Department of Stem Cell Biology and Medicine

Research Output

2018

The role of hedgehog-BMP4 signaling in the patterning of coelomic mesoderm and the onset of gonadogenesis

Yoshino, T., Jun 12 2018, Cell Biology of the Ovary: Stem Cells, Development, Cancer, and Clinical Aspects. Springer Singapore, p. 21-33 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

The role of telomere binding molecules for normal and abnormal hematopoiesis

Hosokawa, K. & Arai, F., Jun 1 2018, In : International journal of hematology. 107, 6, p. 646-655 10 p.

Research output: Contribution to journalReview article

3 Citations (Scopus)
2017

Bone morphogenetic protein and retinoic acid synergistically specify female germ-cell fate in mice

Miyauchi, H., Ohta, H., Nagaoka, S., Nakaki, F., Sasaki, K., Hayashi, K., Yabuta, Y., Nakamura, T., Yamamoto, T. & Saitou, M., Nov 2 2017, In : EMBO Journal. 36, 21, p. 3100-3119 20 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Detection of bidirectional promoter-derived lncRNAs from small-scale samples using pre-amplification-free directional RNA-seq method

Hamazaki, N., Nakashima, K., Hayashi, K. & Imamura, T., Jan 1 2017, Methods in Molecular Biology. Humana Press Inc., p. 83-103 21 p. (Methods in Molecular Biology; vol. 1605).

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Differential cytokine contributions of perivascular haematopoietic stem cell niches

Asada, N., Kunisaki, Y., Pierce, H., Wang, Z., Fernandez, N. F., Birbrair, A., Ma'ayan, A. & Frenette, P. S., Mar 1 2017, In : Nature Cell Biology. 19, 3, p. 214-223 10 p.

Research output: Contribution to journalArticle

109 Citations (Scopus)

DNA Methylome Analysis Identifies Transcription Factor-Based Epigenomic Signatures of Multilineage Competence in Neural Stem/Progenitor Cells

Sanosaka, T., Imamura, T., Hamazaki, N., Chai, M. C., Igarashi, K., Ideta-Otsuka, M., Miura, F., Ito, T., Fujii, N., Ikeo, K. & Nakashima, K., Sep 19 2017, In : Cell Reports. 20, 12, p. 2992-3003 12 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Emerging mechanisms underlying astrogenesis in the developing mammalian brain

Takouda, J., Katada, S. & Nakashima, K., Jan 1 2017, In : Proceedings of the Japan Academy Series B: Physical and Biological Sciences. 93, 6, p. 386-398 13 p.

Research output: Contribution to journalReview article

9 Citations (Scopus)

Erratum: Correction: PCGF6-PRC1 suppresses premature differentiation of mouse embryonic stem cells by regulating germ cell-related genes (eLife (2017) 6 PII: e27970)

Endoh, M., Endo, T. A., Shinga, J., Hayashi, K., Farcas, A., Ma, K. W., Ito, S., Sharif, J., Endoh, T., Onaga, N., Nakayama, M., Ishikura, T., Masui, O., Kessler, B. M., Suda, T., Ohara, O., Okuda, A., Klose, R. J. & Koseki, H., Apr 25 2017, In : eLife. 6

Research output: Contribution to journalComment/debate

Open Access
2 Citations (Scopus)
4 Citations (Scopus)

Extremely low genomic diversity of Rickettsia japonica distributed in Japan

Akter, A., Ooka, T., Gotoh, Y., Yamamoto, S., Fujita, H., Terasoma, F., Kida, K., Taira, M., Nakadouzono, F., Gokuden, M., Hirano, M., Miyashiro, M., Inari, K., Shimazu, Y., Tabara, K., Toyoda, A., Yoshimura, D., Itoh, T., Kitano, T., Sato, M. P. & 5 others, Katsura, K., Mondal, S. I., Ogura, Y., Ando, S. & Hayashi, T., Jan 1 2017, In : Genome Biology and Evolution. 9, 1, p. 124-133 10 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Functional dissection of hematopoietic stem cell populations with a stemness-monitoring system based on NS-GFP transgene expression

Ali, M. A. E., Fuse, K., Tadokoro, Y., Hoshii, T., Ueno, M., Kobayashi, M., Nomura, N., Vu, H. T., Peng, H., Hegazy, A. M., Masuko, M., Sone, H., Arai, F., Tajima, A. & Hirao, A., Dec 1 2017, In : Scientific reports. 7, 1, 11442.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Genome-wide Association Study of Idiopathic Osteonecrosis of the Femoral Head

Sakamoto, Y., Yamamoto, T., Sugano, N., Takahashi, D., Watanabe, T., Atsumi, T., Nakamura, J., Hasegawa, Y., Akashi, K., Narita, I., Miyamoto, T., Takeuchi, T., Ikari, K., Amano, K., Fujie, A., Kubo, T., Tada, Y., Kaneuji, A., Nakamura, H., Miyamura, T. & 70 others, Kabata, T., Yamaji, K., Okawa, T., Sudo, A., Ohzono, K., Tanaka, Y., Yasunaga, Y., Matsuda, S., Imai, Y., Nakashima, Y., Motomura, G., Ikemura, S., Yamaguchi, R., Karasuyama, K., Sonoda, K., Nishii, T., Sakai, T., Takao, M., Irie, T., Asano, T., Iwasaki, N., Atsumi, T., Tamaoki, S., Nakanishi, R., Tanabe, S., Kishida, S., Hagiwara, S., Seki, T., Tsukamoto, H., Niiro, H., Arinobu, Y., Akahoshi, M., Mitoma, H., Ayano, M., Kuroda, T., Toyama, Y., Funayama, A., Hanaoka, H., Yamaoka, K., Kawaguchi, Y., Yamanaka, H., Hosozawa, T., Momohara, S., Chino, K., Fujioka, M., Ueshima, K., Ishida, M., Saito, M., Hayashi, S., Ikegami, A., Ichiseki, T., Mizokawa, S., Ohta, Y., Kajino, Y., Sekiya, F., Higuchi, F., Hasegawa, M., Miyamoto, N., Miyazaki, S., Yamaguchi, T., Ando, W., Saito, K., Nakano, K., Kuroda, Y., Yamasaki, T., Akiyama, M., Kubo, M., Kamatani, Y., Iwamoto, Y. & Ikegawa, S., Dec 1 2017, In : Scientific reports. 7, 1, 15035.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Hypoxia Epigenetically Confers Astrocytic Differentiation Potential on Human Pluripotent Cell-Derived Neural Precursor Cells

Yasui, T., Uezono, N., Nakashima, H., Noguchi, H., Matsuda, T., Noda-Andoh, T., Okano, H. & Nakashima, K., Jun 6 2017, In : Stem Cell Reports. 8, 6, p. 1743-1756 14 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Identification of unipotent megakaryocyte progenitors in human hematopoiesis

Miyawaki, K., Iwasaki, H., Jiromaru, T., Kusumoto, H., Yurino, A., Sugio, T., Uehara, Y., Odawara, J., Daitoku, S., Kunisaki, Y., Mori, Y., Arinobu, Y., Tsuzuki, H., Kikushige, Y., Iino, T., Kato, K., Takenaka, K., Miyamoto, T., Maeda, T. & Akashi, K., Jun 22 2017, In : Blood. 129, 25, p. 3332-3343 12 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Manipulation of promoter-associated noncoding RNAs in mouse early embryos for controlling sequence-specific epigenetic status

Hamazaki, N., Nakashima, K. & Imamura, T., Jan 1 2017, Methods in Molecular Biology. Humana Press Inc., p. 271-282 12 p. (Methods in Molecular Biology; vol. 1543).

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

NEUROD1 Instructs Neuronal Conversion in Non-Reactive Astrocytes

Brulet, R., Matsuda, T., Zhang, L., Miranda, C., Giacca, M., Kaspar, B. K., Nakashima, K. & Hsieh, J., Jun 6 2017, In : Stem Cell Reports. 8, 6, p. 1506-1515 10 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Novel function of MeCP2 in the pathophysiology of Rett syndrome: Regulation of mTOR signaling mediated by MeCP2-dependent microRNA processing

Tsujimura, K. & Nakashima, K., Jan 1 2017, In : Seikagaku. 89, 1, p. 51-61 11 p.

Research output: Contribution to journalReview article

PCGF6-PRC1 suppresses premature differentiation of mouse embryonic stem cells by regulating germ cell-related genes

Endoh, M., Endo, T. A., Shinga, J., Hayashi, K., Farcas, A., Ma, K. W., Ito, S., Sharif, J., Endoh, T., Onaga, N., Nakayama, M., Ishikura, T., Masui, O., Kessler, B. M., Suda, T., Ohara, O., Okuda, A., Klose, R. & Koseki, H., Mar 17 2017, In : eLife. 6, e21064.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Population structure of escherichia coli o26: H11 with recent and repeated stx2 acquisition in multiple lineages

Ogura, Y., Gotoh, Y., Itoh, T., Sato, M. P., Seto, K., Yoshino, S., Isobe, J., Etoh, Y., Kurogi, M., Kimata, K., Maeda, E., Piérard, D., Kusumoto, M., Akiba, M., Tominaga, K., Kirino, Y., Kato, Y., Shirahige, K., Ooka, T., Ishijima, N. & 4 others, Lee, K. I., Iyoda, S., Mainil, J. G. & Hayashi, T., Nov 2017, In : Microbial Genomics. 3, 11, 000141.

Research output: Contribution to journalArticle

10 Citations (Scopus)

PRMT1 regulates astrocytic differentiation of embryonic neural stem/precursor cells

Honda, M., Nakashima, K. & Katada, S., Sep 2017, In : Journal of Neurochemistry. 142, 6, p. 901-907 7 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Reconstitution of mouse oogenesis in a dish from pluripotent stem cells

Hayashi, K., Hikabe, O., Obata, Y. & Hirao, Y., Sep 1 2017, In : Nature Protocols. 12, 9, p. 1733-1744 12 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Redefining reproduction

Hayashi, K. & Perry, A., Jan 1 2017, In : Biochemist. 39, 1, p. 34-37 4 p.

Research output: Contribution to journalComment/debate

Software updates in the illumina hiseq platform affect whole-genome bisulfite sequencing

Toh, H., Shirane, K., Miura, F., Kubo, N., Ichiyanagi, K., Hayashi, K., Saitou, M., Suyama, M., Ito, T. & Sasaki, H., Jan 5 2017, In : BMC genomics. 18, 1, 31.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Stem Cell Differentiation as a Non-Markov Stochastic Process

Stumpf, P. S., Smith, R. C. G., Lenz, M., Schuppert, A., Müller, F. J., Babtie, A., Chan, T. E., Stumpf, M. P. H., Please, C. P., Howison, S. D., Arai, F. & MacArthur, B. D., Sep 27 2017, In : Cell Systems. 5, 3, p. 268-282.e7

Research output: Contribution to journalArticle

23 Citations (Scopus)

Stem cells, in vitro gametogenesis and male fertility

Nagamatsu, G. & Hayashi, K., Dec 1 2017, In : Reproduction (Cambridge, England). 154, 6, p. F79-F91

Research output: Contribution to journalReview article

17 Citations (Scopus)

Synergistic induction of astrocytic differentiation by factors secreted from meninges in the mouse developing brain

Kawamura, Y., Katada, S., Noguchi, H., Yamamoto, H., Sanosaka, T., Iihara, K. & Nakashima, K., Nov 2017, In : FEBS Letters. 591, 22, p. 3709-3720 12 p.

Research output: Contribution to journalLetter

2 Citations (Scopus)

The telomere binding protein Pot1 maintains haematopoietic stem cell activity with age

Hosokawa, K., MacArthur, B. D., Ikushima, Y. M., Toyama, H., Masuhiro, Y., Hanazawa, S., Suda, T. & Arai, F., Dec 1 2017, In : Nature communications. 8, 1, 804.

Research output: Contribution to journalArticle

9 Citations (Scopus)
2016
7 Citations (Scopus)

Complete in vitro generation of fertile oocytes from mouse primordial germ cells

Morohaku, K., Tanimoto, R., Sasaki, K., Kawahara-Miki, R., Kono, T., Hayashi, K., Hirao, Y. & Obata, Y., Aug 9 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 32, p. 9021-9026 6 p.

Research output: Contribution to journalArticle

54 Citations (Scopus)

DNA methyltransferase 1 is indispensable for development of the hippocampal dentate gyrus

Noguchi, H., Murao, N., Kimura, A., Matsuda, T., Namihira, M. & Nakashima, K., Jun 1 2016, In : Journal of Neuroscience. 36, 22, p. 6050-6068 19 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Enhanced Reconstitution of Human Erythropoiesis and Thrombopoiesis in an Immunodeficient Mouse Model with KitWv Mutations

Yurino, A., Takenaka, K., Yamauchi, T., Nunomura, T., Uehara, Y., Jinnouchi, F., Miyawaki, K., Kikushige, Y., Kato, K., Miyamoto, T., Iwasaki, H., Kunisaki, Y. & Akashi, K., Sep 13 2016, In : Stem Cell Reports. 7, 3, p. 425-438 14 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Epigenetic regulation of neural stem cell property from embryo to adult

Murao, N., Noguchi, H. & Nakashima, K., Jan 1 2016, In : Neuroepigenetics. 5, p. 1-10 10 p.

Research output: Contribution to journalReview article

21 Citations (Scopus)

Genes essential for the morphogenesis of the Shiga toxin 2-transducing phage from Escherichia coli O157:H7

Mondal, S. I., Islam, M. R., Sawaguchi, A., Asadulghani, M., Ooka, T., Gotoh, Y., Kasahara, Y., Ogura, Y. & Hayashi, T., Dec 14 2016, In : Scientific reports. 6, 39036.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Global Landscape and Regulatory Principles of DNA Methylation Reprogramming for Germ Cell Specification by Mouse Pluripotent Stem Cells

Shirane, K., Kurimoto, K., Yabuta, Y., Yamaji, M., Satoh, J., Ito, S., Watanabe, A., Hayashi, K., Saitou, M. & Sasaki, H., Oct 10 2016, In : Developmental Cell. 39, 1, p. 87-103 17 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)
8 Citations (Scopus)

Identification of genes associated with the astrocyte-specific gene Gfap during astrocyte differentiation

Ito, K., Sanosaka, T., Igarashi, K., Ideta-Otsuka, M., Aizawa, A., Uosaki, Y., Noguchi, A., Arakawa, H., Nakashima, K. & Takizawa, T., Apr 4 2016, In : Scientific reports. 6, 23903.

Research output: Contribution to journalArticle

10 Citations (Scopus)

In Vitro Derivation and Propagation of Spermatogonial Stem Cell Activity from Mouse Pluripotent Stem Cells

Ishikura, Y., Yabuta, Y., Ohta, H., Hayashi, K., Nakamura, T., Okamoto, I., Yamamoto, T., Kurimoto, K., Shirane, K., Sasaki, H. & Saitou, M., Dec 6 2016, In : Cell Reports. 17, 10, p. 2789-2804 16 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)

MicroRNA-214 promotes dendritic development by targeting the schizophrenia-associated gene quaking (Qki)

Irie, K., Tsujimura, K., Nakashima, H. & Nakashima, K., Jun 24 2016, In : Journal of Biological Chemistry. 291, 26, p. 13891-13904 14 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

p38α Activates Purine Metabolism to Initiate Hematopoietic Stem/Progenitor Cell Cycling in Response to Stress

Karigane, D., Kobayashi, H., Morikawa, T., Ootomo, Y., Sakai, M., Nagamatsu, G., Kubota, Y., Goda, N., Matsumoto, M., Nishimura, E. K., Soga, T., Otsu, K., Suematsu, M., Okamoto, S., Suda, T. & Takubo, K., Aug 4 2016, In : Cell stem cell. 19, 2, p. 192-204 13 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

PRDM14 Drives OCT3/4 Recruitment via Active Demethylation in the Transition from Primed to Naive Pluripotency

Okashita, N., Suwa, Y., Nishimura, O., Sakashita, N., Kadota, M., Nagamatsu, G., Kawaguchi, M., Kashida, H., Nakajima, A., Tachibana, M. & Seki, Y., Dec 13 2016, In : Stem Cell Reports. 7, 6, p. 1072-1086 15 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Prenatal deletion of DNA methyltransferase 1 in neural stem cells impairs neurogenesis and causes anxiety-like behavior in adulthood

Noguchi, H., Kimura, A., Murao, N., Namihira, M. & Nakashima, K., Jan 1 2016, In : Neurogenesis. 3, 1, e1232679.

Research output: Contribution to journalComment/debate

4 Citations (Scopus)

Reconstitution in vitro of the entire cycle of the mouse female germ line

Hikabe, O., Hamazaki, N., Nagamatsu, G., Obata, Y., Hirao, Y., Hamada, N., Shimamoto, S., Imamura, T., Nakashima, K., Saitou, M. & Hayashi, K., Nov 10 2016, In : Nature. 539, 7628, p. 299-303 5 p.

Research output: Contribution to journalArticle

169 Citations (Scopus)

Rewinding the process of mammalian extinction

Saragusty, J., Diecke, S., Drukker, M., Durrant, B., Friedrich Ben-Nun, I., Galli, C., Göritz, F., Hayashi, K., Hermes, R., Holtze, S., Johnson, S., Lazzari, G., Loi, P., Loring, J. F., Okita, K., Renfree, M. B., Seet, S., Voracek, T., Stejskal, J., Ryder, O. A. & 1 others, Hildebrandt, T. B., Jul 1 2016, In : Zoo biology. 35, 4, p. 280-292 13 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

Self-renewal and differentiation of hematopoietic stem cells

Arai, F., Jan 1 2016, In : [Rinsho ketsueki] The Japanese journal of clinical hematology. 57, 10, p. 1845-1851 7 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Setdb1 maintains hematopoietic stem and progenitor cells by restricting the ectopic activation of nonhematopoietic genes

Koide, S., Oshima, M., Takubo, K., Yamazaki, S., Nitta, E., Saraya, A., Aoyama, K., Kato, Y., Miyagi, S., Nakajima-Takagi, Y., Chiba, T., Matsui, H., Arai, F., Suzuki, Y., Kimura, H., Nakauchi, H., Suda, T., Shinkai, Y. & Iwama, A., Aug 4 2016, In : Blood. 128, 5, p. 638-649 12 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Targeted DNA demethylation in vivo using dCas9-peptide repeat and scFv-TET1 catalytic domain fusions

Morita, S., Noguchi, H., Horii, T., Nakabayashi, K., Kimura, M., Okamura, K., Sakai, A., Nakashima, H., Hata, K., Nakashima, K. & Hatada, I., Oct 1 2016, In : Nature Biotechnology. 34, 10, p. 1060-1065 6 p.

Research output: Contribution to journalArticle

146 Citations (Scopus)
2015

Akhirin regulates the proliferation and differentiation of neural stem cells in intact and injured mouse spinal cord

Abdulhaleem M, F. A., Song, X., Kawano, R., Uezono, N., Ito, A., Ahmed, G., Hossain, M., Nakashima, K., Tanaka, H. & Ohta, K., May 1 2015, In : Developmental Neurobiology. 75, 5, p. 494-504 11 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Bidirectional communication between the innate immune and nervous systems for homeostatic neurogenesis in the adult hippocampus

Matsuda, T. & Nakashima, K., Jan 1 2015, In : Neurogenesis. 2, 1, p. e1081714-1-e1081714-5 e1081714.

Research output: Contribution to journalComment/debate

Cancer stem cells and the niches

Kunisaki, Y., May 1 2015, In : Nihon rinsho. Japanese journal of clinical medicine. 73, 5, p. 739-744 6 p.

Research output: Contribution to journalReview article

1 Citation (Scopus)