Department of Molecular and Cellular Biology

Research Output 1989 2020

Filter
Article
2003
110 Citations (Scopus)

A novel route for connexin 43 to inhibit cell proliferation: Negative regulation of S-phase kinase-associated protein (Skp 2)

Zhang, Y. W., Nakayama, K., Nakayama, K. & Morita, I., Apr 1 2003, In : Cancer Research. 63, 7, p. 1623-1630 8 p.

Research output: Contribution to journalArticle

S-Phase Kinase-Associated Proteins
Connexin 43
Cell Proliferation
Embryonic Structures
Fibroblasts
65 Citations (Scopus)

Association of Cathepsin E Deficiency with Development of Atopic Dermatitis

Tsukuba, T., Okamoto, K., Okamoto, Y., Yanagawa, M., Kohmura, K., Yasuda, Y., Uchi, H., Nakahara, T., Furue, M., Nakayama, K., Kadowaki, T., Yamamoto, K. & Nakayama, K. I., Dec 1 2003, In : Journal of biochemistry. 134, 6, p. 893-902 10 p.

Research output: Contribution to journalArticle

Cathepsin E
Atopic Dermatitis
Interleukin-18
Interleukin-1
T-cells
68 Citations (Scopus)

Cell cycle-dependent regulation of the Skp2 promoter by GA-binding protein

Imaki, H., Nakayama, K., Delehouzee, S., Handa, H., Kitagawa, M., Kamura, T. & Nakayama, K. I., Aug 1 2003, In : Cancer Research. 63, 15, p. 4607-4613 7 p.

Research output: Contribution to journalArticle

GA-Binding Protein Transcription Factor
Cell Cycle
Electrophoretic Mobility Shift Assay
S Phase
Genetic Promoter Regions
47 Citations (Scopus)

Characterization of the mouse gene for the U-box-type ubiquitin ligase UFD2a

Kaneko, C., Hatakeyama, S., Matsumoto, M., Yada, M., Nakayama, K. & Nakayama, K., Jan 10 2003, In : Biochemical and Biophysical Research Communications. 300, 2, p. 297-304 8 p.

Research output: Contribution to journalArticle

Ligases
Ubiquitin
Genes
TATA Box
5' Flanking Region
25 Citations (Scopus)

CIS1 interacts with the Y532 of the prolactin receptor and suppresses prolactin-dependent STAT5 activation

Endo, T., Sasaki, A., Minoguchi, M., Joo, A. & Yoshimura, A., Jan 1 2003, In : Journal of biochemistry. 133, 1, p. 109-113 5 p.

Research output: Contribution to journalArticle

Prolactin Receptors
Prolactin
Chemical activation
Yeast
Transcription
143 Citations (Scopus)

Control mechanism of JAK/STAT signal transduction pathway

Yamada, S., Shiono, S., Joo, A. & Yoshimura, A., Jan 16 2003, In : FEBS Letters. 534, 1-3, p. 190-196 7 p.

Research output: Contribution to journalArticle

Janus Kinases
Signal transduction
Transcription
Transducers
Phosphoric Monoester Hydrolases
220 Citations (Scopus)

Degradation of p57Kip2 mediated by SCFSkp2-dependent ubiquitylation

Kamura, T., Hara, T., Kotoshiba, S., Yada, M., Ishida, N., Imaki, H., Hatakeyama, S., Nakayama, K. & Nakayama, K. I., Sep 2 2003, In : Proceedings of the National Academy of Sciences of the United States of America. 100, 18, p. 10231-10236 6 p.

Research output: Contribution to journalArticle

Ubiquitination
Cyclin-Dependent Kinase Inhibitor p57
Cell Cycle
Cyclin E
Ubiquitin-Protein Ligases
130 Citations (Scopus)

Differential roles of Smad1 and p38 kinase in regulation of peroxisome proliferator-activating receptor γ during bone morphogenetic protein 2-induced adipogenesis

Hata, K., Nishimura, R., Ikeda, F., Yamashita, K., Matsubara, T., Nokubi, T. & Yoneda, T., Feb 1 2003, In : Molecular biology of the cell. 14, 2, p. 545-555 11 p.

Research output: Contribution to journalArticle

Peroxisome Proliferators
Adipogenesis
Bone Morphogenetic Protein 2
Phosphotransferases
Adipocytes
67 Citations (Scopus)

Effects of oral UFT combined with or without zoledronic acid on bone metastasis in the 4T1/luc mouse breast cancer

Hiraga, T., Ueda, A., Tamura, D., Hata, K., Ikeda, F., Williams, P. J. & Yoneda, T., Oct 10 2003, In : International Journal of Cancer. 106, 6, p. 973-979 7 p.

Research output: Contribution to journalArticle

Open Access
zoledronic acid
Breast Neoplasms
Neoplasm Metastasis
Bone and Bones
Diphosphonates
49 Citations (Scopus)

Enhanced Th2 cell-mediated allergic inflammation in Tyk2-deficient mice

Seto, Y., Nakajima, H., Suto, A., Shimoda, K., Saito, Y., Nakayama, K. I. & Iwamoto, I., Jan 15 2003, In : Journal of Immunology. 170, 2, p. 1077-1083 7 p.

Research output: Contribution to journalArticle

Th2 Cells
Inflammation
Interleukin-13
Interleukin-12
Eosinophils
84 Citations (Scopus)

Estrogens Down-regulate p27Kip1 in Breast Cancer Cells through Skp2 and through Nuclear Export Mediated by the ERK Pathway

Foster, J. S., Fernando, R. I., Ishida, N., Nakayama, K. I. & Wimalasena, J., Oct 17 2003, In : Journal of Biological Chemistry. 278, 42, p. 41355-41366 12 p.

Research output: Contribution to journalArticle

Cell Nucleus Active Transport
Extracellular Signal-Regulated MAP Kinases
MCF-7 Cells
Estrogens
Estrogen Receptor Modulators
113 Citations (Scopus)

Glucagon-like peptide 1 (1-37) converts intestinal epithelial cells into insulin-producing cells

Suzuki, A., Nakauchi, H. & Taniguchi, H., Apr 29 2003, In : Proceedings of the National Academy of Sciences of the United States of America. 100, 9, p. 5034-5039 6 p.

Research output: Contribution to journalArticle

Epithelial Cells
Insulin
Proglucagon
Glucagon-Like Peptide 1
Pancreas
81 Citations (Scopus)

Impaired degradation of inhibitory subunit of NF-κB (IκB) and β-catenin as a result of targeted disruption of the β-TrCP1 gene

Nakayama, K., Hatakeyama, S., Maruyama, S. I., Kikuchi, A., Onoé, K., Good, R. A. & Nakayama, K. I., Jul 22 2003, In : Proceedings of the National Academy of Sciences of the United States of America. 100, 15, p. 8752-8757 6 p.

Research output: Contribution to journalArticle

Catenins
Genes
F-Box Proteins
Wnt Signaling Pathway
Polyploidy
22 Citations (Scopus)

Intracellular signal transduction of interferon on the suppression of haematopoietic progenitor cell growth

Kato, K., Kamezaki, K., Shimoda, K., Numata, A., Haro, T., Aoki, K., Ishikawa, F., Takase, K., Ariyama, H., Matsuda, T., Miyamoto, T., Nagafuji, K., Gondo, H., Nakayama, K. I. & Harada, M., Nov 1 2003, In : British Journal of Haematology. 123, 3, p. 528-535 8 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
Interferons
Signal Transduction
TYK2 Kinase
Growth
13 Citations (Scopus)

Limitin, an interferon-like cytokine, transduces inhibitory signals on B-cell growth through activation of Tyk2, but not Stat1, followed by induction and nuclear translocation of Daxx

Aoki, K., Shimoda, K., Oritani, K., Matsuda, T., Kamezaki, K., Muromoto, R., Numata, A., Tamiya, S., Haro, T., Ishikawa, F., Takase, K., Yamamoto, T., Yumioka, T., Miyamoto, T., Nagafuji, K., Gondo, H., Nagafuchi, S., Nakayama, K. I. & Harada, M., Dec 2003, In : Experimental Hematology. 31, 12, p. 1317-1322 6 p.

Research output: Contribution to journalArticle

Interferons
B-Lymphocytes
Cytokines
Growth
Interferon Regulatory Factor-1

Mechanisms to control degradation of polyglutamine-containing protein

Nakayama, K. I., Nov 1 2003, In : Clinical Neurology. 43, 11, p. 906-908 3 p.

Research output: Contribution to journalArticle

Machado-Joseph Disease
Ubiquitination
Proteins
Reticulocytes
Proteasome Endopeptidase Complex
49 Citations (Scopus)

p57KIP2 Modulates Stress-activated Signaling by Inhibiting c-Jun NH2-terminal Kinase/Stress-activated Protein Kinase

Chang, T. S., Kim, M. J., Ryoo, K., Park, J., Eom, S. J., Shim, J., Nakayama, K. I., Nakayama, K., Tomita, M., Takahashi, K., Lee, M. J. & Choi, E. J., Nov 28 2003, In : Journal of Biological Chemistry. 278, 48, p. 48092-48098 7 p.

Research output: Contribution to journalArticle

JNK Mitogen-Activated Protein Kinases
Heat-Shock Proteins
Protein Kinases
Beckwith-Wiedemann Syndrome
Cyclin-Dependent Kinases
51 Citations (Scopus)

Preferential interaction of TIP120A with Cul1 that is not modified by NEDD8 and not associated with Skp1

Oshikawa, K., Matsumoto, M., Yada, M., Kamura, T., Hatakeyama, S. & Nakayama, K. I., Apr 18 2003, In : Biochemical and Biophysical Research Communications. 303, 4, p. 1209-1216 8 p.

Research output: Contribution to journalArticle

F-Box Proteins
TATA-Box Binding Protein
Ubiquitin-Protein Ligases
Ligases
Ubiquitin
49 Citations (Scopus)

STAP-2/BKS, an adaptor/docking protein, modulates STAT3 activation in acute-phase response through its YXXQ motif

Minoguchi, M., Minoguchi, S., Aki, D., Joo, A., Yamamoto, T., Yumioka, T., Matsuda, T. & Yoshimura, A., Mar 28 2003, In : Journal of Biological Chemistry. 278, 13, p. 11182-11189 8 p.

Research output: Contribution to journalArticle

Open Access
Signal Transducing Adaptor Proteins
STAT3 Transcription Factor
Acute-Phase Reaction
Chemical activation
Molecules
354 Citations (Scopus)

The F-box protein Skp2 participates in c-Myc proteosomal degradation and acts as a cofactor for c-Myc-regulated transcription

Von Der Lehr, N., Johansson, S., Wu, S., Bahram, F., Castell, A., Cetinkaya, C., Hydbring, P., Weidung, I., Nakayama, K., Nakayama, K. I., Söderberg, O., Kerppola, T. K. & Larsson, L. G., May 1 2003, In : Molecular Cell. 11, 5, p. 1189-1200 12 p.

Research output: Contribution to journalArticle

F-Box Proteins
myc Genes
Ubiquitination
Phase Transition
Proteasome Endopeptidase Complex
17 Citations (Scopus)

The second phase activation of protein kinase C δ at late G1 is required for DNA synthesis in serum-induced cell cycle progression

Kitamura, K., Mizuno, K., Etoh, A., Akita, Y., Miyamoto, A., Nakayama, K. & Ohno, S., Apr 1 2003, In : Genes to Cells. 8, 4, p. 311-324 14 p.

Research output: Contribution to journalArticle

Protein Kinase C
Cell Cycle
DNA
Serum
Cell Division
21 Citations (Scopus)

Vasopressin-induced contraction of uterus is mediated solely by the oxytocin receptor in mice, but not in humans

Kawamata, M., Mitsui-Saito, M., Kimura, T., Takayanagi, Y., Yanagisawa, T. & Nishimori, K., Jul 11 2003, In : European Journal of Pharmacology. 472, 3, p. 229-234 6 p.

Research output: Contribution to journalArticle

Myometrium
Vasopressins
Uterus
Oxytocin
Oxytocin Receptors
2002
112 Citations (Scopus)

Aplidin™ induces the mitochondrial apoptotic pathway via oxidative stress-mediated JNK and p38 activation and protein kinase C δ

García-Fernández, L. F., Losada, A., Alcaide, V., Álvarez, A. M., Cuadrado, A., González, L., Nakayama, K., Nakayama, K., Fernández-Sousa, J. M., Muñoz, A. & Sánchez-Puelles, J. M., Jan 1 2002, In : Oncogene. 21, 49, p. 7533-7544 12 p.

Research output: Contribution to journalArticle

p38 Mitogen-Activated Protein Kinases
Protein Kinase C
Protein Kinase C-delta
Oxidative Stress
Caspases
385 Citations (Scopus)

CHIP is associated with Parkin, a gene responsible for familial Parkinson's Disease, and enhances its ubiquitin ligase activity

Imai, Y., Soda, M., Hatakeyama, S., Akagi, T., Hashikawa, T., Nakayama, K. I. & Takahashi, R., Jan 1 2002, In : Molecular Cell. 10, 1, p. 55-67 13 p.

Research output: Contribution to journalArticle

Endoplasmic Reticulum Stress
Ubiquitination
Ligases
Ubiquitin
Parkinson Disease
195 Citations (Scopus)
S-Phase Kinase-Associated Proteins
Proteolysis
Stomach
Carcinoma
Phenotype
312 Citations (Scopus)

Clonal identification and characterization of self-renewing pluripotent stem cells in the developing liver

Suzuki, A., Zheng, Y. W., Kaneko, S., Onodera, M., Fukao, K., Nakauchi, H. & Taniguchi, H., Jan 7 2002, In : Journal of Cell Biology. 156, 1, p. 173-184 12 p.

Research output: Contribution to journalArticle

Pluripotent Stem Cells
Hepatocytes
Liver
Stem Cells
Digestive System Diseases
46 Citations (Scopus)

Cutting edge: Tyk2 is required for the induction and nuclear translocation of Daxx which regulates IFN-α-induced suppression of B lymphocyte formation

Shimoda, K., Kamesaki, K., Numata, A., Aoki, K., Matsuda, T., Oritani, K., Tamiya, S., Kato, K., Takase, K., Imamura, R., Yamamoto, T., Miyamoto, T., Nagafuji, K., Gondo, H., Nagafuchi, S., Nakayama, K. I. & Harada, M., Nov 1 2002, In : Journal of Immunology. 169, 9, p. 4707-4711 5 p.

Research output: Contribution to journalArticle

B-Lymphocytes
Interleukin-7
B-Lymphoid Precursor Cells
Nuclear Proteins
Up-Regulation
54 Citations (Scopus)

Diminished alcohol preference in transgenic mice lacking aldehyde dehydrogenase activity

Isse, T., Oyama, T., Kitagawa, K., Matsuno, K., Matsumoto, A., Yoshida, A., Nakayama, K., Nakayama, K. & Kawamoto, T., Nov 1 2002, In : Pharmacogenetics. 12, 8, p. 621-626 6 p.

Research output: Contribution to journalArticle

Aldehyde Dehydrogenase
Transgenic Mice
Alcohols
Acetaldehyde
Ethanol
24 Citations (Scopus)

Formation of Mallory body-like inclusions and cell death induced by deregulated expression of keratin 18

Nakamichi, I., Hatakeyama, S. & Nakayama, K. I., Oct 1 2002, In : Molecular biology of the cell. 13, 10, p. 3441-3451 11 p.

Research output: Contribution to journalArticle

Mallory Bodies
Keratin-18
Cell Death
Keratin-8
Griseofulvin
3 Citations (Scopus)

Functional analysis of oxytocin and oxytocin receptor with the genes deficient mice

Nishimori, K., Kawamata, M. & Takayanagi, Y., Jan 1 2002, In : Nippon Nogeikagaku Kaishi. 76, 11, p. 1086-1089 4 p.

Research output: Contribution to journalArticle

Posterior Pituitary Hormones
Oxytocin Receptors
oxytocin
Oxytocin
Reproduction
11 Citations (Scopus)

Glomerular differentiation in p27 and p57 double-mutant metanephroi

Tomari, S., Nagahama, H., Shu, Y., Hoshi, S., Nakayama, K., Nakayama, K. & Nagata, M., 2002, In : Anatomy and Embryology. 206, 1-2, p. 31-36 6 p.

Research output: Contribution to journalArticle

Podocytes
Organ Culture Techniques
Foot
Histology
Cell Cycle
329 Citations (Scopus)

Increased proliferation of B cells and auto-immunity in mice lacking protein kinase Cδ

Miyamoto, A., Nakayama, K., Imaki, H., Hirose, S., Jiang, Y., Abe, M., Tsukiyama, T., Nagahama, H., Ohno, S., Hatakeyama, S. & Nakayama, K. I., Apr 25 2002, In : Nature. 416, 6883, p. 865-869 5 p.

Research output: Contribution to journalArticle

Protein Kinase C
Immunity
B-Lymphocytes
CCAAT-Enhancer-Binding Protein-beta
Germinal Center
9 Citations (Scopus)

Isolation and characterization of a novel F-box protein Pof10 in fission yeast

Ikebe, C., Nakayama, K. I., Ikebe, C., Kominami, K. I., Nakayama, K. I., Kominami, K. I., Nakayama, K. I. & Toda, T., Jan 1 2002, In : Biochemical and Biophysical Research Communications. 290, 5, p. 1399-1407 9 p.

Research output: Contribution to journalArticle

F-Box Proteins
Schizosaccharomyces
Yeast
Two-Hybrid System Techniques
Ubiquitin-Protein Ligases
38 Citations (Scopus)

Modulation of astrocyte proliferation by cyclin-dependent kinase inhibitor p27Kip1

Koguchi, K., Nakatsuji, Y., Nakayama, K. & Sakoda, S., Mar 4 2002, In : GLIA. 37, 2, p. 93-104 12 p.

Research output: Contribution to journalArticle

Cyclin-Dependent Kinases
Astrocytes
Gliosis
Contact Inhibition
Cyclin A
56 Citations (Scopus)

Multiple Skp1-related proteins in Caenorhabditis elegans: Diverse patterns of interaction with Cullins and F-box proteins

Yamanaka, A., Yada, M., Imaki, H., Koga, M., Ohshima, Y. & Nakayama, K. I., Feb 19 2002, In : Current Biology. 12, 4, p. 267-275 9 p.

Research output: Contribution to journalArticle

S-Phase Kinase-Associated Proteins
Cullin Proteins
F-Box Proteins
F-box proteins
Caenorhabditis elegans
58 Citations (Scopus)

Partial impairment of interleukin-12 (IL-12) and IL-18 signaling in Tyk2-deficient mice

Shimoda, K., Tsutsui, H., Aoki, K., Kato, K., Matsuda, T., Numata, A., Takase, K., Yamamoto, T., Nukina, H., Hoshino, T., Asano, Y., Gondo, H., Okamura, T., Okamura, S., Nakayama, K. I., Nakanishi, K., Niho, Y. & Harada, M., Mar 15 2002, In : Blood. 99, 6, p. 2094-2099 6 p.

Research output: Contribution to journalArticle

Interleukin-18
Interleukin-12
Natural Killer Cells
Interferons
Interleukin-18 Receptors
229 Citations (Scopus)

Phosphorylation of p27Kip1 on serine 10 is required for its binding to CRM1 and nuclear export

Ishida, N., Hara, T., Kamura, T., Yoshida, M., Nakayama, K. & Nakayama, K., Apr 26 2002, In : Journal of Biological Chemistry. 277, 17, p. 14355-14358 4 p.

Research output: Contribution to journalArticle

Phosphorylation
Cell Nucleus Active Transport
Serine
SKP Cullin F-Box Protein Ligases
Substitution reactions
19 Citations (Scopus)

Polymorphism analysis of the upstream region of the human N-methyl-D-aspartate receptor subunit NR1 gene (GRIN1): Implications for schizophrenia

Tani, A., Kikuta, R., Itoh, K., Joo, A., Shibata, H., Ninomiya, H., Tashiro, N. & Fukumaki, Y., Nov 1 2002, In : Schizophrenia research. 58, 1, p. 83-86 4 p.

Research output: Contribution to journalArticle

N-Methyl-D-Aspartate Receptors
Schizophrenia
Single Nucleotide Polymorphism
Genes
Initiator Codon
54 Citations (Scopus)

Recovery of liver mass without proliferation of hepatocytes after partial hepatectomy in Skp2-deficient mice

Minamishima, Y. A., Nakayama, K. & Nakayama, K., 2002, In : Cancer Research. 62, 4, p. 995-999 5 p.

Research output: Contribution to journalArticle

Hepatectomy
Hepatocytes
Polyploidy
Cell Proliferation
Liver
108 Citations (Scopus)

Role of the PLC-related, catalytically inactive protein p130 in GABAA receptor function

Kanematsu, T., Jang, I. S., Yamaguchi, T., Nagahama, H., Yoshimura, K., Hidaka, K., Matsuda, M., Takeuchi, H., Misumi, Y., Nakayama, K., Yamamoto, T., Akaike, N., Hirata, M. & Nakayama, K., Mar 1 2002, In : EMBO Journal. 21, 5, p. 1004-1011 8 p.

Research output: Contribution to journalArticle

GABA-A Receptors
Programmable logic controllers
Proteins
Diazepam
gamma-Aminobutyric Acid
2001
30 Citations (Scopus)

Association study of polymorphisms in the GluR5 kainate receptor gene (GRIK1) with schizophrenia

Shibata, H., Joo, A., Fujii, Y., Tani, A., Makino, C., Hirata, N., Kikuta, R., Ninomiya, H., Tashiro, N. & Fukumaki, Y., Oct 30 2001, In : Psychiatric Genetics. 11, 3, p. 139-144 6 p.

Research output: Contribution to journalArticle

Single Nucleotide Polymorphism
Schizophrenia
Genes
Haplotypes
Polymerase Chain Reaction
21 Citations (Scopus)

Characterization of a mouse gene (Fbxw6) that encodes a homologue of Caenorhabditis elegans SEL-10

Maruyama, S. I., Hatakeyama, S., Nakayama, K., Ishida, N., Kawakami, K. & Nakayama, K. I., Sep 15 2001, In : Genomics. 78, 3, p. 214-222 9 p.

Research output: Contribution to journalArticle

Caenorhabditis elegans
F-Box Proteins
Presenilins
Genes
Proteins
28 Citations (Scopus)

Deafness due to degeneration of cochlear neurons in caspase-3-deficient mice

Morishita, H., Makishima, T., Kaneko, C., Lee, Y. S., Segil, N., Takahashi, K., Kuraoka, A., Nakagawa, T., Nabekura, J., Nakayama, K. & Nakayama, K. I., Jan 1 2001, In : Biochemical and Biophysical Research Communications. 284, 1, p. 142-149 8 p.

Research output: Contribution to journalArticle

Nerve Degeneration
Cochlea
Deafness
Caspase 3
Neurons
185 Citations (Scopus)

Degradation of p27Kip1 at the G0-G1 Transition Mediated by a Skp2-independent Ubiquitination Pathway

Hara, T., Kamura, T., Nakayama, K., Oshikawa, K., Hatakeyama, S. & Nakayama, K., Dec 28 2001, In : Journal of Biological Chemistry. 276, 52, p. 48937-48943 7 p.

Research output: Contribution to journalArticle

Ubiquitination
Cell Cycle
Cells
Proteolysis
Degradation
50 Citations (Scopus)

Down-regulation of p27Kip1 expression is required for development and function of T cells

Tsukiyama, T., Ishida, N., Shirane, M., Minamishima, Y. A., Hatakeyama, S., Kitagawa, M., Nakayama, K. & Nakayama, K. I., Jan 1 2001, In : Journal of Immunology. 166, 1, p. 304-312 9 p.

Research output: Contribution to journalArticle

Down-Regulation
T-Lymphocytes
Thymocytes
Cell Lineage
Transgenic Mice
91 Citations (Scopus)

Essential role of the prosurvival bcl-2 homologue A1 in mast cell survival after allergic activation

Xiang, Z., Ahmed, A. A., Möller, C., Nakayama, K. I., Hatakeyama, S. & Nilsson, G., Dec 3 2001, In : Journal of Experimental Medicine. 194, 11, p. 1561-1569 9 p.

Research output: Contribution to journalArticle

Mast Cells
Cell Survival
Hypersensitivity
p-Methoxy-N-methylphenethylamine
IgE Receptors
13 Citations (Scopus)

Hyperinsulinemia in PRIP-1 gene deleted mice

Doira, N., Kanematsu, T., Matsuda, M., Takeuchi, H., Nakano, H. O., Ito, Y., Nakayama, K., Nakayama, K. I. & Hirata, M., Jan 1 2001, In : Biomedical Research. 22, 3, p. 157-165 9 p.

Research output: Contribution to journalArticle

Hyperinsulinism
Programmable logic controllers
Genes
Type C Phospholipases
Protein Phosphatase 1
4 Citations (Scopus)

Morphologic and molecular analysis of estrogen-induced pituitary tumorigenesis in targeted disruption of transforming growth factor-β receptor type II and/or p27 mice

Ikeda, H., Yoshimoto, T., Shida, N., Miyoshi, I., Nakayama, K., Nakayama, K., Oshima, M. & Taketo, M. M., Jan 1 2001, In : Endocrine. 16, 1, p. 55-65 11 p.

Research output: Contribution to journalArticle

Growth Factor Receptors
Transforming Growth Factors
Estrogens
Carcinogenesis
Pituitary Gland
40 Citations (Scopus)

Regulation of the Level of Vesl-1S/Homer-1a Proteins by Ubiquitin-Proteasome Proteolytic Systems

Ageta, H., Kato, A., Hatakeyama, S., Nakayama, K., Isojima, Y. & Sugiyama, H., May 11 2001, In : Journal of Biological Chemistry. 276, 19, p. 15893-15897 5 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Ubiquitin
Proteasome Inhibitors
Proteins
Brain
82 Citations (Scopus)

Spatial and temporal expression patterns of the cyclin-dependent kinase (CDK) inhibitors p27Kip1 and p57Kip2 during mouse development

Nagahama, H., Hatakeyama, S., Nakayama, K., Nagata, M., Tomita, K. & Nakayama, K., Mar 19 2001, In : Anatomy and Embryology. 203, 2, p. 77-87 11 p.

Research output: Contribution to journalArticle

Cyclin-Dependent Kinases
Embryonic Development
Cyclin-Dependent Kinase Inhibitor p57
Phenotype
Palate