Department of Medical Education

Research Output 1983 2019

1996
58 Citations (Scopus)

Suppression of superoxide anion production by interleukin-10 is accompanied by a downregulation of the genes for subunit proteins of NADPH oxidase

Kuga, S., Otsuka, T., Niiro, H., Nunoi, H., Nemoto, Y., Nakano, T., Ogo, T., Umei, T. & Niho, Y., Mar 20 1996, In : Experimental Hematology. 24, 2, p. 151-157 7 p.

Research output: Contribution to journalArticle

NADPH Oxidase
Superoxides
Interleukin-10
Down-Regulation
Proteins
39 Citations (Scopus)

Testicular toxicity evaluation of arsenic-containing binary compound semiconductors, gallium arsenide and indium arsenide, in hamsters

Omura, M., Hirata, M., Tanaka, A., Zhao, M., Makita, Y., Inoue, N., Gotoh, K. & Ishinishi, N., Dec 16 1996, In : Toxicology Letters. 89, 2, p. 123-129 7 p.

Research output: Contribution to journalArticle

Semiconductors
Arsenic
Cricetinae
Toxicity
Semiconductor materials
49 Citations (Scopus)

Testicular toxicity of gallium arsenide, indium arsenide, and arsenic oxide in rats by repetitive intratracheal instillation

Omura, M., Tanaka, A., Hirata, M., Zhao, M., Makita, Y., Inoue, N., Gotoh, K. & Ishinishi, N., Jan 1 1996, In : Fundamental and Applied Toxicology. 32, 1, p. 72-78 7 p.

Research output: Contribution to journalArticle

Arsenic
Oxides
Toxicity
Rats
Sperm Count
116 Citations (Scopus)

The relationship between aryl hydrocarbon hydroxylase and polymorphisms of the CYP1A1 gene

Kiyohara, C., Hirohata, T. & Inutsuka, S., Jan 1 1996, In : Japanese Journal of Cancer Research. 87, 1, p. 18-24 7 p.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Hydroxylases
Cytochrome P-450 CYP1A1
Genotype
Genes
isoleucylvaline
48 Citations (Scopus)

Dilatation of the basilar artery in response to selective activation of endothelin B receptors in vivo

Kitazono, T., Heistad, D. D. & Faraci, F. M., Jan 1 1995, In : Journal of Pharmacology and Experimental Therapeutics. 273, 1, p. 1-6 6 p.

Research output: Contribution to journalArticle

Endothelin B Receptors
Basilar Artery
Dilatation
Vasodilator Agents
Endothelins
1 Citation (Scopus)

Effects of polychlorinated dibenzo-p-dioxin and dibenzofuran congeners in human lymphoblastoid cells on aryl hydrocarbon hydroxylase activity

Kiyohara, C., Hirohata, T. & Masuda, Y., Jan 1 1995, In : Chemosphere. 31, 7, p. 3673-3680 8 p.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Hydroxylases
dibenzofuran
dioxin
Hydrocarbons
hydrocarbon
2 Citations (Scopus)

General characteristic and toxicity of VX

Inoue, N. & Hirata, M., Nov 1 1995, In : Fukuoka igaku zasshi = Hukuoka acta medica. 86, 11, p. 405-410 6 p.

Research output: Contribution to journalReview article

Organothiophosphorus Compounds
Chemical Warfare Agents
VX
88 Citations (Scopus)

Inhibition by interleukin-10 of inducible cyclooxygenase expression in lipopolysaccharide-stimulated monocytes: Its underlying mechanism in comparison with interleukin-4

Niiro, H., Otsuka, T., Tanabe, T., Hara, S., Kuga, S., Nemoto, Y., Tanaka, Y., Nakashima, H., Kitajima, S., Abe, M. & Niho, Y., Jan 1 1995, In : Blood. 85, 12, p. 3736-3745 10 p.

Research output: Contribution to journalArticle

Cyclooxygenase 2
Prostaglandin-Endoperoxide Synthases
Interleukin-4
Interleukin-10
Lipopolysaccharides
3 Citations (Scopus)

Inhibitory Effects of Interleukin (IL)-10 and Viral IL-10 (vIL-10) on the Functions of Monocytes/Macrophages

Nemoto, Y., Otsuka, T., Niiro, H., Kuga, S., Tanaka, Y., Nakashima, H. & Niho, Y., Jan 1 1995, In : Japanese Journal of Clinical Immunology. 18, 2, p. 152-159 8 p.

Research output: Contribution to journalArticle

Interleukin-10
Monocytes
Macrophages
Interferons
Nitric Oxide
86 Citations (Scopus)

Opposing actions of angiotensin-(1-7) and angiotensin II in the brain of transgenic hypertensive rats

Moriguchi, A., Tallant, E. A., Matsumura, K., Reilly, T. M., Walton, H., Ganten, D. & Ferrario, C. M., Jan 1 1995, In : Hypertension. 25, 6, p. 1260-1265 6 p.

Research output: Contribution to journalArticle

Transgenic Rats
Angiotensin II
Antibodies
Brain
Lisinopril
20 Citations (Scopus)

Phenylarsine oxide inhibits tyrosine phosphorylation of phospholipase Cγ2 in human platelets and phospholipase Cγ1 in NIH-3T3 fibroblasts

Takahashi, F., Asselin, J., Schieven, G. L. & Watson, S. P., Jul 17 1995, In : FEBS Letters. 368, 2, p. 377-380 4 p.

Research output: Contribution to journalArticle

Phosphorylation
Phospholipases
Fibroblasts
Platelets
Tyrosine
86 Citations (Scopus)

Polymorphisms of human Ah receptor gene are not involved in lung cancer

Kawajiri, K., Watanabe, J., Eguchi, H., Nakachi, K., Kiyohara, C. & Hayashi, S. I., Jan 1 1995, In : Pharmacogenetics. 5, 3, p. 151-158 8 p.

Research output: Contribution to journalArticle

Lung Neoplasms
Gene Pool
Cytochrome P-450 CYP1A1
Germ Cells
Codon
9 Citations (Scopus)

Short Communication Toxic Effects of Gallium Arsenide on Sperm in Rats by Repeated Intratracheal Instillations

Omura, M., Tanaka, A., Zhao, M., Hirata, M., Maxita, Y., Inoue, N. & Gotoh, K., Jan 1 1995, In : Journal of Occupational Health. 37, 3, 1 p.

Research output: Contribution to journalArticle

Poisons
Semiconductor lasers
Spermatozoa
Rats
Communication
123 Citations (Scopus)

Syk interacts with tyrosine-phosphorylated proteins in human platelets activated by collagen and cross-linking of the Fcγ-IIA receptor

Takahashi, F., Poole, A., Asselin, J., Blake, R., Schieven, G. L., Clark, E. A., Law, C. L. & Watson, S. P., Jan 1 1995, In : Biochemical Journal. 311, 2, p. 471-478 8 p.

Research output: Contribution to journalArticle

Fc Receptors
Platelets
Tyrosine
Collagen
Blood Platelets
7 Citations (Scopus)

Urinary Incontinence in Elderly Patients in the Chronic Stage of Stroke

Kamouchi, M., Yamashita, Y., Ibavashi, S., Takaba, H., Omae, T., Sadoshima, S. & Fujishima, M., Jan 1 1995, In : Nippon Ronen Igakkai zasshi. Japanese journal of geriatrics. 32, 11, p. 741-746 6 p.

Research output: Contribution to journalArticle

Urinary Incontinence
Activities of Daily Living
Stroke
Dementia
Putaminal Hemorrhage
1994
33 Citations (Scopus)

Ceramide does not mediate the effect of tumour necrosis factor α on superoxide generation in human neutrophils

Takahashi, F. & Watson, S. P., Jan 1 1994, In : Biochemical Journal. 298, 3, p. 733-738 6 p.

Research output: Contribution to journalArticle

Ceramides
Superoxides
Neutrophils
Tumor Necrosis Factor-alpha
Sphingomyelin Phosphodiesterase
2 Citations (Scopus)

Cerebellar Vermis Bleeding in a Patient with Hemophilia A: A Case Report

Kitazono, T., Okada, Y., Sadoshima, S., Utsunomiya, H. & Fujishima, M., Jan 1 1994, In : Angiology. 45, 4, p. 321-324 4 p.

Research output: Contribution to journalArticle

Hemophilia A
Craniocerebral Trauma
Neurologic Gait Disorders
Hemorrhage
Factor VIII
3 Citations (Scopus)

Dose-dependent testicular toxicity of propylene oxide in rats induced by repeated intraperitoneal injections

Omura, M., Tanaka, A., Mori, K., Hirata, M., Zao, M. & Inoue, N., Jan 1 1994, In : Fukuoka Acta Medica. 85, 7, p. 204-210 7 p.

Research output: Contribution to journalArticle

Intraperitoneal Injections
Sperm Count
Leydig Cells
Epididymis
Testosterone

Editorial comment

Kitazono, T., Jan 1 1994, In : Stroke. 25, 7, 1 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
Aryl Hydrocarbon Hydroxylases
Benzo(a)pyrene
Polychlorinated Biphenyls
Metabolites
Ascorbic Acid
8 Citations (Scopus)

Expression of the c‐kit ligand and interleukin 6 genes in mouse bone marrow stromal cell lines

Otsuka, T., Ogo, T., Nakano, T., Niiro, H., Kuga, S., Satoh, H., Furukawa, Y., Niho, Y. & Zipori, D., Jan 1 1994, In : STEM CELLS. 12, 4, p. 409-415 7 p.

Research output: Contribution to journalArticle

Mesenchymal Stromal Cells
Interleukin-6
Ligands
Cell Line
Stromal Cells
72 Citations (Scopus)

IL-10 inhibits prostaglandin E2 production by lipopolysaccharide-stimulated monocytes

Niiro, H., Otsuka, T., Kuga, S., Nemoto, Y., Abe, M., Hara, N., Nakano, T., Ogo, T. & Niho, Y., Apr 1 1994, In : International Immunology. 6, 4, p. 661-664 4 p.

Research output: Contribution to journalArticle

Dinoprostone
Interleukin-10
Lipopolysaccharides
Monocytes
Interleukin-4
15 Citations (Scopus)

Modulation of circadian rhythm of blood pressure by cortisol in patients with hypopituitarism

Matsumura, K., Abe, I., Fukuhara, M., Fujii, K., Ohya, Y., Okamura, K. & Fujishima, M., Jan 1 1994, In : Clinical and Experimental Hypertension. 16, 1, p. 55-66 12 p.

Research output: Contribution to journalArticle

Hypopituitarism
Circadian Rhythm
Hydrocortisone
Blood Pressure
Prednisolone

Naloxone augments sympathetic outflow induced by centrally administered endothelin in conscious rabbits

Matsumura, K., Abe, I., Fukuhara, M., Tominaga, M., Tsuchihashi, T., Kobayashi, K. & Fujishima, M., 1994, In : AM.J.PHYSIOL.. 266, 4 part 2

Research output: Contribution to journalArticle

naloxone
endothelins
Endothelins
Naloxone
rabbits
21 Citations (Scopus)

Naloxone augments sympathetic outflow induced by centrally administered endothelin in conscious rabbits

Matsumura, K., Abe, I., Fukuhara, M., Tominaga, M., Tsuchihashi, T., Kobayashi, K. & Fujishima, M., Jan 1 1994, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 266, 4 35-4

Research output: Contribution to journalArticle

Endothelins
Naloxone
Endothelin-1
Baroreflex
Rabbits
16 Citations (Scopus)

Pulmonary toxicity of indium arsenide and arsenic selenide following repeated intratracheal instillations to the lungs of hamsters

Tanaka, A., Hisanaga, A., Hirata, M., Omura, M., Inoue, N. & Ishinishi, N., Jan 1 1994, In : Applied Organometallic Chemistry. 8, 3, p. 265-271 7 p.

Research output: Contribution to journalArticle

Arsenic
Toxicity
Tumors
indium arsenide
Buffers
46 Citations (Scopus)
Diphosphates
Portal Vein
Nucleotides
Adenosine Triphosphate
Rabbits
1993
2 Citations (Scopus)

A role of aryl hydrocarbon hydroxylase inducibility in susceptibility to lung carcinogenesis

Kiyohara, C. & Hirohata, T., Dec 1 1993, In : Japanese Journal of Hygiene. 48, 6, p. 1027-1036 10 p.

Research output: Contribution to journalReview article

Aryl Hydrocarbon Hydroxylases
Lung Neoplasms
Carcinogenesis
Lung
Cytochrome P-450 CYP1A1
11 Citations (Scopus)

A target K+ channel for the LP-805-induced hyperpolarization in smooth muscle cells of the rabbit portal vein

Kamouchi, M., Kajioka, S., Sakai, T., Kitamura, K. & Kuriyama, H., Jan 1 1993, In : Naunyn-Schmiedeberg's Archives of Pharmacology. 347, 3, p. 329-335 7 p.

Research output: Contribution to journalArticle

Portal Vein
Smooth Muscle Myocytes
Rabbits
Large-Conductance Calcium-Activated Potassium Channels
Charybdotoxin
7 Citations (Scopus)

Attenuation of nocturnal BP fall in essential hypertensives with cerebral infarction.

Matsumura, K., Abe, I., Fukuhara, M., Kobayashi, K., Sadoshima, S., Hasuo, K. & Fujishima, M., Jun 1 1993, In : Journal of human hypertension. 7, 3, p. 309-310 2 p.

Research output: Contribution to journalLetter

Cerebral Infarction
Circadian Rhythm
Blood Pressure
Hypertension
4 Citations (Scopus)

CIRCADIAN VARIATIONS OF BLOOD PRESSURE AND PULSE RATE IN ESSENTIAL HYPERTENSIVES WITH DIABETES MELLITUS

Matsumura, K., Abe, I., Tsuchihashi, T., Kobayashi, K. & Fujishima, M., Jan 1 1993, In : Clinical and Experimental Pharmacology and Physiology. 20, 3, p. 155-160 6 p.

Research output: Contribution to journalArticle

Diabetes Mellitus
Heart Rate
Blood Pressure
Orthostatic Hypotension
Circadian Rhythm
5 Citations (Scopus)

Invasive Development of Right Atrial Myxoma— A Case Report

Nakayama, M., Matsumura, K., Abe, I., Kaku, R., Kobayashi, K., Fujishima, M., Aso, H., Tokunaga, K. & Ishii, Y., Jan 1 1993, In : Angiology. 44, 9, p. 739-744 6 p.

Research output: Contribution to journalArticle

Myxoma
Heart Atria
Brachiocephalic Veins
Superior Vena Cava
Thrombosis
2 Citations (Scopus)

In vivo effect of 7,8-benzoflavone on aryl hydrocarbon hydroxylase activity of mouse liver microsomes

Kiyohara, C. & Tomio, H., Jan 1 1993, In : Toxicology Letters. 66, 2, p. 199-207 9 p.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Hydroxylases
Methylcholanthrene
Liver Microsomes
Liver
Dichlorodiphenyldichloroethane
16 Citations (Scopus)

K channel openers activate different K channels in vascular smooth muscle cells

Kitamura, K. & Kamouchi, M., Aug 1 1993, In : Cardiovascular Drugs and Therapy. 7, 3 Supplement, p. 539-546 8 p.

Research output: Contribution to journalArticle

Portal Vein
Vascular Smooth Muscle
Smooth Muscle Myocytes
Rabbits
Glyburide
5 Citations (Scopus)

Lecture: Effects of Hypertension on Cerebral Blood Vessels

Heistad, D. D., Baumbach, G. L., Kitazono, T. & Faraci, F. M., Jan 1 1993, In : Hypertension Research. 16, 4, p. 225-231 7 p.

Research output: Contribution to journalArticle

Blood Vessels
Hypertension
Cerebrovascular Circulation
KATP Channels
Arterioles

Methyl alcohol poisoning

Inoue, N., Omura, M. & Hirata, M., Jan 1 1993, In : Fukuoka igaku zasshi = Hukuoka acta medica. 84, 2, p. 37-42 6 p.

Research output: Contribution to journalReview article

X Ray Computed Tomography
Hematologic Tests
Poisoning
Methanol
Central Nervous System
122 Citations (Scopus)

Role of ATP-sensitive K+ channels in CGRP-induced dilatation of basilar artery in vivo

Kitazono, T., Heistad, D. D. & Faraci, F. M., Sep 22 1993, In : American Journal of Physiology - Heart and Circulatory Physiology. 265, 2 34-2

Research output: Contribution to journalArticle

Basilar Artery
Calcitonin Gene-Related Peptide
Dilatation
Adenosine Triphosphate
Vasodilation
2 Citations (Scopus)

Synergism between muramyl dipeptide and lipopolysaccharide in the inhibition of glycosaminoglycan synthesis in cultured rat costal chondrocytes

Ikebe, T., Hirata, M., Yanaga, F. & Koga, T., Jan 1 1993, In : Annals of the Rheumatic Diseases. 52, 1, p. 32-36 5 p.

Research output: Contribution to journalArticle

Acetylmuramyl-Alanyl-Isoglutamine
Chondrocytes
Glycosaminoglycans
Lipopolysaccharides
Rats
3 Citations (Scopus)

The acute toxicity of allyl chloride by subcutaneous injection in mice.

Omura, M., Itonaga, Y., Komatsu, H., Mangen, Z., Hirata, M., Tanaka, A. & Inoue, N., Jan 1 1993, In : Fukuoka igaku zasshi = Hukuoka acta medica. 84, 10, p. 427-432 6 p.

Research output: Contribution to journalArticle

Leydig Cells
Subcutaneous Injections
Necrosis
Kidney Tubules
Inbred ICR Mouse
6 Citations (Scopus)

Transfection of interferon-γ gene in a mouse bone marrow stromal preadipocyte cell line causes apoptotic cell death

Nakano, T., Otsuka, T., Ogo, T., Niiro, H., Kuga, S., Zipori, D., Furukawa, Y. & Niho, Y., Dec 1 1993, In : Experimental Hematology. 21, 11, p. 1498-1503 6 p.

Research output: Contribution to journalArticle

Mesenchymal Stromal Cells
Interferons
Transfection
Cell Death
Cell Line
1992
7 Citations (Scopus)

Activation of cultured bovine aortic endothelial cells by extracellular pyrimidine triphosphate

Kitazono, T., Koichiro, T. & Shigeki, M., Jan 1 1992, In : International Journal of Biochemistry. 24, 8, p. 1323-1327 5 p.

Research output: Contribution to journalArticle

Endothelial cells
Endothelial Cells
Uridine Triphosphate
Adenosine Triphosphate
Chemical activation

Central effect of μ and δ opioids on neurohormonal and baroreflex regulation in conscious rabbits

Matsumura, K., Abe, I., Tsuchihashi, T., Tominaga, M., Kobayashi, K. & Fujishima, M., Jan 1 1992, In : Therapeutic Research. 13, 1, p. 212-217 6 p.

Research output: Contribution to journalArticle

Baroreflex
Opioid Analgesics
Rabbits
1 Citation (Scopus)

Comparison of suppression of mutagenicity of benzo(a)pyrene among methylsulfonyl polychlorinated biphenyl isomers

Kiyohara, C., Omura, M., Hirohata, T. & Masuda, Y., Jun 1 1992, In : Bulletin of Environmental Contamination and Toxicology. 48, 6, p. 877-883 7 p.

Research output: Contribution to journalArticle

Benzoflavones
Mutagenicity Tests
Aryl Hydrocarbon Hydroxylases
Benzo(a)pyrene
mutagenicity
16 Citations (Scopus)

Differential modulation by μ- and θ-opioids on baroreceptor reflex in conscious rabbits

Matsumura, K., Abe, I., Tominaga, M., Tsuchihashi, T., Kobayashi, K. & Fujishima, M., Jan 1 1992, In : Hypertension. 19, 6, p. 648-652 5 p.

Research output: Contribution to journalArticle

Baroreflex
Opioid Analgesics
Enkephalins
Rabbits
Naloxone
37 Citations (Scopus)

Epstein-Barr virus BCRF1 gene product (viral interleukin 10) inhibits superoxide anion production by human monocytes

Niiro, H., Otsuka, T., Abe, M., Satoh, H., Ogo, T., Nakano, T., Furukawa, Y. & Niho, Y., Jan 1 1992, In : Lymphokine and Cytokine Research. 11, 5, p. 209-214 6 p.

Research output: Contribution to journalArticle

Viral Proteins
Human Herpesvirus 4
Superoxides
Interleukin-10
Monocytes

In vitro/in vivo effects of 7,8-benzoflavone on aryl hydrocarbon hydroxylase activity of mice.

Kiyohara, C. & Hirohata, T., Jan 1 1992, In : Veterinary and human toxicology. 34, 5, p. 413-416 4 p.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Hydroxylases
unspecific monooxygenase
tetrachlorodibenzo-p-dioxin
Methylcholanthrene
mice

Ion transport system in the smooth muscle and hypertension

Suzuki, S., Kamouchi, M. & Kuriyama, H., Jan 1 1992, In : Nippon rinsho. Japanese journal of clinical medicine. 50 Suppl, p. 422-429 8 p.

Research output: Contribution to journalReview article

Active Biological Transport
Ion Transport
Calcium Channels
Vascular Smooth Muscle
Smooth Muscle
38 Citations (Scopus)

Signal transduction by tumor necrosis factor α is mediated through a guanine nucleotide-binding protein in osteoblast-like cell line, MC3T3-E1

Yanaga, F., Abe, M., Koga, T. & Hirata, M., Jan 1 1992, In : Journal of Biological Chemistry. 267, 8, p. 5114-5121 8 p.

Research output: Contribution to journalArticle

Signal transduction
Guanine Nucleotides
Osteoblasts
Signal Transduction
Carrier Proteins
54 Citations (Scopus)

Tumor necrosis factor α stimulates sphingomyelinase through the 55 kDa receptor in HL-60 cells

Takahashi, F. & Watson, S. P., Dec 21 1992, In : FEBS Letters. 314, 3, p. 297-300 4 p.

Research output: Contribution to journalArticle

Sphingomyelin Phosphodiesterase
HL-60 Cells
Sphingomyelins
Hydrolysis
Tumor Necrosis Factor-alpha