Department of Immunobiology and Neuroscience

Research Output

2020

Activation of TLR4 signaling inhibits progression of osteosarcoma by stimulating CD8-positive cytotoxic lymphocytes

Yahiro, K., Matsumoto, Y., Yamada, H., Endo, M., Setsu, N., Fujiwara, T., Nakagawa, M., Kimura, A., Shimada, E., Okada, S., Oda, Y. & Nakashima, Y., May 1 2020, In : Cancer Immunology, Immunotherapy. 69, 5, p. 745-758 14 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

A phospho-switch controls RNF43-mediated degradation of Wnt receptors to suppress tumorigenesis

Tsukiyama, T., Zou, J., Kim, J., Ogamino, S., Shino, Y., Masuda, T., Merenda, A., Matsumoto, M., Fujioka, Y., Hirose, T., Terai, S., Takahashi, H., Ishitani, T., Nakayama, K. I., Ohba, Y., Koo, B. K. & Hatakeyama, S., Dec 1 2020, In : Nature communications. 11, 1, 4586.

Research output: Contribution to journalArticle

Open Access

Cul5-type Ubiquitin Ligase KLHDC1 Contributes to the Elimination of Truncated SELENOS Produced by Failed UGA/Sec Decoding

Okumura, F., Fujiki, Y., Oki, N., Osaki, K., Nishikimi, A., Fukui, Y., Nakatsukasa, K. & Kamura, T., Mar 27 2020, In : iScience. 23, 3, 100970.

Research output: Contribution to journalArticle

Open Access

Dmrt genes participate in the development of Cajal-Retzius cells derived from the cortical hem in the telencephalon

Kikkawa, T., Sakayori, N., Yuuki, H., Katsuyama, Y., Matsuzaki, F., Konno, D., Abe, T., Kiyonari, H. & Osumi, N., Jun 1 2020, In : Developmental Dynamics. 249, 6, p. 698-710 13 p.

Research output: Contribution to journalArticle

DOCK family proteins: Key players in immune surveillance mechanisms

Kunimura, K., Uruno, T. & Fukui, Y., Jan 1 2020, In : International immunology. 32, 1, p. 5-15 11 p.

Research output: Contribution to journalReview article

Open Access
2 Citations (Scopus)

Endfoot regeneration restricts radial glial state and prevents translocation into the outer subventricular zone in early mammalian brain development

Fujita, I., Shitamukai, A., Kusumoto, F., Mase, S., Suetsugu, T., Omori, A., Kato, K., Abe, T., Shioi, G., Konno, D. & Matsuzaki, F., Jan 1 2020, In : Nature Cell Biology. 22, 1, p. 26-37 12 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Environmental aircraft noise aggravates oxidative DNA damage, granulocyte oxidative burst and nitrate resistance in Ogg1–/– mice

Kvandova, M., Filippou, K., Steven, S., Oelze, M., Kalinovic, S., Stamm, P., Frenis, K., Vujacic-Mirski, K., Sakumi, K., Nakabeppu, Y., Bagheri Hosseinabadi, M., Dovinova, I., Epe, B., Münzel, T., Kröller-Schön, S. & Daiber, A., Apr 2 2020, In : Free Radical Research. 54, 4, p. 280-292 13 p.

Research output: Contribution to journalArticle

Generation of the Rat Monoclonal Antibody against the Extracellular Domain of Human CD63 by DNA Immunization

Xu, L., Ihara, K. I., Yoshimura, S., Konno, D., Tachibana, A., Nakanishi, T. & Tachibana, T., Jun 2020, In : Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 39, 3, p. 74-76 3 p.

Research output: Contribution to journalArticle

Mth1 deficiency provides longer survival upon intraperitoneal crocidolite injection in female mice

Funahashi, S., Okazaki, Y., Akatsuka, S., Takahashi, T., Kunihiko, S., Nakabeppu, Y. & Toyokuni, S., Mar 3 2020, In : Free Radical Research. 54, 2-3, p. 195-205 11 p.

Research output: Contribution to journalArticle

OGG1 deficiency alters the intestinal microbiome and increases intestinal inflammation in a mouse model

Simon, H., Vartanian, V., Wong, M. H., Nakabeppu, Y., Sharma, P., Stephen Lloyd, R. & Sampath, H., Jan 1 2020, In : PloS one. 15, 1, e0227501.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Oxidative stress and microglial response in retinitis pigmentosa

Murakami, Y., Nakabeppu, Y. & Sonoda, K. H., Oct 1 2020, In : International journal of molecular sciences. 21, 19, p. 1-16 16 p., 7170.

Research output: Contribution to journalReview article

Open Access

PCBP1 and PCBP2 both bind heavily oxidized RNA but cause opposing outcomes, suppressing or increasing apoptosis under oxidative conditions

Ishii, T., Igawa, T., Hayakawa, H., Fujita, T., Sekiguchi, M. & Nakabeppu, Y., Aug 21 2020, In : The Journal of biological chemistry. 295, 34, p. 12247-12261 15 p.

Research output: Contribution to journalArticle

Surgery-related predictable risk factors influencing postoperative clinical outcomes for thoracic myelopathy caused by ossification of the posterior longitudinal ligament: A multicenter retrospective study

Saiwai, H., Okada, S., Hayashida, M., Harimaya, K., Matsumoto, Y., Kawaguchi, K. I., Kobayakawa, K., Maeda, T., Ohta, H., Shirasawa, K., Tsuchiya, K., Terada, K., Kaji, K., Arizono, T., Saito, T., Fujiwara, M., Iwamoto, Y. & Nakashima, Y., May 2020, In : Journal of Neurosurgery: Spine. 32, 5, p. 703-709 7 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

The beneficial aspects of spasticity in relation to ambulatory ability in mice with spinal cord injury

Yoshizaki, S., Yokota, K., Kubota, K., Saito, T., Tanaka, M., Konno, D. J., Maeda, T., Matsumoto, Y., Nakashima, Y. & Okada, S., May 1 2020, In : Spinal Cord. 58, 5, p. 537-543 7 p.

Research output: Contribution to journalArticle

Tyrosine pre-transfer RNA fragments are linked to p53-dependent neuronal cell death via PKM2

Inoue, M., Hada, K., Shiraishi, H., Yatsuka, H., Fujinami, H., Morisaki, I., Nishida, Y., Matsubara, E., Ishitani, T., Hanada, R., Matsumoto, M., Penninger, J. M., Ihara, K. & Hanada, T., May 7 2020, In : Biochemical and Biophysical Research Communications. 525, 3, p. 726-732 7 p.

Research output: Contribution to journalArticle

2019
3 Citations (Scopus)

Cell competition corrects noisy Wnt morphogen gradients to achieve robust patterning in the zebrafish embryo

Akieda, Y., Ogamino, S., Furuie, H., Ishitani, S., Akiyoshi, R., Nogami, J., Masuda, T., Shimizu, N., Ohkawa, Y. & Ishitani, T., Dec 1 2019, In : Nature communications. 10, 1, 4710.

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)

Clinical Features of Liver Injury Induced by Immune Checkpoint Inhibitors in Japanese Patients

Imoto, K., Kohjima, M., Hioki, T., Kurashige, T., Kurokawa, M., Tashiro, S., Suzuki, H., Kuwano, A., Tanaka, M., Okada, S., Kato, M. & Ogawa, Y., 2019, In : Canadian Journal of Gastroenterology and Hepatology. 2019, 6391712.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Diabetes Mellitus, A risk factor for Alzheimer's Disease

Nakabeppu, Y. (ed.) & Ninomiya, T. (ed.), May 7 2019, Singapore: Springer. 248 p. (Advances in Experimental Medicine and Biology)

Research output: Book/ReportBook

Dmrt factors determine the positional information of cerebral cortical progenitors via differential suppression of homeobox genes

Konno, D., Kishida, C., Maehara, K., Ohkawa, Y., Kiyonari, H., Okada, S. & Matsuzaki, F., Aug 2019, In : Development (Cambridge). 146, 15, dev174243.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Germline mutation: De novo mutation in reproductive lineage cells

Sakumi, K., Jan 1 2019, In : Genes and Genetic Systems. 94, 1, p. 3-12 10 p.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

Macrophage centripetal migration drives spontaneous healing process after spinal cord injury

Kobayakawa, K., Ohkawa, Y., Yoshizaki, S., Tamaru, T., Saito, T., Kijima, K., Yokota, K., Hara, M., Kubota, K., Matsumoto, Y., Harimaya, K., Ozato, K., Masuda, T., Tsuda, M., Tamura, T., Inoue, K., Reggie Edgerton, V., Iwamoto, Y., Nakashima, Y. & Okada, S., May 15 2019, In : Science Advances. 5, 5, eaav5086.

Research output: Contribution to journalArticle

Open Access
7 Citations (Scopus)

Molecular pathophysiology of insulin depletion, mitochondrial dysfunction, and oxidative stress in Alzheimer’s disease brain

Nakabeppu, Y., May 7 2019, Advances in Experimental Medicine and Biology. Springer, p. 27-44 18 p. (Advances in Experimental Medicine and Biology; vol. 1128).

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Citations (Scopus)

Origins of brain insulin and its function

Nakabeppu, Y., May 7 2019, Advances in Experimental Medicine and Biology. Springer, p. 1-11 11 p. (Advances in Experimental Medicine and Biology; vol. 1128).

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Citations (Scopus)

Oxidative stress induces different tissue dependent effects on Mutyh-deficient mice

Chen, J., Huang, Z., Wu, X., Kang, J., Ren, Y., Gao, W., Lu, X., Wang, J., Ding, W., Nakabeppu, Y., Fan, Y. & Wang, Y., Nov 1 2019, In : Free Radical Biology and Medicine. 143, p. 482-493 12 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Pathological changes of distal motor neurons after complete spinal cord injury

Yokota, K., Kubota, K., Kobayakawa, K., Saito, T., Hara, M., Kijima, K., Maeda, T., Katoh, H., Ohkawa, Y., Nakashima, Y. & Okada, S., Jan 9 2019, In : Molecular Brain. 12, 1, 4.

Research output: Contribution to journalArticle

8 Citations (Scopus)

S100A4 Protein Is Essential for the Development of Mature Microfold Cells in Peyer's Patches

Kunimura, K., Sakata, D., Tun, X., Uruno, T., Ushijima, M., Katakai, T., Shiraishi, A., Aihara, R., Kamikaseda, Y., Matsubara, K., Kanegane, H., Sawa, S., Eberl, G., Ohga, S., Yoshikai, Y. & Fukui, Y., Nov 26 2019, In : Cell Reports. 29, 9, p. 2823-2834.e7

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

Selective role of neurokinin B in IL-31–induced itch response in mice

Sakata, D., Uruno, T., Matsubara, K., Andoh, T., Yamamura, K., Magoshi, Y., Kunimura, K., Kamikaseda, Y., Furue, M. & Fukui, Y., Oct 1 2019, In : Journal of Allergy and Clinical Immunology. 144, 4, p. 1130-1133.e8

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)

The acute phase serum zinc concentration is a reliable biomarker for predicting the functional outcome after spinal cord injury

Kijima, K., Kubota, K., Hara, M., Kobayakawa, K., Yokota, K., Saito, T., Yoshizaki, S., Maeda, T., Konno, D., Matsumoto, Y., Nakashima, Y. & Okada, S., Mar 2019, In : EBioMedicine. 41, p. 659-669 11 p.

Research output: Contribution to journalArticle

Open Access
7 Citations (Scopus)
Open Access
3 Citations (Scopus)
2018

An intronic single nucleotide polymorphism in the MUTYH gene is associated with increased risk for HCV-induced hepatocellular carcinoma

Sakurada, A., Miyanishi, K., Tanaka, S., Sato, M., Sakamoto, H., Kawano, Y., Takada, K., Nakabeppu, Y., Kobune, M. & Kato, J., Dec 1 2018, In : Free Radical Biology and Medicine. 129, p. 88-96 9 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

A Novel Autoantibody against Plexin D1 in Patients with Neuropathic Pain

Fujii, T., Yamasaki, R., Iinuma, K., Tsuchimoto, D., Hayashi, Y., Saitoh, B. Y., Matsushita, T., Kido, M. A., Aishima, S., Nakanishi, H., Nakabeppu, Y. & Kira, J. I., Aug 2018, In : Annals of Neurology. 84, 2, p. 208-224 17 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Association of adipocyte enhancer-binding protein 1 with Alzheimer's disease pathology in human hippocampi

Shijo, M., Honda, H., Suzuki, S. O., Hamasaki, H., Hokama, M., Abolhassani, N., Nakabeppu, Y., Ninomiya, T., Kitazono, T. & Iwaki, T., Jan 2018, In : Brain Pathology. 28, 1, p. 58-71 14 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Cholesterol sulfate is a DOCK2 inhibitor that mediates tissue-specific immune evasion in the eye

Sakurai, T., Uruno, T., Sugiura, Y., Tatsuguchi, T., Yamamura, K., Ushijima, M., Hattori, Y., Kukimoto-Niino, M., Mishima-Tsumagari, C., Watanabe, M., Suematsu, M. & Fuku, Y., Jul 31 2018, In : Science Signaling. 11, 541, eaao4874.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Cholesterol sulfate is a DOCK2 inhibitor that mediates tissue-specific immune evasion in the eye

Sakurai, T., Uruno, T., Tatsuguchi, T., Yamamura, K., Ushijima, M., Hattori, Y., Kukimoto-Niino, M., Mishima-Tsumagari, C., Watanabe, M., Suematsu, M. & Fukui, Y., Jul 31 2018, In : Science Signaling. 11, 541

Research output: Contribution to journalArticle

Clinical outcome and prognostic factors of malignant spinal dumbbell tumors

Matsumoto, Y., Kawaguchi, K., Fukushi, J. I., Endo, M., Setsu, N., Iida, K., Baba, S., Saiwai, H., Matsushita, A., Hayashida, M., Okada, S. & Nakashima, Y., 2018, In : Spine Surgery and Related Research. 2, 4, p. 317-323 7 p.

Research output: Contribution to journalArticle

Open Access

Cutting edge: B cells expressing cyclic citrullinated peptide-specific antigen receptor are tolerized in normal conditions

Yamada, H., Ozawa, T., Kishi, H., Okada, S., Nakashima, Y., Muraguchi, A. & Yoshikai, Y., Dec 15 2018, In : Journal of Immunology. 201, 12, p. 3492-3496 5 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

DOCK1 inhibition suppresses cancer cell invasion and macropinocytosis induced by self-activating Rac1P29S mutation

Tomino, T., Tajiri, H., Tatsuguchi, T., Shirai, T., Oisaki, K., Matsunaga, S., Sanematsu, F., Sakata, D., Yoshizumi, T., Maehara, Y., Kanai, M., Cote, J. F., Fukui, Y. & Uruno, T., Feb 26 2018, In : Biochemical and Biophysical Research Communications. 497, 1, p. 298-304 7 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
66 Citations (Scopus)

Expression of CRYM in different rat organs during development and its decreased expression in degenerating pyramidal tracts in amyotrophic lateral sclerosis

Hommyo, R., Suzuki, S. O., Abolhassani, N., Hamasaki, H., Shijo, M., Maeda, N., Honda, H., Nakabeppu, Y. & Iwaki, T., Jun 2018, In : Neuropathology. 38, 3, p. 247-259 13 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Histone H3.3 sub-variant H3mm7 is required for normal skeletal muscle regeneration

Harada, A., Maehara, K., Ono, Y., Taguchi, H., Yoshioka, K., Kitajima, Y., Xie, Y., Sato, Y., Iwasaki, T., Nogami, J., Okada, S., Komatsu, T., Semba, Y., Takemoto, T., Kimura, H., Kurumizaka, H. & Ohkawa, Y., Dec 1 2018, In : Nature communications. 9, 1, 1400.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Lymphatics in the liver

Tanaka, M. & Iwakiri, Y., Aug 2018, In : Current Opinion in Immunology. 53, p. 137-142 6 p.

Research output: Contribution to journalReview article

8 Citations (Scopus)

Mitochondrial p32/C1qbp Is a Critical Regulator of Dendritic Cell Metabolism and Maturation

Gotoh, K., Morisaki, T., Setoyama, D., Sasaki, K., Yagi, M., Igami, K., Mizuguchi, S., Uchiumi, T., Fukui, Y. & Kang, D., Nov 13 2018, In : Cell Reports. 25, 7, p. 1800-1815.e4

Research output: Contribution to journalArticle

10 Citations (Scopus)

Periostin Promotes Fibroblast Migration and Inhibits Muscle Repair After Skeletal Muscle Injury

Hara, M., Yokota, K., Saito, T., Kobayakawa, K., Kijima, K., Yoshizaki, S., Okazaki, K., Yoshida, S., Matsumoto, Y., Harimaya, K., Nakashima, Y. & Okada, S., Aug 15 2018, In : The Journal of bone and joint surgery. American volume. 100, 16, p. e108

Research output: Contribution to journalArticle

2 Citations (Scopus)

Purification of zebrafish erythrocytes as a means of identifying a novel regulator of haematopoiesis

Kulkeaw, K., Inoue, T., Ishitani, T., Nakanishi, Y., Zon, L. I. & Sugiyama, D., Feb 1 2018, In : British Journal of Haematology. 180, 3, p. 420-431 12 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
Open Access

The Disease-modifying Drug Candidate, SAK3 Improves Cognitive Impairment and Inhibits Amyloid beta Deposition in App Knock-in Mice

Izumi, H., Shinoda, Y., Saito, T., Saido, T. C., Sato, K., Yabuki, Y., Matsumoto, Y., Kanemitsu, Y., Tomioka, Y., Abolhassani, N., Nakabeppu, Y. & Fukunaga, K., May 1 2018, In : Neuroscience. 377, p. 87-97 11 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)