Department of Medical Education

Research Output 1983 2020

2003
118 Citations (Scopus)

CYP1A1 T3801 C polymorphism and lung cancer: A pooled analysis of 2,451 cases and 3,358 controls

Vineis, P., Veglia, F., Benhamou, S., Butkiewicz, D., Cascorbi, I., Clapper, M. L., Dolzan, V., Haugen, A., Hirvonen, A., Ingelman-Sundberg, M., Kihara, M., Kiyohara, C., Kremers, P., Le Marchand, L., Ohshima, S., Pastorelli, R., Rannug, A., Romkes, M., Schoket, B., Shields, P. & 6 others, Strange, R. C., Stucker, I., Sugimura, H., Garte, S., Gaspari, L. & Taioli, E., May 1 2003, In : International Journal of Cancer. 104, 5, p. 650-657 8 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP1A1
Lung Neoplasms
Restriction Fragment Length Polymorphisms
Squamous Cell Carcinoma
Adenocarcinoma
219 Citations (Scopus)

Degradation of p57Kip2 mediated by SCFSkp2-dependent ubiquitylation

Kamura, T., Hara, T., Kotoshiba, S., Yada, M., Ishida, N., Imaki, H., Hatakeyama, S., Nakayama, K. & Nakayama, K. I., Sep 2 2003, In : Proceedings of the National Academy of Sciences of the United States of America. 100, 18, p. 10231-10236 6 p.

Research output: Contribution to journalArticle

Ubiquitination
Cyclin-Dependent Kinase Inhibitor p57
Cell Cycle
Cyclin E
Ubiquitin-Protein Ligases
11 Citations (Scopus)

Depression among Caregivers of Patients with Chronic Obstructive Pulmonary Disease

Washio, M., Inoue, H., Kiyohara, C., Matsumoto, K., Koto, H., Nakanishi, Y., Arai, Y. & Mori, M., Dec 1 2003, In : International Medical Journal. 10, 4, p. 255-259 5 p.

Research output: Contribution to journalArticle

Chronic Obstructive Pulmonary Disease
Caregivers
Depression
Long-Term Care Insurance
Insurance
44 Citations (Scopus)

Deterioration of pre-existing hemiparesis brought about by subsequent ipsilateral lacunar infarction

Ago, T., Kitazono, T., Ooboshi, H., Takada, J., Yoshiura, T., Mihara, F., Ibayashi, S. & Iida, M., Aug 1 2003, In : Journal of Neurology Neurosurgery and Psychiatry. 74, 8, p. 1152-1153 2 p.

Research output: Contribution to journalArticle

Lacunar Stroke
Paresis
Motor Cortex
Putaminal Hemorrhage
Pyramidal Tracts
78 Citations (Scopus)

Dictyostelium differentiation-inducing factor-3 activates glycogen synthase kinase-3β and degrades cyclin D1 in mammalian cells

Takahashi-Yanaga, F., Taba, Y., Miwa, Y., Kubohara, Y., Watanabe, Y., Hirata, M., Morimoto, S. & Sasaguri, T., Mar 14 2003, In : Journal of Biological Chemistry. 278, 11, p. 9663-9670 8 p.

Research output: Contribution to journalArticle

Glycogen Synthase Kinase 3
Cyclin D1
Cells
Proteolysis
1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone
170 Citations (Scopus)

Direct involvement of the receptor-mediated apoptotic pathways in cisplatin-induced renal tubular cell death

Tsuruya, K., Ninomiya, T., Tokumoto, M., Hirakawa, M., Masutani, K., Taniguchi, M., Fukuda, K., Kanai, H., Kishihara, K., Hirakata, H. & Iida, M., Jan 1 2003, In : Kidney International. 63, 1, p. 72-82 11 p.

Research output: Contribution to journalArticle

Cisplatin
Cell Death
Kidney
Tumor Necrosis Factor Receptors
CD95 Antigens
47 Citations (Scopus)

Effects of carotid endarterectomy on cerebral blood flow and neuropsychological test performance in patients with high-grade carotid stenosis

Kishikawa, K., Kamouchi, M., Okada, Y., Inoue, T., Ibayashi, S. & Iida, M., Sep 15 2003, In : Journal of the Neurological Sciences. 213, 1-2, p. 19-24 6 p.

Research output: Contribution to journalArticle

Cerebrovascular Circulation
Carotid Endarterectomy
Neuropsychological Tests
Carotid Stenosis
Hematologic Tests
84 Citations (Scopus)

Estrogens Down-regulate p27Kip1 in Breast Cancer Cells through Skp2 and through Nuclear Export Mediated by the ERK Pathway

Foster, J. S., Fernando, R. I., Ishida, N., Nakayama, K. I. & Wimalasena, J., Oct 17 2003, In : Journal of Biological Chemistry. 278, 42, p. 41355-41366 12 p.

Research output: Contribution to journalArticle

Cell Nucleus Active Transport
Extracellular Signal-Regulated MAP Kinases
MCF-7 Cells
Estrogens
Estrogen Receptor Modulators
27 Citations (Scopus)

Genetic influences on smoking behavior and nicotine dependence: A review

Yoshimasu, K. & Kiyohara, C., Jan 1 2003, In : Journal of epidemiology. 13, 4, p. 183-192 10 p.

Research output: Contribution to journalReview article

Tobacco Use Disorder
Smoking
Mental Disorders
Genes
Schizophrenia
109 Citations (Scopus)

Interstitial pneumonia developed in a worker dealing with particles containing indium-tin oxide

Homma, T., Ueno, T., Sekizawa, K., Tanaka, A. & Hirata, M., May 1 2003, In : Journal of Occupational Health. 45, 3, p. 137-139 3 p.

Research output: Contribution to journalArticle

Tin Compounds
Indium
Metallurgy
indium tin oxide
76 Citations (Scopus)

Neural regulation of blood pressure by leptin and the related peptides

Matsumura, K., Tsuchihashi, T., Fujii, K. & Iida, M., Jul 15 2003, In : Regulatory Peptides. 114, 2-3, p. 79-86 8 p.

Research output: Contribution to journalReview article

Blood pressure
Leptin
Blood Pressure
Melanocyte-Stimulating Hormones
Peptides
2 Citations (Scopus)

Novel Nonsynonymous Polymorphisms of the CYP1AI Gene in Japanese

Saito, T., Egashira, M., Kiyotani, K., Fujieda, M., Yamazaki, H., Kiyohara, C., Kunitoh, H. & Kamataki, T., Feb 1 2003, In : Drug metabolism and pharmacokinetics. 18, 3, p. 218-221 4 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP1A1
Single Nucleotide Polymorphism
Names
Genes
Nonsense Codon
41 Citations (Scopus)

Photothrombotic Middle Cerebral Artery Occlusion and Reperfusion Laser System in Spontaneously Hypertensive Rats

Yao, H., Sugimori, H., Fukuda, K., Takada, J., Ooboshi, H., Kitazono, T., Ibayashi, S. & Iida, M., Nov 1 2003, In : Stroke. 34, 11, p. 2716-2721 6 p.

Research output: Contribution to journalArticle

Middle Cerebral Artery Infarction
Inbred SHR Rats
Reperfusion
Cerebrovascular Circulation
Solid-State Lasers
13 Citations (Scopus)

Pulmonary Squamous Cyst Induced by Exposure to Indium Arsenide in Hamsters

Tanaka, A., Hirata, M. & Omura, M., Nov 1 2003, In : Journal of Occupational Health. 45, 6, p. 405-407 3 p.

Research output: Contribution to journalArticle

Arsenicals
Indium
Carcinogens
Animals
Semiconductor materials
41 Citations (Scopus)

Relation of plasma folate and methylenetetrahydrofolate reductase C677T polymorphism to colorectal adenomas

Marugame, T., Tsuji, E., Kiyohara, C., Eguchi, H., Oda, T., Shinchi, K. & Kono, S., Feb 1 2003, In : International Journal of Epidemiology. 32, 1, p. 64-66 3 p.

Research output: Contribution to journalArticle

Methylenetetrahydrofolate Reductase (NADPH2)
Folic Acid
Adenoma
Genotype
Odds Ratio

Research methodology

Dunn, W. R., Lyman, S. & Marx, R., Oct 2003, In : Arthroscopy - Journal of Arthroscopic and Related Surgery. 19, 8, p. 870-873 4 p.

Research output: Contribution to journalReview article

Sports Medicine
Orthopedics
Research Design
Research
60 Citations (Scopus)

Risk modification by CYP1A1 and GSTM1 polymorphisms in the association of environmental tobacco smoke and lung cancer: A case-control study in Japanese nonsmoking women

Kiyohara, C., Wakai, K., Mikami, H., Sido, K., Ando, M. & Ohno, Y., Oct 20 2003, In : International Journal of Cancer. 107, 1, p. 139-144 6 p.

Research output: Contribution to journalArticle

Cytochromes
Smoke
Tobacco
Case-Control Studies
Lung Neoplasms
7 Citations (Scopus)

Systemic effects of orally administered p, p′-DDE on immature male Wistar rats during pubertal period

Makita, Y., Matsuura, T., Ogata, R., Romero, Y., Omura, M., Tanaka, A., Hirata, M. & Inoue, N., Jul 1 2003, In : Journal of Occupational Health. 45, 4, p. 223-227 5 p.

Research output: Contribution to journalArticle

Dichlorodiphenyl Dichloroethylene
Wistar Rats
Sexual Maturation
Sperm Count
Biochemistry

Systemic toxicity of p,p'-DDE in aged male Wistar rats following oral administration.

Makita, Y., Matsuura, T., Ogata, R., Omura, M., Tanaka, A., Hirata, M. & Inoue, N., Apr 2003, In : Fukuoka igaku zasshi = Hukuoka acta medica. 94, 4, p. 59-65 7 p.

Research output: Contribution to journalArticle

Dichlorodiphenyl Dichloroethylene
Oral Administration
Wistar Rats
Organ Size
Serum
10 Citations (Scopus)
Habits
Japan
Smoking
Students
Tobacco Products
15 Citations (Scopus)

Ultrasonographically predicting the extent of collateral flow through superficial temporal artery-to-middle cerebral artery anastomosis

Arakawa, S., Kamouchi, M., Okada, Y., Kishikawa, K., Omae, T., Inoue, T., Ibayashi, S. & Fujishima, M., May 1 2003, In : American Journal of Neuroradiology. 24, 5, p. 886-891 6 p.

Research output: Contribution to journalArticle

Temporal Arteries
Middle Cerebral Artery
Blood Flow Velocity
Therapeutic Occlusion
Ultrasonography
2 Citations (Scopus)

Ultrasonographic detection of extracranial vertebral artery compression in bow hunter's brain ischemia caused by neck rotation

Kamouchi, M., Kishikawa, K., Matsuo, R., Yasumori, K., Inoue, T., Okada, Y. & Ibayashi, S., Aug 11 2003, In : Cerebrovascular Diseases. 16, 3, p. 303-305 3 p.

Research output: Contribution to journalArticle

Vertebrobasilar Insufficiency
Doppler Transcranial Ultrasonography
Doppler Color Ultrasonography
Cerebral Angiography
Vertebral Artery
2002
1 Citation (Scopus)

Acceptance of van Swieten's liquor in Japan

Takahashi, F., Jan 1 2002, In : Nihon ishigaku zasshi. [Journal of Japanese history of medicine]. 48, 4, p. 575-595 21 p.

Research output: Contribution to journalArticle

Japan
Mercuric Chloride
Mercury
Salivation
Therapeutics

Caspase-3-mediated α-smooth muscle actin cleavage during staurosporine-induced myofibroblast apoptosis

Nakazono, A., Takahashi-Yanaga, F., Furue, M. & Sasaguri, T., Dec 17 2002, In : Folia Pharmacologica Japonica. 120, SUPPL. 1, p. 94P-95P

Research output: Contribution to journalArticle

Staurosporine
Myofibroblasts
Caspase 3
Smooth Muscle
Actins
176 Citations (Scopus)

Central ghrelin modulates sympathetic activity in conscious rabbits

Matsumura, K., Tsuchihashi, T., Fujii, K., Abe, I. & Iida, M., Nov 1 2002, In : Hypertension. 40, 5, p. 694-699 6 p.

Research output: Contribution to journalArticle

Ghrelin
Rabbits
Arterial Pressure
Kidney
Heart Rate
43 Citations (Scopus)

Central α-melanocyte-stimulating hormone acts at melanocortin-4 receptor to activate sympathetic nervous system in conscious rabbits

Matsumura, K., Tsuchihashi, T., Abe, I. & Iida, M., Sep 6 2002, In : Brain Research. 948, 1-2, p. 145-148 4 p.

Research output: Contribution to journalArticle

Receptor, Melanocortin, Type 4
Melanocyte-Stimulating Hormones
Sympathetic Nervous System
Rabbits
Injections
7 Citations (Scopus)

Cerebral infarction due to carotid occlusion caused by cervical vagal neurilemmoma

Matsuo, R., Kamouchi, M., Inoue, T., Okada, Y. & Ibayashi, S., May 27 2002, In : Stroke. 33, 5, p. 1428-1431 4 p.

Research output: Contribution to journalArticle

Neurilemmoma
Cerebral Infarction
Internal Carotid Artery
Neck
Neoplasms
13 Citations (Scopus)

Chronic administration of a tyrosine kinase inhibitor restores functional and morphological changes of the basilar artery during chronic hypertension

Kitayama, J., Kitazono, T., Ooboshi, H., Ago, T., Ohgami, T., Fujishima, M. & Ibayashi, S., Nov 1 2002, In : Journal of hypertension. 20, 11, p. 2205-2211 7 p.

Research output: Contribution to journalArticle

Basilar Artery
Genistein
Protein-Tyrosine Kinases
Inbred WKY Rats
Hypertension
28 Citations (Scopus)

Chronic central infusion of orexin - A increases arterial pressure in rats

Lin, Y., Matsumura, K., Tsuchihashi, T., Abe, I. & Iida, M., Mar 15 2002, In : Brain Research Bulletin. 57, 5, p. 619-622 4 p.

Research output: Contribution to journalArticle

Arterial Pressure
Intraventricular Infusions
Blood Pressure
Drinking
Pentolinium Tartrate
8 Citations (Scopus)
Patient Readmission
Schizophrenia
Outpatients
Odds Ratio
Confidence Intervals

Ethical issues in cancer epidemiology and disease susceptibility genes

Washio, M., Kiyohara, C., Sugimori, H., Yamagata, Z. & Mori, M., Dec 1 2002, In : Tumor Research. 37, p. 41-48 8 p.

Research output: Contribution to journalReview article

Disease Susceptibility
Ethics
Epidemiology
Genes
Neoplasms
2 Citations (Scopus)

Gender difference in lung cancer susceptibility

Kiyohara, C., Yoshimasu, K. & Washio, M., Dec 1 2002, In : Tumor Research. 37, p. 1-7 7 p.

Research output: Contribution to journalReview article

Lung Neoplasms
Smoke
Tobacco Products
Cytochromes a1
Epidemiologic Studies
32 Citations (Scopus)

Genetic polymorphism of enzymes involved in xenobiotic metabolism and the risk of lung cancer

Kiyohara, C., Shirakawa, T. & Hopkin, J. M., Jun 18 2002, In : Environmental health and preventive medicine. 7, 2, p. 47-59 13 p.

Research output: Contribution to journalReview article

Xenobiotics
Genetic Polymorphisms
Lung Neoplasms
Enzymes
Cytochrome P-450 CYP2E1
127 Citations (Scopus)

Genetic polymorphisms and lung cancer susceptibility: A review

Kiyohara, C., Otsu, A., Shirakawa, T., Fukuda, S. & Hopkin, J. M., Sep 1 2002, In : Lung Cancer. 37, 3, p. 241-256 16 p.

Research output: Contribution to journalReview article

Genetic Polymorphisms
Lung Neoplasms
Genetic Predisposition to Disease
Carcinogens
Biomarkers
22 Citations (Scopus)

Increased activity of calcium channels and Rho-associated kinase in the basilar artery during chronic hypertension in vivo

Kitazono, T., Ago, T., Kamouchi, M., Santa, N., Ooboshi, H., Fujishima, M. & Ibayashi, S., May 1 2002, In : Journal of hypertension. 20, 5, p. 879-884 6 p.

Research output: Contribution to journalArticle

rho-Associated Kinases
Basilar Artery
Calcium Channels
Inbred WKY Rats
Inbred SHR Rats
16 Citations (Scopus)

Long-term effects of benidipine on cerebral vasoreactivity in hypertensive rats

Kitayama, J., Kitazono, T., Ooboshi, H., Takada, J., Fujishima, M. & Ibayashi, S., Mar 8 2002, In : European Journal of Pharmacology. 438, 3, p. 153-158 6 p.

Research output: Contribution to journalArticle

Inbred SHR Rats
Basilar Artery
Inbred WKY Rats
Nitroprusside
Acetylcholine
44 Citations (Scopus)

Molecular mechanisms of lipopolysaccharide-induced cyclooxygenase-2 expression in human neutrophils: Involvement of the mitogen-activated protein kinase pathway and regulation by anti-inflammatory cytokines

Nagano, S., Otsuka, T., Niiro, H., Yamaoka, K., Arinobu, Y., Ogami, E., Akahoshi, M., Inoue, Y., Miyake, K., Nakashima, H., Niho, Y. & Harada, M., Aug 7 2002, In : International Immunology. 14, 7, p. 733-740 8 p.

Research output: Contribution to journalArticle

Cyclooxygenase 2
Mitogen-Activated Protein Kinases
Lipopolysaccharides
Neutrophils
Anti-Inflammatory Agents
7 Citations (Scopus)

Myeloperoxidase-antineutrophil cytoplasmic antibody-associated glomerulonephritis superimposed on biopsy-proven diabetic nephrosclerosis.

Ninomiya, T., Kanai, H., Hirakawa, M., Arimura, Y., Masutani, K., Kashiwagi, M., Nakamura, S., Koga, Y., Fukuda, K. & Hirakata, H., Jan 2002, In : American journal of kidney diseases : the official journal of the National Kidney Foundation. 39, 1, p. E4

Research output: Contribution to journalArticle

Nephrosclerosis
Antineutrophil Cytoplasmic Antibodies
Glomerulonephritis
Peroxidase
Kidney
229 Citations (Scopus)

Phosphorylation of p27Kip1 on serine 10 is required for its binding to CRM1 and nuclear export

Ishida, N., Hara, T., Kamura, T., Yoshida, M., Nakayama, K. & Nakayama, K., Apr 26 2002, In : Journal of Biological Chemistry. 277, 17, p. 14355-14358 4 p.

Research output: Contribution to journalArticle

Phosphorylation
Cell Nucleus Active Transport
Serine
SKP Cullin F-Box Protein Ligases
Substitution reactions
39 Citations (Scopus)

Pulmonary toxicity of indium-tin oxide and indium phosphide after intratracheal instillations into the Lung of hamsters

Tanaka, A., Hirata, M., Omura, M., Inoue, N., Ueno, T., Homma, T. & Sekizawa, K., May 13 2002, In : Journal of Occupational Health. 44, 2, p. 99-102 4 p.

Research output: Contribution to journalArticle

Indium
Cricetinae
Toxicity
Lung
indium phosphide
17 Citations (Scopus)

Role of CA2+-activated K+ channels in the regulation of basilar arterial tone in spontaneously hypertensive rats

Kamouchi, M., Kitazono, T., Nagao, T., Fujishima, M. & Ibayashi, S., Jun 26 2002, In : Clinical and Experimental Pharmacology and Physiology. 29, 7, p. 575-581 7 p.

Research output: Contribution to journalArticle

Basilar Artery
Inbred SHR Rats
Cerebral Arteries
Inbred WKY Rats
Cerebrovascular Circulation

Safe endoscopic resection using a detachable snare: Large pedunculated Brunner's gland hyperplasia

Kubokawa, M., Hata, J., Ochiai, T., Araki, Y., Ito, K. I., Matsumoto, M., Hamada, S., Harada, N., Nishi, H., Tani, K. & Nawata, H., Oct 10 2002, In : Digestive Endoscopy. 14, 3, p. 107-109 3 p.

Research output: Contribution to journalArticle

Brunner Glands
Hyperplasia
Polyps
Hemorrhage
Endoscopy
13 Citations (Scopus)

Staurosporine-induced cleavage of α-smooth muscle actin during myofibroblast apoptosis

Nakazono-Kusaba, A., Takahashi-Yanaga, F., Morimoto, S., Furue, M. & Sasaguri, T., Jan 1 2002, In : Journal of Investigative Dermatology. 119, 5, p. 1008-1013 6 p.

Research output: Contribution to journalArticle

Staurosporine
Myofibroblasts
Smooth Muscle
Muscle
Actins
18 Citations (Scopus)

Testicular toxicity evaluation of indium-tin oxide

Omura, M., Tanaka, A., Hirata, M., Inoue, N., Ueno, T., Homma, T. & Sekizawa, K., May 11 2002, In : Journal of Occupational Health. 44, 2, p. 105-107 3 p.

Research output: Contribution to journalArticle

Indium
Toxicity
indium tin oxide
4 Citations (Scopus)
Antimony Potassium Tartrate
Antimony
Body Weight
Testis
Genitalia
2001
22 Citations (Scopus)

Adenovirus-mediated gene transfer to ischemic brain ischemic flow threshold for transgene expression

Ooboshi, H., Ibayashi, S., Takada, J., Yao, H., Kitazono, T. & Fujishima, M., Jan 1 2001, In : Stroke. 32, 4, p. 1043-1047 5 p.

Research output: Contribution to journalArticle

Cerebrovascular Circulation
Transgenes
Adenoviridae
Ischemia
Brain Ischemia
36 Citations (Scopus)

A fusion protein between rac and p67phox (1 - 210) reconstitutes NADPH oxidase with higher activity and stability than the individual components

Miyano, K., Ogasawara, S., Han, C. H., Fukuda, H. & Tamura, M., Nov 20 2001, In : Biochemistry. 40, 46, p. 14089-14097 9 p.

Research output: Contribution to journalArticle

rac GTP-Binding Proteins
NADPH Oxidase
Fusion reactions
Chemical activation
Proteins
21 Citations (Scopus)

Apolipoprotein E genotype, serum lipids, and colorectal adenomas in Japanese men

Shinomiya, S., Sasaki, J., Kiyohara, C., Tsuji, E., Inoue, H., Marugame, T., Handa, K., Hayabuchi, H., Hamada, H., Eguchi, H., Fukushima, Y. & Kono, S., Mar 10 2001, In : Cancer Letters. 164, 1, p. 33-40 8 p.

Research output: Contribution to journalArticle

Apolipoproteins E
Adenoma
Genotype
Lipids
Serum
29 Citations (Scopus)

Association of body mass index with blood pressure in 80-year-old subjects

Matsumura, K., Ansai, T., Awano, S., Hamasaki, T., Akifusa, S., Takehara, T., Abe, I. & Takata, Y., Dec 24 2001, In : Journal of hypertension. 19, 12, p. 2165-2169 5 p.

Research output: Contribution to journalArticle

Body Mass Index
Blood Pressure
Obesity
Hypertension
Creatinine
21 Citations (Scopus)

Bradykinin mediates, the acute effect of an angiotensin-converting enzyme inhibitor on cerebral autoregulation in rats

Takada, J., Ibayashi, S., Nagao, T., Ooboshi, H., Kitazono, T. & Fujishima, M., Jan 1 2001, In : Stroke. 32, 5, p. 1216-1219 4 p.

Research output: Contribution to journalArticle

Cerebrovascular Circulation
Bradykinin
Angiotensin-Converting Enzyme Inhibitors
Homeostasis
Captopril