Department of Medical Education

Research Output 1983 2019

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Article
1995
1 Citation (Scopus)

Effects of polychlorinated dibenzo-p-dioxin and dibenzofuran congeners in human lymphoblastoid cells on aryl hydrocarbon hydroxylase activity

Kiyohara, C., Hirohata, T. & Masuda, Y., Jan 1 1995, In : Chemosphere. 31, 7, p. 3673-3680 8 p.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Hydroxylases
dibenzofuran
dioxin
Hydrocarbons
hydrocarbon
88 Citations (Scopus)

Inhibition by interleukin-10 of inducible cyclooxygenase expression in lipopolysaccharide-stimulated monocytes: Its underlying mechanism in comparison with interleukin-4

Niiro, H., Otsuka, T., Tanabe, T., Hara, S., Kuga, S., Nemoto, Y., Tanaka, Y., Nakashima, H., Kitajima, S., Abe, M. & Niho, Y., Jan 1 1995, In : Blood. 85, 12, p. 3736-3745 10 p.

Research output: Contribution to journalArticle

Cyclooxygenase 2
Prostaglandin-Endoperoxide Synthases
Interleukin-4
Interleukin-10
Lipopolysaccharides
3 Citations (Scopus)

Inhibitory Effects of Interleukin (IL)-10 and Viral IL-10 (vIL-10) on the Functions of Monocytes/Macrophages

Nemoto, Y., Otsuka, T., Niiro, H., Kuga, S., Tanaka, Y., Nakashima, H. & Niho, Y., Jan 1 1995, In : Japanese Journal of Clinical Immunology. 18, 2, p. 152-159 8 p.

Research output: Contribution to journalArticle

Interleukin-10
Monocytes
Macrophages
Interferons
Nitric Oxide
86 Citations (Scopus)

Opposing actions of angiotensin-(1-7) and angiotensin II in the brain of transgenic hypertensive rats

Moriguchi, A., Tallant, E. A., Matsumura, K., Reilly, T. M., Walton, H., Ganten, D. & Ferrario, C. M., Jan 1 1995, In : Hypertension. 25, 6, p. 1260-1265 6 p.

Research output: Contribution to journalArticle

Transgenic Rats
Angiotensin II
Antibodies
Brain
Lisinopril
20 Citations (Scopus)

Phenylarsine oxide inhibits tyrosine phosphorylation of phospholipase Cγ2 in human platelets and phospholipase Cγ1 in NIH-3T3 fibroblasts

Takahashi, F., Asselin, J., Schieven, G. L. & Watson, S. P., Jul 17 1995, In : FEBS Letters. 368, 2, p. 377-380 4 p.

Research output: Contribution to journalArticle

Phosphorylation
Phospholipases
Fibroblasts
Platelets
Tyrosine
86 Citations (Scopus)

Polymorphisms of human Ah receptor gene are not involved in lung cancer

Kawajiri, K., Watanabe, J., Eguchi, H., Nakachi, K., Kiyohara, C. & Hayashi, S. I., Jun 1995, In : Pharmacogenetics. 5, 3, p. 151-158 8 p.

Research output: Contribution to journalArticle

Lung Neoplasms
Gene Pool
Cytochrome P-450 CYP1A1
Germ Cells
Codon
9 Citations (Scopus)

Short Communication Toxic Effects of Gallium Arsenide on Sperm in Rats by Repeated Intratracheal Instillations

Omura, M., Tanaka, A., Zhao, M., Hirata, M., Maxita, Y., Inoue, N. & Gotoh, K., Jan 1 1995, In : Journal of Occupational Health. 37, 3, 1 p.

Research output: Contribution to journalArticle

Poisons
Semiconductor lasers
Spermatozoa
Rats
Communication
123 Citations (Scopus)

Syk interacts with tyrosine-phosphorylated proteins in human platelets activated by collagen and cross-linking of the Fcγ-IIA receptor

Takahashi, F., Poole, A., Asselin, J., Blake, R., Schieven, G. L., Clark, E. A., Law, C. L. & Watson, S. P., Jan 1 1995, In : Biochemical Journal. 311, 2, p. 471-478 8 p.

Research output: Contribution to journalArticle

Fc Receptors
Platelets
Tyrosine
Collagen
Blood Platelets
7 Citations (Scopus)

Urinary Incontinence in Elderly Patients in the Chronic Stage of Stroke

Kamouchi, M., Yamashita, Y., Ibavashi, S., Takaba, H., Omae, T., Sadoshima, S. & Fujishima, M., Jan 1 1995, In : Nippon Ronen Igakkai zasshi. Japanese journal of geriatrics. 32, 11, p. 741-746 6 p.

Research output: Contribution to journalArticle

Urinary Incontinence
Activities of Daily Living
Stroke
Dementia
Putaminal Hemorrhage
1994
97 Citations (Scopus)

ATP-sensitive K+ channels mediate dilatation of cerebral arterioles during hypoxia

Taguchi, H., Heistad, D. D., Kitazono, T. & Faraci, F. M., May 1994, In : Circulation research. 74, 5, p. 1005-1008 4 p.

Research output: Contribution to journalArticle

Arterioles
Dilatation
Glyburide
Adenosine Triphosphate
Vasodilation
33 Citations (Scopus)

Ceramide does not mediate the effect of tumour necrosis factor α on superoxide generation in human neutrophils

Takahashi, F. & Watson, S. P., Jan 1 1994, In : Biochemical Journal. 298, 3, p. 733-738 6 p.

Research output: Contribution to journalArticle

Ceramides
Superoxides
Neutrophils
Tumor Necrosis Factor-alpha
Sphingomyelin Phosphodiesterase
2 Citations (Scopus)

Cerebellar Vermis Bleeding in a Patient with Hemophilia A: A Case Report

Kitazono, T., Okada, Y., Sadoshima, S., Utsunomiya, H. & Fujishima, M., Apr 1994, In : Angiology. 45, 4, p. 321-324 4 p.

Research output: Contribution to journalArticle

Hemophilia A
Craniocerebral Trauma
Neurologic Gait Disorders
Hemorrhage
Factor VIII
3 Citations (Scopus)

Dose-dependent testicular toxicity of propylene oxide in rats induced by repeated intraperitoneal injections

Omura, M., Tanaka, A., Mori, K., Hirata, M., Zao, M. & Inoue, N., Jan 1 1994, In : Fukuoka Acta Medica. 85, 7, p. 204-210 7 p.

Research output: Contribution to journalArticle

Intraperitoneal Injections
Sperm Count
Leydig Cells
Epididymis
Testosterone

Editorial comment

Kitazono, T., Jan 1 1994, In : Stroke. 25, 7, 1 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
Aryl Hydrocarbon Hydroxylases
Benzo(a)pyrene
Polychlorinated Biphenyls
Metabolites
Ascorbic Acid
8 Citations (Scopus)

Expression of the c‐kit ligand and interleukin 6 genes in mouse bone marrow stromal cell lines

Otsuka, T., Ogo, T., Nakano, T., Niiro, H., Kuga, S., Satoh, H., Furukawa, Y., Niho, Y. & Zipori, D., 1994, In : STEM CELLS. 12, 4, p. 409-415 7 p.

Research output: Contribution to journalArticle

Mesenchymal Stromal Cells
Interleukin-6
Ligands
Cell Line
Stromal Cells
72 Citations (Scopus)

IL-10 inhibits prostaglandin E2 production by lipopolysaccharide-stimulated monocytes

Niiro, H., Otsuka, T., Kuga, S., Nemoto, Y., Abe, M., Hara, N., Nakano, T., Ogo, T. & Niho, Y., Apr 1 1994, In : International Immunology. 6, 4, p. 661-664 4 p.

Research output: Contribution to journalArticle

Dinoprostone
Interleukin-10
Lipopolysaccharides
Monocytes
Interleukin-4
15 Citations (Scopus)

Modulation of circadian rhythm of blood pressure by cortisol in patients with hypopituitarism

Matsumura, K., Abe, I., Fukuhara, M., Fujii, K., Ohya, Y., Okamura, K. & Fujishima, M., Jan 1 1994, In : Clinical and Experimental Hypertension. 16, 1, p. 55-66 12 p.

Research output: Contribution to journalArticle

Hypopituitarism
Circadian Rhythm
Hydrocortisone
Blood Pressure
Prednisolone

Naloxone augments sympathetic outflow induced by centrally administered endothelin in conscious rabbits

Matsumura, K., Abe, I., Fukuhara, M., Tominaga, M., Tsuchihashi, T., Kobayashi, K. & Fujishima, M., 1994, In : AM.J.PHYSIOL.. 266, 4 part 2

Research output: Contribution to journalArticle

naloxone
endothelins
Endothelins
Naloxone
rabbits
21 Citations (Scopus)

Naloxone augments sympathetic outflow induced by centrally administered endothelin in conscious rabbits

Matsumura, K., Abe, I., Fukuhara, M., Tominaga, M., Tsuchihashi, T., Kobayashi, K. & Fujishima, M., Jan 1 1994, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 266, 4 35-4

Research output: Contribution to journalArticle

Endothelins
Naloxone
Endothelin-1
Baroreflex
Rabbits
16 Citations (Scopus)

Pulmonary toxicity of indium arsenide and arsenic selenide following repeated intratracheal instillations to the lungs of hamsters

Tanaka, A., Hisanaga, A., Hirata, M., Omura, M., Inoue, N. & Ishinishi, N., May 1994, In : Applied Organometallic Chemistry. 8, 3, p. 265-271 7 p.

Research output: Contribution to journalArticle

Arsenic
Toxicity
Tumors
indium arsenide
Buffers
46 Citations (Scopus)
Diphosphates
Portal Vein
Nucleotides
Adenosine Triphosphate
Rabbits
1993
11 Citations (Scopus)

A target K+ channel for the LP-805-induced hyperpolarization in smooth muscle cells of the rabbit portal vein

Kamouchi, M., Kajioka, S., Sakai, T., Kitamura, K. & Kuriyama, H., Mar 1993, In : Naunyn-Schmiedeberg's Archives of Pharmacology. 347, 3, p. 329-335 7 p.

Research output: Contribution to journalArticle

Portal Vein
Smooth Muscle Myocytes
Rabbits
Large-Conductance Calcium-Activated Potassium Channels
Charybdotoxin
4 Citations (Scopus)

CIRCADIAN VARIATIONS OF BLOOD PRESSURE AND PULSE RATE IN ESSENTIAL HYPERTENSIVES WITH DIABETES MELLITUS

Matsumura, K., Abe, I., Tsuchihashi, T., Kobayashi, K. & Fujishima, M., Jan 1 1993, In : Clinical and Experimental Pharmacology and Physiology. 20, 3, p. 155-160 6 p.

Research output: Contribution to journalArticle

Diabetes Mellitus
Heart Rate
Blood Pressure
Orthostatic Hypotension
Circadian Rhythm
5 Citations (Scopus)

Invasive Development of Right Atrial Myxoma— A Case Report

Nakayama, M., Matsumura, K., Abe, I., Kaku, R., Kobayashi, K., Fujishima, M., Aso, H., Tokunaga, K. & Ishii, Y., Jan 1 1993, In : Angiology. 44, 9, p. 739-744 6 p.

Research output: Contribution to journalArticle

Myxoma
Heart Atria
Brachiocephalic Veins
Superior Vena Cava
Thrombosis
2 Citations (Scopus)

In vivo effect of 7,8-benzoflavone on aryl hydrocarbon hydroxylase activity of mouse liver microsomes

Chikako, K. & Tomio, H., Feb 1993, In : Toxicology Letters. 66, 2, p. 199-207 9 p.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Hydroxylases
Methylcholanthrene
Liver Microsomes
Liver
Dichlorodiphenyldichloroethane
16 Citations (Scopus)

K channel openers activate different K channels in vascular smooth muscle cells

Kitamura, K. & Kamouchi, M., Aug 1 1993, In : Cardiovascular Drugs and Therapy. 7, 3 Supplement, p. 539-546 8 p.

Research output: Contribution to journalArticle

Portal Vein
Vascular Smooth Muscle
Smooth Muscle Myocytes
Rabbits
Glyburide
5 Citations (Scopus)

Lecture: Effects of Hypertension on Cerebral Blood Vessels

Heistad, D. D., Baumbach, G. L., Kitazono, T. & Faraci, F. M., Jan 1 1993, In : Hypertension Research. 16, 4, p. 225-231 7 p.

Research output: Contribution to journalArticle

Blood Vessels
Hypertension
Cerebrovascular Circulation
KATP Channels
Arterioles
121 Citations (Scopus)

Role of ATP-sensitive K+ channels in CGRP-induced dilatation of basilar artery in vivo

Kitazono, T., Heistad, D. D. & Faraci, F. M., Sep 22 1993, In : American Journal of Physiology - Heart and Circulatory Physiology. 265, 2 34-2

Research output: Contribution to journalArticle

Basilar Artery
Calcitonin Gene-Related Peptide
Dilatation
Adenosine Triphosphate
Vasodilation
2 Citations (Scopus)

Synergism between muramyl dipeptide and lipopolysaccharide in the inhibition of glycosaminoglycan synthesis in cultured rat costal chondrocytes

Ikebe, T., Hirata, M., Yanaga, F. & Koga, T., Jan 1 1993, In : Annals of the Rheumatic Diseases. 52, 1, p. 32-36 5 p.

Research output: Contribution to journalArticle

Acetylmuramyl-Alanyl-Isoglutamine
Chondrocytes
Glycosaminoglycans
Lipopolysaccharides
Rats
3 Citations (Scopus)

The acute toxicity of allyl chloride by subcutaneous injection in mice.

Omura, M., Itonaga, Y., Komatsu, H., Mangen, Z., Hirata, M., Tanaka, A. & Inoue, N., Jan 1 1993, In : Fukuoka igaku zasshi = Hukuoka acta medica. 84, 10, p. 427-432 6 p.

Research output: Contribution to journalArticle

Leydig Cells
Subcutaneous Injections
Necrosis
Kidney Tubules
Inbred ICR Mouse
6 Citations (Scopus)

Transfection of interferon-γ gene in a mouse bone marrow stromal preadipocyte cell line causes apoptotic cell death

Nakano, T., Otsuka, T., Ogo, T., Niiro, H., Kuga, S., Zipori, D., Furukawa, Y. & Niho, Y., Dec 1 1993, In : Experimental Hematology. 21, 11, p. 1498-1503 6 p.

Research output: Contribution to journalArticle

Mesenchymal Stromal Cells
Interferons
Transfection
Cell Death
Cell Line
1992
7 Citations (Scopus)

Activation of cultured bovine aortic endothelial cells by extracellular pyrimidine triphosphate

Kitazono, T., Koichiro, T. & Shigeki, M., Jan 1 1992, In : International Journal of Biochemistry. 24, 8, p. 1323-1327 5 p.

Research output: Contribution to journalArticle

Endothelial cells
Endothelial Cells
Uridine Triphosphate
Adenosine Triphosphate
Chemical activation

Central effect of μ and δ opioids on neurohormonal and baroreflex regulation in conscious rabbits

Matsumura, K., Abe, I., Tsuchihashi, T., Tominaga, M., Kobayashi, K. & Fujishima, M., Jan 1 1992, In : Therapeutic Research. 13, 1, p. 212-217 6 p.

Research output: Contribution to journalArticle

Baroreflex
Opioid Analgesics
Rabbits
1 Citation (Scopus)

Comparison of suppression of mutagenicity of benzo(a)pyrene among methylsulfonyl polychlorinated biphenyl isomers

Kiyohara, C., Omura, M., Hirohata, T. & Masuda, Y., Jun 1 1992, In : Bulletin of Environmental Contamination and Toxicology. 48, 6, p. 877-883 7 p.

Research output: Contribution to journalArticle

Benzoflavones
Mutagenicity Tests
Aryl Hydrocarbon Hydroxylases
Benzo(a)pyrene
mutagenicity
16 Citations (Scopus)

Differential modulation by μ- and θ-opioids on baroreceptor reflex in conscious rabbits

Matsumura, K., Abe, I., Tominaga, M., Tsuchihashi, T., Kobayashi, K. & Fujishima, M., Jan 1 1992, In : Hypertension. 19, 6, p. 648-652 5 p.

Research output: Contribution to journalArticle

Baroreflex
Opioid Analgesics
Enkephalins
Rabbits
Naloxone
37 Citations (Scopus)

Epstein-Barr virus BCRF1 gene product (viral interleukin 10) inhibits superoxide anion production by human monocytes

Niiro, H., Otsuka, T., Abe, M., Satoh, H., Ogo, T., Nakano, T., Furukawa, Y. & Niho, Y., Jan 1 1992, In : Lymphokine and Cytokine Research. 11, 5, p. 209-214 6 p.

Research output: Contribution to journalArticle

Viral Proteins
Human Herpesvirus 4
Superoxides
Interleukin-10
Monocytes

In vitro/in vivo effects of 7,8-benzoflavone on aryl hydrocarbon hydroxylase activity of mice.

Kiyohara, C. & Hirohata, T., Jan 1 1992, In : Veterinary and human toxicology. 34, 5, p. 413-416 4 p.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Hydroxylases
unspecific monooxygenase
tetrachlorodibenzo-p-dioxin
Methylcholanthrene
mice
38 Citations (Scopus)

Signal transduction by tumor necrosis factor α is mediated through a guanine nucleotide-binding protein in osteoblast-like cell line, MC3T3-E1

Yanaga, F., Abe, M., Koga, T. & Hirata, M., Jan 1 1992, In : Journal of Biological Chemistry. 267, 8, p. 5114-5121 8 p.

Research output: Contribution to journalArticle

Signal transduction
Guanine Nucleotides
Osteoblasts
Signal Transduction
Carrier Proteins
54 Citations (Scopus)

Tumor necrosis factor α stimulates sphingomyelinase through the 55 kDa receptor in HL-60 cells

Yanaga, F. & Watson, S. P., Dec 21 1992, In : FEBS Letters. 314, 3, p. 297-300 4 p.

Research output: Contribution to journalArticle

Sphingomyelin Phosphodiesterase
HL-60 Cells
Sphingomyelins
Hydrolysis
Tumor Necrosis Factor-alpha
1991
4 Citations (Scopus)

Ambulatory blood pressure monitoring in elderly hypertensives treated with the new calcium antagonist, nilvadipine

Tsuchihashi, T., Tsukashima, A., Matsumura, K., Abe, I., Tominaga, M., Nakao, Y., Kobayashi, K. & Fujishima, M., Sep 1 1991, In : European Journal of Clinical Pharmacology. 41, 3, p. 255-257 3 p.

Research output: Contribution to journalArticle

nilvadipine
Ambulatory Blood Pressure Monitoring
Calcium
Blood Pressure
Heart Rate
5 Citations (Scopus)
4-Nitroquinoline-1-oxide
Xeroderma Pigmentosum
Cell Line
Survival
Homozygote
1 Citation (Scopus)

Cellular and subcellular clues to hypertension: Assessment from calcium mobilization data

Kamouchi, M., Akata, T., Xiong, Z., Inoue, R., Kitamura, K. & Kuriyama, H., Dec 1 1991, In : Journal of Vascular Medicine and Biology. 3, 4, p. 205-218 14 p.

Research output: Contribution to journalArticle

Hypertension
Calcium
49 Citations (Scopus)

Central effect of endothelin on neurohormonal responses in conscious rabbits

Matsumura, K., Abe, I., Tsuchihashi, T., Tominaga, M., Kobayashi, K. & Fujishima, M., Jun 1991, In : Hypertension. 17, 6 SUPPL. 2, p. 1192-1196 5 p.

Research output: Contribution to journalArticle

Endothelins
Endothelin-1
Rabbits
Kidney
Pentolinium Tartrate
31 Citations (Scopus)

Cromakalim dilates rat cerebral arteries in vitro

Nagao, T., Sadoshima, S., Kamouchi, M. & Fujishima, M., Feb 1991, In : Stroke. 22, 2, p. 221-224 4 p.

Research output: Contribution to journalArticle

Cromakalim
Cerebral Arteries
Arteries
Perfusion
Pressure
1 Citation (Scopus)

Disseminated intravascular coagulation in a patient with progressive systemic sclerosis associated with necrotizing angiitis and generalized lymphadenopathy

Kamouchi, M., Yoshinari, M., Goto, H., Ishitsuka, T., Murai, K., Tashiroh, K. & Fujishima, M., Jan 1 1991, In : Acta Haematologica. 86, 4, p. 203-205 3 p.

Research output: Contribution to journalArticle

Diffuse Scleroderma
Disseminated Intravascular Coagulation
Vasculitis
Lymphadenopathy
3 Citations (Scopus)

Distribution of sensitivity to 4-nitroquinoline 1-oxide among Japanese lymphoblastoid cell lines

Kiyohara, C., Hirohata, T., Kuratsune, M. & Nagayama, J., Jan 1 1991, In : Bulletin of Environmental Contamination and Toxicology. 46, 1, p. 62-68 7 p.

Research output: Contribution to journalArticle

Fluoresceins
4-Nitroquinoline-1-oxide
Cultured Tumor Cells
Xeroderma Pigmentosum
Preschool Children

Electrical properties of the voltage-dependent calcium channels in smooth muscle cells

Kitamura, K., Xiong, Z. L. & Kamouchi, M., Jan 1 1991, In : Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme. 36, 6, p. 869-879 11 p.

Research output: Contribution to journalArticle

Electric Conductivity
Endothelins
Second Messenger Systems
Calcium Channels
Muscle Contraction
37 Citations (Scopus)

Evidence for coupling of bradykinin receptors to a guanine-nucleotide binding protein to stimulate arachidonate liberation in the osteoblast-like cell line, MC3T3-E1

Takahashi, F., Hirata, M. & Toshitaka, K., Sep 3 1991, In : BBA - Molecular Cell Research. 1094, 2, p. 139-146 8 p.

Research output: Contribution to journalArticle

Bradykinin Receptors
Guanine Nucleotides
Bradykinin
Osteoblasts
Radioactivity

Interrelationship of cellular fluorescein formation ability, an indication of cell viability, with environmental factors and with aryl hydrocarbon hydroxylase activity

Kiyohara, C., Hirohata, T., Kuratsune, M. & Nagayama, J., Jan 1 1991, In : Chemosphere. 22, 8, p. 739-746 8 p.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Hydroxylases
Fluorescein
Cell Survival
viability
environmental factor