Department of Medical Education

Research Output 1983 2020

1998
20 Citations (Scopus)

Role of tyrosine kinase in dilator responses of rat basilar artery in vivo

Kitazono, T., Ibayashi, S., Nagao, T., Fujii, K., Kagiyama, T. & Fujishima, M., Mar 1998, In : Hypertension. 31, 3, p. 861-865 5 p.

Research output: Contribution to journalArticle

Basilar Artery
Protein-Tyrosine Kinases
Acetylcholine
Vasodilation
Bradykinin
19 Citations (Scopus)

Role of tyrosine kinase in serotonin-induced constriction of the basilar artery in vivo

Kitazono, T., Ibayashi, S., Nagao, T., Kagiyama, T., Kitayama, J. & Fujishima, M., Feb 1998, In : Stroke. 29, 2, p. 494-498 5 p.

Research output: Contribution to journalArticle

Basilar Artery
Constriction
Protein-Tyrosine Kinases
Serotonin
Vasoconstriction
20 Citations (Scopus)

Studies on the endothelin-1-induced contraction of rat granulation tissue pouch mediated by myofibroblasts

Goto, T., Yanaga, F. & Ohtsuki, I., Oct 21 1998, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1405, 1-3, p. 55-66 12 p.

Research output: Contribution to journalArticle

Myofibroblasts
Granulation Tissue
Endothelin-1
Croton Oil
Fura-2
77 Citations (Scopus)

The relationship between CYP1A1 aryl hydrocarbon hydroxylase activity and lung cancer in a Japanese population

Kiyohara, C., Nakanishi, Y., Inutsuka, S., Takayama, K., Hara, N., Motohiro, A., Tanaka, K., Kono, S. & Hirohata, T., Aug 24 1998, In : Pharmacogenetics. 8, 4, p. 315-323 9 p.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Hydroxylases
Cytochrome P-450 CYP1A1
Lung Neoplasms
Genotype
Population
1999
1 Citation (Scopus)

A new aspect of arsenic, an old poison

Hirata, M., Sep 1999, In : Fukuoka igaku zasshi = Hukuoka acta medica. 90, 9, p. 347-352 6 p.

Research output: Contribution to journalArticle

Arsenic Poisoning
Poisons
Arsenic
445 Citations (Scopus)

An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of β-catenin

Kitagawa, M., Hatakeyama, S., Shirane, M., Matsumoto, M., Ishida, N., Hattori, K., Nakamichi, I., Kikuchi, A., Nakayama, K. I. & Nakayama, K., May 4 1999, In : EMBO Journal. 18, 9, p. 2401-2410 10 p.

Research output: Contribution to journalArticle

F-Box Proteins
Proteolysis
Catenins
Ubiquitin
Ubiquitination
1 Citation (Scopus)

Angiotensin II receptor antagonists as the agents to treat cerebrovascular disease

Kitazono, T. & Fujishima, M., May 1999, In : Nippon rinsho. Japanese journal of clinical medicine. 57, 5, p. 1168-1175 8 p.

Research output: Contribution to journalReview article

Cerebrovascular Disorders
Angiotensin Receptor Antagonists
Renin-Angiotensin System
Angiotensin II
Cerebrovascular Circulation
66 Citations (Scopus)

Antagonistic effects of an alternative splice variant of human IL-4, IL- 4δ2, on IL-4 activities in human monocytes and B cells

Arinobu, Y., Atamas, S. P., Otsuka, T., Niiro, H., Yamaoka, K., Mitsuyasu, H., Niho, Y., Hamasaki, N., White, B. & Izuhara, K., Feb 1 1999, In : Cellular Immunology. 191, 2, p. 161-167 7 p.

Research output: Contribution to journalArticle

Human Activities
Interleukin-4
Monocytes
B-Lymphocytes
Cytokines
9 Citations (Scopus)

Antisense inhibition of angiotensinogen attenuates vasopressin release in the paraventricular hypothalamic nucleus of spontaneously hypertensive rats

Kagiyama, S., Tsuchihashi, T., Abe, I., Matsumura, K. & Fujishima, M., May 22 1999, In : Brain Research. 829, 1-2, p. 120-124 5 p.

Research output: Contribution to journalArticle

Angiotensinogen
Paraventricular Hypothalamic Nucleus
Antisense Oligonucleotides
Inbred SHR Rats
Vasopressins
53 Citations (Scopus)

Association of the interferon-γ receptor variant (Val14Met) with systemic lupus erythematosus

Tanaka, Y., Nakashima, H., Hisano, C., Kohsaka, T., Nemoto, Y., Niiro, H., Otsuka, T., Otsuka, T., Imamura, T. & Niho, Y., Mar 18 1999, In : Immunogenetics. 49, 4, p. 266-271 6 p.

Research output: Contribution to journalArticle

Interferon Receptors
Systemic Lupus Erythematosus
HLA-DR Antigens
B-Lymphocytes
Th1-Th2 Balance
90 Citations (Scopus)

Ca2+ sensitization and potentiation of the maximum level of myofibrillar ATPase activity caused by mutations of troponin T found in familial hypertrophic cardiomyopathy

Yanaga, F., Morimoto, S. & Ohtsuki, I., Mar 26 1999, In : Journal of Biological Chemistry. 274, 13, p. 8806-8812 7 p.

Research output: Contribution to journalArticle

Familial Hypertrophic Cardiomyopathy
Troponin T
Adenosine Triphosphatases
Mutation
Troponin
22 Citations (Scopus)

Central adrenomedullin augments the baroreceptor reflex in conscious rabbits

Matsumura, K., Abe, I., Tsuchihashi, T. & Fujishima, M., Apr 1999, In : Hypertension. 33, 4, p. 992-997 6 p.

Research output: Contribution to journalArticle

Adrenomedullin
Baroreflex
Intraventricular Infusions
Rabbits
Calcitonin Gene-Related Peptide
24 Citations (Scopus)

Differential effects of interleukin-4 and interleukin-10 on nitric oxide production by murine macrophages

Nemoto, Y., Otsuka, T., Niiro, H., Izuhara, K., Yamaoka, K., Nakashima, H. & Niho, Y., Dec 1 1999, In : Inflammation Research. 48, 12, p. 643-650 8 p.

Research output: Contribution to journalArticle

Interleukin-4
Interleukin-10
Nitric Oxide
Macrophages
Peritoneal Macrophages
210 Citations (Scopus)

Down-regulation of p27(Kip1) by two mechanisms, ubiquitin-mediated degradation and proteolytic processing

Shirane, M., Harumiya, Y., Ishida, N., Hirai, A., Miyamoto, C., Hatakeyama, S., Nakayama, K. I. & Kitagawa, M., May 14 1999, In : Journal of Biological Chemistry. 274, 20, p. 13886-18893 5008 p.

Research output: Contribution to journalArticle

Ubiquitin
Down-Regulation
Ubiquitination
Degradation
Processing
24 Citations (Scopus)

Effects of chronic oral treatment with imidapril and TCV-116 on the responsiveness to angiotensin II in ventrolateral medulla of SHR

Tsuchihashi, T., Kagiyama, S., Matsumura, K., Abe, I. & Fujishima, M., Jul 21 1999, In : Journal of hypertension. 17, 7, p. 917-922 6 p.

Research output: Contribution to journalArticle

Inbred SHR Rats
Angiotensin II
Inbred WKY Rats
Brain Stem
Angiotensin II Type 1 Receptor Blockers
11 Citations (Scopus)

Effects of interferon on circadian changes in blood pressure and heart rate variability in patients with chronic hepatitis

Fukuhara, M., Matsumura, K., Ohmori, S., Yanai, T., Tsubota, Y., Abe, I. & Fujishima, M., May 1 1999, In : American Journal of Hypertension. 12, 5, p. 519-523 5 p.

Research output: Contribution to journalArticle

Chronic Hepatitis
Interferons
Heart Rate
Blood Pressure
Body Temperature
36 Citations (Scopus)

Effects of missense mutations Phe110Ile and Glu244Asp in human cardiac troponin T on force generation in skinned cardiac muscle fibers

Nakaura, H., Yanaga, F., Ohtsuki, I. & Morimoto, S., Jan 1 1999, In : Journal of biochemistry. 126, 3, p. 457-460 4 p.

Research output: Contribution to journalArticle

Troponin T
Missense Mutation
Muscle
Myocardium
Mutation
36 Citations (Scopus)

Expression of p53 and glutathione S-transferase-π relates to clinical drug resistance in non-small cell lung cancer

Nakanishi, Y., Kawasaki, M., Bai, F., Takayama, K., Pei, X. H., Takano, K., Inoue, K., Osaki, S. I., Hara, N. & Kiyohara, C., Nov 1999, In : Oncology. 57, 4, p. 318-323 6 p.

Research output: Contribution to journalArticle

Glutathione Transferase
Drug Resistance
Non-Small Cell Lung Carcinoma
Drug Therapy
Logistic Models
42 Citations (Scopus)

Functional changes in troponin T by a splice donor site mutation that causes hypertrophic cardiomyopathy

Nakaura, H., Morimoto, S., Yanaga, F., Nakata, M., Nishi, H., Imaizumi, T. & Ohtsuki, I., Sep 11 1999, In : American Journal of Physiology - Cell Physiology. 277, 2 46-2, p. C225-C232

Research output: Contribution to journalArticle

Troponin T
RNA Splice Sites
Hypertrophic Cardiomyopathy
Mutation
Troponin I
36 Citations (Scopus)

Functional consequences of a carboxyl terminal missense mutation Arg278Cys in human cardiac troponin T

Morimoto, S., Nakaura, H., Yanaga, F. & Ohtsuki, I., Jul 22 1999, In : Biochemical and Biophysical Research Communications. 261, 1, p. 79-82 4 p.

Research output: Contribution to journalArticle

Troponin T
Missense Mutation
Muscle
Troponin
Fibers
4 Citations (Scopus)

Hepatitis G virus infection in a high-risk subgroup of hospitalized dental patients

Takata, Y., Tateishi, A., Kurokawa, H., Fujikawa, M., Matsumura, K., Wakisaka, M., Fukuda, J. & Kajiyama, M., Jan 1 1999, In : Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics. 87, 4, p. 442-445 4 p.

Research output: Contribution to journalArticle

GB virus C
Virus Diseases
Tooth
Hepatitis C Antibodies
Alanine Transaminase
65 Citations (Scopus)

Inverse association between coffee drinking and serum uric acid concentrations in middle-aged Japanese males

Kiyohara, C., Kono, S., Honjo, S., Todoroki, I., Sakurai, Y., Nishiwaki, M., Hamada, H., Nishikawa, H., Koga, H., Ogawa, S. & Nakagawa, K., Sep 2 1999, In : British Journal of Nutrition. 82, 2, p. 125-130 6 p.

Research output: Contribution to journalArticle

Coffee
Uric Acid
Drinking
Serum
Tea
97 Citations (Scopus)

Obesity, weight gain and risk of colon adenomas in Japanese men

Kono, S., Handa, K., Hayabuchi, H., Kiyohara, C., Inoue, H., Marugame, T., Shinomiya, S., Hamada, H., Onuma, K. & Koga, H., Aug 1999, In : Japanese Journal of Cancer Research. 90, 8, p. 805-811 7 p.

Research output: Contribution to journalArticle

Adenoma
Weight Gain
Colon
Obesity
Waist-Hip Ratio
16 Citations (Scopus)

Polymorphisms within the interleukin-10 receptor cDNA gene (IL10R) in Japanese patients with systemic lupus erythematosus

Nakashima, H., Akahoshi, M., Tanaka, Y., Yamaoka, K., Ogami, E., Nagano, S., Arinobu, Y., Niiro, H., Otsuka, T. & Niho, Y., Nov 1999, In : Rheumatology. 38, 11, p. 1142-1144 3 p.

Research output: Contribution to journalArticle

Interleukin-10 Receptors
Systemic Lupus Erythematosus
Complementary DNA
Genotype
Genes
23 Citations (Scopus)

Protective effects of hochu-ekki-to, a Chinese traditional herbal medicine against murine cytomegalovirus infection

Hossain, M. S., Takimoto, H., Hamano, S., Yoshida, H., Ninomiya, T., Minamishima, Y., Kimura, G. & Nomoto, K., Apr 1 1999, In : Immunopharmacology. 41, 3, p. 169-181 13 p.

Research output: Contribution to journalArticle

Muromegalovirus
Herbal Medicine
Chinese Traditional Medicine
Cytomegalovirus Infections
Natural Killer Cells
2 Citations (Scopus)

Relationship between aromatic-DNA adduct levels and inducibility of the drug metabolizing enzyme aryl hydrocarbon hydroxylase in lymphocytes

Kiyohara, C., Ichiba, M., Zhang, J., Nakanishi, Y., Takayama, K., Hara, N. & Hirohata, T., Dec 1 1999, In : Medical Science Research. 27, 10, p. 651-655 5 p.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Hydroxylases
Lymphocytes
DNA Adducts
Enzymes
Polymorphism
7 Citations (Scopus)

Role of AT1 receptors in area postrema on baroreceptor reflex in spontaneously hypertensive rats

Matsumura, K., Averill, D. B. & Ferrario, C. M., Dec 11 1999, In : Brain Research. 850, 1-2, p. 166-172 7 p.

Research output: Contribution to journalArticle

Area Postrema
Angiotensin Type 1 Receptor
Baroreflex
Inbred SHR Rats
Heart Rate
2 Citations (Scopus)

Role of metabolic polymorphisms in lung carcinogenesis

Kiyohara, C. & Ohno, Y., Jan 1 1999, In : [Nippon kōshū eisei zasshi] Japanese journal of public health. 46, 4, p. 241-249 9 p.

Research output: Contribution to journalReview article

Lung Neoplasms
Carcinogenesis
Lung
Genotype
Cytochrome P-450 CYP1A1
16 Citations (Scopus)

Selective DNA-binding activity of interleukin-10-stimulated STAT molecules in human monocytes

Yamaoka, K., Otsuka, T., Niiro, H., Nakashima, H., Tanaka, Y., Nagano, S., Ogami, E., Niho, Y., Hamasaki, N. & Izuhara, K., Jul 27 1999, In : Journal of Interferon and Cytokine Research. 19, 6, p. 679-685 7 p.

Research output: Contribution to journalArticle

Interleukin-10
Interferons
Monocytes
DNA
Genetic Promoter Regions
26 Citations (Scopus)

Subtypes of metabotropic glutamate receptors in the nucleus of the solitary tract of rats

Matsumura, K., Tsuchihashi, T., Kagiyama, S., Abe, I. & Fujishima, M., Sep 25 1999, In : Brain Research. 842, 2, p. 461-468 8 p.

Research output: Contribution to journalArticle

Metabotropic Glutamate Receptors
Solitary Nucleus
Microinjections
Arterial Pressure
Kidney
228 Citations (Scopus)

Th1/Th2 balance of peripheral T helper cells in systemic lupus erythematosus

Akahoshi, M., Nakashima, H., Tanaka, Y., Kohsaka, T., Nagano, S., Ohgami, E., Arinobu, Y., Yamaoka, K., Niiro, H., Shinozaki, M., Hirakata, H., Horiuchi, T., Otsuka, T. & Niho, Y., Aug 1 1999, In : Arthritis and rheumatism. 42, 8, p. 1644-1648 5 p.

Research output: Contribution to journalArticle

Th1-Th2 Balance
Helper-Inducer T-Lymphocytes
Systemic Lupus Erythematosus
Th2 Cells
Lupus Nephritis
53 Citations (Scopus)

The combination of polymorphisms within interferon-γ receptor I and receptor 2 associated with the risk of systemic lupus erythematosus

Nakashima, H., Inoue, H., Akahoshi, M., Tanaka, Y., Yamaoka, K., Ogami, E., Nagano, S., Arinobu, Y., Niiro, H., Otsuka, T. & Niho, Y., Jun 18 1999, In : FEBS Letters. 453, 1-2, p. 187-190 4 p.

Research output: Contribution to journalArticle

Interferon Receptors
Polymorphism
Systemic Lupus Erythematosus
Amino Acids
Genotype
26 Citations (Scopus)

The transmembrane sequence of human histocompatibility leukocyte antigen (HLA)-C as a determinant in inhibition of a subset of natural killer cells

Davis, D. M., Mandelboim, O., Luque, I., Baba, E., Boyson, J. & Strominger, J. L., Apr 19 1999, In : Journal of Experimental Medicine. 189, 8, p. 1265-1274 10 p.

Research output: Contribution to journalArticle

Histocompatibility Antigens
HLA Antigens
Natural Killer Cells
Major Histocompatibility Complex
Clone Cells
2 Citations (Scopus)

Two polymorphisms within interleukin-3 (hlL3) gene detected by mismatch PCR/RFLP

Nakashima, H., Otsuka, T., Ohba, Y., Akahoshi, M., Nagano, S., Ogami, E., Arinobu, Y., Miyake, K., Inoue, Y., Niiro, H., Kaji, Y. & Niho, Y., Jan 1 1999, In : Genes and Immunity. 1, 2, p. 156-158 3 p.

Research output: Contribution to journalArticle

Interleukin-3
Nucleic Acid Databases
Restriction Fragment Length Polymorphisms
Thymine
Cytosine
2000
1 Citation (Scopus)

Calcium antagonist isradipine reduces metabolic alterations in acute cerebral ischemia in spontaneously hypertensive rats

Ibayashi, S., Nagao, T., Kitazono, T., Ooboshi, H., Kitayama, J., Sadoshima, S. & Fujishima, M., Apr 2 2000, In : Neurochemical Research. 25, 3, p. 349-355 7 p.

Research output: Contribution to journalArticle

Isradipine
Inbred SHR Rats
Brain Ischemia
Carotid Arteries
Ligation
12 Citations (Scopus)

Cardiovascular responses to glutamate and angiotensin II in ventrolateral medulla of hypertension induced by chronic inhibition of nitric oxide

Tsuchihashi, T., Kagiyama, S., Matsumura, K., Lin, Y., Abe, I. & Fujishima, M., Jul 2000, In : Hypertension Research. 23, 4, p. 359-364 6 p.

Research output: Contribution to journalArticle

Open Access
NG-Nitroarginine Methyl Ester
Angiotensin II
Glutamic Acid
Nitric Oxide
Hypertension
4 Citations (Scopus)

Cardiovascular response to dental treatment with use of local anesthesia

Matsumura, K., Miura, K., Takata, Y., Abe, I. & Fujishima, M., Jan 1 2000, In : Cardiovascular Reviews and Reports. 21, 1, p. 35-39 5 p.

Research output: Contribution to journalReview article

Local Anesthesia
Tooth
Blood Pressure
Heart Rate
Sympathetic Nervous System
32 Citations (Scopus)

Central cardiovascular action of neuropeptide Y in conscious rabbits

Matsumura, K., Tsuchihashi, T. & Abe, I., Jan 1 2000, In : Hypertension. 36, 6, p. 1040-1044 5 p.

Research output: Contribution to journalArticle

Neuropeptide Y
Rabbits
Kidney
Leptin
Baroreflex
76 Citations (Scopus)

Central effects of leptin on cardiovascular and neurohormonal responses in conscious rabbits

Matsumura, K., Abe, I., Tsuchihashi, T. & Fujishima, M., Jun 27 2000, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 278, 5 47-5, p. R1314-R1320

Research output: Contribution to journalArticle

Leptin
Rabbits
Injections
Arterial Pressure
Kidney
11 Citations (Scopus)

Central infusion of L-arginine or superoxide dismutase does not alter arterial pressure in SHR

Kagiyama, S., Tsuchihashi, T., Abe, I., Matsumura, K. & Fujishima, M., Jul 2000, In : Hypertension Research. 23, 4, p. 339-343 5 p.

Research output: Contribution to journalArticle

Open Access
Inbred SHR Rats
Superoxide Dismutase
Arginine
Arterial Pressure
NG-Nitroarginine Methyl Ester

Cerebrovascular diseases

Kamouchi, M. & Fujishima, M., Jan 2000, In : Nippon rinsho. Japanese journal of clinical medicine. 58 Suppl 1, p. 714-719 6 p.

Research output: Contribution to journalReview article

Cerebrovascular Disorders
Hypertension
29 Citations (Scopus)

Changes in the testicular damage caused by indium arsenide and indium phosphide in hamsters during two years after intratracheal instillations

Omura, M., Yamazaki, K., Tanaka, A., Hirata, M., Makita, Y. & Inoue, N., Jan 1 2000, In : Journal of Occupational Health. 42, 4, p. 196-204 9 p.

Research output: Contribution to journalArticle

Indium
Cricetinae
Spermatogonia
Semiconductors
Body Weight
14 Citations (Scopus)

Characterization of CD4- CD8- CD3+ T-cell receptor-αβ+ T cells in murine cytomegalovirus infection

Hossain, M. S., Takimoto, H., Ninomiya, T., Yoshida, H., Kishihara, K., Matsuzaki, G., Kimura, G. & Nomoto, K., Jan 1 2000, In : Immunology. 101, 1, p. 19-29 11 p.

Research output: Contribution to journalArticle

Muromegalovirus
Cytomegalovirus Infections
T-Cell Antigen Receptor
T-Lymphocytes
Interferons
49 Citations (Scopus)

Cigarette smoking, CYP1A1 MspI and GSTM1 genotypes, and colorectal adenomas

Inoue, H., Kiyohara, C., Marugame, T., Shinomiya, S., Tsuji, E., Handa, K., Hayabuchi, H., Onuma, K., Hamada, H., Koga, H. & Kono, S., Jul 15 2000, In : Cancer Research. 60, 14, p. 3749-3752 4 p.

Research output: Contribution to journalArticle

Cytochromes
Adenoma
Smoking
Genotype
Polycyclic Aromatic Hydrocarbons
23 Citations (Scopus)

Comparative study of the toxic effects of gallium arsenide, indium arsenide and arsenic trioxide following intratracheal instillations to the lung of syrian golden hamsters

Tanaka, A., Hirata, M., Omura, M., Zhao, M., Makita, Y., Yamazaki, K., Inoue, N. & Gotoh, K., Mar 23 2000, In : Fukuoka Acta Medica. 91, 1, p. 21-33 13 p.

Research output: Contribution to journalArticle

Poisons
Mesocricetus
Cricetinae
Lung
Epithelial Cells

Double blind study of the effect of caffeine on the mental calculation

Shiraishi, F., Takahashi, F., Goto, T., Harada, K., Kusaba, A. & Morimoto, S., Jul 12 2000, In : Fukuoka Acta Medica. 91, 4, p. 100-103 4 p.

Research output: Contribution to journalArticle

Clinical Pharmacology
Caffeine
Medical Schools
Double-Blind Method
Exercise
17 Citations (Scopus)

Effect of Arg145Gly mutation in human cardiac troponin I on the ATPase activity of cardiac myofibrils

Takahashi-Yanaga, F., Morimoto, S. & Ohtsuki, I., Jan 1 2000, In : Journal of biochemistry. 127, 3, p. 355-357 3 p.

Research output: Contribution to journalArticle

Troponin I
Myofibrils
Adenosine Triphosphatases
Mutation
Troponin C
25 Citations (Scopus)

Effect of selective brain hypothermia on regional cerebral blood flow and tissue metabolism using brain thermo-regulator in spontaneously hypertensive rats

Ibayashi, S., Takano, K., Ooboshi, H., Kitazono, T., Sadoshima, S. & Fujishima, M., Apr 2 2000, In : Neurochemical Research. 25, 3, p. 369-375 7 p.

Research output: Contribution to journalArticle

Cerebrovascular Circulation
Hypothermia
Regional Blood Flow
Inbred SHR Rats
Metabolism

Erratum: Effect of Arg145Gly mutation in human cardiac troponin I on the ATPase activity of cardiac myofibrils (Journal of Biochemistry (2000) 127:3 (355-357))

Takahashi-Yanaga, F., Morimoto, S. & Ohtsuki, I., Jan 1 2000, In : Journal of biochemistry. 128, 3, 1 p.

Research output: Contribution to journalComment/debate

Biochemistry
Troponin I
Myofibrils
Adenosine Triphosphatases
Mutation
37 Citations (Scopus)

Functional consequences of the deletion mutation ΔGlu160 in human cardiac troponin T

Harada, K., Takahashi-Yanaga, F., Minakami, R., Morimoto, S. & Ohtsuki, I., Jan 1 2000, In : Journal of biochemistry. 127, 2, p. 263-268 6 p.

Research output: Contribution to journalArticle

Troponin T
Sequence Deletion
Troponin C
Troponin
Troponin I