbuminemia
Venous Thromboembolism
Anticoagulants
Stomach Neoplasms
Therapeutics

Identification of genomic alterations acquired during treatment with EGFR-TKIs in non-small cell lung cancer

Kubo, N., Harada, T., Shiraishi, Y., Nosaki, K., Nakagaki, N., Takeshita, M., Ouchi, H., Iwama, E., Tanaka, K., Okamoto, I., Sasaki, H. & Nakanishi, Y., Feb 1 2019, In : Anticancer research. 39, 2, p. 671-677 7 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
Therapeutics
Exome
Open Access
Genetic Polymorphisms
Caffeine
Healthy Volunteers
Heart Rate
Blood Pressure
Japan
Smoking
Health
Occupational Groups
Smoke-Free Policy

Intrahepatic cholangiocarcinoma after the Fontan procedure

Shibui, Y., Kouhashi, K., Sakamoto, I., Yamamura, K. & Oda, Y., Mar 1 2019, In : Human Pathology: Case Reports. 15, p. 15-19 5 p.

Research output: Contribution to journalArticle

Fontan Procedure
Cholangiocarcinoma
Liver Cirrhosis
Heart Failure
Liver

Large-scale genome analysis of bovine commensal Escherichia coli reveals that bovine-adapted E. Coli lineages are serving as evolutionary sources of the emergence of human intestinal pathogenic strains

Arimizu, Y., Kirino, Y., Sato, M. P., Uno, K., Sato, T., Gotoh, Y., Auvray, F., Brugere, H., Oswald, E., Mainil, J. G., Anklam, K. S., Döpfer, D., Yoshino, S., Ooka, T., Tanizawa, Y., Nakamura, Y., Iguchi, A., Morita-Ishihara, T., Ohnishi, M., Akashi, K. & 2 others, Hayashi, T. & Ogura, Y., Jan 1 2019, In : Genome Research. 29, 9, p. 1495-1505 11 p.

Research output: Contribution to journalArticle

Open Access
Enteropathogenic Escherichia coli
Genome
Escherichia coli
Virulence
Enterocytes

Lipase/Oxovanadium Co-Catalyzed Dynamic Kinetic Resolution of Propargyl Alcohols: Competition between Racemization and Rearrangement

Kawanishi, S., Oki, S., Kundu, D. & Akai, S., May 3 2019, In : Organic Letters. 21, 9, p. 2978-2982 5 p.

Research output: Contribution to journalArticle

Lipase
alcohols
Magic
Kinetics
Enantiomers