Department of Molecular and Cellular Biology

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2005

Role of PRIP-1, a novel Ins(1,4,5)P3 binding protein, in Ins(1,4,5)P3-mediated Ca2+ signaling

Harada, K., Takeuchi, H., Oike, M., Matsuda, M., Kanematsu, T., Yagisawa, H., Nakayama, K. I. I., Maeda, K., Erneux, C. & Hirata, M., Feb 1 2005, In : Journal of cellular physiology. 202, 2, p. 422-433 12 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Role of serine 10 phosphorylation in p27 stabilization revealed by analysis of p27 knock-in mice harboring a serine 10 mutation

Kotake, Y., Nakayama, K., Ishida, N. & Nakayama, K. I., Jan 14 2005, In : Journal of Biological Chemistry. 280, 2, p. 1095-1102 8 p.

Research output: Contribution to journalArticle

62 Citations (Scopus)

Role of the UBL-UBA protein KPC2 in degradation of p27 at G1 phase of the cell cycle

Hara, T., Kamura, T., Kotoshiba, S., Takahashi, H., Fujiwara, K., Onoyama, I., Shirakawa, M., Mizushima, N. & Nakayama, K. I., Nov 1 2005, In : Molecular and cellular biology. 25, 21, p. 9292-9303 12 p.

Research output: Contribution to journalArticle

57 Citations (Scopus)

Suppression of cell migration by protein kinase Cδ

Jackson, D., Zheng, Y., Lyo, D., Shen, Y., Nakayama, K., Nakayama, K. I., Humphries, M. J., Reyland, M. E. & Foster, D. A., Apr 21 2005, In : Oncogene. 24, 18, p. 3067-3072 6 p.

Research output: Contribution to journalArticle

47 Citations (Scopus)

Targeted destruction of c-Myc by an engineered ubiquitin ligase suppresses cell transformation and tumor formation

Hatakeyama, S., Watanabe, M., Fujii, Y. & Nakayama, K. I., Sep 1 2005, In : Cancer Research. 65, 17, p. 7874-7879 6 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)

Ubiquitylation and degradation of serum-inducible kinase by hVPS18, a RING-H2 type ubiquitin ligase

Yogosawa, S., Hatakeyama, S., Nakayama, K., Miyoshi, H., Kohsaka, S. & Akazawa, C., Dec 16 2005, In : Journal of Biological Chemistry. 280, 50, p. 41619-41627 9 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Ubiquitylation of RAG-2 by Skp2-SCF links destruction of the V(D)J recombinase to the cell cycle

Jiang, H., Chang, F. C., Ross, A. E., Lee, J., Nakayama, K., Nakayama, K. & Desiderio, S., Jun 10 2005, In : Molecular Cell. 18, 6, p. 699-709 11 p.

Research output: Contribution to journalArticle

87 Citations (Scopus)
2004

Abnormal angiogenesis in Foxo1 (Fkhr)-deficient mice

Furuyama, T., Kitayama, K., Shimoda, Y., Ogawa, M., Sone, K., Yoshida-Araki, K., Hisatsune, H., Nishikawa, S. I., Nakayama, K., Nakayama, K., Ikeda, K., Motoyama, N. & Mori, N., Aug 13 2004, In : Journal of Biological Chemistry. 279, 33, p. 34741-34749 9 p.

Research output: Contribution to journalArticle

244 Citations (Scopus)

AIRE Functions as an E3 Ubiquitin Ligase

Uchida, D., Hatakeyama, S., Matsushima, A., Han, H., Ishido, S., Hotta, H., Kudoh, J., Shimizu, N., Doucas, V., Nakayama, K. I., Kuroda, N. & Matsumoto, M., Jan 19 2004, In : Journal of Experimental Medicine. 199, 2, p. 167-172 6 p.

Research output: Contribution to journalArticle

120 Citations (Scopus)

ASC is a Bax adaptor and regulates the p53-Bax mitochondrial apoptosis pathway

Ohtsuka, T., Ryu, H., Minamishima, Y. A., Macip, S., Sagara, J., Nakayama, K. I., Aaronson, S. A. & Lee, S. W., Feb 1 2004, In : Nature Cell Biology. 6, 2, p. 121-128 8 p.

Research output: Contribution to journalArticle

176 Citations (Scopus)

CHIP promotes proteasomal degradation of familial ALS-linked mutant SOD1 by ubiquitinating Hsp/Hsc70

Urushitani, M., Kurisu, J., Tateno, M., Hatakeyama, S., Nakayama, K., Kato, S. & Takahashi, R., Jul 1 2004, In : Journal of Neurochemistry. 90, 1, p. 231-244 14 p.

Research output: Contribution to journalArticle

135 Citations (Scopus)

Cooperative regulation of the cell division cycle by the protein kinases RAF and AKT

Mirza, A. M., Gysin, S., Malek, N., Nakayama, K. I., Roberts, J. M. & McMahon, M., Dec 1 2004, In : Molecular and cellular biology. 24, 24, p. 10868-10881 14 p.

Research output: Contribution to journalArticle

94 Citations (Scopus)

Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27Kip1 at G1 phase

Kamura, T., Hara, T., Matsumoto, M., Ishida, N., Okumura, F., Hatakeyama, S., Yoshida, M., Nakayama, K. & Nakayama, K., Dec 1 2004, In : Nature Cell Biology. 6, 12, p. 1229-1235 7 p.

Research output: Contribution to journalArticle

320 Citations (Scopus)

Distinct roles of c-Abl and Atm in oxidative stress response are mediated by protein kinase C δ

Li, B., Wang, X., Rasheed, N., Hu, Y., Boast, S., Ishii, T., Nakayama, K., Nakayama, K. I. & Golf, S. P., Aug 1 2004, In : Genes and Development. 18, 15, p. 1824-1837 14 p.

Research output: Contribution to journalArticle

88 Citations (Scopus)

Distribution of p27(KIP1), cylin D1, and proliferating cell nuclear antigen after retinal detachment

Yoshida, K., Kase, S., Nakayama, K., Nagahama, H., Harada, T., Ikeda, H., Harada, C., Imaki, J., Ohgami, K., Shiratori, K., Ohno, S. & Nakayama, K., May 1 2004, In : Graefe's Archive for Clinical and Experimental Ophthalmology. 242, 5, p. 437-441 5 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Down-regulation of p27Kip1 promotes cell proliferation of rat neonatal cardiomyocytes induced by nuclear expression of cyclin D1 and CDK4: Evidence for impaired Skp2-dependent degradation of p27 in terminal differentiation

Tamamori-Adachi, M., Hayashida, K., Nobori, K., Omizu, C., Yamada, K., Sakamoto, N., Kamura, T., Fukuda, K., Ogawa, S., Nakayama, K. I. & Kitajima, S., Nov 26 2004, In : Journal of Biological Chemistry. 279, 48, p. 50429-50436 8 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Early embryonic death in mice lacking the β-catenin-binding protein duplin

Nishiyama, M., Nakayama, K., Tsunematsu, R., Tsukiyama, T., Kikuchi, A. & Nakayama, K. I., Oct 1 2004, In : Molecular and cellular biology. 24, 19, p. 8386-8394 9 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene

Mao, J. H., Perez-Iosada, J., Wu, D., DelRosario, R., Tsunematsu, R., Nakayama, K. I., Brown, K., Bryson, S. & Balmain, A., Dec 9 2004, In : Nature. 432, 7018, p. 775-779 5 p.

Research output: Contribution to journalArticle

277 Citations (Scopus)

Functional regulation of FEZ1 by the U-box-type ubiquitin ligase E4B contributes to neuritogenesis

Okumura, F., Hatakeyama, S., Matsumoto, M., Kamura, T. & Nakayama, K. I., Dec 17 2004, In : Journal of Biological Chemistry. 279, 51, p. 53533-53543 11 p.

Research output: Contribution to journalArticle

41 Citations (Scopus)

GABAA receptor phospho-dependent modulation is regulated by phospholipase C-related inactive protein type 1, a novel protein phosphatase 1 anchoring protein

Terunuma, M., Jang, I. S., Ha, S. H., Kittler, J. T., Kanematsu, T., Jovanovic, J. N., Nakayama, K. I., Akaike, N., Ryu, S. H., Moss, S. J. & Hirata, M., Aug 11 2004, In : Journal of Neuroscience. 24, 32, p. 7074-7084 11 p.

Research output: Contribution to journalArticle

86 Citations (Scopus)

Hypersensitivity to pentylenetetrazol-induced convulsion in mice lacking the PLC-related inactive protein-1

Yamaguchi, T., Kubota, T., Kanematsu, T., Nakayama, K., Hirata, M. & Yamamoto, T., Oct 29 2004, In : Brain Research. 1025, 1-2, p. 237-240 4 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Interaction of U-box-type ubiquitin-protein ligases (E3s) with molecular chaperones

Hatakeyama, S., Matsumoto, M., Yada, M. & Nakayama, K., Jun 1 2004, In : Genes to Cells. 9, 6, p. 533-548 16 p.

Research output: Contribution to journalArticle

70 Citations (Scopus)

Involvement of p27(KIP1) in proliferation of the retinal pigment epithelium and ciliary body

Yoshida, K., Nakayama, K., Kase, S., Nagahama, H., Harada, T., Ikeda, H., Harada, C., Imaki, J., Ohgami, K., Shiratori, K., Ohno, S., Nishi, S. & Nakayama, K. I., May 1 2004, In : Anatomy and Embryology. 208, 2, p. 145-150 6 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Involvement of p27KIP1 in the proliferation of the developing corneal endothelium

Yoshida, K., Kase, S., Nakayama, K., Nagahama, H., Harada, T., Ikeda, H., Harada, C., Imaki, J., Ohgami, K., Shiratori, K., Ilieva, I. B., Ohno, S., Nishi, S. & Nakayama, K. I., Jul 1 2004, In : Investigative Ophthalmology and Visual Science. 45, 7, p. 2163-2167 5 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Molecular clearance of ataxin-3 is regulated by a mammalian E4

Matsumoto, M., Yada, M., Hatakeyama, S., Ishimoto, H., Tanimura, T., Tsuji, S., Kakizuka, A., Kitagawa, M. & Nakayama, K. I., Feb 11 2004, In : EMBO Journal. 23, 3, p. 659-669 11 p.

Research output: Contribution to journalArticle

113 Citations (Scopus)

Mouse Fbw7/Sel-10/Cdc4 Is Required for Notch Degradation during Vascular Development

Tsunematsu, R., Nakayama, K., Oike, Y., Nishiyama, M., Ishida, N., Hatakeyama, S., Bessho, Y., Kageyama, R., Suda, T. & Nakayama, K., Mar 5 2004, In : Journal of Biological Chemistry. 279, 10, p. 9417-9423 7 p.

Research output: Contribution to journalArticle

193 Citations (Scopus)

Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7

Yada, M., Hatakeyama, S., Kamura, T., Nishiyama, M., Tsunematsu, R., Imaki, H., Ishida, N., Okumura, F., Nakayama, K. & Nakayama, K. I., May 19 2004, In : EMBO Journal. 23, 10, p. 2116-2125 10 p.

Research output: Contribution to journalArticle

493 Citations (Scopus)

Reciprocal roles of Msx2 in regulation of osteoblast and adipocyte differentiation

Ichida, F., Nishimura, R., Hata, K., Matsubara, T., Ikeda, F., Hisada, K., Yatani, H., Cao, X., Komori, T., Yamaguchi, A. & Yoneda, T., Aug 6 2004, In : Journal of Biological Chemistry. 279, 32, p. 34015-34022 8 p.

Research output: Contribution to journalArticle

Open Access
147 Citations (Scopus)

Skp2-Mediated degradation of p27 regulates progression into mitosis

Nakayama, K., Nagahama, H., Minamishima, Y. A., Miyake, S., Ishida, N., Hatakeyama, S., Kitagawa, M., Iemura, S. I., Natsume, T. & Nakayama, K. I., May 1 2004, In : Developmental Cell. 6, 5, p. 661-672 12 p.

Research output: Contribution to journalArticle

271 Citations (Scopus)

Small ubiquitin-like modifier 1 (SUMO-1) modification of the synergy control motif of Ad4 binding protein/steroidogenic factor 1 (Ad4BP/SF-1) regulates synergistic transcription between Ad4BP/SF-1 and Sox9

Komatsu, T., Mizusaki, H., Mukai, T., Ogawa, H., Baba, D., Shirakawa, M., Hatakeyama, S., Nakayama, K. I., Yamamoto, H., Kikuchi, A. & Morohashi, K. I., Oct 1 2004, In : Molecular Endocrinology. 18, 10, p. 2451-2462 12 p.

Research output: Contribution to journalArticle

91 Citations (Scopus)

SOCS1 is a suppressor of liver fibrosis and hepatitis-induced carcinogenesis

Yoshida, T., Ogata, H., Kamio, M., Joo, A., Shiraishi, H., Tokunaga, Y., Sata, M., Nagai, H. & Yoshimura, A., Jun 21 2004, In : Journal of Experimental Medicine. 199, 12, p. 1701-1707 7 p.

Research output: Contribution to journalArticle

128 Citations (Scopus)

STAT3 and MITF cooperatively induce cellular transformation through upregulation of c-fos expression

Joo, A., Aburatani, H., Morii, E., Iba, H. & Yoshimura, A., Jan 22 2004, In : Oncogene. 23, 3, p. 726-734 9 p.

Research output: Contribution to journalArticle

Open Access
40 Citations (Scopus)

Subcellular expression of autoimmune regulator is organized in a spatiotemporal manner

Akiyoshi, H., Hatakeyama, S., Pitkänen, J., Mouri, Y., Doucas, V., Kudoh, J., Tsurugaya, K., Uchida, D., Matsushima, A., Oshikawa, K., Nakayama, K. I., Shimizu, N., Peterson, P. & Matsumoto, M., Aug 6 2004, In : Journal of Biological Chemistry. 279, 32, p. 33984-33991 8 p.

Research output: Contribution to journalArticle

51 Citations (Scopus)

The ISG15 isopeptidase UBP43 is regulated by proteolysis via the SCF Skp2 ubiquitin ligase

Tokarz, S., Berset, C., La Rue, J., Friedman, K., Nakayama, K. I., Nakayama, K., Zhang, D. E. & Lanker, S., Nov 5 2004, In : Journal of Biological Chemistry. 279, 45, p. 46424-46430 7 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

The Papillomavirus E7 Oncoprotein Is Ubiquitinated by UbcH7 and Cullin 1- and Skp2-Containing E3 Ligase

Oh, K. J., Kalinina, A., Wang, J., Nakayama, K., Nakayama, K. I. & Bagchi, S., May 1 2004, In : Journal of virology. 78, 10, p. 5338-5346 9 p.

Research output: Contribution to journalArticle

60 Citations (Scopus)

Tyk2 is essential for IFN-α-induced gene expression in mast cells

Mori, Y., Hirose, K., Suzuki, K., Nakajima, H., Seto, Y., Ikeda, K., Shimoda, K., Nakayama, K. I., Saito, Y. & Iwamoto, I., Jun 15 2004, In : International Archives of Allergy and Immunology. 134, SUPPL. 1, p. 25-29 5 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases

Kamura, T., Maenaka, K., Kotoshiba, S., Matsumoto, M., Kohda, D., Conaway, R. C., Conaway, J. W. & Nakayama, K. I., Dec 15 2004, In : Genes and Development. 18, 24, p. 3055-3065 11 p.

Research output: Contribution to journalArticle

316 Citations (Scopus)
2003

A novel route for connexin 43 to inhibit cell proliferation: Negative regulation of S-phase kinase-associated protein (Skp 2)

Zhang, Y. W., Nakayama, K., Nakayama, K. & Morita, I., Apr 1 2003, In : Cancer Research. 63, 7, p. 1623-1630 8 p.

Research output: Contribution to journalArticle

110 Citations (Scopus)

Association of Cathepsin E Deficiency with Development of Atopic Dermatitis

Tsukuba, T., Okamoto, K., Okamoto, Y., Yanagawa, M., Kohmura, K., Yasuda, Y., Uchi, H., Nakahara, T., Furue, M., Nakayama, K., Kadowaki, T., Yamamoto, K. & Nakayama, K. I., Dec 1 2003, In : Journal of biochemistry. 134, 6, p. 893-902 10 p.

Research output: Contribution to journalArticle

65 Citations (Scopus)

Cell cycle-dependent regulation of the Skp2 promoter by GA-binding protein

Imaki, H., Nakayama, K., Delehouzee, S., Handa, H., Kitagawa, M., Kamura, T. & Nakayama, K. I., Aug 1 2003, In : Cancer Research. 63, 15, p. 4607-4613 7 p.

Research output: Contribution to journalArticle

69 Citations (Scopus)

Characterization of the mouse gene for the U-box-type ubiquitin ligase UFD2a

Kaneko, C., Hatakeyama, S., Matsumoto, M., Yada, M., Nakayama, K. & Nakayama, K., Jan 10 2003, In : Biochemical and Biophysical Research Communications. 300, 2, p. 297-304 8 p.

Research output: Contribution to journalArticle

47 Citations (Scopus)

CIS1 interacts with the Y532 of the prolactin receptor and suppresses prolactin-dependent STAT5 activation

Endo, T., Sasaki, A., Minoguchi, M., Joo, A. & Yoshimura, A., Jan 1 2003, In : Journal of biochemistry. 133, 1, p. 109-113 5 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Control mechanism of JAK/STAT signal transduction pathway

Yamada, S., Shiono, S., Joo, A. & Yoshimura, A., Jan 16 2003, In : FEBS Letters. 534, 1-3, p. 190-196 7 p.

Research output: Contribution to journalArticle

143 Citations (Scopus)

Degradation of p57Kip2 mediated by SCFSkp2-dependent ubiquitylation

Kamura, T., Hara, T., Kotoshiba, S., Yada, M., Ishida, N., Imaki, H., Hatakeyama, S., Nakayama, K. & Nakayama, K. I., Sep 2 2003, In : Proceedings of the National Academy of Sciences of the United States of America. 100, 18, p. 10231-10236 6 p.

Research output: Contribution to journalArticle

224 Citations (Scopus)

Differential roles of Smad1 and p38 kinase in regulation of peroxisome proliferator-activating receptor γ during bone morphogenetic protein 2-induced adipogenesis

Hata, K., Nishimura, R., Ikeda, F., Yamashita, K., Matsubara, T., Nokubi, T. & Yoneda, T., Feb 1 2003, In : Molecular biology of the cell. 14, 2, p. 545-555 11 p.

Research output: Contribution to journalArticle

131 Citations (Scopus)

Enhanced Th2 cell-mediated allergic inflammation in Tyk2-deficient mice

Seto, Y., Nakajima, H., Suto, A., Shimoda, K., Saito, Y., Nakayama, K. I. & Iwamoto, I., Jan 15 2003, In : Journal of Immunology. 170, 2, p. 1077-1083 7 p.

Research output: Contribution to journalArticle

50 Citations (Scopus)

Estrogens Down-regulate p27Kip1 in Breast Cancer Cells through Skp2 and through Nuclear Export Mediated by the ERK Pathway

Foster, J. S., Fernando, R. I., Ishida, N., Nakayama, K. I. & Wimalasena, J., Oct 17 2003, In : Journal of Biological Chemistry. 278, 42, p. 41355-41366 12 p.

Research output: Contribution to journalArticle

84 Citations (Scopus)

Impaired degradation of inhibitory subunit of NF-κB (IκB) and β-catenin as a result of targeted disruption of the β-TrCP1 gene

Nakayama, K., Hatakeyama, S., Maruyama, S. I., Kikuchi, A., Onoé, K., Good, R. A. & Nakayama, K. I., Jul 22 2003, In : Proceedings of the National Academy of Sciences of the United States of America. 100, 15, p. 8752-8757 6 p.

Research output: Contribution to journalArticle

81 Citations (Scopus)

Intracellular signal transduction of interferon on the suppression of haematopoietic progenitor cell growth

Kato, K., Kamezaki, K., Shimoda, K., Numata, A., Haro, T., Aoki, K., Ishikawa, F., Takase, K., Ariyama, H., Matsuda, T., Miyamoto, T., Nagafuji, K., Gondo, H., Nakayama, K. I. & Harada, M., Nov 1 2003, In : British Journal of Haematology. 123, 3, p. 528-535 8 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Limitin, an interferon-like cytokine, transduces inhibitory signals on B-cell growth through activation of Tyk2, but not Stat1, followed by induction and nuclear translocation of Daxx

Aoki, K., Shimoda, K., Oritani, K., Matsuda, T., Kamezaki, K., Muromoto, R., Numata, A., Tamiya, S., Haro, T., Ishikawa, F., Takase, K., Yamamoto, T., Yumioka, T., Miyamoto, T., Nagafuji, K., Gondo, H., Nagafuchi, S., Nakayama, K. I. & Harada, M., Dec 2003, In : Experimental Hematology. 31, 12, p. 1317-1322 6 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)