Department of Medical Education

Research Output

An ATP-sensitive potassium channel activator reduces infarct volume in focal cerebral ischemia in rats

Takaba, H., Nagao, T., Yao, H., Kitazono, T., Ibayashi, S. & Fujishima, M., Oct 18 1997, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 273, 2 42-2, p. R583-R586

Research output: Contribution to journalArticle

29 Citations (Scopus)

An Embolic Stroke in a Patient With PROC p.Lys193del

Ueki, K., Nakamura, K., Wakisaka, Y., Wada, S., Yoshikawa, Y., Matsumoto, S., Hotta, T., Kang, D., Kitazono, T. & Ago, T., Jan 1 2020, (Accepted/In press) In : Journal of Stroke and Cerebrovascular Diseases. 104597.

Research output: Contribution to journalArticle

A new aspect of arsenic, an old poison

Hirata, M., Sep 1999, In : Fukuoka igaku zasshi = Hukuoka acta medica. 90, 9, p. 347-352 6 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

A new role of Pro-73 of p47phox in the activation of neutrophil NADPH oxidase

Nagasawa, T., Ebisu, K., Inoue, Y., Miyano, K. & Tamura, M., Aug 1 2003, In : Archives of Biochemistry and Biophysics. 416, 1, p. 92-100 9 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

A new type of O2--generating tool for oxidative stress studies by remodeling neutrophil NADPH oxidase

Tamura, M., Nagasawa, T., Tange, T., Miyano, K., Kobayashi, S. I., Nakai, T. & Miura, S., Dec 6 2005, In : Journal of Biotechnology. 120, 4, p. 421-429 9 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of β-catenin

Kitagawa, M., Hatakeyama, S., Shirane, M., Matsumoto, M., Ishida, N., Hattori, K., Nakamichi, I., Kikuchi, A., Nakayama, K. I. & Nakayama, K., May 4 1999, In : EMBO Journal. 18, 9, p. 2401-2410 10 p.

Research output: Contribution to journalArticle

445 Citations (Scopus)

Angiopoietin-like protein 2 and risk of type 2 diabetes in a general Japanese population: The Hisayama study

Doi, Y., Ninomiya, T., Hirakawa, Y., Takahashi, O., Mukai, N., Hata, J., Iwase, M., Kitazono, T., Oike, Y. & Kiyohara, Y., Jan 1 2013, In : Diabetes care. 36, 1, p. 98-100 3 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)

Angiopoietin-like protein 2 is associated with chronic kidney disease in a general Japanese population: The Hisayama Study

Usui, T., Ninomiya, T., Nagata, M., Takahashi, O., Doi, Y., Hata, J., Fukuhara, M., Kitazono, T., Oike, Y. & Kiyohara, Y., Aug 28 2013, In : Circulation Journal. 77, 9, p. 2311-2317 7 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Angiotensin-converting enzyme inhibitors versus angiotensin receptor blockers in hypertensive patients with myocardial infarction or heart failure: a systematic review and meta-analysis

Ohtsubo, T., Shibata, R., Kai, H., Okamoto, R., Kumagai, E., Kawano, H., Fujiwara, A., Kitazono, T., Murohara, T. & Arima, H., May 1 2019, In : Hypertension Research. 42, 5, p. 641-649 9 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Angiotensin-converting enzyme inhibitor usage and acute kidney injury: A secondary analysis of RENAL study outcomes

RENAL STUDY INVESTIGATORS & ANZICS CLINICAL TRIALS GROUP, Oct 1 2014, In : Nephrology. 19, 10, p. 617-622 6 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
11 Citations (Scopus)

Angiotensin II acts at AT1 receptors in the nucleus of the solitary tract to attenuate the baroreceptor reflex

Matsumura, K., Averill, D. B. & Ferrario, C. M., Nov 1 1998, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 275, 5 44-5, p. R1611-R1619

Research output: Contribution to journalArticle

96 Citations (Scopus)

Angiotensin II receptor antagonists as the agents to treat cerebrovascular disease

Kitazono, T. & Fujishima, M., May 1999, In : Nippon rinsho. Japanese journal of clinical medicine. 57, 5, p. 1168-1175 8 p.

Research output: Contribution to journalReview article

1 Citation (Scopus)

Angiotensin II receptor-neprilysin inhibitor sacubitril/valsartan improves endothelial dysfunction in spontaneously hypertensive rats

Seki, T., Goto, K., Kansui, Y., Ohtsubo, T., Matsumura, K. & Kitazono, T., Oct 1 2017, In : Journal of the American Heart Association. 6, 10, e006617.

Research output: Contribution to journalArticle

13 Citations (Scopus)
5 Citations (Scopus)

An instrument for evaluating clinical teaching in Japan: Content validity and cultural sensitivity

Kikukawa, M., Stalmeijer, R. E., Emura, S., Roff, S. & Scherpbier, A. J. J. A., Aug 28 2014, In : BMC Medical Education. 14, 1, 179.

Research output: Contribution to journalArticle

6 Citations (Scopus)
36 Citations (Scopus)

Ankle-brachial blood pressure index predicts cardiovascular events and mortality in Japanese patients with chronic kidney disease not on dialysis

Yoshitomi, R., Nakayama, M., Ura, Y., Kuma, K., Nishimoto, H., Fukui, A., Ikeda, H., Tsuchihashi, T., Tsuruya, K. & Kitazono, T., Dec 11 2014, In : Hypertension Research. 37, 12, p. 1050-1055 6 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Ankle-brachial index measured by oscillometry is predictive for cardiovascular disease and premature death in the Japanese population: An individual participant data meta-analysis

collaborative group for the Japan Brachial-Ankle pulse wave VELocity individual participant data meta-analysis of prospective studies to examine the significance of the Ankle-Brachial Index (J-BAVEL-ABI), Aug 2018, In : Atherosclerosis. 275, p. 141-148 8 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

A noninferiority confirmatory trial of prasugrel versus clopidogrel in Japanese patients with non-cardioembolic stroke: rationale and study design for a randomized controlled trial–PRASTRO-I trial

Nagao, T., Toyoda, K., Kitagawa, K., Kitazono, T., Yamagami, H., Uchiyama, S., Tanahashi, N., Matsumoto, M., Minematsu, K., Nagata, I., Nishikawa, M., Nanto, S., Abe, K., Ikeda, Y. & Ogawa, A., Apr 13 2018, In : Expert Opinion on Pharmacotherapy. 19, 6, p. 529-535 7 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

A nonsynonymous SNP in PRKCH (protein kinase C η) increases the risk of cerebral infarction

Kubo, M., Hata, J., Ninomiya, T., Matsuda, K., Yonemoto, K., Nakano, T., Matsushita, T., Yamazaki, K., Ohnishi, Y., Saito, S., Kitazono, T., Ibayashi, S., Sueishi, K., Iida, M., Nakamura, Y. & Kiyohara, Y., Feb 1 2007, In : Nature genetics. 39, 2, p. 212-217 6 p.

Research output: Contribution to journalArticle

158 Citations (Scopus)

Antagonistic effects of an alternative splice variant of human IL-4, IL- 4δ2, on IL-4 activities in human monocytes and B cells

Arinobu, Y., Atamas, S. P., Otsuka, T., Niiro, H., Yamaoka, K., Mitsuyasu, H., Niho, Y., Hamasaki, N., White, B. & Izuhara, K., Feb 1 1999, In : Cellular Immunology. 191, 2, p. 161-167 7 p.

Research output: Contribution to journalArticle

66 Citations (Scopus)

Antegrade internal carotid artery collateral flow and cerebral blood flow in patients with common carotid artery occlusion

Nakamura, A., Wakugawa, Y., Yasaka, M., Ogata, T., Yasumori, K., Kitazono, T. & Okada, Y., Oct 1 2012, In : Journal of Ultrasound in Medicine. 31, 10, p. 1561-1566 6 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Anti-angiogenic effects of differentiation-inducing factor-1 involving VEGFR-2 expression inhibition independent of the Wnt/β-catenin signaling pathway.

Yoshihara, T., Takahashi-Yanaga, F., Shiraishi, F., Morimoto, S., Watanabe, Y., Hirata, M., Hoka, S. & Sasaguri, T., 2010, In : Molecular cancer. 9, 1 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Anti-Cyclic Citrullinated Peptide Antibody-Positive Meningoencephalitis in the Preclinical Period of Rheumatoid Arthritis

Shibahara, T., Matsushita, T., Matsuo, R., Fukushima, Y., Fukuda, K., Sugimori, H., Kamouchi, M., Kitazono, T. & Ago, T., Jan 1 2016, In : Case Reports in Neurology. 8, 2, p. 156-160 5 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Anti-monocyte chemoattractant protein-1 gene therapy protects against focal brain ischemia in hypertensive rats

Kumai, Y., Ooboshi, H., Takada, J., Kamouchi, M., Kitazono, T., Egashira, K., Ibayashi, S. & Iida, M., Dec 2004, In : Journal of Cerebral Blood Flow and Metabolism. 24, 12, p. 1359-1368 10 p.

Research output: Contribution to journalArticle

50 Citations (Scopus)

Antioxidant ameliorates cisplatin-induced renal tubular cell death through inhibition of death receptor-mediated pathways

Tsuruya, K., Tokumoto, M., Ninomiya, T., Hirakawa, M., Masutani, K., Taniguchi, M., Fukuda, K., Kanai, H., Hirakata, H. & Iida, M., Aug 1 2003, In : American Journal of Physiology - Renal Physiology. 285, 2 54-2, p. F208-F218

Research output: Contribution to journalArticle

89 Citations (Scopus)

Antisense inhibition of angiotensinogen attenuates vasopressin release in the paraventricular hypothalamic nucleus of spontaneously hypertensive rats

Kagiyama, S., Tsuchihashi, T., Abe, I., Matsumura, K. & Fujishima, M., May 22 1999, In : Brain Research. 829, 1-2, p. 120-124 5 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Anti-tumor necrosis factor therapy decreases the risk of initial intestinal surgery after diagnosis of Crohn’s disease of inflammatory type

Nagata, Y., Esaki, M., Moriyama, T., Hirano, A., Umeno, J., Maehata, Y., Torisu, T., Matsumoto, T. & Kitazono, T., Apr 1 2019, In : Journal of gastroenterology. 54, 4, p. 330-338 9 p.

Research output: Contribution to journalArticle

Anti-xa activity and event risk in patients with direct factor xa inhibitors initiated early after stroke

Wada, S., Toyoda, K., Sato, S., Matsuki, T., Okata, T., Kumamoto, M., Tagawa, N., Inoue, M., Okamoto, A., Ihara, M., Kitazono, T., Miyata, T. & Koga, M., Jan 1 2018, In : Circulation Journal. 82, 11, p. 2872-2879 8 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

An update on novel oral anticoagulants

Ago, T., Wakisaka, Y. & Kuroda, J., Jan 1 2015, In : Japanese Journal of Neurosurgery. 24, 4, p. 220-225 6 p.

Research output: Contribution to journalArticle

Aortic dissection as a possible underlying cause of acute ischemic stroke

Kamouchi, M., Jul 24 2015, In : Circulation Journal. 79, 8, p. 1697-1698 2 p.

Research output: Contribution to journalEditorial

4 Citations (Scopus)

A peptide-based human T cell leukemia virus type I vaccine containing T and B cell epitopes that induces high titers of neutralizing antibodies

Baba, E., Nakamura, M., Ohkuma, K., Kira, J. I., Tanaka, Y., Nakano, S. & Niho, Y., Jan 1 1995, In : Journal of Immunology. 154, 1, p. 399-412 14 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

APOE and CYP2E1 polymorphisms, alcohol consumption, and Parkinson's disease in a Japanese population

Kiyohara, C., Miyake, Y., Koyanagi, M., Fujimoto, T., Shirasawa, S., Tanaka, K., Fukushima, W., Sasaki, S., Tsuboi, Y., Yamada, T., Oeda, T., Miki, T., Kawamura, N., Sakae, N., Fukuyama, H., Hirota, Y. & Nagai, M., Sep 1 2011, In : Journal of Neural Transmission. 118, 9, p. 1335-1344 10 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Apolipoprotein E genotype, serum lipids, and colorectal adenomas in Japanese men

Shinomiya, S., Sasaki, J., Kiyohara, C., Tsuji, E., Inoue, H., Marugame, T., Handa, K., Hayabuchi, H., Hamada, H., Eguchi, H., Fukushima, Y. & Kono, S., Mar 10 2001, In : Cancer Letters. 164, 1, p. 33-40 8 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Apolipoprotein genotype for prediction of Alzheimer's disease in older Japanese: The hisayama study

Ohara, T., Ninomiya, T., Kubo, M., Hirakawa, Y., Doi, Y., Hata, J., Iwaki, T., Kanba, S. & Kiyohara, Y., Jun 1 2011, In : Journal of the American Geriatrics Society. 59, 6, p. 1074-1079 6 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)
1 Citation (Scopus)

Apparent Treatment-Resistant Hypertension and Cardiovascular Risk in Hemodialysis Patients: Ten-Year Outcomes of the Q-Cohort Study

Tanaka, S., Ninomiya, T., Hiyamuta, H., Taniguchi, M., Tokumoto, M., Masutani, K., Ooboshi, H., Nakano, T., Tsuruya, K. & Kitazono, T., Dec 1 2019, In : Scientific reports. 9, 1, 1043.

Research output: Contribution to journalArticle

1 Citation (Scopus)

A practical guide to research: design, execution, and publication.

ISAKOS Scientific Committee, S. C., Audigé, L., Ayeni, O. R., Bhandari, M., Boyle, B. W., Briggs, K. K., Chan, K., Chaney-Barclay, K., Do, H. T., Ferretti, M., Fu, F. H., Goldhahn, J., Goldhahn, S., Hidaka, C., Hoang-Kim, A., Karlsson, J., Krych, A. J., LaPrade, R. F., Levy, B. A., Lubowitz, J. H. & 16 others, Lyman, S., Ma, Y., Marx, R. G., Mohtadi, N., Marcheggiani Muccioli, G. M., Nakamura, N., Nguyen, J., Poehling, G. G., Poehling, G. G., Rosenberg, N., Shea, K. P., Sohani, Z. N., Soudry, M., Voineskos, S., Zaffagnini, S. & International Society of Arthroscopy, Knee Surgery, M., Apr 1 2011, In : Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association. 27, 4 Suppl, p. S1-112

Research output: Contribution to journalArticle

11 Citations (Scopus)

A prospective study of dietary salt intake and gastric cancer incidence in a defined Japanese population: The Hisayama study

Shikata, K., Kiyohara, Y., Kubo, M., Yonemoto, K., Ninomiya, T., Shirota, T., Tanizaki, Y., Doi, Y., Tanaka, K., Oishi, Y., Matsumoto, T. & Iida, M., Jul 1 2006, In : International Journal of Cancer. 119, 1, p. 196-201 6 p.

Research output: Contribution to journalArticle

161 Citations (Scopus)

Arachidonic acid induces direct interaction of the p67phox-Rac complex with the phagocyte oxidase Nox2, leading to superoxide production

Matono, R., Miyano, K., Kiyohara, T. & Sumimoto, H., Jan 1 2014, In : Journal of Biological Chemistry. 289, 36, p. 24874-24884 11 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

A region N-terminal to the tandem SH3 domain of p47phox plays a crucial role in the activation of the phagocyte NADPH oxidase

Taura, M., Miyano, K., Minakami, R., Kamakura, S., Takeya, R. & Sumimoto, H., Apr 15 2009, In : Biochemical Journal. 419, 2, p. 329-338 10 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

A role of aryl hydrocarbon hydroxylase inducibility in susceptibility to lung carcinogenesis

Kiyohara, C. & Hirohata, T., Dec 1 1993, In : Japanese Journal of Hygiene. 48, 6, p. 1027-1036 10 p.

Research output: Contribution to journalReview article

2 Citations (Scopus)

Arterial Spin Labeling Magnetic Resonance Imaging for Differentiating Acute Ischemic Stroke from Epileptic Disorders

Kanazawa, Y., Arakawa, S., Shimogawa, T., Hagiwara, N., Haga, S., Morioka, T., Ooboshi, H., Ago, T. & Kitazono, T., Jun 2019, In : Journal of Stroke and Cerebrovascular Diseases. 28, 6, p. 1684-1690 7 p.

Research output: Contribution to journalArticle

Arterial stiffness and QT interval prolongation in a general population: The Hisayama study

Maebuchi, D., Arima, H., Ninomiya, T., Yonemoto, K., Kubo, M., Doi, Y., Tanizaki, Y., Matsumura, K., Iida, M. & Kiyohara, Y., Nov 11 2008, In : Hypertension Research. 31, 7, p. 1339-1345 7 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Aryl hydrocarbon hydroxylase activity in Yusho patients

Nagayama, J., Kiyohara, C., Nakamura, Y., Ikeda, M., Asahi, M. & Hirohata, T., 1987, In : Chemosphere. 16, 8-9, p. 2073-2078 6 p.

Research output: Contribution to journalArticle

Aryl hydrocarbon hydroxylase activity levels in the hepatic microsomal fraction from MC- or TCDD-treated mice: a comparison between aromatic hydrocarbon responsive and non-responsive strains

Kiyohara, C., Mohri, N., Hirohata, T., Haraguchi, K., Masuda, Y. & Nagayama, J., Jun 1990, In : Toxicology Letters. 52, 1, p. 73-80 8 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Aryl hydrocarbon receptor mediates laminar fluid shear stress-induced CYP1A1 activation and cell cycle arrest in vascular endothelial cells

Han, Z., Miwa, Y., Obikane, H., Mitsumata, M., Takahashi-Yanaga, F., Morimoto, S. & Sasaguri, T., Mar 1 2008, In : Cardiovascular research. 77, 4, p. 809-818 10 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Assessing risk prediction models using individual participant data from multiple studies

The Emerging Risk Factors Collaboration, Mar 1 2014, In : American journal of epidemiology. 179, 5, p. 621-632 12 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Assessment of the role for Rho family GTPases in NADPH oxidase activation

Miyano, K. & Sumimoto, H., Jan 20 2012, Rho GTPases: Methods and Protocols. Rivero, F. (ed.). p. 195-212 18 p. (Methods in Molecular Biology; vol. 827).

Research output: Chapter in Book/Report/Conference proceedingChapter

24 Citations (Scopus)