Department of Medicinal Sciences

Research Output 1983 2020

2020

Scandium(III) Triflate Catalyzed Direct Synthesis of N-Unprotected Ketimines

Kondo, Y., Kadota, T., Hirazawa, Y., Morisaki, K., Morimoto, H. & Ohshima, T., Jan 3 2020, In : Organic Letters. 22, 1, p. 120-125 6 p.

Research output: Contribution to journalArticle

Scandium
scandium
nitrogen compounds
synthesis
glycine
2019
1 Citation (Scopus)

2-Oxo-histidine-containing dipeptides are functional oxidation products

Ihara, H., Kakihana, Y., Yamakage, A., Kai, K., Shibata, T., Nishida, M., Kenichi, Y. & Uchida, K., Jan 1 2019, In : Journal of Biological Chemistry. 294, 4, p. 1279-1289 11 p.

Research output: Contribution to journalArticle

Carnosine
Dipeptides
Histidine
Oxidation
Antioxidants

A Convenient Preparation Method for Benzophenone Imine Catalyzed by Tetrabutylammonium Fluoride

Kondo, Y., Morisaki, K., Hirazawa, Y., Morimoto, H. & Ohshima, T., Aug 16 2019, In : Organic Process Research and Development. 23, 8, p. 1718-1724 7 p.

Research output: Contribution to journalArticle

Imines
imines
fluorides
preparation
synthesis

A deletion in the Ctns gene causes renal tubular dysfunction and cystine accumulation in LEA/Tohm rats

Shimizu, Y., Yanobu-Takanashi, R., Nakano, K., Hamase, K., Shimizu, T. & Okamura, T., Feb 13 2019, In : Mammalian Genome. 30, 1-2, p. 23-33 11 p.

Research output: Contribution to journalArticle

Cystine
Kidney
Glucose
Cystinosis
Genes
1 Citation (Scopus)

Ammonium Salt-Accelerated Hydrazinolysis of Unactivated Amides: Mechanistic Investigation and Application to a Microwave Flow Process

Noshita, M., Shimizu, Y., Morimoto, H., Akai, S., Hamashima, Y., Ohneda, N., Odajima, H. & Ohshima, T., Apr 19 2019, In : Organic Process Research and Development. 23, 4, p. 588-594 7 p.

Research output: Contribution to journalArticle

hydrazine
Ammonium Compounds
Amides
amides
Salts

Development of novel functional molecules targeting DNA and RNA

Sasaki, S., Jan 1 2019, In : Chemical and Pharmaceutical Bulletin. 67, 6, p. 505-518 14 p.

Research output: Contribution to journalReview article

Open Access
Nucleosides
Oligonucleotides
Artificial Receptors
RNA
Molecules
4 Citations (Scopus)

Development of Turn-On Probes for Acids Triggered by Aromaticity Enhancement Using Tricyclic Amidine Derivatives

Matsumoto, S., Fuchi, Y., Usui, K., Hirai, G. & Karasawa, S., Jun 7 2019, In : Journal of Organic Chemistry. 84, 11, p. 6612-6622 11 p.

Research output: Contribution to journalArticle

Amidines
Fluorescence
Protonation
Quantum yield
Derivatives
1 Citation (Scopus)

D -Serine reflects kidney function and diseases

Hesaka, A., Sakai, S., Hamase, K., Ikeda, T., Matsui, R., Mita, M., Horio, M., Isaka, Y. & Kimura, T., Dec 1 2019, In : Scientific reports. 9, 1, 5104.

Research output: Contribution to journalArticle

Open Access
Kidney Diseases
Serine
Chronic Renal Insufficiency
Kidney
Amino Acids

Effects of Substituents on the Properties of Metal-Free MRI Contrast Agents

Shiraishi, R., Kaneko, T., Usui, K., Naganuma, T., Iizuka, N., Morishita, K., Kobayashi, S., Fuchi, Y., Matsuoka, Y., Hirai, G., Yamada, K. I. & Karasawa, S., Dec 10 2019, In : ACS Omega. 4, 24, p. 20715-20723 9 p.

Research output: Contribution to journalArticle

Open Access
Magnetic resonance
Contrast Media
Gadolinium
Metals
Imaging techniques
Open Access
DNA-Directed DNA Polymerase
DNA Polymerase I
Adenosine
Nucleotides
Derivatives

Electron Microscopic Detection of Single Membrane Proteins by a Specific Chemical Labeling

Tabata, S., Jevtic, M., Kurashige, N., Fuchida, H., Kido, M., Tani, K., Zenmyo, N., Uchinomiya, S., Harada, H., Itakura, M., Hamachi, I., Shigemoto, R. & Ojida, A., Dec 20 2019, In : iScience. 22, p. 256-268 13 p.

Research output: Contribution to journalArticle

Open Access
Labeling
Membrane Proteins
Electrons
Electron microscopy
Proteins

Enhancement of saccharothriolide production and discovery of a new metabolite, saccharothriolide C 2 , by combined-culture of Saccharothrix sp. and Tsukamurella pulmonis

Jiang, Y., Lu, S., Hirai, G., Kato, T., Onaka, H. & Kakeya, H., Apr 11 2019, In : Tetrahedron Letters. 60, 15, p. 1072-1074 3 p.

Research output: Contribution to journalArticle

Mycolic Acids
Metabolites
Bacteria

Identification of candidate molecular targets of the novel antineoplastic antimitotic NP-10

Yokoyama, T., Yukuhiro, M., Iwasaki, Y., Tanaka, C., Sankoda, K., Fujiwara, R., Shibuta, A., Higashi, T., Motoyama, K., Arima, H., Yoshida, K., Sugimoto, N., Morimoto, H., Kosako, H., Ohshima, T. & Fujita, M., Dec 1 2019, In : Scientific reports. 9, 1, 16825.

Research output: Contribution to journalArticle

Open Access
Antimitotic Agents
Antineoplastic Agents
polyoxyethylene(10)nonylphenyl ether
Karyopherins
HCT116 Cells
2 Citations (Scopus)

In Vivo Imaging of the Intra-and Extracellular Redox Status in Rat Stomach with Indomethacin-Induced Gastric Ulcers Using Overhauser-Enhanced Magnetic Resonance Imaging

Yasukawa, K., Shigemi, R., Kanbe, T., Mutsumoto, Y., Oda, F., Ichikawa, K., Yamada, K-I., Tun, X. & Utsumi, H., Jan 1 2019, In : Antioxidants and Redox Signaling. 30, 9, p. 1147-1161 15 p.

Research output: Contribution to journalArticle

Stomach Ulcer
Indomethacin
Oxidation-Reduction
Rats
Stomach

Kinetics and localisation of haemin-induced lipoprotein oxidation

Morales, N. P., Chunephisal, P., Janprasit, J., Ishida, Y., Luechapudiporn, R. & Yamada, K. I., Oct 3 2019, In : Free Radical Research. 53, 9-10, p. 968-978 11 p.

Research output: Contribution to journalArticle

Hemin
Lipoproteins
Oxidation
Kinetics
Paramagnetic resonance

Mechanistic insight into catalytic aerobic chemoselective α-oxidation of acylpyrazoles

Taninokuchi, S., Yazaki, R. & Ohshima, T., Jan 1 2019, In : Heterocycles. 99, 2, p. 906-918 13 p.

Research output: Contribution to journalArticle

Open Access
Catalysis
Lewis Acids
Oxidation
Hydroxy Acids
Isotopes

New applications of high-resolution analytical methods to study trace organic compounds in extraterrestrial materials

Naraoka, H., Hashiguchi, M., Sato, Y. & Hamase, K., Sep 2019, In : Life. 9, 3, 62.

Research output: Contribution to journalReview article

Open Access
Meteoroids
organic compounds
Organic compounds
analytical methods
organic compound
1 Citation (Scopus)

Non-invasive mapping of glutathione levels in mouse brains by in vivo electron paramagnetic resonance (EPR) imaging: Applied to a kindling mouse model

Emoto, M. C., Sato-Akaba, H., Matsuoka, Y., Yamada, K-I. & Fujii, H. G., Jan 18 2019, In : Neuroscience Letters. 690, p. 6-10 5 p.

Research output: Contribution to journalArticle

Electron Spin Resonance Spectroscopy
Glutathione
Brain
Brain Mapping
Pentylenetetrazole

Nuciferols A and B: Novel sesquineolignans from Cocos nucifera

Elsbaey, M., Jie, B., Tanaka, C., Kato, H., Tsukamoto, S., Usui, K., Hirai, G. & Miyamoto, T., Aug 15 2019, In : Tetrahedron Letters. 60, 33, 150948.

Research output: Contribution to journalArticle

Cocos
Scavenging
Neuroprotective Agents
Cell death
Skeleton
1 Citation (Scopus)

Optimized reaction pair of the Cyshis tag and Ni(II)-Nta probe for highly selective chemical labeling of membrane proteins

Zenmyo, N., Tokumaru, H., Uchinomiya, S., Fuchida, H., Tabata, S., Hamachi, I., Shigemoto, R. & Ojida, A., Jan 1 2019, In : Bulletin of the Chemical Society of Japan. 92, 5, p. 995-1000 6 p.

Research output: Contribution to journalArticle

Labeling
Membrane Proteins
Proteins
Cells
Molecular Probes

Radiation-induced redox alteration in the mouse brain

Nakamura, M., Yamasaki, T., Ueno, M., Shibata, S., Ozawa, Y., Kamada, T., Nakanishi, I., Yamada, K. I., Aoki, I. & Matsumoto, K. I., Nov 1 2019, In : Free Radical Biology and Medicine. 143, p. 412-421 10 p.

Research output: Contribution to journalArticle

Oxidation-Reduction
Brain
Carbon
Ion beams
Irradiation

Recent strategic advances for the activation of benzylic C–H bonds for the formation of C–C bonds

Yazaki, R. & Ohshima, T., Nov 7 2019, In : Tetrahedron Letters. 60, 45, 151225.

Research output: Contribution to journalReview article

Hydrocarbons
Anions
Chemical activation
Feedstocks
9 Citations (Scopus)

Selective and reversible modification of kinase cysteines with chlorofluoroacetamides

Shindo, N., Fuchida, H., Sato, M., Watari, K., Shibata, T., Kuwata, K., Miura, C., Okamoto, K., Hatsuyama, Y., Tokunaga, K., Sakamoto, S., Morimoto, S., Abe, Y., Shiroishi, M., Caaveiro, J. M. M., Ueda, T., Tamura, T., Matsunaga, N., Nakao, T., Koyanagi, S. & 5 others, Ohdo, S., Yamaguchi, Y., Hamachi, I., Ono, M. & Ojida, A., Jan 14 2019, In : Nature Chemical Biology.

Research output: Contribution to journalArticle

Quinazolines
Epidermal Growth Factor Receptor
Cysteine
Phosphotransferases
Hydrolysis

Serum d-serine accumulation after proximal renal tubular damage involves neutral amino acid transporter Asc-1

Suzuki, M., Gonda, Y., Yamada, M., Vandebroek, A. A., Mita, M., Hamase, K., Yasui, M. & Sasabe, J., Dec 1 2019, In : Scientific reports. 9, 1, 16705.

Research output: Contribution to journalArticle

Open Access
Neutral Amino Acid Transport Systems
Serine
Kidney
Serum
Cisplatin

Stereospecific Overman Rearrangement of Substituted Cyclic Vinyl Bromides: Access to Fully Substituted α-Amino Ketones

Velasco-Rubio, Á., Alexy, E. J., Yoritate, M., Wright, A. C. & Stoltz, B. M., Nov 15 2019, In : Organic Letters. 21, 22, p. 8962-8965 4 p.

Research output: Contribution to journalArticle

Enantioselectivity
Ketones
ketones
Amines
bromides

Study of the inducible cross-linking reaction to mRNA and the effect on the translation

Kikuta, K., Taniguchi, Y. & Sasaki, S., Jan 1 2019, In : Chemical and Pharmaceutical Bulletin. 67, 8, p. 877-883 7 p.

Research output: Contribution to journalArticle

Open Access
Cross Reactions
Derivatives
Messenger RNA
Oligoribonucleotides
Uracil
Acridines
Chemiluminescence
Choline
Hydrogen peroxide
Hydrogen Peroxide
Oligonucleotides
Pseudouridine
Derivatives
Uracil
Oligodeoxyribonucleotides

Synthesis of All Stereoisomers of Monomeric Spectomycin A1/A2 and Evaluation of Their Protein SUMOylation-Inhibitory Activity

Nomura, Y., Thuaud, F., Sekine, D., Ito, A., Maeda, S., Koshino, H., Hashizume, D., Muranaka, A., Cruchter, T., Uchiyama, M., Ichikawa, S., Matsuda, A., Yoshida, M., Hirai, G. & Sodeoka, M., Jun 21 2019, In : Chemistry - A European Journal. 25, 35, p. 8387-8392 6 p.

Research output: Contribution to journalArticle

Stereoisomerism
Isomers
Stereochemistry
Proteins
Optical rotation
1 Citation (Scopus)

Synthesis of All Stereoisomers of RK460 and Evaluation of Their Activity and Selectivity as Abscisic Acid Receptor Antagonists

Mikame, Y., Yoshida, K., Hashizume, D., Hirai, G., Nagasawa, K., Osada, H. & Sodeoka, M., Mar 7 2019, In : Chemistry - A European Journal. 25, 14, p. 3496-3500 5 p.

Research output: Contribution to journalArticle

Abscisic Acid
Stereochemistry
Stereoisomerism
Agrochemicals
Lead compounds
3 Citations (Scopus)

Synthesis of CH 2 -Linked α(1,6)-Disaccharide Analogues by α-Selective Radical Coupling C-Glycosylation

Kiya, N., Hidaka, Y., Usui, K. & Hirai, G., Mar 15 2019, In : Organic Letters. 21, 6, p. 1588-1592 5 p.

Research output: Contribution to journalArticle

Glycosylation
Glycoconjugates
Disaccharides
carbohydrates
linkages

Synthesis of the deuterated thymidine-d9 and deuterated oligonucleotides

Taniguchi, Y., Cao, X. & Sasaki, S., Sep 19 2019, In : Tetrahedron Letters. 60, 38, 151037.

Research output: Contribution to journalArticle

Oligonucleotides
Thymidine
Glycosylation
Sugars
DNA

Synthesis of γ-N-modified 8-oxo-2’-deoxyguanosine triphosphate and its characterization

Thavoncharoensub, N., Maruyama, K., Heh, C. H., Hoong Leong, K., Shi, H., Shigematsu, Y., Sasaki, S. & Taniguchi, Y., Aug 3 2019, In : Nucleosides, Nucleotides and Nucleic Acids. 38, 8, p. 578-589 12 p.

Research output: Contribution to journalArticle

DNA-Directed DNA Polymerase
Nucleotides
DNA Replication
Reactive Oxygen Species
Repair
Thioguanine
Polyamines
Ligands
Repair
DNA

Thionoesters as 1,2-Dipolarophiles for [4+2] Cycloaddition with Cyclobutanones

Matsumoto, Y., Tsuji, T., Nakatake, D., Yazaki, R. & Ohshima, T., Jul 1 2019, In : Asian Journal of Organic Chemistry. 8, 7, p. 1071-1074 4 p.

Research output: Contribution to journalArticle

Cycloaddition
Carbon Monoxide
Biological Products
Ketones
Carbon

Three-Dimensional High-Performance Liquid Chromatographic Determination of Asn, Ser, Ala, and Pro Enantiomers in the Plasma of Patients with Chronic Kidney Disease

Furusho, A., Koga, R., Akita, T., Mita, M., Kimura, T. & Hamase, K., Sep 17 2019, In : Analytical chemistry. 91, 18, p. 11569-11575 7 p.

Research output: Contribution to journalArticle

Enantiomers
Plasmas
Amino Acids
Liquids
Plasma (human)
2018
6 Citations (Scopus)

3-Mono-Substituted BINOL Phosphoric Acids as Effective Organocatalysts in Direct Enantioselective Friedel–Crafts-Type Alkylation of N-Unprotected α-Ketiminoester

Yonesaki, R., Kondo, Y., Akkad, W., Sawa, M., Morisaki, K., Morimoto, H. & Ohshima, T., Oct 12 2018, In : Chemistry - A European Journal. 24, 57, p. 15211-15214 4 p.

Research output: Contribution to journalArticle

Phosphoric Acids
Enantioselectivity
Alkylation
Phosphoric acid
Catalysts
26 Citations (Scopus)
Cyclopropanes
Cycloaddition
Catalysis
Iron
tetrahydrothiophene
1 Citation (Scopus)

Antioxidant nitroxides protect hepatic cells from oxidative stress-induced cell death

Shinto, S., Matsuoka, Y., Yamato, M. & Yamada, K. I., Mar 2018, In : Journal of Clinical Biochemistry and Nutrition. 62, 2, p. 132-138 7 p.

Research output: Contribution to journalArticle

Oxidative stress
Cell death
Hepatocytes
Oxidative Stress
Cell Death
1 Citation (Scopus)

Bioconjugation with Thiols by Benzylic Substitution

Watanabe, K. & Ohshima, T., Mar 15 2018, In : Chemistry - A European Journal. 24, 16, p. 3959-3964 6 p.

Research output: Contribution to journalArticle

Muramidase
Sulfhydryl Compounds
Substitution reactions
Enzymes
Kinetics
10 Citations (Scopus)

Catalytic Enantioselective Decarboxylative Mannich-Type Reaction of N-Unprotected Isatin-Derived Ketimines

Sawa, M., Miyazaki, S., Yonesaki, R., Morimoto, H. & Ohshima, T., Sep 7 2018, In : Organic Letters. 20, 17, p. 5393-5397 5 p.

Research output: Contribution to journalArticle

Isatin
synthesis
AG-041R
ketimine
Oligonucleotides
Nucleic Acids
Genes
DNA sequences
Nucleosides
10 Citations (Scopus)

Chemoselective Catalytic Dehydrogenative Cross-Coupling of 2-Acylimidazoles: Mechanistic Investigations and Synthetic Scope

Tanaka, T., Hashiguchi, K., Tanaka, T., Yazaki, R. & Ohshima, T., Sep 7 2018, In : ACS Catalysis. 8, 9, p. 8430-8440 11 p.

Research output: Contribution to journalArticle

phosphine
Carbon
Iron
Chemical activation
Alkanes
5 Citations (Scopus)
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Connexins
varespladib methyl
Astrocytes
Parkinson Disease
6 Citations (Scopus)

D-Amino acids in molecular evolution in space – Absolute asymmetric photolysis and synthesis of amino acids by circularly polarized light

Sugahara, H., Meinert, C., Nahon, L., Jones, N. C., Hoffmann, S. V., Hamase, K., Takano, Y. & Meierhenrich, U. J., Jul 1 2018, In : Biochimica et Biophysica Acta - Proteins and Proteomics. 1866, 7, p. 743-758 16 p.

Research output: Contribution to journalReview article

Molecular Evolution
Photolysis
Light polarization
Light
Amino Acids

Detection and inhibition of redox reaction and lipid derived radicals

Yamada, K-I., Jan 1 2018, In : Drug Delivery System. 33, 3, p. 197-203 7 p.

Research output: Contribution to journalArticle

Oxidation-Reduction
Lipids
Free Radicals
Animal Models
Carcinogenesis
8 Citations (Scopus)
Amino Acids
Fluids
Liquids
High Pressure Liquid Chromatography
L Forms
1 Citation (Scopus)
Carbonyl compounds
Rhodium
Catalysts
Proton transfer
Thalidomide
3 Citations (Scopus)
Plasma (human)
3-Hydroxybutyric Acid
High performance liquid chromatography
Lactic Acid
Enantiomers
2 Citations (Scopus)

Endogenous Membrane Receptor Labeling by Reactive Cytokines and Growth Factors to Chase Their Dynamics in Live Cells

Takaoka, Y., Uchinomiya, S., Kobayashi, D., Endo, M., Hayashi, T., Fukuyama, Y., Hayasaka, H., Miyasaka, M., Ueda, T., Shimada, I. & Hamachi, I., Jun 14 2018, In : Chem. 4, 6, p. 1451-1464 14 p.

Research output: Contribution to journalArticle

Labeling
Intercellular Signaling Peptides and Proteins
Cytokines
membrane
Membranes