Department of Medicinal Sciences

Research Output 1985 2019

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Review article
2019

Development of novel functional molecules targeting DNA and RNA

Sasaki, S., Jan 1 2019, In : Chemical and Pharmaceutical Bulletin. 67, 6, p. 505-518 14 p.

Research output: Contribution to journalReview article

Open Access
Nucleosides
Oligonucleotides
Artificial Receptors
RNA
Molecules

New applications of high-resolution analytical methods to study trace organic compounds in extraterrestrial materials

Naraoka, H., Hashiguchi, M., Sato, Y. & Hamase, K., Sep 2019, In : Life. 9, 3, 62.

Research output: Contribution to journalReview article

Open Access
Meteoroids
organic compounds
Organic compounds
analytical methods
organic compound

Recent strategic advances for the activation of benzylic C–H bonds for the formation of C–C bonds

Yazaki, R. & Ohshima, T., Nov 7 2019, In : Tetrahedron Letters. 60, 45, 151225.

Research output: Contribution to journalReview article

Hydrocarbons
Anions
Chemical activation
Feedstocks
2018
6 Citations (Scopus)

D-Amino acids in molecular evolution in space – Absolute asymmetric photolysis and synthesis of amino acids by circularly polarized light

Sugahara, H., Meinert, C., Nahon, L., Jones, N. C., Hoffmann, S. V., Hamase, K., Takano, Y. & Meierhenrich, U. J., Jul 1 2018, In : Biochimica et Biophysica Acta - Proteins and Proteomics. 1866, 7, p. 743-758 16 p.

Research output: Contribution to journalReview article

Molecular Evolution
Photolysis
Light polarization
Light
Amino Acids
2017
9 Citations (Scopus)

Fluorescence Sensing of Inorganic Phosphate and Pyrophosphate Using Small Molecular Sensors and Their Applications

Wongkongkatep, J., Ojida, A. & Hamachi, I., Apr 1 2017, In : Topics in Current Chemistry. 375, 2, 30.

Research output: Contribution to journalReview article

Fluorescence
Phosphates
Sensors
Chemical reactions
Quenching
10 Citations (Scopus)

Mouse D-amino-acid oxidase: Distribution and physiological substrates

Koga, R., Miyoshi, Y., Sakaue, H., Hamase, K. & Konno, R., Dec 4 2017, In : Frontiers in Molecular Biosciences. 4, DEC, 82.

Research output: Contribution to journalReview article

D-Amino-Acid Oxidase
Substrates
Serine
Amino Acids
Alanine
2016

Development of a functional contrast agent for targeting lipid-derived radicals

Yamada, K. I., Jan 1 2016, In : Yakugaku Zasshi. 136, 8, p. 1093-1100 8 p.

Research output: Contribution to journalReview article

Contrast Media
Lipids
Electrons
Oxidative Stress
Fluorescence

Development of fluorescence sensing mechanism for cell functional analysis

Ojida, A. & Takashima, I., Jan 1 2016, In : Yakugaku Zasshi. 136, 1, p. 3-7 5 p.

Research output: Contribution to journalReview article

Fluorescent Dyes
Fluorescence
Metals
Ions
Biological Phenomena
12 Citations (Scopus)
Zinc
Esters
Transesterification
Amines
Catalyst activity
10 Citations (Scopus)

Fluorescence probe for the convenient and sensitive detection of ascorbic acid

Matsuoka, Y., Yamato, M. & Yamada, K. I., Jan 2016, In : Journal of Clinical Biochemistry and Nutrition. 58, 1, p. 16-22 7 p.

Research output: Contribution to journalReview article

Ascorbic Acid
Fluorescence
Fluorescent Dyes
Oxidation-Reduction
Electrons
Amination
Carbonyl compounds
2014
Nucleophiles
Addition reactions
Alkenes
Oxygen
25 Citations (Scopus)

Peptide tag/probe pairs based on the coordination chemistry for protein labeling

Uchinomiya, S., Ojida, A. & Hamachi, I., Feb 17 2014, In : Inorganic chemistry. 53, 4, p. 1816-1823 8 p.

Research output: Contribution to journalReview article

Labeling
marking
peptides
chemistry
proteins
2013
194 Citations (Scopus)

Protein organic chemistry and applications for labeling and engineering in live-cell systems

Takaoka, Y., Ojida, A. & Hamachi, I., Apr 8 2013, In : Angewandte Chemie - International Edition. 52, 15, p. 4088-4106 19 p.

Research output: Contribution to journalReview article

Labeling
Proteins
Amino acids
Organic Chemistry
Amino Acids
2012
28 Citations (Scopus)

D-Amino acids in the brain and mutant rodents lacking D-amino-acid oxidase activity

Yamanaka, M., Miyoshi, Y., Ohide, H., Hamase, K. & Konno, R., Nov 1 2012, In : Amino Acids. 43, 5, p. 1811-1821 11 p.

Research output: Contribution to journalReview article

D-Amino-Acid Oxidase
Rodentia
Brain
Serine
Amino Acids
60 Citations (Scopus)

HPLC analysis of naturally occurring free d-amino acids in mammals

Miyoshi, Y., Koga, R., Oyama, T., Han, H., Ueno, K., Masuyama, K., Itoh, Y. & Hamase, K., Oct 1 2012, In : Journal of Pharmaceutical and Biomedical Analysis. 69, p. 42-49 8 p.

Research output: Contribution to journalReview article

Mammals
High Pressure Liquid Chromatography
Amino Acids
Metabolomics
Enantiomers
3 Citations (Scopus)

Intracellular logistics of BST-2/Tetherin

Fujita, H., Fujimoto, K., Tokunaga, K. & Tanaka, Y., Jun 2012, In : Current HIV Research. 10, 4, p. 321-326 6 p.

Research output: Contribution to journalReview article

Bone Marrow
Antigens
Glycosylphosphatidylinositols
Membrane Lipids
Endocytosis
2011
59 Citations (Scopus)

D-Amino acid metabolism in mammals: Biosynthesis, degradation and analytical aspects of the metabolic study

Ohide, H., Miyoshi, Y., Maruyama, R., Hamase, K. & Konno, R., Nov 1 2011, In : Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 879, 29, p. 3162-3168 7 p.

Research output: Contribution to journalReview article

Mammals
Biosynthesis
Metabolism
Aspartic Acid
Amino Acids
19 Citations (Scopus)

The oligodeoxynucleotide probes for the site-specific modification of RNA

Sasaki, S., Onizuka, K. & Taniguchi, Y., Dec 1 2011, In : Chemical Society Reviews. 40, 12, p. 5698-9706 4009 p.

Research output: Contribution to journalReview article

Oligodeoxyribonucleotides
RNA
Chemical modification
Relocation
Oligonucleotides
2010
20 Citations (Scopus)

Mutant mice and rats lacking D-amino acid oxidase

Konno, R., Hamase, K., Maruyama, R. & Zaitsu, K., Jun 2010, In : Chemistry and Biodiversity. 7, 6, p. 1450-1458 9 p.

Research output: Contribution to journalReview article

D-Amino-Acid Oxidase
Amino acids
Rats
Amino Acids
Serine
2009
1 Citation (Scopus)

Analysis of in vivo redox status with magnetic resonance technique

Ichikawa, K., Yamada, K. I., Yasukawa, K. & Utsumi, H., Mar 1 2009, In : Yakugaku Zasshi. 129, 3, p. 273-278 6 p.

Research output: Contribution to journalReview article

Oxidation-Reduction
Magnetic Resonance Spectroscopy
Free Radicals
Pharmaceutical Preparations
Process Assessment (Health Care)
46 Citations (Scopus)

Analysis of small smounts of D-Amino acids and the study of their physiological functions in mammals

Hamase, K., Morikawa, A., Etoh, S., Tojo, Y., Miyoshi, Y. & Zaitsu, K., Aug 2009, In : analytical sciences. 25, 8, p. 961-968 8 p.

Research output: Contribution to journalReview article

Mammals
Amino Acids
Enantiomers
Manuscripts
Biomarkers
2008

Development of highly selective and sensitive fluorescent and chemiluminescent reagents

Nakazono, M., Jun 1 2008, In : Yakugaku Zasshi. 128, 6, p. 919-924 6 p.

Research output: Contribution to journalReview article

Luminescence
Polyphenols
Fluorescence
Luminol
Dendrimers
2007
11 Citations (Scopus)

Are free radical reactions increased in the diabetic eye?

Yamato, M., Matsumoto, S., Ura, K., Yamada, K-I., Naganuma, T., Inoguchi, T., Watanabe, T. & Utsumi, H., Mar 1 2007, In : Antioxidants and Redox Signaling. 9, 3, p. 367-373 7 p.

Research output: Contribution to journalReview article

Free radical reactions
Electron Spin Resonance Spectroscopy
Streptozocin
Free Radicals
Reactive Oxygen Species
24 Citations (Scopus)
Mammals
Amino Acids
Enantiomers
Periodicity
Rats
2006
22 Citations (Scopus)

Application of unnatural oligonucleotides to chemical modification of gene expression

Sasaki, S. & Nagatsugi, F., Dec 1 2006, In : Current Opinion in Chemical Biology. 10, 6, p. 615-621 7 p.

Research output: Contribution to journalReview article

Chemical modification
Gene expression
Oligonucleotides
Gene Expression
Molecules
2005
63 Citations (Scopus)

Sensitive determination of D-amino acids in mammals and the effect of D-amino-acid oxidase activity on their amounts

Hamase, K., Konno, R., Morikawa, A. & Zaitsu, K., Sep 1 2005, In : Biological and Pharmaceutical Bulletin. 28, 9, p. 1578-1584 7 p.

Research output: Contribution to journalReview article

D-Amino-Acid Oxidase
Mammals
Amino Acids
Mutant Strains Mice
D-Aspartic Acid
2004
10 Citations (Scopus)

Chemical tools for targeted mutagenesis of DNA based on triple helix formation

Nagatsugi, F. & Sasaki, S., Apr 1 2004, In : Biological and Pharmaceutical Bulletin. 27, 4, p. 463-467 5 p.

Research output: Contribution to journalReview article

Oligonucleotides
Mutagenesis
DNA
Mutation
Alkylation
2002

Creation of functional recognition molecules for chemical modification of gene expression

Sasaki, S., Dec 1 2002, In : Yakugaku Zasshi. 122, 12, p. 1081-1093 13 p.

Research output: Contribution to journalReview article

Point Mutation
Nucleic Acids
Gene Expression
DNA
2-amino-6-vinylpurine
157 Citations (Scopus)

D-amino acids in mammals and their diagnostic value

Hamase, K., Morikawa, A. & Zaitsu, K., Dec 5 2002, In : Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 781, 1-2, p. 73-91 19 p.

Research output: Contribution to journalReview article

Mammals
Amino Acids
Tissue
Tissue Distribution
2001
19 Citations (Scopus)
Modifier Genes
Alkylating Agents
Oligonucleotides
Cytidine
Efficiency