Department of Stem Cell Biology and Medicine

Research Output 1992 2019

2019

CCR6+ group 3 innate lymphoid cells accumulate in inflamed joints in rheumatoid arthritis and produce Th17 cytokines

Takaki-Kuwahara, A., Arinobu, Y., Miyawaki, K., Yamada, H., Tsuzuki, H., Irino, K., Ayano, M., Kimoto, Y., Mitoma, H., Akahoshi, M., Tsukamoto, H., Horiuchi, T., Niiro, H. & Akashi, K., Aug 30 2019, In : Arthritis Research and Therapy. 21, 1, 198.

Research output: Contribution to journalArticle

Open Access
Rheumatoid Arthritis
Joints
Lymphocytes
Cytokines
Synovial Fluid
Phase II Clinical Trials
Clinical Trials, Phase I
Systemic Scleroderma
Hematopoietic Stem Cell Transplantation
Japan
9 Citations (Scopus)

Cell-based screen identifies a new potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth

Oshima, T., Niwa, Y., Kuwata, K., Srivastava, A., Hyoda, T., Tsuchiya, Y., Kumagai, M., Tsuyuguchi, M., Tamaru, T., Sugiyama, A., Ono, N., Zolboot, N., Aikawa, Y., Oishi, S., Nonami, A., Arai, F., Hagihara, S., Yamaguchi, J., Tama, F., Kunisaki, Y. & 6 others, Yagita, K., Ikeda, M., Kinoshita, T., Kay, S. A., Itami, K. & Hirota, T., Jan 23 2019, In : Science Advances. 5, 1, eaau9060.

Research output: Contribution to journalArticle

Open Access
Circadian Rhythm
Circadian Clocks
Phosphotransferases
Growth
Neoplasms
Open Access
Metagenome
Bacterial Genomes
Base Composition
Libraries
Metagenomics

Early-life exposure to low levels of permethrin exerts impairments in learning and memory with the effects on neuronal and glial population in adult male mice

Saito, H., Hara, K., Tominaga, T., Nakashima, K. & Tanemura, K., Dec 1 2019, In : Journal of Applied Toxicology. 39, 12, p. 1651-1662 12 p.

Research output: Contribution to journalArticle

Permethrin
Neuroglia
Learning
Data storage equipment
Population

Enhanced processivity of Dnmt1 by monoubiquitinated histone H3

Mishima, Y., Brueckner, L., Takahashi, S., Kawakami, T., Otani, J., Shinohara, A., Takeshita, K., Garvilles, R. G., Watanabe, M., Sakai, N., Takeshima, H., Nachtegael, C., Nishiyama, A., Nakanishi, M., Arita, K., Nakashima, K., Hojo, H. & Suetake, I., Jan 1 2019, (Accepted/In press) In : Genes to Cells.

Research output: Contribution to journalArticle

Histones
Ubiquitination
Methyltransferases
DNA Methylation
DNA

Environmental Optimization Enables Maintenance of Quiescent Hematopoietic Stem Cells Ex Vivo

Kobayashi, H., Morikawa, T., Okinaga, A., Hamano, F., Hashidate-Yoshida, T., Watanuki, S., Hishikawa, D., Shindou, H., Arai, F., Kabe, Y., Suematsu, M., Shimizu, T. & Takubo, K., Jul 2 2019, In : Cell Reports. 28, 1, p. 145-158.e9

Research output: Contribution to journalArticle

Open Access
Hematopoietic Stem Cells
Stem cells
Maintenance
Fatty Acids
Cell culture
1 Citation (Scopus)
Mesentery
Epithelial-Mesenchymal Transition
Gonads
Morphogenesis
Ovary
1 Citation (Scopus)

Evaluation of SNP calling methods for closely related bacterial isolates and a novel high-accuracy pipeline: BactSNP

Yoshimura, D., Kajitani, R., Gotoh, Y., Katahira, K., Okuno, M., Ogura, Y., Hayashi, T. & Itoh, T., May 1 2019, In : Microbial Genomics. 5, 5

Research output: Contribution to journalArticle

Open Access
Single Nucleotide Polymorphism
Genome
Benchmarking
Disease Outbreaks
Bacteria

Generation of Nanog reporter mice that distinguish pluripotent stem cells from unipotent primordial germ cells

Terada, M., Kawamata, M., Kimura, R., Sekiya, S., Nagamatsu, G., Hayashi, K., Horisawa, K. & Suzuki, A., Nov 1 2019, In : Genesis. 57, 11-12, e23334.

Research output: Contribution to journalArticle

Pluripotent Stem Cells
Germ Cells
Embryonic Stem Cells
Genetic Promoter Regions
Transgenic Mice

Genome sequencing verifies relapsed infection of helicobacter cinaedi

Sawada, O., Gotoh, Y., Taniguchi, T., Furukawa, S., Yoshimura, D., Sasaki, S., Shida, H., Kusunoki, Y., Yamamura, T., Furuya, K., Itoh, T., Horita, T., Hayashi, T. & Misawa, N., Jan 1 2019, In : Open Forum Infectious Diseases. 6, 5

Research output: Contribution to journalArticle

Open Access
Helicobacter Infections
Genome
Infection
Single Nucleotide Polymorphism
Clone Cells
Neural Stem Cells
Astrocytes
Epigenomics
Central Nervous System
Multipotent Stem Cells
1 Citation (Scopus)

Hypoxia induces the dormant state in oocytes through expression of Foxo3

Shimamoto, S., Nishimura, Y., Nagamatsu, G., Hamada, N., Kita, H., Hikabe, O., Hamazaki, N. & Hayashi, K., Jun 18 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 25, p. 12321-12326 6 p.

Research output: Contribution to journalArticle

Oocytes
Reproductive Medicine
Oogenesis
Transcriptome
Mammals

In vitro reconstitution of germ cell development

Hayashi, K., Sep 1 2019, In : Biology of Reproduction. 101, 3, p. 567-578 12 p.

Research output: Contribution to journalReview article

Gametogenesis
Pluripotent Stem Cells
Germ Cells
Oocytes
Spermatozoa

Lack of whey acidic protein (WAP) four-disulfide core domain protease inhibitor 2 (WFDC2) causes neonatal death from respiratory failure in mice

Nakajima, K., Ono, M., Radovic, U. S., Dizdarevic, S., Tomizawa, S. I., Kuroha, K., Nagamatsu, G., Hoshi, I., Matsunaga, R., Shirakawa, T., Kurosawa, T., Miyazaki, Y., Seki, A., Suzuki, Y., Koseki, H., Nakamura, M., Suda, T. & Ohbo, K., Jan 1 2019, In : DMM Disease Models and Mechanisms. 12, 11, dmm.040139.

Research output: Contribution to journalArticle

Open Access
Protease Inhibitors
Respiratory Insufficiency
Disulfides
Cause of Death
Lung

Large-scale genome analysis of bovine commensal Escherichia coli reveals that bovine-adapted E. Coli lineages are serving as evolutionary sources of the emergence of human intestinal pathogenic strains

Arimizu, Y., Kirino, Y., Sato, M. P., Uno, K., Sato, T., Gotoh, Y., Auvray, F., Brugere, H., Oswald, E., Mainil, J. G., Anklam, K. S., Döpfer, D., Yoshino, S., Ooka, T., Tanizawa, Y., Nakamura, Y., Iguchi, A., Morita-Ishihara, T., Ohnishi, M., Akashi, K. & 2 others, Hayashi, T. & Ogura, Y., Jan 1 2019, In : Genome Research. 29, 9, p. 1495-1505 11 p.

Research output: Contribution to journalArticle

Open Access
Enteropathogenic Escherichia coli
Genome
Escherichia coli
Virulence
Enterocytes
4 Citations (Scopus)

Mechanical stress accompanied with nuclear rotation is involved in the dormant state of mouse oocytes

Nagamatsu, G., Shimamoto, S., Hamazaki, N., Nishimura, Y. & Hayashi, K., Jan 1 2019, In : Science Advances. 5, 6, eaav9960.

Research output: Contribution to journalArticle

Open Access
gametocytes
mice
ovaries
boxes
activation
2 Citations (Scopus)

Multi-step genomic dissection of a suspected intra-hospital helicobacter cinaedi outbreak

Gotoh, Y., Taniguchi, T., Yoshimura, D., Katsura, K., Saeki, Y., Hirabara, Y., Fukuda, M., Takajo, I., Tomida, J., Kawamura, Y., Ogura, Y., Itoh, T., Misawa, N., Okayama, A. & Hayashi, T., Jan 2019, In : Microbial Genomics. 5, 1, 000236.

Research output: Contribution to journalArticle

Helicobacter
Disease Outbreaks
Dissection
Genome
Bacteremia

Nox4 Promotes Neural Stem/Precursor Cell Proliferation and Neurogenesis in the Hippocampus and Restores Memory Function Following Trimethyltin-Induced Injury

Yoshikawa, Y., Ago, T., Kuroda, J., Wakisaka, Y., Tachibana, M., Komori, M., Shibahara, T., Nakashima, H., Nakashima, K. & Kitazono, T., Feb 1 2019, In : Neuroscience. 398, p. 193-205 13 p.

Research output: Contribution to journalArticle

Neural Stem Cells
Neurogenesis
Hippocampus
Cell Proliferation
Wounds and Injuries

Np95/Uhrf1 regulates tumor suppressor gene expression of neural stem/precursor cells, contributing to neurogenesis in the adult mouse brain

Murao, N., Matsubara, S., Matsuda, T., Noguchi, H., Mutoh, T., Mutoh, M., Koseki, H., Namihira, M. & Nakashima, K., Jun 2019, In : Neuroscience Research. 143, p. 31-43 13 p.

Research output: Contribution to journalArticle

Neural Stem Cells
Neurogenesis
Tumor Suppressor Genes
Gene Expression
Brain

O-antigen biosynthesis gene clusters of Escherichia albertii: Their diversity and similarity to Escherichia coli gene clusters and the development of an o-genotyping method

Ooka, T., Seto, K., Ogura, Y., Nakamura, K., Iguchi, A., Gotoh, Y., Honda, M., Etoh, Y., Ikeda, T., Sugitani, W., Konno, T., Kawano, K., Imuta, N., Yoshiie, K., Hara-Kudo, Y., Murakami, K., Hayashi, T. & Nishi, J., Jan 1 2019, In : Microbial Genomics. 5, 11, 000314.

Research output: Contribution to journalArticle

Open Access
Escherichia
O Antigens
Multigene Family
Escherichia coli
Genotype
11 Citations (Scopus)

Pioneer Factor NeuroD1 Rearranges Transcriptional and Epigenetic Profiles to Execute Microglia-Neuron Conversion

Matsuda, T., Irie, T., Katsurabayashi, S., Hayashi, Y., Nagai, T., Hamazaki, N., Adefuin, A. M. D., Miura, F., Ito, T., Kimura, H., Shirahige, K., Takeda, T., Iwasaki, K., Imamura, T. & Nakashima, K., Feb 6 2019, In : Neuron. 101, 3, p. 472-485.e7

Research output: Contribution to journalArticle

Microglia
Epigenomics
Neurons
Transcription Factors
Genes
2 Citations (Scopus)

Regnase-1-mediated post-transcriptional regulation is essential for hematopoietic stem and progenitor cell homeostasis

Kidoya, H., Muramatsu, F., Shimamura, T., Jia, W., Satoh, T., Hayashi, Y., Naito, H., Kunisaki, Y., Arai, F., Seki, M., Suzuki, Y., Osawa, T., Akira, S. & Takakura, N., Dec 1 2019, In : Nature communications. 10, 1, 1072.

Research output: Contribution to journalArticle

Open Access
homeostasis
stem cells
Hematopoietic Stem Cells
Homeostasis
hematopoiesis

Stem Cell-Derived Human Gametes: The Public Engagement Imperative

Adashi, E. Y., Cohen, I. G., Hanna, J. H., Surani, A. M. & Hayashi, K., Mar 2019, In : Trends in Molecular Medicine. 25, 3, p. 165-167 3 p.

Research output: Contribution to journalShort survey

Germ Cells
Stem Cells
Technology
3 Citations (Scopus)

Suppressor of fused controls perinatal expansion and quiescence of future dentate adult neural stem cells

Noguchi, H., Castillo, J. G., Nakashima, K. & Pleasure, S. J., Apr 11 2019, In : eLife. 8, e42918.

Research output: Contribution to journalArticle

Open Access
Adult Stem Cells
Neural Stem Cells
Stem cells
Hedgehogs
Dentate Gyrus
1 Citation (Scopus)

The earth is small for “leviathans”: Long distance dispersal of giant viruses across aquatic environments

Li, Y., Endo, H., Gotoh, Y., Watai, H., Ogawa, N., Blanc-Mathieu, R., Yoshida, T. & Ogata, H., Jan 1 2019, In : Microbes and Environments. 34, 3, p. 334-339 6 p.

Research output: Contribution to journalArticle

Open Access
Otus
aquatic environment
virus
viruses
hot springs
1 Citation (Scopus)

Therapeutic time window of anti-high mobility group box-1 antibody administration in mouse model of spinal cord injury

Nakajo, M., Uezono, N., Nakashima, H., Wake, H., Komiya, S., Nishibori, M. & Nakashima, K., Apr 2019, In : Neuroscience Research. 141, p. 63-70 8 p.

Research output: Contribution to journalArticle

Spinal Cord Injuries
Antibodies
Injections
Monoclonal Antibodies
Therapeutics
2018
3 Citations (Scopus)

Canonical TGF-β signaling negatively regulates neuronal morphogenesis through TGIF/Smad complex-mediated CRMP2 suppression

Nakashima, H., Tsujimura, K., Irie, K., Ishizu, M., Pan, M., Kameda, T. & Nakashima, K., May 16 2018, In : Journal of Neuroscience. 38, 20, p. 4791-4810 20 p.

Research output: Contribution to journalArticle

Transforming Growth Factors
Morphogenesis
Neurons
Cytokines
Induced Pluripotent Stem Cells

Current advance of in vitro gametogenesis

Hayashi, K., Jan 1 2018, In : Seikagaku. 90, 4, p. 533-538 6 p.

Research output: Contribution to journalReview article

Gametogenesis
In Vitro Techniques
5 Citations (Scopus)
Neurogenesis
Valproic Acid
Anticonvulsants
Seizures
Neural Stem Cells
5 Citations (Scopus)
glycohemoglobin
rheumatoid arthritis
tumor necrosis factors
Glycosylated Hemoglobin A
observational studies
11 Citations (Scopus)

Embryos and embryonic stem cells from the white rhinoceros

Hildebrandt, T. B., Hermes, R., Colleoni, S., Diecke, S., Holtze, S., Renfree, M. B., Stejskal, J., Hayashi, K., Drukker, M., Loi, P., Göritz, F., Lazzari, G. & Galli, C., Dec 1 2018, In : Nature communications. 9, 1, 2589.

Research output: Contribution to journalArticle

gametocytes
Mammals
stem cells
embryos
Blastocyst

Epigenetic Regulation of Human Neural Stem Cell Differentiation

Honda, M., Nakashima, K. & Katada, S., Jan 1 2018, Results and Problems in Cell Differentiation. Springer Verlag, p. 125-136 12 p. (Results and Problems in Cell Differentiation; vol. 66).

Research output: Chapter in Book/Report/Conference proceedingChapter

Neural Stem Cells
Epigenomics
Cell Differentiation
Histone Code
Induced Pluripotent Stem Cells
6 Citations (Scopus)

Epigenetic regulation of neural stem cell differentiation towards spinal cord regeneration

Kameda, T., Imamura, T. & Nakashima, K., Jan 1 2018, In : Cell and tissue research. 371, 1, p. 189-199 11 p.

Research output: Contribution to journalReview article

Spinal Cord Regeneration
Neural Stem Cells
Epigenomics
Cell Differentiation
Spinal Cord Injuries
15 Citations (Scopus)

Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS

yamauchi, T., Masuda, T., Canver, M. C., Seiler, M., Semba, Y., Shboul, M., Al-Raqad, M., Maeda, M., Schoonenberg, V. A. C., Cole, M. A., Macias-Trevino, C., Ishikawa, Y., Yao, Q., Nakano, M., Arai, F., Orkin, S. H., Reversade, B., Buonamici, S., Pinello, L., Akashi, K. & 2 others, Bauer, D. E. & Maeda, T., Mar 12 2018, In : Cancer Cell. 33, 3, p. 386-400.e5

Research output: Contribution to journalArticle

Clustered Regularly Interspaced Short Palindromic Repeats
RNA Precursors
Metabolic Networks and Pathways
Leukemia
Genome

Genomic characterization of β-glucuronidase–positive escherichia coli O157:H7 producing Stx2a

Ogura, Y., Seto, K., Morimoto, Y., Nakamura, K., Sato, M. P., Gotoh, Y., Itoh, T., Toyoda, A., Ohnishi, M. & Hayashi, T., Dec 2018, In : Emerging Infectious Diseases. 24, 12, p. 2219-2227 9 p.

Research output: Contribution to journalArticle

Escherichia coli O157
Virulence
Clone Cells
Shiga-Toxigenic Escherichia coli
Diarrhea

Guest editorial: Regulatory signaling in normal and abnormal hematopoiesis

Arai, F., Jun 1 2018, In : International journal of hematology. 107, 6, p. 624-626 3 p.

Research output: Contribution to journalEditorial

Hematopoiesis
Hematopoietic Stem Cells
Stem Cells
Stem Cell Niche
Maintenance
5 Citations (Scopus)

HMGB2 expression is associated with transition from a quiescent to an activated state of adult neural stem cells

Kimura, A., Matsuda, T., Sakai, A., Murao, N. & Nakashima, K., Jan 2018, In : Developmental Dynamics. 247, 1, p. 229-238 10 p.

Research output: Contribution to journalArticle

HMGB2 Protein
Adult Stem Cells
Neural Stem Cells
Hippocampus
High Mobility Group Proteins
11 Citations (Scopus)

Neural stem cell therapy aiming at better functional recovery after spinal cord injury

Zhu, Y., Uezono, N., Yasui, T. & Nakashima, K., Jan 2018, In : Developmental Dynamics. 247, 1, p. 75-84 10 p.

Research output: Contribution to journalReview article

Neural Stem Cells
Cell- and Tissue-Based Therapy
Spinal Cord Injuries
Stem Cell Transplantation
Stem Cell Research
16 Citations (Scopus)

New aspects of glioblastoma multiforme revealed by similarities between neural and glioblastoma stem cells

Kawamura, Y., Takouda, J., Yoshimoto, K. & Nakashima, K., Dec 15 2018, In : Cell Biology and Toxicology. 34, 6, p. 425-440 16 p.

Research output: Contribution to journalReview article

Neural Stem Cells
Glioblastoma
Stem cells
Stem Cells
Epigenomics

Nuclear factor I/A coordinates the timing of oligodendrocyte differentiation/maturation via olig1 promoter methylation

Semi, K., Sanosaka, T., Namihira, M. & Nakashima, K., Apr 1 2018, In : HAYATI Journal of Biosciences. 25, 2, p. 70-78 9 p.

Research output: Contribution to journalArticle

NFI Transcription Factors
Methylation
Oligodendroglia
methylation
Transcription Factors
7 Citations (Scopus)

Prior Treatment with Anti-High Mobility Group Box-1 Antibody Boosts Human Neural Stem Cell Transplantation-Mediated Functional Recovery After Spinal Cord Injury

Uezono, N., Zhu, Y., Fujimoto, Y., Yasui, T., Matsuda, T., Nakajo, M., Abematsu, M., Setoguchi, T., Mori, S., Takahashi, H. K., Komiya, S., Nishibori, M. & Nakashima, K., May 2018, In : STEM CELLS. 36, 5, p. 737-750 14 p.

Research output: Contribution to journalArticle

Neural Stem Cells
Stem Cell Transplantation
Spinal Cord Injuries
Induced Pluripotent Stem Cells
Neurons

Rett syndrome and stem cell research

Tsujimura, K. & Nakashima, K., Jun 27 2018, Stem Cell Genetics for Biomedical Research: Past, Present, and Future. Springer International Publishing, p. 27-41 15 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Rett Syndrome
Stem Cell Research
Stem cells
Methyl-CpG-Binding Protein 2
Technology
3 Citations (Scopus)

Small RNA repertoires and their intraspecies variation in Aggregatibacter actinomycetemcomitans

Oogai, Y., Gotoh, Y., Ogura, Y., Kawada-Matsuo, M., Hayashi, T. & Komatsuzawa, H., Apr 1 2018, In : DNA Research. 25, 2, p. 207-215 9 p.

Research output: Contribution to journalArticle

Aggregatibacter actinomycetemcomitans
RNA
Intergenic DNA
Genes
Virulence
5 Citations (Scopus)

Spred1 Safeguards Hematopoietic Homeostasis against Diet-Induced Systemic Stress

Tadokoro, Y., Hoshii, T., Yamazaki, S., Eto, K., Ema, H., Kobayashi, M., Ueno, M., Ohta, K., Arai, Y., Hara, E., Harada, K., Oshima, M., Oshima, H., Arai, F., Yoshimura, A., Nakauchi, H. & Hirao, A., May 3 2018, In : Cell stem cell. 22, 5, p. 713-725.e8

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
Homeostasis
Diet
High Fat Diet
Dysbiosis

The role of hedgehog-BMP4 signaling in the patterning of coelomic mesoderm and the onset of gonadogenesis

Yoshino, T., Jun 12 2018, Cell Biology of the Ovary: Stem Cells, Development, Cancer, and Clinical Aspects. Springer Singapore, p. 21-33 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Hedgehogs
Mesoderm
Embryonic Structures
Gonads
Hedgehog Proteins
3 Citations (Scopus)

The role of telomere binding molecules for normal and abnormal hematopoiesis

Hosokawa, K. & Arai, F., Jun 1 2018, In : International journal of hematology. 107, 6, p. 646-655 10 p.

Research output: Contribution to journalReview article

Telomere
Hematopoiesis
Hematopoietic Stem Cells
Hematopoietic System
DNA Damage
2017
15 Citations (Scopus)

Bone morphogenetic protein and retinoic acid synergistically specify female germ-cell fate in mice

Miyauchi, H., Ohta, H., Nagaoka, S., Nakaki, F., Sasaki, K., Hayashi, K., Yabuta, Y., Nakamura, T., Yamamoto, T. & Saitou, M., Nov 2 2017, In : EMBO Journal. 36, 21, p. 3100-3119 20 p.

Research output: Contribution to journalArticle

Bone Morphogenetic Proteins
Tretinoin
Germ Cells
Cells
Stem cells
2 Citations (Scopus)

Detection of bidirectional promoter-derived lncRNAs from small-scale samples using pre-amplification-free directional RNA-seq method

Hamazaki, N., Nakashima, K., Hayashi, K. & Imamura, T., Jan 1 2017, Methods in Molecular Biology. Humana Press Inc., p. 83-103 21 p. (Methods in Molecular Biology; vol. 1605).

Research output: Chapter in Book/Report/Conference proceedingChapter

Long Noncoding RNA
Untranslated RNA
Interleukin-27
RNA
Transcriptional Activation
99 Citations (Scopus)

Differential cytokine contributions of perivascular haematopoietic stem cell niches

Asada, N., Kunisaki, Y., Pierce, H., Wang, Z., Fernandez, N. F., Birbrair, A., Ma'ayan, A. & Frenette, P. S., Mar 1 2017, In : Nature Cell Biology. 19, 3, p. 214-223 10 p.

Research output: Contribution to journalArticle

Stem Cell Niche
Hematopoietic Stem Cells
Cytokines
Leptin Receptors
Neuroglia