Department of Molecular and Cellular Biology

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2007

Reproductive toxicity of ethylene glycol monoethyl ether in Aldh2 knockout mice

Wang, R. S., Ohtani, K., Suda, M., Kitagawa, K., Nakayama, K., Kawamoto, T. & Nakajima, T., Aug 1 2007, In : Industrial health. 45, 4, p. 574-578 5 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Skp2 controls adipocyte proliferation during the development of obesity

Sakai, T., Sakaue, H., Nakamura, T., Okada, M., Matsuki, Y., Watanabe, E., Hiramatsu, R., Nakayama, K., Nakayama, K. & Kasuga, M., Jan 19 2007, In : Journal of Biological Chemistry. 282, 3, p. 2038-2046 9 p.

Research output: Contribution to journalArticle

69 Citations (Scopus)

The cyclin-dependent kinase inhibitors p57 and p27 regulate neuronal migration in the developing mouse neocortex

Itoh, Y., Masuyama, N., Nakayama, K., Nakayama, K. I. & Gotoh, Y., Jan 5 2007, In : Journal of Biological Chemistry. 282, 1, p. 390-396 7 p.

Research output: Contribution to journalArticle

70 Citations (Scopus)

The F box protein S phase kinase-associated protein 2 regulates adipose mass and adipocyte number in vivo

Cooke, P. S., Holsberger, D. R., Cimafranca, M. A., Meling, D. D., Beals, C. M., Nakayama, K., Nakayama, K. I. & Kiyokawa, H., Jun 1 2007, In : Obesity. 15, 6, p. 1400-1408 9 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Tyk2 signaling in host environment plays an important role in contraction of antigen-specific CD8+ T cells following a microbial infection

Li, W., Yamada, H., Yajima, T., Nakagawa, R., Shimoda, K., Nakayama, K. & Yoshikai, Y., Apr 1 2007, In : Journal of Immunology. 178, 7, p. 4482-4488 7 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2006

Alteration of intra-pancreatic target-organ specificity by abrogation of Aire in NOD mice

Niki, S., Oshikawa, K., Mouri, Y., Hirota, F., Matsushima, A., Yano, M., Han, H., Bando, Y., Izumi, K., Matsumoto, M., Nakayama, K. I., Kuroda, N. & Matsumoto, M., May 1 2006, In : Journal of Clinical Investigation. 116, 5, p. 1292-1301 10 p.

Research output: Contribution to journalArticle

77 Citations (Scopus)

Cathepsin E-deficient mice show increased susceptibility to bacterial infection associated with the decreased expression of multiple cell surface Toll-like receptors

Tsukuba, T., Yamamoto, S., Yanagawa, M., Okamoto, K., Okamoto, Y., Nakayama, K. I., Kadowaki, T. & Yamamoto, K., Jul 1 2006, In : Journal of biochemistry. 140, 1, p. 57-66 10 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)

Degradation of Tob1 mediated by SCFSkp2-dependent ubiquitination

Hiramatsu, Y., Kitagawa, K., Suzuki, T., Uchida, C., Hattori, T., Kikuchi, H., Oda, T., Hatakeyama, S., Nakayama, K. I., Yamamoto, T., Konno, H. & Kitagawa, M., Sep 1 2006, In : Cancer Research. 66, 17, p. 8477-8483 7 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)

Double knockout mice show BASH and PKCδ have different epistatic relationships in B cell maturation and CD40-mediated activation

Nojima, T., Hayashi, K., Goitsuka, R., Nakayama, K., Nakayama, K. & Kitamura, D., May 15 2006, In : Immunology Letters. 105, 1, p. 48-54 7 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Expression of cdc2 and p27(KIP1) phosphorylation in mitotic cells of the human retinoblastoma

Kase, S., Yoshida, K., Ohgami, K., Shiratori, K., Suzuki, Y., Nakayama, K. I. & Ohno, S., Mar 1 2006, In : International journal of molecular medicine. 17, 3, p. 465-468 4 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
36 Citations (Scopus)

Fbxw7 contributes to tumor suppression by targeting multiple proteins for ubiquitin-dependent degradation

Fujii, Y., Yada, M., Nishiyama, M., Kamura, T., Takahashi, H., Tsunematsu, R., Susaki, E., Nakagawa, T., Matsumoto, A. & Nakayama, K. I., Aug 1 2006, In : Cancer Science. 97, 8, p. 729-736 8 p.

Research output: Contribution to journalArticle

51 Citations (Scopus)

Fbxw8 is essential for Cul1-Cul7 complex formation and for placental development

Tsunematsu, R., Nishiyama, M., Kotoshiba, S., Saiga, T., Kamura, T. & Nakayama, K. I., Aug 1 2006, In : Molecular and cellular biology. 26, 16, p. 6157-6169 13 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)

Geminin is essential for the development of preimplantation mouse embryos

Hara, K., Nakayama, K. & Nakayama, K., Nov 1 2006, In : Genes to Cells. 11, 11, p. 1281-1293 13 p.

Research output: Contribution to journalArticle

49 Citations (Scopus)

HSP27 favors ubiquitination and proteasomal degradation of p27 Kip1 and helps S-phase re-entry in stressed cells

Parcellier, A., Brunet, M., Schmitt, E., Col, E., Didelot, C., Hammann, A., Nakayama, K., Nakayama, K., Khochbin, S., Solary, E. & Garrido, C., Jun 2006, In : FASEB Journal. 20, 8

Research output: Contribution to journalArticle

90 Citations (Scopus)

Identification of novel E2F1 target genes regulated in cell cycle-dependent and independent manners

Iwanaga, R., Komori, H., Ishida, S., Okamura, N., Nakayama, K., Nakayama, K. & Ohtani, K., Mar 16 2006, In : Oncogene. 25, 12, p. 1786-1798 13 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)

Impaired germ cell development due to compromised cell cycle progression in Skp2-deficient mice

Fotovati, A., Nakayama, K. & Nakayama, K. I., Apr 7 2006, In : Cell Division. 1, 4.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Involvement of a novel Q-SNARE, D12, in quality control of the endomembrane system

Okumura, A. J., Hatsuzawa, K., Tamura, T., Nagaya, H., Saeki, K., Okumura, F., Nagao, K., Nishikawa, M., Yoshimura, A. & Wada, I., Feb 17 2006, In : Journal of Biological Chemistry. 281, 7, p. 4495-4506 12 p.

Research output: Contribution to journalArticle

Open Access
21 Citations (Scopus)

Mitogenic signalling and the p16INK4a-Rb pathway cooperate to enforce irreversible cellular senescence

Takahashi, A., Ohtani, N., Yamakoshi, K., Iida, S. I., Tahara, H., Nakayama, K., Nakayama, K. I., Ide, T., Saya, H. & Hara, E., Nov 1 2006, In : Nature Cell Biology. 8, 11, p. 1291-1297 7 p.

Research output: Contribution to journalArticle

300 Citations (Scopus)

Modulation of GABAA receptor phosphorylation and membrane trafficking by phospholipase C-related inactive protein/protein phosphatase 1 and 2A signaling complex underlying brain-derived neurotrophic factor-dependent regulation of GABAergic inhibition

Kanematsu, T., Yasunaga, A., Mizoguchi, Y., Kuratani, A., Kittler, J. T., Jovanovic, J. N., Takenaka, K., Nakayama, K. I., Fukami, K., Takenawa, T., Moss, S. J., Nabekura, J. & Hirata, M., Aug 4 2006, In : Journal of Biological Chemistry. 281, 31, p. 22180-22189 10 p.

Research output: Contribution to journalArticle

73 Citations (Scopus)

Phosphorylation of extracellular signal-regulated kinase and p27(KIP1) after retinal detachment

Kase, S., Yoshida, K., Harada, T., Harada, C., Namekata, K., Suzuki, Y., Ohgami, K., Shiratori, K., Nakayama, K. I. & Ohno, S., Mar 1 2006, In : Graefe's Archive for Clinical and Experimental Ophthalmology. 244, 3, p. 352-358 7 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Phosphorylation of p27(KIP1) in the mitotic cells of the corneal epithelium

Kase, S., Yoshida, K., Ohgami, K., Shiratori, K., Ohno, S. & Nakayama, K. I., May 1 2006, In : Current Eye Research. 31, 4, p. 307-312 6 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

PKCδ is necessary for Smad3 expression and transforming growth factor β-induced fibronectin synthesis in vascular smooth muscle cells

Ryer, E. J., Hom, R. P., Sakakibara, K., Nakayama, K., Nakayama, K., Faries, P. L., Liu, B. & Kent, K. C., Apr 1 2006, In : Arteriosclerosis, thrombosis, and vascular biology. 26, 4, p. 780-786 7 p.

Research output: Contribution to journalArticle

41 Citations (Scopus)

PKCδ regulates collagen-induced platelet aggregation through inhibition of VASP-mediated filopodia formation

Pula, G., Schuh, K., Nakayama, K., Nakayama, K. I., Walter, U. & Poole, A. W., Dec 15 2006, In : Blood. 108, 13, p. 4035-4044 10 p.

Research output: Contribution to journalArticle

79 Citations (Scopus)

Protein kinase C δ activates topoisomerase IIα to induce apoptotic cell death in response to DNA damage

Yoshida, K., Yamaguchi, T., Shinagawa, H., Taira, N., Nakayama, K. I. & Miki, Y., May 1 2006, In : Molecular and cellular biology. 26, 9, p. 3414-3431 18 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)

Protrudin induces neurite formation by directional membrane trafficking

Shirane, M. & Nakayama, K. I., Nov 3 2006, In : Science. 314, 5800, p. 818-821 4 p.

Research output: Contribution to journalArticle

127 Citations (Scopus)

Regulation of SV40 large T-antigen stability by reversible acetylation

Shimazu, T., Komatsu, Y., Nakayama, K. I., Fukazawa, H., Horinouchi, S. & Yoshida, M., Nov 30 2006, In : Oncogene. 25, 56, p. 7391-7400 10 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

Suppression of apoptosis in the protein kinase Cδ null mouse in vivo

Humphries, M. J., Limesand, K. H., Schneider, J. C., Nakayama, K. I., Anderson, S. M. & Reyland, M. E., Apr 7 2006, In : Journal of Biological Chemistry. 281, 14, p. 9728-9737 10 p.

Research output: Contribution to journalArticle

94 Citations (Scopus)

Suppression of centrosome amplification after DNA damage depends on p27 accumulation

Sugihara, E., Kanai, M., Saito, S., Nitta, T., Toyoshima, H., Nakayama, K., Nakayama, K. I., Fukasawa, K., Schwab, M., Saya, H. & Miwa, M., Apr 15 2006, In : Cancer Research. 66, 8, p. 4020-4029 10 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Transcriptional up-regulation of MMP12 and MMP13 by asbestos occurs via a PKCδ-dependent pathway in murine lung

Shukla, A., Barrett, T. F., Nakayama, K., Nakayama, K., Mossman, B. T. & Lounsbury, K. M., May 2006, In : FASEB Journal. 20, 7

Research output: Contribution to journalArticle

34 Citations (Scopus)

Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis

Nishitani, H., Sugimoto, N., Roukos, V., Nakanishi, Y., Saijo, M., Obuse, C., Tsurimoto, T., Nakayama, K. I., Nakayama, K., Fujita, M., Lygerou, Z. & Nishimoto, T., Mar 8 2006, In : EMBO Journal. 25, 5, p. 1126-1136 11 p.

Research output: Contribution to journalArticle

279 Citations (Scopus)

Up-regulation of GPR48 induced by down-regulation of p27Kip1 enhances carcinoma cell invasiveness and metastasis

Gao, Y., Kitagawa, K., Hiramatsu, Y., Kikuchi, H., Isobe, T., Shimada, M., Uchida, C., Hattori, T., Oda, T., Nakayama, K., Nakayama, K. I., Tanaka, T., Konno, H. & Kitagawa, M., Dec 15 2006, In : Cancer Research. 66, 24, p. 11623-11631 9 p.

Research output: Contribution to journalArticle

59 Citations (Scopus)
2005

A CCAAT/enhancer binding protein β isoform, liver-enriched inhibitory protein, regulates commitment of osteoblasts and adipocytes

Hata, K., Nishimura, R., Ueda, M., Ikeda, F., Matsubara, T., Ichida, F., Hisada, K., Nokubi, T., Yamaguchi, A. & Yoneda, T., Mar 1 2005, In : Molecular and cellular biology. 25, 5, p. 1971-1979 9 p.

Research output: Contribution to journalArticle

Open Access
67 Citations (Scopus)

An essential role for mitochondrial aldehyde dehydrogenase in nitroglycerin bioactivation

Chen, Z., Foster, M. W., Zhang, J., Mao, L., Rockman, H. A., Kawamoto, T., Kitagawa, K., Nakayama, K., Hess, D. T. & Stamler, J. S., Aug 23 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 34, p. 12159-12164 6 p.

Research output: Contribution to journalArticle

174 Citations (Scopus)

Bcl-2-related protein A1 is an endogenous and cytokine-stimulated mediator of cytoprotection in hyperoxic acute lung injury

He, C. H., Waxman, A. B., Lee, C. G., Link, H., Rabach, M. E., Ma, B., Chen, Q., Zhu, Z., Zhong, M., Nakayama, K., Nakayama, K. I., Homer, R. & Elias, J. A., Apr 2005, In : Journal of Clinical Investigation. 115, 4, p. 1039-1048 10 p.

Research output: Contribution to journalArticle

70 Citations (Scopus)

Cell surface expression of CD147/EMMPRIN is regulated by cyclophilin 60

Pushkarsky, T., Yurchenko, V., Vanpouille, C., Brichacek, B., Vaisman, I., Hatakeyama, S., Nakayama, K. I., Sherry, B. & Bukrinsky, M. I., Jul 29 2005, In : Journal of Biological Chemistry. 280, 30, p. 27866-27871 6 p.

Research output: Contribution to journalArticle

60 Citations (Scopus)

Deletion of Cdkn1b ameliorates hyperglycemia by maintaining compensatory hyperinsulinemia in diabetic mice

Uchida, T., Nakamura, T., Hashimoto, N., Matsuda, T., Kotani, K., Sakaue, H., Kido, Y., Hayashi, Y., Nakayama, K. I., White, M. F. & Kasuga, M., Feb 1 2005, In : Nature medicine. 11, 2, p. 175-182 8 p.

Research output: Contribution to journalArticle

159 Citations (Scopus)

Disappearance of p27(KIP1) and increase in proliferation of the lens cells after extraction of most of the fiber cells of the lens

Kase, S., Yoshida, K., Ikeda, H., Harada, T., Harada, C., Imaki, J., Ohgami, K., Shiratori, K., Nakayama, K., Nakayama, K. & Ohno, S., Jul 1 2005, In : Current Eye Research. 30, 6, p. 437-442 6 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Interaction of presenilins with FKBP38 promotes apoptosis by reducing mitochondrial Bcl-2

Wang, H. Q., Nakaya, Y., Du, Z., Yamane, T., Shirane, M., Kudo, T., Takeda, M., Takebayashi, K., Noda, Y., Nakayama, K. & Nishimura, M., Jul 1 2005, In : Human Molecular Genetics. 14, 13, p. 1889-1902 14 p.

Research output: Contribution to journalArticle

73 Citations (Scopus)

Large-scale analysis of the human ubiquitin-related proteome

Matsumoto, M., Hatakeyama, S., Oyamada, K., Oda, Y., Nishimura, T. & Nakayama, K. I., Nov 1 2005, In : Proteomics. 5, 16, p. 4145-4151 7 p.

Research output: Contribution to journalArticle

144 Citations (Scopus)

Mammalian E4 is required for cardiac development and maintenance of the nervous system

Kaneko-Oshikawa, C., Nakagawa, T., Yamada, M., Yoshikawa, H., Matsumoto, M., Yada, M., Hatakeyama, S., Nakayama, K. & Nakayama, K. I., Dec 1 2005, In : Molecular and cellular biology. 25, 24, p. 10953-10964 12 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)

Molecular dissection of the interaction between p27 and Kip1 ubiquitylation-promoting complex, the ubiquitin ligase that regulates proteolysis of p27 in G1 phase

Kotoshibai, S., Kamura, T., Hara, T., Ishida, N. & Nakayama, K., May 6 2005, In : Journal of Biological Chemistry. 280, 18, p. 17694-17700 7 p.

Research output: Contribution to journalArticle

67 Citations (Scopus)

Noncovalent SUMO-1 binding activity of thymine DNA glycosylase (TDG) is required for its SUMO-1 modification and colocalization with the promyelocytic leukemia protein

Takahashi, H., Hatakeyama, S., Saitoh, H. & Nakayama, K. I., Feb 18 2005, In : Journal of Biological Chemistry. 280, 7, p. 5611-5621 11 p.

Research output: Contribution to journalArticle

88 Citations (Scopus)

p107 inhibits G1 to S phase progression by down-regulating expression of the F-box protein Skp2

Rodier, G., Makris, C., Coulombe, P., Scime, A., Nakayama, K., Nakayama, K. I. & Meloche, S., Jan 3 2005, In : Journal of Cell Biology. 168, 1, p. 55-66 12 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

Phosphorylation of β-catenin by cyclic AMP-dependent protein kinase stabilizes β-catenin through inhibition of its ubiquitination

Hino, S. I., Tanji, C., Nakayama, K. I. & Kikuchi, A., Oct 1 2005, In : Molecular and cellular biology. 25, 20, p. 9063-9072 10 p.

Research output: Contribution to journalArticle

269 Citations (Scopus)

Role of PRIP-1, a novel Ins(1,4,5)P3 binding protein, in Ins(1,4,5)P3-mediated Ca2+ signaling

Harada, K., Takeuchi, H., Oike, M., Matsuda, M., Kanematsu, T., Yagisawa, H., Nakayama, K. I. I., Maeda, K., Erneux, C. & Hirata, M., Feb 1 2005, In : Journal of cellular physiology. 202, 2, p. 422-433 12 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Role of serine 10 phosphorylation in p27 stabilization revealed by analysis of p27 knock-in mice harboring a serine 10 mutation

Kotake, Y., Nakayama, K., Ishida, N. & Nakayama, K., Jan 14 2005, In : Journal of Biological Chemistry. 280, 2, p. 1095-1102 8 p.

Research output: Contribution to journalArticle

62 Citations (Scopus)

Role of the UBL-UBA protein KPC2 in degradation of p27 at G1 phase of the cell cycle

Hara, T., Kamura, T., Kotoshiba, S., Takahashi, H., Fujiwara, K., Onoyama, I., Shirakawa, M., Mizushima, N. & Nakayama, K. I., Nov 1 2005, In : Molecular and cellular biology. 25, 21, p. 9292-9303 12 p.

Research output: Contribution to journalArticle

57 Citations (Scopus)

Suppression of cell migration by protein kinase Cδ

Jackson, D., Zheng, Y., Lyo, D., Shen, Y., Nakayama, K., Nakayama, K. I., Humphries, M. J., Reyland, M. E. & Foster, D. A., Apr 21 2005, In : Oncogene. 24, 18, p. 3067-3072 6 p.

Research output: Contribution to journalArticle

47 Citations (Scopus)

Targeted destruction of c-Myc by an engineered ubiquitin ligase suppresses cell transformation and tumor formation

Hatakeyama, S., Watanabe, M., Fujii, Y. & Nakayama, K. I., Sep 1 2005, In : Cancer Research. 65, 17, p. 7874-7879 6 p.

Research output: Contribution to journalArticle

41 Citations (Scopus)