Department of Molecular and Cellular Biology

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Zoledronic Acid Enhances Lipopolysaccharide-Stimulated Proinflammatory Reactions through Controlled Expression of SOCS1 in Macrophages

Muratsu, D., Yoshiga, D., Taketomi, T., Onimura, T., Seki, Y., Matsumoto, A. & Nakamura, S., Jul 9 2013, In : PloS one. 8, 7, e67906.

Research output: Contribution to journalArticle

27 Citations (Scopus)

ZFP36L1 and ZFP36L2 control LDLR mRNA stability via the ERK-RSK pathway

Adachi, S., Homoto, M., Tanaka, R., Hioki, Y., Murakami, H., Suga, H., Matsumoto, M., Nakayama, K. I., Hatta, T., Iemura, S. I. & Natsume, T., Jan 1 2014, In : Nucleic acids research. 42, 15, p. 10037-10049 13 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Zfp281 Shapes the Transcriptome of Trophoblast Stem Cells and Is Essential for Placental Development

Ishiuchi, T., Ohishi, H., Sato, T., Kamimura, S., Yorino, M., Abe, S., Suzuki, A., Wakayama, T., Suyama, M. & Sasaki, H., May 7 2019, In : Cell Reports. 27, 6, p. 1742-1754.e6

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)

VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases

Kamura, T., Maenaka, K., Kotoshiba, S., Matsumoto, M., Kohda, D., Conaway, R. C., Conaway, J. W. & Nakayama, K. I., Dec 15 2004, In : Genes and Development. 18, 24, p. 3055-3065 11 p.

Research output: Contribution to journalArticle

316 Citations (Scopus)

UV damage-induced phosphorylation of HBO1 triggers CRL4DDB2-mediated degradation to regulate cell proliferation

Matsunuma, R., Niida, H., Ohhata, T., Kitagawa, K., Sakai, S., Uchida, C., Shiotani, B., Matsumoto, M., Nakayama, K. I., Ogura, H., Shiiya, N. & Kitagawa, M., Jan 1 2016, In : Molecular and cellular biology. 36, 3, p. 394-406 13 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Up-regulation of GPR48 induced by down-regulation of p27Kip1 enhances carcinoma cell invasiveness and metastasis

Gao, Y., Kitagawa, K., Hiramatsu, Y., Kikuchi, H., Isobe, T., Shimada, M., Uchida, C., Hattori, T., Oda, T., Nakayama, K., Nakayama, K. I., Tanaka, T., Konno, H. & Kitagawa, M., Dec 15 2006, In : Cancer Research. 66, 24, p. 11623-11631 9 p.

Research output: Contribution to journalArticle

59 Citations (Scopus)

U Box Proteins as a New Family of Ubiquitin-Protein Ligases

Hatakeyama, S., Yada, M., Matsumoto, M., Ishida, N. & Nakayama, K. I., Aug 31 2001, In : Journal of Biological Chemistry. 276, 35, p. 33111-33120 10 p.

Research output: Contribution to journalArticle

430 Citations (Scopus)

Ubiquitylation of RAG-2 by Skp2-SCF links destruction of the V(D)J recombinase to the cell cycle

Jiang, H., Chang, F. C., Ross, A. E., Lee, J., Nakayama, K., Nakayama, K. & Desiderio, S., Jun 10 2005, In : Molecular Cell. 18, 6, p. 699-709 11 p.

Research output: Contribution to journalArticle

91 Citations (Scopus)

Ubiquitylation and degradation of serum-inducible kinase by hVPS18, a RING-H2 type ubiquitin ligase

Yogosawa, S., Hatakeyama, S., Nakayama, K., Miyoshi, H., Kohsaka, S. & Akazawa, C., Dec 16 2005, In : Journal of Biological Chemistry. 280, 50, p. 41619-41627 9 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Ubiquitin-dependent proteolysis by SCF complex

Nakayama, K. & Nakayama, K. I., Dec 1 2000, In : Seikagaku. 72, 2, p. 113-117 5 p.

Research output: Contribution to journalArticle

Ubiquitin-dependent degradation of IκBα is mediated by a ubiquitin ligase Skp1/Cul 1/F-box protein FWD1

Hatakeyama, S., Kitagawa, M., Nakayama, K., Shirane, M., Matsumoto, M., Hattori, K., Higashi, H., Nakano, H., Okumura, K., Onoé, K., Good, R. A. & Nakayama, K. I., Mar 30 1999, In : Proceedings of the National Academy of Sciences of the United States of America. 96, 7, p. 3859-3863 5 p.

Research output: Contribution to journalArticle

168 Citations (Scopus)

UBE4B promotes Hdm2-mediated degradation of the tumor suppressor p53

Wu, H., Pomeroy, S. L., Ferreira, M., Teider, N., Mariani, J., Nakayama, K. I., Hatakeyama, S., Tron, V. A., Saltibus, L. F., Spyracopoulos, L. & Leng, R. P., Mar 1 2011, In : Nature medicine. 17, 3, p. 347-355 9 p.

Research output: Contribution to journalArticle

64 Citations (Scopus)

Tyrosine kinase 2 plays critical roles in the pathogenic CD4 T cell responses for the development of experimental autoimmune encephalomyelitis

Oyamada, A., Ikebe, H., Itsumi, M., Saiwai, H., Okada, S., Shimoda, K., Iwakura, Y., Nakayama, K. I., Iwamoto, Y., Yoshikai, Y. & Yamada, H., Dec 1 2009, In : Journal of Immunology. 183, 11, p. 7539-7546 8 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

Tyk2-signaling plays an important role in host defense against Escherichia coli through IL-23-induced IL-17 production by γδ T cells

Nakamura, R., Shibata, K., Yamada, H., Shimoda, K., Nakayama, K. & Yoshikai, Y., Aug 1 2008, In : Journal of Immunology. 181, 3, p. 2071-2075 5 p.

Research output: Contribution to journalArticle

49 Citations (Scopus)

Tyk2 signaling in host environment plays an important role in contraction of antigen-specific CD8+ T cells following a microbial infection

Li, W., Yamada, H., Yajima, T., Nakagawa, R., Shimoda, K., Nakayama, K. & Yoshikai, Y., Apr 1 2007, In : Journal of Immunology. 178, 7, p. 4482-4488 7 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Tyk2 plays a restricted role in IFNα signaling, although it is required for IL-12-mediated T cell function

Shimoda, K., Kato, K., Aoki, K., Matsuda, T., Miyamoto, A., Shibamori, M., Yamashita, M., Numata, A., Takase, K., Kobayashi, S., Shibata, S., Asano, Y., Gondo, H., Sekiguchi, K., Nakayama, K., Nakayama, T., Okamura, T., Okamura, S., Niho, Y. & Nakayama, K. I., Jan 1 2000, In : Immunity. 13, 4, p. 561-571 11 p.

Research output: Contribution to journalArticle

239 Citations (Scopus)

Tyk2 is essential for IFN-α-induced gene expression in mast cells

Mori, Y., Hirose, K., Suzuki, K., Nakajima, H., Seto, Y., Ikeda, K., Shimoda, K., Nakayama, K. I., Saito, Y. & Iwamoto, I., Jun 15 2004, In : International Archives of Allergy and Immunology. 134, SUPPL. 1, p. 25-29 5 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Tyk2-dependent bystander activation of conventional and nonconventional Th1 cell subsets contributes to innate host defense against listeria monocytogenes infection

Hashiguchi, T., Oyamada, A., Sakuraba, K., Shimoda, K., Nakayama, K. I., Iwamoto, Y., Yoshikai, Y. & Yamada, H., May 15 2014, In : Journal of Immunology. 192, 10, p. 4739-4747 9 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Two inhibitory systems and CKIs regulate cell cycle exit of mammalian cardiomyocytes after birth

Tane, S., Okayama, H., Ikenishi, A., Amemiya, Y., Nakayama, K. & Takeuchi, T., Oct 16 2015, In : Biochemical and Biophysical Research Communications. 466, 2, p. 147-154 8 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis

Nishitani, H., Sugimoto, N., Roukos, V., Nakanishi, Y., Saijo, M., Obuse, C., Tsurimoto, T., Nakayama, K. I., Nakayama, K., Fujita, M., Lygerou, Z. & Nishimoto, T., Mar 8 2006, In : EMBO Journal. 25, 5, p. 1126-1136 11 p.

Research output: Contribution to journalArticle

280 Citations (Scopus)

Truncation mutants of ASXL1 observed in myeloid malignancies are expressed at detectable protein levels

Inoue, D., Matsumoto, M., Nagase, R., Saika, M., Fujino, T., Nakayama, K. I. & Kitamura, T., Mar 1 2016, In : Experimental Hematology. 44, 3, p. 172-176.e1

Research output: Contribution to journalArticle

24 Citations (Scopus)

TRIM8 regulates Nanog via Hsp90β-mediated nuclear translocation of STAT3 in embryonic stem cells

Okumura, F., Okumura, A. J., Matsumoto, M., Nakayama, K. I. & Hatakeyama, S., Oct 1 2011, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1813, 10, p. 1784-1792 9 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

TRIM8 modulates STAT3 activity through negative regulation of PIAS3

Okumura, F., Matsunaga, Y., Katayama, Y., Nakayama, K. I. & Hatakeyama, S., Jul 1 2010, In : Journal of Cell Science. 123, 13, p. 2238-2245 8 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)

Trans-omic Analysis Reveals Selective Responses to Induced and Basal Insulin across Signaling, Transcriptional, and Metabolic Networks

Kawata, K., Hatano, A., Yugi, K., Sano, T., Fujii, M., Tomizawa, Y., Kokaji, T., Tanaka, K. Y., Uda, S., Suzuki, Y., Matsumoto, M., Nakayama, K., Saitoh, K., Kato, K., Ueno, A., Ohishi, M., Hirayama, A., Soga, T. & Kuroda, S., 2018, In : iScience. 7, p. 212-229

Research output: Contribution to journalArticle

Trans-omic Analysis Reveals Selective Responses to Induced and Basal Insulin across Signaling, Transcriptional, and Metabolic Networks

Kawata, K., Hatano, A., Yugi, K., Kubota, H., Sano, T., Fujii, M., Tomizawa, Y., Kokaji, T., Tanaka, K. Y., Uda, S., Suzuki, Y., Matsumoto, M., Nakayama, K. I., Saitoh, K., Kato, K., Ueno, A., Ohishi, M., Hirayama, A., Soga, T. & Kuroda, S., Sep 28 2018, In : iScience. 7, p. 212-229 18 p.

Research output: Contribution to journalArticle

Open Access
7 Citations (Scopus)

Transcription factors interfering with dedifferentiation induce cell type-specific transcriptional profiles

Hikichi, T., Matoba, R., Ikeda, T., Watanabe, A., Yamamoto, T., Yoshitake, S., Tamura-Nakano, M., Kimura, T., Kamon, M., Shimura, M., Kawakami, K., Okuda, A., Okochi, H., Inoue, T., Suzuki, A. & Masui, S., Apr 16 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 16, p. 6412-6417 6 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Transcription Factor PU.1 Represses and Activates Gene Expression in Early T Cells by Redirecting Partner Transcription Factor Binding

Hosokawa, H., Ungerbäck, J., Wang, X., Matsumoto, M., Nakayama, K. I., Cohen, S. M., Tanaka, T. & Rothenberg, E. V., Jun 19 2018, In : Immunity. 48, 6, p. 1119-1134.e7

Research output: Contribution to journalArticle

21 Citations (Scopus)

Transcriptional up-regulation of MMP12 and MMP13 by asbestos occurs via a PKCδ-dependent pathway in murine lung

Shukla, A., Barrett, T. F., Nakayama, K., Nakayama, K., Mossman, B. T. & Lounsbury, K. M., May 2006, In : FASEB Journal. 20, 7

Research output: Contribution to journalArticle

34 Citations (Scopus)

TMEM55B contributes to lysosomal homeostasis and amino acid–induced mTORC1 activation

Hashimoto, Y., Shirane, M. & Nakayama, K. I., Jun 2018, In : Genes to Cells. 23, 6, p. 418-434 17 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Tissue-specific expression of histone H3 variants diversified after species separation

Maehara, K., Harada, A., Sato, Y., Matsumoto, M., Nakayama, K. I., Kimura, H. & Ohkawa, Y., Sep 17 2015, In : Epigenetics and Chromatin. 8, 1, 35.

Research output: Contribution to journalArticle

20 Citations (Scopus)

The SOCS Box of SOCS-1 Accelerates Ubiquitin-dependent Proteolysis of TEL-JAK2

Kamizono, S., Hanada, T., Yasukawa, H., Minoguchi, S., Kato, R., Minoguchi, M., Hattori, K., Hatakeyama, S., Yada, M., Morita, S., Kitamura, T., Kato, H., Nakayama, K. I. & Yoshimura, A., Apr 20 2001, In : Journal of Biological Chemistry. 276, 16, p. 12530-12538 9 p.

Research output: Contribution to journalArticle

249 Citations (Scopus)

The Skp2-SCF E3 ligase regulates akt ubiquitination, glycolysis, herceptin sensitivity, and tumorigenesis

Chan, C. H., Li, C. F., Yang, W. L., Gao, Y., Lee, S. W., Feng, Z., Huang, H. Y., Tsai, K. K. C., Flores, L. G., Shao, Y., Hazle, J. D., Yu, D., Wei, W., Sarbassov, D., Hung, M. C., Nakayama, K. I. & Lin, H. K., May 25 2012, In : Cell. 149, 5, p. 1098-1111 14 p.

Research output: Contribution to journalArticle

207 Citations (Scopus)

The SKP2 E3 ligase regulates basal homeostasis and stress-induced regeneration of HSCs

Rodriguez, S., Wang, L., Mumaw, C., Srour, E. F., Lo Celso, C., Nakayama, K. I. & Carlesso, N., Jun 16 2011, In : Blood. 117, 24, p. 6509-6519 11 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

The second phase activation of protein kinase C δ at late G1 is required for DNA synthesis in serum-induced cell cycle progression

Kitamura, K., Mizuno, K., Etoh, A., Akita, Y., Miyamoto, A., Nakayama, K. & Ohno, S., Apr 1 2003, In : Genes to Cells. 8, 4, p. 311-324 14 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

The SCFβ-TRCP E3 ubiquitin ligase complex targets Lipin1 for ubiquitination and degradation to promote hepatic lipogenesis

Shimizu, K., Fukushima, H., Ogura, K., Lien, E. C., Nihira, N. T., Zhang, J., North, B. J., Guo, A., Nagashima, K., Nakagawa, T., Hoshikawa, S., Watahiki, A., Okabe, K., Yamada, A., Toker, A., Asara, J. M., Fukumoto, S., Nakayama, K. I., Nakayama, K., Inuzuka, H. & 1 others, Wei, W., Jan 3 2017, In : Science Signaling. 10, 460

Research output: Contribution to journalArticle

17 Citations (Scopus)

The role of β-TrCP1 and β-TrCP2 in circadian rhythm generation by mediating degradation of clock protein PER2

Ohsaki, K., Oishi, K., Kozono, Y., Nakayama, K., Nakayama, K. & Ishida, N., Nov 1 2008, In : Journal of biochemistry. 144, 5, p. 609-618 10 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)

The role of Mediator and Little Elongation Complex in transcription termination

Takahashi, H., Ranjan, A., Chen, S., Suzuki, H., Shibata, M., Hirose, T., Hirose, H., Sasaki, K., Abe, R., Chen, K., He, Y., Zhang, Y., Takigawa, I., Tsukiyama, T., Watanabe, M., Fujii, S., Iida, M., Yamamoto, J., Yamaguchi, Y., Suzuki, Y. & 10 others, Matsumoto, M., Nakayama, K. I., Washburn, M. P., Saraf, A., Florens, L., Sato, S., Tomomori-Sato, C., Conaway, R. C., Conaway, J. W. & Hatakeyama, S., Dec 1 2020, In : Nature communications. 11, 1, 1063.

Research output: Contribution to journalArticle

Open Access

The pericentromeric protein shugoshin 2 cooperates with HSF1 in heat shock response and RNA Pol II recruitment

Takii, R., Fujimoto, M., Matsumoto, M., Srivastava, P., Katiyar, A., Nakayama, K. I. & Nakai, A., Dec 16 2019, In : EMBO Journal. 38, 24, e102566.

Research output: Contribution to journalArticle

1 Citation (Scopus)

The pathophysiologic role of the protein kinase Cδ pathway in the intervertebral discs of rabbits and mice: In vitro, ex vivo, and in vivo studies

Ellman, M. B., Kim, J. S., An, H. S., Kroin, J. S., Li, X., Chen, D., Yan, D., Buechter, D. D., Nakayama, K., Liu, B., Morgan, S. & Im, H. J., Jun 1 2012, In : Arthritis and rheumatism. 64, 6, p. 1950-1959 10 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

The Papillomavirus E7 Oncoprotein Is Ubiquitinated by UbcH7 and Cullin 1- and Skp2-Containing E3 Ligase

Oh, K. J., Kalinina, A., Wang, J., Nakayama, K., Nakayama, K. I. & Bagchi, S., May 1 2004, In : Journal of virology. 78, 10, p. 5338-5346 9 p.

Research output: Contribution to journalArticle

60 Citations (Scopus)

The novel heart-specific RING finger protein 207 is involved in energy metabolism in cardiomyocytes

Mizushima, W., Takahashi, H., Watanabe, M., Kinugawa, S., Matsushima, S., Takada, S., Yokota, T., Furihata, T., Matsumoto, J., Tsuda, M., Chiba, I., Nagashima, S., Yanagi, S., Matsumoto, M., Nakayama, K. I., Tsutsui, H. & Hatakeyama, S., Nov 1 2016, In : Journal of Molecular and Cellular Cardiology. 100, p. 43-53 11 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

The ISG15 isopeptidase UBP43 is regulated by proteolysis via the SCF Skp2 ubiquitin ligase

Tokarz, S., Berset, C., La Rue, J., Friedman, K., Nakayama, K. I., Nakayama, K., Zhang, D. E. & Lanker, S., Nov 5 2004, In : Journal of Biological Chemistry. 279, 45, p. 46424-46430 7 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

The FBXL5-IRP2 axis is integral to control of iron metabolism in vivo

Moroishi, T., Nishiyama, M., Takeda, Y., Iwai, K. & Nakayama, K. I., Sep 7 2011, In : Cell metabolism. 14, 3, p. 339-351 13 p.

Research output: Contribution to journalArticle

77 Citations (Scopus)

The F box protein S phase kinase-associated protein 2 regulates adipose mass and adipocyte number in vivo

Cooke, P. S., Holsberger, D. R., Cimafranca, M. A., Meling, D. D., Beals, C. M., Nakayama, K., Nakayama, K. I. & Kiyokawa, H., Jun 1 2007, In : Obesity. 15, 6, p. 1400-1408 9 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

The F-box protein Skp2 participates in c-Myc proteosomal degradation and acts as a cofactor for c-Myc-regulated transcription

Von Der Lehr, N., Johansson, S., Wu, S., Bahram, F., Castell, A., Cetinkaya, C., Hydbring, P., Weidung, I., Nakayama, K., Nakayama, K. I., Söderberg, O., Kerppola, T. K. & Larsson, L. G., May 1 2003, In : Molecular Cell. 11, 5, p. 1189-1200 12 p.

Research output: Contribution to journalArticle

363 Citations (Scopus)

The cyclin-dependent kinase inhibitors p57 and p27 regulate neuronal migration in the developing mouse neocortex

Itoh, Y., Masuyama, N., Nakayama, K., Nakayama, K. I. & Gotoh, Y., Jan 5 2007, In : Journal of Biological Chemistry. 282, 1, p. 390-396 7 p.

Research output: Contribution to journalArticle

71 Citations (Scopus)

The Autism-Related Protein SETD5 Controls Neural Cell Proliferation through Epigenetic Regulation of rDNA Expression

Nakagawa, T., Hattori, S., Nobuta, R., Kimura, R., Nakagawa, M., Matsumoto, M., Nagasawa, Y., Funayama, R., Miyakawa, T., Inada, T., Osumi, N., Nakayama, K. I. & Nakayama, K., Apr 24 2020, In : iScience. 23, 4, 101030.

Research output: Contribution to journalArticle

Open Access

The Autism-Related Protein CHD8 Cooperates with C/EBPβ to Regulate Adipogenesis

Kita, Y., Katayama, Y., Shiraishi, T., Oka, T., Sato, T., Suyama, M., Ohkawa, Y., Miyata, K., Oike, Y., Shirane, M., Nishiyama, M. & Nakayama, K. I., May 15 2018, In : Cell Reports. 23, 7, p. 1988-2000 13 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

The amelioration of renal damage in Skp2-deficient mice canceled by p27Kip1 deficiency in Skp2-/- p27-/- mice

Suzuki, S., Fukasawa, H., Misaki, T., Togawa, A., Ohashi, N., Kitagawa, K., Kotake, Y., Liu, N., Niida, H., Nakayama, K., Nakayama, K. I., Yamamoto, T. & Kitagawa, M., Apr 27 2012, In : PloS one. 7, 4, e36249.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Tbx3 controls the fate of hepatic progenitor cells in liver development by suppressing p19ARF expression

Suzuki, A., Sekiya, S., Büscher, D., Belmonte, J. C. I. & Taniguchi, H., May 1 2008, In : Development. 135, 9, p. 1589-1595 7 p.

Research output: Contribution to journalArticle

85 Citations (Scopus)