Department of Medical Education

Research Output 1983 2020

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1994
33 Citations (Scopus)

Ceramide does not mediate the effect of tumour necrosis factor α on superoxide generation in human neutrophils

Takahashi, F. & Watson, S. P., Jan 1 1994, In : Biochemical Journal. 298, 3, p. 733-738 6 p.

Research output: Contribution to journalArticle

Ceramides
Superoxides
Neutrophils
Tumor Necrosis Factor-alpha
Sphingomyelin Phosphodiesterase
2 Citations (Scopus)

Cerebellar Vermis Bleeding in a Patient with Hemophilia A: A Case Report

Kitazono, T., Okada, Y., Sadoshima, S., Utsunomiya, H. & Fujishima, M., Apr 1994, In : Angiology. 45, 4, p. 321-324 4 p.

Research output: Contribution to journalArticle

Hemophilia A
Craniocerebral Trauma
Neurologic Gait Disorders
Hemorrhage
Factor VIII
3 Citations (Scopus)

Dose-dependent testicular toxicity of propylene oxide in rats induced by repeated intraperitoneal injections

Omura, M., Tanaka, A., Mori, K., Hirata, M., Zao, M. & Inoue, N., Jan 1 1994, In : Fukuoka Acta Medica. 85, 7, p. 204-210 7 p.

Research output: Contribution to journalArticle

Intraperitoneal Injections
Sperm Count
Leydig Cells
Epididymis
Testosterone

Editorial comment

Kitazono, T., Jan 1 1994, In : Stroke. 25, 7, 1 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
Aryl Hydrocarbon Hydroxylases
Benzo(a)pyrene
Polychlorinated Biphenyls
Metabolites
Ascorbic Acid
8 Citations (Scopus)

Expression of the c‐kit ligand and interleukin 6 genes in mouse bone marrow stromal cell lines

Otsuka, T., Ogo, T., Nakano, T., Niiro, H., Kuga, S., Satoh, H., Furukawa, Y., Niho, Y. & Zipori, D., 1994, In : STEM CELLS. 12, 4, p. 409-415 7 p.

Research output: Contribution to journalArticle

Mesenchymal Stromal Cells
Interleukin-6
Ligands
Cell Line
Stromal Cells
15 Citations (Scopus)

Modulation of circadian rhythm of blood pressure by cortisol in patients with hypopituitarism

Matsumura, K., Abe, I., Fukuhara, M., Fujii, K., Ohya, Y., Okamura, K. & Fujishima, M., Jan 1 1994, In : Clinical and Experimental Hypertension. 16, 1, p. 55-66 12 p.

Research output: Contribution to journalArticle

Hypopituitarism
Circadian Rhythm
Hydrocortisone
Blood Pressure
Prednisolone
21 Citations (Scopus)

Naloxone augments sympathetic outflow induced by centrally administered endothelin in conscious rabbits

Matsumura, K., Abe, I., Fukuhara, M., Tominaga, M., Tsuchihashi, T., Kobayashi, K. & Fujishima, M., Jan 1 1994, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 266, 4 35-4, p. R1403-R1410

Research output: Contribution to journalArticle

Endothelins
Naloxone
Endothelin-1
Baroreflex
Rabbits

Naloxone augments sympathetic outflow induced by centrally administered endothelin in conscious rabbits

Matsumura, K., Abe, I., Fukuhara, M., Tominaga, M., Tsuchihashi, T., Kobayashi, K. & Fujishima, M., 1994, In : AM.J.PHYSIOL.. 266, 4 part 2

Research output: Contribution to journalArticle

naloxone
endothelins
Endothelins
Naloxone
rabbits
16 Citations (Scopus)

Pulmonary toxicity of indium arsenide and arsenic selenide following repeated intratracheal instillations to the lungs of hamsters

Tanaka, A., Hisanaga, A., Hirata, M., Omura, M., Inoue, N. & Ishinishi, N., May 1994, In : Applied Organometallic Chemistry. 8, 3, p. 265-271 7 p.

Research output: Contribution to journalArticle

Arsenic
Toxicity
Tumors
indium arsenide
Buffers
46 Citations (Scopus)
Diphosphates
Portal Vein
Nucleotides
Adenosine Triphosphate
Rabbits
31 Citations (Scopus)

Sequence heterogeneity of HTLV‐I proviral DNA in the central nervous system of patients with HTLV‐I–associated myelopathy

Kira, J. ., Koyanagi, Y., Yamada, T., Itoyama, Y., Tateishi, J., Akizuki, S. ., Kishikawa, M., Baba, E., Nakamura, M., Suzuki, J., Nakamura, T., Nakamura, N., Yamamoto, N. & Goto, I., Aug 1994, In : Annals of Neurology. 36, 2, p. 149-156 8 p.

Research output: Contribution to journalArticle

Tropical Spastic Paraparesis
Spinal Cord Diseases
Central Nervous System
Viruses
DNA
1993
11 Citations (Scopus)

A target K+ channel for the LP-805-induced hyperpolarization in smooth muscle cells of the rabbit portal vein

Kamouchi, M., Kajioka, S., Sakai, T., Kitamura, K. & Kuriyama, H., Mar 1993, In : Naunyn-Schmiedeberg's Archives of Pharmacology. 347, 3, p. 329-335 7 p.

Research output: Contribution to journalArticle

Portal Vein
Smooth Muscle Myocytes
Rabbits
Large-Conductance Calcium-Activated Potassium Channels
Charybdotoxin
4 Citations (Scopus)

CIRCADIAN VARIATIONS OF BLOOD PRESSURE AND PULSE RATE IN ESSENTIAL HYPERTENSIVES WITH DIABETES MELLITUS

Matsumura, K., Abe, I., Tsuchihashi, T., Kobayashi, K. & Fujishima, M., Mar 1993, In : Clinical and Experimental Pharmacology and Physiology. 20, 3, p. 155-160 6 p.

Research output: Contribution to journalArticle

Diabetes Mellitus
Heart Rate
Blood Pressure
Orthostatic Hypotension
Circadian Rhythm
5 Citations (Scopus)

Invasive Development of Right Atrial Myxoma— A Case Report

Nakayama, M., Matsumura, K., Abe, I., Kaku, R., Kobayashi, K., Fujishima, M., Aso, H., Tokunaga, K. & Ishii, Y., Sep 1993, In : Angiology. 44, 9, p. 739-744 6 p.

Research output: Contribution to journalArticle

Myxoma
Heart Atria
Brachiocephalic Veins
Superior Vena Cava
Thrombosis
2 Citations (Scopus)

In vivo effect of 7,8-benzoflavone on aryl hydrocarbon hydroxylase activity of mouse liver microsomes

Chikako, K. & Tomio, H., Feb 1993, In : Toxicology Letters. 66, 2, p. 199-207 9 p.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Hydroxylases
Methylcholanthrene
Liver Microsomes
Liver
Dichlorodiphenyldichloroethane
16 Citations (Scopus)

K channel openers activate different K channels in vascular smooth muscle cells

Kitamura, K. & Kamouchi, M., Aug 1 1993, In : Cardiovascular Drugs and Therapy. 7, 3 Supplement, p. 539-546 8 p.

Research output: Contribution to journalArticle

Portal Vein
Vascular Smooth Muscle
Smooth Muscle Myocytes
Rabbits
Glyburide
47 Citations (Scopus)

Multiple neutralizing B-cell epitopes of human T-cell leukemia virus type 1 (HTLV-1) identified by human monoclonal antibodies: A basis for the design of an HTLV-1 peptide vaccine

Baba, E., Nakamura, M., Tanaka, Y., Kuroki, M., Itoyama, Y., Nakano, S. & Niho, Y., Jan 1 1993, In : Journal of Immunology. 151, 2, p. 1013-1024 12 p.

Research output: Contribution to journalArticle

Deltaretrovirus
B-Lymphocyte Epitopes
Subunit Vaccines
Monoclonal Antibodies
Peptides
2 Citations (Scopus)

Synergism between muramyl dipeptide and lipopolysaccharide in the inhibition of glycosaminoglycan synthesis in cultured rat costal chondrocytes

Ikebe, T., Hirata, M., Yanaga, F. & Koga, T., Jan 1 1993, In : Annals of the Rheumatic Diseases. 52, 1, p. 32-36 5 p.

Research output: Contribution to journalArticle

Acetylmuramyl-Alanyl-Isoglutamine
Chondrocytes
Glycosaminoglycans
Lipopolysaccharides
Rats
3 Citations (Scopus)

The acute toxicity of allyl chloride by subcutaneous injection in mice.

Omura, M., Itonaga, Y., Komatsu, H., Mangen, Z., Hirata, M., Tanaka, A. & Inoue, N., Oct 1993, In : Fukuoka igaku zasshi = Hukuoka acta medica. 84, 10, p. 427-432 6 p.

Research output: Contribution to journalArticle

Leydig Cells
Subcutaneous Injections
Necrosis
Kidney Tubules
Inbred ICR Mouse
6 Citations (Scopus)

Transfection of interferon-γ gene in a mouse bone marrow stromal preadipocyte cell line causes apoptotic cell death

Nakano, T., Otsuka, T., Ogo, T., Niiro, H., Kuga, S., Zipori, D., Furukawa, Y. & Niho, Y., Dec 1 1993, In : Experimental Hematology. 21, 11, p. 1498-1503 6 p.

Research output: Contribution to journalArticle

Mesenchymal Stromal Cells
Interferons
Transfection
Cell Death
Cell Line
1992
7 Citations (Scopus)

Activation of cultured bovine aortic endothelial cells by extracellular pyrimidine triphosphate

Kitazono, T., Koichiro, T. & Shigeki, M., Jan 1 1992, In : International Journal of Biochemistry. 24, 8, p. 1323-1327 5 p.

Research output: Contribution to journalArticle

Endothelial cells
Endothelial Cells
Uridine Triphosphate
Adenosine Triphosphate
Chemical activation

Central effect of μ and δ opioids on neurohormonal and baroreflex regulation in conscious rabbits

Matsumura, K., Abe, I., Tsuchihashi, T., Tominaga, M., Kobayashi, K. & Fujishima, M., Jan 1 1992, In : Therapeutic Research. 13, 1, p. 212-217 6 p.

Research output: Contribution to journalArticle

Baroreflex
Opioid Analgesics
Rabbits
1 Citation (Scopus)

Comparison of suppression of mutagenicity of benzo(a)pyrene among methylsulfonyl polychlorinated biphenyl isomers

Kiyohara, C., Omura, M., Hirohata, T. & Masuda, Y., Jun 1 1992, In : Bulletin of Environmental Contamination and Toxicology. 48, 6, p. 877-883 7 p.

Research output: Contribution to journalArticle

mutagenicity
Pyrene
Polychlorinated biphenyls
pyrene
Isomers
16 Citations (Scopus)

Differential modulation by μ- and θ-opioids on baroreceptor reflex in conscious rabbits

Matsumura, K., Abe, I., Tominaga, M., Tsuchihashi, T., Kobayashi, K. & Fujishima, M., Jun 1992, In : Hypertension. 19, 6, p. 648-652 5 p.

Research output: Contribution to journalArticle

Baroreflex
Opioid Analgesics
Enkephalins
Rabbits
Naloxone
37 Citations (Scopus)

Epstein-Barr virus BCRF1 gene product (viral interleukin 10) inhibits superoxide anion production by human monocytes

Niiro, H., Otsuka, T., Abe, M., Satoh, H., Ogo, T., Nakano, T., Furukawa, Y. & Niho, Y., Jan 1 1992, In : Lymphokine and Cytokine Research. 11, 5, p. 209-214 6 p.

Research output: Contribution to journalArticle

Viral Proteins
Human Herpesvirus 4
Superoxides
Interleukin-10
Monocytes

In vitro/in vivo effects of 7,8-benzoflavone on aryl hydrocarbon hydroxylase activity of mice.

Kiyohara, C. & Hirohata, T., Oct 1992, In : Veterinary and human toxicology. 34, 5, p. 413-416 4 p.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Hydroxylases
unspecific monooxygenase
tetrachlorodibenzo-p-dioxin
Methylcholanthrene
mice
38 Citations (Scopus)

Signal transduction by tumor necrosis factor α is mediated through a guanine nucleotide-binding protein in osteoblast-like cell line, MC3T3-E1

Yanaga, F., Abe, M., Koga, T. & Hirata, M., Jan 1 1992, In : Journal of Biological Chemistry. 267, 8, p. 5114-5121 8 p.

Research output: Contribution to journalArticle

Signal transduction
Guanine Nucleotides
Osteoblasts
Signal Transduction
Carrier Proteins
54 Citations (Scopus)

Tumor necrosis factor α stimulates sphingomyelinase through the 55 kDa receptor in HL-60 cells

Yanaga, F. & Watson, S. P., Dec 21 1992, In : FEBS Letters. 314, 3, p. 297-300 4 p.

Research output: Contribution to journalArticle

Sphingomyelin Phosphodiesterase
HL-60 Cells
Sphingomyelins
Hydrolysis
Tumor Necrosis Factor-alpha
1991
4 Citations (Scopus)

Ambulatory blood pressure monitoring in elderly hypertensives treated with the new calcium antagonist, nilvadipine

Tsuchihashi, T., Tsukashima, A., Matsumura, K., Abe, I., Tominaga, M., Nakao, Y., Kobayashi, K. & Fujishima, M., Sep 1 1991, In : European Journal of Clinical Pharmacology. 41, 3, p. 255-257 3 p.

Research output: Contribution to journalArticle

nilvadipine
Ambulatory Blood Pressure Monitoring
Calcium
Blood Pressure
Heart Rate
5 Citations (Scopus)
4-Nitroquinoline-1-oxide
Xeroderma Pigmentosum
Cell Line
Survival
Homozygote
1 Citation (Scopus)

Cellular and subcellular clues to hypertension: Assessment from calcium mobilization data

Kamouchi, M., Akata, T., Xiong, Z., Inoue, R., Kitamura, K. & Kuriyama, H., Dec 1 1991, In : Journal of Vascular Medicine and Biology. 3, 4, p. 205-218 14 p.

Research output: Contribution to journalArticle

Hypertension
Calcium
49 Citations (Scopus)

Central effect of endothelin on neurohormonal responses in conscious rabbits

Matsumura, K., Abe, I., Tsuchihashi, T., Tominaga, M., Kobayashi, K. & Fujishima, M., Jun 1991, In : Hypertension. 17, 6 SUPPL. 2, p. 1192-1196 5 p.

Research output: Contribution to journalArticle

Endothelins
Endothelin-1
Rabbits
Kidney
Pentolinium Tartrate
30 Citations (Scopus)

Cromakalim dilates rat cerebral arteries in vitro

Nagao, T., Sadoshima, S., Kamouchi, M. & Fujishima, M., Feb 1991, In : Stroke. 22, 2, p. 221-224 4 p.

Research output: Contribution to journalArticle

Cromakalim
Cerebral Arteries
Arteries
Perfusion
Pressure
1 Citation (Scopus)

Disseminated intravascular coagulation in a patient with progressive systemic sclerosis associated with necrotizing angiitis and generalized lymphadenopathy

Kamouchi, M., Yoshinari, M., Goto, H., Ishitsuka, T., Murai, K., Tashiroh, K. & Fujishima, M., Jan 1 1991, In : Acta Haematologica. 86, 4, p. 203-205 3 p.

Research output: Contribution to journalArticle

Diffuse Scleroderma
Disseminated Intravascular Coagulation
Vasculitis
Lymphadenopathy
3 Citations (Scopus)

Distribution of sensitivity to 4-nitroquinoline 1-oxide among Japanese lymphoblastoid cell lines

Kiyohara, C., Hirohata, T., Kuratsune, M. & Nagayama, J., Jan 1 1991, In : Bulletin of Environmental Contamination and Toxicology. 46, 1, p. 62-68 7 p.

Research output: Contribution to journalArticle

Fluoresceins
4-Nitroquinoline-1-oxide
Fluorescein
Cells

Electrical properties of the voltage-dependent calcium channels in smooth muscle cells

Kitamura, K., Xiong, Z. L. & Kamouchi, M., May 1991, In : Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme. 36, 6, p. 869-879 11 p.

Research output: Contribution to journalArticle

Electric Conductivity
Endothelins
Second Messenger Systems
Calcium Channels
Muscle Contraction
37 Citations (Scopus)

Evidence for coupling of bradykinin receptors to a guanine-nucleotide binding protein to stimulate arachidonate liberation in the osteoblast-like cell line, MC3T3-E1

Fumi, Y., Masato, H. & Toshitaka, K., Sep 3 1991, In : BBA - Molecular Cell Research. 1094, 2, p. 139-146 8 p.

Research output: Contribution to journalArticle

Bradykinin Receptors
Guanine Nucleotides
Bradykinin
Osteoblasts
Radioactivity

Interrelationship of cellular fluorescein formation ability, an indication of cell viability, with environmental factors and with aryl hydrocarbon hydroxylase activity

Kiyohara, C., Hirohata, T., Kuratsune, M. & Nagayama, J., 1991, In : Chemosphere. 22, 8, p. 739-746 8 p.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Hydroxylases
Fluorescein
Cell Survival
viability
environmental factor
5 Citations (Scopus)
Aryl Hydrocarbon Hydroxylases
Microsomes
Ascorbic Acid
Liver
Aromatic Hydrocarbons
7 Citations (Scopus)
Bradycardia
Portal Vein
Smooth Muscle Myocytes
Rabbits
Glyburide
3 Citations (Scopus)

Severe Hypertension with Segmental Renal Infarction Following Surgical Removal of a Retroperitoneal Malignant Hemangiopericytoma: A Case Report

Matsumura, K., Muratani, H., Kinjou, K., Kimura, Y., Eto, T., Fukiyama, K. & Kusaba, A., Apr 1991, In : Angiology. 42, 4, p. 331-336 6 p.

Research output: Contribution to journalArticle

Infarction
Renin-Angiotensin System
Hypertension
Kidney
Angiotensins
4 Citations (Scopus)

Synthetic inositol 1,3,4,5-tetrakisphosphate analogues

Hirata, M., Kimura, Y., Ishimatsu, T., Takahashi, F., Shuto, T., Sasaguri, T., Koga, T., Watanabe, Y. & Ozaki, S., Jan 1 1991, In : Biochemical Journal. 276, 2, p. 333-336 4 p.

Research output: Contribution to journalArticle

Phosphoric Monoester Hydrolases
Inositol 1,4,5-Trisphosphate
inositol-1,3,4,5-tetrakisphosphate
Erythrocyte Membrane
Hydrolysis
1990
4 Citations (Scopus)

Aryl hydrocarbon hydroxylase activity levels in the hepatic microsomal fraction from MC- or TCDD-treated mice: a comparison between aromatic hydrocarbon responsive and non-responsive strains

Kiyohara, C., Mohri, N., Hirohata, T., Haraguchi, K., Masuda, Y. & Nagayama, J., Jun 1990, In : Toxicology Letters. 52, 1, p. 73-80 8 p.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Hydroxylases
Aromatic Hydrocarbons
Liver
Methylcholanthrene
Polycyclic Aromatic Hydrocarbons
11 Citations (Scopus)

Baroreceptor reflex in elderly essential hypertensives: Effect of chronic inhibition of angiotensin converting enzyme

Muratani, H., Kimura, Y., Matsumura, K., Noda, Y., Eto, T. & Fukiyama, K., Jan 1 1990, In : Clinical and Experimental Hypertension. A12, 1, p. 97-110 14 p.

Research output: Contribution to journalArticle

Baroreflex
Peptidyl-Dipeptidase A
Angiotensin II
Enalapril
Blood Pressure
2 Citations (Scopus)

Catabolic effects of muramyl dipeptide on rabbit chondrocytes

Ikebe, T., Iribe, H., Hirata, M., Yanaga, F. & Koga, T., 1990, In : Arthritis and Rheumatism. 33, 12, p. 1801-1806 6 p.

Research output: Contribution to journalArticle

Acetylmuramyl-Alanyl-Isoglutamine
Proteoglycans
Chondrocytes
Glycosaminoglycans
Rabbits
4 Citations (Scopus)
Tumors
Toxicity
gallium oxide
gallium arsenide
gallium phosphide
2 Citations (Scopus)

Comparative toxicologic study of 2,3,4,7,8-pentachlorodibenzofuran in Ah responsive and nonresponsive strains of mice

Nagayama, J., Kiyohara, C., Handa, S. & Horie, A., 1990, In : Chemosphere. 20, 7-9, p. 1165-1172 8 p.

Research output: Contribution to journalArticle

comparative study
toxicity
Liver
genotype
Toxicity
6 Citations (Scopus)

Effects of 3-methylsulphonyl-4,5,3′,4′-tetrachlorobiphenyl and 7,8-benzoflavone on mouse liver aryl hydrocarbon hydroxylase activity in vitro

Kiyohara, C., Hirohata, T., Mohri, N. & Masuda, Y., 1990, In : Toxicology in Vitro. 4, 2, p. 103-107 5 p.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Hydroxylases
Liver
Atrial Natriuretic Factor
Methylcholanthrene
Aromatic Hydrocarbons
50 Citations (Scopus)

Effects of glutathione depletion on the acute nephrotoxic potential of arsenite and on arsenic metabolism in hamsters

Hirata, M., Tanaka, A., Hisanaga, A. & Ishinishi, N., Dec 1990, In : Toxicology and Applied Pharmacology. 106, 3, p. 469-481 13 p.

Research output: Contribution to journalArticle

Buthionine Sulfoximine
Arsenic
Metabolism
Cricetinae
Glutathione