Department of Medical Education

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Novel Regulatory Mechanisms of CD40-Induced Prostanoid Synthesis by IL-4 and IL-10 in Human Monocytes

Inoue, Y., Otsuka, T., Niiro, H., Nagano, S., Arinobu, Y., Ogami, E., Akahoshi, M., Miyake, K., Ninomiya, I., Shimizu, S., Nakashima, H. & Harada, M., Feb 15 2004, In : Journal of Immunology. 172, 4, p. 2147-2154 8 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Novel therapeutic strategies targeting innate immune responses and early inflammation after stroke

Shichita, T., Ago, T., Kamouchi, M., Kitazono, T., Yoshimura, A. & Ooboshi, H., Nov 1 2012, In : Journal of Neurochemistry. 123, SUPPL. 2, p. 29-38 10 p.

Research output: Contribution to journalArticle

97 Citations (Scopus)

Nox4 as the Major Catalytic Component of an Endothelial NAD(P)H Oxidase

Ago, T., Kitazono, T., Ooboshi, H., Iyama, T., Han, Y. H., Takada, J., Wakisaka, M., Ibayashi, S., Utsumi, H. & Iida, M., Jan 20 2004, In : Circulation. 109, 2, p. 227-233 7 p.

Research output: Contribution to journalArticle

405 Citations (Scopus)

Nox4 is a major source of superoxide production in human brain pericytes

Kuroda, J., Ago, T., Nishimura, A., Nakamura, K., Matsuo, R., Wakisaka, Y., Kamouchi, M. & Kitazono, T., Mar 6 2014, In : Journal of Vascular Research. 51, 6, p. 429-438 10 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

Nox4 Promotes Neural Stem/Precursor Cell Proliferation and Neurogenesis in the Hippocampus and Restores Memory Function Following Trimethyltin-Induced Injury

Yoshikawa, Y., Ago, T., Kuroda, J., Wakisaka, Y., Tachibana, M., Komori, M., Shibahara, T., Nakashima, H., Nakashima, K. & Kitazono, T., Feb 1 2019, In : Neuroscience. 398, p. 193-205 13 p.

Research output: Contribution to journalArticle

N-terminal pro-brain natriuretic peptide and risk of cardiovascular events in a Japanese community: The hisayama study

Doi, Y., Ninomiya, T., Hata, J., Hirakawa, Y., Mukai, N., Ikeda, F., Fukuhara, M., Iwase, M. & Kiyohara, Y., Dec 1 2011, In : Arteriosclerosis, thrombosis, and vascular biology. 31, 12, p. 2997-3003 7 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)
Open Access

Obesity, weight gain and risk of colon adenomas in Japanese men

Kono, S., Handa, K., Hayabuchi, H., Kiyohara, C., Inoue, H., Marugame, T., Shinomiya, S., Hamada, H., Onuma, K. & Koga, H., Aug 1999, In : Japanese Journal of Cancer Research. 90, 8, p. 805-811 7 p.

Research output: Contribution to journalArticle

97 Citations (Scopus)
Open Access
9 Citations (Scopus)

Occupational risk factors for Parkinson's disease: A case-control study in Japan

Tanaka, K., Miyake, Y., Fukushima, W., Sasaki, S., Kiyohara, C., Tsuboi, Y., Yamada, T., Oeda, T., Miki, T., Kawamura, N., Sakae, N., Fukuyama, H., Hirota, Y. & Nagai, M., Jul 7 2011, In : BMC neurology. 11, 83.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Onset of reversible flaccid quadriplegia during treatment of thyrotoxic crisis

Mizokam, T., Fukui, T., Imoto, H., Fujii, H., Sato, Y., Nunoi, K. & Okamura, K., Jan 1 2015, In : Internal Medicine. 54, 4, p. 421-425 5 p.

Research output: Contribution to journalArticle

Onset of spermatogenesis is accelerated by gestational administration of 1,2,3,4,6,7-hexachlorinated naphthalene in male rat offspring

Omura, M., Masuda, Y., Hirata, M., Tanaka, A., Makita, Y., Ogata, R. & Inoue, N., Jan 1 2000, In : Environmental Health Perspectives. 108, 6, p. 539-544 6 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Opioids modulate cardiovascular and neurohormonal responses to intracerebroventricular injection of endothelin in conscious rabbits

Matsumura, K., Abe, I., Tsuchihashi, T., Tominaga, M., Kobayashi, K. & Fujishima, M., Dec 1 1990, In : Therapeutic Research. 11, 12, p. 105-110 6 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Opposing actions of angiotensin-(1-7) and angiotensin II in the brain of transgenic hypertensive rats

Moriguchi, A., Tallant, E. A., Matsumura, K., Reilly, T. M., Walton, H., Ganten, D. & Ferrario, C. M., Jun 1995, In : Hypertension. 25, 6, p. 1260-1265 6 p.

Research output: Contribution to journalArticle

86 Citations (Scopus)

Optimal cutoff value of the serum pepsinogen level for prediction of gastric cancer incidence: The Hisayama Study

Shikata, K., Ninomiya, T., Yonemoto, K., Ikeda, F., Hata, J., Doi, Y., Fukuhara, M., Matsumoto, T., Iida, M., Kitazono, T. & Kiyohara, Y., Jun 1 2012, In : Scandinavian Journal of Gastroenterology. 47, 6, p. 669-675 7 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Oral mycobiome in community-dwelling elderly and its relation to oral and general health conditions

Zakaria, M. N., Furuta, M., Takeshita, T., Shibata, Y., Sundari, R., Eshima, N., Ninomiya, T. & Yamashita, Y., Oct 2017, In : Oral Diseases. 23, 7, p. 973-982 10 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Organ-dependent T-cell subset requirement in defense against virus in mice acutely and systemically infected with murine cytomegalovirus

Kimura, G., Takimoro, H., Yoshida, H., Ninomiya, T., Nukina, H., Ohtsu, M. & Nomoto, K., Jan 1 2000, In : Biomedical Research. 21, 2, p. 111-115 5 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Orthopaedic registries with patient-reported outcome measures

Wilson, I., Bohm, E., Lübbeke, A., Lyman, S., Overgaard, S., Rolfson, O., W-Dahl, A., Wilkinson, M. & Dunbar, M., Jun 1 2019, In : EFORT Open Reviews. 4, 6, p. 357-367 11 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Orthostatic hypotension predicts a poor prognosis in elderly people with dementia

Oishi, E., Sakata, S., Tsuchihashi, T., Tominaga, M. & Fujii, K., Jan 1 2016, In : Internal Medicine. 55, 15, p. 1947-1952 6 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Outcome prediction in acute stroke patients by continuous glucose monitoring

Wada, S., Yoshimura, S., Inoue, M., Matsuki, T., Arihiro, S., Koga, M., Kitazono, T., Makino, H., Hosoda, K., Ihara, M. & Toyoda, K., Apr 17 2018, In : Journal of the American Heart Association. 7, 8, e008744.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Outcomes associated with carotid pseudo-occlusion

Ogata, T., Yasaka, M., Kanazawa, Y., Wakugawa, Y., Inoue, T., Yasumori, K., Kitazono, T. & Okada, Y., Apr 1 2011, In : Cerebrovascular Diseases. 31, 5, p. 494-498 5 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Outcomes associated with under-dosing of rivaroxaban for management of non-valvular atrial fibrillation in real-world Japanese clinical settings

Ikeda, T., Ogawa, S., Kitazono, T., Nakagawara, J., Minematsu, K., Miyamoto, S., Murakawa, Y., Iwashiro, S., Kidani, Y., Okayama, Y., Sunaya, T., Sato, S. & Yamanaka, S., Nov 1 2019, In : Journal of Thrombosis and Thrombolysis. 48, 4, p. 653-660 8 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Overexpression of mth1 and ogg1 proteins in ulcerative colitis-associated carcinogenesis

Kumagae, Y., Hirahashi, M., Takizawa, K., Yamamoto, H., Gushima, M., Esaki, M., Matsumoto, T., Nakamura, M., Kitazono, T. & Oda, Y., Aug 2018, In : Oncology Letters. 16, 2, p. 1765-1776 12 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Overview of BioBank Japan follow-up data in 32 diseases

Biobank Japan Cooperative Hospital Group, Jan 1 2017, In : Journal of epidemiology. 27, 3, p. S22-S28

Research output: Contribution to journalArticle

24 Citations (Scopus)

Overview of the BioBank Japan Project: Study design and profile

Biobank Japan Cooperative Hospital Group, Jan 1 2017, In : Journal of epidemiology. 27, 3, p. S2-S8

Research output: Contribution to journalArticle

79 Citations (Scopus)

Oxaliplatin induces mitotic catastrophe and apoptosis in esophageal cancer cells

Ngan, C. Y., Yamamoto, H., Takagi, A., Fujie, Y., Takemasa, I., Ikeda, M., Takahashi-Yanaga, F., Sasaguri, T., Sekimoto, M., Matsuura, N. & Monden, M., Jan 1 2008, In : Cancer Science. 99, 1, p. 129-139 11 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)

p40phox as an alternative organizer to p47phox in Nox2 activation: A new mechanism involving an interaction with p22phox

Tamura, M., Shiozaki, I., Ono, S., Miyano, K., Kunihiro, S. & Sasaki, T., Sep 18 2007, In : FEBS Letters. 581, 23, p. 4533-4538 6 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Paradoxical Brain Embolism in Elderly Subjects with Small Atrial Septal Defects

Kitamura, T., Arakawa, S., Murao, K., Kitazono, T. & Ago, T., Jul 2018, In : Journal of Stroke and Cerebrovascular Diseases. 27, 7, p. 1987-1991 5 p.

Research output: Contribution to journalArticle

PARK16 polymorphisms, interaction with smoking, and sporadic Parkinson's disease in Japan

Fukuoka Kinki Parkinson's Disease Study Group, Mar 15 2016, In : Journal of the Neurological Sciences. 362, p. 47-52 6 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Patellofemoral crepitation and clunk following modern, fixed-bearing total knee arthroplasty

Peralta-Molero, J. V., Gladnick, B. P., Lee, Y. Y., Ferrer, A. V., Lyman, S. & González Della Valle, A., Mar 1 2014, In : Journal of Arthroplasty. 29, 3, p. 535-540 6 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
12 Citations (Scopus)

Pathogenetic mechanism of brain infarction

Kitazono, T., Apr 1 2016, In : Nihon rinsho. Japanese journal of clinical medicine. 74, 4, p. 546-548 3 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
4 Citations (Scopus)

Patient-reported outcome measures in arthroplasty registries: Report of the Patient-Reported Outcome Measures Working Group of the International Society of Arthroplasty RegistriesPart II. Recommendations for selection, administration, and analysis

Rolfson, O., Bohm, E., Franklin, P., Lyman, S., Denissen, G., Dawson, J., Dunn, J., Eresian Chenok, K., Dunbar, M., Overgaard, S., Garellick, G. & Lübbeke, A., Jun 15 2016, In : Acta Orthopaedica. 87, p. 9-23 15 p.

Research output: Contribution to journalArticle

61 Citations (Scopus)

Patient-reported outcome measures in arthroplasty registries: Report of the Patient-Reported Outcome Measures Working Group of the International Society of Arthroplasty Registries: Part I. Overview and rationale for patient-reported outcome measures

Rolfson, O., Eresian Chenok, K., Bohm, E., Lübbeke, A., Denissen, G., Dunn, J., Lyman, S., Franklin, P., Dunbar, M., Overgaard, S., Garellick, G. & Dawson, J., Jun 15 2016, In : Acta Orthopaedica. 87, p. 3-8 6 p.

Research output: Contribution to journalArticle

49 Citations (Scopus)
5 Citations (Scopus)

PDGF receptor β signaling in pericytes following ischemic brain injury

Arimura, K., Ago, T., Kamouchi, M., Nakamura, K., Ishitsuka, K., Kuroda, J., Sugimori, H., Ooboshi, H., Sasaki, T. & Kitazono, T., Feb 2012, In : Current Neurovascular Research. 9, 1, p. 1-9 9 p.

Research output: Contribution to journalArticle

62 Citations (Scopus)
3 Citations (Scopus)

Periodontal status and lung function decline in the community: the Hisayama study

Takeuchi, K., Matsumoto, K., Furuta, M., Fukuyama, S., Takeshita, T., Ogata, H., Suma, S., Shibata, Y., Shimazaki, Y., Hata, J., Ninomiya, T., Nakanishi, Y., Inoue, H. & Yamashita, Y., Dec 1 2018, In : Scientific reports. 8, 1, 13354.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Periodontitis Is Associated with Chronic Obstructive Pulmonary Disease

Takeuchi, K., Matsumoto, K., Furuta, M., Fukuyama, S., Takeshita, T., Ogata, H., Suma, S., Shibata, Y., Shimazaki, Y., Hata, J., Ninomiya, T., Nakanishi, Y., Inoue, H. & Yamashita, Y., May 1 2019, In : Journal of Dental Research. 98, 5, p. 534-540 7 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Perioperative blood pressure variability in the treated hypertensive patients

Kiyohara, K., Oniki, H., Tsuchihashi, T. & Matsumura, K., Jun 26 2013, In : Clinical and Experimental Hypertension. 35, 4, p. 291-294 4 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Periostin promotes the generation of fibrous membranes in proliferative vitreoretinopathy Keijiro Ishikawa1

Yoshida, S., Nakao, S., Nakama, T., Kita, T., Asato, R., Sassa, Y., Arita, R., Miyazaki, M., Enaida, H., Oshima, Y., Murakami, N., Niiro, H., Ono, J., Matsuda, A., Goto, Y., Akashi, K., Izuhara, K., Kudo, A., Kono, T., Hafezi-Moghadam, A. & 1 others, Ishibashi, T., Jan 2014, In : FASEB Journal. 28, 1, p. 131-142 12 p.

Research output: Contribution to journalArticle

41 Citations (Scopus)

Peripheral tolerance and the qualitative characteristics of autoreactive T cell clones in primary biliary cirrhosis

Kawano, A., Shimoda, S., Kamihira, T., Ishikawa, F., Niiro, H., Soejima, Y., Taketomi, A., Maehara, Y., Nakamura, M., Komori, A., Migita, K., Ishibashi, H., Azuma, M., Gershwin, M. E. & Harada, M., Sep 1 2007, In : Journal of Immunology. 179, 5, p. 3315-3324 10 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Peroxiredoxin family proteins are key initiators of post-ischemic inflammation in the brain

Shichita, T., Hasegawa, E., Kimura, A., Morita, R., Sakaguchi, R., Takada, I., Sekiya, T., Ooboshi, H., Kitazono, T., Yanagawa, T., Ishii, T., Takahashi, H., Mori, S., Nishibori, M., Kuroda, K., Akira, S., Miyake, K. & Yoshimura, A., Jun 1 2012, In : Nature medicine. 18, 6, p. 911-917 7 p.

Research output: Contribution to journalArticle

230 Citations (Scopus)

Personal indium exposure concentration in respirable dusts and serum indium level

Iwasawa, S., Nakano, M., Miyauchi, H., Tanaka, S., Kawasumi, Y., Higashikubo, I., Tanaka, A., Hirata, M. & Omae, K., Jan 1 2017, In : Industrial health. 55, 1, p. 87-90 4 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Pharmacokinetics Study of Low Dose of Metformin Clinically Used in Japan

Iwase, M., Nohara, S., Sasaki, N., Himeno, T., Nishida, M., Yoshinari, M., Yoshizumi, H., Mukai, N., Doi, Y., Morizono, S., Asano, T., Tsutsu, N. & Iida, M., May 19 2004, In : Journal of the Japan Diabetes Society. 47, 3, p. 197-201 5 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Phenylarsine oxide inhibits tyrosine phosphorylation of phospholipase Cγ2 in human platelets and phospholipase Cγ1 in NIH-3T3 fibroblasts

Yanaga, F., Asselin, J., Schieven, G. L. & Watson, S. P., Jul 17 1995, In : FEBS Letters. 368, 2, p. 377-380 4 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Phosphate Binders Prevent Phosphate-Induced Cellular Senescence of Vascular Smooth Muscle Cells and Vascular Calcification in a Modified, Adenine-Based Uremic Rat Model

Yamada, S., Tatsumoto, N., Tokumoto, M., Noguchi, H., Ooboshi, H., Kitazono, T. & Tsuruya, K., Mar 13 2015, In : Calcified Tissue International. 96, 4, p. 347-358 12 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Phosphate overload directly induces systemic inflammation and malnutrition as well as vascular calcification in uremia

Yamada, S., Tokumoto, M., Tatsumoto, N., Taniguchi, M., Noguchi, H., Nakano, T., Masutani, K., Ooboshi, H., Tsuruya, K. & Kitazono, T., Jun 15 2014, In : American Journal of Physiology - Renal Physiology. 306, 12, p. F1418-F1428

Research output: Contribution to journalArticle

70 Citations (Scopus)