Department of Medical Education

Research Output

2005
23 Citations (Scopus)

Elevated C-reactive protein is a predictor of the development of diabetes in a general Japanese population: The Hisayama study

Doi, Y., Kiyohara, Y., Kubo, M., Ninomiya, T., Wakugawa, Y., Yonemoto, K., Iwase, M. & Iida, M., Oct 1 2005, In : Diabetes care. 28, 10, p. 2497-2500 4 p.

Research output: Contribution to journalArticle

100 Citations (Scopus)

Genetic polymorphism of enzymes involved in xenobiotic metabolism and the risk of lung cancer: a review

Kiyohara, C., 2005, Focus on Lung Cancer Research. p. 1-49

Research output: Chapter in Book/Report/Conference proceedingChapter

Graft infection of thoracic aorta due to group C β-hemolytic streptococcus: A case report

Arima, H., Nagata, M., Fujisaki, K., Gushima, M., Matsumura, K., Fujii, K., Tsuchihashi, T., Hirakata, H., Eguchi, T., Moroi, Y., Furue, M., Yasui, H., Tsuneyoshi, M. & Iida, M., Mar 1 2005, In : Angiology. 56, 2, p. 237-241 5 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Increased renal resistive index in atherosclerosis and diabetic nephropathy assessed by Doppler sonography

Ohta, Y., Fujii, K., Arima, H., Matsumura, K., Tsuchihashi, T., Tokumoto, M., Tsuruya, K., Kanai, H., Iwase, M., Hirakata, H. & Iida, M., Oct 2005, In : Journal of hypertension. 23, 10, p. 1905-1911 7 p.

Research output: Contribution to journalArticle

102 Citations (Scopus)

Interleukin-3 (IL-3), IL-4, IL-5

Niiro, H., Jan 1 2005, In : Nippon rinsho. Japanese journal of clinical medicine. 63 Suppl 8, p. 68-71 4 p.

Research output: Contribution to journalReview article

Molecular composition and regulation of the Nox family NAD(P)H oxidases

Sumimoto, H., Miyano, K. & Takeya, R., Dec 9 2005, In : Biochemical and Biophysical Research Communications. 338, 1, p. 677-686 10 p.

Research output: Contribution to journalReview article

230 Citations (Scopus)

Molecular dissection of the interaction between p27 and Kip1 ubiquitylation-promoting complex, the ubiquitin ligase that regulates proteolysis of p27 in G1 phase

Kotoshibai, S., Kamura, T., Hara, T., Ishida, N. & Nakayama, K., May 6 2005, In : Journal of Biological Chemistry. 280, 18, p. 17694-17700 7 p.

Research output: Contribution to journalArticle

67 Citations (Scopus)

Molecular monitoring of the developmental bacterial community in the gastrointestinal tract of Japanese infants

Songjinda, P., Nakayama, J., Kuroki, Y., Tanaka, S., Fukuda, S., Kiyohara, C., Yamamoto, T., Izuchi, K., Shirakawa, T. & Sonomoto, K., Mar 1 2005, In : Bioscience, Biotechnology and Biochemistry. 69, 3, p. 638-641 4 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

NAD(P)H oxidases in rat basilar arterial endothelial cells

Ago, T., Kitazono, T., Kuroda, J., Kumai, Y., Kamouchi, M., Ooboshi, H., Wakisaka, M., Kawahara, T., Rokutan, K., Ibayashi, S. & Iida, M., May 1 2005, In : Stroke. 36, 5, p. 1040-1046 7 p.

Research output: Contribution to journalArticle

99 Citations (Scopus)

NQO1, MPO, and the risk of lung cancer: A HuGE review

Kiyohara, C., Yoshimasu, K., Takayama, K. & Nakanishi, Y., Sep 1 2005, In : Genetics in Medicine. 7, 7, p. 463-478 16 p.

Research output: Contribution to journalReview article

86 Citations (Scopus)

Postischemic gene transfer of interleukin-10 protects against both focal and global brain ischemia

Ooboshi, H., Ibayashi, S., Shichita, T., Kumai, Y., Takada, J., Ago, T., Arakawa, S., Sugimori, H., Kamouchi, M., Kitazono, T. & Iida, M., Feb 22 2005, In : Circulation. 111, 7, p. 913-919 7 p.

Research output: Contribution to journalArticle

142 Citations (Scopus)

Postischemic gene transfer of midkine, a neurotrophic factor, protects against focal brain ischemia

Takada, J., Ooboshi, H., Ago, T., Kitazono, T., Yao, H., Kadomatsu, K., Muramatsu, T., Ibayashi, S. & Iida, M., Mar 1 2005, In : Gene Therapy. 12, 6, p. 487-493 7 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

Poststenotic flow and intracranial hemodynamics in patients with carotid stenosis: Transoral carotid ultrasonography study

Kamouchi, M., Kishikawa, K., Okada, Y., Inoue, T., Ibayashi, S. & Iida, M., Dec 1 2005, In : American Journal of Neuroradiology. 26, 1, p. 76-81 6 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Prediction of coronary artery disease in patients undergoing carotid endarterectomy

Shimada, T., Toyoda, K., Inoue, T., Kamouchi, M., Matsumoto, T., Hiyamuta, K., Imaizumi, T. & Okada, Y., Oct 2005, In : Journal of Neurosurgery. 103, 4, p. 593-596 4 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Prolongation of the QT interval in primary aldosteronism

Matsumura, K., Fujii, K., Kansui, Y., Arima, H. & Iida, M., Jan 1 2005, In : Clinical and Experimental Pharmacology and Physiology. 32, 1-2, p. 66-69 4 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Reappraisal of flow velocity ratio in common carotid artery to predict hemodynamic change in carotid stenosis

Kamouchi, M., Kishikawa, K., Okada, Y., Inoue, T., Ibayashi, S. & Iida, M., Dec 1 2005, In : American Journal of Neuroradiology. 26, 4, p. 957-962 6 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Relationship between C-reactive protein and glucose levels in community-dwelling subjects without diabetes: The Hisayama study

Doi, Y., Kiyohara, Y., Kubo, M., Tanizaki, Y., Okubo, K., Ninomiya, T., Iwase, M. & Iida, M., May 1 2005, In : Diabetes care. 28, 5, p. 1211-1213 3 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Role of serine 10 phosphorylation in p27 stabilization revealed by analysis of p27 knock-in mice harboring a serine 10 mutation

Kotake, Y., Nakayama, K., Ishida, N. & Nakayama, K., Jan 14 2005, In : Journal of Biological Chemistry. 280, 2, p. 1095-1102 8 p.

Research output: Contribution to journalArticle

62 Citations (Scopus)

SCH00013, a novel Ca2+ sensitizer with positive inotropic and no chronotropic action in heart failure

Tadano, N., Morimoto, S., Yoshimura, A., Miura, M., Yoshioka, K., Sakato, M., Ohtsuki, I., Miwa, Y., Takahashi-Yanaga, F. & Sasaguri, T., Jan 1 2005, In : Journal of Pharmacological Sciences. 97, 1, p. 53-60 8 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Secular trends in the incidence, mortality, and survival rate of gastric cancer in a general Japanese population: The Hisayama study

Tanaka, K., Kiyohara, Y., Kubo, M., Matsumoto, T., Tanizaki, Y., Okubo, K., Ninomiya, T., Oishi, Y., Shikata, K. & Iida, M., Jun 1 2005, In : Cancer Causes and Control. 16, 5, p. 573-578 6 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Selective induction of ΔFosB in the brain after transient forebrain ischemia accompanied by an increased expression of galectin-1, and the implication of ΔFosB and galectin-1 in neuroprotection and neurogenesis

Kurushima, H., Ohno, M., Miura, T., Nakamura, T. Y., Horie, H., Kadoya, T., Ooboshi, H., Kitazono, T., Ibayashi, S., Iida, M. & Nakabeppu, Y., Aug 1 2005, In : Cell Death and Differentiation. 12, 8, p. 1078-1096 19 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Ten year recurrence after first ever stroke in a Japanese community: The Hisayama study

Hata, J., Tanizaki, Y., Kiyohara, Y., Kato, I., Kubo, M., Tanaka, K., Okubo, K., Nakamura, H., Oishi, Y., Ibayashi, S. & Iida, M., Mar 1 2005, In : Journal of Neurology, Neurosurgery and Psychiatry. 76, 3, p. 368-372 5 p.

Research output: Contribution to journalArticle

67 Citations (Scopus)

The NADPH oxidase Nox3 constitutively produces superoxide in a p22 phox-dependent manner: Its regulation by oxidase organizers and activators

Ueno, N., Takeya, R., Miyano, K., Kikuchi, H. & Sumimoto, H., Jun 17 2005, In : Journal of Biological Chemistry. 280, 24, p. 23328-23339 12 p.

Research output: Contribution to journalArticle

136 Citations (Scopus)

The yeast eIF4E-associated protein Eap1p attenuates GCN4 translation upon TOR-inactivation

Matsuo, R., Kubota, H., Obata, T., Kito, K., Ota, K., Kitazono, T., Ibayashi, S., Sasaki, T., Iida, M. & Ito, T., Apr 25 2005, In : FEBS Letters. 579, 11, p. 2433-2438 6 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)
2004

Activation of the flavoprotein domain of gp91phox upon interaction with N-terminal p67phox (1-210) and the Rac complex

Nisimoto, Y., Ogawa, H., Miyano, K. & Tamura, M., Jul 27 2004, In : Biochemistry. 43, 29, p. 9567-9575 9 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Anti-monocyte chemoattractant protein-1 gene therapy protects against focal brain ischemia in hypertensive rats

Kumai, Y., Ooboshi, H., Takada, J., Kamouchi, M., Kitazono, T., Egashira, K., Ibayashi, S. & Iida, M., Dec 2004, In : Journal of Cerebral Blood Flow and Metabolism. 24, 12, p. 1359-1368 10 p.

Research output: Contribution to journalArticle

51 Citations (Scopus)

Association of metabolic gene polymorphisms with tobacco consumption in healthy controls

Smits, K. M., Benhamou, S., Garte, S., Weijenberg, M. P., Alamanos, Y., Ambrosone, C., Autrup, H., Autrup, J. L., Baranova, H., Bathum, L., Boffetta, P., Bouchardy, C., Brockmoller, J., Butkiewicz, D., Cascorbi, I., Clapper, M. L., Coutelle, C., Daly, A. K., Muzi, G., Dolzan, V. & 50 others, Duzhak, T. G., Farker, K., Golka, K., Haugen, A., Hein, D. W., Hildesheim, A., Hirvonen, A., Hsieh, L. L., Ingelman-Sundberg, M., Kalina, I., Kang, D., Katoh, T., Kihara, M., Ono-Kihara, M., Kim, H., Kiyohara, C., Kremers, P., Lazarus, P., Le Marchand, L., Lechner, M. C., London, S., Manni, J. J., Maugard, C. M., Morgan, G. J., Morita, S., Nazar-Stewart, V., Kristensen, V. N., Oda, Y., Parl, F. F., Peters, W. H. M., Rannug, A., Rebbeck, T., Pinto, L. F. R., Risch, A., Romkes, M., Šalagovic, J., Schoket, B., Seidegard, J., Shields, P. G., Sim, E., Sinnett, D., Strange, R. C., Stucker, I., Sugimura, H., To-Figueras, J., Vineis, P., Yu, M. C., Zheng, W., Pedotti, P. & Taioli, E., Jun 10 2004, In : International Journal of Cancer. 110, 2, p. 266-270 5 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Association of QT interval with blood pressure in 80-year-old subjects

Matsumura, K., Takata, Y., Ansai, T., Awano, S., Takehara, T., Fujii, K. & Iida, M., Jun 1 2004, In : Hypertension Research. 27, 6, p. 387-391 5 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Brain infarction associated with antiphospholipid antibody syndrome caused by paradoxical embolism through patent foramen ovale [4]

Ago, T., Ooboshi, H., Kitazono, T., Imamura, T., Takada, J., Ibayashi, S. & Iida, M., Jun 1 2004, In : Journal of Neurology. 251, 6, p. 757-759 3 p.

Research output: Contribution to journalLetter

7 Citations (Scopus)

Calcium influx pathways in rat CNS pericytes

Kamouchi, M., Kitazono, T., Ago, T., Wakisaka, M., Ooboshi, H., Ibayashi, S. & Iida, M., Jul 26 2004, In : Molecular Brain Research. 126, 2, p. 114-120 7 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Crossed cerebellar hypoperfusion in hyperacute ischemic stroke

Kamouchi, M., Fujishima, M., Saku, Y., Ibayashi, S. & Iida, M., Oct 15 2004, In : Journal of the Neurological Sciences. 225, 1-2, p. 65-69 5 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27Kip1 at G1 phase

Kamura, T., Hara, T., Matsumoto, M., Ishida, N., Okumura, F., Hatakeyama, S., Yoshida, M., Nakayama, K. & Nakayama, K., Dec 1 2004, In : Nature Cell Biology. 6, 12, p. 1229-1235 7 p.

Research output: Contribution to journalArticle

320 Citations (Scopus)
16 Citations (Scopus)

Effects of U-37883A on intracellular Ca 2+-activated large-conductance K + channels in pig proximal urethral myocytes

Teramoto, N., Aishima, M., Zhu, H. L., Tomoda, T., Yunoki, T., Takahashi-Yanaga, F., Brading, A. F. & Ito, Y., Dec 3 2004, In : European Journal of Pharmacology. 506, 1, p. 1-7 7 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Free radical scavenger, edaravone, in stroke with internal carotid artery occlusion

Toyoda, K., Fujii, K., Kamouchi, M., Nakane, H., Arihiro, S., Okada, Y., Ibayashi, S. & Iida, M., Jun 15 2004, In : Journal of the Neurological Sciences. 221, 1-2, p. 11-17 7 p.

Research output: Contribution to journalArticle

116 Citations (Scopus)

Genetic Polymorphisms and Environmental Risk of Lung Cancer: A Review

Kiyohara, C., Yoshimasu, K., Shirakawa, T. & Hopkin, J. M., Jan 1 2004, In : Reviews on Environmental Health. 19, 1, p. 15-38 24 p.

Research output: Contribution to journalReview article

41 Citations (Scopus)

Ghrelin Acts at the Nucleus of the Solitary Tract to Decrease Arterial Pressure in Rats

Lin, Y., Matsumura, K., Fukuhara, M., Kagiyama, S., Fujii, K. & Iida, M., May 1 2004, In : Hypertension. 43, 5, p. 977-982 6 p.

Research output: Contribution to journalArticle

157 Citations (Scopus)

Glycogen synthase kinase-3β is tyrosine-phosphorylated by MEK1 in human skin fibroblasts

Takahashi-Yanaga, F., Shiraishi, F., Hirata, M., Miwa, Y., Morimoto, S. & Sasaguri, T., Apr 2 2004, In : Biochemical and Biophysical Research Communications. 316, 2, p. 411-415 5 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

Hyperhomocysteinemia and the development of chronic kidney disease in a general population: The Hisayama study

Ninomiya, T., Kiyohara, Y., Kubo, M., Tanizaki, Y., Tanaka, K., Okubo, K., Nakamura, H., Hata, J., Oishi, Y., Kato, I., Hirakata, H. & Iida, M., Sep 1 2004, In : American Journal of Kidney Diseases. 44, 3, p. 437-445 9 p.

Research output: Contribution to journalArticle

62 Citations (Scopus)

Improvement of blood pressure control in a hypertension clinic: A 10-year follow-up study

Ohta, Y., Tsuchihashi, T., Fujii, K., Matsumura, K., Ohya, Y., Uezono, K., Abe, I. & Iida, M., Apr 1 2004, In : Journal of human hypertension. 18, 4, p. 273-278 6 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Inactivation of neutrophil NADPH oxidase upon dilution and its prevention by cross-link and fusion of phox proteins

Miyano, K., Kitahara, H., Ohmi, S., Kakinuma, K. & Tamura, M., Nov 1 2004, In : Archives of Biochemistry and Biophysics. 431, 1, p. 129-137 9 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Involvement of clusterin in 15-deoxy-Δ12,14-prostaglandin J2-induced vascular smooth muscle cell differentiation

Miwa, Y., Takahashi-Yanaga, F., Morimoto, S. & Sasaguri, T., Jun 18 2004, In : Biochemical and Biophysical Research Communications. 319, 1, p. 163-168 6 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Methylenetetrahydrofolate reductase polymorphism, alcohol intake, and risks of colon and rectal cancers in Korea

Kim, D. H., Ahn, Y. O., Lee, B. H., Tsuji, E., Kiyohara, C. & Kono, S., Dec 28 2004, In : Cancer Letters. 216, 2, p. 199-205 7 p.

Research output: Contribution to journalArticle

48 Citations (Scopus)

Modulation of sympathetic activity by ghrelin in the central nervous system

Matsumura, K., Sep 2004, In : Nippon rinsho. Japanese journal of clinical medicine. 62 Suppl 9, p. 373-376 4 p.

Research output: Contribution to journalReview article

Mouse Fbw7/Sel-10/Cdc4 Is Required for Notch Degradation during Vascular Development

Tsunematsu, R., Nakayama, K., Oike, Y., Nishiyama, M., Ishida, N., Hatakeyama, S., Bessho, Y., Kageyama, R., Suda, T. & Nakayama, K., Mar 5 2004, In : Journal of Biological Chemistry. 279, 10, p. 9417-9423 7 p.

Research output: Contribution to journalArticle

193 Citations (Scopus)

Novel Regulatory Mechanisms of CD40-Induced Prostanoid Synthesis by IL-4 and IL-10 in Human Monocytes

Inoue, Y., Otsuka, T., Niiro, H., Nagano, S., Arinobu, Y., Ogami, E., Akahoshi, M., Miyake, K., Ninomiya, I., Shimizu, S., Nakashima, H. & Harada, M., Feb 15 2004, In : Journal of Immunology. 172, 4, p. 2147-2154 8 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Nox4 as the Major Catalytic Component of an Endothelial NAD(P)H Oxidase

Ago, T., Kitazono, T., Ooboshi, H., Iyama, T., Han, Y. H., Takada, J., Wakisaka, M., Ibayashi, S., Utsumi, H. & Iida, M., Jan 20 2004, In : Circulation. 109, 2, p. 227-233 7 p.

Research output: Contribution to journalArticle

405 Citations (Scopus)

Pharmacokinetics Study of Low Dose of Metformin Clinically Used in Japan

Iwase, M., Nohara, S., Sasaki, N., Himeno, T., Nishida, M., Yoshinari, M., Yoshizumi, H., Mukai, N., Doi, Y., Morizono, S., Asano, T., Tsutsu, N. & Iida, M., May 19 2004, In : Journal of the Japan Diabetes Society. 47, 3, p. 197-201 5 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)