Department of Immunobiology and Neuroscience

Research Output 1981 2019

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Review article
2018
38 Citations (Scopus)
Interleukin Receptors
Interleukins
Atopic Dermatitis
Pruritus
Skin
4 Citations (Scopus)

Lymphatics in the liver

Tanaka, M. & Iwakiri, Y., Aug 1 2018, In : Current Opinion in Immunology. 53, p. 137-142 6 p.

Research output: Contribution to journalReview article

Lymphatic System
Liver
Liver Diseases
Lymphangiogenesis
Lymphatic Vessels
2016

Galectin-1 and galectin-3 as key molecules for peripheral nerve degeneration and regeneration

Takaku, S., Niimi, N., Kadoya, T., Yako, H., Tsukamoto, M., Sakumi, K., Nakabeppu, Y., Horie, H. & Sango, K., Jun 5 2016, In : AIMS Molecular Science. 3, 3, p. 325-337 13 p.

Research output: Contribution to journalReview article

Open Access
2014
74 Citations (Scopus)
nucleotides
DNA Glycosylases
Nucleotides
Cell Survival
Carcinogenesis
2013
37 Citations (Scopus)

Immune regulatory functions of DOCK family proteins in health and disease

Nishikimi, A., Kukimoto-Niino, M., Yokoyama, S. & Fukui, Y., Sep 10 2013, In : Experimental Cell Research. 319, 15, p. 2343-2349 7 p.

Research output: Contribution to journalReview article

Guanine Nucleotide Exchange Factors
Health
Proteins
PDZ Domains
rho GTP-Binding Proteins
40 Citations (Scopus)

Nemo-like kinase, a multifaceted cell signaling regulator

Ishitani, T. & Ishitani, S., Jan 1 2013, In : Cellular Signalling. 25, 1, p. 190-197 8 p.

Research output: Contribution to journalReview article

Phosphotransferases
Catenins
Activins
Wnt Signaling Pathway
Mitogen-Activated Protein Kinase Kinases
2012
3 Citations (Scopus)

Protein kinase NLK, that fine-tunes the activity of multiple intracellular signaling pathways

Ishitani, T., 2012, In : Seikagaku. The Journal of Japanese Biochemical Society. 84, 1, p. 39-42 4 p.

Research output: Contribution to journalReview article

Intracellular Signaling Peptides and Proteins
Lithium Chloride
Signal transduction
Phosphorylation
Protein-Serine-Threonine Kinases

The mechanism controlling leukocyte trafficking for acquired immune responses

Fukui, Y., Dec 1 2012, In : Seikagaku. 84, 3, p. 189-194 6 p.

Research output: Contribution to journalReview article

rap1 GTP-Binding Proteins
cdc42 GTP-Binding Protein
rac GTP-Binding Proteins
rho GTP-Binding Proteins
Chemokine Receptors
28 Citations (Scopus)
Neurodegenerative diseases
Neurodegenerative Diseases
Oxidation-Reduction
Antioxidants
Gases
2011
41 Citations (Scopus)

DNA glycosylase encoded by MUTYH functions as a molecular switch for programmed cell death under oxidative stress to suppress tumorigenesis

Oka, S. & Nakabeppu, Y., Apr 1 2011, In : Cancer Science. 102, 4, p. 677-682 6 p.

Research output: Contribution to journalReview article

DNA Glycosylases
Carcinogenesis
Oxidative Stress
Cell Death
DNA
9 Citations (Scopus)

Nucleotides function as endogenous chemical sensors for oxidative stress signaling

Ihara, H., Sawa, T., Nakabeppu, Y. & Akaike, T., Jan 1 2011, In : Journal of Clinical Biochemistry and Nutrition. 48, 1, p. 33-39 7 p.

Research output: Contribution to journalReview article

Oxidative stress
Chemical sensors
Oxidative Stress
Nucleotides
Nitrogen Oxides
9 Citations (Scopus)

Therapeutic effects of hydrogen in animal models of Parkinson's disease

Fujita, K., Nakabeppu, Y. & Noda, M., Sep 19 2011, In : Parkinson's Disease. 307875.

Research output: Contribution to journalReview article

Therapeutic Uses
Parkinson Disease
Hydrogen
Animal Models
Oxidopamine
2010
8 Citations (Scopus)

A comprehensive screening system for damaged nucleotide-binding proteins

Tsuchimoto, D., Iyama, T., Nonaka, M., Abolhassani, N., Ohta, E., Kunihiko, S. & Nakabeppu, Y., Nov 28 2010, In : Mutation Research - Genetic Toxicology and Environmental Mutagenesis. 703, 1, p. 37-42 6 p.

Research output: Contribution to journalReview article

Inosine Triphosphate
Carrier Proteins
Nucleotides
Inosine Monophosphate
Adenosine Triphosphate
25 Citations (Scopus)

Emerging roles of prostanoids in T cell-mediated immunity

Sakata, D., Yao, C. & Narumiya, S., Aug 1 2010, In : IUBMB Life. 62, 8, p. 591-596 6 p.

Research output: Contribution to journalReview article

T-cells
Cellular Immunity
Prostaglandins
T-Lymphocytes
Immune System Diseases
26 Citations (Scopus)

ITPA protein, an enzyme that eliminates deaminated purine nucleoside triphosphates in cells

Kunihiko, S., Abolhassani, N., Behmanesh, M., Iyama, T., Tsuchimoto, D. & Nakabeppu, Y., Nov 28 2010, In : Mutation Research - Genetic Toxicology and Environmental Mutagenesis. 703, 1, p. 43-50 8 p.

Research output: Contribution to journalReview article

Inosine Triphosphate
Purine Nucleosides
Enzymes
Proteins
Embryonic Structures
49 Citations (Scopus)
Nucleoside-Triphosphatase
Purine Nucleosides
Cell Aging
Mutagenesis
Cell Death
81 Citations (Scopus)

Prostaglandin E2, an immunoactivator

Sakata, D., Yao, C. & Narumiya, S., Feb 8 2010, In : Journal of Pharmacological Sciences. 112, 1, p. 1-5 5 p.

Research output: Contribution to journalReview article

Immunologic Adjuvants
Dinoprostone
Immune System Diseases
Immunosuppressive Agents
Prostaglandin E Receptors
2007
160 Citations (Scopus)

Oxidative damage in nucleic acids and Parkinson's disease

Nakabeppu, Y., Tsuchimoto, D., yamaguchi, H. & Kunihiko, S., Apr 1 2007, In : Journal of Neuroscience Research. 85, 5, p. 919-934 16 p.

Research output: Contribution to journalReview article

Mitochondrial DNA
Nucleic Acids
DNA Glycosylases
Parkinson Disease
Dopaminergic Neurons
20 Citations (Scopus)

Regeneration-based therapies for spinal cord injuries

Okano, H., Kaneko, S., Okada, S., Iwanami, A., Nakamura, M. & Toyama, Y., Jul 1 2007, In : Neurochemistry International. 51, 2-4 SPEC. ISS., p. 68-73 6 p.

Research output: Contribution to journalReview article

Spinal Cord Injuries
Regeneration
Central Nervous System
Developmental Biology
Regenerative Medicine
73 Citations (Scopus)

Significance of error-avoiding mechanisms for oxidative DNA damage in carcinogenesis

Tsuzuki, T., Nakatsu, Y. & Nakabeppu, Y., Apr 1 2007, In : Cancer Science. 98, 4, p. 465-470 6 p.

Research output: Contribution to journalReview article

Mutagenesis
DNA Damage
Carcinogenesis
Adenine
Escherichia coli
2006
61 Citations (Scopus)
Nucleoside-Triphosphatase
Purine Nucleosides
Purine Nucleotides
Cytotoxicity
Brain
2005
17 Citations (Scopus)

Regulation of the neuronal fate by ΔFosB and its downstream target, galectin-1

Miura, T., Ohnishi, Y., Kurushima, H., Horie, H., Kadoya, T. & Nakabeppu, Y., Jun 1 2005, In : Current Drug Targets. 6, 4, p. 437-444 8 p.

Research output: Contribution to journalReview article

Galectin 1
Cell death
Cell Death
Cells
Transcription Factor AP-1
48 Citations (Scopus)

Role of IL-6 in spinal cord injury in a mouse model

Nakamura, M., Okada, S., Toyama, Y. & Okano, H., Jun 1 2005, In : Clinical Reviews in Allergy and Immunology. 28, 3, p. 197-203 7 p.

Research output: Contribution to journalReview article

Neural Stem Cells
Spinal Cord Injuries
Interleukin-6
Neuroglia
Astrocytes
2004
75 Citations (Scopus)
Mutagenesis
Cell death
Nucleic Acids
DNA Glycosylases
Cell Death
2003
33 Citations (Scopus)

Thymic generation and selection of CD25+CD4+ regulatory T cells: Implications of their broad repertoire and high self-reactivity for the maintenance of immunological self-tolerance

Sakaguchi, S., Hori, S., Fukui, Y., Sasazuki, T., Sakaguchi, N., Takahashi, T. & Bach, Dec 1 2003, In : Novartis Foundation symposium. 252, p. 6-23 18 p.

Research output: Contribution to journalReview article

Self Tolerance
Regulatory T-Lymphocytes
Thymus Gland
T-Lymphocytes
Ligands
2002

A critical role of the CDM family molecule DOCK2 in lymphocyte migration

Fukui, Y., Jan 1 2002, In : Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme. 47, 16 Suppl, p. 2194-2199 6 p.

Research output: Contribution to journalReview article

rac1 GTP-Binding Protein
rac GTP-Binding Proteins
GTPase-Activating Proteins
Cytoskeleton
Cell Movement
20 Citations (Scopus)

The postsynaptic density and dendritic raft localization of PSD-Zip70, which contains an N-myristoylation sequence and leucine-zipper motifs

Konno, D., Ko, J. A., Usui, S., Hori, K., Maruoka, H., Inui, M., Fujikado, T., Tano, Y., Suzuki, T., Tohyama, K. & Sobue, K., Dec 1 2002, In : Journal of Cell Science. 115, 23, p. 4695-4706 12 p.

Research output: Contribution to journalReview article

Post-Synaptic Density
Leucine Zippers
Membranes
Cell Membrane
Synaptic Membranes
2001
94 Citations (Scopus)

Molecular genetics and structural biology of human MutT homolog, MTH1

Nakabeppu, Y., Jun 2 2001, In : Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 477, 1-2, p. 59-70 12 p.

Research output: Contribution to journalReview article

Single Nucleotide Polymorphism
Molecular Biology
Exons
Messenger RNA
Nucleoside-Triphosphatase
1996
46 Citations (Scopus)

DNA-repair methyltransferase as a molecular device for preventing mutation and cancer

Sekiguchi, M., Nakabeppu, Y., Kunihiko, S. & Tuzuki, T., Jan 1 1996, In : Journal of Cancer Research and Clinical Oncology. 122, 4, p. 199-206 8 p.

Research output: Contribution to journalReview article

Methyltransferases
DNA Repair
Equipment and Supplies
Mutation
DNA
1988
580 Citations (Scopus)

Regulation and expression of the adaptive response to alkylating agents

Lindahl, T., Sedgwick, B., Sekiguchi, M. & Nakabeppu, Y., Jan 1 1988, In : Annual Review of Biochemistry. 57, p. 133-157 25 p.

Research output: Contribution to journalReview article

Alkylating Agents
Repair
DNA
Mutagens
Proteins