Department of Molecular and Cellular Biology

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2011

Fbxw7-dependent degradation of notch is required for control of "Stemness" and neuronal-glial differentiation in neural stem cells

Matsumoto, A., Onoyama, I., Sunabori, T., Kageyama, R., Okano, H. & Nakayama, K. I., Apr 15 2011, In : Journal of Biological Chemistry. 286, 15, p. 13754-13764 11 p.

Research output: Contribution to journalArticle

63 Citations (Scopus)

Fbxw7 regulates lipid metabolism and cell fate decisions in the mouse liver

Onoyama, I., Suzuki, A., Matsumoto, A., Tomita, K., Katagiri, H., Oike, Y., Nakayama, K. & Nakayama, K. I., Jan 4 2011, In : Journal of Clinical Investigation. 121, 1, p. 342-354 13 p.

Research output: Contribution to journalArticle

76 Citations (Scopus)

Fbxw7β resides in the endoplasmic reticulum membrane and protects cells from oxidative stress

Matsumoto, A., Tateishi, Y., Onoyama, I., Okita, Y., Nakayama, K. & Nakayama, K., Apr 1 2011, In : Cancer Science. 102, 4, p. 749-755 7 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Four mood stabilizers commonly induce FEZ1 expression in human astrocytes

Yu, Z., Ono, C., Kim, H. B., Komatsu, H., Tanabe, Y., Sakae, N., Nakayama, K., Matsuoka, H., Sora, I., Bunney, W. E. & Tomita, H., Aug 1 2011, In : Bipolar Disorders. 13, 5-6, p. 486-499 14 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Functional analyses of the activation loop of phototropin2 in Arabidopsis

Inoue, S. I., Matsushita, T., Tomokiyo, Y., Matsumoto, M., Nakayama, K. I., Kinoshita, T. & Shimazaki, K. I., May 1 2011, In : Plant physiology. 156, 1, p. 117-128 12 p.

Research output: Contribution to journalArticle

52 Citations (Scopus)
23 Citations (Scopus)

Impaired ovarian development and reduced fertility in female mice deficient in Skp2

Fotovati, A., Abu-Ali, S., Nakayama, K. & Nakayama, K. I., Jun 1 2011, In : Journal of Anatomy. 218, 6, p. 668-677 10 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

miR-221 and miR-155 regulate human dendritic cell development, apoptosis, and IL-12 production through targeting of p27 kip1, KPC1, and SOCS-1

Lu, C., Huang, X., Zhang, X., Roensch, K., Cao, Q., Nakayama, K. I., Blazar, B. R., Zeng, Y. & Zhou, X., Apr 21 2011, In : Blood. 117, 16, p. 4293-4303 11 p.

Research output: Contribution to journalArticle

193 Citations (Scopus)

P57 Is required for quiescence and maintenance of adult hematopoietic stem cells

Matsumoto, A., Takeishi, S., Kanie, T., Susaki, E., Onoyama, I., Tateishi, Y., Nakayama, K. & Nakayama, K. I., Sep 2 2011, In : Cell stem cell. 9, 3, p. 262-271 10 p.

Research output: Contribution to journalArticle

165 Citations (Scopus)

P57 Kip2 and p27 Kip1 cooperate to maintain hematopoietic stem cell quiescence through interactions with Hsc70

Zou, P., Yoshihara, H., Hosokawa, K., Tai, I., Shinmyozu, K., Tsukahara, F., Maru, Y., Nakayama, K., Nakayama, K. I. & Suda, T., Sep 2 2011, In : Cell stem cell. 9, 3, p. 247-261 15 p.

Research output: Contribution to journalArticle

165 Citations (Scopus)

PKCδ inhibition enhances tyrosine hydroxylase phosphorylation in mice after methamphetamine treatment

Shin, E. J., Duong, C. X., Nguyen, X. K. T., Bing, G., Bach, J. H., Park, D. H., Nakayama, K., Ali, S. F., Kanthasamy, A. G., Cadet, J. L., Nabeshima, T. & Kim, H. C., Aug 1 2011, In : Neurochemistry International. 59, 1, p. 39-50 12 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Plasma gelsolin facilitates interaction between β2 glycoprotein I and α5β1 integrin

Bohgaki, M., Matsumoto, M., Atsumi, T., Kondo, T., Yasuda, S., Horita, T., Nakayama, K. I., Okumura, F., Hatakeyama, S. & Koike, T., Jan 1 2011, In : Journal of Cellular and Molecular Medicine. 15, 1, p. 141-151 11 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Proteome of ubiquitin/MVB pathway: Possible involvement of iron-induced ubiquitylation of transferrin receptor in lysosomal degradation

Tachiyama, R., Ishikawa, D., Matsumoto, M., Nakayama, K. I., Yoshimori, T., Yokota, S., Himeno, M., Tanaka, Y. & Fujita, H., Apr 1 2011, In : Genes to Cells. 16, 4, p. 448-466 19 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)
50 Citations (Scopus)

SCFFBW7 regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction

Inuzuka, H., Shaik, S., Onoyama, I., Gao, D., Tseng, A., Maser, R. S., Zhai, B., Wan, L., Gutierrez, A., Lau, A. W., Xiao, Y., Christie, A. L., Aster, J., Settleman, J., Gygi, S. P., Kung, A. L., Look, T., Nakayama, K. I., Depinho, R. A. & Wei, W., Mar 3 2011, In : Nature. 471, 7336, p. 104-109 6 p.

Research output: Contribution to journalArticle

382 Citations (Scopus)

Skp2 is necessary for Myc-induced keratinocyte proliferation but dispensable for Myc oncogenic activity in the oral epithelium

Sistrunk, C., MacIas, E., Nakayama, K., Kim, Y. & Rodriguez-Puebla, M. L., Jun 2011, In : American Journal of Pathology. 178, 6, p. 2470-2477 8 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

The FBXL5-IRP2 axis is integral to control of iron metabolism in vivo

Moroishi, T., Nishiyama, M., Takeda, Y., Iwai, K. & Nakayama, K. I., Sep 7 2011, In : Cell metabolism. 14, 3, p. 339-351 13 p.

Research output: Contribution to journalArticle

73 Citations (Scopus)

The SKP2 E3 ligase regulates basal homeostasis and stress-induced regeneration of HSCs

Rodriguez, S., Wang, L., Mumaw, C., Srour, E. F., Lo Celso, C., Nakayama, K. I. & Carlesso, N., Jun 16 2011, In : Blood. 117, 24, p. 6509-6519 11 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

TRIM8 regulates Nanog via Hsp90β-mediated nuclear translocation of STAT3 in embryonic stem cells

Okumura, F., Okumura, A. J., Matsumoto, M., Nakayama, K. I. & Hatakeyama, S., Oct 1 2011, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1813, 10, p. 1784-1792 9 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

UBE4B promotes Hdm2-mediated degradation of the tumor suppressor p53

Wu, H., Pomeroy, S. L., Ferreira, M., Teider, N., Mariani, J., Nakayama, K. I., Hatakeyama, S., Tron, V. A., Saltibus, L. F., Spyracopoulos, L. & Leng, R. P., Mar 1 2011, In : Nature medicine. 17, 3, p. 347-355 9 p.

Research output: Contribution to journalArticle

64 Citations (Scopus)
2010

Aldehyde dehydrogenase 2 knockout accentuates ethanol-induced cardiac depression: Role of protein phosphatases

Ma, H., Yu, L., Byra, E. A., Hu, N., Kitagawa, K., Nakayama, K. I., Kawamoto, T. & Ren, J., Aug 1 2010, In : Journal of Molecular and Cellular Cardiology. 49, 2, p. 322-329 8 p.

Research output: Contribution to journalArticle

55 Citations (Scopus)

An animal model manifesting neurodegeneration and obesity

Susaki, E. & Nakayama, K. I., Jul 2010, In : Aging. 2, 7, p. 453-456 4 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Comparative analysis of human Src-family kinase substrate specificity in vitro

Takeda, H., Kawamura, Y., Miura, A., Mori, M., Wakamatsu, A., Yamamoto, J. I., Isogai, T., Matsumoto, M., Nakayama, K., Natsume, T., Nomura, N. & Goshima, N., Nov 5 2010, In : Journal of Proteome Research. 9, 11, p. 5982-5993 12 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Complex regulation of cell-cycle inhibitors by Fbxw7 in mouse embryonic fibroblasts

Masuda, K., Ishikawa, Y., Onoyama, I., Unno, M., De Alborán, I. M., Nakayama, K. I. & Nakayama, K., Mar 1 2010, In : Oncogene. 29, 12, p. 1798-1809 12 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Deciphering the transcriptional complex critical for RhoA gene expression and cancer metastasis

Chan, C. H., Lee, S. W., Li, C. F., Wang, J., Yang, W. L., Wu, C. Y., Wu, J., Nakayama, K. I., Kang, H. Y., Huang, H. Y., Hung, M. C., Pandolfi, P. P. & Lin, H. K., May 1 2010, In : Nature Cell Biology. 12, 5, p. 457-467 11 p.

Research output: Contribution to journalArticle

143 Citations (Scopus)

EGF signaling activates proliferation and blocks apoptosis of mouse and human intestinal stem/progenitor cells in long-term monolayer cell culture

Suzuki, A., Sekiya, S., Gunshima, E., Fujii, S. & Taniguchi, H., Oct 1 2010, In : Laboratory Investigation. 90, 10, p. 1425-1436 12 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

Fbxo45, a novel ubiquitin ligase, regulates synaptic activity

Tada, H., Okano, H. J., Takagi, H., Shibata, S., Yao, I., Matsumoto, M., Saiga, T., Nakayama, K. I., Kashima, H., Takahashi, T., Setou, M. & Okano, H., Feb 5 2010, In : Journal of Biological Chemistry. 285, 6, p. 3840-3849 10 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)

GABAA receptor subunit alteration-dependent diazepam insensitivity in the cerebellum of phospholipase C-related inactive protein knockout mice

Mizokami, A., Tanaka, H., Ishibashi, H., Umebayashi, H., Fukami, K., Takenawa, T., Nakayama, K. I., Yokoyama, T., Nabekura, J., Kanematsu, T. & Hirata, M., Jul 1 2010, In : Journal of Neurochemistry. 114, 1, p. 302-310 9 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Human proteins that specifically bind to 8-oxoguanine-containing RNA and their responses to oxidative stress

Hayakawa, H., Fujikane, A., Ito, R., Matsumoto, M., Nakayama, K. & Sekiguchi, M., Dec 10 2010, In : Biochemical and Biophysical Research Communications. 403, 2, p. 220-224 5 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Increased E4 activity in mice leads to ubiquitin-containing aggregates and degeneration of hypothalamic neurons resulting in obesity

Susaki, E., Kaneko-Oshikawa, C., Miyata, K., Tabata, M., Yamada, T., Oike, Y., Katagiri, H. & Nakayama, K. I., May 14 2010, In : Journal of Biological Chemistry. 285, 20, p. 15538-15547 10 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

In vitro histone demethylase assay

Tsukada, Y. I. & Nakayama, K. I., Oct 1 2010, In : Cold Spring Harbor Protocols. 5, 10

Research output: Contribution to journalArticle

6 Citations (Scopus)

KDM7 is a dual demethylase for histone H3 Lys 9 and Lys 27 and functions in brain development

Tsukada, Y. I., Ishitani, T. & Nakayama, K. I., Mar 1 2010, In : Genes and Development. 24, 5, p. 432-437 6 p.

Research output: Contribution to journalArticle

90 Citations (Scopus)

Loss of FBXW7, a cell cycle regulating gene, in colorectal cancer: Clinical significance

Iwatsuki, M., Mimori, K., Lshii, H., Yokobori, T., Takatsuno, Y., Sato, T., Toh, H., Onoyama, I., Nakayama, K. I., Baba, H. & Mori, M., Apr 15 2010, In : International Journal of Cancer. 126, 8, p. 1828-1837 10 p.

Research output: Contribution to journalArticle

96 Citations (Scopus)

Loss of protein kinase C delta alters mammary gland development and apoptosis

Allen-Petersen, B. L., Miller, M. R., Neville, M. C., Anderson, S. M., Nakayama, K. I. & Reyland, M. E., Jan 1 2010, In : Cell Death and Disease. 1, 1, e17.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Molecular basis for the association of human E4B U box ubiquitin ligase with E2-conjugating enzymes UbcH5c and Ubc4

Benirschke, R. C., Thompson, J. R., Nominé, Y., Wasielewski, E., Juranić, N., Macura, S., Hatakeyama, S., Nakayama, K. I., Botuyan, M. V. & Mer, G., Aug 1 2010, In : Structure. 18, 8, p. 955-965 11 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)
11 Citations (Scopus)

p27 modulates tropism of mesenchymal stem cells toward brain tumors

Gao, Y., Gu, C., Li, S., Tokuyama, T., Yokota, N., Nakayama, K. I., Kitagawa, M. & Namba, H., Jul 1 2010, In : Experimental and Therapeutic Medicine. 1, 4, p. 695-699 5 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Phospholipase C-related but catalytically inactive protein is required for insulin-induced cell surface expression of γ-aminobutyric acid type A receptors

Fujii, M., Kanematsu, T., Ishibashi, H., Fukami, K., Takenawa, T., Nakayama, K. I., Moss, S. J., Nabekura, J. & Hirata, M., Feb 12 2010, In : Journal of Biological Chemistry. 285, 7, p. 4837-4846 10 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

Phosphorylation of the chromodomain changes the binding specificity of Cbx2 for methylated histone H3

Hatano, A., Matsumoto, M., Higashinakagawa, T. & Nakayama, K. I., Jun 18 2010, In : Biochemical and Biophysical Research Communications. 397, 1, p. 93-99 7 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Skp2 directs Myc-mediated suppression of p27Kip1 yet has modest effects on Myc-driven lymphomagenesis

Old, J. B., Kratzat, S., Hoellein, A., Graf, S., Nilsson, J. A., Nilsson, L., Nakayama, K. I., Peschel, C., Cleveland, J. L. & Keller, U. B., Mar 1 2010, In : Molecular Cancer Research. 8, 3, p. 353-362 10 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Skp2 is required for survival of aberrantly proliferating Rb1-deficient cells and for tumorigenesis in Rb1+/ mice

Wang, H., Bauzon, F., Ji, P., Xu, X., Sun, D., Locker, J., Sellers, R. S., Nakayama, K., Nakayama, K. I., Cobrinik, D. & Zhu, L., Jan 1 2010, In : Nature genetics. 42, 1, p. 83-88 6 p.

Research output: Contribution to journalArticle

74 Citations (Scopus)

Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence

Lin, H. K., Chen, Z., Wang, G., Nardella, C., Lee, S. W., Chan, C. H., Yang, W. L., Wang, J., Egia, A., Nakayama, K. I., Cordon-Cardo, C., Teruya-Feldstein, J. & Pandolfi, P. P., Mar 18 2010, In : Nature. 464, 7287, p. 374-379 6 p.

Research output: Contribution to journalArticle

284 Citations (Scopus)

TRIM8 modulates STAT3 activity through negative regulation of PIAS3

Okumura, F., Matsunaga, Y., Katayama, Y., Nakayama, K. I. & Hatakeyama, S., Jul 1 2010, In : Journal of Cell Science. 123, 13, p. 2238-2245 8 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)

What determines the specificity and outcomes of Ubiquitin signaling?

Ikeda, F., Crosetto, N. & Dikic, I., Nov 24 2010, In : Cell. 143, 5, p. 677-681 5 p.

Research output: Contribution to journalArticle

Open Access
107 Citations (Scopus)
2009

CDK inhibitors selectively diminish cell cycle controlled activation of the histone H4 gene promoter by p220NPAT and HiNF-P

Mitra, P., Ghule, P. N., Van Der Deen, M., Medina, R., Xie, R. L., Holmes, W. F., Ye, X., Nakayama, K., Harper, J. W., Stein, J. L., Stein, G. S. & Van Wijnen, A. J., May 1 2009, In : Journal of cellular physiology. 219, 2, p. 438-448 11 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

CHD8 suppresses p53-mediated apoptosis through histone H1 recruitment during early embryogenesis

Nishiyama, M., Oshikawa, K., Tsukada, Y. I., Nakagawa, T., Iemura, S. I., Natsume, T., Fan, Y., Kikuchi, A., Skoultchi, A. I. & Nakayama, K. I., Jan 19 2009, In : Nature Cell Biology. 11, 2, p. 172-182 11 p.

Research output: Contribution to journalArticle

94 Citations (Scopus)

Cholinergic alterations following alcohol exposure in the frontal cortex of Aldh2-deficient mice models

Jamal, M., Ameno, K., Miki, T., Wang, W., Kumihashi, M., Isse, T., Kawamoto, T., Kitagawa, K., Nakayama, K., Ijiri, I. & Kinoshita, H., Oct 12 2009, In : Brain Research. 1295, p. 37-43 7 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Common and specific roles of the related CDK inhibitors p27 and p57 revealed by a knock-in mouse model

Susaki, E., Nakayama, K., Yamasaki, L. & Nakayama, K. I., Mar 31 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 13, p. 5192-5197 6 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)

Cotranslational Targeting of XBP1 Protein to the Membrane Promotes Cytoplasmic Splicing of Its Own mRNA

Yanagitani, K., Imagawa, Y., Iwawaki, T., Hosoda, A., Saito, M., Kimata, Y. & Kohno, K., Apr 24 2009, In : Molecular Cell. 34, 2, p. 191-200 10 p.

Research output: Contribution to journalArticle

Open Access
100 Citations (Scopus)

Ethanol metabolism in ALDH2 knockout mice - Blood acetate levels

Kiyoshi, A., Weihuan, W., Mostofa, J., Mitsuru, K., Toyoshi, I., Toshihiro, K., Kyoko, K., Keiichi, N., Iwao, I. & Hiroshi, K., Apr 1 2009, In : Legal Medicine. 11, SUPPL. 1, p. S413-S415

Research output: Contribution to journalArticle

15 Citations (Scopus)