Department of Medical Education

Research Output 1983 2020

20 Citations (Scopus)

Phenylarsine oxide inhibits tyrosine phosphorylation of phospholipase Cγ2 in human platelets and phospholipase Cγ1 in NIH-3T3 fibroblasts

Yanaga, F., Asselin, J., Schieven, G. L. & Watson, S. P., Jul 17 1995, In : FEBS Letters. 368, 2, p. 377-380 4 p.

Research output: Contribution to journalArticle

Phosphorylation
Phospholipases
Fibroblasts
Platelets
Tyrosine
1 Citation (Scopus)

Pharmacokinetics Study of Low Dose of Metformin Clinically Used in Japan

Iwase, M., Nohara, S., Sasaki, N., Himeno, T., Nishida, M., Yoshinari, M., Yoshizumi, H., Mukai, N., Doi, Y., Morizono, S., Asano, T., Tsutsu, N. & Iida, M., May 19 2004, In : Journal of the Japan Diabetes Society. 47, 3, p. 197-201 5 p.

Research output: Contribution to journalArticle

Metformin
Japan
Pharmacokinetics
Literature
Oral Administration
5 Citations (Scopus)

Personal indium exposure concentration in respirable dusts and serum indium level

Iwasawa, S., Nakano, M., Miyauchi, H., Tanaka, S., Kawasumi, Y., Higashikubo, I., Tanaka, A., Hirata, M. & Omae, K., Jan 1 2017, In : Industrial health. 55, 1, p. 87-90 4 p.

Research output: Contribution to journalArticle

Indium
Dust
Serum
229 Citations (Scopus)

Peroxiredoxin family proteins are key initiators of post-ischemic inflammation in the brain

Shichita, T., Hasegawa, E., Kimura, A., Morita, R., Sakaguchi, R., Takada, I., Sekiya, T., Ooboshi, H., Kitazono, T., Yanagawa, T., Ishii, T., Takahashi, H., Mori, S., Nishibori, M., Kuroda, K., Akira, S., Miyake, K. & Yoshimura, A., Jun 1 2012, In : Nature medicine. 18, 6, p. 911-917 7 p.

Research output: Contribution to journalArticle

Peroxiredoxins
Encephalitis
Macrophages
Brain
Macrophage Activation
11 Citations (Scopus)

Peripheral tolerance and the qualitative characteristics of autoreactive T cell clones in primary biliary cirrhosis

Kawano, A., Shimoda, S., Kamihira, T., Ishikawa, F., Niiro, H., Soejima, Y., Taketomi, A., Maehara, Y., Nakamura, M., Komori, A., Migita, K., Ishibashi, H., Azuma, M., Gershwin, M. E. & Harada, M., Sep 1 2007, In : Journal of Immunology. 179, 5, p. 3315-3324 10 p.

Research output: Contribution to journalArticle

Peripheral Tolerance
Biliary Liver Cirrhosis
Clone Cells
T-Lymphocytes
Peptides
41 Citations (Scopus)

Periostin promotes the generation of fibrous membranes in proliferative vitreoretinopathy Keijiro Ishikawa1

Yoshida, S., Nakao, S., Nakama, T., Kita, T., Asato, R., Sassa, Y., Arita, R., Miyazaki, M., Enaida, H., Oshima, Y., Murakami, N., Niiro, H., Ono, J., Matsuda, A., Goto, Y., Akashi, K., Izuhara, K., Kudo, A., Kono, T., Hafezi-Moghadam, A. & 1 others, Ishibashi, T., Jan 2014, In : FASEB Journal. 28, 1, p. 131-142 12 p.

Research output: Contribution to journalArticle

Fibrous membranes
Proliferative Vitreoretinopathy
Retinal Pigments
Membranes
Adhesion
1 Citation (Scopus)

Perioperative blood pressure variability in the treated hypertensive patients

Kiyohara, K., Oniki, H., Tsuchihashi, T. & Matsumura, K., Jun 26 2013, In : Clinical and Experimental Hypertension. 35, 4, p. 291-294 4 p.

Research output: Contribution to journalArticle

Blood Pressure
Angiotensin Receptor Antagonists
Angiotensin-Converting Enzyme Inhibitors
Gastrectomy
Body Weight
2 Citations (Scopus)

Periodontitis Is Associated with Chronic Obstructive Pulmonary Disease

Takeuchi, K., Matsumoto, K., Furuta, M., Fukuyama, S., Takeshita, T., Ogata, H., Suma, S., Shibata, Y., Shimazaki, Y., Hata, J., Ninomiya, T., Nakanishi, Y., Inoue, H. & Yamashita, Y., May 1 2019, In : Journal of Dental Research. 98, 5, p. 534-540 7 p.

Research output: Contribution to journalArticle

Periodontitis
Chronic Obstructive Pulmonary Disease
Vital Capacity
Forced Expiratory Volume
Confidence Intervals
1 Citation (Scopus)

Periodontal status and lung function decline in the community: the Hisayama study

Takeuchi, K., Matsumoto, K., Furuta, M., Fukuyama, S., Takeshita, T., Ogata, H., Suma, S., Shibata, Y., Shimazaki, Y., Hata, J., Ninomiya, T., Nakanishi, Y., Inoue, H. & Yamashita, Y., Dec 1 2018, In : Scientific reports. 8, 1, 13354.

Research output: Contribution to journalArticle

Lung
Odds Ratio
Tooth
Independent Living
Spirometry
2 Citations (Scopus)
Sleep
Parenting
Mothers
Confidence Intervals
Parents
60 Citations (Scopus)

PDGF receptor β signaling in pericytes following ischemic brain injury

Arimura, K., Ago, T., Kamouchi, M., Nakamura, K., Ishitsuka, K., Kuroda, J., Sugimori, H., Ooboshi, H., Sasaki, T. & Kitazono, T., Feb 2012, In : Current Neurovascular Research. 9, 1, p. 1-9 9 p.

Research output: Contribution to journalArticle

Platelet-Derived Growth Factor Receptors
Pericytes
Proto-Oncogene Proteins c-sis
Brain Injuries
Brain
1 Citation (Scopus)

Patterns of Japanese Diet and Risk of Dementia

Ninomiya, T., Jun 22 2015, In : Current Nutrition Reports. 4, 2, p. 136-142 7 p., 4.

Research output: Contribution to journalReview article

dementia
Dementia
Diet
diet
dairy products
5 Citations (Scopus)
Exercise
Population
Independent Living
Body Mass Index
Age Groups
12 Citations (Scopus)

Patient-Reported Outcome Measures-What Data Do We Really Need?

Lyman, S. & Hidaka, C., Jun 1 2016, In : Journal of Arthroplasty. 31, 6, p. 1144-1147 4 p.

Research output: Contribution to journalArticle

Centers for Medicare and Medicaid Services (U.S.)
Replacement Arthroplasties
Orthopedic Procedures
Knee Injuries
Knee Replacement Arthroplasties
48 Citations (Scopus)

Patient-reported outcome measures in arthroplasty registries: Report of the Patient-Reported Outcome Measures Working Group of the International Society of Arthroplasty Registries: Part I. Overview and rationale for patient-reported outcome measures

Rolfson, O., Eresian Chenok, K., Bohm, E., Lübbeke, A., Denissen, G., Dunn, J., Lyman, S., Franklin, P., Dunbar, M., Overgaard, S., Garellick, G. & Dawson, J., Jun 15 2016, In : Acta Orthopaedica. 87, p. 3-8 6 p.

Research output: Contribution to journalArticle

Arthroplasty
Registries
Health Surveys
Hip
Knee Replacement Arthroplasties
59 Citations (Scopus)

Patient-reported outcome measures in arthroplasty registries: Report of the Patient-Reported Outcome Measures Working Group of the International Society of Arthroplasty RegistriesPart II. Recommendations for selection, administration, and analysis

Rolfson, O., Bohm, E., Franklin, P., Lyman, S., Denissen, G., Dawson, J., Dunn, J., Eresian Chenok, K., Dunbar, M., Overgaard, S., Garellick, G. & Lübbeke, A., Jun 15 2016, In : Acta Orthopaedica. 87, p. 9-23 15 p.

Research output: Contribution to journalArticle

Arthroplasty
Registries
Risk Adjustment
Hip
Pain
4 Citations (Scopus)
Surgical Wound Infection
Odds Ratio
Appendectomy
Cholecystectomy
Cross Infection

Patient Factors Affecting Emergency Department Utilization and Hospital Readmission Rates after Primary Anterior Cervical Discectomy and Fusion: A Review of 41,813 cases

Sheha, E. D., Salzmann, S. N., Khormaee, S., Yang, J., Girardi, F. P., Cammisa, F. P., Sama, A. A., Lyman, S. & Hughes, A. P., Aug 1 2019, In : Spine. 44, 15, p. 1078-1086 9 p.

Research output: Contribution to journalArticle

Patient Readmission
Diskectomy
Hospital Emergency Service
Length of Stay
Insurance
68 Citations (Scopus)

Pathophysiological roles of NADPH oxidase/Nox family proteins in the vascular system review and perspective

Ago, T., Kuroda, J., Kamouchi, M., Sadoshima, J. & Kitazono, T., Aug 1 2011, In : Circulation Journal. 75, 8, p. 1791-1800 10 p.

Research output: Contribution to journalReview article

NADPH Oxidase
Vascular Diseases
Blood Vessels
Reperfusion Injury
Reactive Oxygen Species
102 Citations (Scopus)

Pathological neovascularization is reduced by inactivation of ADAM17 in endothelial cells but not in pericytes

Weskamp, G., Mendelson, K., Swendeman, S., Le Gall, S., Ma, Y., Lyman, S., Hinoki, A., Eguchi, S., Guaiquil, V., Horiuchi, K. & Blobel, C. P., Mar 19 2010, In : Circulation research. 106, 5, p. 932-940 9 p.

Research output: Contribution to journalArticle

Pathologic Neovascularization
Disintegrins
Pericytes
Metalloproteases
Endothelial Cells
1 Citation (Scopus)

Pathogenetic mechanism of brain infarction

Kitazono, T., Apr 1 2016, In : Nihon rinsho. Japanese journal of clinical medicine. 74, 4, p. 546-548 3 p.

Research output: Contribution to journalArticle

Intracranial Arteriosclerosis
Brain Infarction
Cerebral Infarction
Atherosclerotic Plaques
Diabetes Complications
12 Citations (Scopus)
Chronic Pain
Mothers
Population
Odds Ratio
Object Attachment
5 Citations (Scopus)

PARK16 polymorphisms, interaction with smoking, and sporadic Parkinson's disease in Japan

Fukuoka Kinki Parkinson's Disease Study Group, Mar 15 2016, In : Journal of the Neurological Sciences. 362, p. 47-52 6 p.

Research output: Contribution to journalArticle

Single Nucleotide Polymorphism
Parkinson Disease
Japan
Smoking
Genotype

Paradoxical Brain Embolism in Elderly Subjects with Small Atrial Septal Defects

Kitamura, T., Arakawa, S., Murao, K., Kitazono, T. & Ago, T., Jul 2018, In : Journal of Stroke and Cerebrovascular Diseases. 27, 7, p. 1987-1991 5 p.

Research output: Contribution to journalArticle

Paradoxical Embolism
Intracranial Embolism
Atrial Heart Septal Defects
Stroke
Valsalva Maneuver
10 Citations (Scopus)

p40phox as an alternative organizer to p47phox in Nox2 activation: A new mechanism involving an interaction with p22phox

Tamura, M., Shiozaki, I., Ono, S., Miyano, K., Kunihiro, S. & Sasaki, T., Sep 18 2007, In : FEBS Letters. 581, 23, p. 4533-4538 6 p.

Research output: Contribution to journalArticle

Chemical activation
Far-Western Blotting
src Homology Domains
Cell-Free System
NADPH Oxidase
44 Citations (Scopus)

Oxaliplatin induces mitotic catastrophe and apoptosis in esophageal cancer cells

Ngan, C. Y., Yamamoto, H., Takagi, A., Fujie, Y., Takemasa, I., Ikeda, M., Takahashi-Yanaga, F., Sasaguri, T., Sekimoto, M., Matsuura, N. & Monden, M., Jan 1 2008, In : Cancer Science. 99, 1, p. 129-139 11 p.

Research output: Contribution to journalArticle

oxaliplatin
Esophageal Neoplasms
Apoptosis
Down-Regulation
Cell Line
75 Citations (Scopus)

Overview of the BioBank Japan Project: Study design and profile

Biobank Japan Cooperative Hospital Group, Jan 1 2017, In : Journal of epidemiology. 27, 3, p. S2-S8

Research output: Contribution to journalArticle

Japan
Precision Medicine
Survival
Medical Records
Registries
23 Citations (Scopus)

Overview of BioBank Japan follow-up data in 32 diseases

Biobank Japan Cooperative Hospital Group, Jan 1 2017, In : Journal of epidemiology. 27, 3, p. S22-S28

Research output: Contribution to journalArticle

Japan
Survival Rate
Survival Analysis
Survival
Cause of Death
3 Citations (Scopus)

Overexpression of mth1 and ogg1 proteins in ulcerative colitis-associated carcinogenesis

Kumagae, Y., Hirahashi, M., Takizawa, K., Yamamoto, H., Gushima, M., Esaki, M., Matsumoto, T., Nakamura, M., Kitazono, T. & Oda, Y., Aug 2018, In : Oncology Letters. 16, 2, p. 1765-1776 12 p.

Research output: Contribution to journalArticle

Ulcerative Colitis
Carcinogenesis
Neoplasms
Proteins
ras Proteins

Outcomes of lumbar decompression surgery in patients with diffuse idiopathic skeletal hyperostosis (DISH)

Otsuki, B., Fujibayashi, S., Tanida, S., Shimizu, T., Lyman, S. & Matsuda, S., Nov 2019, In : Journal of Orthopaedic Science. 24, 6, p. 957-962 6 p.

Research output: Contribution to journalArticle

Diffuse Idiopathic Skeletal Hyperostosis
Decompression
Reoperation
Osteogenesis
Spine
1 Citation (Scopus)

Outcomes associated with under-dosing of rivaroxaban for management of non-valvular atrial fibrillation in real-world Japanese clinical settings

Ikeda, T., Ogawa, S., Kitazono, T., Nakagawara, J., Minematsu, K., Miyamoto, S., Murakawa, Y., Iwashiro, S., Kidani, Y., Okayama, Y., Sunaya, T., Sato, S. & Yamanaka, S., Nov 1 2019, In : Journal of Thrombosis and Thrombolysis. 48, 4, p. 653-660 8 p.

Research output: Contribution to journalArticle

Open Access
Atrial Fibrillation
Hemorrhage
Embolism
Rivaroxaban
Nervous System
9 Citations (Scopus)

Outcomes associated with carotid pseudo-occlusion

Ogata, T., Yasaka, M., Kanazawa, Y., Wakugawa, Y., Inoue, T., Yasumori, K., Kitazono, T. & Okada, Y., Apr 1 2011, In : Cerebrovascular Diseases. 31, 5, p. 494-498 5 p.

Research output: Contribution to journalArticle

Carotid Stenosis
Myocardial Infarction
Cerebral Angiography
Peripheral Arterial Disease
Kaplan-Meier Estimate
6 Citations (Scopus)

Outcome prediction in acute stroke patients by continuous glucose monitoring

Wada, S., Yoshimura, S., Inoue, M., Matsuki, T., Arihiro, S., Koga, M., Kitazono, T., Makino, H., Hosoda, K., Ihara, M. & Toyoda, K., Apr 17 2018, In : Journal of the American Heart Association. 7, 8, e008744.

Research output: Contribution to journalArticle

Blood Glucose
Stroke
Glucose
Area Under Curve
Cerebral Hemorrhage
2 Citations (Scopus)

Orthostatic hypotension predicts a poor prognosis in elderly people with dementia

Oishi, E., Sakata, S., Tsuchihashi, T., Tominaga, M. & Fujii, K., Jan 1 2016, In : Internal Medicine. 55, 15, p. 1947-1952 6 p.

Research output: Contribution to journalArticle

Orthostatic Hypotension
Dementia
Blood Pressure
Demography
Frail Elderly
1 Citation (Scopus)

Orthopaedic registries with patient-reported outcome measures

Wilson, I., Bohm, E., Lübbeke, A., Lyman, S., Overgaard, S., Rolfson, O., W-Dahl, A., Wilkinson, M. & Dunbar, M., Jun 1 2019, In : EFORT Open Reviews. 4, 6, p. 357-367 11 p.

Research output: Contribution to journalArticle

Open Access
Orthopedics
Registries
Arthroplasty
Quality of Life
Pain
3 Citations (Scopus)

Organ-dependent T-cell subset requirement in defense against virus in mice acutely and systemically infected with murine cytomegalovirus

Kimura, G., Takimoro, H., Yoshida, H., Ninomiya, T., Nukina, H., Ohtsu, M. & Nomoto, K., Jan 1 2000, In : Biomedical Research. 21, 2, p. 111-115 5 p.

Research output: Contribution to journalArticle

Muromegalovirus
T-cells
T-Lymphocyte Subsets
Viruses
Spleen
6 Citations (Scopus)

Oral mycobiome in community-dwelling elderly and its relation to oral and general health conditions

Zakaria, M. N., Furuta, M., Takeshita, T., Shibata, Y., Sundari, R., Eshima, N., Ninomiya, T. & Yamashita, Y., Oct 2017, In : Oral Diseases. 23, 7, p. 973-982 10 p.

Research output: Contribution to journalArticle

Independent Living
Oral Health
Body Mass Index
Candida albicans
Fungi
19 Citations (Scopus)

Optimal cutoff value of the serum pepsinogen level for prediction of gastric cancer incidence: The Hisayama Study

Shikata, K., Ninomiya, T., Yonemoto, K., Ikeda, F., Hata, J., Doi, Y., Fukuhara, M., Matsumoto, T., Iida, M., Kitazono, T. & Kiyohara, Y., Jun 1 2012, In : Scandinavian Journal of Gastroenterology. 47, 6, p. 669-675 7 p.

Research output: Contribution to journalArticle

Pepsinogen A
Stomach Neoplasms
Incidence
Serum
Pepsinogen C

Optimal anticoagulation for patients with atrial fibrillation — Benefits for reducing stroke severity —

Kamouchi, M., Jan 1 2017, In : Circulation Journal. 81, 3, p. 306-307 2 p.

Research output: Contribution to journalEditorial

Atrial Fibrillation
Stroke
86 Citations (Scopus)

Opposing actions of angiotensin-(1-7) and angiotensin II in the brain of transgenic hypertensive rats

Moriguchi, A., Tallant, E. A., Matsumura, K., Reilly, T. M., Walton, H., Ganten, D. & Ferrario, C. M., Jun 1995, In : Hypertension. 25, 6, p. 1260-1265 6 p.

Research output: Contribution to journalArticle

Transgenic Rats
Angiotensin II
Antibodies
Brain
Lisinopril
1 Citation (Scopus)

Opioids modulate cardiovascular and neurohormonal responses to intracerebroventricular injection of endothelin in conscious rabbits

Matsumura, K., Abe, I., Tsuchihashi, T., Tominaga, M., Kobayashi, K. & Fujishima, M., Dec 1 1990, In : Therapeutic Research. 11, 12, p. 105-110 6 p.

Research output: Contribution to journalArticle

Endothelins
Opioid Analgesics
Rabbits
Injections
24 Citations (Scopus)

Onset of spermatogenesis is accelerated by gestational administration of 1,2,3,4,6,7-hexachlorinated naphthalene in male rat offspring

Omura, M., Masuda, Y., Hirata, M., Tanaka, A., Makita, Y., Ogata, R. & Inoue, N., Jan 1 2000, In : Environmental Health Perspectives. 108, 6, p. 539-544 6 p.

Research output: Contribution to journalArticle

Spermatogenesis
Sperm Count
Follicle Stimulating Hormone
Luteinizing Hormone
Sexual Maturation

Onset of reversible flaccid quadriplegia during treatment of thyrotoxic crisis

Mizokam, T., Fukui, T., Imoto, H., Fujii, H., Sato, Y., Nunoi, K. & Okamura, K., Jan 1 2015, In : Internal Medicine. 54, 4, p. 421-425 5 p.

Research output: Contribution to journalArticle

Thyroid Crisis
Quadriplegia
Antithyroid Agents
Thyrotoxicosis
Multiple Organ Failure
22 Citations (Scopus)

One- versus two-incision technique for distal biceps tendon repair

Johnson, T. S., Johnson, D. C., Shindle, M. K., Allen, A. A., Weiland, A. J., Cavanaugh, J., Noonan, D. & Lyman, S., Sep 1 2008, In : HSS Journal. 4, 2, p. 117-122 6 p.

Research output: Contribution to journalArticle

Tendons
Supination
Physical Examination
Surgeons
7 Citations (Scopus)

Occupational risk factors for Parkinson's disease: A case-control study in Japan

Tanaka, K., Miyake, Y., Fukushima, W., Sasaki, S., Kiyohara, C., Tsuboi, Y., Yamada, T., Oeda, T., Miki, T., Kawamura, N., Sakae, N., Fukuyama, H., Hirota, Y. & Nagai, M., Jul 7 2011, In : BMC neurology. 11, 83.

Research output: Contribution to journalArticle

Parkinson Disease
Case-Control Studies
Japan
Occupations
Odds Ratio
9 Citations (Scopus)
Urinary Bladder Neck Obstruction
rho-Associated Kinases
Carbachol
Protein Kinase C
Smooth Muscle
Open Access
Diabetes Mellitus
Insulin Resistance
Population
Homeostasis
Energy Intake
97 Citations (Scopus)

Obesity, weight gain and risk of colon adenomas in Japanese men

Kono, S., Handa, K., Hayabuchi, H., Kiyohara, C., Inoue, H., Marugame, T., Shinomiya, S., Hamada, H., Onuma, K. & Koga, H., Aug 1999, In : Japanese Journal of Cancer Research. 90, 8, p. 805-811 7 p.

Research output: Contribution to journalArticle

Adenoma
Weight Gain
Colon
Obesity
Waist-Hip Ratio
Open Access
Brain Natriuretic Peptide
Dementia
Population
Serum
Alzheimer Disease
22 Citations (Scopus)

N-terminal pro-brain natriuretic peptide and risk of cardiovascular events in a Japanese community: The hisayama study

Doi, Y., Ninomiya, T., Hata, J., Hirakawa, Y., Mukai, N., Ikeda, F., Fukuhara, M., Iwase, M. & Kiyohara, Y., Dec 1 2011, In : Arteriosclerosis, thrombosis, and vascular biology. 31, 12, p. 2997-3003 7 p.

Research output: Contribution to journalArticle

Brain Natriuretic Peptide
Cardiovascular Diseases
Stroke
Independent Living
Natriuretic Peptides