Department of Medical Education

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2000

Effect of Arg145Gly mutation in human cardiac troponin I on the ATPase activity of cardiac myofibrils

Takahashi-Yanaga, F., Morimoto, S. & Ohtsuki, I., Jan 1 2000, In : Journal of biochemistry. 127, 3, p. 355-357 3 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Effect of selective brain hypothermia on regional cerebral blood flow and tissue metabolism using brain thermo-regulator in spontaneously hypertensive rats

Ibayashi, S., Takano, K., Ooboshi, H., Kitazono, T., Sadoshima, S. & Fujishima, M., Apr 2 2000, In : Neurochemical Research. 25, 3, p. 369-375 7 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Functional consequences of the deletion mutation ΔGlu160 in human cardiac troponin T

Harada, K., Takahashi-Yanaga, F., Minakami, R., Morimoto, S. & Ohtsuki, I., Jan 1 2000, In : Journal of biochemistry. 127, 2, p. 263-268 6 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

Genetic polymorphism of enzymes involved in xenobiotic metabolism and the risk of colorectal cancer

Kiyohara, C., Jan 1 2000, In : Journal of epidemiology. 10, 5, p. 349-360 12 p.

Research output: Contribution to journalArticle

72 Citations (Scopus)

Ineffective control of murine cytomegalovirus by IE1-specific cytotoxic T lymphocytes during protracted infection in the lung

Chen, Q. J., Yoshida, H., Takimoto, H., Ninomiya, T., Ohtsu, M., Kimura, G. & Nomoto, K., Jan 1 2000, In : Archives of Virology. 145, 7, p. 1291-1304 14 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Ischemic brain metabolism in patients with chronic cerebrovascular disease: Increased oxygen extraction fraction and cerebrospinal fluid lactate

Ibayashi, S., Irie, K., Kitayama, J., Nagao, T., Kitazono, T. & Fujishima, M., Jul 2000, In : Journal of Stroke and Cerebrovascular Diseases. 9, 4, p. 166-171 6 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Isolated dissection of the celiac artery: A case report

matsuo, R., Ohta, Y., Ohya, Y., Kitazono, T., Irie, H., Shikata, T., Abe, I. & Fujishima, M., Jan 1 2000, In : Angiology. 51, 7, p. 603-607 5 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)

Left ventricular mass predicted by a single reading of ambulatory blood pressure in essential hypertension

Ohmori, S., Matsumura, K., Kajioka, T., Fukuhara, M., Abe, I. & Fujishima, M., Jul 2000, In : Hypertension Research. 23, 4, p. 311-316 6 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Long term pulmonary toxicity of indium arsenide and indium phosphide instilled intratracheally in hamsters

Yamazaki, K., Tanaka, A., Hirata, M., Omura, M., Makita, Y., Inoue, N., Sugio, K. & Sugimachi, K., Jan 1 2000, In : Journal of Occupational Health. 42, 4, p. 169-178 10 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)

Lotharella amoeboformis sp. nov. A new species of chlorarachniophytes from Japan

Ishida, K. I., Ishida, N. & Hara, Y., Jan 1 2000, In : Phycological Research. 48, 4, p. 221-229 9 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Lung cancer risk and genetic polymorphism at the glutathione S-transferase P1 locus in male Japanese

Yamamura, K., Kiyohara, C., Nakanishi, Y., Takayama, K. & Hara, N., Aug 2000, In : Fukuoka igaku zasshi = Hukuoka acta medica. 91, 8, p. 203-206 4 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Metabotropic glutamate receptor subtypes involved in cardiovascular regulation in the rostral ventrolateral medulla of rats

Tsuchihashi, T., Liu, Y., Kagiyama, S., Matsumura, K., Abe, I. & Fujishima, M., Jul 1 2000, In : Brain Research Bulletin. 52, 4, p. 279-283 5 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Methylenetetrahydrofolate reductase polymorphism and risk of colorectal adenomas

Marugame, T., Tsuji, E., Inoue, H., Shinomiya, S., Kiyohara, C., Onuma, K., Hamada, H., Koga, H., Handa, K., Hayabuchi, H. & Kono, S., Apr 14 2000, In : Cancer Letters. 151, 2, p. 181-186 6 p.

Research output: Contribution to journalArticle

50 Citations (Scopus)

Onset of spermatogenesis is accelerated by gestational administration of 1,2,3,4,6,7-hexachlorinated naphthalene in male rat offspring

Omura, M., Masuda, Y., Hirata, M., Tanaka, A., Makita, Y., Ogata, R. & Inoue, N., Jan 1 2000, In : Environmental Health Perspectives. 108, 6, p. 539-544 6 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Organ-dependent T-cell subset requirement in defense against virus in mice acutely and systemically infected with murine cytomegalovirus

Kimura, G., Takimoro, H., Yoshida, H., Ninomiya, T., Nukina, H., Ohtsu, M. & Nomoto, K., Jan 1 2000, In : Biomedical Research. 21, 2, p. 111-115 5 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Phosphorylation at serine 10, a major phosphorylation site of p27(Kip1), increases its protein stability

Ishida, N., Kitagawa, M., Hatakeyama, S. & Nakayama, K., Aug 18 2000, In : Journal of Biological Chemistry. 275, 33, p. 25146-25154 9 p.

Research output: Contribution to journalArticle

173 Citations (Scopus)

Polymorphism in GSTM1, GSTT1, and GSTP1 and susceptibility to lung cancer in a Japanese population

Kiyohara, C., Yamamura, K. I., Nakanishi, Y., Takayama, K. & Hara, N., 2000, In : Asian Pacific Journal of Cancer Prevention. 1, 4, p. 293-298 6 p.

Research output: Contribution to journalArticle

41 Citations (Scopus)

Role of phosphatidylinositol 3-kinase in acetylcholine-induced dilatation of rat basilar artery

Kitayama, J., Kitazono, T., Ibayashi, S., Wakisaka, M., Watanabe, Y., Kamouchi, M., Nagao, T. & Fujishima, M., Jan 1 2000, In : Stroke. 31, 10, p. 2487-2493 7 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Roles of T Lymphocytes in Defense against Experimental Acute Pulmonary Infection of Mice with Murine Cytomegalovirus

Kimura, G., Takimoto, H., Yoshida, H., Ninomiya, T., Chen, Q., Ohtsu, M. & Nomoto, K., Jan 1 2000, In : Biomedical Research (Japan). 21, 5, p. 225-246 22 p.

Research output: Contribution to journalArticle

Suppression of cardiac sympathetic nervous system during dental surgery in hypertensive patients

Miura, K., Matsumura, K., Nakamura, Y., Kurokawa, H., Kajiyama, M. & Takata, Y., May 2000, In : Hypertension Research. 23, 3, p. 207-212 6 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Targeted disruption of Skp2 results in accumulation of cyclin E and p27 (Kip1), polyploidy and centrosome overduplication

Nakayama, K., Nagahama, H., Minamishima, Y. A., Matsumoto, M., Nakamichi, I., Kitagawa, K., Shirane, M., Tsunematsu, R., Tsukiyama, T., Ishida, N., Kitagawa, M., Nakayama, K. I. & Hatakeyama, S., May 2 2000, In : EMBO Journal. 19, 9, p. 2069-2081 13 p.

Research output: Contribution to journalArticle

592 Citations (Scopus)

The isolation of methicillin-resistant Staphylococcus aureus (MRSA) is a predictor for poor prognosis of the elderly patients with bacterial infection

Washio, M., Ishibashi, N., Arai, Y., Kiyohara, C., Tanaka, K., Maeda, M., Fujishima, M. & Okayama, M., Jan 1 2000, In : International Medical Journal. 7, 2, p. 117-120 4 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

The relationship between aryl hydrocarbon hydroxylase activity and DNA adducts measured by 32P-postlabelling assay in lymphocytes of lung cancer patients

Zhang, J., Ichiba, M., Kiyohara, C., Nakanishi, Y., Takayama, K., Hara, N. & Tomokuni, K., Jan 1 2000, In : Biomarkers. 5, 2, p. 152-157 6 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Vγl+ γδ T cells play protective roles at an early phase of murine cytomegalovirus infection through production of interferon-γ

Ninomiya, T., Takimoto, H., Matsuzaki, G., Hamano, S., Yoshida, H., Yoshikai, Y., Kimura, G. & Nomoto, K., Jan 1 2000, In : Immunology. 99, 2, p. 187-194 8 p.

Research output: Contribution to journalArticle

53 Citations (Scopus)
1999

A new aspect of arsenic, an old poison

Hirata, M., Sep 1999, In : Fukuoka igaku zasshi = Hukuoka acta medica. 90, 9, p. 347-352 6 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of β-catenin

Kitagawa, M., Hatakeyama, S., Shirane, M., Matsumoto, M., Ishida, N., Hattori, K., Nakamichi, I., Kikuchi, A., Nakayama, K. I. & Nakayama, K., May 4 1999, In : EMBO Journal. 18, 9, p. 2401-2410 10 p.

Research output: Contribution to journalArticle

445 Citations (Scopus)

Antagonistic effects of an alternative splice variant of human IL-4, IL- 4δ2, on IL-4 activities in human monocytes and B cells

Arinobu, Y., Atamas, S. P., Otsuka, T., Niiro, H., Yamaoka, K., Mitsuyasu, H., Niho, Y., Hamasaki, N., White, B. & Izuhara, K., Feb 1 1999, In : Cellular Immunology. 191, 2, p. 161-167 7 p.

Research output: Contribution to journalArticle

66 Citations (Scopus)

Antisense inhibition of angiotensinogen attenuates vasopressin release in the paraventricular hypothalamic nucleus of spontaneously hypertensive rats

Kagiyama, S., Tsuchihashi, T., Abe, I., Matsumura, K. & Fujishima, M., May 22 1999, In : Brain Research. 829, 1-2, p. 120-124 5 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Association of the interferon-γ receptor variant (Val14Met) with systemic lupus erythematosus

Tanaka, Y., Nakashima, H., Hisano, C., Kohsaka, T., Nemoto, Y., Niiro, H., Otsuka, T., Otsuka, T., Imamura, T. & Niho, Y., Mar 18 1999, In : Immunogenetics. 49, 4, p. 266-271 6 p.

Research output: Contribution to journalArticle

53 Citations (Scopus)

Ca2+ sensitization and potentiation of the maximum level of myofibrillar ATPase activity caused by mutations of troponin T found in familial hypertrophic cardiomyopathy

Yanaga, F., Morimoto, S. & Ohtsuki, I., Mar 26 1999, In : Journal of Biological Chemistry. 274, 13, p. 8806-8812 7 p.

Research output: Contribution to journalArticle

90 Citations (Scopus)

Central adrenomedullin augments the baroreceptor reflex in conscious rabbits

Matsumura, K., Abe, I., Tsuchihashi, T. & Fujishima, M., Apr 1999, In : Hypertension. 33, 4, p. 992-997 6 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Differential effects of interleukin-4 and interleukin-10 on nitric oxide production by murine macrophages

Nemoto, Y., Otsuka, T., Niiro, H., Izuhara, K., Yamaoka, K., Nakashima, H. & Niho, Y., Dec 1 1999, In : Inflammation Research. 48, 12, p. 643-650 8 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Down-regulation of p27(Kip1) by two mechanisms, ubiquitin-mediated degradation and proteolytic processing

Shirane, M., Harumiya, Y., Ishida, N., Hirai, A., Miyamoto, C., Hatakeyama, S., Nakayama, K. I. & Kitagawa, M., May 14 1999, In : Journal of Biological Chemistry. 274, 20, p. 13886-18893 5008 p.

Research output: Contribution to journalArticle

210 Citations (Scopus)

Effects of chronic oral treatment with imidapril and TCV-116 on the responsiveness to angiotensin II in ventrolateral medulla of SHR

Tsuchihashi, T., Kagiyama, S., Matsumura, K., Abe, I. & Fujishima, M., Jul 21 1999, In : Journal of hypertension. 17, 7, p. 917-922 6 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Effects of interferon on circadian changes in blood pressure and heart rate variability in patients with chronic hepatitis

Fukuhara, M., Matsumura, K., Ohmori, S., Yanai, T., Tsubota, Y., Abe, I. & Fujishima, M., May 1 1999, In : American Journal of Hypertension. 12, 5, p. 519-523 5 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Effects of missense mutations Phe110Ile and Glu244Asp in human cardiac troponin T on force generation in skinned cardiac muscle fibers

Nakaura, H., Yanaga, F., Ohtsuki, I. & Morimoto, S., Jan 1 1999, In : Journal of biochemistry. 126, 3, p. 457-460 4 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

Expression of p53 and glutathione S-transferase-π relates to clinical drug resistance in non-small cell lung cancer

Nakanishi, Y., Kawasaki, M., Bai, F., Takayama, K., Pei, X. H., Takano, K., Inoue, K., Osaki, S. I., Hara, N. & Kiyohara, C., Nov 1999, In : Oncology. 57, 4, p. 318-323 6 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

Functional changes in troponin T by a splice donor site mutation that causes hypertrophic cardiomyopathy

Nakaura, H., Morimoto, S., Yanaga, F., Nakata, M., Nishi, H., Imaizumi, T. & Ohtsuki, I., Sep 11 1999, In : American Journal of Physiology - Cell Physiology. 277, 2 46-2, p. C225-C232

Research output: Contribution to journalArticle

42 Citations (Scopus)

Functional consequences of a carboxyl terminal missense mutation Arg278Cys in human cardiac troponin T

Morimoto, S., Nakaura, H., Yanaga, F. & Ohtsuki, I., Jul 22 1999, In : Biochemical and Biophysical Research Communications. 261, 1, p. 79-82 4 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

Hepatitis G virus infection in a high-risk subgroup of hospitalized dental patients

Takata, Y., Tateishi, A., Kurokawa, H., Fujikawa, M., Matsumura, K., Wakisaka, M., Fukuda, J. & Kajiyama, M., Jan 1 1999, In : Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics. 87, 4, p. 442-445 4 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Inverse association between coffee drinking and serum uric acid concentrations in middle-aged Japanese males

Kiyohara, C., Kono, S., Honjo, S., Todoroki, I., Sakurai, Y., Nishiwaki, M., Hamada, H., Nishikawa, H., Koga, H., Ogawa, S. & Nakagawa, K., Sep 2 1999, In : British Journal of Nutrition. 82, 2, p. 125-130 6 p.

Research output: Contribution to journalArticle

67 Citations (Scopus)

Obesity, weight gain and risk of colon adenomas in Japanese men

Kono, S., Handa, K., Hayabuchi, H., Kiyohara, C., Inoue, H., Marugame, T., Shinomiya, S., Hamada, H., Onuma, K. & Koga, H., Aug 1999, In : Japanese Journal of Cancer Research. 90, 8, p. 805-811 7 p.

Research output: Contribution to journalArticle

97 Citations (Scopus)

Polymorphisms within the interleukin-10 receptor cDNA gene (IL10R) in Japanese patients with systemic lupus erythematosus

Nakashima, H., Akahoshi, M., Tanaka, Y., Yamaoka, K., Ogami, E., Nagano, S., Arinobu, Y., Niiro, H., Otsuka, T. & Niho, Y., Nov 1999, In : Rheumatology. 38, 11, p. 1142-1144 3 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Protective effects of hochu-ekki-to, a Chinese traditional herbal medicine against murine cytomegalovirus infection

Hossain, M. S., Takimoto, H., Hamano, S., Yoshida, H., Ninomiya, T., Minamishima, Y., Kimura, G. & Nomoto, K., Apr 1 1999, In : Immunopharmacology. 41, 3, p. 169-181 13 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Relationship between aromatic-DNA adduct levels and inducibility of the drug metabolizing enzyme aryl hydrocarbon hydroxylase in lymphocytes

Kiyohara, C., Ichiba, M., Zhang, J., Nakanishi, Y., Takayama, K., Hara, N. & Hirohata, T., Dec 1 1999, In : Medical Science Research. 27, 10, p. 651-655 5 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Role of AT1 receptors in area postrema on baroreceptor reflex in spontaneously hypertensive rats

Matsumura, K., Averill, D. B. & Ferrario, C. M., Dec 11 1999, In : Brain Research. 850, 1-2, p. 166-172 7 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Selective DNA-binding activity of interleukin-10-stimulated STAT molecules in human monocytes

Yamaoka, K., Otsuka, T., Niiro, H., Nakashima, H., Tanaka, Y., Nagano, S., Ogami, E., Niho, Y., Hamasaki, N. & Izuhara, K., Jul 27 1999, In : Journal of Interferon and Cytokine Research. 19, 6, p. 679-685 7 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Subtypes of metabotropic glutamate receptors in the nucleus of the solitary tract of rats

Matsumura, K., Tsuchihashi, T., Kagiyama, S., Abe, I. & Fujishima, M., Sep 25 1999, In : Brain Research. 842, 2, p. 461-468 8 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Th1/Th2 balance of peripheral T helper cells in systemic lupus erythematosus

Akahoshi, M., Nakashima, H., Tanaka, Y., Kohsaka, T., Nagano, S., Ohgami, E., Arinobu, Y., Yamaoka, K., Niiro, H., Shinozaki, M., Hirakata, H., Horiuchi, T., Otsuka, T. & Niho, Y., Aug 1 1999, In : Arthritis and rheumatism. 42, 8, p. 1644-1648 5 p.

Research output: Contribution to journalArticle

229 Citations (Scopus)

The combination of polymorphisms within interferon-γ receptor I and receptor 2 associated with the risk of systemic lupus erythematosus

Nakashima, H., Inoue, H., Akahoshi, M., Tanaka, Y., Yamaoka, K., Ogami, E., Nagano, S., Arinobu, Y., Niiro, H., Otsuka, T. & Niho, Y., Jun 18 1999, In : FEBS Letters. 453, 1-2, p. 187-190 4 p.

Research output: Contribution to journalArticle

53 Citations (Scopus)