Department of Stem Cell Biology and Medicine

Research Output 1992 2020

2015
24 Citations (Scopus)

Defining the genome features of Escherichia albertii, an emerging enteropathogen closely related to Escherichia coli

Ooka, T., Ogura, Y., Katsura, K., Seto, K., Kobayashi, H., Kawano, K., Tokuoka, E., Furukawa, M., Harada, S., Yoshino, S., Seto, J., Ikeda, T., Yamaguchi, K., Murase, K., Gotoh, Y., Imuta, N., Nishi, J., Gomes, T. A., Beutin, L. & Hayashi, T., Jan 1 2015, In : Genome Biology and Evolution. 7, 12, p. 3170-3179 10 p.

Research output: Contribution to journalArticle

Escherichia albertii
enteropathogens
Escherichia
genomics
genome
43 Citations (Scopus)

Differentiation of multipotent neural stem cells derived from Rett syndrome patients is biased toward the astrocytic lineage

Andoh-Noda, T., Akamatsu, W., Miyake, K., Matsumoto, T., Yamaguchi, R., Sanosaka, T., Okada, Y., Kobayashi, T., Ohyama, M., Nakashima, K., Kurosawa, H., Kubota, T. & Okano, H., May 27 2015, In : Molecular Brain. 8, 1, 31.

Research output: Contribution to journalArticle

Multipotent Stem Cells
Rett Syndrome
Neural Stem Cells
Induced Pluripotent Stem Cells
Methyl-CpG-Binding Protein 2
2 Citations (Scopus)

Distinct vascular niches determine hematopoietic stem cell fate

Kunisaki, Y., Jun 1 2015, In : [Rinshō ketsueki] The Japanese journal of clinical hematology. 56, 6, p. 606-613 8 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
Blood Vessels
Arterioles
Stem Cell Niche
Nestin
14 Citations (Scopus)

Expression of DNMT1 in neural stem/precursor cells is critical for survival of newly generated neurons in the adult hippocampus

Noguchi, H., Kimura, A., Murao, N., Matsuda, T., Namihira, M. & Nakashima, K., Jun 1 2015, In : Neuroscience Research. 95, p. 1-11 11 p.

Research output: Contribution to journalArticle

Neural Stem Cells
Methyltransferases
Hippocampus
Neurons
DNA
47 Citations (Scopus)

Gene activation-associated long noncoding RNAs function in mouse preimplantation development

Hamazaki, N., Uesaka, M., Nakashima, K., Agata, K. & Imamura, T., Jan 1 2015, In : Development (Cambridge). 142, 5, p. 910-920 11 p.

Research output: Contribution to journalArticle

Long Noncoding RNA
Transcriptional Activation
Untranslated RNA
Messenger RNA
Genes
8 Citations (Scopus)

Identification of hypothalamic arcuate nucleus-specific enhancer region of Kiss1 gene in mice

Goto, T., Tomikawa, J., Ikegami, K., Minabe, S., Abe, H., Fukanuma, T., Imamura, T., Takase, K., Sanbo, M., Tomita, K., Hirabayashi, M., Maeda, K. I., Tsukamura, H. & Uenoyama, Y., Jan 1 2015, In : Molecular Endocrinology. 29, 1, p. 121-129 9 p.

Research output: Contribution to journalArticle

Arcuate Nucleus of Hypothalamus
Kisspeptins
Green Fluorescent Proteins
Genes
Anterior Hypothalamus
16 Citations (Scopus)
Systemic Scleroderma
Endothelial Cells
Cytokines
T-Lymphocytes
Wounds and Injuries
8 Citations (Scopus)

Integrative Analysis of the Acquisition of Pluripotency in PGCs Reveals the Mutually Exclusive Roles of Blimp-1 and AKT Signaling

Nagamatsu, G., Saito, S., Takubo, K. & Suda, T., Jul 14 2015, In : Stem Cell Reports. 5, 1, p. 111-124 14 p.

Research output: Contribution to journalArticle

Airships
Germ Cells
Cells
Cell Dedifferentiation
Fibroblast Growth Factor 2
3 Citations (Scopus)

Isolation of mesenchymal stromal/stem cells from small-volume umbilical cord blood units that do not qualify for the banking system

Yoshioka, S., Miura, Y., Iwasa, M., Fujishiro, A., Yao, H., Miura, M., Fukuoka, M., Nakagawa, Y., Yokota, A., Hirai, H., Ichinohe, T., Takaori-Kondo, A. & Maekawa, T., Aug 11 2015, In : International journal of hematology. 102, 2, p. 218-229 12 p.

Research output: Contribution to journalArticle

Mesenchymal Stromal Cells
Fetal Blood
Cell Size
Cell Separation
Cell Count
14 Citations (Scopus)

Low-cost three-dimensional gait analysis system for mice with an infrared depth sensor

Nakamura, A., Funaya, H., Uezono, N., Nakashima, K., Ishida, Y., Suzuki, T., Wakana, S. & Shibata, T., Nov 1 2015, In : Neuroscience Research. 100, p. 55-62 8 p.

Research output: Contribution to journalArticle

Gait
Costs and Cost Analysis
Nerve Regeneration
Research

Meet our editorial board member

Nakashima, K., Aug 1 2015, In : Current Stem Cell Research and Therapy. 10, 5, 1 p.

Research output: Contribution to journalEditorial

40 Citations (Scopus)

MiR-199a Links MeCP2 with mTOR Signaling and Its Dysregulation Leads to Rett Syndrome Phenotypes

Tsujimura, K., Irie, K., Nakashima, H., Egashira, Y., Fukao, Y., Fujiwara, M., Itoh, M., Uesaka, M., Imamura, T., Nakahata, Y., Yamashita, Y., Abe, T., Takamori, S. & Nakashima, K., Sep 22 2015, In : Cell Reports. 12, 11, p. 1887-1901 15 p.

Research output: Contribution to journalArticle

Rett Syndrome
Sirolimus
Phenotype
MicroRNAs
Microcomputers
47 Citations (Scopus)

NAD+-SIRT1 control of H3K4 trimethylation through circadian deacetylation of MLL1

Aguilar-Arnal, L., Katada, S., Orozco-Solis, R. & Sassone-Corsi, P., Apr 7 2015, In : Nature Structural and Molecular Biology. 22, 4, p. 312-318 7 p.

Research output: Contribution to journalArticle

NAD
Leukemia
Acetylation
Histones
Methylation
209 Citations (Scopus)

Neutrophil ageing is regulated by the microbiome

Zhang, D., Chen, G., Manwani, D., Mortha, A., Xu, C., Faith, J. J., Burk, R. D., Kunisaki, Y., Jang, J. E., Scheiermann, C., Merad, M. & Frenette, P. S., Sep 24 2015, In : Nature. 525, 7570, p. 528-532 5 p.

Research output: Contribution to journalArticle

Microbiota
Neutrophils
Bone Marrow
Myeloid Differentiation Factor 88
CXCR4 Receptors
2 Citations (Scopus)

Possibilities in Germ Cell Research: An Engineering Insight

Esfandiari, F., Mashinchian, O., Ashtiani, M. K., Ghanian, M. H., Hayashi, K., Saei, A. A., Mahmoudi, M. & Baharvand, H., Dec 2015, In : Trends in biotechnology. 33, 12, p. 735-746 12 p.

Research output: Contribution to journalReview article

Engineering research
Germ Cells
Cells
Stem cells
Research
77 Citations (Scopus)

Quantitative dynamics of chromatin remodeling during germ cell specification from mouse embryonic stem cells

Kurimoto, K., Yabuta, Y., Hayashi, K., Ohta, H., Kiyonari, H., Mitani, T., Moritoki, Y., Kohri, K., Kimura, H., Yamamoto, T., Katou, Y., Shirahige, K. & Saitou, M., May 7 2015, In : Cell stem cell. 16, 5, p. 517-532 16 p.

Research output: Contribution to journalArticle

Chromatin Assembly and Disassembly
Germ Cells
Germ Layers
Chromatin
Developmental Genes
31 Citations (Scopus)

Reduced Adult Hippocampal Neurogenesis and Cognitive Impairments following Prenatal Treatment of the Antiepileptic Drug Valproic Acid

Juliandi, B., Tanemura, K., Igarashi, K., Tominaga, T., Furukawa, Y., Otsuka, M., Moriyama, N., Ikegami, D., Abematsu, M., Sanosaka, T., Tsujimura, K., Narita, M., Kanno, J. & Nakashima, K., Dec 8 2015, In : Stem Cell Reports. 5, 6, p. 996-1009 14 p.

Research output: Contribution to journalArticle

Neurogenesis
Valproic Acid
Anticonvulsants
Running
Therapeutics
8 Citations (Scopus)
Dermatomyositis
Interstitial Lung Diseases
Serum
Polymyositis
Protein S
1 Citation (Scopus)

The hematopoietic stem cell niche

Kunisaki, Y., Oct 1 2015, In : [Rinshō ketsueki] The Japanese journal of clinical hematology. 56, 10, p. 1888-1893 6 p.

Research output: Contribution to journalArticle

Stem Cell Niche
Hematopoietic Stem Cells
Homeostasis
Stem Cells
Bone Marrow
4 Citations (Scopus)

The role of growth differentiation factor 15 in the pathogenesis of primary myelofibrosis

Uchiyama, T., Kawabata, H., Miura, Y., Yoshioka, S., Iwasa, M., Yao, H., Sakamoto, S., Fujimoto, M., Haga, H., Kadowaki, N., Maekawa, T. & Takaori-Kondo, A., Oct 2015, In : Cancer Medicine. 4, 10, p. 1558-1572 15 p.

Research output: Contribution to journalArticle

Growth Differentiation Factor 15
Primary Myelofibrosis
Bone Marrow
Serum
Megakaryocytes
28 Citations (Scopus)

The Shiga toxin 2 production level in enterohemorrhagic Escherichia coli O157:H7 is correlated with the subtypes of toxin-encoding phage

Ogura, Y., Mondal, S. I., Islam, M. R., Mako, T., Arisawa, K., Katsura, K., Ooka, T., Gotoh, Y., Murase, K., Ohnishi, M. & Hayashi, T., Nov 16 2015, In : Scientific reports. 5, 16663.

Research output: Contribution to journalArticle

Shiga Toxin 2
Enterohemorrhagic Escherichia coli
Escherichia coli O157
Bacteriophages
Shiga Toxin
44 Citations (Scopus)

TLR9 signalling in microglia attenuates seizure-induced aberrant neurogenesis in the adult hippocampus

Matsuda, T., Murao, N., Katano, Y., Juliandi, B., Kohyama, J., Akira, S., Kawai, T. & Nakashima, K., Mar 9 2015, In : Nature communications. 6, 6514.

Research output: Contribution to journalArticle

Toll-Like Receptor 9
hippocampus
seizures
Neurogenesis
Microglia
2014
56 Citations (Scopus)

Bidirectional promoters are the major source of gene activation-associated non-coding RNAs in mammals

Uesaka, M., Nishimura, O., Go, Y., Nakashima, K., Agata, K. & Imamura, T., Jan 17 2014, In : BMC Genomics. 15, 1, 35.

Research output: Contribution to journalArticle

Untranslated RNA
Transcriptional Activation
Mammals
Long Noncoding RNA
Messenger RNA
13 Citations (Scopus)

Epigenetic mechanisms regulating differentiation of neural stem/precursor cells

Adefuin, A. M. D., Kimura, A., Noguchi, H., Nakashima, K. & Namihira, M., Dec 1 2014, In : Epigenomics. 6, 6, p. 637-649 13 p.

Research output: Contribution to journalReview article

Neural Stem Cells
Epigenomics
Untranslated RNA
Oligodendroglia
Brain
20 Citations (Scopus)
Untranslated RNA
Epigenomics
epigenetics
Genes
neurons

Generation of oocytes from mouse ES/iPS cells

Hayashi, K. & Saitou, M., Jan 1 2014, In : Journal of Mammalian Ova Research. 31, 3, p. 70-78 9 p.

Research output: Contribution to journalArticle

Germ Cells
Oocytes
Germ Layers
Induced Pluripotent Stem Cells
Cell Lineage
18 Citations (Scopus)

Influences of vascular niches on hematopoietic stem cell fate

Kunisaki, Y. & Frenette, P. S., Jun 2014, In : International journal of hematology. 99, 6, p. 699-705 7 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
Blood Vessels
Bone Marrow
Stem Cell Niche
Arterioles
233 Citations (Scopus)

Megakaryocytes regulate hematopoietic stem cell quiescence through CXCL4 secretion

Bruns, I., Lucas, D., Pinho, S., Ahmed, J., Lambert, M. P., Kunisaki, Y., Scheiermann, C., Schiff, L., Poncz, M., Bergman, A. & Frenette, P. S., Nov 1 2014, In : Nature medicine. 20, 11, p. 1315-1320 6 p.

Research output: Contribution to journalArticle

Megakaryocytes
Hematopoietic Stem Cells
Stem cells
Bone
Bone Marrow
79 Citations (Scopus)

Role of endothelial cell-derived angptl2 in vascular inflammation leading to endothelial dysfunction and atherosclerosis progression

Horio, E., Kadomatsu, T., Miyata, K., Arai, Y., Hosokawa, K., Doi, Y., Ninomiya, T., Horiguchi, H., Endo, M., Tabata, M., Tazume, H., Tian, Z., Takahashi, O., Terada, K., Takeya, M., Hao, H., Hirose, N., Minami, T., Suda, T., Kiyohara, Y. & 3 others, Ogawa, H., Kaikita, K. & Oike, Y., Apr 2014, In : Arteriosclerosis, thrombosis, and vascular biology. 34, 4, p. 790-800 11 p.

Research output: Contribution to journalArticle

Angiopoietins
Blood Vessels
Atherosclerosis
Endothelial Cells
Inflammation

Roles of Epigenetics in the Neural Stem Cell and Neuron

Yamamoto, N., Uesaka, M., Imamura, T. & Nakashima, K., Jun 20 2014, Epigenetics in Psychiatry. Elsevier Inc., p. 51-78 28 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Neural Stem Cells
Epigenomics
Neurons
Oligodendroglia
Neuroglia
10 Citations (Scopus)

Telomerase reverse transcriptase has an extratelomeric function in somatic cell reprogramming

Kinoshita, T., Nagamatsu, G., Saito, S., Takubo, K., Horimoto, K. & Suda, T., May 30 2014, In : Journal of Biological Chemistry. 289, 22, p. 15776-15787 12 p.

Research output: Contribution to journalArticle

Telomerase
Chromosomes
Stem cells
Induced Pluripotent Stem Cells
Chromosome Aberrations
1 Citation (Scopus)

Transplantation of neural stem cells with valproate for spinal cord injury

Abematsu, M. & Nakashima, K., Nov 1 2014, Neuroprotection and Regeneration of the Spinal Cord. Springer Japan, Vol. 9784431545026. p. 247-253 7 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Neural Stem Cells
Valproic Acid
Spinal Cord Injuries
Transplantation
Histone Deacetylase Inhibitors
8 Citations (Scopus)

VPA alleviates neurological deficits and restores gene expression in a mouse model of rett syndrome

Guo, W., Tsujimura, K., Otsuka I, M., Irie, K., Igarashi, K., Nakashima, K. & Zhao, X., Jun 26 2014, In : PloS one. 9, 6, e100215.

Research output: Contribution to journalArticle

valproic acid
Rett Syndrome
Valproic Acid
Gene expression
animal models
2013
119 Citations (Scopus)

A mesodermal factor, T, specifies mouse germ cell fate by directly activating germline determinants

Aramaki, S., Hayashi, K., Kurimoto, K., Ohta, H., Yabuta, Y., Iwanari, H., Mochizuki, Y., Hamakubo, T., Kato, Y., Shirahige, K. & Saitou, M., Dec 9 2013, In : Developmental Cell. 27, 5, p. 516-529 14 p.

Research output: Contribution to journalArticle

Germ Cells
Cells
Specifications
Germ Layers
Transcription Factors
23 Citations (Scopus)

DNase γ is the effector endonuclease for internucleosomal DNA fragmentation in necrosis

Mizuta, R., Araki, S., Furukawa, M., Furukawa, Y., Ebara, S., Shiokawa, D., Hayashi, K., Tanuma, S. I. & Kitamura, D., Dec 2 2013, In : PloS one. 8, 12, e80223.

Research output: Contribution to journalArticle

deoxyribonucleases
Deoxyribonucleases
Endonucleases
Deoxyribonuclease I
DNA fragmentation
38 Citations (Scopus)

Epigenetic regulation of neural stem cell fate during corticogenesis

MuhChyi, C., Juliandi, B., Matsuda, T. & Nakashima, K., Oct 1 2013, In : International Journal of Developmental Neuroscience. 31, 6, p. 424-433 10 p.

Research output: Contribution to journalArticle

Neural Stem Cells
Epigenomics
Cerebral Cortex
Multipotent Stem Cells
Intrinsic Factor
161 Citations (Scopus)

Induction of mouse germ-cell fate by transcription factors in vitro

Nakaki, F., Hayashi, K., Ohta, H., Kurimoto, K., Yabuta, Y. & Saitou, M., Aug 8 2013, In : Nature. 501, 7466, p. 222-226 5 p.

Research output: Contribution to journalArticle

Germ Cells
Transcription Factors
Germ Layers
Spermatogenesis
Embryonic Stem Cells
10 Citations (Scopus)

Induction of pluripotent stem cells from primordial germ cells by single reprogramming factors

Nagamatsu, G., Kosaka, T., Saito, S., Honda, H., Takubo, K., Kinoshita, T., Akiyama, H., Sudo, T., Horimoto, K., Oya, M. & Suda, T., Mar 1 2013, In : STEM CELLS. 31, 3, p. 479-487 9 p.

Research output: Contribution to journalArticle

Pluripotent Stem Cells
Germ Cells
Gene Expression
Cellular Reprogramming
Transcriptome
47 Citations (Scopus)

Mechanisms of astrocytogenesis in the mammalian brain

Namihira, M. & Nakashima, K., Dec 1 2013, In : Current Opinion in Neurobiology. 23, 6, p. 921-927 7 p.

Research output: Contribution to journalReview article

Astrocytes
Neural Stem Cells
Brain
Epigenomics
Multipotent Stem Cells
9 Citations (Scopus)

OP9 Bone Marrow Stroma Cells Differentiate into Megakaryocytes and Platelets

Matsubara, Y., Ono, Y., Suzuki, H., Arai, F., Suda, T., Murata, M. & Ikeda, Y., Mar 1 2013, In : PloS one. 8, 3, e58123.

Research output: Contribution to journalArticle

megakaryocytes
Megakaryocytes
Platelets
Bone Marrow Cells
bone marrow
5 Citations (Scopus)

Prenatal exposure to suberoylanilide hydroxamic acid perturbs corticogenesis

Yuniarti, N., Juliandi, B., MuhChyi, C., Noguchi, H., Sanosaka, T. & Nakashima, K., Sep 1 2013, In : Neuroscience Research. 77, 1-2, p. 42-49 8 p.

Research output: Contribution to journalArticle

Histone Deacetylases
Neurogenesis
Stem Cells
Neurons
Neural Stem Cells
24 Citations (Scopus)

Prostaglandin E2 regulates murine hematopoietic stem/progenitor cells directly via EP4 receptor and indirectly through mesenchymal progenitor cells

Ikushima, Y. M., Arai, F., Hosokawa, K., Toyama, H., Takubo, K., Furuyashiki, T., Narumiya, S. & Suda, T., Jan 1 2013, In : Blood. 121, 11, p. 1995-2007 13 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
Stem cells
Mesenchymal Stromal Cells
Dinoprostone
Recovery
299 Citations (Scopus)

Regulation of glycolysis by Pdk functions as a metabolic checkpoint for cell cycle quiescence in hematopoietic stem cells

Takubo, K., Nagamatsu, G., Kobayashi, C. I., Nakamura-Ishizu, A., Kobayashi, H., Ikeda, E., Goda, N., Rahimi, Y., Johnson, R. S., Soga, T., Hirao, A., Suematsu, M. & Suda, T., Jan 3 2013, In : Cell stem cell. 12, 1, p. 49-61 13 p.

Research output: Contribution to journalArticle

Glycolysis
Hematopoietic Stem Cells
Cell Cycle Checkpoints
Stem Cells
Cell Cycle
33 Citations (Scopus)

The cytotoxic effects of certolizumab pegol and golimumab mediated by transmembrane tumor necrosis factorα

Ueda, N., Tsukamoto, H., Mitoma, H., Ayano, M., Tanaka, A., Ohta, S. I., Inoue, Y., Arinobu, Y., Niiro, H., Akashi, K. & Horiuchi, T., May 1 2013, In : Inflammatory bowel diseases. 19, 6, p. 1224-1231 8 p.

Research output: Contribution to journalArticle

Antibody-Dependent Cell Cytotoxicity
Tumor Necrosis Factor-alpha
Crohn Disease
Jurkat Cells
Tumor Necrosis Factor Receptors
2012
167 Citations (Scopus)

Connecting threads: Epigenetics and metabolism

Katada, S., Imhof, A. & Sassone-Corsi, P., Jan 20 2012, In : Cell. 148, 1-2, p. 24-28 5 p.

Research output: Contribution to journalShort survey

Metabolism
Epigenomics
Chromatin
Histones
Nutrition
95 Citations (Scopus)

Epiblast stem cell-based system reveals reprogramming synergy of germline factors

Gillich, A., Bao, S., Grabole, N., Hayashi, K., Trotter, M. W. B., Pasque, V., Magnúsdóttir, E. & Surani, M. A., Apr 6 2012, In : Cell stem cell. 10, 4, p. 425-439 15 p.

Research output: Contribution to journalArticle

Germ Layers
Germ Cells
Stem Cells
Epigenomics
Mental Competency
76 Citations (Scopus)

Epigenetic regulation of Kiss1 gene expression mediating estrogen-positive feedback action in the mouse brain

Tomikawa, J., Uenoyama, Y., Ozawa, M., Fukanuma, T., Takase, K., Goto, T., Abe, H., Ieda, N., Minabe, S., Deura, C., Inoue, N., Sanbo, M., Tomita, K., Hirabayashi, M., Tanaka, S., Imamura, T., Okamura, H., Maeda, K. I. & Tsukamura, H., May 15 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 20, p. E1294-E1301

Research output: Contribution to journalArticle

Anterior Hypothalamus
Gene Expression Regulation
Epigenomics
Estrogens
Brain
70 Citations (Scopus)

Identification of IL-7-producing cells in primary and secondary lymphoid organs using IL-7-GFP knock-in mice

Hara, T., Shitara, S., Imai, K., Miyachi, H., Kitano, S., Yao, H., Tani-ichi, S. & Ikuta, K., Aug 15 2012, In : Journal of Immunology. 189, 4, p. 1577-1584 8 p.

Research output: Contribution to journalArticle

Interleukin-7
Vascular Cell Adhesion Molecule-1
Epithelial Cells
Endothelial Cells
Stromal Cells
24 Citations (Scopus)

Induction of superficial cortical layer neurons from mouse embryonic stem cells by valproic acid

Juliandi, B., Abematsu, M., Sanosaka, T., Tsujimura, K., Smith, A. & Nakashima, K., Jan 1 2012, In : Neuroscience Research. 72, 1, p. 23-31 9 p.

Research output: Contribution to journalArticle

Valproic Acid
Neurons
Histone Deacetylase Inhibitors
Neurogenesis
Mouse Embryonic Stem Cells
363 Citations (Scopus)

Offspring from oocytes derived from in vitro primordial germ cell-like cells in mice

Hayashi, K., Ogushi, S., Kurimoto, K., Shimamoto, S., Ohta, H. & Saitou, M., Nov 16 2012, In : Science. 338, 6109, p. 971-975 5 p.

Research output: Contribution to journalArticle

Germ Cells
Oocytes
Ovary
Reproductive Medicine
Induced Pluripotent Stem Cells