Department of Stem Cell Biology and Medicine

Research Output

2011

Epigenetic setting for long-term expression of estrogen receptor α and androgen receptor in cells

Imamura, T., Mar 1 2011, In : Hormones and Behavior. 59, 3, p. 345-352 8 p.

Research output: Contribution to journalReview article

12 Citations (Scopus)

Impact of gene dosage, loss of wild-type allele, and FLT3 ligand on Flt3-ITD-induced myeloproliferation

Kharazi, S., Mead, A. J., Mansour, A., Hultquist, A., Böiers, C., Luc, S., Buza-Vidas, N., Ma, Z., Ferry, H., Atkinson, D., Reckzeh, K., Masson, K., Cammenga, J., Rönnstrand, L., Arai, F., Suda, T., Nerlov, C., Sitnicka, E. & Jacobsen, S. E. W., Sep 29 2011, In : Blood. 118, 13, p. 3613-3621 9 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Reconstitution of the mouse germ cell specification pathway in culture by pluripotent stem cells

Hayashi, K., Ohta, H., Kurimoto, K., Aramaki, S. & Saitou, M., Aug 19 2011, In : Cell. 146, 4, p. 519-532 14 p.

Research output: Contribution to journalArticle

628 Citations (Scopus)
2010

A combination of a DNA-chimera siRNA against PLK-1 and zoledronic acid suppresses the growth of malignant mesothelioma cells in vitro

Kawata, E., Ashihara, E., Nakagawa, Y., Kiuchi, T., Ogura, M., Yao, H., Sakai, K., Tanaka, R., Nagao, R., Yokota, A., Takeuchi, M., Kimura, S., Hirai, H. & Maekawa, T., Aug 1 2010, In : Cancer Letters. 294, 2, p. 245-253 9 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Activity of the multitargeted kinase inhibitor, AT9283, in imatinib-resistant BCR-ABL-positive leukemic cells

Tanaka, R., Squires, M. S., Kimura, S., Yokota, A., Nagao, R., Yamauchi, T., Takeuchi, M., Yao, H., Reule, M., Smyth, T., Lyons, J. F., Thompson, N. T., Ashihara, E., Ottmann, O. G. & Maekawa, T., Sep 23 2010, In : Blood. 116, 12, p. 2089-2095 7 p.

Research output: Contribution to journalArticle

48 Citations (Scopus)

BMP-induced REST regulates the establishment and maintenance of astrocytic identity

Kohyama, J., Sanosaka, T., Tokunaga, A., Takatsuka, E., Tsujimura, K., Okano, H. & Nakashima, K., Apr 5 2010, In : Journal of Cell Biology. 189, 1, p. 159-170 12 p.

Research output: Contribution to journalArticle

51 Citations (Scopus)

Cadherin-Based Adhesion Is a Potential Target for Niche Manipulation to Protect Hematopoietic Stem Cells in Adult Bone Marrow

Hosokawa, K., Arai, F., Yoshihara, H., Iwasaki, H., Hembree, M., Yin, T., Nakamura, Y., Gomei, Y., Takubo, K., Shiama, H., Matsuoka, S., Li, L. & Suda, T., Mar 5 2010, In : Cell stem cell. 6, 3, p. 194-198 5 p.

Research output: Contribution to journalLetter

71 Citations (Scopus)

L1 retrotransposition in neurons is modulated by MeCP2

Muotri, A. R., Marchetto, M. C. N., Coufal, N. G., Oefner, R., Yeo, G., Nakashima, K. & Gage, F. H., Nov 18 2010, In : Nature. 468, 7322, p. 443-446 4 p.

Research output: Contribution to journalArticle

392 Citations (Scopus)

Neurons derived from transplanted neural stem cells restore disrupted neuronal circuitry in a mouse model of spinal cord injury

Abematsu, M., Tsujimura, K., Yamano, M., Saito, M., Kohno, K., Kohyama, J., Namihira, M., Komiya, S. & Nakashima, K., Sep 1 2010, In : Journal of Clinical Investigation. 120, 9, p. 3255-3266 12 p.

Research output: Contribution to journalArticle

180 Citations (Scopus)

Osteoclasts are involved in the maintenance of dormant leukemic cells

Yokota, A., Kimura, S., Tanaka, R., Takeuchi, M., Yao, H., Sakai, K., Nagao, R., Kuroda, J., Kamitsuji, Y., Kawata, E., Ashihara, E. & Maekawa, T., Jun 1 2010, In : Leukemia Research. 34, 6, p. 793-799 7 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

PER2 controls lipid metabolism by direct regulation of PPARγ

Grimaldi, B., Bellet, M. M., Katada, S., Astarita, G., Hirayama, J., Amin, R. H., Granneman, J. G., Piomelli, D., Leff, T. & Sassone-Corsi, P., Nov 3 2010, In : Cell metabolism. 12, 5, p. 509-520 12 p.

Research output: Contribution to journalArticle

232 Citations (Scopus)

Signaling through BMPR-IA regulates quiescence and long-term activity of neural stem cells in the adult hippocampus

Mira, H., Andreu, Z., Suh, H., Chichung Lie, D., Jessberger, S., Consiglio, A., Emeterio, J. S., Hortigüela, R., Marqués-Torrejón, M. Á., Nakashima, K., Colak, D., Götz, M., Fariñas, I. & Gage, F. H., Jul 2010, In : Cell stem cell. 7, 1, p. 78-89 12 p.

Research output: Contribution to journalArticle

265 Citations (Scopus)

The histone methyltransferase MLL1 permits the oscillation of circadian gene expression

Katada, S. & Sassone-Corsi, P., Dec 1 2010, In : Nature Structural and Molecular Biology. 17, 12, p. 1414-1421 8 p.

Research output: Contribution to journalArticle

163 Citations (Scopus)

TIMP-3 recruits quiescent hematopoietic stem cells into active cell cycle and expands multipotent progenitor pool

Nakajima, H., Ito, M., Smookler, D. S., Shibata, F., Fukuchi, Y., Morikawa, Y., Ikeda, Y., Arai, F., Suda, T., Khokha, R. & Kitamura, T., Nov 25 2010, In : Blood. 116, 22, p. 4474-4482 9 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)
2009

Committed Neuronal Precursors Confer Astrocytic Potential on Residual Neural Precursor Cells

Namihira, M., Kohyama, J., Semi, K., Sanosaka, T., Deneen, B., Taga, T. & Nakashima, K., Feb 17 2009, In : Developmental Cell. 16, 2, p. 245-255 11 p.

Research output: Contribution to journalArticle

211 Citations (Scopus)

Epigenetic reversion of post-implantation epiblast to pluripotent embryonic stem cells

Bao, S., Tang, F., Li, X., Hayashi, K., Gillich, A., Lao, K. & Surani, M. A., Oct 29 2009, In : Nature. 461, 7268, p. 1292-1295 4 p.

Research output: Contribution to journalArticle

281 Citations (Scopus)

Neuronal differentiation of neural precursor cells is promoted by the methyl-CpG-binding protein MeCP2

Tsujimura, K., Abematsu, M., Kohyama, J., Namihira, M. & Nakashima, K., Sep 1 2009, In : Experimental Neurology. 219, 1, p. 104-111 8 p.

Research output: Contribution to journalArticle

63 Citations (Scopus)

Wnt-mediated activation of NeuroD1 and retro-elements during adult neurogenesis

Kuwabara, T., Hsieh, J., Muotri, A., Yeo, G., Warashina, M., Lie, D. C., Moore, L., Nakashima, K., Asashima, M. & Gage, F. H., Sep 1 2009, In : Nature Neuroscience. 12, 9, p. 1097-1105 9 p.

Research output: Contribution to journalArticle

371 Citations (Scopus)
2008

A sensitive multiplex assay for piRNA expression

Tang, F., Hayashi, K., Kaneda, M., Lao, K. & Surani, M. A., May 16 2008, In : Biochemical and Biophysical Research Communications. 369, 4, p. 1190-1194 5 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Identification of stem cells during prepubertal spermatogenesis via monitoring of nucleostemin promoter activity

Ohmura, M., Naka, K., Hoshii, T., Muraguchi, T., Shugo, H., Tamase, A., Uema, N., Ooshio, T., Arai, F., Takubo, K., Nagamatsu, G., Hamaguchi, I., Takagi, M., Ishihara, M., Sakurada, K., Miyaji, H., Suda, T. & Hirao, A., Dec 1 2008, In : STEM CELLS. 26, 12, p. 3237-3246 10 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Nuclear receptor TLX regulates cell cycle progression in neural stem cells of the developing brain

Li, W., Sun, G., Yang, S., Qu, Q., Nakashima, K. & Shi, Y., Jan 1 2008, In : Molecular Endocrinology. 22, 1, p. 56-64 9 p.

Research output: Contribution to journalArticle

85 Citations (Scopus)

Response regulator YycF essential for bacterial growth: X-ray crystal structure of the DNA-binding domain and its PhoB-like DNA recognition motif

Okajima, T., Doi, A., Okada, A., Gotoh, Y., Tanizawa, K. & Utsumi, R., Oct 15 2008, In : FEBS Letters. 582, 23-24, p. 3434-3438 5 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Stem Cell Defects in ATM-Deficient Undifferentiated Spermatogonia through DNA Damage-Induced Cell-Cycle Arrest

Takubo, K., Ohmura, M., Azuma, M., Nagamatsu, G., Yamada, W., Arai, F., Hirao, A. & Suda, T., Feb 7 2008, In : Cell stem cell. 2, 2, p. 170-182 13 p.

Research output: Contribution to journalArticle

97 Citations (Scopus)

Wnt Signaling in the Niche

Suda, T. & Arai, F., Mar 7 2008, In : Cell. 132, 5, p. 729-730 2 p.

Research output: Contribution to journalShort survey

36 Citations (Scopus)
2007

Epigenetic modulation of seizure-induced neurogenesis and cognitive decline

Jessberger, S., Nakashima, K., Clemenson, G. D., Mejia, E., Mathews, E., Ure, K., Ogawa, S., Sinton, C. M., Gage, F. H. & Hsieh, J., May 30 2007, In : Journal of Neuroscience. 27, 22, p. 5967-5975 9 p.

Research output: Contribution to journalArticle

246 Citations (Scopus)

Foxo3a Is Essential for Maintenance of the Hematopoietic Stem Cell Pool

Miyamoto, K., Araki, K. Y., Naka, K., Arai, F., Takubo, K., Yamazaki, S., Matsuoka, S., Miyamoto, T., Ito, K., Ohmura, M., Chen, C., Hosokawa, K., Nakauchi, H., Nakayama, K., Nakayama, K. I., Harada, M., Motoyama, N., Suda, T. & Hirao, A., Jun 7 2007, In : Cell stem cell. 1, 1, p. 101-112 12 p.

Research output: Contribution to journalArticle

565 Citations (Scopus)

Function of oxidative stress in the regulation of hematopoietic stem cell-niche interaction

Hosokawa, K., Arai, F., Yoshihara, H., Nakamura, Y., Gomei, Y., Iwasaki, H., Miyamoto, K., Shima, H., Ito, K. & Suda, T., Nov 23 2007, In : Biochemical and Biophysical Research Communications. 363, 3, p. 578-583 6 p.

Research output: Contribution to journalArticle

90 Citations (Scopus)

Proximal visceral endoderm and extraembryonic ectoderm regulate the formation of primordial germ cell precursors

De Sousa Lopes, S. M. C., Hayashi, K. & Surani, M. A., Dec 1 2007, In : BMC Developmental Biology. 7, 140.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Thrombopoietin/MPL Signaling Regulates Hematopoietic Stem Cell Quiescence and Interaction with the Osteoblastic Niche

Yoshihara, H., Arai, F., Hosokawa, K., Hagiwara, T., Takubo, K., Nakamura, Y., Gomei, Y., Iwasaki, H., Matsuoka, S., Miyamoto, K., Miyazaki, H., Takahashi, T. & Suda, T., Dec 13 2007, In : Cell stem cell. 1, 6, p. 685-697 13 p.

Research output: Contribution to journalArticle

452 Citations (Scopus)
2006

Double knockout mice show BASH and PKCδ have different epistatic relationships in B cell maturation and CD40-mediated activation

Nojima, T., Hayashi, K., Goitsuka, R., Nakayama, K., Nakayama, K. & Kitamura, D., May 15 2006, In : Immunology Letters. 105, 1, p. 48-54 7 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Neuropoietin induces neuroepithelial cells to differentiate into astrocytes via activation of STAT3

Ohno, M., Kohyama, J., Namihira, M., Sanosaka, T., Takahashi, J. A., Hashimoto, N. & Nakashima, K., Oct 1 2006, In : Cytokine. 36, 1-2, p. 17-22 6 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Odorant Receptor Map in the Mouse Olfactory Bulb: In Vivo Sensitivity and Specificity of Receptor-Defined Glomeruli

Oka, Y., Katada, S., Omura, M., Suwa, M., Yoshihara, Y. & Touhara, K., Dec 7 2006, In : Neuron. 52, 5, p. 857-869 13 p.

Research output: Contribution to journalArticle

124 Citations (Scopus)
2004

BASH-deficient mice: Limited primary repertoire and antibody formation, but sufficient affinity maturation and memory B cell generation, in anti-NP response

Yamamoto, M., Nojima, T., Hayashi, K., Goitsuka, R., Furukawa, K., Azuma, T. & Kitamura, D., Aug 1 2004, In : International immunology. 16, 8, p. 1161-1171 11 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Developmental stage dependent regulation of DNA methylation and chromatin modification in a immature astrocyte specific gene promoter

Namihira, M., Nakashima, K. & Taga, T., Aug 13 2004, In : FEBS Letters. 572, 1-3, p. 184-188 5 p.

Research output: Contribution to journalArticle

86 Citations (Scopus)

Essential role for poly (ADP-ribosyl)ation in mouse preimplantation development

Imamura, T., Neildez, T. M. A., Thenevin, C. & Paldi, A., Jun 16 2004, In : BMC Molecular Biology. 5, 4.

Research output: Contribution to journalArticle

18 Citations (Scopus)

IGF-I instructs multipotent adult neural progenitor cells to become oligodendrocytes

Hsieh, J., Aimone, J. B., Kaspar, B. K., Kuwabara, T., Nakashima, K. & Gage, F. H., Jan 1 2004, In : Journal of Cell Biology. 164, 1, p. 111-122 12 p.

Research output: Contribution to journalArticle

247 Citations (Scopus)

Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche

Arai, F., Hirao, A., Ohmura, M., Sato, H., Matsuoka, S., Takubo, K., Ito, K., Koh, G. Y. & Suda, T., Jul 23 2004, In : Cell. 118, 2, p. 149-161 13 p.

Research output: Contribution to journalArticle

1374 Citations (Scopus)
2003

A role of suppressor of cytokine signaling 3 (SOCS3/CIS3/SSI3) in CD28-mediated interleukin 2 production

Matsumoto, A., Seki, Y. I., Watanabe, R., Hayashi, K., Johnston, J. A., Harada, Y., Abe, R., Yoshimura, A. & Kubo, M., Feb 17 2003, In : Journal of Experimental Medicine. 197, 4, p. 425-436 12 p.

Research output: Contribution to journalArticle

69 Citations (Scopus)

Distinct signaling requirements for Dμ selection, IgH allelic exclusion, Pre-B cell transition, and tumor suppression in B cell progenitors

Hayashi, K., Yamamoto, M., Nojima, T., Goitsuka, R. & Kitamura, D., Jun 1 2003, In : Immunity. 18, 6, p. 825-836 12 p.

Research output: Contribution to journalArticle

70 Citations (Scopus)

Enhanced gene activation by Notch and BMP signaling cross-talk

Takizawa, T., Ochiai, W., Nakashima, K. & Taga, T., Oct 1 2003, In : Nucleic acids research. 31, 19, p. 5723-5731 9 p.

Research output: Contribution to journalArticle

99 Citations (Scopus)

Interisland evolution of Trimeresurus flavoviridis venom phospholipase A2 isozymes

Chijiwa, T., Yamaguchi, Y., Ogawa, T., Deshimaru, M., Nobuhisa, I., Nakashima, K., Oda-Ueda, N., Fukumaki, Y., Hattori, S. & Ohno, M., Mar 1 2003, In : Journal of Molecular Evolution. 56, 3, p. 286-293 8 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)

Mice lacking methyl-CpG binding protein 1 have deficits in adult neurogenesis and hippocampal function

Zhao, X., Ueba, T., Christie, B. R., Barkho, B., McConnell, M. J., Nakashima, K., Lein, E. S., Eadie, B. D., Willhoite, A. R., Muotri, A. R., Summers, R. G., Chun, J., Lee, K. F. & Gage, F. H., May 27 2003, In : Proceedings of the National Academy of Sciences of the United States of America. 100, 11, p. 6777-6782 6 p.

Research output: Contribution to journalArticle

290 Citations (Scopus)
2002

Mesenchymal stem cells in perichondrium express activated leukocyte cell adhesion molecule and participate in bone marrow formation

Arai, F., Ohneda, O., Miyamoto, T., Zhang, X. Q. & Suda, T., Jun 17 2002, In : Journal of Experimental Medicine. 195, 12, p. 1549-1563 15 p.

Research output: Contribution to journalArticle

172 Citations (Scopus)

SMAD1 signaling is critical for initial commitment of germ cell lineage from mouse epiblast

Hayashi, K., Kobayashi, T., Umino, T., Goitsuka, R., Matsui, Y. & Kitamura, D., Oct 1 2002, In : Mechanisms of Development. 118, 1-2, p. 99-109 11 p.

Research output: Contribution to journalArticle

114 Citations (Scopus)
2001

A pivotal role for DNase I-sensitive regions 3b and/or 4 in the induction of somatic hypermutation of IgH genes

Terauchi, A., Hayashi, K., Kitamura, D., Kozono, Y., Motoyama, N. & Azuma, T., Jul 15 2001, In : Journal of Immunology. 167, 2, p. 811-820 10 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Bifurcation of osteoclasts and dendritic cells from common progenitors

Miyamoto, T., Ohneda, O., Arai, F., Iwamoto, K., Okada, S., Takagi, K., Anderson, D. M. & Suda, T., Oct 15 2001, In : Blood. 98, 8, p. 2544-2554 11 p.

Research output: Contribution to journalArticle

212 Citations (Scopus)
2000

Cell density-dependent regulation of hepatic development by a gp130-independent pathway

Kojima, N., Kinoshita, T., Kamiya, A., Nakamura, K., Nakashima, K., Taga, T. & Miyajima, A., Oct 14 2000, In : Biochemical and Biophysical Research Communications. 277, 1, p. 152-158 7 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)

Regional evolution of venom-gland phospholipase A2 isoenzymes of Trimeresurus flavoviridis snakes in the southwestern islands of Japan

Chijiwa, T., Deshimaru, M., Nobuhisa, I., Nakai, M., Ogawa, T., Oda, N., Nakashima, K. I., Fukumaki, Y., Shimohigashi, Y., Hattori, S. & Ohno, M., Apr 15 2000, In : Biochemical Journal. 347, 2, p. 491-499 9 p.

Research output: Contribution to journalArticle

50 Citations (Scopus)
1999

A novel mammalian T-box-containing gene, Tbr2, expressed in mouse developing brain

Kimura, N., Nakashima, K., Ueno, M., Kiyama, H. & Taga, T., Jun 2 1999, In : Developmental Brain Research. 115, 2, p. 183-193 11 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)

Astrocyte differentiation mediated by LIF in cooperation with BMP2

Nakashima, K., Yanagisawa, M., Arakawa, H. & Taga, T., Aug 20 1999, In : FEBS Letters. 457, 1, p. 43-46 4 p.

Research output: Contribution to journalArticle

109 Citations (Scopus)