Department of Medical Education

Research Output 1983 2020

The Nox family of NADPH oxidases that deliberately produce reactive oxygen species

Sumimoto, H., Minakami, R. & Miyano, K., Dec 2010, Free Radical Biology in Digestive Diseases. Vol. 29. p. 23-34 12 p. (Frontiers of Gastrointestinal Research; vol. 29).

Research output: Chapter in Book/Report/Conference proceedingChapter

NADPH Oxidase
Reactive Oxygen Species
Oxidoreductases
EF Hand Motifs
Proteins
1 Citation (Scopus)

The nox family of NADPH oxidases that deliberately produce reactive oxygen species

Sumimoto, H., Minakami, R. & Miyano, K., Dec 21 2010, Free Radical Biology in Digestive Diseases. S. Karger AG, Vol. 29. p. 23-34 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

NADPH Oxidase
oxidase
Reactive Oxygen Species
Oxidoreductases
oxygen
48 Citations (Scopus)

The NADPH oxidase Nox4 and aging in the heart

Ago, T., Matsushima, S., Kuroda, J., Zablocki, D., Kitazono, T. & Sadoshima, J., Dec 2010, In : Aging. 2, 12, p. 1012-1016 5 p.

Research output: Contribution to journalArticle

NADPH Oxidase
Oxidative Stress
Mitochondria
Cardiac Myocytes
Intracellular Membranes
131 Citations (Scopus)

The NADPH oxidase Nox3 constitutively produces superoxide in a p22 phox-dependent manner: Its regulation by oxidase organizers and activators

Ueno, N., Takeya, R., Miyano, K., Kikuchi, H. & Sumimoto, H., Jun 17 2005, In : Journal of Biological Chemistry. 280, 24, p. 23328-23339 12 p.

Research output: Contribution to journalArticle

NADPH Oxidase
Superoxides
Oxidoreductases
Gravity Sensing
Acetates

The long-term follow-up of patients with thionamidetreated graves’ hyperthyroidism

Bandai, S., Okamura, K., Fujikawa, M., Sato, K., Ikenoue, H. & Kitazono, T., Jan 1 2019, In : Endocrine Journal. 66, 6, p. 535-545 11 p.

Research output: Contribution to journalArticle

Open Access
Hyperthyroidism
Immunoglobulins
Hypothyroidism
Goiter
Thyroid Gland
29 Citations (Scopus)

The long-term association between physical activity and risk of dementia in the community: the Hisayama Study

Kishimoto, H., Ohara, T., Hata, J., Ninomiya, T., Yoshida, D., Mukai, N., Nagata, M., Ikeda, F., Fukuhara, M., Kumagai, S., Kanba, S., Kitazono, T. & Kiyohara, Y., Mar 1 2016, In : European Journal of Epidemiology. 31, 3, p. 267-274 8 p.

Research output: Contribution to journalArticle

Dementia
Exercise
Alzheimer Disease
Vascular Dementia
Independent Living
9 Citations (Scopus)

The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2019)

Umemura, S., Arima, H., Arima, S., Asayama, K., Dohi, Y., Hirooka, Y., Horio, T., Hoshide, S., Ikeda, S., Ishimitsu, T., Ito, M., Ito, S., Iwashima, Y., Kai, H., Kamide, K., Kanno, Y., Kashihara, N., Kawano, Y., Kikuchi, T., Kitamura, K. & 25 others, Kitazono, T., Kohara, K., Kudo, M., Kumagai, H., Matsumura, K., Matsuura, H., Miura, K., Mukoyama, M., Nakamura, S., Ohkubo, T., Ohya, Y., Okura, T., Rakugi, H., Saitoh, S., Shibata, H., Shimosawa, T., Suzuki, H., Takahashi, S., Tamura, K., Tomiyama, H., Tsuchihashi, T., Ueda, S., Uehara, Y., Urata, H. & Hirawa, N., Sep 1 2019, In : Hypertension Research. 42, 9, p. 1235-1481 247 p.

Research output: Contribution to journalReview article

Open Access
Guidelines
Hypertension
1 Citation (Scopus)

The isolation of methicillin-resistant Staphylococcus aureus (MRSA) is a predictor for poor prognosis of the elderly patients with bacterial infection

Washio, M., Ishibashi, N., Arai, Y., Kiyohara, C., Tanaka, K., Maeda, M., Fujishima, M. & Okayama, M., Jan 1 2000, In : International Medical Journal. 7, 2, p. 117-120 4 p.

Research output: Contribution to journalArticle

Methicillin-Resistant Staphylococcus aureus
Bacterial Infections
Geriatrics
Patient Isolation
Hypoalbuminemia
15 Citations (Scopus)

The involvement of aldosterone in cyclic stretch-mediated activation of NADPH oxidase in vascular smooth muscle cells

Ohmine, T., Miwa, Y., Takahashi-Yanaga, F., Morimoto, S., Maehara, Y. & Sasaguri, T., Aug 13 2009, In : Hypertension Research. 32, 8, p. 690-699 10 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP11B2
Aldosterone
NADP
Vascular Smooth Muscle
Smooth Muscle Myocytes
24 Citations (Scopus)

The insert region of the Rac GTPases is dispensable for activation of superoxide-producing NADPH oxidases

Miyano, K., Koga, H., Minakami, R. & Sumimoto, H., Sep 1 2009, In : Biochemical Journal. 422, 2, p. 373-382 10 p.

Research output: Contribution to journalArticle

NADPH Oxidase
GTP Phosphohydrolases
Superoxides
Chemical activation
Oxidoreductases
7 Citations (Scopus)

The influence of CYP2C19 polymorphisms on exacerbating effect of rabeprazole in celecoxib-induced small bowel injury

Nuki, Y., Umeno, J., Washio, E., Maehata, Y., Hirano, A., Miyazaki, M., Kobayashi, H., Kitazono, T., Matsumoto, T. & Esaki, M., Aug 2017, In : Alimentary Pharmacology and Therapeutics. 46, 3, p. 331-336 6 p.

Research output: Contribution to journalArticle

Celecoxib
Rabeprazole
Cytochrome P-450 Enzyme System
Proton Pump Inhibitors
Wounds and Injuries
7 Citations (Scopus)

The influence of chronic antihypertensive treatment on the central pressor response in SHR

Lin, Y., Tsuchihashi, T., Kagiyama, S., Matsumura, K. & Abe, I., May 8 2001, In : Hypertension Research. 24, 2, p. 173-178 6 p.

Research output: Contribution to journalArticle

Antihypertensive Agents
Enalapril
Cerebrum
Peptidyl-Dipeptidase A
Catecholamines
32 Citations (Scopus)

The improvement of renal survival with steroid pulse therapy in IgA nephropathy

Katafuchi, R., Ninomiya, T., Mizumasa, T., Ikeda, K., Kumagai, H., Nagata, M. & Hirakata, H., Dec 2008, In : Nephrology Dialysis Transplantation. 23, 12, p. 3915-3920 6 p.

Research output: Contribution to journalArticle

Immunoglobulin A
Steroids
Kidney
IGA Glomerulonephritis
Therapeutics
37 Citations (Scopus)

The Impacts of Albuminuria and Low eGFR on the Risk of Cardiovascular Death, All-Cause Mortality, and Renal Events in Diabetic Patients: Meta-Analysis

Toyama, T., Furuichi, K., Ninomiya, T., Shimizu, M., Hara, A., Iwata, Y., Kaneko, S. & Wada, T., Aug 30 2013, In : PloS one. 8, 8, e71810.

Research output: Contribution to journalArticle

Albuminuria
glomerular filtration rate
Glomerular Filtration Rate
meta-analysis
relative risk
16 Citations (Scopus)

The impact of predisposing factors on long-term outcome after stroke in diabetic patients: The Fukuoka Stroke Registry

Kuwashiro, T., Sugimori, H., Ago, T., Kuroda, J., Kamouchi, M. & Kitazono, T., Jun 1 2013, In : European Journal of Neurology. 20, 6, p. 921-927 7 p.

Research output: Contribution to journalArticle

Causality
Registries
Stroke
Diabetes Mellitus
Odds Ratio
3 Citations (Scopus)

The gene-treatment interaction of paraoxonase-1 gene polymorphism and statin therapy on insulin secretion in Japanese patients with type 2 diabetes: Fukuoka diabetes registry

Sumi, A., Nakamura, U., Iwase, M., Fujii, H., Ohkuma, T., Ide, H., Jodai-Kitamura, T., Komorita, Y., Yoshinari, M., Hirakawa, Y., Hirano, A., Kubo, M. & Kitazono, T., Dec 12 2017, In : BMC Medical Genetics. 18, 1, 146.

Research output: Contribution to journalArticle

Aryldialkylphosphatase
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Type 2 Diabetes Mellitus
Registries
Insulin

The Fukuoka Kidney disease Registry (FKR) Study: design and methods

Fukuoka Kidney disease Registry (FKR) Study Collaboration Group, Jun 1 2017, In : Clinical and Experimental Nephrology. 21, 3, p. 465-473 9 p.

Research output: Contribution to journalArticle

Kidney Diseases
Chronic Renal Insufficiency
Registries
Genetic Predisposition to Disease
Chronic Kidney Failure
11 Citations (Scopus)

The factors associated with a functional outcome after ischemic stroke in diabetic patients: The Fukuoka Stroke Registry

Kuwashiro, T., Kamouchi, M., Ago, T., Hata, J., Sugimori, H. & Kitazono, T., Feb 15 2012, In : Journal of the Neurological Sciences. 313, 1-2, p. 110-114 5 p.

Research output: Contribution to journalArticle

Registries
Stroke
Angiotensin Receptor Antagonists
Odds Ratio
Proteinuria
10 Citations (Scopus)
Habits
Japan
Smoking
Students
Tobacco Products
13 Citations (Scopus)

The EXPAND study: Efficacy and safety of rivaroxaban in Japanese patients with non-valvular atrial fibrillation

Shimokawa, H., Yamashita, T., Uchiyama, S., Kitazono, T., Shimizu, W., Ikeda, T., Kamouchi, M., Kaikita, K., Fukuda, K., Origasa, H., Sakuma, I., Saku, K., Okumura, Y., Nakamura, Y., Morimoto, H., Matsumoto, N., Tsuchida, A., Ako, J., Sugishita, N., Shimizu, S. & 2 others, Atarashi, H. & Inoue, H., May 1 2018, In : International Journal of Cardiology. 258, p. 126-132 7 p.

Research output: Contribution to journalArticle

Atrial Fibrillation
Embolism
Hemorrhage
Safety
Stroke
31 Citations (Scopus)

The efficacy of a thrombin-based hemostatic agent in unilateral total knee arthroplasty: A randomized controlled trial

Kim, H. J., Fraser, M. R., Kahn, B., Lyman, S. & Figgie, M. P., Jul 3 2012, In : Journal of Bone and Joint Surgery - Series A. 94, 13, p. 1160-1165 6 p.

Research output: Contribution to journalArticle

Knee Replacement Arthroplasties
Hemostatics
Thrombin
Randomized Controlled Trials
Knee
3 Citations (Scopus)

The Effects of Diagnostic Definitions in Claims Data on Healthcare Cost Estimates: Evidence from a Large-Scale Panel Data Analysis of Diabetes Care in Japan

Fukuda, H., Ikeda, S., Shiroiwa, T. & Fukuda, T., Oct 1 2016, In : PharmacoEconomics. 34, 10, p. 1005-1014 10 p.

Research output: Contribution to journalArticle

Health Care Costs
Japan
Confidence Intervals
Diabetes Complications
Costs and Cost Analysis
7 Citations (Scopus)

The effect of renin–angiotensin system blockade on the incidence of end-stage renal disease in IgA nephropathy

Tanaka, S., Ninomiya, T., Katafuchi, R., Masutani, K., Nagata, M., Tsuchimoto, A., Hirakata, H., Kitazono, T. & Tsuruya, K., Oct 1 2016, In : Clinical and Experimental Nephrology. 20, 5, p. 689-698 10 p.

Research output: Contribution to journalArticle

Immunoglobulin A
Chronic Kidney Failure
Incidence
Propensity Score
Therapeutics
15 Citations (Scopus)

The effect of metabolic syndrome defined by various criteria on the development of ischemic stroke subtypes in a general Japanese population

Hata, J., Doi, Y., Ninomiya, T., Tanizaki, Y., Yonemoto, K., Fukuhara, M., Kubo, M., Kitazono, T., Iida, M. & Kiyohara, Y., May 1 2010, In : Atherosclerosis. 210, 1, p. 249-255 7 p.

Research output: Contribution to journalArticle

Stroke
Population
Waist Circumference
Confidence Intervals
Infarction
66 Citations (Scopus)

The effect of folic acid based homocysteine lowering on cardiovascular events in people with kidney disease: Systematic review and meta-analysis

Jardine, M. J., Kang, A., Zoungas, S., Navaneethan, S. D., Ninomiya, T., Nigwekar, S. U., Gallagher, M. P., Cass, A., Strippoli, G. & Perkovic, V., Jun 30 2012, In : BMJ (Online). 344, 7863, e3533.

Research output: Contribution to journalReview article

Kidney Diseases
Homocysteine
Folic Acid
Meta-Analysis
Chronic Renal Insufficiency
15 Citations (Scopus)

The domain organization of p67, a protein required for activation of the superoxide-producing NADPH oxidase in phagocytes

Yuzawa, S., Miyano, K., Honbou, K., Inagaki, F. & Sumimoto, H., Oct 1 2009, In : Journal of Innate Immunity. 1, 6, p. 543-555 13 p.

Research output: Contribution to journalArticle

src Homology Domains
NADPH Oxidase
Phagocytes
Superoxides
Oxidoreductases
6 Citations (Scopus)
Surgical Wound Infection
Statistical Models
Japan
Infection
Cross Infection
73 Citations (Scopus)

The developmental program of human dendritic cells is operated independently of conventional myeloid and lymphoid pathways

Ishikawa, F., Niiro, H., Iino, T., Yoshida, S., Saito, N., Onohara, S., Miyamoto, T., Minagawa, H., Fujii, S. I., Shultz, L. D., Harada, M. & Akashi, K., Nov 15 2007, In : Blood. 110, 10, p. 3591-3600 10 p.

Research output: Contribution to journalArticle

Dendritic Cells
Genes
Lymphoid Progenitor Cells
Myeloid Progenitor Cells
Assays
33 Citations (Scopus)

The cytotoxic effects of certolizumab pegol and golimumab mediated by transmembrane tumor necrosis factorα

Ueda, N., Tsukamoto, H., Mitoma, H., Ayano, M., Tanaka, A., Ohta, S. I., Inoue, Y., Arinobu, Y., Niiro, H., Akashi, K. & Horiuchi, T., May 1 2013, In : Inflammatory bowel diseases. 19, 6, p. 1224-1231 8 p.

Research output: Contribution to journalArticle

Antibody-Dependent Cell Cytotoxicity
Tumor Necrosis Factor-alpha
Crohn Disease
Jurkat Cells
Tumor Necrosis Factor Receptors
9 Citations (Scopus)

The contribution of inflammation to the development of hypertension mediated by increased arterial stiffness

Tomiyama, H., Shiina, K., Matsumoto-Nakano, C., Ninomiya, T., Komatsu, S., Kimura, K., Chikamori, T. & Yamashina, A., Jul 1 2017, In : Journal of the American Heart Association. 6, 7, e005729.

Research output: Contribution to journalArticle

Vascular Stiffness
C-Reactive Protein
Pulse Wave Analysis
Hypertension
Inflammation
19 Citations (Scopus)

The construction of risk prediction models using GWAS data and its application to a type 2 diabetes prospective cohort

Shigemizu, D., Abe, T., Morizono, T., Johnson, T. A., Boroevich, K. A., Hirakawa, Y., Ninomiya, T., Kiyohara, Y., Kubo, M., Nakamura, Y., Maeda, S. & Tsunoda, T., Mar 20 2014, In : PloS one. 9, 3, e92549.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Medical problems
noninsulin-dependent diabetes mellitus
Type 2 Diabetes Mellitus
Genes
53 Citations (Scopus)

The combination of polymorphisms within interferon-γ receptor I and receptor 2 associated with the risk of systemic lupus erythematosus

Nakashima, H., Inoue, H., Akahoshi, M., Tanaka, Y., Yamaoka, K., Ogami, E., Nagano, S., Arinobu, Y., Niiro, H., Otsuka, T. & Niho, Y., Jun 18 1999, In : FEBS Letters. 453, 1-2, p. 187-190 4 p.

Research output: Contribution to journalArticle

Interferon Receptors
Polymorphism
Systemic Lupus Erythematosus
Amino Acids
Genotype
8 Citations (Scopus)

The clinical utility of serum tartrate-resistant acid phosphatase 5b in the assessment of bone resorption in patients on peritoneal dialysis

Yamada, S., Tsuruya, K., Yoshida, H., Taniguchi, M., Haruyama, N., Tanaka, S., Eriguchi, M., Nakano, T. & Kitazono, T., Jun 1 2013, In : Clinical Endocrinology. 78, 6, p. 844-851 8 p.

Research output: Contribution to journalArticle

Peritoneal Dialysis
Bone Resorption
Bone and Bones
Serum
Alkaline Phosphatase
9 Citations (Scopus)

The characteristics of a good clinical teacher as perceived by resident physicians in Japan: A qualitative study

Kikukawa, M., Nabeta, H., Ono, M., Emura, S., Oda, Y., Koizumi, S. & Sakemi, T., Aug 7 2013, In : BMC Medical Education. 13, 1, 100.

Research output: Contribution to journalArticle

Japan
physician
resident
teacher
educational system
7 Citations (Scopus)

The Case Fatality Rate of Methicillin-Resistant Staphylococcus aureus (MRSA) Infection among the Elderly in a Geriatric Hospital and Their Risk Factors

Washio, M., Kiyohara, C., Hamada, T., Miyake, Y., Arai, Y. & Okayama, M., Jan 1 1997, In : Tohoku Journal of Experimental Medicine. 183, 1, p. 75-82 8 p.

Research output: Contribution to journalArticle

Geriatrics
Methicillin
Methicillin-Resistant Staphylococcus aureus
Mortality
Hypoalbuminemia
47 Citations (Scopus)

The association between hospital volume and total shoulder arthroplasty outcomes

Lyman, S., Jones, E. C., Bach, P. B., Peterson, M. G. E. & Marx, R. G., Mar 2005, In : Clinical orthopaedics and related research. 432, p. 132-137 6 p.

Research output: Contribution to journalArticle

Arthroplasty
Hospital Costs
Length of Stay
High-Volume Hospitals
Patient Readmission
49 Citations (Scopus)

The antioxidant tempol ameliorates arterial medial calcification in uremic rats: Important role of oxidative stress in the pathogenesis of vascular calcification in chronic kidney disease

Yamada, S., Taniguchi, M., Tokumoto, M., Toyonaga, J., Fujisaki, K., Suehiro, T., Noguchi, H., Iida, M., Tsuruya, K. & Kitazono, T., Jan 30 2012, In : Journal of Bone and Mineral Research. 27, 2, p. 474-485 12 p.

Research output: Contribution to journalArticle

Vascular Calcification
Chronic Renal Insufficiency
Oxidative Stress
Antioxidants
Uremia
182 Citations (Scopus)

The age-specific quantitative effects of metabolic risk factors on cardiovascular diseases and diabetes: A pooled analysis

Emerging Risk Factor Collaboration (ERFC), Global Burden Of Metabolic Risk Factors Of Chronic Diseases Collaborating Group, Asia-Pacific Cohort Studies Collaboration (APCSC), Prospective Studies Collaboration (PSC) & Diabetes Epidemiology Collaborative Analysis Of Diagnostic Criteria In Europe (DECODE), Jul 30 2013, In : PloS one. 8, 7, e65174.

Research output: Contribution to journalArticle

Medical problems
cardiovascular diseases
diabetes
Cardiovascular Diseases
risk factors
3 Citations (Scopus)

The acute toxicity of allyl chloride by subcutaneous injection in mice.

Omura, M., Itonaga, Y., Komatsu, H., Mangen, Z., Hirata, M., Tanaka, A. & Inoue, N., Oct 1993, In : Fukuoka igaku zasshi = Hukuoka acta medica. 84, 10, p. 427-432 6 p.

Research output: Contribution to journalArticle

Leydig Cells
Subcutaneous Injections
Necrosis
Kidney Tubules
Inbred ICR Mouse
228 Citations (Scopus)

Th1/Th2 balance of peripheral T helper cells in systemic lupus erythematosus

Akahoshi, M., Nakashima, H., Tanaka, Y., Kohsaka, T., Nagano, S., Ohgami, E., Arinobu, Y., Yamaoka, K., Niiro, H., Shinozaki, M., Hirakata, H., Horiuchi, T., Otsuka, T. & Niho, Y., Aug 1 1999, In : Arthritis and rheumatism. 42, 8, p. 1644-1648 5 p.

Research output: Contribution to journalArticle

Th1-Th2 Balance
Helper-Inducer T-Lymphocytes
Systemic Lupus Erythematosus
Th2 Cells
Lupus Nephritis
49 Citations (Scopus)

Testicular toxicity of gallium arsenide, indium arsenide, and arsenic oxide in rats by repetitive intratracheal instillation

Omura, M., Tanaka, A., Hirata, M., Zhao, M., Makita, Y., Inoue, N., Gotoh, K. & Ishinishi, N., Jul 1996, In : Fundamental and Applied Toxicology. 32, 1, p. 72-78 7 p.

Research output: Contribution to journalArticle

Arsenic
Oxides
Toxicity
Rats
Sperm Count
4 Citations (Scopus)
Antimony Potassium Tartrate
Antimony
Body Weight
Testis
Genitalia
18 Citations (Scopus)

Testicular toxicity evaluation of indium-tin oxide

Omura, M., Tanaka, A., Hirata, M., Inoue, N., Ueno, T., Homma, T. & Sekizawa, K., May 11 2002, In : Journal of Occupational Health. 44, 2, p. 105-107 3 p.

Research output: Contribution to journalArticle

Indium
Toxicity
indium tin oxide
39 Citations (Scopus)

Testicular toxicity evaluation of arsenic-containing binary compound semiconductors, gallium arsenide and indium arsenide, in hamsters

Omura, M., Hirata, M., Tanaka, A., Zhao, M., Makita, Y., Inoue, N., Gotoh, K. & Ishinishi, N., Dec 16 1996, In : Toxicology Letters. 89, 2, p. 123-129 7 p.

Research output: Contribution to journalArticle

Semiconductors
Arsenic
Cricetinae
Toxicity
Semiconductor materials
65 Citations (Scopus)

Ten year recurrence after first ever stroke in a Japanese community: The Hisayama study

Hata, J., Tanizaki, Y., Kiyohara, Y., Kato, I., Kubo, M., Tanaka, K., Okubo, K., Nakamura, H., Oishi, Y., Ibayashi, S. & Iida, M., Mar 1 2005, In : Journal of Neurology, Neurosurgery and Psychiatry. 76, 3, p. 368-372 5 p.

Research output: Contribution to journalArticle

Stroke
Brain Infarction
Recurrence
Subarachnoid Hemorrhage
Intracranial Hemorrhages
16 Citations (Scopus)

Temporal trends in sudden unexpected death in a general population: The hisayama study

Nagata, M., Ninomiya, T., Doi, Y., Hata, J., Ikeda, F., Mukai, N., Tsuruya, K., Oda, Y., Kitazono, T. & Kiyohara, Y., Jun 2013, In : American heart journal. 165, 6, p. 932-938.e1

Research output: Contribution to journalArticle

Sudden Death
Population
Myocardial Ischemia
Autopsy
Cause of Death
2 Citations (Scopus)

Temporal serum creatinine increase and exacerbation of tubulointerstitial inflammation during the first two months in resolving polyomavirus BK nephropathy

Masutani, K., Tsuchimoto, A., Matsukuma, Y., Kurihara, K., Nishiki, T., Kitada, H., Tanaka, M., Kitazono, T. & Tsuruya, K., Jul 1 2015, In : Nephrology. 20, S2, p. 45-50 6 p.

Research output: Contribution to journalArticle

BK Virus
Creatinine
Inflammation
Biopsy
Serum
5 Citations (Scopus)
Secretory Phospholipase A2
Acetylcysteine
Endothelial Cells
Tumor Necrosis Factor-alpha
LDL Lipoproteins
35 Citations (Scopus)
Galectin 1
T-Cell Leukemia
T-Cell Lymphoma
Immunoglobulin M
B-Lymphocytes