Department of Immunobiology and Neuroscience

Research Output 1982 2019

2019
Islands of Calleja
Neurogenesis
Dentate Gyrus
Phenotype
Lateral Ventricles
Heavy Ion Radiotherapy
Sarcoma
Spine
Spinal Cord Compression
Compression Fractures

Diabetes Mellitus, A risk factor for Alzheimer's Disease

Nakabeppu, Y. (ed.) & Ninomiya, T. (ed.), May 7 2019, Singapore: Springer. 248 p. (Advances in Experimental Medicine and Biology)

Research output: Book/ReportBook

Diabetes Mellitus
Alzheimer Disease
Insulin
Glucose
Vascular Dementia

Dmrt factors determine the positional information of cerebral cortical progenitors via differential suppression of homeobox genes

Konno, D., Kishida, C., Maehara, K., Ohkawa, Y., Kiyonari, H., Okada, S. & Matsuzaki, F., Aug 2019, In : Development (Cambridge). 146, 15, dev174243.

Research output: Contribution to journalArticle

Open Access
Telencephalon
Homeobox Genes
Gene Dosage
Olfactory Bulb
Neurogenesis

Germline mutation: De novo mutation in reproductive lineage cells

Sakumi, K., Jan 1 2019, In : Genes and Genetic Systems. 94, 1, p. 3-12 10 p.

Research output: Contribution to journalArticle

Open Access
Germ-Line Mutation
Mutation Rate
Genome
Mutation
Cell Division
1 Citation (Scopus)

Macrophage centripetal migration drives spontaneous healing process after spinal cord injury

Kobayakawa, K., Ohkawa, Y., Yoshizaki, S., Tamaru, T., Saito, T., Kijima, K., Yokota, K., Hara, M., Kubota, K., Matsumoto, Y., Harimaya, K., Ozato, K., Masuda, T., Tsuda, M., Tamura, T., Inoue, K., Reggie Edgerton, V., Iwamoto, Y., Nakashima, Y. & Okada, S., May 15 2019, In : Science Advances. 5, 5, eaav5086.

Research output: Contribution to journalArticle

Open Access
spinal cord injuries
macrophages
healing
interferon
lesions

Molecular pathophysiology of insulin depletion, mitochondrial dysfunction, and oxidative stress in Alzheimer’s disease brain

Nakabeppu, Y., Jan 1 2019, Advances in Experimental Medicine and Biology. Springer New York LLC, p. 27-44 18 p. (Advances in Experimental Medicine and Biology; vol. 1128).

Research output: Chapter in Book/Report/Conference proceedingChapter

Oxidative stress
Brain
Alzheimer Disease
Oxidative Stress
Medical problems
1 Citation (Scopus)

Origins of brain insulin and its function

Nakabeppu, Y., Jan 1 2019, Advances in Experimental Medicine and Biology. Springer New York LLC, p. 1-11 11 p. (Advances in Experimental Medicine and Biology; vol. 1128).

Research output: Chapter in Book/Report/Conference proceedingChapter

Brain
Insulin
Neurology
Glucose
Central Nervous System

Oxidative stress induces different tissue dependent effects on Mutyh-deficient mice

Chen, J., Huang, Z., Wu, X., Kang, J., Ren, Y., Gao, W., Lu, X., Wang, J., Ding, W., Nakabeppu, Y., Fan, Y. & Wang, Y., Nov 1 2019, In : Free Radical Biology and Medicine. 143, p. 482-493 12 p.

Research output: Contribution to journalArticle

Oxidative stress
Galactose
Oxidative Stress
Tissue
Liver
2 Citations (Scopus)

Pathological changes of distal motor neurons after complete spinal cord injury

Yokota, K., Kubota, K., Kobayakawa, K., Saito, T., Hara, M., Kijima, K., Maeda, T., Katoh, H., Ohkawa, Y., Nakashima, Y. & Okada, S., Jan 9 2019, In : Molecular Brain. 12, 1, 4.

Research output: Contribution to journalArticle

Motor Neurons
Spinal Cord Injuries
Spinal Cord
Microdissection
Thoracic Injuries
Heavy Ion Radiotherapy
Spontaneous Fractures
Single-Photon Emission-Computed Tomography
Bone and Bones
Bone Remodeling
Arm Injuries
Ossification of Posterior Longitudinal Ligament
Pectoralis Muscles
Prone Position
Brachial Plexus

S100A4 Protein Is Essential for the Development of Mature Microfold Cells in Peyer's Patches

Kunimura, K., Sakata, D., Tun, X., Uruno, T., Ushijima, M., Katakai, T., Shiraishi, A., Aihara, R., Kamikaseda, Y., Matsubara, K., Kanegane, H., Sawa, S., Eberl, G., Ohga, S., Yoshikai, Y. & Fukui, Y., Nov 26 2019, In : Cell Reports. 29, 9, p. 2823-2834.e7

Research output: Contribution to journalArticle

Open Access
Peyer's Patches
Cytokine Receptors
Domes
Muramidase
Cells

Selective role of neurokinin B in IL-31–induced itch response in mice

Sakata, D., Uruno, T., Matsubara, K., Andoh, T., Yamamura, K., Magoshi, Y., Kunimura, K., Kamikaseda, Y., Furue, M. & Fukui, Y., Oct 1 2019, In : Journal of Allergy and Clinical Immunology. 144, 4, p. 1130-1133.e8

Research output: Contribution to journalArticle

Open Access
Neurokinin B

The acute phase serum zinc concentration is a reliable biomarker for predicting the functional outcome after spinal cord injury

Kijima, K., Kubota, K., Hara, M., Kobayakawa, K., Yokota, K., Saito, T., Yoshizaki, S., Maeda, T., Konno, D., Matsumoto, Y., Nakashima, Y. & Okada, S., Mar 2019, In : EBioMedicine. 41, p. 659-669 11 p.

Research output: Contribution to journalArticle

Open Access
Biomarkers
Spinal Cord Injuries
Zinc
Serum
Patient treatment

The beneficial aspects of spasticity in relation to ambulatory ability in mice with spinal cord injury

Yoshizaki, S., Yokota, K., Kubota, K., Saito, T., Tanaka, M., Konno, D. J., Maeda, T., Matsumoto, Y., Nakashima, Y. & Okada, S., Jan 1 2019, (Accepted/In press) In : Spinal Cord.

Research output: Contribution to journalArticle

Aptitude
Spinal Cord Injuries
Baclofen
Spasm
Walking

Tranexamic acid reduces heme cytotoxicity via the TLR4/TNF axis and ameliorates functional recovery after spinal cord injury

Yoshizaki, S., Kijima, K., Hara, M., Saito, T., Tamaru, T., Tanaka, M., Konno, D. J., Nakashima, Y. & Okada, S., Jul 29 2019, In : Journal of neuroinflammation. 16, 1, 160.

Research output: Contribution to journalArticle

Open Access
Tranexamic Acid
Toll-Like Receptor 4
Heme
Spinal Cord Injuries
Tumor Necrosis Factor-alpha
2018
2 Citations (Scopus)

An intronic single nucleotide polymorphism in the MUTYH gene is associated with increased risk for HCV-induced hepatocellular carcinoma

Sakurada, A., Miyanishi, K., Tanaka, S., Sato, M., Sakamoto, H., Kawano, Y., Takada, K., Nakabeppu, Y., Kobune, M. & Kato, J., Dec 1 2018, In : Free Radical Biology and Medicine. 129, p. 88-96 9 p.

Research output: Contribution to journalArticle

Polymorphism
Single Nucleotide Polymorphism
Hepatocellular Carcinoma
Nucleotides
Genes
2 Citations (Scopus)

A Novel Autoantibody against Plexin D1 in Patients with Neuropathic Pain

Fujii, T., Yamasaki, R., Iinuma, K., Tsuchimoto, D., Hayashi, Y., Saitoh, B. Y., Matsushita, T., Kido, M. A., Aishima, S., Nakanishi, H., Nakabeppu, Y. & Kira, J. I., Aug 2018, In : Annals of Neurology. 84, 2, p. 208-224 17 p.

Research output: Contribution to journalArticle

Neuralgia
Autoantibodies
Spinal Ganglia
Neurons
Unmyelinated Nerve Fibers
10 Citations (Scopus)

Association of adipocyte enhancer-binding protein 1 with Alzheimer's disease pathology in human hippocampi

Shijo, M., Honda, H., Suzuki, S. O., Hamasaki, H., Hokama, M., Abolhassani, N., Nakabeppu, Y., Ninomiya, T., Kitazono, T. & Iwaki, T., Jan 2018, In : Brain Pathology. 28, 1, p. 58-71 14 p.

Research output: Contribution to journalArticle

Adipocytes
Hippocampus
Carrier Proteins
Pathology
Alzheimer Disease

Cholesterol sulfate is a DOCK2 inhibitor that mediates tissue-specific immune evasion in the eye

Sakurai, T., Uruno, T., Tatsuguchi, T., Yamamura, K., Ushijima, M., Hattori, Y., Kukimoto-Niino, M., Mishima-Tsumagari, C., Watanabe, M., Suematsu, M. & Fukui, Y., Jul 31 2018, In : Science Signaling. 11, 541

Research output: Contribution to journalArticle

Immune Evasion
Cytokinesis
Tissue
Guanine Nucleotide Exchange Factors
Proteins
3 Citations (Scopus)

Cholesterol sulfate is a DOCK2 inhibitor that mediates tissue-specific immune evasion in the eye

Sakurai, T., Uruno, T., Sugiura, Y., Tatsuguchi, T., Yamamura, K., Ushijima, M., Hattori, Y., Kukimoto-Niino, M., Mishima-Tsumagari, C., Watanabe, M., Suematsu, M. & Fuku, Y., Jul 31 2018, In : Science Signaling. 11, 541, eaao4874.

Research output: Contribution to journalArticle

Immune Evasion
Cytokinesis
Tissue
Guanine Nucleotide Exchange Factors
Proteins
3 Citations (Scopus)

Cutting edge: B cells expressing cyclic citrullinated peptide-specific antigen receptor are tolerized in normal conditions

Yamada, H., Ozawa, T., Kishi, H., Okada, S., Nakashima, Y., Muraguchi, A. & Yoshikai, Y., Dec 15 2018, In : Journal of Immunology. 201, 12, p. 3492-3496 5 p.

Research output: Contribution to journalArticle

Antigen Receptors
B-Lymphocytes
Transgenic Mice
Immunoglobulin M
Rheumatoid Arthritis
5 Citations (Scopus)

DOCK1 inhibition suppresses cancer cell invasion and macropinocytosis induced by self-activating Rac1P29S mutation

Tomino, T., Tajiri, H., Tatsuguchi, T., Shirai, T., Oisaki, K., Matsunaga, S., Sanematsu, F., Sakata, D., Yoshizumi, T., Maehara, Y., Kanai, M., Cote, J. F., Fukui, Y. & Uruno, T., Feb 26 2018, In : Biochemical and Biophysical Research Communications. 497, 1, p. 298-304 7 p.

Research output: Contribution to journalArticle

Fibroblasts
Guanine Nucleotide Exchange Factors
Cells
Guanosine Triphosphate
Mutation
46 Citations (Scopus)
Interleukin Receptors
Interleukins
Atopic Dermatitis
Pruritus
Skin
1 Citation (Scopus)

Expression of CRYM in different rat organs during development and its decreased expression in degenerating pyramidal tracts in amyotrophic lateral sclerosis

Hommyo, R., Suzuki, S. O., Abolhassani, N., Hamasaki, H., Shijo, M., Maeda, N., Honda, H., Nakabeppu, Y. & Iwaki, T., Jun 2018, In : Neuropathology. 38, 3, p. 247-259 13 p.

Research output: Contribution to journalArticle

Pyramidal Tracts
Amyotrophic Lateral Sclerosis
Pyramidal Cells
Kidney
Cerebral Cortex

Histone H3.3 sub-variant H3mm7 is required for normal skeletal muscle regeneration

Harada, A., Maehara, K., Ono, Y., Taguchi, H., Yoshioka, K., Kitajima, Y., Xie, Y., Sato, Y., Iwasaki, T., Nogami, J., Okada, S., Komatsu, T., Semba, Y., Takemoto, T., Kimura, H., Kurumizaka, H. & Ohkawa, Y., Dec 1 2018, In : Nature communications. 9, 1, 1400.

Research output: Contribution to journalArticle

skeletal muscle
chromatin
Nucleosomes
regeneration
Histones
2 Citations (Scopus)

Mitochondrial p32/C1qbp Is a Critical Regulator of Dendritic Cell Metabolism and Maturation

Gotoh, K., Morisaki, T., Setoyama, D., Sasaki, K., Yagi, M., Igami, K., Mizuguchi, S., Uchiumi, T., Fukui, Y. & Kang, D., Nov 13 2018, In : Cell Reports. 25, 7, p. 1800-1815.e4

Research output: Contribution to journalArticle

Metabolism
Dendritic Cells
Pyruvic Acid
Citric Acid
Oxidoreductases

Periostin Promotes Fibroblast Migration and Inhibits Muscle Repair After Skeletal Muscle Injury

Hara, M., Yokota, K., Saito, T., Kobayakawa, K., Kijima, K., Yoshizaki, S., Okazaki, K., Yoshida, S., Matsumoto, Y., Harimaya, K., Nakashima, Y. & Okada, S., Aug 15 2018, In : The Journal of bone and joint surgery. American volume. 100, 16, p. e108

Research output: Contribution to journalArticle

Skeletal Muscle
Fibroblasts
Muscles
Wounds and Injuries
Fibrosis
4 Citations (Scopus)

The Disease-modifying Drug Candidate, SAK3 Improves Cognitive Impairment and Inhibits Amyloid beta Deposition in App Knock-in Mice

Izumi, H., Shinoda, Y., Saito, T., Saido, T. C., Sato, K., Yabuki, Y., Matsumoto, Y., Kanemitsu, Y., Tomioka, Y., Abolhassani, N., Nakabeppu, Y. & Fukunaga, K., May 1 2018, In : Neuroscience. 377, p. 87-97 11 p.

Research output: Contribution to journalArticle

Amyloid
Alzheimer Disease
Pharmaceutical Preparations
Rivastigmine
Cognition
4 Citations (Scopus)

The rac activator DOCK2 mediates plasma cell differentiation and IgG antibody production

Ushijima, M., Uruno, T., Nishikimi, A., Sanematsu, F., Kamikaseda, Y., Kunimura, K., Sakata, D., Okada, T. & Fukui, Y., Feb 16 2018, In : Frontiers in Immunology. 9, FEB, 243.

Research output: Contribution to journalArticle

Plasma Cells
Antibody Formation
Cell Differentiation
B-Lymphocytes
Immunoglobulin G
2017

2-Oxoadenosine induces cytotoxicity through intracellular accumulation of 2-oxo-ATP and depletion of ATP but not via the p38 MAPK pathway

Asada, S., Ohta, E., Akimoto, Y., Abolhassani, N., Tsuchimoto, D. & Nakabeppu, Y., Dec 1 2017, In : Scientific Reports. 7, 1, 6528.

Research output: Contribution to journalArticle

Open Access
Adenosine Kinase
p38 Mitogen-Activated Protein Kinases
Adenosine Triphosphate
Cell Death
Nucleoside-Triphosphatase
10 Citations (Scopus)

8-oxoguanine DNA glycosylase (OGG1) deficiency elicits coordinated changes in lipid and mitochondrial metabolism in muscle

Vartanian, V., Tumova, J., Dobrzyn, P., Dobrzyn, A., Nakabeppu, Y., Lloyd, R. S. & Sampath, H., Jul 2017, In : PloS one. 12, 7, e0181687.

Research output: Contribution to journalArticle

DNA Glycosylases
glycosylases
Lipid Metabolism
Metabolism
Muscle
29 Citations (Scopus)

A functional genomics predictive network model identifies regulators of inflammatory bowel disease

Peters, L. A., Perrigoue, J., Mortha, A., Iuga, A., Song, W. M., Neiman, E. M., Llewellyn, S. R., Di Narzo, A., Kidd, B. A., Telesco, S. E., Zhao, Y., Stojmirovic, A., Sendecki, J., Shameer, K., Miotto, R., Losic, B., Shah, H., Lee, E., Wang, M., Faith, J. J. & 18 others, Kasarskis, A., Brodmerkel, C., Curran, M., Das, A., Friedman, J. R., Fukui, Y., Humphrey, M. B., Iritani, B. M., Sibinga, N., Tarrant, T. K., Argmann, C., Hao, K., Roussos, P., Zhu, J., Zhang, B., Dobrin, R., Mayer, L. F. & Schadt, E. E., Oct 1 2017, In : Nature genetics. 49, 10, p. 1437-1449 13 p.

Research output: Contribution to journalArticle

Genomics
Inflammatory Bowel Diseases
Genome-Wide Association Study
Molecular Biology
4 Citations (Scopus)

Antigen availability and DOCK2-driven motility govern CD4+ t cell interactions with dendritic cells in vivo

Ackerknecht, M., Gollmer, K., Germann, P., Ficht, X., Abe, J., Fukui, Y., Swoger, J., Ripoll, J., Sharpe, J. & Stein, J. V., Jul 15 2017, In : Journal of Immunology. 199, 2, p. 520-530 11 p.

Research output: Contribution to journalArticle

Cell Communication
Dendritic Cells
Antigens
T-Lymphocytes
Peptides
5 Citations (Scopus)

Association of MTH1 expression with the tumor malignant potential and poor prognosis in patients with resected lung cancer

Fujishita, T., Okamoto, T., Akamine, T., Takamori, S., Takada, K., Katsura, M., Toyokawa, G., Shoji, F., Shimokawa, M., Oda, Y., Nakabeppu, Y. & Maehara, Y., Jul 1 2017, In : Lung Cancer. 109, p. 52-57 6 p.

Research output: Contribution to journalArticle

Lung Neoplasms
Non-Small Cell Lung Carcinoma
Neoplasms
Antioxidants
Nucleoside-Triphosphatase
13 Citations (Scopus)

Celecoxib and 2,5-dimethylcelecoxib inhibit intestinal cancer growth by suppressing the Wnt/β-catenin signaling pathway

Egashira, I., Takahashi-Yanaga, F., Nishida, R., Arioka, M., Igawa, K., Tomooka, K., Nakatsu, Y., Tsuzuki, T., Nakabeppu, Y., Kitazono, T. & Sasaguri, T., Jan 1 2017, In : Cancer Science. 108, 1, p. 108-115 8 p.

Research output: Contribution to journalArticle

Celecoxib
Intestinal Neoplasms
Catenins
Wnt Signaling Pathway
Growth
12 Citations (Scopus)

Chronic atypical antipsychotics, but not haloperidol, increase neurogenesis in the hippocampus of adult mouse

Chikama, K., Yamada, H., Tsukamoto, T., Kajitani, K., Nakabeppu, Y. & Uchimura, N., Dec 1 2017, In : Brain Research. 1676, p. 77-82 6 p.

Research output: Contribution to journalArticle

Neurogenesis
Haloperidol
Bromodeoxyuridine
olanzapine
Antipsychotic Agents
19 Citations (Scopus)

Comparative profiling of cortical gene expression in Alzheimer's disease patients and mouse models demonstrates a link between amyloidosis and neuroinflammation

Castillo, E., Leon, J., Mazzei, G., Abolhassani, N., Haruyama, N., Saito, T., Saido, T., Hokama, M., Iwaki, T., Ohara, T., Ninomiya, T., Kiyohara, Y., Sakumi, K., Laferla, F. M. & Nakabeppu, Y., Dec 1 2017, In : Scientific reports. 7, 1, 17762.

Research output: Contribution to journalArticle

Gene Expression Profiling
Amyloidosis
Alzheimer Disease
Genes
Neurofibrillary Tangles
5 Citations (Scopus)

Complexity of Stomach–Brain Interaction Induced by Molecular Hydrogen in Parkinson’s Disease Model Mice

Yoshii, Y., Inoue, T., Uemura, Y., Iwasaki, Y., Yada, T., Nakabeppu, Y. & Noda, M., Sep 1 2017, In : Neurochemical Research. 42, 9, p. 2658-2665 8 p.

Research output: Contribution to journalArticle

Ghrelin
Parkinson Disease
Hydrogen
Water
Knockout Mice
4 Citations (Scopus)

Co-regulation of Cxcl1 and versican in the inflammatory response to UVB induced reactive oxygen species in skin photo-tumorigenesis

Takemori, C., Kunisada, M., Yogianti, F., Oka, S., Sakumi, K., Ono, R., Nakabeppu, Y. & Nishigori, C., Feb 1 2017, In : Journal of Dermatological Science. 85, 2, p. 140-143 4 p.

Research output: Contribution to journalLetter

Neoplastic Gene Expression Regulation
Chemokine CXCL1
Radiation-Induced Neoplasms
Versicans
DNA Glycosylases

Correction: Annular PIP3 accumulation controls actin architecture and modulates cytotoxicity at the immunological synapse [The Journal of Experimental Medicine, 210, 12, November 18, (2013) 2721-2737]doi 10.1084/jem.20131324

Le Floc'h, A., Tanaka, Y., Bantilan, N. S., Voisinne, G., Altan-Bonnet, G., Fukui, Y. & Huse, M., Apr 1 2017, In : Journal of Experimental Medicine. 214, 4, 1 p.

Research output: Contribution to journalComment/debate

Immunological Synapses
Biomedical Research
Actins
Emotions
5 Citations (Scopus)

DOCK8 protein regulates macrophage migration through Cdc42 protein activation and LRAP35a protein interaction

Shiraishi, A., Uruno, T., Sanematsu, F., Ushijima, M., Sakata, D., Hara, T. & Fukui, Y., Feb 10 2017, In : Journal of Biological Chemistry. 292, 6, p. 2191-2202 12 p.

Research output: Contribution to journalArticle

cdc42 GTP-Binding Protein
Macrophages
Chemical activation
Guanine Nucleotide Exchange Factors
Proteins
4 Citations (Scopus)

Fenton reaction-induced renal carcinogenesis in Mutyh-deficient mice exhibits less chromosomal aberrations than the rat model

Li, G. H., Akatsuka, S., Chew, S. H., Jiang, L., Nishiyama, T., Sakamoto, A., Takahashi, T., Futakuchi, M., Suzuki, H., Kunihiko, S., Nakabeppu, Y. & Toyokuni, S., Nov 1 2017, In : Pathology International. 67, 11, p. 564-574 11 p.

Research output: Contribution to journalArticle

Chromosome Aberrations
Carcinogenesis
Kidney
Genotype
Methylation
52 Citations (Scopus)

Hippo signaling interactions with Wnt/β-catenin and Notch signaling repress liver tumorigenesis

Kim, W., Khan, S. K., Gvozdenovic-Jeremic, J., Kim, Y., Dahlman, J., Kim, H., Park, O., Ishitani, T., Jho, E. H., Gao, B. & Yang, Y., Jan 3 2017, In : Journal of Clinical Investigation. 127, 1, p. 137-152 16 p.

Research output: Contribution to journalArticle

Catenins
Hepatocellular Carcinoma
Carcinogenesis
Liver
Neoplasms
6 Citations (Scopus)

Induction of intrinsic apoptosis in leukaemia stem cells and in vivo zebrafish model by betulonic acid isolated from Walsura pinnata Hassk (Meliaceae)

Leong, K. H., Mahdzir, M. A., Din, M. F. M., Awang, K., Tanaka, Y., Kulkeaw, K., Ishitani, T. & Sugiyama, D., Mar 15 2017, In : Phytomedicine. 26, p. 11-21 11 p.

Research output: Contribution to journalArticle

Meliaceae
Zebrafish
Leukemia
Stem Cells
Apoptosis
10 Citations (Scopus)
Catenins
Genes
Gene expression
Animals
Gene Expression
38 Citations (Scopus)

Molecular pathophysiology of impaired glucose metabolism, mitochondrial dysfunction, and oxidative DNA damage in Alzheimer's disease brain

Abolhassani, N., Leon, J., Sheng, Z., Oka, S., Hamasaki, H., Iwaki, T. & Nakabeppu, Y., Jan 15 2017, In : Mechanisms of Ageing and Development. 161, Pt A, p. 95-104 15 p.

Research output: Contribution to journalArticle

DNA Damage
Alzheimer Disease
Glucose
DNA Glycosylases
Brain
17 Citations (Scopus)

MTH1 as a nucleotide pool sanitizing enzyme: Friend or foe?

Nakabeppu, Y., Ohta, E. & Abolhassani, N., Jun 1 2017, In : Free Radical Biology and Medicine. 107, p. 151-158 8 p.

Research output: Contribution to journalReview article

Nucleotides
Genes
Genome
Knockout Mice
DNA Glycosylases