Department of Molecular and Cellular Biology

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Suppression of centrosome amplification after DNA damage depends on p27 accumulation

Sugihara, E., Kanai, M., Saito, S., Nitta, T., Toyoshima, H., Nakayama, K., Nakayama, K. I., Fukasawa, K., Schwab, M., Saya, H. & Miwa, M., Apr 15 2006, In : Cancer Research. 66, 8, p. 4020-4029 10 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

Suppression of lethal-7b and miR-125a/b Maturation by Lin28b Enables Maintenance of Stem Cell Properties in Hepatoblasts

Takashima, Y., Terada, M., Udono, M., Miura, S., Yamamoto, J. & Suzuki, A., Jul 1 2016, In : Hepatology. 64, 1, p. 245-260 16 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

T(8;21)(q22;q22) fusion proteins preferentially bind to duplicated AML1/RUNX1 DNA-binding sequences to differentially regulate gene expression

Okumura, A. J., Peterson, L. F., Okumura, F., Boyapati, A. & Zhang, D. E., Aug 15 2008, In : Blood. 112, 4, p. 1392-1401 10 p.

Research output: Contribution to journalArticle

Open Access
35 Citations (Scopus)

Targeted destruction of c-Myc by an engineered ubiquitin ligase suppresses cell transformation and tumor formation

Hatakeyama, S., Watanabe, M., Fujii, Y. & Nakayama, K. I., Sep 1 2005, In : Cancer Research. 65, 17, p. 7874-7879 6 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)

Targeted disruption of Skp2 results in accumulation of cyclin E and p27 (Kip1), polyploidy and centrosome overduplication

Nakayama, K., Nagahama, H., Minamishima, Y. A., Matsumoto, M., Nakamichi, I., Kitagawa, K., Shirane, M., Tsunematsu, R., Tsukiyama, T., Ishida, N., Kitagawa, M., Nakayama, K. I. & Hatakeyama, S., May 2 2000, In : EMBO Journal. 19, 9, p. 2069-2081 13 p.

Research output: Contribution to journalArticle

594 Citations (Scopus)

Targeting the p27 E3 ligase SCF Skp2 results in p27and Skp2-mediated cell-cycle arrest and activation of autophagy

Chen, Q., Xie, W., Kuhn, D. J., Voorhees, P. M., Lopez-Girona, A., Mendy, D., Corral, L. G., Krenitsky, V. P., Xu, W., Parseval, L. M. D., Webb, D. R., Mercurio, F., Nakayama, K. I., Nakayama, K. & Orlowski, R. Z., May 1 2008, In : Blood. 111, 9, p. 4690-4699 10 p.

Research output: Contribution to journalArticle

165 Citations (Scopus)

T-B cell interaction inhibits spontaneous apoptosis of mature lymphocytes in Bcl-2-deficient mice

Nakayama, K. I., Nakayama, K., Dustin, L. B. & Loh, D. Y., Oct 1 1995, In : Journal of Experimental Medicine. 182, 4, p. 1101-1110 10 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)

Tbx3 controls the fate of hepatic progenitor cells in liver development by suppressing p19ARF expression

Suzuki, A., Sekiya, S., Büscher, D., Belmonte, J. C. I. & Taniguchi, H., May 1 2008, In : Development. 135, 9, p. 1589-1595 7 p.

Research output: Contribution to journalArticle

83 Citations (Scopus)

The amelioration of renal damage in Skp2-deficient mice canceled by p27Kip1 deficiency in Skp2-/- p27-/- mice

Suzuki, S., Fukasawa, H., Misaki, T., Togawa, A., Ohashi, N., Kitagawa, K., Kotake, Y., Liu, N., Niida, H., Nakayama, K., Nakayama, K. I., Yamamoto, T. & Kitagawa, M., Apr 27 2012, In : PloS one. 7, 4, e36249.

Research output: Contribution to journalArticle

13 Citations (Scopus)

The Autism-Related Protein CHD8 Cooperates with C/EBPβ to Regulate Adipogenesis

Kita, Y., Katayama, Y., Shiraishi, T., Oka, T., Sato, T., Suyama, M., Ohkawa, Y., Miyata, K., Oike, Y., Shirane, M., Nishiyama, M. & Nakayama, K. I., May 15 2018, In : Cell Reports. 23, 7, p. 1988-2000 13 p.

Research output: Contribution to journalArticle

The cyclin-dependent kinase inhibitors p57 and p27 regulate neuronal migration in the developing mouse neocortex

Itoh, Y., Masuyama, N., Nakayama, K., Nakayama, K. I. & Gotoh, Y., Jan 5 2007, In : Journal of Biological Chemistry. 282, 1, p. 390-396 7 p.

Research output: Contribution to journalArticle

70 Citations (Scopus)

The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells

Paolino, M., Choidas, A., Wallner, S., Pranjic, B., Uribesalgo, I., Loeser, S., Jamieson, A. M., Langdon, W. Y., Ikeda, F., Fededa, J. P., Cronin, S. J., Nitsch, R., Schultz-Fademrecht, C., Eickhoff, J., Menninger, S., Unger, A., Torka, R., Gruber, T., Hinterleitner, R., Baier, G. & 4 others, Wolf, D., Ullrich, A., Klebl, B. M. & Penninger, J. M., Jan 1 2014, In : Nature. 507, 7493, p. 508-512 5 p.

Research output: Contribution to journalArticle

196 Citations (Scopus)

The F-box protein Skp2 participates in c-Myc proteosomal degradation and acts as a cofactor for c-Myc-regulated transcription

Von Der Lehr, N., Johansson, S., Wu, S., Bahram, F., Castell, A., Cetinkaya, C., Hydbring, P., Weidung, I., Nakayama, K., Nakayama, K. I., Söderberg, O., Kerppola, T. K. & Larsson, L. G., May 1 2003, In : Molecular Cell. 11, 5, p. 1189-1200 12 p.

Research output: Contribution to journalArticle

357 Citations (Scopus)

The F box protein S phase kinase-associated protein 2 regulates adipose mass and adipocyte number in vivo

Cooke, P. S., Holsberger, D. R., Cimafranca, M. A., Meling, D. D., Beals, C. M., Nakayama, K., Nakayama, K. I. & Kiyokawa, H., Jun 1 2007, In : Obesity. 15, 6, p. 1400-1408 9 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

The FBXL5-IRP2 axis is integral to control of iron metabolism in vivo

Moroishi, T., Nishiyama, M., Takeda, Y., Iwai, K. & Nakayama, K. I., Sep 7 2011, In : Cell metabolism. 14, 3, p. 339-351 13 p.

Research output: Contribution to journalArticle

73 Citations (Scopus)

The ISG15 isopeptidase UBP43 is regulated by proteolysis via the SCF Skp2 ubiquitin ligase

Tokarz, S., Berset, C., La Rue, J., Friedman, K., Nakayama, K. I., Nakayama, K., Zhang, D. E. & Lanker, S., Nov 5 2004, In : Journal of Biological Chemistry. 279, 45, p. 46424-46430 7 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

The novel heart-specific RING finger protein 207 is involved in energy metabolism in cardiomyocytes

Mizushima, W., Takahashi, H., Watanabe, M., Kinugawa, S., Matsushima, S., Takada, S., Yokota, T., Furihata, T., Matsumoto, J., Tsuda, M., Chiba, I., Nagashima, S., Yanagi, S., Matsumoto, M., Nakayama, K. I., Tsutsui, H. & Hatakeyama, S., Nov 1 2016, In : Journal of Molecular and Cellular Cardiology. 100, p. 43-53 11 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

The Papillomavirus E7 Oncoprotein Is Ubiquitinated by UbcH7 and Cullin 1- and Skp2-Containing E3 Ligase

Oh, K. J., Kalinina, A., Wang, J., Nakayama, K., Nakayama, K. I. & Bagchi, S., May 1 2004, In : Journal of virology. 78, 10, p. 5338-5346 9 p.

Research output: Contribution to journalArticle

60 Citations (Scopus)

The Parkin-coregulated gene product PACRG promotes TNF signaling by stabilizing LUBAC

Meschede, J., Šadić, M., Furthmann, N., Miedema, T., Sehr, D. A., Müller-Rischart, A. K., Bader, V., Berlemann, L. A., Pilsl, A., Schlierf, A., Barkovits, K., Kachholz, B., Rittinger, K., Ikeda, F., Marcus, K., Schaefer, L., Tatzelt, J. & Winklhofer, K. F., Feb 4 2020, In : Science Signaling. 13, 617, eaav1256.

Research output: Contribution to journalArticle

The pathophysiologic role of the protein kinase Cδ pathway in the intervertebral discs of rabbits and mice: In vitro, ex vivo, and in vivo studies

Ellman, M. B., Kim, J. S., An, H. S., Kroin, J. S., Li, X., Chen, D., Yan, D., Buechter, D. D., Nakayama, K., Liu, B., Morgan, S. & Im, H. J., Jun 1 2012, In : Arthritis and rheumatism. 64, 6, p. 1950-1959 10 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

The pericentromeric protein shugoshin 2 cooperates with HSF1 in heat shock response and RNA Pol II recruitment

Takii, R., Fujimoto, M., Matsumoto, M., Srivastava, P., Katiyar, A., Nakayama, K. I. & Nakai, A., Dec 16 2019, In : EMBO Journal. 38, 24, e102566.

Research output: Contribution to journalArticle

1 Citation (Scopus)

The reduction of cell death and proliferation by p27 Kip1 minimizes DNA damage in an experimental model of genotoxicity

Ranchal, I., González, R., Bello, R. I., Ferrín, G., Hidalgo, A. B., Linares, C. I., Aguilar-Melero, P., González-Rubio, S., Barrera, P., Marchal, T., Nakayama, K. I., De La Mata, M. & Muntané, J., Nov 15 2009, In : International Journal of Cancer. 125, 10, p. 2270-2280 11 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

The role of β-TrCP1 and β-TrCP2 in circadian rhythm generation by mediating degradation of clock protein PER2

Ohsaki, K., Oishi, K., Kozono, Y., Nakayama, K., Nakayama, K. & Ishida, N., Nov 1 2008, In : Journal of biochemistry. 144, 5, p. 609-618 10 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

The SCFβ-TRCP E3 ubiquitin ligase complex targets Lipin1 for ubiquitination and degradation to promote hepatic lipogenesis

Shimizu, K., Fukushima, H., Ogura, K., Lien, E. C., Nihira, N. T., Zhang, J., North, B. J., Guo, A., Nagashima, K., Nakagawa, T., Hoshikawa, S., Watahiki, A., Okabe, K., Yamada, A., Toker, A., Asara, J. M., Fukumoto, S., Nakayama, K. I., Nakayama, K., Inuzuka, H. & 1 others, Wei, W., Jan 3 2017, In : Science Signaling. 10, 460

Research output: Contribution to journalArticle

16 Citations (Scopus)

The second phase activation of protein kinase C δ at late G1 is required for DNA synthesis in serum-induced cell cycle progression

Kitamura, K., Mizuno, K., Etoh, A., Akita, Y., Miyamoto, A., Nakayama, K. & Ohno, S., Apr 1 2003, In : Genes to Cells. 8, 4, p. 311-324 14 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

The SKP2 E3 ligase regulates basal homeostasis and stress-induced regeneration of HSCs

Rodriguez, S., Wang, L., Mumaw, C., Srour, E. F., Lo Celso, C., Nakayama, K. I. & Carlesso, N., Jun 16 2011, In : Blood. 117, 24, p. 6509-6519 11 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

The Skp2-SCF E3 ligase regulates akt ubiquitination, glycolysis, herceptin sensitivity, and tumorigenesis

Chan, C. H., Li, C. F., Yang, W. L., Gao, Y., Lee, S. W., Feng, Z., Huang, H. Y., Tsai, K. K. C., Flores, L. G., Shao, Y., Hazle, J. D., Yu, D., Wei, W., Sarbassov, D., Hung, M. C., Nakayama, K. I. & Lin, H. K., May 25 2012, In : Cell. 149, 5, p. 1098-1111 14 p.

Research output: Contribution to journalArticle

201 Citations (Scopus)

The SOCS Box of SOCS-1 Accelerates Ubiquitin-dependent Proteolysis of TEL-JAK2

Kamizono, S., Hanada, T., Yasukawa, H., Minoguchi, S., Kato, R., Minoguchi, M., Hattori, K., Hatakeyama, S., Yada, M., Morita, S., Kitamura, T., Kato, H., Nakayama, K. I. & Yoshimura, A., Apr 20 2001, In : Journal of Biological Chemistry. 276, 16, p. 12530-12538 9 p.

Research output: Contribution to journalArticle

248 Citations (Scopus)

The Tumor Suppressor Hace1 Is a Critical Regulator of TNFR1-Mediated Cell Fate

Tortola, L., Nitsch, R., Bertrand, M. J. M., Kogler, M., Redouane, Y., Kozieradzki, I., Uribesalgo, I., Fennell, L. M., Daugaard, M., Klug, H., Wirnsberger, G., Wimmer, R., Perlot, T., Sarao, R., Rao, S., Hanada, T., Takahashi, N., Kernbauer, E., Demiröz, D., Superti-Furga, G. & 7 others, Decker, T., Pichler, A., Ikeda, F., Kroemer, G., Vandenabeele, P., Sorensen, P. H. & Penninger, J. M., May 17 2016, In : Cell Reports. 15, 7, p. 1481-1492 12 p.

Research output: Contribution to journalArticle

Open Access
15 Citations (Scopus)
19 Citations (Scopus)

TMEM55B contributes to lysosomal homeostasis and amino acid–induced mTORC1 activation

Hashimoto, Y., Shirane, M. & Nakayama, K. I., Jun 2018, In : Genes to Cells. 23, 6, p. 418-434 17 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Transcriptional up-regulation of MMP12 and MMP13 by asbestos occurs via a PKCδ-dependent pathway in murine lung

Shukla, A., Barrett, T. F., Nakayama, K., Nakayama, K., Mossman, B. T. & Lounsbury, K. M., May 2006, In : FASEB Journal. 20, 7

Research output: Contribution to journalArticle

34 Citations (Scopus)

Transcription Factor PU.1 Represses and Activates Gene Expression in Early T Cells by Redirecting Partner Transcription Factor Binding

Hosokawa, H., Ungerbäck, J., Wang, X., Matsumoto, M., Nakayama, K. I., Cohen, S. M., Tanaka, T. & Rothenberg, E. V., Jun 19 2018, In : Immunity. 48, 6, p. 1119-1134.e7

Research output: Contribution to journalArticle

19 Citations (Scopus)

Transcription factors interfering with dedifferentiation induce cell type-specific transcriptional profiles

Hikichi, T., Matoba, R., Ikeda, T., Watanabe, A., Yamamoto, T., Yoshitake, S., Tamura-Nakano, M., Kimura, T., Kamon, M., Shimura, M., Kawakami, K., Okuda, A., Okochi, H., Inoue, T., Suzuki, A. & Masui, S., Apr 16 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 16, p. 6412-6417 6 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Trans-omic Analysis Reveals Selective Responses to Induced and Basal Insulin across Signaling, Transcriptional, and Metabolic Networks

Kawata, K., Hatano, A., Yugi, K., Sano, T., Fujii, M., Tomizawa, Y., Kokaji, T., Tanaka, K. Y., Uda, S., Suzuki, Y., Matsumoto, M., Nakayama, K., Saitoh, K., Kato, K., Ueno, A., Ohishi, M., Hirayama, A., Soga, T. & Kuroda, S., 2018, In : iScience. 7, p. 212-229

Research output: Contribution to journalArticle

Trans-omic Analysis Reveals Selective Responses to Induced and Basal Insulin across Signaling, Transcriptional, and Metabolic Networks

Kawata, K., Hatano, A., Yugi, K., Kubota, H., Sano, T., Fujii, M., Tomizawa, Y., Kokaji, T., Tanaka, K. Y., Uda, S., Suzuki, Y., Matsumoto, M., Nakayama, K. I., Saitoh, K., Kato, K., Ueno, A., Ohishi, M., Hirayama, A., Soga, T. & Kuroda, S., Sep 28 2018, In : iScience. 7, p. 212-229 18 p.

Research output: Contribution to journalArticle

Open Access
7 Citations (Scopus)

TRIM8 modulates STAT3 activity through negative regulation of PIAS3

Okumura, F., Matsunaga, Y., Katayama, Y., Nakayama, K. I. & Hatakeyama, S., Jul 1 2010, In : Journal of Cell Science. 123, 13, p. 2238-2245 8 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)

TRIM8 regulates Nanog via Hsp90β-mediated nuclear translocation of STAT3 in embryonic stem cells

Okumura, F., Okumura, A. J., Matsumoto, M., Nakayama, K. I. & Hatakeyama, S., Oct 1 2011, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1813, 10, p. 1784-1792 9 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Truncation mutants of ASXL1 observed in myeloid malignancies are expressed at detectable protein levels

Inoue, D., Matsumoto, M., Nagase, R., Saika, M., Fujino, T., Nakayama, K. I. & Kitamura, T., Mar 1 2016, In : Experimental Hematology. 44, 3, p. 172-176.e1

Research output: Contribution to journalArticle

24 Citations (Scopus)

Two distinct knockout approaches highlight a critical role for p53 in rat development

Kawamata, M. & Ochiya, T., Dec 1 2012, In : Scientific reports. 2, 945.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis

Nishitani, H., Sugimoto, N., Roukos, V., Nakanishi, Y., Saijo, M., Obuse, C., Tsurimoto, T., Nakayama, K. I., Nakayama, K., Fujita, M., Lygerou, Z. & Nishimoto, T., Mar 8 2006, In : EMBO Journal. 25, 5, p. 1126-1136 11 p.

Research output: Contribution to journalArticle

279 Citations (Scopus)

Two inhibitory systems and CKIs regulate cell cycle exit of mammalian cardiomyocytes after birth

Tane, S., Okayama, H., Ikenishi, A., Amemiya, Y., Nakayama, K. & Takeuchi, T., Oct 16 2015, In : Biochemical and Biophysical Research Communications. 466, 2, p. 147-154 8 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Tyk2-dependent bystander activation of conventional and nonconventional Th1 cell subsets contributes to innate host defense against listeria monocytogenes infection

Hashiguchi, T., Oyamada, A., Sakuraba, K., Shimoda, K., Nakayama, K. I., Iwamoto, Y., Yoshikai, Y. & Yamada, H., May 15 2014, In : Journal of Immunology. 192, 10, p. 4739-4747 9 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Tyk2 is essential for IFN-α-induced gene expression in mast cells

Mori, Y., Hirose, K., Suzuki, K., Nakajima, H., Seto, Y., Ikeda, K., Shimoda, K., Nakayama, K. I., Saito, Y. & Iwamoto, I., Jun 15 2004, In : International Archives of Allergy and Immunology. 134, SUPPL. 1, p. 25-29 5 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Tyk2 plays a restricted role in IFNα signaling, although it is required for IL-12-mediated T cell function

Shimoda, K., Kato, K., Aoki, K., Matsuda, T., Miyamoto, A., Shibamori, M., Yamashita, M., Numata, A., Takase, K., Kobayashi, S., Shibata, S., Asano, Y., Gondo, H., Sekiguchi, K., Nakayama, K., Nakayama, T., Okamura, T., Okamura, S., Niho, Y. & Nakayama, K. I., Jan 1 2000, In : Immunity. 13, 4, p. 561-571 11 p.

Research output: Contribution to journalArticle

238 Citations (Scopus)

Tyk2 signaling in host environment plays an important role in contraction of antigen-specific CD8+ T cells following a microbial infection

Li, W., Yamada, H., Yajima, T., Nakagawa, R., Shimoda, K., Nakayama, K. & Yoshikai, Y., Apr 1 2007, In : Journal of Immunology. 178, 7, p. 4482-4488 7 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Tyk2-signaling plays an important role in host defense against Escherichia coli through IL-23-induced IL-17 production by γδ T cells

Nakamura, R., Shibata, K., Yamada, H., Shimoda, K., Nakayama, K. & Yoshikai, Y., Aug 1 2008, In : Journal of Immunology. 181, 3, p. 2071-2075 5 p.

Research output: Contribution to journalArticle

49 Citations (Scopus)

Tyrosine kinase 2 plays critical roles in the pathogenic CD4 T cell responses for the development of experimental autoimmune encephalomyelitis

Oyamada, A., Ikebe, H., Itsumi, M., Saiwai, H., Okada, S., Shimoda, K., Iwakura, Y., Nakayama, K. I., Iwamoto, Y., Yoshikai, Y. & Yamada, H., Dec 1 2009, In : Journal of Immunology. 183, 11, p. 7539-7546 8 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

UBE4B promotes Hdm2-mediated degradation of the tumor suppressor p53

Wu, H., Pomeroy, S. L., Ferreira, M., Teider, N., Mariani, J., Nakayama, K. I., Hatakeyama, S., Tron, V. A., Saltibus, L. F., Spyracopoulos, L. & Leng, R. P., Mar 1 2011, In : Nature medicine. 17, 3, p. 347-355 9 p.

Research output: Contribution to journalArticle

64 Citations (Scopus)

Ubiquitin-dependent degradation of IκBα is mediated by a ubiquitin ligase Skp1/Cul 1/F-box protein FWD1

Hatakeyama, S., Kitagawa, M., Nakayama, K., Shirane, M., Matsumoto, M., Hattori, K., Higashi, H., Nakano, H., Okumura, K., Onoé, K., Good, R. A. & Nakayama, K. I., Mar 30 1999, In : Proceedings of the National Academy of Sciences of the United States of America. 96, 7, p. 3859-3863 5 p.

Research output: Contribution to journalArticle

168 Citations (Scopus)