Department of Molecular and Cellular Biology

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Dynamic three-dimensional morphogenesis of intrahepatic bile ducts in mouse liver development

Takashima, Y., Terada, M., Kawabata, M. & Suzuki, A., Mar 1 2015, In : Hepatology. 61, 3, p. 1003-1011 9 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Early embryonic death in mice lacking the β-catenin-binding protein duplin

Nishiyama, M., Nakayama, K., Tsunematsu, R., Tsukiyama, T., Kikuchi, A. & Nakayama, K. I., Oct 1 2004, In : Molecular and cellular biology. 24, 19, p. 8386-8394 9 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

Effects of 5-week ethanol feeding on the liver of aldehyde dehydrogenase 2 knockout mice

Matsumoto, A., Kawamoto, T., Mutoh, F., Isse, T., Oyama, T., Kitagawa, K., Nakayama, K. I. & Ichiba, M., Oct 1 2008, In : Pharmacogenetics and Genomics. 18, 10, p. 847-852 6 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

EGF signaling activates proliferation and blocks apoptosis of mouse and human intestinal stem/progenitor cells in long-term monolayer cell culture

Suzuki, A., Sekiya, S., Gunshima, E., Fujii, S. & Taniguchi, H., Oct 1 2010, In : Laboratory Investigation. 90, 10, p. 1425-1436 12 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

Endosomal escape efficiency of fusogenic B18 and B55 peptides fused with anti-EGFR single chain Fv as estimated by nuclear translocation

Niikura, K., Horisawa, K. & Doi, N., Jan 1 2016, In : Journal of biochemistry. 159, 1, p. 123-132 10 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Enhanced Th2 cell-mediated allergic inflammation in Tyk2-deficient mice

Seto, Y., Nakajima, H., Suto, A., Shimoda, K., Saito, Y., Nakayama, K. I. & Iwamoto, I., Jan 15 2003, In : Journal of Immunology. 170, 2, p. 1077-1083 7 p.

Research output: Contribution to journalArticle

50 Citations (Scopus)

Essential role of FBXL5-mediated cellular iron homeostasis in maintenance of hematopoietic stem cells

Muto, Y., Nishiyama, M., Nita, A., Moroishi, T. & Nakayama, K. I., Jul 17 2017, In : Nature communications. 8, 16114.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Essential role of the prosurvival bcl-2 homologue A1 in mast cell survival after allergic activation

Xiang, Z., Ahmed, A. A., Möller, C., Nakayama, K. I., Hatakeyama, S. & Nilsson, G., Dec 3 2001, In : Journal of Experimental Medicine. 194, 11, p. 1561-1569 9 p.

Research output: Contribution to journalArticle

91 Citations (Scopus)

Estrogens Down-regulate p27Kip1 in Breast Cancer Cells through Skp2 and through Nuclear Export Mediated by the ERK Pathway

Foster, J. S., Fernando, R. I., Ishida, N., Nakayama, K. I. & Wimalasena, J., Oct 17 2003, In : Journal of Biological Chemistry. 278, 42, p. 41355-41366 12 p.

Research output: Contribution to journalArticle

87 Citations (Scopus)

Ethanol metabolism in ALDH2 knockout mice - Blood acetate levels

Kiyoshi, A., Weihuan, W., Mostofa, J., Mitsuru, K., Toyoshi, I., Toshihiro, K., Kyoko, K., Keiichi, N., Iwao, I. & Hiroshi, K., Apr 1 2009, In : Legal Medicine. 11, SUPPL. 1, p. S413-S415

Research output: Contribution to journalArticle

15 Citations (Scopus)

Expression of cdc2 and p27(KIP1) phosphorylation in mitotic cells of the human retinoblastoma

Kase, S., Yoshida, K., Ohgami, K., Shiratori, K., Suzuki, Y., Nakayama, K. I. & Ohno, S., Mar 1 2006, In : International journal of molecular medicine. 17, 3, p. 465-468 4 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
38 Citations (Scopus)

Ex vivo maintenance of hematopoietic stem cells by quiescence induction through Fbxw7α overexpression

Iriuchishima, H., Takubo, K., Matsuoka, S., Onoyama, I., Nakayama, K. I., Nojima, Y. & Suda, T., Feb 24 2011, In : Blood. 117, 8, p. 2373-2377 5 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

F-box and WD repeat domain-containing-7 (Fbxw7) protein targets endoplasmic reticulum-anchored osteogenic and chondrogenic transcriptional factors for degradation

Yumimoto, K., Matsumoto, M., Onoyama, I., Imaizumi, K. & Nakayama, K. I., Oct 4 2013, In : Journal of Biological Chemistry. 288, 40, p. 28488-28502 15 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

F-box protein FBXW7 inhibits cancer metastasis in a non-cell-autonomous manner

Yumimoto, K., Akiyoshi, S., Ueo, H., Sagara, Y., Onoyama, I., Ueo, H., Ohno, S., Mori, M., Mimori, K. & Nakayama, K. I., Feb 2 2015, In : Journal of Clinical Investigation. 125, 2, p. 621-635 15 p.

Research output: Contribution to journalArticle

56 Citations (Scopus)

Fbw7 and p53 cooperatively suppress advanced and chromosomally unstable intestinal cancer

Grim, J. E., Knoblaugh, S. E., Guthrie, K. A., Hagar, A., Swanger, J., Hespelt, J., Delrow, J. J., Small, T., Grady, W. M., Nakayama, K. I. & Clurman, B. E., Jun 1 2012, In : Molecular and cellular biology. 32, 11, p. 2160-2167 8 p.

Research output: Contribution to journalArticle

51 Citations (Scopus)

Fbw7 targets GATA3 through cyclin-dependent kinase 2-dependent proteolysis and contributes to regulation of T-cell development

Kitagawa, K., Shibat, K., Matsumoto, A., Matsumoto, M., Ohhata, T., Nakayama, K. I., Niida, H. & Kitagawa, M., Jul 2014, In : Molecular and cellular biology. 34, 14, p. 2732-2744 13 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

FBXL12-mediated degradation of ALDH3 is essential for trophoblast differentiation during placental development

Nishiyama, M., Nita, A., Yumimoto, K. & Nakayama, K. I., Nov 2015, In : STEM CELLS. 33, 11, p. 3327-3340 14 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

FBXL12 regulates T-cell differentiation in a cell-autonomous manner

Nita, A., Nishiyama, M., Muto, Y. & Nakayama, K., May 1 2016, In : Genes to Cells. 21, 5, p. 517-524 8 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

FBXL21 regulates oscillation of the circadian clock through ubiquitination and stabilization of cryptochromes

Hirano, A., Yumimoto, K., Tsunematsu, R., Matsumoto, M., Oyama, M., Kozuka-Hata, H., Nakagawa, T., Lanjakornsiripan, D., Nakayama, K. I. & Fukada, Y., Feb 28 2013, In : Cell. 152, 5, p. 1106-1118 13 p.

Research output: Contribution to journalArticle

131 Citations (Scopus)

FBXL5 inactivation in mouse brain induces aberrant proliferation of neural stem progenitor cells

Yamauchi, T., Nishiyama, M., Moroishi, T., Kawamura, A. & Nakayama, K. I., Apr 1 2017, In : Molecular and cellular biology. 37, 8, e00470-16.

Research output: Contribution to journalArticle

7 Citations (Scopus)

FBXO21 mediates the ubiquitylation and proteasomal degradation of EID1

Watanabe, K., Yumimoto, K. & Nakayama, K. I., Aug 1 2015, In : Genes to Cells. 20, 8, p. 667-674 8 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Fbxo45, a novel ubiquitin ligase, regulates synaptic activity

Tada, H., Okano, H. J., Takagi, H., Shibata, S., Yao, I., Matsumoto, M., Saiga, T., Nakayama, K. I., Kashima, H., Takahashi, T., Setou, M. & Okano, H., Feb 5 2010, In : Journal of Biological Chemistry. 285, 6, p. 3840-3849 10 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)

Fbxo45 forms a novel ubiquitin ligase complex and is required for neuronal development

Saiga, T., Fukuda, T., Matsumoto, M., Tada, H., Okano, H. J., Okano, H. & Nakayama, K. I., Jul 1 2009, In : Molecular and cellular biology. 29, 13, p. 3529-3543 15 p.

Research output: Contribution to journalArticle

68 Citations (Scopus)

Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene

Mao, J. H., Perez-Iosada, J., Wu, D., DelRosario, R., Tsunematsu, R., Nakayama, K. I., Brown, K., Bryson, S. & Balmain, A., Dec 9 2004, In : Nature. 432, 7018, p. 775-779 5 p.

Research output: Contribution to journalArticle

281 Citations (Scopus)

Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL

Matsuoka, S., Oike, Y., Onoyama, I., Iwama, A., Arai, F., Takubo, K., Mashimo, Y., Oguro, H., Nitta, E., Ito, K., Miyamoto, K., Yoshiwara, H., Hosokawa, K., Nakamura, Y., Gomei, Y., Iwasaki, H., Hayashi, Y., Matsuzaki, Y., Nakayama, K., Ikeda, Y. & 4 others, Hata, A., Chiba, S., Nakayama, K. I. & Suda, T., Apr 15 2008, In : Genes and Development. 22, 8, p. 986-991 6 p.

Research output: Contribution to journalArticle

128 Citations (Scopus)

Fbxw7 acts as an E3 ubiquitin ligase that targets c-Myb for Nemo-like kinase (NLK)-induced degradation

Kanei-Ishii, C., Nomura, T., Takagi, T., Watanabe, N., Nakayama, K. I. & Ishii, S., Nov 7 2008, In : Journal of Biological Chemistry. 283, 45, p. 30540-30548 9 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)

Fbxw7 contributes to tumor suppression by targeting multiple proteins for ubiquitin-dependent degradation

Fujii, Y., Yada, M., Nishiyama, M., Kamura, T., Takahashi, H., Tsunematsu, R., Susaki, E., Nakagawa, T., Matsumoto, A. & Nakayama, K. I., Aug 1 2006, In : Cancer Science. 97, 8, p. 729-736 8 p.

Research output: Contribution to journalArticle

51 Citations (Scopus)

Fbxw7-dependent degradation of notch is required for control of "Stemness" and neuronal-glial differentiation in neural stem cells

Matsumoto, A., Onoyama, I., Sunabori, T., Kageyama, R., Okano, H. & Nakayama, K. I., Apr 15 2011, In : Journal of Biological Chemistry. 286, 15, p. 13754-13764 11 p.

Research output: Contribution to journalArticle

63 Citations (Scopus)

FBXW7 is involved in the acquisition of the malignant phenotype in epithelial ovarian tumors

Kitade, S., Onoyama, I., Kobayashi, H., Yagi, H., Yoshida, S., Kato, M., Tsunematsu, R., Asanoma, K., Sonoda, K., Wake, N., Hata, K., Nakayama, K. I. & Kato, K., Oct 1 2016, In : Cancer Science. 107, 10, p. 1399-1405 7 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Fbxw7 regulates lipid metabolism and cell fate decisions in the mouse liver

Onoyama, I., Suzuki, A., Matsumoto, A., Tomita, K., Katagiri, H., Oike, Y., Nakayama, K. & Nakayama, K. I., Jan 4 2011, In : Journal of Clinical Investigation. 121, 1, p. 342-354 13 p.

Research output: Contribution to journalArticle

77 Citations (Scopus)

Fbxw7 suppresses cancer metastasis by inhibiting niche formation

Yumimoto, K. & Nakayama, K. I., Aug 3 2015, In : OncoImmunology. 4, 8

Research output: Contribution to journalArticle

5 Citations (Scopus)

Fbxw7β resides in the endoplasmic reticulum membrane and protects cells from oxidative stress

Matsumoto, A., Tateishi, Y., Onoyama, I., Okita, Y., Nakayama, K. & Nakayama, K., Apr 1 2011, In : Cancer Science. 102, 4, p. 749-755 7 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Fbxw8 is essential for Cul1-Cul7 complex formation and for placental development

Tsunematsu, R., Nishiyama, M., Kotoshiba, S., Saiga, T., Kamura, T. & Nakayama, K. I., Aug 1 2006, In : Molecular and cellular biology. 26, 16, p. 6157-6169 13 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)

Flow cytometric isolation and clonal identification of self-renewing bipotent hepatic progenitor cells in adult mouse liver

Suzuki, A., Sekiya, S., Onishi, M., Oshima, N., Kiyonari, H., Nakauchi, H. & Taniguchi, H., Dec 1 2008, In : Hepatology. 48, 6, p. 1964-1978 15 p.

Research output: Contribution to journalArticle

124 Citations (Scopus)

Formation of Mallory body-like inclusions and cell death induced by deregulated expression of keratin 18

Nakamichi, I., Hatakeyama, S. & Nakayama, K. I., Oct 1 2002, In : Molecular biology of the cell. 13, 10, p. 3441-3451 11 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Four mood stabilizers commonly induce FEZ1 expression in human astrocytes

Yu, Z., Ono, C., Kim, H. B., Komatsu, H., Tanabe, Y., Sakae, N., Nakayama, K., Matsuoka, H., Sora, I., Bunney, W. E. & Tomita, H., Aug 1 2011, In : Bipolar Disorders. 13, 5-6, p. 486-499 14 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Foxo3a Is Essential for Maintenance of the Hematopoietic Stem Cell Pool

Miyamoto, K., Araki, K. Y., Naka, K., Arai, F., Takubo, K., Yamazaki, S., Matsuoka, S., Miyamoto, T., Ito, K., Ohmura, M., Chen, C., Hosokawa, K., Nakauchi, H., Nakayama, K., Nakayama, K. I., Harada, M., Motoyama, N., Suda, T. & Hirao, A., Jun 7 2007, In : Cell stem cell. 1, 1, p. 101-112 12 p.

Research output: Contribution to journalArticle

574 Citations (Scopus)

Frequent detection of pituitary-derived PRPREs in human prion diseases

Honda, H., Matsumoto, M., Shijo, M., Hamasaki, H., Sadashima, S., Suzuki, S. O., Aishima, S., Kai, K., Nakayama, K. I., Sasagasako, N. & Iwaki, T., Oct 1 2019, In : Journal of neuropathology and experimental neurology. 78, 10, p. 922-929 8 p.

Research output: Contribution to journalArticle

Functional analyses of the activation loop of phototropin2 in Arabidopsis

Inoue, S. I., Matsushita, T., Tomokiyo, Y., Matsumoto, M., Nakayama, K. I., Kinoshita, T. & Shimazaki, K. I., May 1 2011, In : Plant physiology. 156, 1, p. 117-128 12 p.

Research output: Contribution to journalArticle

53 Citations (Scopus)

Functional regulation of FEZ1 by the U-box-type ubiquitin ligase E4B contributes to neuritogenesis

Okumura, F., Hatakeyama, S., Matsumoto, M., Kamura, T. & Nakayama, K. I., Dec 17 2004, In : Journal of Biological Chemistry. 279, 51, p. 53533-53543 11 p.

Research output: Contribution to journalArticle

41 Citations (Scopus)

GABAA receptor phospho-dependent modulation is regulated by phospholipase C-related inactive protein type 1, a novel protein phosphatase 1 anchoring protein

Terunuma, M., Jang, I. S., Ha, S. H., Kittler, J. T., Kanematsu, T., Jovanovic, J. N., Nakayama, K. I., Akaike, N., Ryu, S. H., Moss, S. J. & Hirata, M., Aug 11 2004, In : Journal of Neuroscience. 24, 32, p. 7074-7084 11 p.

Research output: Contribution to journalArticle

86 Citations (Scopus)

GABAA receptor subunit alteration-dependent diazepam insensitivity in the cerebellum of phospholipase C-related inactive protein knockout mice

Mizokami, A., Tanaka, H., Ishibashi, H., Umebayashi, H., Fukami, K., Takenawa, T., Nakayama, K. I., Yokoyama, T., Nabekura, J., Kanematsu, T. & Hirata, M., Jul 1 2010, In : Journal of Neurochemistry. 114, 1, p. 302-310 9 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Geminin is essential for the development of preimplantation mouse embryos

Hara, K., Nakayama, K. & Nakayama, K., Nov 1 2006, In : Genes to Cells. 11, 11, p. 1281-1293 13 p.

Research output: Contribution to journalArticle

49 Citations (Scopus)

Generation of Mouse and Human Organoid-Forming Intestinal Progenitor Cells by Direct Lineage Reprogramming

Miura, S. & Suzuki, A., Oct 5 2017, In : Cell stem cell. 21, 4, p. 456-471.e5

Research output: Contribution to journalArticle

12 Citations (Scopus)

Generation of Nanog reporter mice that distinguish pluripotent stem cells from unipotent primordial germ cells

Terada, M., Kawamata, M., Kimura, R., Sekiya, S., Nagamatsu, G., Hayashi, K., Horisawa, K. & Suzuki, A., Nov 1 2019, In : Genesis. 57, 11-12, e23334.

Research output: Contribution to journalArticle

Genetic reevaluation of the Role of F-Box proteins in cyclin D1 degradation

Kanie, T., Onoyama, I., Matsumoto, A., Yamada, M., Nakatsumi, H., Tateishi, Y., Yamamura, S., Tsunematsu, R., Matsumoto, M. & Nakayama, K. I., Feb 1 2012, In : Molecular and cellular biology. 32, 3, p. 590-605 16 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)

Glomerular differentiation in p27 and p57 double-mutant metanephroi

Tomari, S., Nagahama, H., Shu, Y., Hoshi, S., Nakayama, K., Nakayama, K. I. & Nagata, M., Dec 31 2002, In : Anatomy and Embryology. 206, 1-2, p. 31-36 6 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
24 Citations (Scopus)

GRWD1 negatively regulates p53 via the RPL11–MDM2 pathway and promotes tumorigenesis

Kayama, K., Watanabe, S., Takafuji, T., Tsuji, T., Hironaka, K., Matsumoto, M., Nakayama, K. I., Enari, M., Kohno, T., Shiraishi, K., Kiyono, T., Yoshida, K., Sugimoto, N. & Fujita, M., Jan 1 2017, In : EMBO Reports. 18, 1, p. 123-137 15 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)