Department of Molecular and Cellular Biology

Research Output 1989 2020

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2020

Long-term maintenance of functional primary human hepatocytes using small molecules

Katsuda, T., Kawamata, M., Inoue, A., Yamaguchi, T., Abe, M. & Ochiya, T., Jan 1 2020, In : FEBS Letters. 594, 1, p. 114-125 12 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP3A
Hepatocytes
Drug Discovery
Molecules
Cytochrome P-450 CYP1A2
2019
1 Citation (Scopus)

A 23 gene–based molecular prognostic score precisely predicts overall survival of breast cancer patients

Shimizu, H. & Nakayama, K., Aug 1 2019, In : EBioMedicine. 46, p. 150-159 10 p.

Research output: Contribution to journalArticle

Open Access
Genes
Breast Neoplasms
Survival
RNA Sequence Analysis
Organized Financing

A fail-safe system to prevent oncogenesis by senescence is targeted by SV40 small T antigen

Oshikawa, K., Matsumoto, M., Kodama, M., Shimizu, H. & Nakayama, K. I., Jan 1 2019, (Accepted/In press) In : Oncogene.

Research output: Contribution to journalArticle

Simian virus 40
Viral Tumor Antigens
Carcinogenesis
Oncogenes
Heterochromatin
2 Citations (Scopus)

Disruption of FBXL5-mediated cellular iron homeostasis promotes liver carcinogenesis

Muto, Y., Moroishi, T., Ichihara, K., Nishiyama, M., Shimizu, H., Eguchi, H., Moriya, K., Koike, K., Mimori, K., Mori, M., Katayama, Y. & Nakayama, K. I., Apr 1 2019, In : Journal of Experimental Medicine. 216, 4, p. 950-965 16 p.

Research output: Contribution to journalArticle

Open Access
Carcinogenesis
Homeostasis
Iron
Iron Overload
Liver

Frequent Detection of Pituitary-Derived PrPres in Human Prion Diseases

Honda, H., Matsumoto, M., Shijo, M., Hamasaki, H., Sadashima, S., Suzuki, S. O., Aishima, S., Kai, K., Nakayama, K. I., Sasagasako, N. & Iwaki, T., Oct 1 2019, In : Journal of neuropathology and experimental neurology. 78, 10, p. 922-929 8 p.

Research output: Contribution to journalArticle

Prion Diseases
Human Growth Hormone
Pituitary Gland
Molecular Weight
Dura Mater

Generation of Nanog reporter mice that distinguish pluripotent stem cells from unipotent primordial germ cells

Terada, M., Kawamata, M., Kimura, R., Sekiya, S., Nagamatsu, G., Hayashi, K., Horisawa, K. & Suzuki, A., Nov 1 2019, In : Genesis. 57, 11-12, e23334.

Research output: Contribution to journalArticle

Pluripotent Stem Cells
Germ Cells
Embryonic Stem Cells
Genetic Promoter Regions
Transgenic Mice
1 Citation (Scopus)

New High-Throughput Screening Identifies Compounds That Reduce Viability Specifically in Liver Cancer Cells That Express High Levels of SALL4 by Inhibiting Oxidative Phosphorylation

Tan, J. L., Li, F., Yeo, J. Z., Yong, K. J., Bassal, M. A., Ng, G. H., Lee, M. Y., Leong, C. Y., Tan, H. K., Wu, C. S., Liu, B. H., Chan, T. H., Tan, Z. H., Chan, Y. S., Wang, S., Lim, Z. H., Toh, T. B., Hooi, L., Low, K. N., Ma, S. & 17 others, Kong, N. R., Stein, A. J., Wu, Y., Thangavelu, M. T., Suzuki, A., Periyasamy, G., Asara, J. M., Dan, Y. Y., Bonney, G. K., Chow, E. K., Lu, G. D., Ng, H. H., Kanagasundaram, Y., Ng, S. B., Tam, W. L., Tenen, D. G. & Chai, L., Dec 2019, In : Gastroenterology. 157, 6, p. 1615-1629.e17

Research output: Contribution to journalArticle

Open Access
Oxidative Phosphorylation
Liver Neoplasms
Oligomycins
Heterografts
Neoplasms

Pillars Article: Restoration of T Cell Development in RAG-2-Deficient Mice by Functional TCR Transgenes. Science. 1993. 259: 822-825

Shinkai, Y., Koyasu, S., Nakayama, K. I., Murphy, K. M., Loh, D. Y., Reinherz, E. L. & Alt, F. W., Mar 1 2019, In : Journal of immunology (Baltimore, Md. : 1950). 202, 5, p. 1317-1320 4 p.

Research output: Contribution to journalArticle

Transgenes
T-Lymphocytes
5 Citations (Scopus)

Prevention of cancer dormancy by Fbxw7 ablation eradicates disseminated tumor cells

Shimizu, H., Takeishi, S., Nakatsumi, H. & Nakayama, K. I., Feb 21 2019, In : JCI Insight. 4, 4

Research output: Contribution to journalArticle

Neoplasms
Breast Neoplasms
Drug Therapy
Paclitaxel
Heterografts

Reconstruction of global regulatory network from signaling to cellular functions using phosphoproteomic data

Kawata, K., Yugi, K., Hatano, A., Kokaji, T., Tomizawa, Y., Fujii, M., Uda, S., Kubota, H., Matsumoto, M., Nakayama, K. I. & Kuroda, S., Jan 2019, In : Genes to Cells. 24, 1, p. 82-93 12 p.

Research output: Contribution to journalArticle

Insulin
Phosphorylation
Proteins
Protein Kinases
Hepatocellular Carcinoma

SCFFbxw7 ubiquitylates KLF7 for degradation in a manner dependent on GSK-3-mediated phosphorylation

Sugiyama, S., Yumimoto, K., Inoue, I. & Nakayama, K. I., May 2019, In : Genes to Cells. 24, 5, p. 354-365 12 p.

Research output: Contribution to journalArticle

Glycogen Synthase Kinase 3
Ligases
Ubiquitin
Phosphorylation
Maintenance

The pericentromeric protein shugoshin 2 cooperates with HSF1 in heat shock response and RNA Pol II recruitment

Takii, R., Fujimoto, M., Matsumoto, M., Srivastava, P., Katiyar, A., Nakayama, K. I. & Nakai, A., Dec 16 2019, In : EMBO Journal. 38, 24, e102566.

Research output: Contribution to journalArticle

Heat-Shock Response
RNA Polymerase II
Proteins
Shock
Phosphorylation
3 Citations (Scopus)

Zfp281 Shapes the Transcriptome of Trophoblast Stem Cells and Is Essential for Placental Development

Ishiuchi, T., Ohishi, H., Sato, T., Kamimura, S., Yorino, M., Abe, S., Suzuki, A., Wakayama, T., Suyama, M. & Sasaki, H., May 7 2019, In : Cell Reports. 27, 6, p. 1742-1754.e6

Research output: Contribution to journalArticle

Open Access
Placentation
Trophoblasts
Stem cells
Transcriptome
Stem Cells
2018

Acetaldehyde administrationinduces salsolinol formation in vivo in the dorsal striatum of Aldh2-knockout and C57BL/6N mice

Ito, A., Jamal, M., Ameno, K., Tanaka, N., Takakura, A., Kawamoto, T., Kitagawa, K., Nakayama, K., Matsumoto, A., Miki, T. & Kinoshita, H., Oct 15 2018, In : Neuroscience Letters. 685, p. 50-54 5 p.

Research output: Contribution to journalArticle

Acetaldehyde
Inbred C57BL Mouse
Knockout Mice
Dopamine
Serotonin
8 Citations (Scopus)

Bcl11b sets pro-T cell fate by site-specific cofactor recruitment and by repressing Id2 and Zbtb16

Hosokawa, H., Romero-Wolf, M., Yui, M. A., Ungerbäck, J., Quiloan, M. L. G., Matsumoto, M., Nakayama, K., Tanaka, T. & Rothenberg, E. V., Dec 1 2018, In : Nature Immunology. 19, 12, p. 1427-1440 14 p.

Research output: Contribution to journalArticle

T-Lymphocytes
Gene Regulatory Networks
Genes
Transcription Factors
Proteomics
2 Citations (Scopus)

Cell Aggregation Culture Induces Functional Differentiation of Induced Hepatocyte-like Cells through Activation of Hippo Signaling

Yamamoto, J., Udono, M., Miura, S., Sekiya, S. & Suzuki, A., Oct 2 2018, In : Cell Reports. 25, 1, p. 183-198 16 p.

Research output: Contribution to journalArticle

Cell Aggregation
Hepatocytes
Agglomeration
Cell Culture Techniques
Chemical activation
4 Citations (Scopus)
Autistic Disorder
Brain
Biological Phenomena
Therapeutics
Autism Spectrum Disorder
11 Citations (Scopus)

Combined mutation of Apc, Kras, and Tgfbr2 effectively drives metastasis of intestinal cancer

Sakai, E., Nakayama, M., Oshima, H., Kouyama, Y., Niida, A., Fujii, S., Ochiai, A., Nakayama, K. I., Mimori, K., Suzuki, Y., Hong, C. P., Ock, C. Y., Kim, S. J. & Oshima, M., Mar 1 2018, In : Cancer Research. 78, 5, p. 1334-1346 13 p.

Research output: Contribution to journalArticle

Intestinal Neoplasms
Neoplasm Metastasis
Mutation
Colorectal Neoplasms
Organoids
12 Citations (Scopus)

Decreased Brain pH as a Shared Endophenotype of Psychiatric Disorders

Hagihara, H., Catts, V. S., Katayama, Y., Shoji, H., Takagi, T., Huang, F. L., Nakao, A., Mori, Y., Huang, K. P., Ishii, S., Graef, I. A., Nakayama, K. I., Shannon Weickert, C. & Miyakawa, T., Feb 1 2018, In : Neuropsychopharmacology. 43, 3, p. 459-468 10 p.

Research output: Contribution to journalArticle

Endophenotypes
Psychiatry
Bipolar Disorder
Brain
Schizophrenia
3 Citations (Scopus)

Degradation of the endoplasmic reticulum–anchored transcription factor MyRF by the ubiquitin ligase SCFFbxw7 in a manner dependent on the kinase GSK-3

Nakayama, S., Yumimoto, K., Kawamura, A. & Nakayama, K. I., Jan 1 2018, In : Journal of Biological Chemistry. 293, 15, p. 5705-5714 10 p.

Research output: Contribution to journalArticle

Glycogen Synthase Kinase 3
Ligases
Myelin Sheath
Ubiquitin
Transcription Factors
2 Citations (Scopus)

GRWD1 regulates ribosomal protein L23 levels via the ubiquitin-proteasome system

Watanabe, S., Fujiyama, H., Takafuji, T., Kayama, K., Matsumoto, M., Nakayama, K. I., Yoshida, K., Sugimoto, N. & Fujita, M., Aug 1 2018, In : Journal of Cell Science. 131, 15

Research output: Contribution to journalArticle

Ribosomal Proteins
Proteasome Endopeptidase Complex
Ubiquitin
Glutamic Acid
Down-Regulation
5 Citations (Scopus)

Inhibiting Skp2 E3 ligase suppresses bleomycin-induced pulmonary fibrosis

Mikamo, M., Kitagawa, K., Sakai, S., Uchida, C., Ohhata, T., Nishimoto, K., Niida, H., Suzuki, S., Nakayama, K. I., Inui, N., Suda, T. & Kitagawa, M., Feb 6 2018, In : International journal of molecular sciences. 19, 2, 474.

Research output: Contribution to journalArticle

fibrosis
Ubiquitin-Protein Ligases
Pulmonary Fibrosis
Bleomycin
Cells
1 Citation (Scopus)

Nuclear–cytoplasmic shuttling protein PP2AB56 contributes to mTORC1-dependent dephosphorylation of FOXK1

Nakatsumi, H., Oka, T., Higa, T., Shirane, M. & Nakayama, K., Jul 1 2018, In : Genes to Cells. 23, 7, p. 599-605 7 p.

Research output: Contribution to journalArticle

Proteins
Protein Phosphatase 2
Signal Transduction
Forkhead Transcription Factors
mechanistic target of rapamycin complex 1
1 Citation (Scopus)

Peroxisome biogenesis deficiency attenuates the BDNF-TrkB pathway-mediated development of the cerebellum

Abe, Y., Honsho, M., Itoh, R., Kawaguchi, R., Fujitani, M., Fujiwara, K., Hirokane, M., Matsuzaki, T., Nakayama, K., Ohgi, R., Marutani, T., Nakayama, K. I., Yamashita, T. & Fujiki, Y., Jan 1 2018, In : Life Science Alliance. 1, 6

Research output: Contribution to journalArticle

neurotrophins
Peroxisomes
Brain-Derived Neurotrophic Factor
cerebellum
peroxisomes
21 Citations (Scopus)

PKM1 Confers Metabolic Advantages and Promotes Cell-Autonomous Tumor Cell Growth

Morita, M., Sato, T., Nomura, M., Sakamoto, Y., Inoue, Y., Tanaka, R., Ito, S., Kurosawa, K., Yamaguchi, K., Sugiura, Y., Takizaki, H., Yamashita, Y., Katakura, R., Sato, I., Kawai, M., Okada, Y., Watanabe, H., Kondoh, G., Matsumoto, S., Kishimoto, A. & 12 others, Obata, M., Matsumoto, M., Fukuhara, T., Motohashi, H., Suematsu, M., Komatsu, M., Nakayama, K. I., Watanabe, T., Soga, T., Shima, H., Maemondo, M. & Tanuma, N., Mar 12 2018, In : Cancer Cell. 33, 3, p. 355-367.e7

Research output: Contribution to journalArticle

Small Cell Lung Carcinoma
Growth
Neoplasms
Protein Isoforms
Neuroendocrine Tumors
4 Citations (Scopus)

Prolonged inhibition of hepatocellular carcinoma cell proliferation by combinatorial expression of defined transcription factors

Takashima, Y., Horisawa, K., Udono, M., Ohkawa, Y. & Suzuki, A., Nov 1 2018, In : Cancer Science. 109, 11, p. 3543-3553 11 p.

Research output: Contribution to journalArticle

Hepatocellular Carcinoma
Transcription Factor 3
Transcription Factors
Cell Proliferation
Cell Line

The Autism-Related Protein CHD8 Cooperates with C/EBPβ to Regulate Adipogenesis

Kita, Y., Katayama, Y., Shiraishi, T., Oka, T., Sato, T., Suyama, M., Ohkawa, Y., Miyata, K., Oike, Y., Shirane, M., Nishiyama, M. & Nakayama, K. I., May 15 2018, In : Cell Reports. 23, 7, p. 1988-2000 13 p.

Research output: Contribution to journalArticle

CCAAT-Enhancer-Binding Proteins
Adipogenesis
Autistic Disorder
White Adipose Tissue
Peroxisome Proliferator-Activated Receptors
1 Citation (Scopus)

TMEM55B contributes to lysosomal homeostasis and amino acid–induced mTORC1 activation

Hashimoto, Y., Shirane, M. & Nakayama, K. I., Jun 2018, In : Genes to Cells. 23, 6, p. 418-434 17 p.

Research output: Contribution to journalArticle

Vacuolar Proton-Translocating ATPases
Homeostasis
Protons
Membranes
Lipids
16 Citations (Scopus)

Transcription Factor PU.1 Represses and Activates Gene Expression in Early T Cells by Redirecting Partner Transcription Factor Binding

Hosokawa, H., Ungerbäck, J., Wang, X., Matsumoto, M., Nakayama, K. I., Cohen, S. M., Tanaka, T. & Rothenberg, E. V., Jun 19 2018, In : Immunity. 48, 6, p. 1119-1134.e7

Research output: Contribution to journalArticle

Transcription Factors
T-Lymphocytes
Gene Expression
Genes
Binding Sites

Trans-omic Analysis Reveals Selective Responses to Induced and Basal Insulin across Signaling, Transcriptional, and Metabolic Networks

Kawata, K., Hatano, A., Yugi, K., Sano, T., Fujii, M., Tomizawa, Y., Kokaji, T., Tanaka, K. Y., Uda, S., Suzuki, Y., Matsumoto, M., Nakayama, K., Saitoh, K., Kato, K., Ueno, A., Ohishi, M., Hirayama, A., Soga, T. & Kuroda, S., 2018, In : iScience. 7, p. 212-229

Research output: Contribution to journalArticle

Gene Regulatory Networks
Metabolic Networks and Pathways
Insulin
Immediate-Early Genes
Metabolomics
7 Citations (Scopus)

Trans-omic Analysis Reveals Selective Responses to Induced and Basal Insulin across Signaling, Transcriptional, and Metabolic Networks

Kawata, K., Hatano, A., Yugi, K., Kubota, H., Sano, T., Fujii, M., Tomizawa, Y., Kokaji, T., Tanaka, K. Y., Uda, S., Suzuki, Y., Matsumoto, M., Nakayama, K. I., Saitoh, K., Kato, K., Ueno, A., Ohishi, M., Hirayama, A., Soga, T. & Kuroda, S., Sep 28 2018, In : iScience. 7, p. 212-229 18 p.

Research output: Contribution to journalArticle

Open Access
Gene Regulatory Networks
Metabolic Networks and Pathways
insulin
Insulin
Immediate-Early Genes
2017
25 Citations (Scopus)

A large-scale targeted proteomics assay resource based on an in vitro human proteome

Matsumoto, M., Matsuzaki, F., Oshikawa, K., Goshima, N., Mori, M., Kawamura, Y., Ogawa, K., Fukuda, E., Nakatsumi, H., Natsume, T., Fukui, K., Horimoto, K., Nagashima, T., Funayama, R., Nakayama, K. & Nakayama, K. I., Feb 28 2017, In : Nature Methods. 14, 3, p. 251-258 8 p.

Research output: Contribution to journalArticle

Proteome
Proteomics
Assays
Proteins
Monitoring
10 Citations (Scopus)

Chd2 regulates chromatin for proper gene expression toward differentiation in mouse embryonic stem cells

Semba, Y., Harada, A., Maehara, K., Oki, S., Meno, C., Ueda, J., Yamagata, K., Suzuki, A., Onimaru, M., Nogami, J., Okada, S., Akashi, K. & Ohkawa, Y., Sep 1 2017, In : Nucleic acids research. 45, 15, p. 8758-8772 15 p.

Research output: Contribution to journalArticle

DNA Helicases
Embryonic Stem Cells
Chromatin
Gene Expression
Histones
50 Citations (Scopus)

Conversion of Terminally Committed Hepatocytes to Culturable Bipotent Progenitor Cells with Regenerative Capacity

Katsuda, T., Kawamata, M., Hagiwara, K., Takahashi, R. U., Yamamoto, Y., Camargo, F. D. & Ochiya, T., Jan 5 2017, In : Cell stem cell. 20, 1, p. 41-55 15 p.

Research output: Contribution to journalArticle

Hepatocytes
Stem Cells
Liver
Liver Regeneration
Regenerative Medicine
8 Citations (Scopus)

Essential role of FBXL5-mediated cellular iron homeostasis in maintenance of hematopoietic stem cells

Muto, Y., Nishiyama, M., Nita, A., Moroishi, T. & Nakayama, K. I., Jul 17 2017, In : Nature communications. 8, 16114.

Research output: Contribution to journalArticle

homeostasis
stem cells
Hematopoietic Stem Cells
Stem cells
maintenance
6 Citations (Scopus)

FBXL5 inactivation in mouse brain induces aberrant proliferation of neural stem progenitor cells

Yamauchi, T., Nishiyama, M., Moroishi, T., Kawamura, A. & Nakayama, K. I., Apr 1 2017, In : Molecular and cellular biology. 37, 8, e00470-16.

Research output: Contribution to journalArticle

Neural Stem Cells
Stem Cells
Iron
Iron Regulatory Protein 2
Brain
10 Citations (Scopus)

Generation of Mouse and Human Organoid-Forming Intestinal Progenitor Cells by Direct Lineage Reprogramming

Miura, S. & Suzuki, A., Oct 5 2017, In : Cell stem cell. 21, 4, p. 456-471.e5

Research output: Contribution to journalArticle

Organoids
Cell Lineage
Stem Cells
Intestines
Transcription Factors
11 Citations (Scopus)

GRWD1 negatively regulates p53 via the RPL11–MDM2 pathway and promotes tumorigenesis

Kayama, K., Watanabe, S., Takafuji, T., Tsuji, T., Hironaka, K., Matsumoto, M., Nakayama, K. I., Enari, M., Kohno, T., Shiraishi, K., Kiyono, T., Yoshida, K., Sugimoto, N. & Fujita, M., Jan 1 2017, In : EMBO Reports. 18, 1, p. 123-137 15 p.

Research output: Contribution to journalArticle

Glutamic Acid
Carcinogenesis
Ligases
Ubiquitin
WD40 Repeats
42 Citations (Scopus)

Hippo Signaling Suppresses Cell Ploidy and Tumorigenesis through Skp2

Zhang, S., Chen, Q., Liu, Q., Li, Y., Sun, X., Hong, L., Ji, S., Liu, C., Geng, J., Zhang, W., Lu, Z., Yin, Z. Y., Zeng, Y., Lin, K. H., Wu, Q., Li, Q., Nakayama, K., Nakayama, K. I., Deng, X., Johnson, R. L. & 4 others, Zhu, L., Gao, D., Chen, L. & Zhou, D., May 8 2017, In : Cancer Cell. 31, 5, p. 669-684.e7

Research output: Contribution to journalArticle

Polyploidy
Ploidies
Carcinogenesis
Cyclin-Dependent Kinase Inhibitor p27
Ubiquitin-Protein Ligases

Hypoxia-inducible factor-2α stabilizes the von Hippel-Lindau (VHL) disease suppressor, Mybrelated protein 2

Okumura, F., Joo-Okumura, A., Nakatsukasa, K. & Kamura, T., Apr 2017, In : PloS one. 12, 4, e0175593.

Research output: Contribution to journalArticle

Open Access
von Hippel-Lindau Disease
hypoxia
Proteins
proteins
Down-Regulation
1 Citation (Scopus)

In vitro reconstitution of breast cancer heterogeneity with multipotent cancer stem cells using small molecules

Kawamata, M., Katsuda, T., Yamada, Y. & Ochiya, T., Jan 22 2017, In : Biochemical and Biophysical Research Communications. 482, 4, p. 750-757 8 p.

Research output: Contribution to journalArticle

Multipotent Stem Cells
Neoplastic Stem Cells
Stem cells
Tumors
Breast Neoplasms
146 Citations (Scopus)

MTORC1 and muscle regeneration are regulated by the LINC00961-encoded SPAR polypeptide

Matsumoto, A., Pasut, A., Matsumoto, M., Yamashita, R., Fung, J., Monteleone, E., Saghatelian, A., Nakayama, K. I., Clohessy, J. G. & Pandolfi, P. P., Jan 12 2017, In : Nature. 541, 7636, p. 228-232 5 p.

Research output: Contribution to journalArticle

Long Noncoding RNA
Regeneration
Amino Acids
Muscles
Peptides

mTORC1 and muscle regeneration are regulated by the LINC00961-encoded SPAR polypeptide.

Matsumoto, A., Pasut, A., Matsumoto, M., Yamashita, R., Fung, J., Monteleone, E., Saghatelian, A., Nakayama, K., Clohessy, J. & Pandolfi, P. P., 2017, In : Nature. 541, 7636, p. 228 5 p., 541.

Research output: Contribution to journalArticle

Long Noncoding RNA
Regeneration
Amino Acids
Muscles
Peptides
15 Citations (Scopus)

Noncanonical Pathway for Regulation of CCL2 Expression by an mTORC1-FOXK1 Axis Promotes Recruitment of Tumor-Associated Macrophages

Nakatsumi, H., Matsumoto, M. & Nakayama, K. I., Nov 28 2017, In : Cell Reports. 21, 9, p. 2471-2486 16 p.

Research output: Contribution to journalArticle

CC Chemokines
Macrophages
Tumors
Ligands
Neoplasms
10 Citations (Scopus)

NOTCH2 Hajdu-Cheney Mutations Escape SCFFBW7-Dependent Proteolysis to Promote Osteoporosis

Fukushima, H., Shimizu, K., Watahiki, A., Hoshikawa, S., Kosho, T., Oba, D., Sakano, S., Arakaki, M., Yamada, A., Nagashima, K., Okabe, K., Fukumoto, S., Jimi, E., Bigas, A., Nakayama, K. I., Nakayama, K., Aoki, Y., Wei, W. & Inuzuka, H., Nov 16 2017, In : Molecular Cell. 68, 4, p. 645-658.e5

Research output: Contribution to journalArticle

Hajdu-Cheney Syndrome
Proteolysis
Osteoporosis
Osteoclasts
Mutation
3 Citations (Scopus)

Sez6l2 regulates phosphorylation of ADD and neuritogenesis

Yaguchi, H., Yabe, I., Takahashi, H., Watanabe, M., Nomura, T., Kano, T., Matsumoto, M., Nakayama, K. I., Watanabe, M. & Hatakeyama, S., Dec 9 2017, In : Biochemical and Biophysical Research Communications. 494, 1-2, p. 234-241 8 p.

Research output: Contribution to journalArticle

Phosphorylation
Seizures
Glutamate Receptors
Cerebellar Ataxia
Signal transduction
5 Citations (Scopus)

SRRM4-dependent neuron-specific alternative splicing of protrudin transcripts regulates neurite outgrowth

Ohnishi, T., Shirane, M. & Nakayama, K. I., Jan 20 2017, In : Scientific reports. 7, 41130.

Research output: Contribution to journalArticle

Alternative Splicing
Exons
Neurons
Nervous System
RNA Precursors
16 Citations (Scopus)

Structural basis for the assembly of the Ragulator-Rag GTPase complex

Yonehara, R., Nada, S., Nakai, T., Nakai, M., Kitamura, A., Ogawa, A., Nakatsumi, H., Nakayama, K. I., Li, S., Standley, D. M., Yamashita, E., Nakagawa, A. & Okada, M., Dec 1 2017, In : Nature communications. 8, 1, 1625.

Research output: Contribution to journalArticle

lysosomes
GTP Phosphohydrolases
assembly
Lysosomes
nutrients
13 Citations (Scopus)

The SCFβ-TRCP E3 ubiquitin ligase complex targets Lipin1 for ubiquitination and degradation to promote hepatic lipogenesis

Shimizu, K., Fukushima, H., Ogura, K., Lien, E. C., Nihira, N. T., Zhang, J., North, B. J., Guo, A., Nagashima, K., Nakagawa, T., Hoshikawa, S., Watahiki, A., Okabe, K., Yamada, A., Toker, A., Asara, J. M., Fukumoto, S., Nakayama, K. I., Nakayama, K., Inuzuka, H. & 1 others, Wei, W., Jan 3 2017, In : Science Signaling. 10, 460

Research output: Contribution to journalArticle

Lipogenesis
Ubiquitin-Protein Ligases
Ubiquitination
Sterol Regulatory Element Binding Proteins
Degradation
2 Citations (Scopus)

Ubiquitin ligase SPSB4 diminishes cell repulsive responses mediated by EphB2

Okumura, F., Joo-Okumura, A., Obara, K., Petersen, A., Nishikimi, A., Fukui, Y., Nakatsukasa, K. & Kamura, T., Nov 15 2017, In : Molecular biology of the cell. 28, 24, p. 3532-3541 10 p.

Research output: Contribution to journalArticle

Ligases
Ubiquitin
Matrix Metalloproteinases
EphB2 Receptors
Eph Family Receptors